Pub Date : 2023-01-01DOI: 10.4103/ajoim.ajoim_23_22
Sonali Mallik, Amanpreet Kaur, Sarada Suna
Systemic vascular diseases frequently involve the respiratory system leading to inflammation of varying-sized vessels in the lungs by various immunological mechanisms. Granulomatosis with polyangiitis (Wegner’s granulomatosis) is one of the rare vascular diseases involving medium and small vessels in various organs. In typical cases, the upper and lower respiratory tract and kidneys are involved producing granulomatous inflammation of small arteries leading to necrotizing vasculitis usually associated with antineutrophil cytoplasmic antibodies (ANCA). Abnormal chest X-rays are seen in almost 70% of the patients during the course of the disease which includes nodules, infiltrate, and necrosis with subsequent cavitation. In rare cases, it may mimic the radiological features of pneumonia thus making the diagnosis difficult. So, here we present a case of a 53-year-old male who presented with necrotizing pneumonia with parapneumonic effusion later found out to be a case of C ANCA positive granulomatosis with polyangiitis.
{"title":"A case of granulomatosis with polyangiitis presenting as necrotizing pneumonia: A rare case report","authors":"Sonali Mallik, Amanpreet Kaur, Sarada Suna","doi":"10.4103/ajoim.ajoim_23_22","DOIUrl":"https://doi.org/10.4103/ajoim.ajoim_23_22","url":null,"abstract":"Systemic vascular diseases frequently involve the respiratory system leading to inflammation of varying-sized vessels in the lungs by various immunological mechanisms. Granulomatosis with polyangiitis (Wegner’s granulomatosis) is one of the rare vascular diseases involving medium and small vessels in various organs. In typical cases, the upper and lower respiratory tract and kidneys are involved producing granulomatous inflammation of small arteries leading to necrotizing vasculitis usually associated with antineutrophil cytoplasmic antibodies (ANCA). Abnormal chest X-rays are seen in almost 70% of the patients during the course of the disease which includes nodules, infiltrate, and necrosis with subsequent cavitation. In rare cases, it may mimic the radiological features of pneumonia thus making the diagnosis difficult. So, here we present a case of a 53-year-old male who presented with necrotizing pneumonia with parapneumonic effusion later found out to be a case of C ANCA positive granulomatosis with polyangiitis.","PeriodicalId":426816,"journal":{"name":"Assam Journal of Internal Medicine","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117229924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajoim.ajoim_20_22
S. Shrivastava, P. Shrivastava
Acknowledging the dearth in the research arena and deficiencies in the technology sector to promote public health standards, the World Health Assembly and the other member states adopted a global strategy and plan of action on public health, innovation, and intellectual property in 2008. Since the adoption of the policy, some progress has been observed in minimizing the caseload resulting because of diseases that predominantly affect disadvantaged or vulnerable sections of the community. Realizing the prevailing gap on different fronts of the global strategy, the World Health Organization has authorized an external agency to perform a holistic and exhaustive evaluation of the implementation of different aspects. To conclude, the health sector has many shortcomings in the area of improving the health indicators of the masses, and it becomes even more important in cases of developing nations. Owing to the presence of numerous public health challenges in the region, it is extremely important to prioritize the issues and deal with them in a systematic manner to improve the quality of life of the general population.
