Pub Date : 2021-01-15DOI: 10.14390/JSSHP.HRP2020-017
K. Sagawa, Shunji Suzuki, S. Takeda, K. Kinoshita
Many facilities in Japan currently perform elective cesarean section for term singleton breech presentation, and young doctors training in obstetrics and gynecology may not have had a chance to experience vaginal breech delivery. However, vaginal breech delivery remains an option if comprehensive informed consent is obtained. To reduce the incidence of nuchal arm, “transverse figure 8 breech delivery (TF8 maneuver)” has been widely recommended in Japan. This review discusses trends in mode of breech delivery in Japan, with a focus on the TF8 maneuver.
{"title":"Trends in mode of breech delivery in Japan","authors":"K. Sagawa, Shunji Suzuki, S. Takeda, K. Kinoshita","doi":"10.14390/JSSHP.HRP2020-017","DOIUrl":"https://doi.org/10.14390/JSSHP.HRP2020-017","url":null,"abstract":"Many facilities in Japan currently perform elective cesarean section for term singleton breech presentation, and young doctors training in obstetrics and gynecology may not have had a chance to experience vaginal breech delivery. However, vaginal breech delivery remains an option if comprehensive informed consent is obtained. To reduce the incidence of nuchal arm, “transverse figure 8 breech delivery (TF8 maneuver)” has been widely recommended in Japan. This review discusses trends in mode of breech delivery in Japan, with a focus on the TF8 maneuver.","PeriodicalId":42505,"journal":{"name":"Hypertension Research in Pregnancy","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47844790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.14390/JSSHP.HRP2020-016
H. Shinagawa, Ryosei Shikano, A. Takagi, K. Kuromaki
We describe the emergency measures taken in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in an obstetrics ward in Japan. In April 2020, two midwives in our obstetric ward were diagnosed with SARS-CoV-2 infection. We immediately closed the ward and performed polymerase chain reaction (PCR) testing for 25 patients and 42 staff members who had possible contact with the midwives. Pregnant women at or near term were referred to nearby obstetric facilities. One patient, who delivered before the midwives were diagnosed, and her neonate tested positive for SARS-CoV-2. All other tested patients and staff had negative PCR test results. In total, 14 pregnant women at term and 15 at 34–36 weeks gestation were referred to other facilities. Of these, 13 delivered in transfer destinations and 16 delivered in our hospital after a 14-day temporary closure of the ward. Our prompt measures successfully prevented the nosocomial spread of coronavirus disease.
{"title":"Preventive measures against the spread of nosocomial COVID-19 infection: a report of experiences in an obstetric facility at a regional hospital in Japan","authors":"H. Shinagawa, Ryosei Shikano, A. Takagi, K. Kuromaki","doi":"10.14390/JSSHP.HRP2020-016","DOIUrl":"https://doi.org/10.14390/JSSHP.HRP2020-016","url":null,"abstract":"We describe the emergency measures taken in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in an obstetrics ward in Japan. In April 2020, two midwives in our obstetric ward were diagnosed with SARS-CoV-2 infection. We immediately closed the ward and performed polymerase chain reaction (PCR) testing for 25 patients and 42 staff members who had possible contact with the midwives. Pregnant women at or near term were referred to nearby obstetric facilities. One patient, who delivered before the midwives were diagnosed, and her neonate tested positive for SARS-CoV-2. All other tested patients and staff had negative PCR test results. In total, 14 pregnant women at term and 15 at 34–36 weeks gestation were referred to other facilities. Of these, 13 delivered in transfer destinations and 16 delivered in our hospital after a 14-day temporary closure of the ward. Our prompt measures successfully prevented the nosocomial spread of coronavirus disease.","PeriodicalId":42505,"journal":{"name":"Hypertension Research in Pregnancy","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66621361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.14390/jsshp.hrp2021-015
R. Kurashina, S. Akira, H. Kaseki, Shunji Suzuki
{"title":"Gasless laparoscopic ovarian cystectomy for pregnant women","authors":"R. Kurashina, S. Akira, H. Kaseki, Shunji Suzuki","doi":"10.14390/jsshp.hrp2021-015","DOIUrl":"https://doi.org/10.14390/jsshp.hrp2021-015","url":null,"abstract":"","PeriodicalId":42505,"journal":{"name":"Hypertension Research in Pregnancy","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66621492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.14390/jsshp.hrp2021-011
R. Kurashina, Shunji Suzuki
We examined the association between ‘specified expectant mothers (SEMs; pregnant women with social problems)’ at our institute and their mental status at one month after delivery. We examined 890 pregnant women who delivered at ≥ 37 weeks of gestation at our institute between January 2019 and October 2019. We excluded mothers with mental disorders requiring medication and whose children were hospitalized in the neonatal intensive care unit. During the study period, there were 148 SEMs with healthy babies (16.6%). The frequency of screening positive on the Japanese version of the Mother-to-Infant Bonding Scale and the Edinburgh Postnatal Depression Scale was higher in SEMs than in non-SEMs (P = 0.04 and 0.02). In addition, there was a strong positive correlation between scores on the two scales in SEMs (r2 = 0.41, P < 0.01). The present results indicate the quantitatively clarify of the mental vulnerabilities in SEMs.
