Pub Date : 2017-03-01DOI: 10.4285/JKSTN.2017.31.1.52
D. Jeong, Sang-ho Lee, J. Moon, Y. Kim, Y. H. Lee, Kipyo Kim, Ho-Chul Park, S. Joo
Fatal Invasive Pulmonary Aspergillosis after Combined Induction with Rituximab and Antithymocyte Globulin for Kidney Transplantation in a Sensitized Recipient, and Early Rejection Therapy with Plasmapheresis and Low-dose Immunoglobulin Da Wun Jeong, M.D., Sang-Ho Lee, M.D., Ju-Young Moon, M.D., Yang-Gyun Kim, M.D., Yu Ho Lee, M.D., Kipyo Kim, M.D., Hochul Park, M.D. and Sun Hyung Joo, M.D. Division of Nephrology, Department of Internal Medicine, Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea
致敏受体肾移植联合利图ximab和抗胸腺细胞球蛋白诱导致死性侵袭性肺曲霉病，以及血浆分离和低剂量免疫球蛋白早期排斥治疗:Da Wun Jeong, M.D.， Sang-Ho Lee, M.D.， Ju-Young Moon, M.D.， Yang-Gyun Kim, M.D.， Yu Ho Lee, M.D.， Kipyo Kim, M.D.， Hochul Park, M.D.和Sun Hyung Joo, M.D.韩国首尔庆熙大学医学院江东医院
{"title":"Fatal Invasive Pulmonary Aspergillosis after Combined Induction with Rituximab and Antithymocyte Globulin for Kidney Transplantation in a Sensitized Recipient, and Early Rejection Therapy with Plasmapheresis and Low-dose Immunoglobulin","authors":"D. Jeong, Sang-ho Lee, J. Moon, Y. Kim, Y. H. Lee, Kipyo Kim, Ho-Chul Park, S. Joo","doi":"10.4285/JKSTN.2017.31.1.52","DOIUrl":"https://doi.org/10.4285/JKSTN.2017.31.1.52","url":null,"abstract":"Fatal Invasive Pulmonary Aspergillosis after Combined Induction with Rituximab and Antithymocyte Globulin for Kidney Transplantation in a Sensitized Recipient, and Early Rejection Therapy with Plasmapheresis and Low-dose Immunoglobulin Da Wun Jeong, M.D., Sang-Ho Lee, M.D., Ju-Young Moon, M.D., Yang-Gyun Kim, M.D., Yu Ho Lee, M.D., Kipyo Kim, M.D., Hochul Park, M.D. and Sun Hyung Joo, M.D. Division of Nephrology, Department of Internal Medicine, Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125405471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-01DOI: 10.4285/JKSTN.2017.31.1.6
W. Cho, Hyeon-Hoe Kim, U. Park, W. Park, Jinsuk Yu, I. Yoon, Sunil Kim, C. Ahn
Many transplant recipients believe that exercise or physical activity after transplantation will have adverse effects on the body and the grafted organ, and even more, some of them believe that the grafted organ will tear off from the vascular bed inside of the abdominal cavity. As a result, many recipients are isolated from social life even after successful recovery of the grafted organ function. However, rehabilitation by physical exercise and activity is essential to return to normal social life. In 1978, a trans-plantee’s sport game known as the Transplant Olympics, which later changed to the World Transplant Games, was started to improve the quality of life and develop friendships between transplant recipients globally. This event promotes improvement of recipient’s life quality while delivering an important message to the public. This is because by engaging in sports activities, transplantees can show their healthy life after transplantation to the public. This can also improve self-esteem of the family of organ donors and allow them to verify that their decision to donate was not in vain. Additionally, the public can realize the benefits of transplantation and necessity for organ donation. Finally, the early return to social life and normal family life after transplantation will also reduce the national budget for health insurance. Although sports clubs are located in all transplant centers in Korea, no continuous athletic meetings or transplant sport organization exist nationwide. This problem is exacerbated by the lack of concern that transplant physicians and surgeons show toward recipients’ physical activity and exercise. Therefore, in this study, we reviewed the significance of physical activity after transplantation and describe the world transplant games and domestic games to enable development of a recipient rehabilitation plan.
