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Implementation Of The 5 M And Health Protocol Determinants Of Vaccination Covid-19 Events In The Region Central City Health Center 在区域中心城市卫生中心实施Covid-19疫苗接种事件的5m和卫生协议决定因素
Pub Date : 2023-08-31 DOI: 10.58806/ijhmr.2023.v2i8n06
Herni Alwin Pakaja, Irwan Irwan, Herlina Jusuf
The Indonesian government through the Ministry of Health has made various preventive efforts to reduce the transmission rate of COVID-19 in Indonesia, including implementing the 5M health protocol and promoting the COVID-19 vaccination program for all levels of society. This research was conducted to determine the effect of implementing the 5M health protocol and the determinants of vaccination on the incidence of COVID-19 in the Kota Tengah Public Health Center area, Gorontalo City. This type of research is an analytic survey, cross sectional design, with Chi-Square test and logistic regression test. The independent variables are the 5M Health protocol (Wearing Masks, Washing hands, Keeping distance, Avoiding crowds, Reducing mobility) and the determinants of vaccination (age, sex, education level, occupation, comorbidities, completeness of vaccinations), while the dependent variable is the incidence of COVID-19 . The research was conducted in November and December 2022 with a total sample of 392 people. The sampling technique used was proportional stratified random sampling. The results of the analysis found that of the 11 variables that had been tested, all of them had a significant relationship with the incidence of COVID-19, but only 5 variables had a significant influence on the incidence of COVID-19 in the Kota Tengah Public Health Center area with a P-value = < 0.05 , namely wearing a mask (0.000), keeping a distance (0.000), reducing mobility (0.000), gender (0.012) and completeness of vaccination (0.000). The conclusion from this study I that the variable that has the most influence on the incidence of COVID-19 in the Kota Tengah Public Health Center area is reduced mobility (p-value 0.000; OR 9.560; CI = 4.657-19.626), which means that respondents who never or occasionally reduce their mobility have a 9.6 times risk of being infected with COVID-19. The community should self-awarely adhere to the 5M health protocol and vaccinate so that it can prevent the spread of COVID-19.
印度尼西亚政府通过卫生部采取了各种预防措施,以降低COVID-19在印度尼西亚的传播率,包括实施“500万人健康方案”,并在社会各阶层推广COVID-19疫苗接种方案。本研究旨在确定哥伦塔洛市哥打登加公共卫生中心地区实施5M卫生方案的效果和接种疫苗的决定因素对COVID-19发病率的影响。这类研究采用分析调查,横断面设计,采用卡方检验和logistic回归检验。自变量是5M健康方案(戴口罩、洗手、保持距离、避开人群、减少流动性)和疫苗接种决定因素(年龄、性别、教育水平、职业、合并症、疫苗接种的完整性),因变量是COVID-19的发病率。该研究于2022年11月和12月进行,共有392人参与。抽样方法为比例分层随机抽样。分析结果发现,在已检测的11个变量中,所有变量都与COVID-19发病率有显著关系,但只有5个变量对Kota Tengah公共卫生中心区域的COVID-19发病率有显著影响,p值= < 0.05,即戴口罩(0.000)、保持距离(0.000)、减少活动(0.000)、性别(0.012)和疫苗接种完整性(0.000)。本研究的结论是:对哥打登加公共卫生中心区域COVID-19发病率影响最大的变量是减少流动性(p值0.000;或9.560;CI = 4.657-19.626),这意味着从未或偶尔减少活动的受访者感染COVID-19的风险是其9.6倍。社区应自觉遵守500万人健康方案,接种疫苗,以防止新冠病毒的传播。
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引用次数: 0
Assessment Of The Effect Of Menopause On Thyroid Function In South East,Nigeria 尼日利亚东南部更年期对甲状腺功能影响的评估
Pub Date : 2023-08-31 DOI: 10.58806/ijhmr.2023.v2i8n05
Ogochukwu A Duru, Kelechi R Onyenemezu, Chukwuemelie D Okeke, John C Ubah, Nneoma R Ubah
