Seneesh Kumar Vikraman, Shasmita Yandamuri, Jay Desai
Transverse or lateral facial clefts are atypical and rare forms of facial clefts identified as Tessier type 7 in the classification system for orofacial clefts. They have an overall incidence of 1 in 60,000 to 300,000 live births. We report a case diagnosed at 22 weeks of gestation. The two-dimensional (2D) ultrasound examination revealed a single live fetus with a persistently open mouth, failure of visualization of lateral commissures, and mild retrognathia. The three-dimensional (3D) surface rendering of the fetal face demonstrated a bilateral horizontal facial cleft that extended from the lateral commissures to the ears. No additional anomalies were identified. Fetal karyotype and whole exome sequencing reports did not reveal any genomic imbalances. The case highlights the importance of 2D oblique and 3D imaging of the fetal face when subtle findings are detected in routine 2D views. A review of the literature is provided to enhance the understanding of the entity.
{"title":"Prenatal Diagnosis of a Case of Asyndromic Tessier Class-7 Bilateral Complete Transverse Facial Cleft: Case Report with Review of Literature","authors":"Seneesh Kumar Vikraman, Shasmita Yandamuri, Jay Desai","doi":"10.1055/s-0044-1779289","DOIUrl":"https://doi.org/10.1055/s-0044-1779289","url":null,"abstract":"Transverse or lateral facial clefts are atypical and rare forms of facial clefts identified as Tessier type 7 in the classification system for orofacial clefts. They have an overall incidence of 1 in 60,000 to 300,000 live births. We report a case diagnosed at 22 weeks of gestation. The two-dimensional (2D) ultrasound examination revealed a single live fetus with a persistently open mouth, failure of visualization of lateral commissures, and mild retrognathia. The three-dimensional (3D) surface rendering of the fetal face demonstrated a bilateral horizontal facial cleft that extended from the lateral commissures to the ears. No additional anomalies were identified. Fetal karyotype and whole exome sequencing reports did not reveal any genomic imbalances. The case highlights the importance of 2D oblique and 3D imaging of the fetal face when subtle findings are detected in routine 2D views. A review of the literature is provided to enhance the understanding of the entity.","PeriodicalId":42412,"journal":{"name":"Journal of Fetal Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prajakta Aloorkar, Gayathri Vemavarapu, Venkatram T., Shantisree R.
Congenital hallux varus (CHV) is an uncommon anomaly of the forefoot where the big toe is positioned medially at the metatarsophalangeal joint, accompanied by a significant gap between the first and second toes. CHV is associated with difficulty in wearing clothes and footwear. CHV can cause pain that hampers the quality of life and can often be aesthetically displeasing.Although prenatal presentation is rare, CHV can be detected by antenatal ultrasound with appropriate foot examination and a high index of suspicion. Early detection and management are recommended for optimizing antenatal and postnatal management as they may reduce the chance of permanent deformity.We are herewith reporting a prenatally detected case of a CHV with polysyndactyly and its management. This is one of the few prenatally reported cases of isolated unilateral foot abnormalities.
