Pub Date : 2019-07-02DOI: 10.31031/CJMI.2019.02.000548
A. Alimov
Numerous studies in the field of cancer biology prove that the development of any tumor goes through the stages of initiation, promotion and progression. The first genomedestabilizing event directs cells to the pathway of mutation accumulation, which ultimately leads to tumor development. Over the past decade, a large number of genome destabilizing factors were discovered. These include such as chemical mutagens, radiation, oncoviruses, insolation and the like. Animal viruses are among the least proven group of risk factors capable of initiating tumor growth. Skeptics argue that animal viruses do not penetrate the cells, and therefore do not initiate tumor growth [1]. Opponents of this statement give experimental data indicating the existence of more complex mechanisms of cancer initiation by zoonotic viruses.
{"title":"Zoonotic Viruses as a Risk Factor for Tumor Growth Initiation","authors":"A. Alimov","doi":"10.31031/CJMI.2019.02.000548","DOIUrl":"https://doi.org/10.31031/CJMI.2019.02.000548","url":null,"abstract":"Numerous studies in the field of cancer biology prove that the development of any tumor goes through the stages of initiation, promotion and progression. The first genomedestabilizing event directs cells to the pathway of mutation accumulation, which ultimately leads to tumor development. Over the past decade, a large number of genome destabilizing factors were discovered. These include such as chemical mutagens, radiation, oncoviruses, insolation and the like. Animal viruses are among the least proven group of risk factors capable of initiating tumor growth. Skeptics argue that animal viruses do not penetrate the cells, and therefore do not initiate tumor growth [1]. Opponents of this statement give experimental data indicating the existence of more complex mechanisms of cancer initiation by zoonotic viruses.","PeriodicalId":422893,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124366558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-10DOI: 10.31031/CJMI.2019.02.000545
Leonardo Brantes Bacellar Mendes
Cultivating microalgae from relatively simple chemical compounds and incident sunlight does not just require luck. It involves a great deal of scientific knowledge about the species chosen and the dynamic influences that biotic and abiotic factors exert on crop stability and productivity over extended periods of time. The consequences of the efforts employed in highly specialized labor and capital in general originate from the production of biomass obtained and its quality control. Microalgae biomass with high nutritional quality is usually destined to feed larvae used in aquaculture such as shrimp farming and to the nutraceutical market for human consumption.
{"title":"Micro-Algal Bioproducts a Growing Universe","authors":"Leonardo Brantes Bacellar Mendes","doi":"10.31031/CJMI.2019.02.000545","DOIUrl":"https://doi.org/10.31031/CJMI.2019.02.000545","url":null,"abstract":"Cultivating microalgae from relatively simple chemical compounds and incident sunlight does not just require luck. It involves a great deal of scientific knowledge about the species chosen and the dynamic influences that biotic and abiotic factors exert on crop stability and productivity over extended periods of time. The consequences of the efforts employed in highly specialized labor and capital in general originate from the production of biomass obtained and its quality control. Microalgae biomass with high nutritional quality is usually destined to feed larvae used in aquaculture such as shrimp farming and to the nutraceutical market for human consumption.","PeriodicalId":422893,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124525119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-09DOI: 10.31031/CJMI.2019.02.000544
G. Tarhan
An effective drinking and pool water disinfection is the most important public health reponsibility. The raw water obtained from natural sources is treated by using three basic steps: sedimentation, ventilation and filtration. With good treatment, the number of bacteria in water can be reduced by 99.5%. The water must be disinfected after pretreatment. Disinfection is generally carried out by chemical, physical or mechanical methods. The chemicals used in the disinfection process are chlorine and chlorine compounds, bromine and iodine compounds, ozone, phenol and phenolic compounds, alcohols, various dyes, soaps and synthetic detergents, ammonium compounds, hydrogen peroxide, various alkalis and acids. The use of heat and light are physical disinfection methods. With in these methods, chlorination is the most common, effective and cheapest disinfection method of water. At the same time, it is an effective microbiocide against all water-borne pathogens, although it can cause by-products after disinfection of drinking or pool water disinfection. In general, other disinfection methods are used as a supplement.