Menopause marks the end of a woman’s reproductive life and is associated with significant physiological changes. The thyroid gland plays an important role in regulating overall body metabolism including sexual development and reproductive function. Worldwide, thyroid gland diseases are among the most common endocrine disorders in females, especially those in menopause. This study evaluated the effect of menopause on thyroid function. Methodology: It was a case-control study among post-menopausal women in Nnewi, Anambra, Nigeria with pre-menopausal women serving as controls. Sampling was by simple random method and comprised 45 post-menopausal women matched with 45 premenopausal women in a ratio of 1:1. Data was obtained with the use of a semi-structured questionnaire. The subjects’ blood samples were taken and assayed for thyroid stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) by ELISA technique. Their body mass index (BMI) and blood pressure were obtained using standard procedures. Result: The mean serum levels of free T4 and TSH in the menopausal individuals were significantly higher compared to the premenopausal group. Following linear regression analyses with adjustment for age and BMI, the the average level of TSH and free T4 were higher in the study group, while free T3 level was lower. Also, systolic and diastolic blood pressure was significantly higher in the study group than in the control group. Conclusion: The findings suggest that menopause is associated with reduced thyroid function and could as a result play a role in cardiovascular disease play a role in cardiovascular dysfunction among women
更年期标志着女性生殖生命的结束,并与显著的生理变化有关。甲状腺在调节包括性发育和生殖功能在内的全身代谢中起着重要作用。在世界范围内,甲状腺疾病是女性,尤其是绝经期女性最常见的内分泌疾病之一。本研究评估更年期对甲状腺功能的影响。方法:这是一项病例对照研究,研究对象为尼日利亚阿南布拉省奈维市的绝经后妇女,对照组为绝经前妇女。抽样采用简单随机方法,45名绝经后妇女与45名绝经前妇女按1:1的比例配对。使用半结构化问卷获得数据。采用酶联免疫吸附法(ELISA)检测受试者血液中促甲状腺激素(TSH)、甲状腺素(T4)和三碘甲状腺原氨酸(T3)的含量。他们的身体质量指数(BMI)和血压使用标准程序。结果:绝经期个体血清游离T4和TSH水平明显高于绝经前组。经调整年龄和BMI后的线性回归分析,实验组TSH和游离T4平均水平较高,而游离T3水平较低。此外,研究组的收缩压和舒张压明显高于对照组。结论:研究结果表明,更年期与甲状腺功能下降有关,因此可能在女性心血管疾病中起作用
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引用次数: 0
The Effect Of Short Message Service Reminders On Self-Management Of Type 2 Diabetes Mellitus Patients 短信服务提醒对2型糖尿病患者自我管理的影响
Pub Date : 2023-08-31 DOI: 10.58806/ijhmr.2023.v2i8n07
Olivia Maharani Mohamad
Background: Short Message Service (SMS) can be used to increase knowledge of diabetes patients and improve adherence to recommended therapy. Methodology: The study used a Quasi-Experimental method with a Pretest-Posttest Nonequivalent Control Group design involving 40 Prolanis Diabetes Mellitus Type 2 patients, which were divided into a control group and an intervention group. Data collection used a questionnaire which was analyzed by the Mann Whitney test. Results: The results showed that there were differences in self-management in dietary adherence (p=0.008 <0.05) and medication adherence (p=0.031<0.05) before and after being given a short message reminder to patients with type 2 diabetes mellitus at the Kabila Health Center. Conclusion: There is an effect of short message service reminders on the self-management of type 2 diabetes mellitus patients at Kabila Health Center.
