Irene Solana López, Juan Antonio Guerra Martínez, D. Malón Giménez, L. Rodríguez Lajusticia, Carmen Pantín González, Ana Manuela Martín Fernández de Soignie, C. De Zea Luque, Beatriz Losada Vila, Nadia Sánchez Baños, Fátima Escalona Martín, Elia Martínez Moreno, D. Gutiérrez Abad, I. Juez Martel, B. Jiménez Munarríz, J. Calzas Rodríguez
{"title":"News and updates in the treatment of localized stage triple-negative breast cancer","authors":"Irene Solana López, Juan Antonio Guerra Martínez, D. Malón Giménez, L. Rodríguez Lajusticia, Carmen Pantín González, Ana Manuela Martín Fernández de Soignie, C. De Zea Luque, Beatriz Losada Vila, Nadia Sánchez Baños, Fátima Escalona Martín, Elia Martínez Moreno, D. Gutiérrez Abad, I. Juez Martel, B. Jiménez Munarríz, J. Calzas Rodríguez","doi":"10.5603/ocp.2023.0026","DOIUrl":"https://doi.org/10.5603/ocp.2023.0026","url":null,"abstract":"","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89739372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam Fałkowski, Aleksandra Żołnierek, J. Zolnierek
{"title":"Spectacular clinical benefit achieved by multidisciplinary management of a kidney cancer patient","authors":"Adam Fałkowski, Aleksandra Żołnierek, J. Zolnierek","doi":"10.5603/ocp.2023.0037","DOIUrl":"https://doi.org/10.5603/ocp.2023.0037","url":null,"abstract":"","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85152870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Barbara Radecka, M. Gełej, Monika Kotyla, Tomasz Kubiatowski
Progress in understanding complex interactions between cancer cells and the immune system has led to the development of new methods of treatment — immunotherapy, modulating the anti-cancer response of the immune system. For several years, colorectal cancer (CRC) was thought to be a cancer with low immune stimulation potential, but in recent years the favorable prognostic value of lymphocytic infiltrates in the tumor has been noted. Currently it is well known that the stimulation of the immune system by CRC cells is associated with the accumulation of mutations in DNA microsatellites. This phenomenon results from impairment of function of genes (mainly MLH1, MSH2, MSH6 and PMS2) encoding proteins involved in correction of mismatched nucleotides during replication (dMMR), whose phenotypic reflection is microsatellite instability (MSI). It affects about 15–20% of CRC, with clear differences depending on the stage of cancer — about 20% in stage II, 12% in stage III, and only around 4% in stage IV. dMMR/MSI cancers are highly immunogenic through overexpression of tumor antigens and can induce a deep immune response. Cancers with intact repair gene system (pMMR) and stable microsatellites (MSS) show poor immunogenicity, which makes it difficult to induce an anti-tumor immune response. The relationship between impairment of the mismatch repair system and the induction of an anti-cancer immune response justifies the use of checkpoint inhibitors of this response in the treatment of patients with CRC MSI/dMMR. In MSS/pMMR cancers, checkpoint inhibitors used in monotherapy are not effective. However, studies are underway to combine these drugs with other methods of systemic treatment (chemotherapy, EGFR inhibitors, angiogenesis inhibitors, MET inhibitors), as well as radiotherapy.
{"title":"Immunotherapy for colorectal cancer","authors":"Barbara Radecka, M. Gełej, Monika Kotyla, Tomasz Kubiatowski","doi":"10.5603/ocp.2023.0027","DOIUrl":"https://doi.org/10.5603/ocp.2023.0027","url":null,"abstract":"Progress in understanding complex interactions between cancer cells and the immune system has led to the development of new methods of treatment — immunotherapy, modulating the anti-cancer response of the immune system. For several years, colorectal cancer (CRC) was thought to be a cancer with low immune stimulation potential, but in recent years the favorable prognostic value of lymphocytic infiltrates in the tumor has been noted. Currently it is well known that the stimulation of the immune system by CRC cells is associated with the accumulation of mutations in DNA microsatellites. This phenomenon results from impairment of function of genes (mainly MLH1, MSH2, MSH6 and PMS2) encoding proteins involved in correction of mismatched nucleotides during replication (dMMR), whose phenotypic reflection is microsatellite instability (MSI). It affects about 15–20% of CRC, with clear differences depending on the stage of cancer — about 20% in stage II, 12% in stage III, and only around 4% in stage IV. dMMR/MSI cancers are highly immunogenic through overexpression of tumor antigens and can induce a deep immune response. Cancers with intact repair gene system (pMMR) and stable microsatellites (MSS) show poor immunogenicity, which makes it difficult to induce an anti-tumor immune response. The relationship between impairment of the mismatch repair system and the induction of an anti-cancer immune response justifies the use of checkpoint inhibitors of this response in the treatment of patients with CRC MSI/dMMR. In MSS/pMMR cancers, checkpoint inhibitors used in monotherapy are not effective. However, studies are underway to combine these drugs with other methods of systemic treatment (chemotherapy, EGFR inhibitors, angiogenesis inhibitors, MET inhibitors), as well as radiotherapy.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75507042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this article, we discuss benign and malignant spermatic cord tumors. We attempted to compile this rare group of diseases by reviewing the international literature. Tumors of the spermatic cord are found very rarely. However, it is important to be aware of their occurrence, as they can cause a protrusion in the inguinal area. They are usually misdiagnosed as an inguinal hernia. The most common tumors in this area are benign — usually they are lipomas. In 20–70% of cases, adipose tumors accompany an inguinal hernia. Therefore, they should be kept in mind whenever a patient presents with symptoms of herniation in the inguinal region. Tumors of the spermatic cord may also involve the scrotum and manifest themselves as testicular hydrocele. Such a tumor is, for example, aggressive angiomyxoma. It is a locally malignant tumor that tends to infiltrate and compress the surrounding tissues but does not tend to give metastasis, therefore according to the WHO classification it is a benign tumor. However, malignant tumors such as rhabdomyosarcoma, which is the most common malignant neoplasm of testicular appendages, can also be located in the spermatic cord. The second most common soft tissue sarcoma is leiomyosarcoma, with poor initial prognosis, or metastases of malignant tumors from other organs, e.g. renal adenocarcinoma. As the prognosis for malignant tumors of the spermatic cord is generally dependent on the stage at the time of diagnosis, oncological vigilance and early diagnosis allow for faster detection of these tumors, which may improve the prognosis of patients with tumors in this location.