{"title":"Congenital Hallux Varus: A Rare Prenatal Detection and Postnatal Management","authors":"Prajakta Aloorkar, Gayathri Vemavarapu, Venkatram T., Shantisree R.","doi":"10.1055/s-0044-1779435","DOIUrl":"https://doi.org/10.1055/s-0044-1779435","url":null,"abstract":"Congenital hallux varus (CHV) is an uncommon anomaly of the forefoot where the big toe is positioned medially at the metatarsophalangeal joint, accompanied by a significant gap between the first and second toes. CHV is associated with difficulty in wearing clothes and footwear. CHV can cause pain that hampers the quality of life and can often be aesthetically displeasing.Although prenatal presentation is rare, CHV can be detected by antenatal ultrasound with appropriate foot examination and a high index of suspicion. Early detection and management are recommended for optimizing antenatal and postnatal management as they may reduce the chance of permanent deformity.We are herewith reporting a prenatally detected case of a CHV with polysyndactyly and its management. This is one of the few prenatally reported cases of isolated unilateral foot abnormalities.","PeriodicalId":42412,"journal":{"name":"Journal of Fetal Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashutosh Gupta, A. Aneja, Neena Bahl, Rupam Arora, R. Sehgal, Pankaj Saini
Monozygotic twins are thought to be identical since they are created from a single fertilized egg, yet there may be differences in their congenital defects, birth weight, and genetic makeup. Asymmetric X chromosome inactivation, unequal gene imprinting, and postzygotic mitotic mistakes including nondisjunction and anaphase lag can all result in heterokaryotypic monochorionic twins. We report a monochorionic twin pregnancy that exhibited stigmata associated with trisomy 18 on postnatal examination despite a low risk of common aneuploidy (trisomy 18) on noninvasive prenatal screening. Short tandem repeat markers were used for postnatal examination to confirm high-grade mosaicism. These markers indicated mosaic trisomy 18 in twin II and normal in twin I, ruling out uniparental disomy and establishing monozygosity in both fetuses. Twin sac amniocentesis is a prenatal diagnostic procedure that can be used to identify discrepant monochorionic twins because chorionic villus sampling, single sac amniocentesis, or cordocentesis may not be able to rule out aneuploidy in the second fetus and may yield a false-negative result. For prompt zygosity diagnosis, chromosomal complement, genetic counseling, and referral for selective fetal reduction, twin sac amniocentesis is recommended.
单卵双胞胎被认为是完全相同的，因为他们是由一个受精卵产生的，但他们的先天缺陷、出生体重和遗传组成可能存在差异。不对称的 X 染色体失活、不平等的基因印记以及合子后有丝分裂错误（包括无丝分裂和无丝分裂滞后）都可能导致异型单绒毛膜双胞胎。我们报告了一例单绒毛膜双胎妊娠，尽管在无创产前筛查中常见的非整倍体（18 三体综合征）风险很低，但在产后检查中却表现出与 18 三体综合征相关的症状。短串联重复标记用于产后检查，以确认高度嵌合。这些标记显示，双胞胎 II 患有嵌合型 18 三体综合征，而双胞胎 I 则正常，从而排除了单亲裂殖症的可能，并确定了两个胎儿的单倍性。由于绒毛取样、单囊羊膜腔穿刺术或脐带穿刺术可能无法排除第二个胎儿的非整倍体，并可能产生假阴性结果，因此双囊羊膜腔穿刺术是一种可用于鉴别差异单绒毛膜双胎的产前诊断方法。為了及時診斷胎兒的合子率、進行染色體補 充、提供遺傳輔導及轉介進行選擇性減胎，建議進行雙胎羊膜腔穿刺。
{"title":"Heterokaryotypic Monochorionic Twin Pregnancy: New Perspective","authors":"Ashutosh Gupta, A. Aneja, Neena Bahl, Rupam Arora, R. Sehgal, Pankaj Saini","doi":"10.1055/s-0044-1780493","DOIUrl":"https://doi.org/10.1055/s-0044-1780493","url":null,"abstract":"Monozygotic twins are thought to be identical since they are created from a single fertilized egg, yet there may be differences in their congenital defects, birth weight, and genetic makeup. Asymmetric X chromosome inactivation, unequal gene imprinting, and postzygotic mitotic mistakes including nondisjunction and anaphase lag can all result in heterokaryotypic monochorionic twins. We report a monochorionic twin pregnancy that exhibited stigmata associated with trisomy 18 on postnatal examination despite a low risk of common aneuploidy (trisomy 18) on noninvasive prenatal screening. Short tandem repeat markers were used for postnatal examination to confirm high-grade mosaicism. These markers indicated mosaic trisomy 18 in twin II and normal in twin I, ruling out uniparental disomy and establishing monozygosity in both fetuses. Twin sac amniocentesis is a prenatal diagnostic procedure that can be used to identify discrepant monochorionic twins because chorionic villus sampling, single sac amniocentesis, or cordocentesis may not be able to rule out aneuploidy in the second fetus and may yield a false-negative result. For prompt zygosity diagnosis, chromosomal complement, genetic counseling, and referral for selective fetal reduction, twin sac amniocentesis is recommended.","PeriodicalId":42412,"journal":{"name":"Journal of Fetal Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140696342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malignant infantile osteopetrosis is a rare case of isolated fetal femoral fracture, a scarcely documented phenomenon in medical literature. Through detailed examination and genetic testing, it unveils malignant infantile osteopetrosis as an unexpected etiology, challenging existing diagnostic paradigms. This groundbreaking case emphasizes the critical role of genetic testing in unraveling complex fetal anomalies and underscores the necessity for comprehensive approaches in prenatal diagnostics, offering new insights into prenatal manifestations of skeletal dysplasias.