背景:短信服务(SMS)可用于增加糖尿病患者的知识和提高对推荐治疗的依从性。方法:采用准实验方法,采用前测后测非等效对照组设计,将40例Prolanis 2型糖尿病患者分为对照组和干预组。数据收集采用问卷调查,并通过曼·惠特尼检验进行分析。结果:卡比拉健康中心对2型糖尿病患者进行短信提醒前后,患者在自我管理方面的饮食依从性(p=0.008 <0.05)和药物依从性(p=0.031<0.05)存在差异。结论:短信提醒对卡比拉保健中心2型糖尿病患者的自我管理有一定的促进作用。
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引用次数: 0
Contemporary Use Of Topical Decongestants: An Indian Perspective 局部减充血剂的当代使用:印度人的观点
Pub Date : 2023-08-31 DOI: 10.58806/ijhmr.2023.v2i8n04
Samir Bhargava, Atul Sharma
Background: Allergic rhinitis and sinusitis are commonly encountered in primary practice, and nasal congestion is a common symptom experienced by these patients. Thus, it is important to address nasal congestion when treating these conditions. Despite the availability of several treatment options, therapy is impacted by adverse effects and patient dissatisfaction. We conducted a survey to evaluate the prescribing practices of physicians treating allergic rhinitis and sinusitis, with a focus on the formulation of topical xylometazoline with moisturizers (hypromellose and sorbitol). Methods: We surveyed the prescribing practices of 545 Indian ear, nose and throat (ENT) physicians for rhinitis and sinusitis to understand the place of the formulation containing xylometazoline and moisturizer (sorbitol, hypromellose) in clinical practice. Towards this, physicians provided their response to a 10-item questionnaire covering prescribing practice and patient satisfaction. Results: Overall, 91% of doctors reported that a decongestant along with a moisturizer would be beneficial to patients with nasal congestion due to allergic rhinitis and sinusitis, and a majority of doctors (89.5%) preferred prescribing xylometazoline with sorbitol and hypromellose. A majority of doctors reported high patient satisfaction with this formulation. Additionally, 78.35% of doctors reported high ratings for the reduction of nasal dryness. Conclusion: The overall satisfaction of doctors and patients is high, indicating that this formulation is an ideal choice for achieving relief from nasal congestion due to AR and sinusitis.
背景:变应性鼻炎和鼻窦炎在初级医疗中很常见,鼻塞是这些患者的常见症状。因此,在治疗这些疾病时解决鼻塞问题是很重要的。尽管有几种治疗选择,但治疗受到不良反应和患者不满的影响。我们进行了一项调查,以评估医生治疗过敏性鼻炎和鼻窦炎的处方做法,重点是外用木美唑啉与保湿剂(羟丙纤维素和山梨醇)的配方。方法:对545名印度耳鼻喉科医师治疗鼻炎和鼻窦炎的处方进行调查,了解含木美唑啉和润肤剂(山梨醇、羟丙纤维素)的处方在临床中的地位。为此,医生们提供了一份包含处方实践和患者满意度的10项调查问卷。结果:总体而言,91%的医生报告说,解充血剂和保湿剂对因过敏性鼻炎和鼻窦炎引起的鼻塞患者有益,大多数医生(89.5%)更倾向于将木美唑啉与山梨醇和羟丙纤维素联合使用。大多数医生报告患者对这种配方的满意度很高。此外,78.35%的医生对缓解鼻干给出了很高的评价。结论:医生和患者总体满意度较高,表明该配方是缓解AR和鼻窦炎引起的鼻塞的理想选择。
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引用次数: 0
The Relationship Of Physical Activity, Gadget Use, And Sleep Time To Adolescent Obesity 体育活动、电子设备使用和睡眠时间与青少年肥胖的关系
Pub Date : 2023-08-31 DOI: 10.58806/ijhmr.2023.v2i8n08
Anwar Pasaribu, Sunarto Kadir, Sylva Flora Ninta Tarigan, Irwan Irwan
Overweight and obesity are a global health problem for both children and adults. The highest number of overweight and obese people in Gorontalo Province in 2017, in all age groups, was highest in Gorontalo City. This study aims to determine the relationship between physical activity, gadget use, and sleep time. This type of research uses a quantitative method with Observational analysis with a Cross-Sectional research design using the Spearman test. The population included in the study were all SMA Negeri 2 Kota Gorontalo students, totaling 1149 students. Sampling was carried out non-randomly using a purposive sampling technique determined using the Slovin formula. So, the sample size for this study was 92 students. The research showed an influence between physical activity and obesity in adolescents with a P-value = 0.010 (<0.05). Based on the results of the study at SMA N 2 Gorontalo City, it was found that there was an influence between playing gadgets and the incidence of obesity in adolescents with a P-value = 0.009 (<0.05). Based on the results of research at SMA N 2 Gorontalo City, it was found that there was an influence between sleep time and the incidence of obesity in adolescents with a P-value = 0.000 (<0.05). The conclusion is that physical activity, use of gadgets, and sleep time are related to obesity in adolescents.
