Background: The purpose of this study was to analyze the effect of ethanolic extract of chayote on oxidative stress of obese white rats of wistar strain (Rattus novergius Sp.) induced by a high fatty diet. Method: This study uses a type of experimental laboratory research design post-test randomized controlled group. Researchers measured the effect of treatment (intervention) on the experimental group by comparing the experimental group with the control group. The sample was obtained by a simple random sampling method. Experimental sites and other research materials can be said to be homogeneous. This study will measure MDA levels as a biomarker of oxidative stress, IL-6 as a sign of inflammation, bodyweight as obesity, leptin levels as a biomarker of appetite and lipid profile levels. The research was conducted at the Biomedical Laboratory of FK UMI and started the acclimatization process, giving experimental animal surgery treatment at the animal house of FK UMI Results: The results of the study concluded that the effect of chayote ethanol extract can affect oxidative stress which has potential as anti-obesity and hypolipidemia and antioxidants. Conclusion: Ethanol extract and chayote fruit fraction have antiobesity
{"title":"The Effect of Ethanol Extract and Fruit Fraction of Chayote (Sechium Edule (Jacq.) Swartz) on Oxidative Stress and Leptin Leptins in Wistar Brain White Rats (Rattus Novergicus Sp.) High-Fatty Diet Induced Obesity","authors":"Siska Veronika, Jekson Martiar Siahaan","doi":"10.46880/ijbhm.v1i1.731","DOIUrl":"https://doi.org/10.46880/ijbhm.v1i1.731","url":null,"abstract":"Background: The purpose of this study was to analyze the effect of ethanolic extract of chayote on oxidative stress of obese white rats of wistar strain (Rattus novergius Sp.) induced by a high fatty diet. Method: This study uses a type of experimental laboratory research design post-test randomized controlled group. Researchers measured the effect of treatment (intervention) on the experimental group by comparing the experimental group with the control group. The sample was obtained by a simple random sampling method. Experimental sites and other research materials can be said to be homogeneous. This study will measure MDA levels as a biomarker of oxidative stress, IL-6 as a sign of inflammation, bodyweight as obesity, leptin levels as a biomarker of appetite and lipid profile levels. The research was conducted at the Biomedical Laboratory of FK UMI and started the acclimatization process, giving experimental animal surgery treatment at the animal house of FK UMI Results: The results of the study concluded that the effect of chayote ethanol extract can affect oxidative stress which has potential as anti-obesity and hypolipidemia and antioxidants. Conclusion: Ethanol extract and chayote fruit fraction have antiobesity","PeriodicalId":422367,"journal":{"name":"International Journal of Biomedical Herbal Medicine","volume":"181 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126170444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Basaria Manurung, P. Eyanoer, Tengku Muhammad Fauzi
Background: Hormonal and metabolic changes during pregnancy cause the pregnancy to be diabetogenic, in which GDM tends to become heavier during pregnancy and will facilitate the occurrence of various complications. DMG mothers approximately 1.7% can cause perinatal mortality, 4.3% give birth to children by surgery, 7.3% give birth to children whose birth weight is more than 4.5 kg and 23.5% can cause cases of dystocia. shoulder during labor. Methods: The study was conducted using a literature review method that focuses on the results of writing related to the effects of the Jackfruit Seed (Artocarpus heterophyllus Lam.) ethanol extract on female Wistar rats with gestational diabetes mellitus induced by Streptozotocin by browsing accredited journal sites such as Google Schoolar, Google, and Pubmed, in the period 2016-2021. Conclusion: Based on the research conducted, there was an effect of giving ethanol extract of jackfruit seeds (Artocarpus heterophyllus Lam.) to decrease blood sugar levels in female wistar rats with gestational diabetes mellitus induced by streptozotocin
{"title":"Effect Of Ethanol Extract Jackfruit (Artocarpus Heterophyllus Lam.) To Decrease Blood Sugar Levels In Wistar Female White Rats With Streptozotocin-Induced Gestational Mellitus Diabetes","authors":"Basaria Manurung, P. Eyanoer, Tengku Muhammad Fauzi","doi":"10.46880/ijbhm.v1i1.736","DOIUrl":"https://doi.org/10.46880/ijbhm.v1i1.736","url":null,"abstract":"Background: Hormonal and metabolic changes during pregnancy cause the pregnancy to be diabetogenic, in which GDM tends to become heavier during pregnancy and will facilitate the occurrence of various complications. DMG mothers approximately 1.7% can cause perinatal mortality, 4.3% give birth to children by surgery, 7.3% give birth to children whose birth weight is more than 4.5 kg and 23.5% can cause cases of dystocia. shoulder during labor. Methods: The study was conducted using a literature review method that focuses on the results of writing related to the effects of the Jackfruit Seed (Artocarpus heterophyllus Lam.) ethanol extract on female Wistar rats with gestational diabetes mellitus induced by Streptozotocin by browsing accredited journal sites such as Google Schoolar, Google, and Pubmed, in the period 2016-2021. Conclusion: Based on the research conducted, there was an effect of giving ethanol extract of jackfruit seeds (Artocarpus heterophyllus Lam.) to decrease blood sugar levels in female wistar rats with gestational diabetes mellitus induced by streptozotocin","PeriodicalId":422367,"journal":{"name":"International Journal of Biomedical Herbal Medicine","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114710462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Chronic hyperlipidemia is a trigger factor for serious diseases, one of which is atherosclerosis. Lipid profile disorders in the form of increased total cholesterol, LDL and decreased HDL levels are believed to be one of the major triggering factors for cardiovascular disease. One of the treatments for hyperlipidemia in addition to using conventional therapy can also be with traditional treatments such as aloe vera (Aloe Vera L). The content of glucomannan in aloe vera is believed to act as a hypolipidemic agent. Method: This paper uses a literature study or literature review of research articles. Search articles through Google Scholar and Pubmed with keywords used hypolipidemia and Aloe vera. The criteria for the articles used were published in the last 5 years, namely from 2016 to 2021. Results: Based on the literature search, there were 8 studies related to the effect of aloe vera on lipid profile levels, of which there were 7 studies on experimental animals and 1 study on humans. Aloe vera used varies from extract form, gel and powder form in capsules. Conclusion: Based on the literature study, it was found that aloe vera is an herbal plant that has a fairly effective hypolipidemic effect.
背景:慢性高脂血症是严重疾病的触发因素之一，动脉粥样硬化就是其中之一。以总胆固醇、低密度脂蛋白和高密度脂蛋白水平升高为形式的脂质谱紊乱被认为是心血管疾病的主要触发因素之一。治疗高脂血症的一种方法除了使用传统疗法外，还可以使用传统疗法，如芦荟(aloe vera L)。芦荟中葡甘露聚糖的含量被认为是一种降血脂剂。方法:采用文献研究法或文献综述法。通过b谷歌Scholar和Pubmed搜索文章，关键词为使用过的低血脂和芦荟。所用文章的标准是在最近5年内发布的，即2016年至2021年。结果:通过文献检索，与芦荟对血脂水平影响相关的研究有8项，其中实验动物研究7项，人体研究1项。使用的芦荟有萃取形式、凝胶形式和胶囊粉末形式。结论:通过文献研究，发现芦荟是一种具有较好降血脂作用的草本植物。
{"title":"Hypolipidemic Effects Of Aloe Vera (Aloe Vera L.)","authors":"R. Singh, H. Silitonga","doi":"10.46880/ijbhm.v1i1.732","DOIUrl":"https://doi.org/10.46880/ijbhm.v1i1.732","url":null,"abstract":"Background: Chronic hyperlipidemia is a trigger factor for serious diseases, one of which is atherosclerosis. Lipid profile disorders in the form of increased total cholesterol, LDL and decreased HDL levels are believed to be one of the major triggering factors for cardiovascular disease. One of the treatments for hyperlipidemia in addition to using conventional therapy can also be with traditional treatments such as aloe vera (Aloe Vera L). The content of glucomannan in aloe vera is believed to act as a hypolipidemic agent. Method: This paper uses a literature study or literature review of research articles. Search articles through Google Scholar and Pubmed with keywords used hypolipidemia and Aloe vera. The criteria for the articles used were published in the last 5 years, namely from 2016 to 2021. Results: Based on the literature search, there were 8 studies related to the effect of aloe vera on lipid profile levels, of which there were 7 studies on experimental animals and 1 study on humans. Aloe vera used varies from extract form, gel and powder form in capsules. Conclusion: Based on the literature study, it was found that aloe vera is an herbal plant that has a fairly effective hypolipidemic effect.","PeriodicalId":422367,"journal":{"name":"International Journal of Biomedical Herbal Medicine","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129580323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Vitiligo is a skin disease caused by the destruction of melanocytes with depigmented macular characteristics, multifactorial predisposing factors, and precipitating factors such as trauma, sunburn, stress, and systemic disease. Mimosa Pudica has bioactive compounds that are efficacious for healing wounds, repairing cell tissue, stopping bleeding, asthma, diabetes, jaundice, leprosy, hydrocele, hemorrhoids, fistulas, scrofula, and conjunctivitis. Method: Based on the results of several studies, the technique of collecting & analyzing the cream of Mimosa Pudica leaf extract was by evaluating the cream of the Mimosa Pudica leaves, testing the pH by dissolving the cream product which was diluted using aquadest and then measured with a pH meter. The production of the Mimosa Pudica leaf extract was done by maceration using 96% ethanol. Results: Mimosa Pudica extract succeeded in preserving salak fruit, increasing the regeneration and proliferation of liver cells, overcoming hypopigmentation skin disease, and also inhibiting melanosis in shrimp. Conclusion: Mimosa Pudica (Mimosa pudica L.) The five parts of the plant (i.e. panchang) - leaves, flowers, stems, roots, and fruit belong to the category of powerful antioxidants used as medicine in ethnomedical systems of care.
