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Pregnant women with previous bariatric surgery are at high risk of preeclampsia: A multicenter case series and narrative literature review 既往做过减肥手术的孕妇患先兆子痫的风险高:一项多中心病例系列和叙述性文献综述
IF 0.2 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-01-01 DOI: 10.14390/jsshp.hrp2021-014
M. Morikawa, Mana Obata-Yasuoka, T. Miyake, M. Kasai, Yuzo Uchida, Hiromi Hamada, T. Kimura, H. Watari
Aim: This study aimed to clarify outcomes of pregnancies in women with previous bariatric surgery (BS). Methods: A national questionnaire was conducted targeting all 408 perinatal institutions in Japan. Reponses were obtained from 229 institutions, of which four reported a total of five singleton pregnancies and subsequent deliveries in women with previous BS in 2018. Outcomes of these women (BS group) were investigated. Case presentations: One woman (20.0%) delivered without preeclampsia prior to undergoing BS. Among the five women, median maternal age was 36 years, and median interval between previous BS and conception was 28 months. Mean maternal body mass index decreased by 10.5 between BS and conception and increased by 4.57 between conception and delivery. Three women (60.0%) developed preeclampsia (hypertension and proteinuria), two women had chronic hypertension at conception that developed into superimposed preeclampsia, and one woman had new-onset preeclampsia. Three women (60.0%) had type 2 diabetes mellitus (including overt diabetes in pregnancy), and none had new-onset gestational diabetes mellitus. One woman had a preterm delivery at 32 gestational weeks via cesarean section due to abruptio placentae caused by preeclampsia. All five women gave birth to live appropriate-for-gestational age infants with no abnormalities. Conclusion: The incidence of preeclampsia is high among pregnant women with previous BS who have diabetes mellitus at conception.
目的:本研究旨在阐明既往减肥手术(BS)妇女的妊娠结局。方法:对日本408家围产机构进行问卷调查。我们从229家机构获得了反馈,其中4家机构报告称,2018年有5名患有BS的女性出现单胎妊娠和随后的分娩。观察这些妇女(BS组)的预后。病例介绍:1名妇女(20.0%)在接受BS手术前没有子痫前期。在这5名妇女中,产妇年龄中位数为36岁,先前BS和受孕之间的中位数间隔为28个月。孕妇的平均体重指数在怀孕和分娩之间下降了10.5,在怀孕和分娩之间上升了4.57。3名妇女(60.0%)出现子痫前期(高血压和蛋白尿),2名妇女在怀孕时患有慢性高血压,并发展为叠加子痫前期,1名妇女出现新发子痫前期。3名妇女(60.0%)患有2型糖尿病(包括妊娠期显性糖尿病),无新发妊娠糖尿病。一名妇女因先兆子痫引起的胎盘早剥而在妊娠32周时通过剖宫产术早产。这五名妇女都生下了与胎龄相符的婴儿,没有任何异常。结论:妊娠期合并糖尿病的BS孕妇子痫前期发生率较高。
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引用次数: 0
Super-obese pregnancy - understanding the difference from a normal pregnancy and using early multidisciplinary intervention can lead to good outcomes: a case report 超级肥胖妊娠——了解与正常妊娠的区别,并采用早期多学科干预可以带来良好的结果:一份病例报告
IF 0.2 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-01-01 DOI: 10.14390/jsshp.hrp2021-002
T. Arai, S. Tanabe, I. Honda, A. Kohyama
Super-obesity (defined as a body mass index > 50 kg /m2) is quite rare in Japan, and associated with various perinatal complications. Here we report a case of a 30-year-old nulliparous woman with a body mass index of 55.2. Obstetricians, anesthesiologists, physicians, and dietitians provided information and counseling from the early stage of pregnancy, given the potential difficulties during pregnancy and labor. She gained only 2 kg during the pregnancy, and the pregnancy course was uneventful except for the emergence of gestational diabetes and initiation of insulin therapy. To address the difficulties associated with super-obesity, three fetal anatomical scans were performed, a bariatric ward bed and operating table were prepared, and an epidural catheter was inserted early in labor. At 40 weeks of gestation, a baby was delivered vaginally after spontaneous labor onset. Although uterine contractions were difficult to detect, the measures taken made it possible to manage labor without any notable complications.