超重和肥胖对儿童和成人来说都是一个全球性的健康问题。2017年,哥伦塔洛省所有年龄组中超重和肥胖人数最多的是哥伦塔洛市。这项研究旨在确定身体活动、电子设备使用和睡眠时间之间的关系。这种类型的研究使用定量方法,观察分析和横断面研究设计,使用斯皮尔曼检验。纳入研究的人群均为SMA Negeri 2 Kota Gorontalo学生,共计1149名学生。抽样是非随机进行的,采用利用斯洛文公式确定的有目的抽样技术。这项研究的样本量是92名学生。研究表明,体育活动与青少年肥胖之间存在显著的关系,p值= 0.010(<0.05)。根据Gorontalo市SMA N 2的研究结果,发现玩电子产品与青少年肥胖发生率之间存在影响,p值= 0.009(<0.05)。根据Gorontalo市SMA N 2的研究结果,发现睡眠时间与青少年肥胖发生率之间存在影响,p值= 0.000(<0.05)。结论是,体育活动、电子产品的使用和睡眠时间与青少年肥胖有关。
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引用次数: 0
Comparative Assessment Of Job Satisfaction Among Frontline Health Care Workers In A Tertiary Hospital In South East Nigeria 尼日利亚东南部某三级医院一线医护人员工作满意度比较评估
Pub Date : 2023-08-21 DOI: 10.58806/ijhmr.2023.v2i8n03
Justice Mgbecheta, Kelechi R Onyenemezu, Chukwuemelie D Okeke, John C Ubah, T. Ezike, Queeneth Edwards
Background: Job satisfaction cuts across facets of mental perception and responses individuals make towards their jobs. They include cognitive, affective, and behavioral components. In light of reducing workforce in the Nigerian healthcare, this study was aimed at comparing the outlook of job satisfaction among healthcare workers in Nnamdi Azikiwe University teaching Hospital, Nnewi, Nigeria. Methods: It was a cross-sectional study design with a sample size of 281 healthcare personnel consisting of doctors, nurses, medical laboratory scientists, pharmacists, physiotherapists, and radiographers using a structured, self-administered questionnaire. The data was analyzed using SPSS version 20. Statistical significance was set at p≤0.05. Results: The study showed that Radiographers and Physiotherapists averagely had the best job satisfaction scores in comparison to other healthcare personnel. Doctors and Nurses were noted to have the worst average scores in relation to other personnel. Conclusion: The disparity in job satisfaction among different professional cadres may be a reflection of disproportionate work expectations, outlooks, and rewards experienced by different professionals in the course of their duties. Favorable and unfavorable work environments and policies may be weighted differently in the work experience of different professionals.