我们研究了特定准妈妈(SEMs);有社会问题的孕妇和产后一个月的精神状况。我们检查了2019年1月至2019年10月期间在我们研究所分娩的890名妊娠≥37周的孕妇。我们排除了需要药物治疗的有精神障碍且其孩子在新生儿重症监护病房住院的母亲。在研究期间，有148名有健康婴儿的sem(16.6%)。日本版《母婴依恋量表》和《爱丁堡产后抑郁量表》筛选阳性的频率在中小企业组高于非中小企业组(P = 0.04和0.02)。此外，两种量表的SEMs得分之间存在较强的正相关(r2 = 0.41, P < 0.01)。本研究结果为中小企业心理脆弱性的定量研究提供了依据。
{"title":"Postpartum Mental Status in Women with Social Problems at a Japanese perinatal center","authors":"R. Kurashina, Shunji Suzuki","doi":"10.14390/jsshp.hrp2021-011","DOIUrl":"https://doi.org/10.14390/jsshp.hrp2021-011","url":null,"abstract":"We examined the association between ‘specified expectant mothers (SEMs; pregnant women with social problems)’ at our institute and their mental status at one month after delivery. We examined 890 pregnant women who delivered at ≥ 37 weeks of gestation at our institute between January 2019 and October 2019. We excluded mothers with mental disorders requiring medication and whose children were hospitalized in the neonatal intensive care unit. During the study period, there were 148 SEMs with healthy babies (16.6%). The frequency of screening positive on the Japanese version of the Mother-to-Infant Bonding Scale and the Edinburgh Postnatal Depression Scale was higher in SEMs than in non-SEMs (P = 0.04 and 0.02). In addition, there was a strong positive correlation between scores on the two scales in SEMs (r2 = 0.41, P < 0.01). The present results indicate the quantitatively clarify of the mental vulnerabilities in SEMs.","PeriodicalId":42505,"journal":{"name":"Hypertension Research in Pregnancy","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66621857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.14390/jsshp.hrp2021-007
Hirotada Suzuki, A. Ohkuchi, K. Horie, S. Nagayama, M. Ogoyama, R. Usui, Hironori Takahashi, Hiroyuki Fujiwara
Aim: A questionnaire survey was conducted to establish whether opportunistic salpingectomy has been performed at cesarean delivery or is intended in the future and also to clarify the steps taken to achieve the goal of performing opportunistic salpingectomy at cesarean delivery in Japan. Methods: We distributed anonymous questionnaires on opportunistic salpingectomy at cesarean delivery to registered physicians of the Maternal Fetal Intensive Care Unit Liaison Council of Japan using a mailing list in 2019. Answer sheets were returned by fax with an unscripted name. Results: Valid responses were obtained from 68 physicians; 28% ( n = 19/68) performed opportunistic salpingectomy at cesarean delivery, while 16% ( n = 8/49) hoped to conduct opportunistic salpingectomy in the future. Most of the physicians performing opportunistic salpingectomy (74%: n = 14/19) had conducted salpingectomy as one of the permanent surgical contraception procedures provided for by law without the approval of an Ethics Committee. Conclusions: Opportunistic salpingectomy at cesarean delivery to reduce the risk of ovarian, fallopian tube, and peritoneal carcinoma in patients at average risk has not yet been widely practiced in Japan. Approximately 25% of physicians have performed opportunistic salpingectomy, 75% of whom conducted this procedure instead of tubal ligation for pregnant women who requested sterilization at cesarean delivery.
