Pub Date : 2022-11-01DOI: 10.4274/haseki.galenos.2022.8177
M. Unal, Iffet Dagdelen Duran, E. Karakiliç, Mehtap Navdar Başaran, S. Guler
Aim: The association between high levels of anti-thyroid antibodies and the extent of destruction of thyroid tissue is well documented. The aim of the present study was to analyze the relationship between anti-thyroid antibodies, thyroid hormones, and sonographic parenchymal changes. Methods: The study was designed as a case-control study. Four hundred and seventy-five patients with HT and 98 healthy subjects were included in the study. Serum levels of free thyroxine (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone, and anti-thyroid antibodies (anti-thyroid peroxidase antibodies and anti-thyroglobulin antibodies) were measured. The ultrasonographic results of the patients were also recorded. Results: Serum levels of anti-TPO and anti-Tg were significantly associated with hypoechogenicity, heterogeneity, and pseudonodulation (p<0.001). There was no significant difference between the two groups in terms of cyst and nodule formation, however, a significant difference was found in terms of thyroid volume (p<0.001). Thyroid volumes were higher in the HT group. As serum anti-TPO levels increased in the HT group, parenchymal hypoechogenicity increased (p<0.001). Conclusion: Ultrasonography is a non-invasive method that provides information about the inflammatory activity of the thyroid gland. Significantly reduced echogenicity, heterogeneity, and multifocal pseudonodular infiltration were indicators of inflammatory activity and were associated with higher anti-TPO levels. Anti-TPO and ultrasonographical changes may be useful in the follow-up of Hashimoto’s thyroiditis.
{"title":"Association Between Thyroid Antibodies and Ultrasonic Imaging in Patients with Hashimoto’s Thyroiditis","authors":"M. Unal, Iffet Dagdelen Duran, E. Karakiliç, Mehtap Navdar Başaran, S. Guler","doi":"10.4274/haseki.galenos.2022.8177","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8177","url":null,"abstract":"Aim: The association between high levels of anti-thyroid antibodies and the extent of destruction of thyroid tissue is well documented. The aim of the present study was to analyze the relationship between anti-thyroid antibodies, thyroid hormones, and sonographic parenchymal changes. Methods: The study was designed as a case-control study. Four hundred and seventy-five patients with HT and 98 healthy subjects were included in the study. Serum levels of free thyroxine (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone, and anti-thyroid antibodies (anti-thyroid peroxidase antibodies and anti-thyroglobulin antibodies) were measured. The ultrasonographic results of the patients were also recorded. Results: Serum levels of anti-TPO and anti-Tg were significantly associated with hypoechogenicity, heterogeneity, and pseudonodulation (p<0.001). There was no significant difference between the two groups in terms of cyst and nodule formation, however, a significant difference was found in terms of thyroid volume (p<0.001). Thyroid volumes were higher in the HT group. As serum anti-TPO levels increased in the HT group, parenchymal hypoechogenicity increased (p<0.001). Conclusion: Ultrasonography is a non-invasive method that provides information about the inflammatory activity of the thyroid gland. Significantly reduced echogenicity, heterogeneity, and multifocal pseudonodular infiltration were indicators of inflammatory activity and were associated with higher anti-TPO levels. Anti-TPO and ultrasonographical changes may be useful in the follow-up of Hashimoto’s thyroiditis.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"63 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84795319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.4274/haseki.galenos.2022.8258
R. Şavkın, Izgi Guven, Nihal Buker
Aim: The level of health literacy and cyberchondria of healthcare providers can affect service beneficiaries, and the influence of health literacy and cyberchondria on physical activity and body awareness remains unclear. The aim of this study was to determine the health literacy and cyberchondria levels of healthcare workers and examine their relationship with physical activity level and body awareness. Methods: This cross-sectional study was conducted between August and November 2021 on 168 healthcare professionals working at the university hospital. The Turkish Health Literacy scale (TSOY-32), Cyberchondria scale, Body Awareness Questionnaire (BAQ), and International Physical Activity Questionnaire-Short Form (IPAQ-SF) were used for outcome measurements. Results: The TSOY-32 and Cyberchondria scale total scores were 37.76±7.98 and 63.83±19.45, respectively. There were low positive and significant correlations with TSOY-32, BAQ (r=0.213, p=0.006) and IPAQ-SF (r=0.162, p=0.036), while a low negative correlation was found between cyberchondria level and BAQ (r=-0.179, p=0.022) and IPAQ-SF (r=-0.193, p=0.013). Conclusion: This study shows that, unlike predicted, health professionals did not have perfect health literacy and were found to have moderate cyberchondria. Physical activity and body awareness may affect increasing health literacy and reducing cyberchondria, which will empower individuals to make beneficial health decisions.