背景:工作满意度跨越了个人对工作的心理感知和反应的各个方面。它们包括认知、情感和行为成分。鉴于尼日利亚医疗保健的劳动力减少,本研究旨在比较尼日利亚Nnamdi Azikiwe大学教学医院医护人员工作满意度的前景。方法:采用横断面研究设计,样本量为281名卫生保健人员,包括医生、护士、医学实验室科学家、药剂师、物理治疗师和放射技师,采用结构化的自我管理问卷。数据采用SPSS version 20进行分析。p≤0.05为差异有统计学意义。结果:研究显示,放射技师和物理治疗师的平均工作满意度得分高于其他医护人员。与其他人员相比,医生和护士的平均得分最低。结论:不同专业干部工作满意度的差异可能反映了不同专业人员在其职责过程中所经历的不相称的工作期望、观点和奖励。在不同的专业人员的工作经历中,有利和不利的工作环境和政策的权重可能不同。
{"title":"Comparative Assessment Of Job Satisfaction Among Frontline Health Care Workers In A Tertiary Hospital In South East Nigeria","authors":"Justice Mgbecheta, Kelechi R Onyenemezu, Chukwuemelie D Okeke, John C Ubah, T. Ezike, Queeneth Edwards","doi":"10.58806/ijhmr.2023.v2i8n03","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i8n03","url":null,"abstract":"Background: Job satisfaction cuts across facets of mental perception and responses individuals make towards their jobs. They include cognitive, affective, and behavioral components. In light of reducing workforce in the Nigerian healthcare, this study was aimed at comparing the outlook of job satisfaction among healthcare workers in Nnamdi Azikiwe University teaching Hospital, Nnewi, Nigeria. Methods: It was a cross-sectional study design with a sample size of 281 healthcare personnel consisting of doctors, nurses, medical laboratory scientists, pharmacists, physiotherapists, and radiographers using a structured, self-administered questionnaire. The data was analyzed using SPSS version 20. Statistical significance was set at p≤0.05. Results: The study showed that Radiographers and Physiotherapists averagely had the best job satisfaction scores in comparison to other healthcare personnel. Doctors and Nurses were noted to have the worst average scores in relation to other personnel. Conclusion: The disparity in job satisfaction among different professional cadres may be a reflection of disproportionate work expectations, outlooks, and rewards experienced by different professionals in the course of their duties. Favorable and unfavorable work environments and policies may be weighted differently in the work experience of different professionals.","PeriodicalId":423982,"journal":{"name":"International Journal Of Health &amp; Medical Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130938897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Crucial Roles of Geospatial Techniques in The COVID-19 Fight : A Systematic Review 地理空间技术在抗击COVID-19中的关键作用:系统综述
Pub Date : 2023-08-18 DOI: 10.58806/ijhmr.2023.v2i8n01
Thi-Quynh Nguyen, Huong Giang Nguyen, Thi Tuyet Mai Nguyen
The Corona Virus Disease 2019 (COVID-19) appeared in Wuhan, China, at the end of 2019, spreading from there across China and the whole world. Such advanced technologies as geospatial techniques have been applied to fight the rapid spread of SARS-CoV-2. This paper aims to review and synthesize the types of applications offered through geospatial techniques to help address different issues related to the fight of the COVID-19 pandemic. The content is presented under four sub-sections; namely the roles of GIS, Remote Sensing, Global Positioning System and Internet Mapping Technologies in the fight of the COVID-19 pandemic. It was found from summarising 73 scientific papers, geospatial techniques have been proven their effectiveness not only in the study of COVID-19 in general, but also in the fight of the pandemic in particular. The wide range of applications offered by geospatial techniques affirms the value of this technique to the COVID-19 fight.
2019年年底,新型冠状病毒病(COVID-19)在中国武汉出现,并从武汉蔓延到中国乃至全球。利用地理空间技术等先进技术应对新冠肺炎的快速传播。本文旨在回顾和综合通过地理空间技术提供的应用类型,以帮助解决与COVID-19大流行有关的不同问题。内容分为四个小节;即地理信息系统、遥感、全球定位系统和互联网地图技术在抗击COVID-19大流行中的作用。通过对73篇科学论文的总结,我们发现,地理空间技术不仅在研究COVID-19方面发挥了作用,而且在防治大流行方面也发挥了作用。地理空间技术提供的广泛应用证实了该技术对抗击COVID-19的价值。
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引用次数: 0
A Case Report Of Isolated Left Zygomatic Arch Fracture: Successful Management By Yoga Prana Vidya (YPV) Healing Protocols 孤立性左颧弓骨折1例:瑜伽Prana Vidya (YPV)治疗方案的成功治疗
Pub Date : 2023-08-18 DOI: 10.58806/ijhmr.2023.v2i8n02
Leelavathi Nayak, Venkata Satyanarayana Nanduri
Introduction: Fractures of the zygomatic bone can present with complicated aesthetic and neurological pathology. Isolated, nondisplaced fractures may be treated without surgery, whereas displaced zygomatic arch fractures are usually treated with surgical reduction this paper presents a case of Zygomatic arch fracture healed successfully without surgical intervention. Method: Case study method is used in this paper, by collecting case data from patient’s medical records, YPV healer’s records, and patient feedback. Results: The redness in the eye and pain in all affected parts reduced within a week of YPV healing. The injury and its effects were fully healed within 1 month of YPV healing without any recurrence of pain or swelling. Conclusions: Yoga Prana Vidya system, which is integrated and holistic, has been found to be successful in the treatment of many types of illnesses. Further research is recommended using appropriate sample and methodology. Practicing doctors and nurses will find it beneficial to receive training in the application of YPV healing protocols to complement their respective professional practices.