超级肥胖(定义为体重指数超过50 kg /m2)在日本相当罕见,并与各种围产期并发症有关。我们报告一例30岁未生育妇女,体重指数为55.2。考虑到怀孕和分娩期间的潜在困难,产科医生、麻醉师、内科医生和营养师从怀孕早期就提供了信息和咨询。她在怀孕期间只增加了2公斤,除了出现妊娠期糖尿病和开始胰岛素治疗外,整个怀孕过程都很顺利。为了解决与超级肥胖相关的困难,我们进行了三次胎儿解剖扫描,准备了肥胖病房床和手术台,并在分娩早期插入硬膜外导管。在妊娠40周时,一名婴儿在自然分娩后顺产。虽然子宫收缩很难发现,但所采取的措施使分娩没有任何明显的并发症。
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引用次数: 0
Influence of platelet counts on postpartum hemorrhage in elective cesarean section for Japanese twins 血小板计数对日本双胎择期剖宫产术后出血的影响
IF 0.2 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-01-01 DOI: 10.14390/jsshp.hrp2021-005
Yoshie Shibata, Miwa Miyazaki, Z. Hayashi, Shunji Suzuki
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引用次数: 1
Diagnosis and management of fetal growth restriction and uteroplacental dysfunction in hypertensive disorders of pregnancy in Japan: a nationwide survey by the Japan Society for the Study of Hypertension in Pregnancy (JSSHP) 日本妊娠期高血压疾病中胎儿生长受限和子宫胎盘功能障碍的诊断和处理:日本妊娠期高血压研究协会(JSSHP)的一项全国性调查
IF 0.2 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-01-01 DOI: 10.14390/jsshp.hrp2021-010
K. Mimura, K. Takagi, Hirotada Suzuki, T. Iriyama, H. Seki
1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2Perinatal Center, Division of Maternal and Fetal Medicine, Jichi Medical University, Saitama Medical Center, Saitama, Japan, 3Departments of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan, 4Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, 5Center for Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Saitama, Japan Hypertension Research In Pregnancy
1日本大阪水田市大阪大学医学院妇产科;2日本埼玉市埼玉市医科大学母胎医学部围产期中心;3日本栃木市日一医科大学医学院妇产科;4日本东京大学医学部妇产科;5日本东京市母胎新生儿医学中心;日本,埼玉医科大学,埼玉医学中心,妊娠高血压研究
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引用次数: 0
High serum concentrations of lipopolysaccharide binding protein in pregnancies with pre-eclampsia 妊娠子痫前期血清脂多糖结合蛋白的高浓度
IF 0.2 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-01-01 DOI: 10.14390/jsshp.hrp2021-013
Y. Sakabe, H. Nishizawa, Asuka Kato, Hikari Yoshizawa, Yoshiteru Noda, Akiko Ohwaki, T. Sekiya, Takuma Fujii, H. Kurahashi
Aim: Pre-eclampsia is considered a multi-factorial disease, in which both fetal and maternal factors are involved in its onset. In this study, we aimed to test the longstanding hypothesis that the immune response to bacterial endotoxin could explain the etiology of pre-eclampsia. Methods: Serum lipopolysaccharide binding protein (LBP) concentrations and the vaginal microbiome were compared between subjects with pre-eclampsia and those with normotensive pregnancies. Results: Serum LBP concentrations were higher in subjects with pre-eclampsia compared to those with normotensive pregnancies. LBP concentrations were poorly correlated with disease onset, blood pressure, birthweight, and placental weight. Moreover, there was no evidence of bacterial species specific to pre-eclampsia based on a comparative analysis of the vaginal microbiome of subjects with pre-eclampsia and those with normotensive pregnancies. Conclusion: Serum LBP concentrations were significantly higher in subjects with pre-eclampsia compared to those with normotensive pregnancies. The clinical significance of high serum LBP concentrations in pre-eclampsia requires further investigation.