{"title":"Rehabilitation of Transplantee and Transplant Games","authors":"W. Cho, Hyeon-Hoe Kim, U. Park, W. Park, Jinsuk Yu, I. Yoon, Sunil Kim, C. Ahn","doi":"10.4285/JKSTN.2017.31.1.6","DOIUrl":"https://doi.org/10.4285/JKSTN.2017.31.1.6","url":null,"abstract":"Many transplant recipients believe that exercise or physical activity after transplantation will have adverse effects on the body and the grafted organ, and even more, some of them believe that the grafted organ will tear off from the vascular bed inside of the abdominal cavity. As a result, many recipients are isolated from social life even after successful recovery of the grafted organ function. However, rehabilitation by physical exercise and activity is essential to return to normal social life. In 1978, a trans-plantee’s sport game known as the Transplant Olympics, which later changed to the World Transplant Games, was started to improve the quality of life and develop friendships between transplant recipients globally. This event promotes improvement of recipient’s life quality while delivering an important message to the public. This is because by engaging in sports activities, transplantees can show their healthy life after transplantation to the public. This can also improve self-esteem of the family of organ donors and allow them to verify that their decision to donate was not in vain. Additionally, the public can realize the benefits of transplantation and necessity for organ donation. Finally, the early return to social life and normal family life after transplantation will also reduce the national budget for health insurance. Although sports clubs are located in all transplant centers in Korea, no continuous athletic meetings or transplant sport organization exist nationwide. This problem is exacerbated by the lack of concern that transplant physicians and surgeons show toward recipients’ physical activity and exercise. Therefore, in this study, we reviewed the significance of physical activity after transplantation and describe the world transplant games and domestic games to enable development of a recipient rehabilitation plan.","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126389102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-01DOI: 10.4285/JKSTN.2017.31.1.49
H. S. Jee, S. Cha, G. Kim
The diagnosis of brain death is essential for deceased donor organ transplantation. Currently, extracorporeal membrane oxygenation (ECMO) is used to increase the chance of survival of patients with severe cardiac and respiratory failure. Therefore, cases of ECMO-dependent potential donors are increasing. The apnea test (AT) is a mandatory component in the clinical determination of brain death. However, conventional AT is not easily applicable to ECMO-dependent potential donors because both the ventilator and ECMO play an important role in carbon dioxide elimination. Accordingly, different methods of AT from those used in routine procedures must be considered. We report here a case of conventional AT with time delay and two cases of AT within 3 minutes by adjusting sweep gas flow rate of ECMO in ECMO-dependent potential donors.
{"title":"Reduction of Apnea Test Time in an Extracorporeal Membrane Oxygenation-Dependent Potential Donor","authors":"H. S. Jee, S. Cha, G. Kim","doi":"10.4285/JKSTN.2017.31.1.49","DOIUrl":"https://doi.org/10.4285/JKSTN.2017.31.1.49","url":null,"abstract":"The diagnosis of brain death is essential for deceased donor organ transplantation. Currently, extracorporeal membrane oxygenation (ECMO) is used to increase the chance of survival of patients with severe cardiac and respiratory failure. Therefore, cases of ECMO-dependent potential donors are increasing. The apnea test (AT) is a mandatory component in the clinical determination of brain death. However, conventional AT is not easily applicable to ECMO-dependent potential donors because both the ventilator and ECMO play an important role in carbon dioxide elimination. Accordingly, different methods of AT from those used in routine procedures must be considered. We report here a case of conventional AT with time delay and two cases of AT within 3 minutes by adjusting sweep gas flow rate of ECMO in ECMO-dependent potential donors.","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"307 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123063855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-01DOI: 10.4285/JKSTN.2016.30.4.184
Jin Ho Lee, H. Kim, Dong Yeol Lee, J. Oh, Y. Sin, Joong-Kyung Kim, Jong Hyun Park, Kill Huh, Jong In Park