颧骨骨折具有复杂的美学和神经病理学。孤立的,非移位的骨折可以不用手术治疗,而移位的颧弓骨折通常用手术复位治疗。本文报道了一例颧弓骨折无需手术治疗而成功愈合的病例。方法:采用个案研究法,从患者病历、YPV治疗师病历和患者反馈中收集病例资料。结果:YPV愈合后一周内,眼红肿及所有受累部位疼痛减轻。创伤及其影响在YPV愈合后1个月内完全愈合,无疼痛或肿胀复发。结论:瑜伽Prana Vidya系统,这是综合和整体,已被发现是成功的治疗许多类型的疾病。建议使用适当的样本和方法进行进一步的研究。执业医生和护士会发现接受YPV治疗方案的应用培训是有益的,以补充他们各自的专业实践。
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引用次数: 0
Knowledge, Attitude, and Perception of Common Skin Health Problems among Secondary Schools Students in Anaocha Local Government Area, Southeast Nigeria 尼日利亚东南部阿纳奥查地方政府区中学生常见皮肤健康问题的知识、态度和认知
Pub Date : 2023-07-30 DOI: 10.58806/ijhmr.2023.v2i7n06
Afamefuna Obumneme Onyeogulu, Kelechi R Onyenemezu, Chukwuemelie Darlington Okeke, John Chiedu Ubah, Tobechukwu Chinenye Ezike, Theophilus Nwanyigor Agbo
Background: Dermatological conditions are commonly associated with low mortality rates, but they significantly contribute to morbidity globally. The burden of certain common skin diseases is remarkably higher among adolescents, and associated with psychosocial and physical impacts. This study was aimed at assessing the knowledge, attitude, and perception of common skin diseases among secondary school students in Anaocha. Methodology: It was a descriptive cross-sectional study among 395 secondary school students in Anaocha Local Government Area of Anambra state using a multistage stratified sampling technique with an interviewer-administered, semi-structured questionnaire. Data analysis was done using SPSS version 25. Results: There were 178 (45.1%) males and 217 (54.9%) females with an average age of 14.27 years ± 1.52. The respondents’ knowledge of acne, tinea capitis, and scabies was found to have an overall score of 43.29% ± 13.26. 78.2% of respondents showed a strong perception of common skin health challenges, and 84.3% showed a decisive attitude toward them. The level of knowledge was significantly associated with the student’s academic class and gender. Conclusion: Overall knowledge of common skin conditions was poor and there was a high rate of misconceptions along with the tendency for self-medication. Though most respondents showed a decisive attitude towards these conditions, there is a high potential for neglect of care for skin diseases in general including sinister ones. Therefore, health education on common skin conditions should be intensified within all secondary schools in Anambra state to improve the knowledge of students on these important conditions.