{"title":"Evaluating the global strategy and plan of action on public health, innovation, and intellectual property: World Health Organization","authors":"S. Shrivastava, P. Shrivastava","doi":"10.4103/ajoim.ajoim_20_22","DOIUrl":"https://doi.org/10.4103/ajoim.ajoim_20_22","url":null,"abstract":"Acknowledging the dearth in the research arena and deficiencies in the technology sector to promote public health standards, the World Health Assembly and the other member states adopted a global strategy and plan of action on public health, innovation, and intellectual property in 2008. Since the adoption of the policy, some progress has been observed in minimizing the caseload resulting because of diseases that predominantly affect disadvantaged or vulnerable sections of the community. Realizing the prevailing gap on different fronts of the global strategy, the World Health Organization has authorized an external agency to perform a holistic and exhaustive evaluation of the implementation of different aspects. To conclude, the health sector has many shortcomings in the area of improving the health indicators of the masses, and it becomes even more important in cases of developing nations. Owing to the presence of numerous public health challenges in the region, it is extremely important to prioritize the issues and deal with them in a systematic manner to improve the quality of life of the general population.","PeriodicalId":426816,"journal":{"name":"Assam Journal of Internal Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115763489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajoim.ajoim_6_23
Yukti Bansal, A. Patra, B. Kalita
Neuromyelitis optica (NMO) is an autoimmune disease of central nervous system with extensive clinical presentations but based on the international consensus diagnostic criteria 2015. The horizon has broadened to a larger entity called NMOSD or NMO spectrum disorders. Nonneurological systemic autoimmune diseases especially thyroid disorders are commonly associated with NMOSD, among which Hashimoto’s thyroiditis is common, whereas not much literature is available regarding the association of Graves’ disease with NMOSD. A 38-year-old male presented with acute onset upper motor neuron quadriparesis along with features of hyperthyroidism with a prior history of sudden onset bilateral decreased vision of both eyes 3 years back. Magnetic resonance imaging (MRI) showed T2 hyperintensity involving cervicodorsal cord from C4 to D6 indicating a longitudinally extensive transverse myelitis (LETM) but brain MRI was normal. Serum antiaquaporin 4 antibody in the cell-based assay was positive. Serum thyroid stimulating hormone was very low with high free T4 and positive thyroid stimulating hormone receptor antibody and anti-thyroid peroxidase Ab. With optic neuritis, transverse myelitis (LETM), and positive antiaquaporin 4 antibody, he was diagnosed with NMO with Graves’ disease. Autoimmune thyroid diseases are associated with NMO in many studies but precise clinical and serological quantification of thyroid disorders especially Graves’ disease is still lacking. We are presenting a case of NMO with Graves’ disease who presented with symptoms of hyperthyroidism before myelitis. Our patient developed myelitis almost 3 years after having optic neuritis, but before myelitis, he was having symptoms of hyperthyroidism. Hence, patients of suspected NMO must be monitored for other nonneurological autoimmune diseases both clinically and serologically even in early stage when they are not fulfilling the diagnostic criteria.
{"title":"A case of NMO presenting with hyperthyroidism","authors":"Yukti Bansal, A. Patra, B. Kalita","doi":"10.4103/ajoim.ajoim_6_23","DOIUrl":"https://doi.org/10.4103/ajoim.ajoim_6_23","url":null,"abstract":"Neuromyelitis optica (NMO) is an autoimmune disease of central nervous system with extensive clinical presentations but based on the international consensus diagnostic criteria 2015. The horizon has broadened to a larger entity called NMOSD or NMO spectrum disorders. Nonneurological systemic autoimmune diseases especially thyroid disorders are commonly associated with NMOSD, among which Hashimoto’s thyroiditis is common, whereas not much literature is available regarding the association of Graves’ disease with NMOSD. A 38-year-old male presented with acute onset upper motor neuron quadriparesis along with features of hyperthyroidism with a prior history of sudden onset bilateral decreased vision of both eyes 3 years back. Magnetic resonance imaging (MRI) showed T2 hyperintensity involving cervicodorsal cord from C4 to D6 indicating a longitudinally extensive transverse myelitis (LETM) but brain MRI was normal. Serum antiaquaporin 4 antibody in the cell-based assay was positive. Serum thyroid stimulating hormone was very low with high free T4 and positive thyroid stimulating hormone receptor antibody and anti-thyroid peroxidase Ab. With optic neuritis, transverse myelitis (LETM), and positive antiaquaporin 4 antibody, he was diagnosed with NMO with Graves’ disease. Autoimmune thyroid diseases are associated with NMO in many studies but precise clinical and serological quantification of thyroid disorders especially Graves’ disease is still lacking. We are presenting a case of NMO with Graves’ disease who presented with symptoms of hyperthyroidism before myelitis. Our patient developed myelitis almost 3 years after having optic neuritis, but before myelitis, he was having symptoms of hyperthyroidism. Hence, patients of suspected NMO must be monitored for other nonneurological autoimmune diseases both clinically and serologically even in early stage when they are not fulfilling the diagnostic criteria.","PeriodicalId":426816,"journal":{"name":"Assam Journal of Internal Medicine","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127170632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajoim.ajoim_7_23
S. Shrivastava, P. Shrivastava
Lead is a toxic metal being employed in numerous industries across the world, and is responsible for environmental contamination and multiple adverse health effects during its processing, use, and disposal. The good thing is that all such effects are avoidable, but we are falling short in all possible dimensions. Even though various potential sources of exposure have been identified for environmental contamination or human adverse effects, lead paint is one of the most important ones. From a financial perspective, the use of these paints is associated with both direct and indirect economic costs and is immense in developing nations. Moreover, some nations have already adopted measures to reduce exposure to lead paint, but their practical implementation is lagging in most places. To conclude, lead exposure during childhood has been associated with multiple acute and chronic side effects. It is high time that international stakeholders realize the concern and prioritize it to reduce its level in the environment.