{"title":"The Effect Of Princess Shame Leaves Ethanol Extract On Vitiligo","authors":"Defi Defi, Endy Julianto","doi":"10.46880/ijbhm.v1i1.735","DOIUrl":"https://doi.org/10.46880/ijbhm.v1i1.735","url":null,"abstract":"Background: Vitiligo is a skin disease caused by the destruction of melanocytes with depigmented macular characteristics, multifactorial predisposing factors, and precipitating factors such as trauma, sunburn, stress, and systemic disease. Mimosa Pudica has bioactive compounds that are efficacious for healing wounds, repairing cell tissue, stopping bleeding, asthma, diabetes, jaundice, leprosy, hydrocele, hemorrhoids, fistulas, scrofula, and conjunctivitis. Method: Based on the results of several studies, the technique of collecting & analyzing the cream of Mimosa Pudica leaf extract was by evaluating the cream of the Mimosa Pudica leaves, testing the pH by dissolving the cream product which was diluted using aquadest and then measured with a pH meter. The production of the Mimosa Pudica leaf extract was done by maceration using 96% ethanol. Results: Mimosa Pudica extract succeeded in preserving salak fruit, increasing the regeneration and proliferation of liver cells, overcoming hypopigmentation skin disease, and also inhibiting melanosis in shrimp. Conclusion: Mimosa Pudica (Mimosa pudica L.) The five parts of the plant (i.e. panchang) - leaves, flowers, stems, roots, and fruit belong to the category of powerful antioxidants used as medicine in ethnomedical systems of care.","PeriodicalId":422367,"journal":{"name":"International Journal of Biomedical Herbal Medicine","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127274903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia as a result of impaired insulin secretion. The main cause of type 2 diabetes mellitus is a metabolic disorder characterized by insulin receptor resistance, reduced ability of pancreatic -cells to secrete insulin, and abnormal insulin secretion from cells of the pancreatic islets of Langerhans. In insulin resistance, the signaling defect in Phosphatidylinositol 3-kinase (PI3K) causes impaired glucose regulation in the body. The purpose of this study was to determine the effect of bitter melon extract (Momordica charantia L.) on lowering blood sugar, insulin resistance, and phosphatidylinositol 3kinase (PI3K) signaling. Method: Literature review studies from related journals. Results: Based on research conducted, it is known that bitter melon extract has an effect on blood sugar, insulin resistance, and PI3K signaling. Conclusion: Bitter gourd extract has potential as an herbal antidiuretic drug.
{"title":"The Effect of Pare (Momordica Charantia L.) Fruit Extract Fraction on Reducing Blood Sugar, Insulin Resistance and Phosphatidyl Inositol 3 Kinase (PI3K) Signalling in Male Rats (Rattus novergicus) Streptozotocin-induced Hyperglycemia","authors":"Gustiany Nadya Damanik, Hadyanto Lim","doi":"10.46880/ijbhm.v1i1.734","DOIUrl":"https://doi.org/10.46880/ijbhm.v1i1.734","url":null,"abstract":"Background: Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia as a result of impaired insulin secretion. The main cause of type 2 diabetes mellitus is a metabolic disorder characterized by insulin receptor resistance, reduced ability of pancreatic -cells to secrete insulin, and abnormal insulin secretion from cells of the pancreatic islets of Langerhans. In insulin resistance, the signaling defect in Phosphatidylinositol 3-kinase (PI3K) causes impaired glucose regulation in the body. The purpose of this study was to determine the effect of bitter melon extract (Momordica charantia L.) on lowering blood sugar, insulin resistance, and phosphatidylinositol 3kinase (PI3K) signaling. Method: Literature review studies from related journals. Results: Based on research conducted, it is known that bitter melon extract has an effect on blood sugar, insulin resistance, and PI3K signaling. Conclusion: Bitter gourd extract has potential as an herbal antidiuretic drug.","PeriodicalId":422367,"journal":{"name":"International Journal of Biomedical Herbal Medicine","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130459535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Prolonged