A Successful Case of a High Anti A/B Antibody Titer ABO Incompatible Kidney Transplantation Patient Who Received a Kidney from a Hepatitis B Carrier Jin Ho Lee, M.D., Han Sae Kim, M.D., Dong Yeol Lee, M.D., Joon Seok Oh, M.D., Yong Hun Sin, M.D., Joong Kyung Kim, M.D., Jong Hyun Park, M.D., Kill Huh, M.D. and Jong In Park, M.D. Departments of Internal Medicine, General Surgery, and Laboratory Medicine, Bong Seng Memorial Hospital, Busan, Korea
{"title":"A Successful Case of a High Anti A/B Antibody Titer ABO Incompatible Kidney Transplantation Patient Who Received a Kidney from a Hepatitis B Carrier","authors":"Jin Ho Lee, H. Kim, Dong Yeol Lee, J. Oh, Y. Sin, Joong-Kyung Kim, Jong Hyun Park, Kill Huh, Jong In Park","doi":"10.4285/JKSTN.2016.30.4.184","DOIUrl":"https://doi.org/10.4285/JKSTN.2016.30.4.184","url":null,"abstract":"A Successful Case of a High Anti A/B Antibody Titer ABO Incompatible Kidney Transplantation Patient Who Received a Kidney from a Hepatitis B Carrier Jin Ho Lee, M.D., Han Sae Kim, M.D., Dong Yeol Lee, M.D., Joon Seok Oh, M.D., Yong Hun Sin, M.D., Joong Kyung Kim, M.D., Jong Hyun Park, M.D., Kill Huh, M.D. and Jong In Park, M.D. Departments of Internal Medicine, General Surgery, and Laboratory Medicine, Bong Seng Memorial Hospital, Busan, Korea","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127608588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-01DOI: 10.4285/JKSTN.2016.30.4.190
H. Jeong, Jeong-Min Kim, I. Yu, Jae-Han Bae, O. Kwon, Kwang-Yeol Park
Tacrolimus is the most commonly used immunosuppressant after kidney transplantation. Here, we report a patient with multiple cerebral infarctions during tacrolimus treatment after kidney transplantation. A 54-year-old female was admitted due to sudden onset right leg weakness. Brain magnetic resonance imaging (MRI) showed multiple acute infarctions but normal vasculature. Evaluations of cardiac embolism were unremarkable. After 8 months, her weakness progressed and follow-up brain MRI showed additional multiple infarctions. We changed here medication from tacrolimus to mycophenolate mofetil, and her symptoms improved gradually.
{"title":"Calcineurin Inhibitor Induced Multiple Infarctions","authors":"H. Jeong, Jeong-Min Kim, I. Yu, Jae-Han Bae, O. Kwon, Kwang-Yeol Park","doi":"10.4285/JKSTN.2016.30.4.190","DOIUrl":"https://doi.org/10.4285/JKSTN.2016.30.4.190","url":null,"abstract":"Tacrolimus is the most commonly used immunosuppressant after kidney transplantation. Here, we report a patient with multiple cerebral infarctions during tacrolimus treatment after kidney transplantation. A 54-year-old female was admitted due to sudden onset right leg weakness. Brain magnetic resonance imaging (MRI) showed multiple acute infarctions but normal vasculature. Evaluations of cardiac embolism were unremarkable. After 8 months, her weakness progressed and follow-up brain MRI showed additional multiple infarctions. We changed here medication from tacrolimus to mycophenolate mofetil, and her symptoms improved gradually.","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131196172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-01DOI: 10.4285/JKSTN.2016.30.4.155
J. M. Kim
Hepatitis C virus (HCV)-related liver disease is the most common indication for liver transplantation (LT) in Western countries, whereas HCV LT is rare in Korea. We conducted a survey of HCV RNA-positive patients who underwent LT and investigated the prognostic factors for patient survival and the effects of immunosuppression. To accomplish this, we retrospectively reviewed the multicenter records of 192 HCV RNA-positive patients who underwent LT. The 1-, 3-, and 5-year overall survival rates were 78.8%, 75.3%, and 73.1%, respectively. Excluding cases of hospital mortality (n=23), 169 patients were evaluated. Most patients were genotype 1 (n=111, 65.7%) or genotype 2 (n=42, 24.9%). The proportion of living donors for LT (n=135, 79.9%) was higher than that of deceased donors (DDLT; n=34, 20.1%). The median donor and recipient ages were 32 and 56 years, respectively. Twenty-eight patients (16.6%) died during the observation period, while 75 underwent universal prophylaxis and 15 received preemptive therapy. HCV recurrence was detected in 97 patients. Recipients who were older than 60, received DDLT, used cyclosporine, or suffered acute rejection had lower rates of survival. Acute rejection was closely associated with a lack of induction therapy, cyclosporine use, and universal prophylaxis after transplantation. The careful avoidance of acute rejection in the post-transplant period through adequate use of tacrolimus is a preferable strategy that increases patient survival following liver transplantation.