{"title":"Opportunistic salpingectomy at cesarean delivery in Japan: A questionnaire for registered physicians of the MFICU Liaison Council","authors":"Hirotada Suzuki, A. Ohkuchi, K. Horie, S. Nagayama, M. Ogoyama, R. Usui, Hironori Takahashi, Hiroyuki Fujiwara","doi":"10.14390/jsshp.hrp2021-007","DOIUrl":"https://doi.org/10.14390/jsshp.hrp2021-007","url":null,"abstract":"Aim: A questionnaire survey was conducted to establish whether opportunistic salpingectomy has been performed at cesarean delivery or is intended in the future and also to clarify the steps taken to achieve the goal of performing opportunistic salpingectomy at cesarean delivery in Japan. Methods: We distributed anonymous questionnaires on opportunistic salpingectomy at cesarean delivery to registered physicians of the Maternal Fetal Intensive Care Unit Liaison Council of Japan using a mailing list in 2019. Answer sheets were returned by fax with an unscripted name. Results: Valid responses were obtained from 68 physicians; 28% ( n = 19/68) performed opportunistic salpingectomy at cesarean delivery, while 16% ( n = 8/49) hoped to conduct opportunistic salpingectomy in the future. Most of the physicians performing opportunistic salpingectomy (74%: n = 14/19) had conducted salpingectomy as one of the permanent surgical contraception procedures provided for by law without the approval of an Ethics Committee. Conclusions: Opportunistic salpingectomy at cesarean delivery to reduce the risk of ovarian, fallopian tube, and peritoneal carcinoma in patients at average risk has not yet been widely practiced in Japan. Approximately 25% of physicians have performed opportunistic salpingectomy, 75% of whom conducted this procedure instead of tubal ligation for pregnant women who requested sterilization at cesarean delivery.","PeriodicalId":42505,"journal":{"name":"Hypertension Research in Pregnancy","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66621527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.14390/jsshp.hrp2021-014
M. Morikawa, Mana Obata-Yasuoka, T. Miyake, M. Kasai, Yuzo Uchida, Hiromi Hamada, T. Kimura, H. Watari
Aim: This study aimed to clarify outcomes of pregnancies in women with previous bariatric surgery (BS). Methods: A national questionnaire was conducted targeting all 408 perinatal institutions in Japan. Reponses were obtained from 229 institutions, of which four reported a total of five singleton pregnancies and subsequent deliveries in women with previous BS in 2018. Outcomes of these women (BS group) were investigated. Case presentations: One woman (20.0%) delivered without preeclampsia prior to undergoing BS. Among the five women, median maternal age was 36 years, and median interval between previous BS and conception was 28 months. Mean maternal body mass index decreased by 10.5 between BS and conception and increased by 4.57 between conception and delivery. Three women (60.0%) developed preeclampsia (hypertension and proteinuria), two women had chronic hypertension at conception that developed into superimposed preeclampsia, and one woman had new-onset preeclampsia. Three women (60.0%) had type 2 diabetes mellitus (including overt diabetes in pregnancy), and none had new-onset gestational diabetes mellitus. One woman had a preterm delivery at 32 gestational weeks via cesarean section due to abruptio placentae caused by preeclampsia. All five women gave birth to live appropriate-for-gestational age infants with no abnormalities. Conclusion: The incidence of preeclampsia is high among pregnant women with previous BS who have diabetes mellitus at conception.
