In this article I investigate four phases in Australian non-fiction publishing between the late 1950s and early 2000s, focused on works of current affairs, politics and popular history. Many such books, I argue, were published as part of a ‘cultural mission’ in Australian non-fiction book publishing, where an imperative for reform motivated many publishers to publish books they believed to be of greater than commercial importance. The paper first defines ‘cultural mission’ publishing. I then argue that such publishing has played a crucial role in Australian culture wars and struggles over national identity since the late 1950s and that these struggles have played out in four overlapping phases that reflect shifts in national debate and the commercial imperatives of book publishing. These consist of, first, a ‘renaissance’ phase from the late 1950s until roughly the late 1960s; second, an ‘insurrectionist’ phase from the late 1960s until the mid-1980s; third, a ‘reaction’ phase from the mid-1980s to the late 1990s, and fourth a ‘corporatist’ phase that gathered pace in the late 1990s.
{"title":"Culture wars and corporatism: The cultural mission in Australian non-fiction book publishing, 1958–2018","authors":"Mark Davis","doi":"10.20314/als.dc695e21d5","DOIUrl":"https://doi.org/10.20314/als.dc695e21d5","url":null,"abstract":"In this article I investigate four phases in Australian non-fiction publishing between the late 1950s and early 2000s, focused on works of current affairs, politics and popular history. Many such books, I argue, were published as part of a ‘cultural mission’ in Australian non-fiction book publishing, where an imperative for reform motivated many publishers to publish books they believed to be of greater than commercial importance. The paper first defines ‘cultural mission’ publishing. I then argue that such publishing has played a crucial role in Australian culture wars and struggles over national identity since the late 1950s and that these struggles have played out in four overlapping phases that reflect shifts in national debate and the commercial imperatives of book publishing. These consist of, first, a ‘renaissance’ phase from the late 1950s until roughly the late 1960s; second, an ‘insurrectionist’ phase from the late 1960s until the mid-1980s; third, a ‘reaction’ phase from the mid-1980s to the late 1990s, and fourth a ‘corporatist’ phase that gathered pace in the late 1990s.","PeriodicalId":42299,"journal":{"name":"AUSTRALIAN LITERARY STUDIES","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48024103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Review of *Suburban Space, The Novel and Australian Modernity* by Brigid Rooney","authors":"Suzie Gibson","doi":"10.20314/ALS.AB77F7856A","DOIUrl":"https://doi.org/10.20314/ALS.AB77F7856A","url":null,"abstract":"","PeriodicalId":42299,"journal":{"name":"AUSTRALIAN LITERARY STUDIES","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68273270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On Not Having Sex: Sumner Locke Elliott and Queer History","authors":"E. Smith","doi":"10.20314/als.e772f55c21","DOIUrl":"https://doi.org/10.20314/als.e772f55c21","url":null,"abstract":"","PeriodicalId":42299,"journal":{"name":"AUSTRALIAN LITERARY STUDIES","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43361963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Review of *Reading Corporeality in Patrick White's Fiction: An Abject Dictatorship of the Flesh*, by Bridget Grogan","authors":"Jasmin Kelaita","doi":"10.20314/als.900d51983d","DOIUrl":"https://doi.org/10.20314/als.900d51983d","url":null,"abstract":"","PeriodicalId":42299,"journal":{"name":"AUSTRALIAN LITERARY STUDIES","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44049947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Review of *Ink in Her Veins: The Troubled Life of Aileen Palmer*, by Sylvia Martin","authors":"Georgina Arnott","doi":"10.20314/als.6290bec1ba","DOIUrl":"https://doi.org/10.20314/als.6290bec1ba","url":null,"abstract":"","PeriodicalId":42299,"journal":{"name":"AUSTRALIAN LITERARY STUDIES","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45661398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01Epub Date: 2019-11-07DOI: 10.1007/s00262-019-02428-3
Andreas Mock, Stefanie Zschäbitz, Romy Kirsten, Matthias Scheffler, Barbara Wolf, Christel Herold-Mende, Rebecca Kramer, Elena Busch, Maximilian Jenzer, Dirk Jäger, Carsten Grüllich
Checkpoint inhibitors (CPI) have significantly changed the therapeutic landscape of oncology. We adopted a non-invasive metabolomic approach to understand immunotherapy response and failure in 28 urological cancer patients. In total, 134 metabolites were quantified in patient sera before the first, second, and third CPI doses. Modeling the association between metabolites and CPI response and patient characteristics revealed that one predictive metabolite class (n = 9/10) were very long-chain fatty acid-containing lipids (VLCFA-containing lipids). The best predictive performance was achieved through a multivariate model, including age and a centroid of VLCFA-containing lipids prior to first immunotherapy (sensitivity: 0.850, specificity: 0.825, ROC: 0.935). We hypothesize that the association of VLCFA-containing lipids with CPI response is based on enhanced peroxisome signaling in T cells, which results in a switch to fatty acid catabolism. Beyond use as a novel predictive non-invasive biomarker, we envision that nutritional supplementation with VLCFA-containing lipids might serve as an immuno sensitizer.
{"title":"Serum very long-chain fatty acid-containing lipids predict response to immune checkpoint inhibitors in urological cancers.","authors":"Andreas Mock, Stefanie Zschäbitz, Romy Kirsten, Matthias Scheffler, Barbara Wolf, Christel Herold-Mende, Rebecca Kramer, Elena Busch, Maximilian Jenzer, Dirk Jäger, Carsten Grüllich","doi":"10.1007/s00262-019-02428-3","DOIUrl":"10.1007/s00262-019-02428-3","url":null,"abstract":"<p><p>Checkpoint inhibitors (CPI) have significantly changed the therapeutic landscape of oncology. We adopted a non-invasive metabolomic approach to understand immunotherapy response and failure in 28 urological cancer patients. In total, 134 metabolites were quantified in patient sera before the first, second, and third CPI doses. Modeling the association between metabolites and CPI response and patient characteristics revealed that one predictive metabolite class (n = 9/10) were very long-chain fatty acid-containing lipids (VLCFA-containing lipids). The best predictive performance was achieved through a multivariate model, including age and a centroid of VLCFA-containing lipids prior to first immunotherapy (sensitivity: 0.850, specificity: 0.825, ROC: 0.935). We hypothesize that the association of VLCFA-containing lipids with CPI response is based on enhanced peroxisome signaling in T cells, which results in a switch to fatty acid catabolism. Beyond use as a novel predictive non-invasive biomarker, we envision that nutritional supplementation with VLCFA-containing lipids might serve as an immuno sensitizer.</p>","PeriodicalId":42299,"journal":{"name":"AUSTRALIAN LITERARY STUDIES","volume":"14 1","pages":"2005-2014"},"PeriodicalIF":5.8,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11028211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90237178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}