{"title":"Malignant Infantile Osteopetrosis Masquerading as Isolated Fetal Femoral Fracture: First Indian Case Report and Review of Literature","authors":"Balusamy Sathyalakshmi, Vanathi Thangavelu Jothi","doi":"10.1055/s-0044-1780491","DOIUrl":"https://doi.org/10.1055/s-0044-1780491","url":null,"abstract":"Malignant infantile osteopetrosis is a rare case of isolated fetal femoral fracture, a scarcely documented phenomenon in medical literature. Through detailed examination and genetic testing, it unveils malignant infantile osteopetrosis as an unexpected etiology, challenging existing diagnostic paradigms. This groundbreaking case emphasizes the critical role of genetic testing in unraveling complex fetal anomalies and underscores the necessity for comprehensive approaches in prenatal diagnostics, offering new insights into prenatal manifestations of skeletal dysplasias.","PeriodicalId":42412,"journal":{"name":"Journal of Fetal Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Binder phenotype (BP) or maxillonasal dysplasia is a developmental disorder of the anterior part of the maxilla and nasal complex and is characterized by a short nose with a flat nasal bridge, short columella, acute nasolabial angle, perialar flatness, convex upper lip, and tendency to a class III malocclusion. The etiology of BP is heterogeneous with diverse features and outcomes. The ultrasound features of BP are midfacial hypoplasia with verticalized nasal bones, short columella with flattened tip and alar wings, and the nasofrontal angle measuring >140 degrees. In this case series, we present seven cases of BP detected antenatally, their varied etiology, management, and outcomes with a 2-year follow-up. We conclude that the diagnosis of facial dysmorphisms, such as BP, brings a lot of apprehension and agony in the parents amounting to multiple tests and counseling sessions. Physiognomy which is the normal familial appearance should be considered before concluding whether the observed feature is normal or pathological. Accurate diagnosis, adequate testing, and personalized counseling will help in the prevention of needless termination of pregnancies and ensure an optimal perinatal outcome.
宾德表型（Binder phenotype，BP）或上颌骨发育不良（maxillonasal dysplasia）是一种上颌骨前部和鼻复合体的发育障碍，其特征是鼻梁短平、鼻小柱短、鼻唇角尖锐、鼻唇周扁平、上唇外凸，以及倾向于 III 级错颌畸形。BP 的病因多种多样，具有不同的特征和结果。BP 的超声波特征是面中部发育不良，鼻骨垂直，鼻翼短小，鼻尖和耳翼扁平，鼻额角大于 140 度。在本病例系列中，我们介绍了七例产前发现的 BP 病例、其不同的病因、处理方法以及两年随访的结果。我们的结论是，面部畸形（如 BP）的诊断会给父母带来很多担忧和痛苦，需要进行多次检查和咨询。在断定所观察到的特征是正常的还是病态的之前，应先考虑正常的家族相貌。准确的诊断、充分的检查和个性化的咨询将有助于避免不必要的终止妊娠，并确保围产期的最佳结果。
{"title":"Binder Phenotype—Prenatal Diagnosis, Management, and Postnatal Outcome: Insights from a Case Series and Updated Review of the Literature","authors":"Brinda Sabu, Dhanya Shenoy, V. R","doi":"10.1055/s-0044-1786170","DOIUrl":"https://doi.org/10.1055/s-0044-1786170","url":null,"abstract":"Binder phenotype (BP) or maxillonasal dysplasia is a developmental disorder of the anterior part of the maxilla and nasal complex and is characterized by a short nose with a flat nasal bridge, short columella, acute nasolabial angle, perialar flatness, convex upper lip, and tendency to a class III malocclusion. The etiology of BP is heterogeneous with diverse features and outcomes. The ultrasound features of BP are midfacial hypoplasia with verticalized nasal bones, short columella with flattened tip and alar wings, and the nasofrontal angle measuring >140 degrees. In this case series, we present seven cases of BP detected antenatally, their varied etiology, management, and outcomes with a 2-year follow-up. We conclude that the diagnosis of facial dysmorphisms, such as BP, brings a lot of apprehension and agony in the parents amounting to multiple tests and counseling sessions. Physiognomy which is the normal familial appearance should be considered before concluding whether the observed feature is normal or pathological. Accurate diagnosis, adequate testing, and personalized counseling will help in the prevention of needless termination of pregnancies and ensure an optimal perinatal outcome.","PeriodicalId":42412,"journal":{"name":"Journal of Fetal Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140698520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vidhika Berwal, V. Krishnan, M. Eapen, Vidya Chandraprabha, R. Elayedatt
Rhabdoid tumors of the kidney are highly lethal malignancies of infancy. We report the prenatal detection of this renal tumor in a fetus in the third trimester of pregnancy. Ultrasonologically, the tumor appeared as a large mass in the left renal area associated with severe polyhydramnios. Though the sonographic features alone did not allow distinction from a benign lesion, tumor extension into the subcutaneous plane favored the possibility of a malignant renal tumor and this was confirmed postnatally on histopathology.