{"title":"Health Literacy and Cyberchondria Levels in Healthcare Workers and Their Relationship with Body Awareness and Physical Activity","authors":"R. Şavkın, Izgi Guven, Nihal Buker","doi":"10.4274/haseki.galenos.2022.8258","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8258","url":null,"abstract":"Aim: The level of health literacy and cyberchondria of healthcare providers can affect service beneficiaries, and the influence of health literacy and cyberchondria on physical activity and body awareness remains unclear. The aim of this study was to determine the health literacy and cyberchondria levels of healthcare workers and examine their relationship with physical activity level and body awareness. Methods: This cross-sectional study was conducted between August and November 2021 on 168 healthcare professionals working at the university hospital. The Turkish Health Literacy scale (TSOY-32), Cyberchondria scale, Body Awareness Questionnaire (BAQ), and International Physical Activity Questionnaire-Short Form (IPAQ-SF) were used for outcome measurements. Results: The TSOY-32 and Cyberchondria scale total scores were 37.76±7.98 and 63.83±19.45, respectively. There were low positive and significant correlations with TSOY-32, BAQ (r=0.213, p=0.006) and IPAQ-SF (r=0.162, p=0.036), while a low negative correlation was found between cyberchondria level and BAQ (r=-0.179, p=0.022) and IPAQ-SF (r=-0.193, p=0.013). Conclusion: This study shows that, unlike predicted, health professionals did not have perfect health literacy and were found to have moderate cyberchondria. Physical activity and body awareness may affect increasing health literacy and reducing cyberchondria, which will empower individuals to make beneficial health decisions.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"49 17","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72390796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.4274/haseki.galenos.2022.8245
Omer Demir, H. Şal, Mirac Ozalp, M. Topbaş
{"title":"Investigation of the Change in the Incidence of Neural Tube Defects in the Eastern Black Sea Region of Turkey by Years and its Relationship with Folic Acid Use: A Case-control Study","authors":"Omer Demir, H. Şal, Mirac Ozalp, M. Topbaş","doi":"10.4274/haseki.galenos.2022.8245","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8245","url":null,"abstract":"","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"14 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73828714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.4274/haseki.galenos.2022.8019
Yonca Sevim, E. Cebeci, Ozlem Persil Ozkan, Y. Savaş, S. Ozturk, G. Kiziltan
Aim: There is a need to understand autosomal dominant polycystic kidney disease (ADPKD) patients’ dietary habits since dietary interventions may have potential effects on ADPKD. In this study, we aimed to analyze the relationship between dietary nutrient intake and total kidney volume (TKV). Methods: This cross-sectional study was conducted on 54 ADPKD patients recruited from the Nephrology outpatient clinic between June and July 2014. TKV was determined by magnetic-resonance imaging and general characteristics, biochemical and urinary parameters were determined. The nutrient intakes of patients were calculated using the three-day dietary records obtained on three consecutive days. Results: The total kidney-volume median was found to be 1407 mL. Patients’ total dietary energy and protein intakes were 25.8±9.4 kcal/kg, 0.9±0.3 g/kg, respectively. The percentage of carbohydrates, protein, and fat in energy was 49±7%, 14±3%, 37±7%, respectively. The mean intakes of thiamin, riboflavin, B6, calcium, magnesium, and zinc were sufficient, the mean dietary potassium intake was insufficient; and sodium intake was excessive in both sexes. In females, there was a negative but weak correlation between dietary vitamin C intake and TKV. In males, a negative but weak correlation was found between TKV and dietary intake of fiber, water, vitamin B6, vitamin K, magnesium, and iron. Conclusions: Dietary micronutrient intake may affect TKV according to sex.
