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Enhanced contact endoscopy – new dia­gnostic method of cancerous and precancerous lesions of head and neck mucosa 增强接触内窥镜-头颈部粘膜癌和癌前病变的新诊断方法
Pub Date : 2022-05-20 DOI: 10.48095/ccorl202275
Peter Kántor, A. Švejdová, L. Staníková, K. Zeleník, P. Komínek
Early dia­gnosis of mucosal lesions of the head and neck is difficult. The lesions are usually small, malignant tumours sometimes seem benign and vice versa, and the patients’ symptoms are nonspecific. These problems may lead to a delay in the dia­gnosis of malignant tumours, or on the contrary, to unnecessarily quick indication for histologic verification of the tumour. Technological advances in recent years improved the pre-histological dia­gnosis with new endoscopic methods (especially Narrow Band Imaging – NBI and IMAGE1 STM), which allowed a better visualization of the mucosal vessels and their surroundings. Another method, called Enhanced Contact Endoscopy (ECE), combines magnifying optics and enhanced imaging modes (such as NBI and IMAGE1 S) and enables accurate assessment of the mucosal vessels of the examined lesion. Based on the changes in the vascular architecture, it is possible to assess the bio­logical character of the lesion with great precision. The aim of this article is to provide a complex overview of ECE. Key words endoscopy – laryngoscopy – carcinoma – intravital microscopy – Narrow Band Imaging – image enhancement
头颈部粘膜病变的早期诊断是困难的。病变通常很小,恶性肿瘤有时看起来是良性的,反之亦然,而且患者的症状是非特异性的。这些问题可能导致恶性肿瘤诊断的延迟,或者相反,对肿瘤的组织学验证的不必要的快速指示。近年来,随着技术的进步,新的内镜方法(特别是窄带成像- NBI和IMAGE1 STM)改善了组织前诊断,可以更好地显示粘膜血管及其周围环境。另一种方法称为增强接触内窥镜(Enhanced Contact Endoscopy, ECE),它结合了放大光学和增强成像模式(如NBI和IMAGE1 S),能够准确评估被检查病变的粘膜血管。根据血管结构的变化,可以非常精确地评估病变的生物学特征。本文的目的是提供欧洲经委会的复杂概述。关键词内窥镜-喉镜-癌-活体显微镜-窄带成像-图像增强
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引用次数: 0
Isolated lesion of the hypoglossal nerve as the result of an internal carotid artery aneurysm – case report 颈内动脉瘤引起的舌下神经孤立损伤一例报告
Pub Date : 2022-03-22 DOI: 10.48095/ccorl202244
Žofia Tóthová, Katarína Sláviková, M. Siváková, I. Vulev, M. Tedla
A 56-year-old male with arterial hypertension sought for medical help for a sudden unilateral swelling of the oral tongue and changed quality of speech. An ENT examination revealed a lesion of the left hypoglossal nerve. Neurological examinations including brain imaging showed negative results. The MRI of the neck only suggested, the angiography confirmed internal carotid aneurysm in the extracranial portion causing pressure on the hypoglossal nerve. The aneurysm was treated with a flow diverter, which reroutes the blood flow and thus embolises the aneurysm. The aneurysm shrunk, its mass effect disappeared and the function of the nerve fully recovered. Keywords: case report – hypoglossal nerve – a. carotis interna – sudden appeared lesion
一位56岁男性动脉高血压患者,因突然单侧舌部肿胀及言语质量改变而求医。耳鼻喉科检查发现左侧舌下神经病变。神经学检查包括脑成像显示阴性结果。颈部MRI仅提示,血管造影证实颅内外部分有颈内动脉瘤,造成舌下神经受压。动脉瘤用分流器治疗,分流器使血流改变方向,从而栓塞动脉瘤。动脉瘤缩小,肿块效应消失,神经功能完全恢复。关键词:病例报告舌下神经颈动脉内突发性病变
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引用次数: 0
Inflammatory myofibroblastic tumour in otorhinolaryngology 耳鼻喉科炎症性肌成纤维细胞瘤
Pub Date : 2022-03-22 DOI: 10.48095/ccorl202238
Lucie Zeinerová, M. Černý, J. Laco, J. Dědková, V. Chrobok
