Pub Date : 2022-01-29DOI: 10.3390/dermatopathology9010008
Hatice Zengin, Bahadır Yıldız, T. Pukhalskaya, B. Smoller
Background: Cutaneous mixed tumors (CMTs) include benign, atypical, and malignant chondroid syringomas. This spectrum of entities is known to be a part of myoepithelial neoplasms, which display considerable genetic heterogeneity. In a previous report, a malignant chondroid syringoma (MCS) demonstrated PHF1-TFE3 gene fusion and strong TFE3 immunohistochemical (IHC) staining. The authors suggested that the MCS is genetically related to tumors with TFE3 rearrangements such as renal cell carcinoma and might have genetic heterogeneity. In this study, we aim to investigate potential TFE3 gene fusions with TFE3 IHC stain in a spectrum of CMTs. Materials: Eleven benign chondroid syringoma (BCS), one atypical chondroid syringoma (ACS), and one malignant chondroid syringoma cases were identified, stained with TFE3 IHC stain, and interpreted based on preset criteria. Results: ACS and MCS cases did not show any staining. In 7 of 11 BCS cases, weak (1+) staining was observed in less than 20% of the tumor cells and were considered negative. Additionally, in one BCS case, weak (1+) and (2+) staining was shown in approximately 15% and less than 1% of the tumor cells, respectively. Based on our positivity criteria, this case was also interpreted as negative. Conclusions: Our study failed to reveal possible TFE3 gene fusion by IHC staining in benign, atypical, and malignant chondroid syringomas. Although the negative staining in MCS suggests a genetic heterogeneity in this entity, further studies with larger case groups are needed for a more definitive conclusion.
{"title":"Absence of TFE3 Immunoexpression in a Spectrum of Cutaneous Mixed Tumors: A Retrospective Pilot Study","authors":"Hatice Zengin, Bahadır Yıldız, T. Pukhalskaya, B. Smoller","doi":"10.3390/dermatopathology9010008","DOIUrl":"https://doi.org/10.3390/dermatopathology9010008","url":null,"abstract":"Background: Cutaneous mixed tumors (CMTs) include benign, atypical, and malignant chondroid syringomas. This spectrum of entities is known to be a part of myoepithelial neoplasms, which display considerable genetic heterogeneity. In a previous report, a malignant chondroid syringoma (MCS) demonstrated PHF1-TFE3 gene fusion and strong TFE3 immunohistochemical (IHC) staining. The authors suggested that the MCS is genetically related to tumors with TFE3 rearrangements such as renal cell carcinoma and might have genetic heterogeneity. In this study, we aim to investigate potential TFE3 gene fusions with TFE3 IHC stain in a spectrum of CMTs. Materials: Eleven benign chondroid syringoma (BCS), one atypical chondroid syringoma (ACS), and one malignant chondroid syringoma cases were identified, stained with TFE3 IHC stain, and interpreted based on preset criteria. Results: ACS and MCS cases did not show any staining. In 7 of 11 BCS cases, weak (1+) staining was observed in less than 20% of the tumor cells and were considered negative. Additionally, in one BCS case, weak (1+) and (2+) staining was shown in approximately 15% and less than 1% of the tumor cells, respectively. Based on our positivity criteria, this case was also interpreted as negative. Conclusions: Our study failed to reveal possible TFE3 gene fusion by IHC staining in benign, atypical, and malignant chondroid syringomas. Although the negative staining in MCS suggests a genetic heterogeneity in this entity, further studies with larger case groups are needed for a more definitive conclusion.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"48 - 53"},"PeriodicalIF":1.9,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47883458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-28DOI: 10.3390/dermatopathology9010007
Austin Miller, Susuana Adjei, L. Temiz, Pavandeep Gill, Alfredo Siller, S. Tyring
Poromas or poroid tumors are a group of rare, benign cutaneous neoplasms derived from the terminal eccrine or apocrine sweat gland duct. There are four poroma variants with overlapping features: dermal duct tumor (DDT), eccrine poroma, hidroacanthoma simplex, and poroid hidradenoma, of which DDT is the least common. Clinically, the variants have a nonspecific appearance and present as solitary dome-shaped papules, plaques, or nodules. They can be indistinguishable from each other and a multitude of differential diagnoses, necessitating a better understanding of the characteristics that make the diagnosis of poroid neoplasms. However, there remains a paucity of information on these lesions, especially DDTs, given their infrequent occurrence. Herein, we review the literature on DDTs with an emphasis on epidemiology, pathogenesis, clinical features, diagnosis, and management.