{"title":"The Relationship Between Dietary Intakes and Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease Dietary Intake and Polycystic Kidney Volume","authors":"Yonca Sevim, E. Cebeci, Ozlem Persil Ozkan, Y. Savaş, S. Ozturk, G. Kiziltan","doi":"10.4274/haseki.galenos.2022.8019","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8019","url":null,"abstract":"Aim: There is a need to understand autosomal dominant polycystic kidney disease (ADPKD) patients’ dietary habits since dietary interventions may have potential effects on ADPKD. In this study, we aimed to analyze the relationship between dietary nutrient intake and total kidney volume (TKV). Methods: This cross-sectional study was conducted on 54 ADPKD patients recruited from the Nephrology outpatient clinic between June and July 2014. TKV was determined by magnetic-resonance imaging and general characteristics, biochemical and urinary parameters were determined. The nutrient intakes of patients were calculated using the three-day dietary records obtained on three consecutive days. Results: The total kidney-volume median was found to be 1407 mL. Patients’ total dietary energy and protein intakes were 25.8±9.4 kcal/kg, 0.9±0.3 g/kg, respectively. The percentage of carbohydrates, protein, and fat in energy was 49±7%, 14±3%, 37±7%, respectively. The mean intakes of thiamin, riboflavin, B6, calcium, magnesium, and zinc were sufficient, the mean dietary potassium intake was insufficient; and sodium intake was excessive in both sexes. In females, there was a negative but weak correlation between dietary vitamin C intake and TKV. In males, a negative but weak correlation was found between TKV and dietary intake of fiber, water, vitamin B6, vitamin K, magnesium, and iron. Conclusions: Dietary micronutrient intake may affect TKV according to sex.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"54 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90965572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.4274/haseki.galenos.2022.8098
Ozlem Kara, A. Kilitçi
Aim: One of the underlying causes of cisplatin-induced hepatotoxicity is oxidative stress. We assessed the effect of an antioxidant, resveratrol, on cisplatin-induced damage in the rat liver. Methods: The project-starting date was designed as 01.10.2020 and the project-ending date was planned as 01.04.2021. Three groups were created with 30 female Wistar-Albino rats: In group 1 (control group), 1 mL of 0.9% NaCl (saline) was administered intraperitoneally for 3 days. In group 2 (cisplatin group), 7.5 mg/kg intraperitoneal cisplatin was given for 3 days. In group 3 (cisplatin + resveratrol group), 7.5 mg/kg cisplatin and 10 mg/kg resveratrol were given via the intraperitoneal route. The livers were surgically extirpated in all the groups. In both blood and tissues, malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were measured. Also, toxicity markers such as hepatocyte damage (cellular changes), inflammation, hemorrhage, congestion, fibrosis, disorganization of the hepatic cords, and necrosis were assessed by examining the preparations prepared from hepatic tissue with light microscopy and immunohistochemistry. Results: Histopathological tissue damage was significantly higher in group 2 than in other groups (p 0.03). MDA levels were significantly higher and the activities of SOD and CAT were lower in group 2 than in the other groups (p=0.04 and p=0.01, respectively). Conclusion: According to our short-term findings, resveratrol might be an effective molecule for preventing the harmful effects of cisplatin in the rat liver.
{"title":"The Protective Effect of Resveratrol on Cisplatin Induced Damage in Rat Liver","authors":"Ozlem Kara, A. Kilitçi","doi":"10.4274/haseki.galenos.2022.8098","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8098","url":null,"abstract":"Aim: One of the underlying causes of cisplatin-induced hepatotoxicity is oxidative stress. We assessed the effect of an antioxidant, resveratrol, on cisplatin-induced damage in the rat liver. Methods: The project-starting date was designed as 01.10.2020 and the project-ending date was planned as 01.04.2021. Three groups were created with 30 female Wistar-Albino rats: In group 1 (control group), 1 mL of 0.9% NaCl (saline) was administered intraperitoneally for 3 days. In group 2 (cisplatin group), 7.5 mg/kg intraperitoneal cisplatin was given for 3 days. In group 3 (cisplatin + resveratrol group), 7.5 mg/kg cisplatin and 10 mg/kg resveratrol were given via the intraperitoneal route. The livers were surgically extirpated in all the groups. In both blood and tissues, malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were measured. Also, toxicity markers such as hepatocyte damage (cellular changes), inflammation, hemorrhage, congestion, fibrosis, disorganization of the hepatic cords, and necrosis were assessed by examining the preparations prepared from hepatic tissue with light microscopy and immunohistochemistry. Results: Histopathological tissue damage was significantly higher in group 2 than in other groups (p 0.03). MDA levels were significantly higher and the activities of SOD and CAT were lower in group 2 than in the other groups (p=0.04 and p=0.01, respectively). Conclusion: According to our short-term findings, resveratrol might be an effective molecule for preventing the harmful effects of cisplatin in the rat liver.","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"10 5","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72413558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.4274/haseki.galenos.2022.8372
Y. Aksoy, Ozkan Saydam, N. Çıtak, C. Sezen, V. Erdoğu, L. Cansever, M. Bedirhan, M. Metin, A. Kutluk, A. Pekçolaklar
{"title":"The Long-term Outcomes of Completion Pneumonectomy from a Tertiary Center","authors":"Y. Aksoy, Ozkan Saydam, N. Çıtak, C. Sezen, V. Erdoğu, L. Cansever, M. Bedirhan, M. Metin, A. Kutluk, A. Pekçolaklar","doi":"10.4274/haseki.galenos.2022.8372","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2022.8372","url":null,"abstract":"","PeriodicalId":42416,"journal":{"name":"Haseki TIp Bulteni-Medical Bulletin of Haseki","volume":"68 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86658538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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