{"title":"Minimizing lead exposure among children: Global appeal","authors":"S. Shrivastava, P. Shrivastava","doi":"10.4103/ajoim.ajoim_7_23","DOIUrl":"https://doi.org/10.4103/ajoim.ajoim_7_23","url":null,"abstract":"Lead is a toxic metal being employed in numerous industries across the world, and is responsible for environmental contamination and multiple adverse health effects during its processing, use, and disposal. The good thing is that all such effects are avoidable, but we are falling short in all possible dimensions. Even though various potential sources of exposure have been identified for environmental contamination or human adverse effects, lead paint is one of the most important ones. From a financial perspective, the use of these paints is associated with both direct and indirect economic costs and is immense in developing nations. Moreover, some nations have already adopted measures to reduce exposure to lead paint, but their practical implementation is lagging in most places. To conclude, lead exposure during childhood has been associated with multiple acute and chronic side effects. It is high time that international stakeholders realize the concern and prioritize it to reduce its level in the environment.","PeriodicalId":426816,"journal":{"name":"Assam Journal of Internal Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114236855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Smoking is harmful and causes various diseases due to the accumulation of free radicals causing oxidative damage. Antioxidants help in resisting damage from oxidative stress resulting from cigarette smoking. The presence of the double bonds in the uric acid makes it a powerful antioxidant. Uric acid measurement is cheap, and hence, it can be used as a periodical screening tool for ensuring the adequate antioxidant activity. Objectives: To study the relationship between serum uric acid level and smoking in chronic smokers. Materials and Methods: This is a cross-sectional study among 110 smokers of age group between 28 and 60 years. A complete detailed history was obtained from subjects including age, sex, average number of daily cigarettes smoked, duration of smoking, and dietary habit. After examination, the attained subjects’ serum uric acid level were assessed. Results: Average number of cigarettes smoked (cigarettes/day) and Pack years of smoking have a significantly negative correlation with serum uric acid (mg/dL) and are not correlated with the duration of the smoking. The correlation of serum uric acid with the Pack years of smoking was significant within the age groups and with different dietary patterns, and not with the gender. Linear regression model predicts that serum uric acid (mg/dL) decreases −0.09 times for each unit increase in Pack years of smoking and is statistically significant. Conclusion: Cessation of smoking can be recommended among the smokers, to maintain the normal serum uric acid, as uric acid is responsible for the major antioxidant activity in the body, to prevent cancers.