目的:先兆子痫被认为是一种多因素疾病,其中胎儿和母体因素均参与其发病。在这项研究中,我们旨在验证长期存在的假设,即对细菌内毒素的免疫反应可以解释先兆子痫的病因。方法:比较子痫前期和正常妊娠孕妇血清脂多糖结合蛋白(LBP)浓度和阴道微生物组。结果:子痫前期受试者的血清LBP浓度高于正常妊娠的受试者。LBP浓度与疾病发病、血压、出生体重和胎盘重量相关性较差。此外,根据对子痫前期受试者和正常妊娠受试者阴道微生物组的比较分析,没有证据表明子痫前期患者特有的细菌种类。结论:子痫前期患者血清LBP浓度明显高于正常妊娠患者。高血LBP浓度在子痫前期的临床意义有待进一步研究。
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引用次数: 0
Journal Awards for the Year 2019 2019年度期刊奖
IF 0.2 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2020-11-30 DOI: 10.14390/jsshp.8.31
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引用次数: 0
Intrauterine gauze or balloon tamponade for the management of postpartum hemorrhage due to uterine atony during maternal transportation 宫内纱布或球囊填塞治疗产妇运输过程中子宫张力紧张引起的产后出血
IF 0.2 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2020-11-30 DOI: 10.14390/jsshp.hrp2020-003
Toru Kobayashi, Toshitaka Tanaka, M. Kawata, K. Oguma, Saki Ito, N. Matsuzawa, Y. Murase, Shotaro Yata, Satomi Tanaka, H. Kaneda
Aim: This study aimed to evaluate the effectiveness of intrauterine gauze or balloon tamponade for the management of postpartum hemorrhage due to uterine atony during maternal transportation from private clinics to higher-level facilities. Methods: A total of 1,428 patients were transported to the Department of Obstetrics, Juntendo University Shizuoka Hospital, between January 2008 and December 2019. Among these, 42 patients had postpartum hemorrhage due to uterine atony. Of the 42 patients, 29 (69.0%) were treated with intrauterine gauze or balloon tamponade before transportation (tamponade group); no intrauterine packing was performed in the remaining 13 (31.0%) (non-tamponade group). The primary outcome was the rate of critical obstetrical hemorrhage at hospital arrival. Secondary outcomes were blood loss before and after transportation, hemoglobin, platelets, fibrinogen, amount of blood transfusion, and rate of transfusion. Results: The rate of critical obstetrical hemorrhage was significantly lower in the tamponade group (34.5% (10/29)) compared to the non-tamponade group (76.9% (10/13)). Moreover, total blood loss during transportation and after hospital arrival was significantly lower in the tamponade group (487 ± 331 g) compared to the non-tamponade group (1,199 ± 1,012 g).
