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Culture wars and corporatism: The cultural mission in Australian non-fiction book publishing, 1958–2018 文化战争与社团主义:澳大利亚非小说出版的文化使命,1958–2018
4区 文学 0 LITERATURE, AFRICAN, AUSTRALIAN, CANADIAN Pub Date : 2020-04-28 DOI: 10.20314/als.dc695e21d5
Mark Davis
In this article I investigate four phases in Australian non-fiction publishing between the late 1950s and early 2000s, focused on works of current affairs, politics and popular history. Many such books, I argue, were published as part of a ‘cultural mission’ in Australian non-fiction book publishing, where an imperative for reform motivated many publishers to publish books they believed to be of greater than commercial importance. The paper first defines ‘cultural mission’ publishing. I then argue that such publishing has played a crucial role in Australian culture wars and struggles over national identity since the late 1950s and that these struggles have played out in four overlapping phases that reflect shifts in national debate and the commercial imperatives of book publishing. These consist of, first, a ‘renaissance’ phase from the late 1950s until roughly the late 1960s; second, an ‘insurrectionist’ phase from the late 1960s until the mid-1980s; third, a ‘reaction’ phase from the mid-1980s to the late 1990s, and fourth a ‘corporatist’ phase that gathered pace in the late 1990s.
在这篇文章中,我调查了20世纪50年代末至21世纪初澳大利亚非小说出版的四个阶段,重点是时事、政治和通俗史作品。我认为,许多这样的书是作为澳大利亚非小说类图书出版“文化使命”的一部分出版的,改革的必要性促使许多出版商出版他们认为比商业重要性更重要的书籍。本文首先定义了“文化使命”出版。然后,我认为,自20世纪50年代末以来,此类出版在澳大利亚文化战争和民族认同斗争中发挥了至关重要的作用,这些斗争分为四个重叠阶段,反映了国家辩论和图书出版商业需求的转变。首先,从20世纪50年代末到大约60年代末,这是一个“复兴”阶段;第二,从20世纪60年代末到80年代中期的“叛乱”阶段;第三,从20世纪80年代中期到90年代末的“反应”阶段,第四,在90年代末加速的“社团主义”阶段。
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引用次数: 1
Revaluing Memoir and Rebuilding Mothership in Maggie Nelson’s *The Argonauts* 玛吉·纳尔逊的《阿尔戈英雄》中的回忆录重估与母舰重建
4区 文学 0 LITERATURE, AFRICAN, AUSTRALIAN, CANADIAN Pub Date : 2020-04-28 DOI: 10.20314/als.ad45a0d006
A. Vickery
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引用次数: 0
Review of *Suburban Space, The Novel and Australian Modernity* by Brigid Rooney 《郊区空间、小说与澳大利亚现代性》书评布里吉德·鲁尼
4区 文学 0 LITERATURE, AFRICAN, AUSTRALIAN, CANADIAN Pub Date : 2020-04-28 DOI: 10.20314/ALS.AB77F7856A
Suzie Gibson
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引用次数: 0
On Not Having Sex: Sumner Locke Elliott and Queer History 论不做爱:萨姆纳·洛克·艾略特与酷儿历史
4区 文学 0 LITERATURE, AFRICAN, AUSTRALIAN, CANADIAN Pub Date : 2019-12-19 DOI: 10.20314/als.e772f55c21
E. Smith
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引用次数: 1
‘An Explosive Novel of Strange Passions’: Horwitz Publications and Australia’s Pulp Modernism “一部充满奇异激情的爆炸性小说”:霍维茨出版社与澳大利亚的低俗现代主义
4区 文学 0 LITERATURE, AFRICAN, AUSTRALIAN, CANADIAN Pub Date : 2019-12-19 DOI: 10.20314/als.899430d7fe
A. Nette
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引用次数: 1
Site Unscene: Medial Ideology and the Literary Interface 现场非现场:媒介意识形态与文学界面
4区 文学 0 LITERATURE, AFRICAN, AUSTRALIAN, CANADIAN Pub Date : 2019-12-19 DOI: 10.20314/als.1d07532095
J. Drucker
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引用次数: 1