{"title":"Prenatal Diagnosis of Renal Rhabdoid Tumor: A Rare Malignant Neoplasm","authors":"Vidhika Berwal, V. Krishnan, M. Eapen, Vidya Chandraprabha, R. Elayedatt","doi":"10.1055/s-0044-1780492","DOIUrl":"https://doi.org/10.1055/s-0044-1780492","url":null,"abstract":"Rhabdoid tumors of the kidney are highly lethal malignancies of infancy. We report the prenatal detection of this renal tumor in a fetus in the third trimester of pregnancy. Ultrasonologically, the tumor appeared as a large mass in the left renal area associated with severe polyhydramnios. Though the sonographic features alone did not allow distinction from a benign lesion, tumor extension into the subcutaneous plane favored the possibility of a malignant renal tumor and this was confirmed postnatally on histopathology.","PeriodicalId":42412,"journal":{"name":"Journal of Fetal Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140719486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gourisankar Rudrapal, Adinarayan Makkam, V. Krishnan
Fetal lower urinary tract obstruction (LUTO) in a male fetus could cause detrimental effects to the KUB (kidney, ureter, and bladder) system from back-pressure changes as well as to the lungs from reduced amniotic fluid. In a carefully selected case where the obstruction causes progressive damage, a therapeutic intervention could be lifesaving. In utero vesico-amniotic shunting has been shown to improve perinatal pulmonary survival, but evidence on improvement of renal outcomes with this procedure is lacking. More recently, fetal cystoscopic laser fulguration has been shown to be beneficial in longer-term survival and renal outcomes. These interventions carry significant risk, and therefore patient selection and optimal timing are key. This guideline lists the intricacies of patient selection, relevant counseling points and procedural details.
{"title":"SFM Fetal Therapy Practice Guidelines: Fetal Cystoscopic Laser Ablation","authors":"Gourisankar Rudrapal, Adinarayan Makkam, V. Krishnan","doi":"10.1055/s-0044-1782222","DOIUrl":"https://doi.org/10.1055/s-0044-1782222","url":null,"abstract":"Fetal lower urinary tract obstruction (LUTO) in a male fetus could cause detrimental effects to the KUB (kidney, ureter, and bladder) system from back-pressure changes as well as to the lungs from reduced amniotic fluid. In a carefully selected case where the obstruction causes progressive damage, a therapeutic intervention could be lifesaving. In utero vesico-amniotic shunting has been shown to improve perinatal pulmonary survival, but evidence on improvement of renal outcomes with this procedure is lacking. More recently, fetal cystoscopic laser fulguration has been shown to be beneficial in longer-term survival and renal outcomes. These interventions carry significant risk, and therefore patient selection and optimal timing are key. This guideline lists the intricacies of patient selection, relevant counseling points and procedural details.","PeriodicalId":42412,"journal":{"name":"Journal of Fetal Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. A. Sharma, Seneesh Kv, Latika Chawla, Anubhuti Rana
Fetal laser therapy was first used in complicated monochorionic pregnancies such as twin-to-twin transfusion syndrome or twin-reversed arterial perfusion sequence. There are some other less common indications such as amniotic band syndrome, chorioangiomas, lower urinary tract obstructions, sacrococcygeal teratomas, and fetal thoracic masses. These practice guidelines discuss the indications, contraindications, and risks of the procedure along with information for patients and draft consent form.