目的:本研究旨在评价宫内纱布或宫内球囊填塞治疗产妇在从私人诊所转到高级医疗机构的过程中因子宫紧张性产后出血的效果。方法:2008年1月至2019年12月,共有1428名患者被送往俊天道大学静冈县医院产科。其中42例因子宫张力所致产后出血。42例患者中29例(69.0%)在转运前行宫内纱布或球囊填塞(填塞组);其余13例(31.0%)未行宫内填塞(非填塞组)。主要观察指标是到达医院时产科大出血的发生率。次要结果是运输前后的失血量、血红蛋白、血小板、纤维蛋白原、输血量和输血率。结果:填塞组产科危重出血发生率(34.5%(10/29))明显低于非填塞组(76.9%(10/13))。此外,与非填塞组(1199±1012 g)相比,填塞组在运输过程中和到达医院后的总失血量(487±331 g)显著降低。
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引用次数: 0
Committee for Academic Affairs JSSHP Research Award 2020 Clinical Research and Basic Research 学术委员会JSSHP研究奖2020年临床研究和基础研究
IF 0.2 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2020-11-30 DOI: 10.14390/jsshp.8.33
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引用次数: 0
Pathophysiological roles of ADMA-mediated endothelial injury in hypertensive disorders of pregnancy ADMA介导的内皮损伤在妊娠期高血压疾病中的病理生理作用
IF 0.2 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2020-11-30 DOI: 10.14390/jsshp.hrp2019-013
Takashi Kobayashi, S. Ueda, M. Takagi, M. Kihara, Yusuke Suzuki
Hypertensive disorders of pregnancy (HDP) represent a major cause of maternal and neonatal morbidity and mortality. Studies conducted over the last decade have improved our understanding of the potential mechanisms underlying HDP pathogenesis. The first step in HDP is reduced uteroplacental perfusion as a result of abnormal extravillous trophoblast invasion of spiral arterioles. Subsequent placental ischemia leads to maternal vascular endothelial dysfunction that may be caused by an imbalance between pro- and anti-angiogenic factors, enhanced formation of vasocontractile factors such as endothelin and thromboxane, increased vascular sensitivity to angiotensin II, and/or decreased formation of vasodilators such as nitric oxide (NO) and prostaglandin I2. NO is one of the major mediators from the endothelium, and its production is modified by endogenous NO synthase inhibitors such as asymmetric dimethylarginine (ADMA). ADMA levels are generally higher in patients with cardiovascular and metabolic diseases and widely recognized as a prognostic marker for major cardiovascular events and mortality. Recent studies have found ADMA levels to be higher in patients with preeclampsia. In addition, multiple studies indicate that elevated ADMA in early stages of pregnancy might predict the development of preeclampsia. Finally, ADMA has been found to be associated with uterine artery flow disturbance. Collectively, these findings strongly suggest that elevated ADMA-mediated endothelial dysfunction could be a causative factor for HDP. In this review, we discuss the biology of ADMA, with a particular focus on its potential role in HDP.
妊娠期高血压疾病(HDP)是孕产妇和新生儿发病率和死亡率的主要原因。过去十年进行的研究提高了我们对HDP发病机制潜在机制的理解。HDP的第一步是由于螺旋小动脉的异常绒毛外滋养层侵袭而导致子宫胎盘灌注减少。随后的胎盘缺血导致母体血管内皮功能障碍,这可能是由促血管生成因子和抗血管生成因子之间的失衡、血管收缩因子如内皮素和血栓素的形成增强、血管对血管紧张素II的敏感性增加和/或血管舒张剂如一氧化氮(NO)和前列腺素I2的形成减少引起的。NO是来自内皮的主要介质之一,其产生受到内源性NO合成酶抑制剂如不对称二甲基精氨酸(ADMA)的修饰。ADMA水平在心血管和代谢性疾病患者中通常较高,并被广泛认为是主要心血管事件和死亡率的预后标志。最近的研究发现,先兆子痫患者的ADMA水平更高。此外,多项研究表明,妊娠早期ADMA升高可能预示先兆子痫的发展。最后,ADMA被发现与子宫动脉血流紊乱有关。总之,这些发现有力地表明,ADMA介导的内皮功能障碍升高可能是HDP的致病因素。在这篇综述中,我们讨论了ADMA的生物学,特别是它在HDP中的潜在作用。
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引用次数: 1
Best Reviewer Awards 最佳评论家奖
IF 0.2 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2020-11-30 DOI: 10.14390/jsshp.8.32
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引用次数: 0
期刊
Hypertension Research in Pregnancy
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