背景:皮肤疾病通常与低死亡率相关,但它们在全球范围内显著促进了发病率。某些常见皮肤病的负担在青少年中明显更高,并与心理社会和身体影响有关。本研究旨在了解阿纳奥查市中学生对常见皮肤病的认知、态度及认知情况。方法:对阿南布拉州阿纳奥查地方政府区的395名中学生进行了描述性横断面研究,采用多阶段分层抽样技术,采用访谈者管理的半结构化问卷。数据分析采用SPSS 25。结果:男性178例(45.1%),女性217例(54.9%),平均年龄(14.27±1.52)岁。调查对象对痤疮、头癣、疥疮的认知总体得分为43.29%±13.26分。78.2%的受访者对常见的皮肤健康挑战有较强的认知,84.3%的受访者对此持果断态度。知识水平与学生的学术班级和性别显著相关。结论:患者对常见皮肤状况的总体认识较差,存在较高的误解率和自我用药倾向。虽然大多数受访者对这些情况表现出果断的态度,但对包括险恶疾病在内的一般皮肤病的护理忽视的可能性很大。因此,在阿南布拉州的所有中学应加强关于常见皮肤状况的健康教育,以提高学生对这些重要状况的认识。
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引用次数: 0
Drug-Drug Interaction Between Amlodipine And Clarithromycin In Hypertension Rabbits 氨氯地平与克拉霉素在家兔高血压中的相互作用
Pub Date : 2023-07-28 DOI: 10.58806/ijhmr.2023.v2i7n05
Rana Mahmood Ahmad,, Zahraa Kadhim Lafi,, H. Alshaikhli
This study is the first to examine the possibility of pharmacokinetic interaction in blood circulation using amlodipine and clarithromycin as representatives in hypertension rabbits and identify changes. The current study design required rabbits (n=6) for Pharmacokinetics. In group A, rabbits without treatment were used as control. In group B, were administration of a single dose of amlodipine (0.21mg/kg.BW) for 24 hours. Group C, were administered with a single dose of amlodipine (0.21mg/kg/BW.) and clarithromycin (22 mg/kg/BW.) each 6 hr. for 24 hour. The blood samples were collected from (B and C) groups at time intervals of zero, 1, 2, 3, 4, 6, 8, 12, 24, 36, 48, 60, 72, 96, 120, 144 hours and the drug concentrations were estimated using a spectrophotometer and estimated blood pressure using blood pressure cuff with Doppler ultrasound transducer. An increase in C max and AUC in group C (3.52 μg/ml and 130 μg/ml*h) respectively, indicates the improved bioavailability of amlodipine in the presence of clarithromycin compared with group B (2.03 μg/ml and 96.10 μg/ml*h) respectively. Furthermore, reduction in (CL) with an elevation of (Vd) in the presence of clarithromycin (54.94 L/kg/hr. and 4994 L/kg) in group C respectively, compared with group B (74.31 L/kg/hr and 3715 L/kg) respectively. We studied the influence of clarithromycin on the pharmacodynamics of amlodipine in hypertension rabbits. Interaction of amlodipine with multiple doses of clarithromycin produced a high reduction in blood pressure at 9 after administration and the blood pressure continues redaction. In conclusion, the combination of amlodipine with clarithromycin led to the enhancement of the bioavailability of amlodipine by inhibiting the CYP3A4 enzyme leading to producing a hypotension effect with peak plasma concentration effect in hypertension rabbits.
本研究首次以氨氯地平和克拉霉素为代表,探讨高血压家兔血液循环中药代动力学相互作用的可能性,并确定其变化。目前的研究设计需要兔(n=6)进行药代动力学研究。A组以未经处理的家兔为对照。B组给予单剂量氨氯地平(0.21mg/kg.BW) 24小时。C组患者给予单剂量氨氯地平(0.21mg/kg/BW.)和克拉霉素(22 mg/kg/BW.),每6小时一次。24小时。B组和C组分别于0、1、2、3、4、6、8、12、24、36、48、60、72、96、120、144小时采血,用分光光度计测定药物浓度,用带多普勒超声换能器的血压袖带测定血压。C组的cmax和AUC升高(分别为3.52 μg/ml和130 μg/ml*h),表明克拉霉素存在下氨氯地平的生物利用度较B组(分别为2.03 μg/ml和96.10 μg/ml*h)有所提高。此外,在克拉霉素存在下(Vd)升高时(CL)降低(54.94 L/kg/hr)。与B组(74.31 L/kg/hr和3715 L/kg)相比,C组分别为74.31 L/kg和4994 L/kg。研究克拉霉素对高血压家兔氨氯地平药效学的影响。氨氯地平与多剂量克拉霉素的相互作用在给药后9点血压大幅降低,血压继续降低。综上所述,氨氯地平与克拉霉素联用可抑制高血压家兔的CYP3A4酶,从而提高氨氯地平的生物利用度,产生具有血药浓度峰效应的降压作用。
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引用次数: 0
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International Journal Of Health &amp; Medical Research
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