Introduction: Inflammatory myofibroblastic tumour (IMT) is a rare tumour with borderline biological behaviour composed of fibroblasts and myofibroblasts and accompanied by non-neoplastic inflammatory cells. It occurs mostly in children and young adults. The disease is most commonly seen in abdominal soft tissues (omentum, mesentery, etc.), in the lungs and also has been reported in other parts of gastrointestinal tract and other organs. In the head and neck region IMT is not so common, it may occur in larynx, trachea or nasal sinuses. The primary therapeutic approach is a complete surgical excision. Radiation, chemotherapy or biological treatment modalities are used in aggressive, non-resectable, and recurrent tumours or in case of metastases. Aims: Through a case report on a small set of patients and up-to-date information from the literature, the authors want to share knowledge about the rare diagnosis of IMT in ENT, its possible clinical manifestations, differential diagnosis and appropriate treatment. The group of patients, the case report: The paper presents patients with IMT treated at the Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Kralove in the years 2013–2020. The case of a 11-year-old boy with progressive dyspnoea caused by polypoid tracheal tumour is discussed in more detail. The tumour was removed by external surgical approach with bronchoscopy assistance. Histological examination proved an IMT. Conclusion: IMT is a rare neoplasm which must be included in the differential diagnosis of tumours of the respiratory tract, especially in children and young adults. The treatment consists of complete surgical removal and regular follow-up due to the risk of local recurrence. Keywords: inflammatory myofibroblastic tumour – dyspnoea in a child – tracheal tumour
炎性肌成纤维细胞瘤(IMT)是一种罕见的边缘性生物行为肿瘤,由成纤维细胞和肌成纤维细胞组成,并伴有非肿瘤性炎症细胞。它主要发生在儿童和年轻人身上。本病最常见于腹部软组织(网膜、肠系膜等)、肺部,也有胃肠道其他部位和其他器官的报道。在头颈部IMT并不常见,它可能发生在喉部、气管或鼻窦。主要的治疗方法是完全的手术切除。放射,化疗或生物治疗方式用于侵袭性,不可切除,复发性肿瘤或转移的情况。目的:通过对一小部分患者的病例报告和最新的文献信息,作者希望分享耳鼻喉科IMT的罕见诊断,其可能的临床表现,鉴别诊断和适当治疗的知识。患者组,病例报告:本文介绍了2013-2020年在赫拉德茨克拉洛韦大学医院耳鼻喉科和头颈外科接受IMT治疗的患者。病例11岁男孩的进展性呼吸困难引起的息肉状气管肿瘤的讨论更详细。在支气管镜辅助下,经外部手术入路切除肿瘤。组织学检查证实为IMT。结论:IMT是一种罕见的肿瘤,必须纳入呼吸道肿瘤的鉴别诊断,特别是在儿童和青少年中。由于有局部复发的危险,治疗包括完全手术切除和定期随访。关键词:炎性肌成纤维细胞瘤-儿童呼吸困难-气管肿瘤
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引用次数: 0
Innate immunity of the middle ear and its role in otitis media 中耳先天免疫及其在中耳炎中的作用
Pub Date : 2022-03-22 DOI: 10.48095/ccorl202224
Z. Hlávková, M. Suchánková, L. Varga
Otitis media is one of the most common diseases in the world and generally it also belongs to the most frequent causes of hearing loss. In some cases, it may progress to chronic otitis media despite adequate initial treatment. Due to its complex pathogenesis and growing resistance of pathogens to antibio­tic treatment, it is necessary to look for other therapeutic procedures that could be used to modulate and treat this disease. Therefore, it is essential to understand the role of innate immunity of the middle ear in defence against microorganisms. In this article, we discuss the role of innate immunity in otitis media and point to the role of innate immune cells in protecting the middle ear in the light of current knowledge. The innate immune system in the middle ear is responsible for rapid identification and subsequent elimination of pathogens. Cells of the immune system express a multitude of receptors with diverse functions to eliminate many infections before a weakly antigen-sensitized adaptive immunity develops. Keywords: immunogenetics – otitis media – middle ear immunity
中耳炎是世界上最常见的疾病之一,一般也属于听力损失的最常见原因。在某些情况下,尽管最初进行了适当的治疗,它仍可能发展为慢性中耳炎。由于其复杂的发病机制和病原体对抗生素治疗的日益耐药,有必要寻找其他治疗方法来调节和治疗这种疾病。因此,有必要了解中耳先天免疫在防御微生物方面的作用。在这篇文章中,我们讨论了先天免疫在中耳炎中的作用,并指出先天免疫细胞在保护中耳中的作用。中耳的先天免疫系统负责快速识别并随后消除病原体。免疫系统细胞表达多种具有不同功能的受体,在弱抗原敏感的适应性免疫发展之前消除许多感染。关键词:免疫遗传学中耳炎中耳免疫