{"title":"Which Disinfection Method is Effective for Water Disinfection","authors":"G. Tarhan","doi":"10.31031/CJMI.2019.02.000544","DOIUrl":"https://doi.org/10.31031/CJMI.2019.02.000544","url":null,"abstract":"An effective drinking and pool water disinfection is the most important public health reponsibility. The raw water obtained from natural sources is treated by using three basic steps: sedimentation, ventilation and filtration. With good treatment, the number of bacteria in water can be reduced by 99.5%. The water must be disinfected after pretreatment. Disinfection is generally carried out by chemical, physical or mechanical methods. The chemicals used in the disinfection process are chlorine and chlorine compounds, bromine and iodine compounds, ozone, phenol and phenolic compounds, alcohols, various dyes, soaps and synthetic detergents, ammonium compounds, hydrogen peroxide, various alkalis and acids. The use of heat and light are physical disinfection methods. With in these methods, chlorination is the most common, effective and cheapest disinfection method of water. At the same time, it is an effective microbiocide against all water-borne pathogens, although it can cause by-products after disinfection of drinking or pool water disinfection. In general, other disinfection methods are used as a supplement.","PeriodicalId":422893,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126319265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-26DOI: 10.31031/cjmi.2019.02.000543
Mohammed Hmn, Siddig Hs, Mohammed Ba, Mohammed Ae, Ahmed Hh, Abdalgadir Hf, Alameen Nf, Mahmoud Mi
{"title":"Prevalence of Intestinal Parasitic Infections among Patients Attended to Alribat University hospital, Khartoum State, Sudan, 2017","authors":"Mohammed Hmn, Siddig Hs, Mohammed Ba, Mohammed Ae, Ahmed Hh, Abdalgadir Hf, Alameen Nf, Mahmoud Mi","doi":"10.31031/cjmi.2019.02.000543","DOIUrl":"https://doi.org/10.31031/cjmi.2019.02.000543","url":null,"abstract":"","PeriodicalId":422893,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116541079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-22DOI: 10.31031/CJMI.2019.02.000542
Mosab Nouraldein Mh
Cancer is a very serious health problem affects huge number of people around the globe, up to date there is no known treatment to cancer due to diversity of disease and unknown etiology of cancer. I think that cancer occurrence must be attributed to microbes which person gains after birth. To confirm that theory we should conduct many laboratory and clinical investigations involving large sample size with different age group and various risk factors and then examine the relation between microbe and cancer.
{"title":"Microbial Etiology of Cancer","authors":"Mosab Nouraldein Mh","doi":"10.31031/CJMI.2019.02.000542","DOIUrl":"https://doi.org/10.31031/CJMI.2019.02.000542","url":null,"abstract":"Cancer is a very serious health problem affects huge number of people around the globe, up to date there is no known treatment to cancer due to diversity of disease and unknown etiology of cancer. I think that cancer occurrence must be attributed to microbes which person gains after birth. To confirm that theory we should conduct many laboratory and clinical investigations involving large sample size with different age group and various risk factors and then examine the relation between microbe and cancer.","PeriodicalId":422893,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124212300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-25DOI: 10.31031/CJMI.2019.02.000541
Patrícia Rodrigues Lima, E. P. Oliveira, Ana Emília M Roberto, Maria DaniellaSilva Buonafina, M. C. L. Andrade, Vanessa Marques Barreto Pontes, João Vitaliano de CarvalhoRocha, R. Neves, Humberto Gonçalves Bertão, R. L. Neto
Onychomycosis is chronic ungual disease that affects people worldwide and whose prevalence has been increasing in recent decades. Among the etiological agents are yeasts, dermatophytes and non-dermatophytid filamentous fungi (NDFF). The symptoms and severity can vary widely according to the anatomic site, condition of the individual and geographic location. Laboratory identification of the fungal etiological agents is necessary due to the wide variety of these agents and the varied responses to the existing drugs. This study aimed to diagnose and characterize epidemiologically onychomycosis, besides of to determine the susceptibility profile against evaluable antifungals drugs. Patients of a Dermatological Public Service of reference at Recife city, Northeast of the Brazil, which were suffering from suggestive lesions were evaluated between August 2016 and July 2017. Mycological diagnosis was carried out by direct microscopic examination of clinical samples clarified with 20% potassium hydrochloride (KOH) and by