{"title":"Dermal Duct Tumor: A Diagnostic Dilemma","authors":"Austin Miller, Susuana Adjei, L. Temiz, Pavandeep Gill, Alfredo Siller, S. Tyring","doi":"10.3390/dermatopathology9010007","DOIUrl":"https://doi.org/10.3390/dermatopathology9010007","url":null,"abstract":"Poromas or poroid tumors are a group of rare, benign cutaneous neoplasms derived from the terminal eccrine or apocrine sweat gland duct. There are four poroma variants with overlapping features: dermal duct tumor (DDT), eccrine poroma, hidroacanthoma simplex, and poroid hidradenoma, of which DDT is the least common. Clinically, the variants have a nonspecific appearance and present as solitary dome-shaped papules, plaques, or nodules. They can be indistinguishable from each other and a multitude of differential diagnoses, necessitating a better understanding of the characteristics that make the diagnosis of poroid neoplasms. However, there remains a paucity of information on these lesions, especially DDTs, given their infrequent occurrence. Herein, we review the literature on DDTs with an emphasis on epidemiology, pathogenesis, clinical features, diagnosis, and management.","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"36 - 47"},"PeriodicalIF":1.9,"publicationDate":"2022-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47065707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-26DOI: 10.3390/dermatopathology9010006
Rigorous peer-reviews are the basis of high-quality academic publishing [...]
严谨的同行评审是高质量学术出版的基础〔…〕
{"title":"Acknowledgment to Reviewers of Dermatopathology in 2021","authors":"","doi":"10.3390/dermatopathology9010006","DOIUrl":"https://doi.org/10.3390/dermatopathology9010006","url":null,"abstract":"Rigorous peer-reviews are the basis of high-quality academic publishing [...]","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"9 1","pages":"35 - 35"},"PeriodicalIF":1.9,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46756777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-82820-2_16
W. Kempf, M. Hantschke, H. Kutzner
{"title":"Drug Reactions","authors":"W. Kempf, M. Hantschke, H. Kutzner","doi":"10.1007/978-3-030-82820-2_16","DOIUrl":"https://doi.org/10.1007/978-3-030-82820-2_16","url":null,"abstract":"","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"38 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50980353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-82820-2_1
W. Kempf, M. Hantschke, H. Kutzner
{"title":"Principles of Diagnosis","authors":"W. Kempf, M. Hantschke, H. Kutzner","doi":"10.1007/978-3-030-82820-2_1","DOIUrl":"https://doi.org/10.1007/978-3-030-82820-2_1","url":null,"abstract":"","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"158 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50980093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-82820-2_20
W. Kempf, M. Hantschke, H. Kutzner
{"title":"Epidermal Hamartomas and Neoplasms","authors":"W. Kempf, M. Hantschke, H. Kutzner","doi":"10.1007/978-3-030-82820-2_20","DOIUrl":"https://doi.org/10.1007/978-3-030-82820-2_20","url":null,"abstract":"","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"34 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50980456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-82820-2_5
W. Kempf, M. Hantschke, H. Kutzner
{"title":"Epidermis: Spongiosis, Acanthosis and Hyperparakeratosis","authors":"W. Kempf, M. Hantschke, H. Kutzner","doi":"10.1007/978-3-030-82820-2_5","DOIUrl":"https://doi.org/10.1007/978-3-030-82820-2_5","url":null,"abstract":"","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"38 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50980629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-82820-2_10
W. Kempf, M. Hantschke, H. Kutzner
{"title":"Dermis Granulomatous Inflammation","authors":"W. Kempf, M. Hantschke, H. Kutzner","doi":"10.1007/978-3-030-82820-2_10","DOIUrl":"https://doi.org/10.1007/978-3-030-82820-2_10","url":null,"abstract":"","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"6 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50980150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-030-82820-2_9
W. Kempf, M. Hantschke, H. Kutzner
{"title":"Dermis Vascular Disorders","authors":"W. Kempf, M. Hantschke, H. Kutzner","doi":"10.1007/978-3-030-82820-2_9","DOIUrl":"https://doi.org/10.1007/978-3-030-82820-2_9","url":null,"abstract":"","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"101 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50980692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1007/978-3-7985-1840-7_25
W. Kempf, M. Hantschke, H. Kutzner
{"title":"Lymphomas and Pseudolymphomas","authors":"W. Kempf, M. Hantschke, H. Kutzner","doi":"10.1007/978-3-7985-1840-7_25","DOIUrl":"https://doi.org/10.1007/978-3-7985-1840-7_25","url":null,"abstract":"","PeriodicalId":42885,"journal":{"name":"Dermatopathology","volume":"1 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51415931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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