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引用次数: 0
Microenvironment of squamous cell carcinoma of the head and neck as an analogy of a healing wound Czech version 微环境的鳞状细胞癌的头颈部作为愈合伤口捷克版的类比
Pub Date : 2022-03-22 DOI: 10.48095/ccorl202218
Veronika Bandúrová, K. Smetana, J. Plzák, B. Dvořánková
Numerous interactions occur among fibroblasts, keratinocytes and immune cells during wound healing. The release of cytokines supports formation of granular tissue which then fills the wound. A chronic wound appears when this complex process is disrupted. We can see this problem in patients with diabetes. Granular tissue is very similar to the stroma of solid tumors. This work is focused on parallels between a healing wound and tumor. It aims to clearly describe the regulation of both processes. New knowledge in this field can contribute to revealing new therapeutic possibilities in chronic wounds and solid tumors. Keywords: squamous cell carcinoma – Head and neck tumors – healing – tumor microenvironment
在伤口愈合过程中,成纤维细胞、角化细胞和免疫细胞之间发生了许多相互作用。细胞因子的释放支持颗粒组织的形成,然后填充伤口。当这个复杂的过程被破坏时,就会出现慢性伤口。我们可以在糖尿病患者身上看到这个问题。颗粒组织与实体瘤间质非常相似。这项工作的重点是愈合伤口和肿瘤之间的相似之处。它旨在清楚地描述这两个过程的监管。该领域的新知识有助于揭示慢性伤口和实体肿瘤的新治疗可能性。关键词:鳞状细胞癌头颈部肿瘤愈合肿瘤微环境
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引用次数: 0
The effect of surgical therapy of obstructive sleep apnoea syndrome on Positive Airway Pressure therapy – first results Czech version 手术治疗阻塞性睡眠呼吸暂停综合征对正压通气治疗的影响——捷克版
Pub Date : 2022-03-22 DOI: 10.48095/ccorl202213
J. Kalhous, Jan Kordík
The effect of surgical therapy of obstructive sleep apnoea syndrome on Positive Airway Pressure therapy – first results Czech version
手术治疗阻塞性睡眠呼吸暂停综合征对正压通气治疗的影响——捷克版
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引用次数: 0
Adaptation and validation of the Czech version of the nasal obstruction symptom evaluation scale (NOSE-cz) 捷克版鼻塞症状评价量表(NOSE-cz)的改编与验证
Pub Date : 2022-03-22 DOI: 10.48095/ccorl20229
Z. Hornáčková, L. Otruba, R. Kaňa, Jakub Fuksa, P. Schalek
Background: Nasal obstruction is one of the most common symptoms in rhinology. In 2004, Stewart published a very simple instrument of nasal obstruction symptom evaluation (NOSE), which has already been adapted and validated in a number of languages. The aim of this study was to validate the Czech version of the questionnaire (NOSE-cz). Materials and Methods: Two-centre prospective instrument validation study. The psychometric properties (reliability, validity, sensitivity) of the Czech version were assessed in 72 patients undergoing (rhino) septoplasty and 39 asymptomatic controls. Results: Internal consistency (Cronbach’s alpha 0.796 and 0.691 before and after surgery, respectively) and test-retest reliability (Pearson’s test, 0.74; P <0.0001) were very good. The instrument showed excellent discrimination between groups (two sample t-test; P <0.0001) and sensitivity (standardised response mean 2.53). Conclusions: The Czech version of NOSE (NOSE-cz) demonstrated good to excellent psychometric properties and its use is recommended for daily clinical practice and research. Keywords: Quality of life – nasal obstruction – validation – NOSE scale – septoplasty
背景:鼻塞是鼻内科最常见的症状之一。2004年,Stewart发表了一种非常简单的鼻塞症状评估仪器(NOSE),该仪器已经被多种语言改编和验证。本研究的目的是验证捷克版问卷(NOSE-cz)。材料和方法:双中心前瞻性仪器验证研究。在72例(犀牛)鼻中隔成形术患者和39例无症状对照中评估捷克版的心理测量特性(信度、效度、灵敏度)。结果:内部一致性(术前、术后Cronbach’s alpha分别为0.796、0.691)、重测信度(Pearson’s test, 0.74;P <0.0001)非常好。该仪器显示出极好的组间判别性(两样本t检验;P <0.0001)和敏感性(标准化反应平均值2.53)。结论:捷克语版NOSE (NOSE-cz)具有良好的心理测量性能,推荐用于日常临床实践和研究。关键词:生活质量;鼻塞;验证