{"title":"A cross-sectional study of association between serum uric acid levels and smoking in chronic smokers in a tertiary care hospital","authors":"Shebin Mohamed, Kinathankaraiyan Nagarajan, Sindhya Sindhukumar","doi":"10.4103/ajoim.ajoim_3_23","DOIUrl":"https://doi.org/10.4103/ajoim.ajoim_3_23","url":null,"abstract":"Background: Smoking is harmful and causes various diseases due to the accumulation of free radicals causing oxidative damage. Antioxidants help in resisting damage from oxidative stress resulting from cigarette smoking. The presence of the double bonds in the uric acid makes it a powerful antioxidant. Uric acid measurement is cheap, and hence, it can be used as a periodical screening tool for ensuring the adequate antioxidant activity. Objectives: To study the relationship between serum uric acid level and smoking in chronic smokers. Materials and Methods: This is a cross-sectional study among 110 smokers of age group between 28 and 60 years. A complete detailed history was obtained from subjects including age, sex, average number of daily cigarettes smoked, duration of smoking, and dietary habit. After examination, the attained subjects’ serum uric acid level were assessed. Results: Average number of cigarettes smoked (cigarettes/day) and Pack years of smoking have a significantly negative correlation with serum uric acid (mg/dL) and are not correlated with the duration of the smoking. The correlation of serum uric acid with the Pack years of smoking was significant within the age groups and with different dietary patterns, and not with the gender. Linear regression model predicts that serum uric acid (mg/dL) decreases −0.09 times for each unit increase in Pack years of smoking and is statistically significant. Conclusion: Cessation of smoking can be recommended among the smokers, to maintain the normal serum uric acid, as uric acid is responsible for the major antioxidant activity in the body, to prevent cancers.","PeriodicalId":426816,"journal":{"name":"Assam Journal of Internal Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116307077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Diabetes and thyroid dysfunctions are closely related to endocrine disorders. Research has shown that there is a clear connection between hyperinsulinemia, insulin resistance, increased glycated haemoglobin (HbA1c) levels, and abnormal thyroid function. Hypothyroidism is relatively common in diabetic patients, particularly in those with suboptimal glycemic control. As a result, screening for thyroid dysfunction in diabetic patients can aid in the early identification and treatment of hypothyroidism, potentially reducing the risk of complications associated with the condition. Objectives: Correlation of TSH and HbA1c in diabetic patients. Materials and Methods: This hospital-based cross-sectional study was conducted in the Department of Medicine, Assam Medical College, Dibrugarh, between February 2022 and February 2023. A total of 120 patients with diabetes attending the department without any prior history of thyroid disease or any factor that may affect thyroid function were included in this study. Thyroid-stimulating hormone (TSH) and HbA1c were done in all subjects. Results: The result showed that the mean age was 57.68 years with female preponderance (58.33%) and increased mean levels of HbA1c (7.8850%) and TSH (13.566 micro IU/mL). In our study, the mean serum TSH level was significantly higher in uncontrolled diabetes than that in controlled diabetes patients. HbA1c also showed a positive correlation (r = 0.574; P < 0.001) with thyroid abnormality. Conclusions: Conducting thyroid function screenings on diabetic patients can aid in the identification of asymptomatic hypothyroid patients. Early detection of underlying thyroid dysfunction facilitates timely treatment, which may enhance glycemic control and ultimately improve the quality of life for diabetic patients.
{"title":"A study of thyroid-stimulating hormone in patients with type 2 diabetes mellitus","authors":"Sofiur Rahman, Rajesh Dhanowar, Aritra Saha, Dipankar Das, Jinku Ozah","doi":"10.4103/ajoim.ajoim_12_23","DOIUrl":"https://doi.org/10.4103/ajoim.ajoim_12_23","url":null,"abstract":"Background: Diabetes and thyroid dysfunctions are closely related to endocrine disorders. Research has shown that there is a clear connection between hyperinsulinemia, insulin resistance, increased glycated haemoglobin (HbA1c) levels, and abnormal thyroid function. Hypothyroidism is relatively common in diabetic patients, particularly in those with suboptimal glycemic control. As a result, screening for thyroid dysfunction in diabetic patients can aid in the early identification and treatment of hypothyroidism, potentially reducing the risk of complications associated with the condition. Objectives: Correlation of TSH and HbA1c in diabetic patients. Materials and Methods: This hospital-based cross-sectional study was conducted in the Department of Medicine, Assam Medical College, Dibrugarh, between February 2022 and February 2023. A total of 120 patients with diabetes attending the department without any prior history of