motor and sensory block following epidural anesthesia has been associated with patient dissatisfaction. Administration of epidural crystalloids in patient who had received bupivacaine 0.75% and lidocaine 2% epidural anesthesia. However, bupivacaine 0.5% is commonly used in our institutional and the effectiveness of bolus of NS in non-obstetrical patients undergoing 0.5% bupivacaine epidural anesthesia has not been investigated. The objective of this study was to determine the relationship of normal saline (NS) epidural flush volume to the recovery of motor and sensory block and its hemodynamic stability (blood pressure and heart rate) in non-obstetrical patients undergoing epidural anesthesia using 0.5% bupivacaine. Methods: Following surgery, subjects with T6 dermatome level of sensory, were randomized to 2 treatment groups. Group 1 (control, n = 11) received 1-mL epidural normal saline (NS). Group 2 (experimental, n = 11) received an epidural bolus of 30-mL NS. Assesment of motor and sensory block was performed at 15-minute intervals until complete motor and sensory recovery. Hemodynamic stability (blood pressure and heart rate) between two groups were also monitor every 15-minutes and determined. Results: Times to full motor recovery were significantly faster in the epidural bolus of 30-mL groups than in the control group (69 ± 19.66 vs 95 ± 11.83; p = 0.0017).). Conclusions: A more rapid recovery of motor block in patients undergoing 0.5% bupivacaine epidural anesthesia can be achieved with the use of 30-mL NS epidural washout, with hemodynamic stability.
背景:硬膜外麻醉后长时间的运动和感觉阻滞与患者的不满意有关。布比卡因0.75%、利多卡因2%硬膜外麻醉患者硬膜外晶体的应用。然而，0.5%布比卡因在我们的机构中被广泛使用，对于接受0.5%布比卡因硬膜外麻醉的非产科患者，大剂量NS的有效性尚未被调查。本研究的目的是确定生理盐水(NS)硬膜外冲洗量与0.5%布比卡因硬膜外麻醉非产科患者运动和感觉阻滞恢复及其血流动力学稳定性(血压和心率)的关系。方法:手术后将感觉水平为T6的受试者随机分为2个治疗组。1组(对照组11例)给予硬膜外生理盐水1 ml。第二组(实验组，n = 11)给予30 ml NS硬膜外灌注。每隔15分钟评估一次运动和感觉阻滞，直到运动和感觉完全恢复。每隔15分钟监测两组间血流动力学稳定性(血压、心率)。结果:30 ml硬膜外注射组达到运动完全恢复所需时间明显快于对照组(69±19.66 vs 95±11.83;P = 0.0017)。结论:使用30ml NS硬膜外冲洗液可使0.5%布比卡因硬膜外麻醉患者的运动阻滞更快恢复，且血流动力学稳定。
{"title":"Reversal of Bupivacaine 0.5% Epidural Anesthesia Using Epidural Saline Washout","authors":"Jadeny Sinatra, Reuben Policarpio","doi":"10.46880/ijbhm.v1i1.730","DOIUrl":"https://doi.org/10.46880/ijbhm.v1i1.730","url":null,"abstract":"Background: Prolonged motor and sensory block following epidural anesthesia has been associated with patient dissatisfaction. Administration of epidural crystalloids in patient who had received bupivacaine 0.75% and lidocaine 2% epidural anesthesia. However, bupivacaine 0.5% is commonly used in our institutional and the effectiveness of bolus of NS in non-obstetrical patients undergoing 0.5% bupivacaine epidural anesthesia has not been investigated. The objective of this study was to determine the relationship of normal saline (NS) epidural flush volume to the recovery of motor and sensory block and its hemodynamic stability (blood pressure and heart rate) in non-obstetrical patients undergoing epidural anesthesia using 0.5% bupivacaine. Methods: Following surgery, subjects with T6 dermatome level of sensory, were randomized to 2 treatment groups. Group 1 (control, n = 11) received 1-mL epidural normal saline (NS). Group 2 (experimental, n = 11) received an epidural bolus of 30-mL NS. Assesment of motor and sensory block was performed at 15-minute intervals until complete motor and sensory recovery. Hemodynamic stability (blood pressure and heart rate) between two groups were also monitor every 15-minutes and determined. Results: Times to full motor recovery were significantly faster in the epidural bolus of 30-mL groups than in the control group (69 ± 19.66 vs 95 ± 11.83; p = 0.0017).). Conclusions: A more rapid recovery of motor block in patients undergoing 0.5% bupivacaine epidural anesthesia can be achieved with the use of 30-mL NS epidural washout, with hemodynamic stability.","PeriodicalId":422367,"journal":{"name":"International Journal of Biomedical Herbal Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115310298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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