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引用次数: 0
Coexistent parapharyngeal epithelial-myoepithelial carcinoma and bilateral Warthin’s tumors 咽旁上皮-肌上皮癌与双侧沃辛氏瘤共存
Pub Date : 2022-03-22 DOI: 10.48095/ccorl202233
Zuzana Mateášiková, R. Salzman, I. Stárek, J. Michálek
Epithelial-myoepithelial carcinoma (EMEC) is a very rare low-grade malignancy with an incidence of less than 1% of all salivary gland tumors. In the parapharyngeal space, it can arise either from the deep lobe of the parotid gland or from minor salivary glands of the oropharynx. We present a case of a 70-year-old female patient with progressive dysphagia and a bulging of paratonsillar space. A CT scan revealed a cystic formation in the parapharyngeal space and bilateral inhomogeneous tumors in parotid glands. Preoperative FNAB (fine needle aspiration bio­psy) was undiagnostic. Definitive histologic examination after surgical removal confirmed epithelial-myoepithelial carcinoma in the parapharyngeal space and Warthin’s tumors in both parotid glands. Immunohistochemical tests of the EMEC revealed BRAF, COSM476 a COSM775 and PIK3CA mutations, however, no HRAS mutation was detected. This case report shows a rare clinical and radiological presentation that could resemble benign dia­gnosis. Multiple salivary gland tumors are relatively rare conditions. Warthin’s tumor is the most common tumor with this type of behaviour. The coincidence of bilateral Warthin’s tumor of parotid glands with a parapharyngeal epithelial-myoepithelial carcinoma has not been documented in literature so far. Keywords: epithelial-myoepithelial carcinoma – parapharyngeal space cyst – salivary gland – Warthin’s tumor
上皮-肌上皮癌(EMEC)是一种非常罕见的低级别恶性肿瘤,发病率不到所有唾液腺肿瘤的1%。在咽旁间隙,它可以来自腮腺的深叶或口咽的小唾液腺。我们报告一位70岁女性病患,因进行性吞咽困难及旁旁扁桃体肿大。CT扫描显示咽旁间隙囊性形成和双侧腮腺不均匀肿瘤。术前FNAB(细针穿刺活检)未确诊。手术切除后的最终组织学检查证实咽旁间隙上皮-肌上皮癌和两腮腺Warthin肿瘤。EMEC的免疫组化检测显示BRAF、COSM476、COSM775和PIK3CA突变,但未检测到HRAS突变。这个病例报告显示了一个罕见的临床和放射学表现,可能类似于良性诊断。多发性唾液腺肿瘤是相对罕见的疾病。沃辛氏肿瘤是最常见的具有这种行为的肿瘤。双侧腮腺Warthin肿瘤与咽旁上皮-肌上皮癌的同时发生至今尚未见文献报道。关键词:上皮-肌上皮癌咽旁间隙囊肿唾液腺沃辛瘤
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引用次数: 0
Academician Antonín Přecechtěl died 50 years ago Antonín Přecechtěl院士50年前去世了
Pub Date : 2021-12-20 DOI: 10.48095/ccorl2021247
Ivan Kalivoda
Antonín Přecechtěl was born on 6 November 1885 in the village of Srbce in the Prostějov region (Moravia) in a peasant’s family. He graduated from the secondary grammar school in Kroměříž and studied medicine at the Czech Medical Faculty of the Charles-Ferdinand University in Prague. After graduating in 1910, he started his career as a surgeon at prof. Kukula’s surgery clinic in Prague. As a surgeon, he participated in the Balkan Wars and the First World War. In 1918 he began to work at prof. Kutvirt’s ear clinic in Prague. Here he obtained habilitation in otology and pharyngology in 1920, and in 1924 he was appointed associate professor. After Kutvirt’s death, he became the head of the clinic in 1930, and in the same year, he also received habilitation in rhino-laryngology, thus completing the process of unifying the teaching of otorhinolaryngology as one field. He held the position of head of the Otolaryngology Clinic for 30 years. He was a founding member of the Czech Otolaryngological Society (1921) and in the period 1935–1951, he was its chairman. In 1926, as a founding member, he participated