culture in Sabouraud dextrose agar medium supplemented with 2% (v/v) chloramphenicol. After incubation for 15 days at 35-37 °C, the macro and microscopic aspects of the colonies were analyzed for specie identification. The yeasts were identified by proteomic analysis with MALDI-TOF MS. In vitro antifungal susceptibility testing was carried out according CLSI method. Signs and symptoms suggestive of onychomycosis were presented in 196 patients, of which were obtained 224 nail samples. In the mycological tests, 119 samples from 108 patients were diagnosed positively for onychomycosis, of them 77 (39.28%) from females, and the hand (fingernails) was the region most often affected, with 61 cases (31.12%). The etiological agents isolated most frequently were yeasts of Candida with 92 cases (77.31%), followed by non-dermatophytic fungi with 19 cases (15.97%), especially the genus Fusarium with 17 cases (14.28%), and dermatophytes with 8 cases (6.72%). Candida yeasts were the most prevalent etiological agents and the area most affected was the hand, associated with homemakers, who typically have greater contact with humidity. Onychomycosis caused by dermatophytes was least frequent, however terbinafine was the drug of choice for therapy in patients and in vitro more effective against dermatophytes. Most of the patients had been submitted to ineffective treatment. The yeasts were more susceptible to the antifungals and NDFF were the more resistant to the antifungals. The prescription of drug combinations can be a solution for treatment of onychomycosis caused by NDFF. The patients’ reports of longstanding symptoms indicate the chronic nature of the disease and the profile can change frequently, suggesting that periodic analyses are necessary. The frequent recurrences can be related to the high cost and long treatment periods, while public awareness campaigns can help to reduce infection rates..
{"title":"Epidemiology of Onychomycosis in Pernambuco, Northeastern of Brazil: Results of a Laboratory-Based Survey","authors":"Patrícia Rodrigues Lima, E. P. Oliveira, Ana Emília M Roberto, Maria DaniellaSilva Buonafina, M. C. L. Andrade, Vanessa Marques Barreto Pontes, João Vitaliano de CarvalhoRocha, R. Neves, Humberto Gonçalves Bertão, R. L. Neto","doi":"10.31031/CJMI.2019.02.000541","DOIUrl":"https://doi.org/10.31031/CJMI.2019.02.000541","url":null,"abstract":"Onychomycosis is chronic ungual disease that affects people worldwide and whose prevalence has been increasing in recent decades. Among the etiological agents are yeasts, dermatophytes and non-dermatophytid filamentous fungi (NDFF). The symptoms and severity can vary widely according to the anatomic site, condition of the individual and geographic location. Laboratory identification of the fungal etiological agents is necessary due to the wide variety of these agents and the varied responses to the existing drugs. This study aimed to diagnose and characterize epidemiologically onychomycosis, besides of to determine the susceptibility profile against evaluable antifungals drugs. Patients of a Dermatological Public Service of reference at Recife city, Northeast of the Brazil, which were suffering from suggestive lesions were evaluated between August 2016 and July 2017. Mycological diagnosis was carried out by direct microscopic examination of clinical samples clarified with 20% potassium hydrochloride (KOH) and by culture in Sabouraud dextrose agar medium supplemented with 2% (v/v) chloramphenicol. After incubation for 15 days at 35-37 °C, the macro and microscopic aspects of the colonies were analyzed for specie identification. The yeasts were identified by proteomic analysis with MALDI-TOF MS. In vitro antifungal susceptibility testing was carried out according CLSI method. Signs and symptoms suggestive of onychomycosis were presented in 196 patients, of which were obtained 224 nail samples. In the mycological tests, 119 samples from 108 patients were diagnosed positively for onychomycosis, of them 77 (39.28%) from females, and the hand (fingernails) was the region most often affected, with 61 cases (31.12%). The etiological agents isolated most frequently were yeasts of Candida with 92 cases (77.31%), followed by non-dermatophytic fungi with 19 cases (15.97%), especially the genus Fusarium with 17 cases (14.28%), and dermatophytes with 8 cases (6.72%). Candida yeasts were the most prevalent etiological agents and the area most affected was the hand, associated with homemakers, who typically have greater contact with humidity. Onychomycosis caused by dermatophytes was least frequent, however terbinafine was the drug of choice for therapy in patients and in vitro more effective against dermatophytes. Most of the patients had been submitted to ineffective treatment. The yeasts were more susceptible to the antifungals and NDFF were the more resistant to the antifungals. The prescription of drug combinations can be a solution for treatment of onychomycosis caused by NDFF. The patients’ reports of longstanding symptoms indicate the chronic nature of the disease and the profile can change frequently, suggesting that periodic analyses are necessary. The frequent recurrences can be related to the high cost and long treatment periods, while public awareness campaigns can help to reduce infection rates..","PeriodicalId":422893,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114872124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-18DOI: 10.31031/cjmi.2018.02.000539