{"title":"Pregnant women with previous bariatric surgery are at high risk of preeclampsia: A multicenter case series and narrative literature review","authors":"M. Morikawa, Mana Obata-Yasuoka, T. Miyake, M. Kasai, Yuzo Uchida, Hiromi Hamada, T. Kimura, H. Watari","doi":"10.14390/jsshp.hrp2021-014","DOIUrl":"https://doi.org/10.14390/jsshp.hrp2021-014","url":null,"abstract":"Aim: This study aimed to clarify outcomes of pregnancies in women with previous bariatric surgery (BS). Methods: A national questionnaire was conducted targeting all 408 perinatal institutions in Japan. Reponses were obtained from 229 institutions, of which four reported a total of five singleton pregnancies and subsequent deliveries in women with previous BS in 2018. Outcomes of these women (BS group) were investigated. Case presentations: One woman (20.0%) delivered without preeclampsia prior to undergoing BS. Among the five women, median maternal age was 36 years, and median interval between previous BS and conception was 28 months. Mean maternal body mass index decreased by 10.5 between BS and conception and increased by 4.57 between conception and delivery. Three women (60.0%) developed preeclampsia (hypertension and proteinuria), two women had chronic hypertension at conception that developed into superimposed preeclampsia, and one woman had new-onset preeclampsia. Three women (60.0%) had type 2 diabetes mellitus (including overt diabetes in pregnancy), and none had new-onset gestational diabetes mellitus. One woman had a preterm delivery at 32 gestational weeks via cesarean section due to abruptio placentae caused by preeclampsia. All five women gave birth to live appropriate-for-gestational age infants with no abnormalities. Conclusion: The incidence of preeclampsia is high among pregnant women with previous BS who have diabetes mellitus at conception.","PeriodicalId":42505,"journal":{"name":"Hypertension Research in Pregnancy","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66621444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.14390/jsshp.hrp2021-002
T. Arai, S. Tanabe, I. Honda, A. Kohyama
Super-obesity (defined as a body mass index > 50 kg /m2) is quite rare in Japan, and associated with various perinatal complications. Here we report a case of a 30-year-old nulliparous woman with a body mass index of 55.2. Obstetricians, anesthesiologists, physicians, and dietitians provided information and counseling from the early stage of pregnancy, given the potential difficulties during pregnancy and labor. She gained only 2 kg during the pregnancy, and the pregnancy course was uneventful except for the emergence of gestational diabetes and initiation of insulin therapy. To address the difficulties associated with super-obesity, three fetal anatomical scans were performed, a bariatric ward bed and operating table were prepared, and an epidural catheter was inserted early in labor. At 40 weeks of gestation, a baby was delivered vaginally after spontaneous labor onset. Although uterine contractions were difficult to detect, the measures taken made it possible to manage labor without any notable complications.
超级肥胖(定义为体重指数超过50 kg /m2)在日本相当罕见，并与各种围产期并发症有关。我们报告一例30岁未生育妇女，体重指数为55.2。考虑到怀孕和分娩期间的潜在困难，产科医生、麻醉师、内科医生和营养师从怀孕早期就提供了信息和咨询。她在怀孕期间只增加了2公斤，除了出现妊娠期糖尿病和开始胰岛素治疗外，整个怀孕过程都很顺利。为了解决与超级肥胖相关的困难，我们进行了三次胎儿解剖扫描，准备了肥胖病房床和手术台，并在分娩早期插入硬膜外导管。在妊娠40周时，一名婴儿在自然分娩后顺产。虽然子宫收缩很难发现，但所采取的措施使分娩没有任何明显的并发症。
{"title":"Super-obese pregnancy - understanding the difference from a normal pregnancy and using early multidisciplinary intervention can lead to good outcomes: a case report","authors":"T. Arai, S. Tanabe, I. Honda, A. Kohyama","doi":"10.14390/jsshp.hrp2021-002","DOIUrl":"https://doi.org/10.14390/jsshp.hrp2021-002","url":null,"abstract":"Super-obesity (defined as a body mass index > 50 kg /m2) is quite rare in Japan, and associated with various perinatal complications. Here we report a case of a 30-year-old nulliparous woman with a body mass index of 55.2. Obstetricians, anesthesiologists, physicians, and dietitians provided information and counseling from the early stage of pregnancy, given the potential difficulties during pregnancy and labor. She gained only 2 kg during the pregnancy, and the pregnancy course was uneventful except for the emergence of gestational diabetes and initiation of insulin therapy. To address the difficulties associated with super-obesity, three fetal anatomical scans were performed, a bariatric ward bed and operating table were prepared, and an epidural catheter was inserted early in labor. At 40 weeks of gestation, a baby was delivered vaginally after spontaneous labor onset. Although uterine contractions were difficult to detect, the measures taken made it possible to manage labor without any notable complications.","PeriodicalId":42505,"journal":{"name":"Hypertension Research in Pregnancy","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66621414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.14390/jsshp.hrp2021-005
Yoshie Shibata, Miwa Miyazaki, Z. Hayashi, Shunji Suzuki