thyroid disease or any factor that may affect thyroid function were included in this study. Thyroid-stimulating hormone (TSH) and HbA1c were done in all subjects. Results: The result showed that the mean age was 57.68 years with female preponderance (58.33%) and increased mean levels of HbA1c (7.8850%) and TSH (13.566 micro IU/mL). In our study, the mean serum TSH level was significantly higher in uncontrolled diabetes than that in controlled diabetes patients. HbA1c also showed a positive correlation (r = 0.574; P < 0.001) with thyroid abnormality. Conclusions: Conducting thyroid function screenings on diabetic patients can aid in the identification of asymptomatic hypothyroid patients. Early detection of underlying thyroid dysfunction facilitates timely treatment, which may enhance glycemic control and ultimately improve the quality of life for diabetic patients.","PeriodicalId":426816,"journal":{"name":"Assam Journal of Internal Medicine","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121605747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajoim.ajoim_15_22
S. Yasri, V. Wiwanitkit, R. Mungmunpuntipantip
{"title":"Monkey pox and hydrocephalus","authors":"S. Yasri, V. Wiwanitkit, R. Mungmunpuntipantip","doi":"10.4103/ajoim.ajoim_15_22","DOIUrl":"https://doi.org/10.4103/ajoim.ajoim_15_22","url":null,"abstract":"","PeriodicalId":426816,"journal":{"name":"Assam Journal of Internal Medicine","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126435755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajoim.ajoim_8_23
A. Agarwal, D. Agarwal, Manoj Deori
Platelet satellitism is a rare in vitro phenomenon presenting with platelets rosetting around neutrophils observed in peripheral blood smears prepared from blood samples anticoagulated with ethylenediaminetetraacetic acid (EDTA) but not with heparin sample. The subject was a 65-year-old woman presenting with pain abdomen at our hospital. As a routine investigation, complete blood count (CBC) was advised, and collection was done in EDTA vial. The sample was run in Sysmex Xs800i five-part hematology cell counter. The results of CBC were as follows: total leucocyte count: 15.59 × 103/uL; red blood cell count: 4.61 × 106/uL; hemoglobin: 12.8 g/dL; packed cell volume: 39.5%; mean corpuscular volume: 85.7fl; mean corpuscular hemoglobin (MCH): 27.8 pg; MCH concentration: 32.4 g/dL; and platelet: 26 × 103/uL. On preparation of blood smear and after staining with Leishman stain, the smear showed the formation of platelet rosette around the neutrophils. Platelet satellitism is, hence, defined as the formation of platelet rosetting or clumping around the neutrophils in sample collected in EDTA. Microscopic examination of samples collected in EDTA vial is important before commenting on platelet count.
{"title":"Platelet satellitism: Ethylenediaminetetraacetic acid sample versus heparin sample","authors":"A. Agarwal, D. Agarwal, Manoj Deori","doi":"10.4103/ajoim.ajoim_8_23","DOIUrl":"https://doi.org/10.4103/ajoim.ajoim_8_23","url":null,"abstract":"Platelet satellitism is a rare in vitro phenomenon presenting with platelets rosetting around neutrophils observed in peripheral blood smears prepared from blood samples anticoagulated with ethylenediaminetetraacetic acid (EDTA) but not with heparin sample. The subject was a 65-year-old woman presenting with pain abdomen at our hospital. As a routine investigation, complete blood count (CBC) was advised, and collection was done in EDTA vial. The sample was run in Sysmex Xs800i five-part hematology cell counter. The results of CBC were as follows: total leucocyte count: 15.59 × 103/uL; red blood cell count: 4.61 × 106/uL; hemoglobin: 12.8 g/dL; packed cell volume: 39.5%; mean corpuscular volume: 85.7fl; mean corpuscular hemoglobin (MCH): 27.8 pg; MCH concentration: 32.4 g/dL; and platelet: 26 × 103/uL. On preparation of blood smear and after staining with Leishman stain, the smear showed the formation of platelet rosette around the neutrophils. Platelet satellitism is, hence, defined as the formation of platelet rosetting or clumping around the neutrophils in sample collected in EDTA. Microscopic examination of samples collected in EDTA vial is important before commenting on platelet count.","PeriodicalId":426816,"journal":{"name":"Assam Journal of Internal Medicine","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124338378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajoim.ajoim_25_22
Parimi Shashank, Intikabur Rahman
Essential thrombocytosis is a chronic myeloproliferative disorder of unknown etiology, which is characterized by persistent megakaryocytic proliferation, resulting in markedly increased platelets in circulation. We present the case of a 40-year-old female patient, who came with complaints of excessive tiredness, infrequent tingling sensation at the tip of her fingers, and generalized body ache, and was initially detected to have extreme thrombocytosis of 1,775,000/mm3. On further evaluation, she was diagnosed with essential thrombocytosis and did not report any further deterioration throughout the follow-up period and is being maintained on low-dose aspirin.