I. Spiliopoulou
The aim was to compare clinical characteristics, antimicrobial resistance and 24-loci variable numbers of tandem repeats of mycobacterial interspersed repetitive units (MIRU-VNTR) patterns among M. complex isolates (MTBC) recovered from patients living in Greece during a two-year period (2009-10). Isolates from 117 tuberculosis patients identified as MTBC by a molecular method were phenotypically tested for their antimicrobial susceptibility. Clonality was accessed by MIRU-VNTR. Among 117 patients with confirmed microbiologic tuberculosis, 90 (76.9%) were of Greek origin, and 27 (23.1%) foreigners. Only 67 out of the 117 (57.3%) patients were officially reported to the Hellenic Center for Disease Control and Prevention. Phenotypic susceptibility testing revealed 10 isolates resistant to isoniazid (8.5%), two to rifampicin (1.7%), five to ethambutol (4.3%) and 17 to streptomycin (14.5%). In total two multidrug-resistant strains (1.7%) were detected. MIRU-VNTR classified 35 strains (29.9%) into 10 Families, whereas, 82 (70.1%) were not classified into any known Family. MTBC strains belonging to known Families were more commonly isolated from people living in cities and foreigners and showed a trend to higher resistance percentages to isoniazid and rifampicin. Most isolates from Greek rural areas do not belong to any known Family and are characterized by lower resistance rates.
{"title":"Characterization of Mycobacterium Tuberculosis Complex Strains: A Multicenter Retrospective Greek Study","authors":"I. Spiliopoulou","doi":"10.31031/cjmi.2018.02.000539","DOIUrl":"https://doi.org/10.31031/cjmi.2018.02.000539","url":null,"abstract":"The aim was to compare clinical characteristics, antimicrobial resistance and 24-loci variable numbers of tandem repeats of mycobacterial interspersed repetitive units (MIRU-VNTR) patterns among M. complex isolates (MTBC) recovered from patients living in Greece during a two-year period (2009-10). Isolates from 117 tuberculosis patients identified as MTBC by a molecular method were phenotypically tested for their antimicrobial susceptibility. Clonality was accessed by MIRU-VNTR. Among 117 patients with confirmed microbiologic tuberculosis, 90 (76.9%) were of Greek origin, and 27 (23.1%) foreigners. Only 67 out of the 117 (57.3%) patients were officially reported to the Hellenic Center for Disease Control and Prevention. Phenotypic susceptibility testing revealed 10 isolates resistant to isoniazid (8.5%), two to rifampicin (1.7%), five to ethambutol (4.3%) and 17 to streptomycin (14.5%). In total two multidrug-resistant strains (1.7%) were detected. MIRU-VNTR classified 35 strains (29.9%) into 10 Families, whereas, 82 (70.1%) were not classified into any known Family. MTBC strains belonging to known Families were more commonly isolated from people living in cities and foreigners and showed a trend to higher resistance percentages to isoniazid and rifampicin. Most isolates from Greek rural areas do not belong to any known Family and are characterized by lower resistance rates.","PeriodicalId":422893,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121513597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-11DOI: 10.31031/CJMI.2018.02.000538
J. Carmo
Despite many articles that have been already published in this Cohesive Journal of Microbiology and Infectious Disease, it is important to stress that some of them are not necessarily in agreement with the view of this editor. Especially the ones called “opinion”, in which their authors expresses what they think. But even when a scientist thinks in writing, it is good tone to show some references, because if they can’t reference their opinion, there might be some references in return showing disagreement or contradictions to their simplistic view. If you don’t believe in vaccines, for example, you should reference which vaccine does not work and why, scientifically, so that the discussion should be open to anyone who would like to debate it. Generalizations are not scientific, not safe and do not contribute to the scientific advancement of knowledge.