{"title":"Influence of platelet counts on postpartum hemorrhage in elective cesarean section for Japanese twins","authors":"Yoshie Shibata, Miwa Miyazaki, Z. Hayashi, Shunji Suzuki","doi":"10.14390/jsshp.hrp2021-005","DOIUrl":"https://doi.org/10.14390/jsshp.hrp2021-005","url":null,"abstract":"","PeriodicalId":42505,"journal":{"name":"Hypertension Research in Pregnancy","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66621473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.14390/jsshp.hrp2021-010
K. Mimura, K. Takagi, Hirotada Suzuki, T. Iriyama, H. Seki
1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2Perinatal Center, Division of Maternal and Fetal Medicine, Jichi Medical University, Saitama Medical Center, Saitama, Japan, 3Departments of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan, 4Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, 5Center for Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Saitama, Japan Hypertension Research In Pregnancy
{"title":"Diagnosis and management of fetal growth restriction and uteroplacental dysfunction in hypertensive disorders of pregnancy in Japan: a nationwide survey by the Japan Society for the Study of Hypertension in Pregnancy (JSSHP)","authors":"K. Mimura, K. Takagi, Hirotada Suzuki, T. Iriyama, H. Seki","doi":"10.14390/jsshp.hrp2021-010","DOIUrl":"https://doi.org/10.14390/jsshp.hrp2021-010","url":null,"abstract":"1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2Perinatal Center, Division of Maternal and Fetal Medicine, Jichi Medical University, Saitama Medical Center, Saitama, Japan, 3Departments of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan, 4Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, 5Center for Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Saitama, Japan Hypertension Research In Pregnancy","PeriodicalId":42505,"journal":{"name":"Hypertension Research in Pregnancy","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66621715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.14390/jsshp.hrp2021-013
Y. Sakabe, H. Nishizawa, Asuka Kato, Hikari Yoshizawa, Yoshiteru Noda, Akiko Ohwaki, T. Sekiya, Takuma Fujii, H. Kurahashi
Aim: Pre-eclampsia is considered a multi-factorial disease, in which both fetal and maternal factors are involved in its onset. In this study, we aimed to test the longstanding hypothesis that the immune response to bacterial endotoxin could explain the etiology of pre-eclampsia. Methods: Serum lipopolysaccharide binding protein (LBP) concentrations and the vaginal microbiome were compared between subjects with pre-eclampsia and those with normotensive pregnancies. Results: Serum LBP concentrations were higher in subjects with pre-eclampsia compared to those with normotensive pregnancies. LBP concentrations were poorly correlated with disease onset, blood pressure, birthweight, and placental weight. Moreover, there was no evidence of bacterial species specific to pre-eclampsia based on a comparative analysis of the vaginal microbiome of subjects with pre-eclampsia and those with normotensive pregnancies. Conclusion: Serum LBP concentrations were significantly higher in subjects with pre-eclampsia compared to those with normotensive pregnancies. The clinical significance of high serum LBP concentrations in pre-eclampsia requires further investigation.
{"title":"High serum concentrations of lipopolysaccharide binding protein in pregnancies with pre-eclampsia","authors":"Y. Sakabe, H. Nishizawa, Asuka Kato, Hikari Yoshizawa, Yoshiteru Noda, Akiko Ohwaki, T. Sekiya, Takuma Fujii, H. Kurahashi","doi":"10.14390/jsshp.hrp2021-013","DOIUrl":"https://doi.org/10.14390/jsshp.hrp2021-013","url":null,"abstract":"Aim: Pre-eclampsia is considered a multi-factorial disease, in which both fetal and maternal factors are involved in its onset. In this study, we aimed to test the longstanding hypothesis that the immune response to bacterial endotoxin could explain the etiology of pre-eclampsia. Methods: Serum lipopolysaccharide binding protein (LBP) concentrations and the vaginal microbiome were compared between subjects with pre-eclampsia and those with normotensive pregnancies. Results: Serum LBP concentrations were higher in subjects with pre-eclampsia compared to those with normotensive pregnancies. LBP concentrations were poorly correlated with disease onset, blood pressure, birthweight, and placental weight. Moreover, there was no evidence of bacterial species specific to pre-eclampsia based on a comparative analysis of the vaginal microbiome of subjects with pre-eclampsia and those with normotensive pregnancies. Conclusion: Serum LBP concentrations were significantly higher in subjects with pre-eclampsia compared to those with normotensive pregnancies. The clinical significance of high serum LBP concentrations in pre-eclampsia requires further investigation.","PeriodicalId":42505,"journal":{"name":"Hypertension Research in Pregnancy","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66621891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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