{"title":"Essential thrombocytosis: A rare entity","authors":"Parimi Shashank, Intikabur Rahman","doi":"10.4103/ajoim.ajoim_25_22","DOIUrl":"https://doi.org/10.4103/ajoim.ajoim_25_22","url":null,"abstract":"Essential thrombocytosis is a chronic myeloproliferative disorder of unknown etiology, which is characterized by persistent megakaryocytic proliferation, resulting in markedly increased platelets in circulation. We present the case of a 40-year-old female patient, who came with complaints of excessive tiredness, infrequent tingling sensation at the tip of her fingers, and generalized body ache, and was initially detected to have extreme thrombocytosis of 1,775,000/mm3. On further evaluation, she was diagnosed with essential thrombocytosis and did not report any further deterioration throughout the follow-up period and is being maintained on low-dose aspirin.","PeriodicalId":426816,"journal":{"name":"Assam Journal of Internal Medicine","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131251200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajoim.ajoim_22_22
C. Baruah, B. Baruah, S. Bhattacharjee, Karuna Hazarika
Background: Snake bite envenomation is a neglected tropical disease which needs urgent medical attention and anti-snake venom (ASV) infusion but is often overlooked and under-reported owing to the age-old tradition of local aid by quacks, poor transportation facilities, and lack of public awareness. This leads to delays in hospitalization and causes increased morbidity and mortality. WHO’s global target is to reduce the number of snake bite deaths to half by 2030 and India needs to play an important role in achieving the target. Aims and Objectives: (a) To study the clinical profile of patients, 12 years of age or above, presenting with snake bites, attending OPD and Emergency in the Department of Medicine, TMCH. (b) To study the effectiveness of ASV and adverse effects following its use. Materials and Methods: (a) Study design—hospital based cross-sectional study. (b) Duration—1st January 2020 to 30th June 2022. (c) Number of cases—221. Results: Out of 221 cases, non-venomous bites and venomous bites were 88.2% and 11.7%, respectively. Out of the venomous cases, 61.5% were hemotoxic and 38.4% were neurotoxic. A total of three patients died during our study and all of these were from neurotoxic bites. Conclusion: Snake bite is an important rural and occupational hazard. Delay in hospitalization following snake bite creates a hindrance in timely administration of ASV leading to deleterious effects which may prove fatal. In the present study neurotoxic bites proved to be more fatal in comparison to hemotoxic bites.
{"title":"A study of clinical profile of patients with snake bite attending a tertiary care hospital in the north bank of the Brahmaputra: A hospital based cross sectional study","authors":"C. Baruah, B. Baruah, S. Bhattacharjee, Karuna Hazarika","doi":"10.4103/ajoim.ajoim_22_22","DOIUrl":"https://doi.org/10.4103/ajoim.ajoim_22_22","url":null,"abstract":"Background: Snake bite envenomation is a neglected tropical disease which needs urgent medical attention and anti-snake venom (ASV) infusion but is often overlooked and under-reported owing to the age-old tradition of local aid by quacks, poor transportation facilities, and lack of public awareness. This leads to delays in hospitalization and causes increased morbidity and mortality. WHO’s global target is to reduce the number of snake bite deaths to half by 2030 and India needs to play an important role in achieving the target. Aims and Objectives: (a) To study the clinical profile of patients, 12 years of age or above, presenting with snake bites, attending OPD and Emergency in the Department of Medicine, TMCH. (b) To study the effectiveness of ASV and adverse effects following its use. Materials and Methods: (a) Study design—hospital based cross-sectional study. (b) Duration—1st January 2020 to 30th June 2022. (c) Number of cases—221. Results: Out of 221 cases, non-venomous bites and venomous bites were 88.2% and 11.7%, respectively. Out of the venomous cases, 61.5% were hemotoxic and 38.4% were neurotoxic. A total of three patients died during our study and all of these were from neurotoxic bites. Conclusion: Snake bite is an important rural and occupational hazard. Delay in hospitalization following snake bite creates a hindrance in timely administration of ASV leading to deleterious effects which may prove fatal. In the present study neurotoxic bites proved to be more fatal in comparison to hemotoxic bites.","PeriodicalId":426816,"journal":{"name":"Assam Journal of Internal Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125234735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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