in the founding of the prestigious organization Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum. He also participated in the establishment and management of the international journal Otolaryngologia Slavica, and the journal Czechoslovak Otolaryngology began to be published in 1952 on his initiative. The results of his scientific work have been published in almost 400 publications in both domestic and foreign journals. Přecechtěl was also involved in laboratory and experimental research, especially on the vestibular apparatus. In 1954 he was appointed a full member of the Czechoslovak Academy of Sciences, in which he founded the Otolaryngological Laboratory. Professor Přecechtěl created his own otorhinolaryngology school and trained many experts. He died on 5 February 1971, at the age of 85. Keywords: history – Antonín Přecechtěl – remembrance – commemoration – Czech otorhinolaryngology – ENT
Antonín Přecechtěl于1885年11月6日出生在普罗斯特雷约夫地区(摩拉维亚)的一个农民家庭的Srbce村。他毕业于Kroměříž的中学文法学校,并在布拉格查尔斯-费迪南德大学的捷克医学院学习医学。1910年毕业后,他在布拉格库库拉教授的外科诊所开始了他的外科医生生涯。作为一名外科医生,他参加了巴尔干战争和第一次世界大战。1918年,他开始在布拉格库特维尔特教授的耳科诊所工作。1920年,他在这里获得耳鼻喉科的培训,并于1924年被任命为副教授。库特维尔死后,他于1930年成为诊所的负责人,同年,他还接受了鼻喉科的康复训练,从而完成了将耳鼻喉科的教学统一为一个领域的过程。他担任耳鼻喉科门诊主任30年。他是捷克耳鼻喉学会的创始成员(1921年),并在1935年至1951年期间担任主席。1926年,作为创始成员,他参与了著名组织合议耳鼻喉学会(Collegium oto - rhino -喉)的创立。他还参与了国际期刊otolaryngolgia Slavica的创立和管理,并在他的倡议下于1952年开始出版《捷克斯洛伐克耳鼻咽喉学》杂志。他的科研成果在国内外近400种刊物上发表。Přecechtěl也参与了实验室和实验研究,特别是在前庭器官方面。1954年,他被任命为捷克斯洛伐克科学院的正式成员,并在科学院创立了耳鼻喉科实验室。Přecechtěl教授创建了自己的耳鼻喉科学校,培养了许多专家。他于1971年2月5日去世,享年85岁。关键词:历史- Antonín Přecechtěl -记忆-纪念-捷克耳鼻喉科-耳鼻喉科
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引用次数: 0
Vztah mezi presbyakuzí a poruchou kognitivních funkcí ve stáří PDF uzamčeno English info
Pub Date : 2021-12-20 DOI: 10.48095/ccorl2021223
Jakub Fuksa, Milan Profant, M. Chovanec, J. Syka
Age-related hearing loss, presbycusis, is one of the most frequent sensory impairments in the ageing population. It is associated with pathologies of both inner ear and the central parts of the auditory system. Intact cognitive functions are necessary for the proper processing of complex auditory information. Since the beginning of the 80s, there is an increasing amount of evidence linking presbycusis to cognitive impairment and increased risk of dementia. The exact cause, which connects these two pathologies, is still unknown, although there are several hypotheses with various levels of evidence available. This review aims to describe the role of cognitive functions in the auditory processing, to summarize published evidence for a relationship between the hearing loss and cognitive impairment with a possible mechanism, which would explain this link. In addition, we discuss specific features of cognitive assessment in a person with hearing loss and describe the effect of hearing loss treatment, e. g. with hearing aids, cochlear implant and cognitive-hearing training on cognitive functions. Keywords: dementia – hearing loss – presbycusis – cognitive decline
与年龄相关的听力损失,老年性耳聋,是老年人最常见的感觉障碍之一。它与内耳和听觉系统中枢的病理有关。完整的认知功能是正确处理复杂听觉信息的必要条件。自80年代初以来,越来越多的证据表明老年性痴呆与认知障碍和痴呆风险增加有关。连接这两种疾病的确切原因尚不清楚,尽管有几种假设和不同程度的证据。本文旨在阐述认知功能在听觉加工中的作用,总结已发表的有关听力损失与认知障碍之间关系的证据及其可能的机制,以解释这种联系。此外,我们还讨论了听力损失患者认知评估的具体特征,并描述了听力损失治疗的效果,例如:通过助听器、人工耳蜗和认知听力训练来提高认知功能。关键词:痴呆-听力损失-老年性痴呆-认知能力下降
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引用次数: 1
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Otorinolaryngologie a foniatrie
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