{"title":"Outcomes for Patients with Hepatitis C Virus after Liver Transplantation in Korea","authors":"J. M. Kim","doi":"10.4285/JKSTN.2016.30.4.155","DOIUrl":"https://doi.org/10.4285/JKSTN.2016.30.4.155","url":null,"abstract":"Hepatitis C virus (HCV)-related liver disease is the most common indication for liver transplantation (LT) in Western countries, whereas HCV LT is rare in Korea. We conducted a survey of HCV RNA-positive patients who underwent LT and investigated the prognostic factors for patient survival and the effects of immunosuppression. To accomplish this, we retrospectively reviewed the multicenter records of 192 HCV RNA-positive patients who underwent LT. The 1-, 3-, and 5-year overall survival rates were 78.8%, 75.3%, and 73.1%, respectively. Excluding cases of hospital mortality (n=23), 169 patients were evaluated. Most patients were genotype 1 (n=111, 65.7%) or genotype 2 (n=42, 24.9%). The proportion of living donors for LT (n=135, 79.9%) was higher than that of deceased donors (DDLT; n=34, 20.1%). The median donor and recipient ages were 32 and 56 years, respectively. Twenty-eight patients (16.6%) died during the observation period, while 75 underwent universal prophylaxis and 15 received preemptive therapy. HCV recurrence was detected in 97 patients. Recipients who were older than 60, received DDLT, used cyclosporine, or suffered acute rejection had lower rates of survival. Acute rejection was closely associated with a lack of induction therapy, cyclosporine use, and universal prophylaxis after transplantation. The careful avoidance of acute rejection in the post-transplant period through adequate use of tacrolimus is a preferable strategy that increases patient survival following liver transplantation.","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127570688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-01DOI: 10.4285/JKSTN.2016.30.4.178
Jeong Sub Kim, C. Jung, H. Jun, K. Park
Hand-assisted Laparoscopic Donor Surgery for Living Donor Pancreas and Kidney Transplantation: A Single Center Experience Jeong Sub Kim, M.D., Cheol Woong Jung, M.D., Heungman Jun, M.D. and Kwan-Tae Park, M.D. Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea, Department of Surgery, National Medical University of Mongolia, Ulaanbaatar, Mongolia
手辅助腹腔镜供体手术用于活体胰腺和肾脏移植:单中心经验Jeong Sub Kim, M.D.， Cheol Woong Jung, M.D.， Heungman Jun, M.D.， Kwan-Tae Park, M.D.，高丽大学医学院，首尔，高丽大学安岩医院外科，蒙古国立医科大学，乌兰巴托，蒙古
{"title":"Hand-assisted Laparoscopic Donor Surgery for Living Donor Pancreas and Kidney Transplantation: A Single Center Experience","authors":"Jeong Sub Kim, C. Jung, H. Jun, K. Park","doi":"10.4285/JKSTN.2016.30.4.178","DOIUrl":"https://doi.org/10.4285/JKSTN.2016.30.4.178","url":null,"abstract":"Hand-assisted Laparoscopic Donor Surgery for Living Donor Pancreas and Kidney Transplantation: A Single Center Experience Jeong Sub Kim, M.D., Cheol Woong Jung, M.D., Heungman Jun, M.D. and Kwan-Tae Park, M.D. Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea, Department of Surgery, National Medical University of Mongolia, Ulaanbaatar, Mongolia","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129157335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-01DOI: 10.4285/JKSTN.2016.30.4.172
S. Bae, D. Han, G. Choi, J. Choi
Background: To prevent bile duct related complications, exact division of donor bile duct is essential, not only for the recipient, but also for the donor during living donor liver transplantation. Cholangiography has been used for bile duct division during living donor right hemihepatectomy. This study was conducted to determine if bile duct probe could be used to replace cholangiography for bile duct division during living donor right hemihepatectomy. Methods: Surgical outcomes of 234 donors with right hemihepatectomy and duct to duct biliary anastomosis in living donor liver transplantation between January 2009 and December 2014 were retrospectively analyzed. A total of 85 donors used the bile duct probe for bile duct division during the right hemihepatectomy, whereas 149 donors used cholangiography. All donors underwent preoperative magnetic resonance cholangiopancreatography (MRCP). Results: The expected number of bile duct orifices based on MRCP did not differ significantly from the observed number of bile duct orifices after bile duct division (10 donors and five donors in each group were mismatched, P=0.238). The operation time was 384.7 minutes in the probe group, which was significantly shorter than that of the cholangiography group (400.4 minutes, P=0.041). Conclusions: Bile duct probing without intraoperative cholangiography might be a feasible procedure for bile duct division during living donor hemihepatectomy.