Review of *Reading Corporeality in Patrick White's Fiction: An Abject Dictatorship of the Flesh*, by Bridget Grogan 《阅读帕特里克·怀特小说中的肉体:肉体的卑鄙独裁》,作者:布里奇特·格罗根
4区 文学 0 LITERATURE, AFRICAN, AUSTRALIAN, CANADIAN Pub Date : 2019-12-19 DOI: 10.20314/als.900d51983d
Jasmin Kelaita
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引用次数: 0
Review of *Ink in Her Veins: The Troubled Life of Aileen Palmer*, by Sylvia Martin Sylvia Martin的《她静脉里的墨水:艾琳·帕尔默的麻烦生活》评论
4区 文学 0 LITERATURE, AFRICAN, AUSTRALIAN, CANADIAN Pub Date : 2019-12-19 DOI: 10.20314/als.6290bec1ba
Georgina Arnott
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引用次数: 0
Serum very long-chain fatty acid-containing lipids predict response to immune checkpoint inhibitors in urological cancers. 血清中含有极长链脂肪酸的脂质可预测泌尿系统癌症患者对免疫检查点抑制剂的反应。
IF 5.8 4区 文学 0 LITERATURE, AFRICAN, AUSTRALIAN, CANADIAN Pub Date : 2019-12-01 Epub Date: 2019-11-07 DOI: 10.1007/s00262-019-02428-3
Andreas Mock, Stefanie Zschäbitz, Romy Kirsten, Matthias Scheffler, Barbara Wolf, Christel Herold-Mende, Rebecca Kramer, Elena Busch, Maximilian Jenzer, Dirk Jäger, Carsten Grüllich

Checkpoint inhibitors (CPI) have significantly changed the therapeutic landscape of oncology. We adopted a non-invasive metabolomic approach to understand immunotherapy response and failure in 28 urological cancer patients. In total, 134 metabolites were quantified in patient sera before the first, second, and third CPI doses. Modeling the association between metabolites and CPI response and patient characteristics revealed that one predictive metabolite class  (n = 9/10) were very long-chain fatty acid-containing lipids (VLCFA-containing lipids). The best predictive performance was achieved through a multivariate model, including age and a centroid of VLCFA-containing lipids prior to first immunotherapy (sensitivity: 0.850, specificity: 0.825, ROC: 0.935). We hypothesize that the association of VLCFA-containing lipids with CPI response is based on enhanced peroxisome signaling in T cells, which results in a switch to fatty acid catabolism. Beyond use as a novel predictive non-invasive biomarker, we envision that nutritional supplementation with VLCFA-containing lipids might serve as an immuno sensitizer.

检查点抑制剂(CPI)极大地改变了肿瘤学的治疗格局。我们采用非侵入性代谢组学方法来了解 28 名泌尿系统癌症患者的免疫疗法反应和失败情况。在第一次、第二次和第三次使用 CPI 之前,我们对患者血清中的 134 种代谢物进行了定量分析。建立代谢物与 CPI 反应和患者特征之间的关联模型后发现,一类具有预测性的代谢物(n = 9/10)是含极长链脂肪酸的脂质(VLCFA-containing lipids)。通过多变量模型,包括年龄和首次免疫治疗前含VLCFA脂质的中心点,可获得最佳预测效果(灵敏度:0.850,特异性:0.825,ROC:0.935)。我们假设,含 VLCFA 脂质与 CPI 反应的关联是基于 T 细胞中过氧物酶体信号的增强,从而导致脂肪酸分解代谢的转换。除了作为一种新型的预测性非侵入性生物标记物之外,我们还设想补充含 VLCFA 脂类的营养可能会成为一种免疫增敏剂。
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引用次数: 0
The Australian Kangaroo Hunt Novel (1830–1858) as *Bildungsroman* 澳大利亚袋鼠狩猎小说(1830-1858)成长小说*
4区 文学 0 LITERATURE, AFRICAN, AUSTRALIAN, CANADIAN Pub Date : 2019-07-05 DOI: 10.20314/ALS.E4D03B4165
K. Gelder, Rachael Weaver
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引用次数: 0
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AUSTRALIAN LITERARY STUDIES
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