{"title":"SFM Fetal Therapy Practice Guidelines: Fetal Interstitial Laser","authors":"K. A. Sharma, Seneesh Kv, Latika Chawla, Anubhuti Rana","doi":"10.1055/s-0044-1778740","DOIUrl":"https://doi.org/10.1055/s-0044-1778740","url":null,"abstract":"Fetal laser therapy was first used in complicated monochorionic pregnancies such as twin-to-twin transfusion syndrome or twin-reversed arterial perfusion sequence. There are some other less common indications such as amniotic band syndrome, chorioangiomas, lower urinary tract obstructions, sacrococcygeal teratomas, and fetal thoracic masses. These practice guidelines discuss the indications, contraindications, and risks of the procedure along with information for patients and draft consent form.","PeriodicalId":42412,"journal":{"name":"Journal of Fetal Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140231078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fetoscopic laser coagulation is offered as a method of treatment for twin-to-twin transfusion syndrome or twin anemia polycythemia sequence. It involves laser ablation of intercommunicating superficial blood vessels on the surface of the placenta, under sono-endoscopic control. Preterm labor and preterm prelabor rupture of the membranes are known complications. The results depend on the expertise of the surgeon, location of the placenta, indication for treatment, severity of disease, and growth of babies. The chances of both babies surviving are around 65% and one baby surviving is 85%.
{"title":"SFM Fetal Therapy Practice Guidelines: Fetoscopic Laser Photocoagulation in Monochorionic Twins","authors":"V. Dadhwal, Krishnan Manikandan, Anubhuti Rana","doi":"10.1055/s-0044-1779006","DOIUrl":"https://doi.org/10.1055/s-0044-1779006","url":null,"abstract":"Fetoscopic laser coagulation is offered as a method of treatment for twin-to-twin transfusion syndrome or twin anemia polycythemia sequence. It involves laser ablation of intercommunicating superficial blood vessels on the surface of the placenta, under sono-endoscopic control. Preterm labor and preterm prelabor rupture of the membranes are known complications. The results depend on the expertise of the surgeon, location of the placenta, indication for treatment, severity of disease, and growth of babies. The chances of both babies surviving are around 65% and one baby surviving is 85%.","PeriodicalId":42412,"journal":{"name":"Journal of Fetal Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anders Einum, Philip von Brandis, Elisabeth Leirgul, Cathrine Ebbing
Abstract A parous woman with a monochorionic twin pregnancy presented at gestational week 25 with an uncommon situation. One twin had developed hydrops, but not due to placental transfusion syndrome. The twin had a supraventricular tachyarrhythmia, a rare and severe complication that untreated would threaten the lives of both twins. We present the longitudinal Doppler ultrasound findings when assessing the hemodynamic effects of the arrhythmia and the transplacental treatment with antiarrhythmic medication (flecainide), and how the arrhythmia and the conversion to normal rhythm influenced umbilical and liver circulation in the fetus.
{"title":"Monochorionic Twin Pregnancy Complicated by Arrhythmia in One Twin: Longitudinal Hemodynamic Effects of Flecainide Cardioversion Assessed by Fetal Venous Doppler","authors":"Anders Einum, Philip von Brandis, Elisabeth Leirgul, Cathrine Ebbing","doi":"10.1055/s-0043-1774753","DOIUrl":"https://doi.org/10.1055/s-0043-1774753","url":null,"abstract":"Abstract A parous woman with a monochorionic twin pregnancy presented at gestational week 25 with an uncommon situation. One twin had developed hydrops, but not due to placental transfusion syndrome. The twin had a supraventricular tachyarrhythmia, a rare and severe complication that untreated would threaten the lives of both twins. We present the longitudinal Doppler ultrasound findings when assessing the hemodynamic effects of the arrhythmia and the transplacental treatment with antiarrhythmic medication (flecainide), and how the arrhythmia and the conversion to normal rhythm influenced umbilical and liver circulation in the fetus.","PeriodicalId":42412,"journal":{"name":"Journal of Fetal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135679618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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