{"title":"The Role of Bile Duct Probe for Bile Duct Division during Donor Right Hemihepatectomy","authors":"S. Bae, D. Han, G. Choi, J. Choi","doi":"10.4285/JKSTN.2016.30.4.172","DOIUrl":"https://doi.org/10.4285/JKSTN.2016.30.4.172","url":null,"abstract":"Background: To prevent bile duct related complications, exact division of donor bile duct is essential, not only for the recipient, but also for the donor during living donor liver transplantation. Cholangiography has been used for bile duct division during living donor right hemihepatectomy. This study was conducted to determine if bile duct probe could be used to replace cholangiography for bile duct division during living donor right hemihepatectomy. Methods: Surgical outcomes of 234 donors with right hemihepatectomy and duct to duct biliary anastomosis in living donor liver transplantation between January 2009 and December 2014 were retrospectively analyzed. A total of 85 donors used the bile duct probe for bile duct division during the right hemihepatectomy, whereas 149 donors used cholangiography. All donors underwent preoperative magnetic resonance cholangiopancreatography (MRCP). Results: The expected number of bile duct orifices based on MRCP did not differ significantly from the observed number of bile duct orifices after bile duct division (10 donors and five donors in each group were mismatched, P=0.238). The operation time was 384.7 minutes in the probe group, which was significantly shorter than that of the cholangiography group (400.4 minutes, P=0.041). Conclusions: Bile duct probing without intraoperative cholangiography might be a feasible procedure for bile duct division during living donor hemihepatectomy.","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127170749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-01DOI: 10.4285/JKSTN.2016.30.4.165
Juhan Lee, S. Song, Jae Geun Lee, B. Kim, K. Huh, Yu Seun Kim
{"title":"Sirolimus Combination with Tacrolimus in Kidney Transplant Recipients at High Immunological Risk: Observational Results 3 Years after Transplantation","authors":"Juhan Lee, S. Song, Jae Geun Lee, B. Kim, K. Huh, Yu Seun Kim","doi":"10.4285/JKSTN.2016.30.4.165","DOIUrl":"https://doi.org/10.4285/JKSTN.2016.30.4.165","url":null,"abstract":"","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115809619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-01DOI: 10.4285/JKSTN.2016.30.4.149
J. Park
In patients with detectable virus at the time of liver transplantation, hepatitis C virus (HCV) infection always recurs on the graft, and 30% of patients have an aggressive clinical and histologic course with increased morbidity, mortality, and graft loss. Moreover, in some transplantation patients, recurrent HCV infection leads to an aggressive course of disease known as fibrosing cholestatic hepatitis, which is characterized by hepatic decompensation and death. Liver allograft and recipient survival can be substantially improved with successful eradication of HCV. Recent advances in direct-acting antiviral agents have revolutionized the management of HCV infection, and a number of these agents have shown high sustained virological responses, shorter durations of treatment, and much improved tolerability when compared with previous pegylated interferon based therapies in liver transplant settings.
{"title":"Strategy for Hepatitis C Treatment in Liver Transplant Settings","authors":"J. Park","doi":"10.4285/JKSTN.2016.30.4.149","DOIUrl":"https://doi.org/10.4285/JKSTN.2016.30.4.149","url":null,"abstract":"In patients with detectable virus at the time of liver transplantation, hepatitis C virus (HCV) infection always recurs on the graft, and 30% of patients have an aggressive clinical and histologic course with increased morbidity, mortality, and graft loss. Moreover, in some transplantation patients, recurrent HCV infection leads to an aggressive course of disease known as fibrosing cholestatic hepatitis, which is characterized by hepatic decompensation and death. Liver allograft and recipient survival can be substantially improved with successful eradication of HCV. Recent advances in direct-acting antiviral agents have revolutionized the management of HCV infection, and a number of these agents have shown high sustained virological responses, shorter durations of treatment, and much improved tolerability when compared with previous pegylated interferon based therapies in liver transplant settings.","PeriodicalId":420886,"journal":{"name":"The Journal of The Korean Society for Transplantation","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114836977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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