{"title":"Why are there Doubts about Vaccines Efficacy yet in 2018?","authors":"J. Carmo","doi":"10.31031/CJMI.2018.02.000538","DOIUrl":"https://doi.org/10.31031/CJMI.2018.02.000538","url":null,"abstract":"Despite many articles that have been already published in this Cohesive Journal of Microbiology and Infectious Disease, it is important to stress that some of them are not necessarily in agreement with the view of this editor. Especially the ones called “opinion”, in which their authors expresses what they think. But even when a scientist thinks in writing, it is good tone to show some references, because if they can’t reference their opinion, there might be some references in return showing disagreement or contradictions to their simplistic view. If you don’t believe in vaccines, for example, you should reference which vaccine does not work and why, scientifically, so that the discussion should be open to anyone who would like to debate it. Generalizations are not scientific, not safe and do not contribute to the scientific advancement of knowledge.","PeriodicalId":422893,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114770091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-24DOI: 10.31031/cjmi.2018.02.000535
M. Lozada
The consideration for select daptomycin, a cyclic lipopeptide antibiotic drug, approved for complicated skin and soft tissue infections, right-sided infective endocarditis and bacteraemia due to Staphylococcus aureus [1], but not approved for use in bone infection; to treat a complex pathology like CO, comes from differents factors like daptomycin’s bactericidal activity against Gram-positive bacteria, including Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococci (VRE), a novel mechanism of action that kills Grampositive bacteria by the disruption of multiple bacterial plasma membrane functions, without penetrating the cytoplasm [2]. Insertion of the lipophilic daptomycin tail into the bacterial cell membrane with oligomerization and channel formation causes rapid membrane depolarization and a potassium ion efflux. Arrest of DNA & RNA synthesis, toxin production, and protein synthesis follows, resulting in bacterial death without lysis of the cell wall, which gives a further advantage in diseases where inflammatory response associated counter antimicrobial use producing cell lysis [3-5], in addition, the in vitro potency of daptomycin has been demonstrated against Vancomycin resistant S. aureus (VRSA) and methicillin-resistant coagulase-negative staphylococci (MRCNS). The synergic effect for daptomycin that has been described in vitro with aminoglycosides (gentamicin), oxacillin, other betalactamics, macrolides and rifampicin, is very valuable to biofilm disease infections treatment, and this antibiofilm activity and reduction of the rifampicin resistance appearance makes a great value. Not antagonism interactions was observed with daptomycin use in combination with several antimicrobial agents, only additive, synergistic effect or indifference were reported. Another relevant aspect is the partial anti-biofilm activity of daptomycin, combined or alone.
{"title":"Comments of Clinical and Microbiological Experience with Daptomycin in Chronic Osteomyelitis Treatment","authors":"M. Lozada","doi":"10.31031/cjmi.2018.02.000535","DOIUrl":"https://doi.org/10.31031/cjmi.2018.02.000535","url":null,"abstract":"The consideration for select daptomycin, a cyclic lipopeptide antibiotic drug, approved for complicated skin and soft tissue infections, right-sided infective endocarditis and bacteraemia due to Staphylococcus aureus [1], but not approved for use in bone infection; to treat a complex pathology like CO, comes from differents factors like daptomycin’s bactericidal activity against Gram-positive bacteria, including Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococci (VRE), a novel mechanism of action that kills Grampositive bacteria by the disruption of multiple bacterial plasma membrane functions, without penetrating the cytoplasm [2]. Insertion of the lipophilic daptomycin tail into the bacterial cell membrane with oligomerization and channel formation causes rapid membrane depolarization and a potassium ion efflux. Arrest of DNA & RNA synthesis, toxin production, and protein synthesis follows, resulting in bacterial death without lysis of the cell wall, which gives a further advantage in diseases where inflammatory response associated counter antimicrobial use producing cell lysis [3-5], in addition, the in vitro potency of daptomycin has been demonstrated against Vancomycin resistant S. aureus (VRSA) and methicillin-resistant coagulase-negative staphylococci (MRCNS). The synergic effect for daptomycin that has been described in vitro with aminoglycosides (gentamicin), oxacillin, other betalactamics, macrolides and rifampicin, is very valuable to biofilm disease infections treatment, and this antibiofilm activity and reduction of the rifampicin resistance appearance makes a great value. Not antagonism interactions was observed with daptomycin use in combination with several antimicrobial agents, only additive, synergistic effect or indifference were reported. Another relevant aspect is the partial anti-biofilm activity of daptomycin, combined or alone.","PeriodicalId":422893,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126922273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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