{"title":"Spermatic cord tumors — review of the literature","authors":"Krzysztof Kowalik, A. Modrzejewski, Adam Kurpik","doi":"10.5603/ocp.2023.0015","DOIUrl":"https://doi.org/10.5603/ocp.2023.0015","url":null,"abstract":"In this article, we discuss benign and malignant spermatic cord tumors. We attempted to compile this rare group of diseases by reviewing the international literature. Tumors of the spermatic cord are found very rarely. However, it is important to be aware of their occurrence, as they can cause a protrusion in the inguinal area. They are usually misdiagnosed as an inguinal hernia. The most common tumors in this area are benign — usually they are lipomas. In 20–70% of cases, adipose tumors accompany an inguinal hernia. Therefore, they should be kept in mind whenever a patient presents with symptoms of herniation in the inguinal region. Tumors of the spermatic cord may also involve the scrotum and manifest themselves as testicular hydrocele. Such a tumor is, for example, aggressive angiomyxoma. It is a locally malignant tumor that tends to infiltrate and compress the surrounding tissues but does not tend to give metastasis, therefore according to the WHO classification it is a benign tumor. However, malignant tumors such as rhabdomyosarcoma, which is the most common malignant neoplasm of testicular appendages, can also be located in the spermatic cord. The second most common soft tissue sarcoma is leiomyosarcoma, with poor initial prognosis, or metastases of malignant tumors from other organs, e.g. renal adenocarcinoma. As the prognosis for malignant tumors of the spermatic cord is generally dependent on the stage at the time of diagnosis, oncological vigilance and early diagnosis allow for faster detection of these tumors, which may improve the prognosis of patients with tumors in this location.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72454304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Gełej, B. Radecka, Monika Kotyla, Weronika Radecka, T. Kubiatowski
{"title":"Immunotherapy for gastroesophageal cancer","authors":"M. Gełej, B. Radecka, Monika Kotyla, Weronika Radecka, T. Kubiatowski","doi":"10.5603/ocp.2023.0028","DOIUrl":"https://doi.org/10.5603/ocp.2023.0028","url":null,"abstract":"","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86927284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Magdalena Sakowicz, B. Jagielska, L. Bodnar, Janusz Jaroszyński, Maciej Krzakowski
{"title":"Implementation of the Polish version of the 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11): importance for oncology","authors":"Magdalena Sakowicz, B. Jagielska, L. Bodnar, Janusz Jaroszyński, Maciej Krzakowski","doi":"10.5603/ocp.2023.0032","DOIUrl":"https://doi.org/10.5603/ocp.2023.0032","url":null,"abstract":"","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81570260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sajad Hamidi, N. Seyedfatemi, M. Mardani-Hamooleh, Z. Abbasi, H. Hamidi
{"title":"The effect of spirituality-based education on the meaning of life in cancer patients: a quasi-experimental study","authors":"Sajad Hamidi, N. Seyedfatemi, M. Mardani-Hamooleh, Z. Abbasi, H. Hamidi","doi":"10.5603/ocp.2023.0034","DOIUrl":"https://doi.org/10.5603/ocp.2023.0034","url":null,"abstract":"","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80714428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jakub Pytlos, J. Pałucki, M. Lenarcik, Ireneusz Pierzankowski, A. Klimczak, T. Olesiński
In this case series we present the cases of two patients at a metastatic stage of stomach gastrointestinal stromal tumor, who received treatment with imatinib. After a period of disease stability patients showed signs of resistance to the first-line therapy and despite the promising switch to sunitinib, developed life-threatening complications. Salvage surgeries were performed, aimed at preserving patients life and simultaneously reducing the tumor mass. Operation greatly improved patients condition and allowed for successful continuation of tyrosine kinase inhibitor treatment, showing that surgery should be considered a viable complement to the chemotherapeutical treatment.
{"title":"Individualized surgical treatment in patients with advanced gastrointestinal stromal tumor — a case series","authors":"Jakub Pytlos, J. Pałucki, M. Lenarcik, Ireneusz Pierzankowski, A. Klimczak, T. Olesiński","doi":"10.5603/ocp.2023.0023","DOIUrl":"https://doi.org/10.5603/ocp.2023.0023","url":null,"abstract":"In this case series we present the cases of two patients at a metastatic stage of stomach gastrointestinal stromal tumor, who received treatment with imatinib. After a period of disease stability patients showed signs of resistance to the first-line therapy and despite the promising switch to sunitinib, developed life-threatening complications. Salvage surgeries were performed, aimed at preserving patients life and simultaneously reducing the tumor mass. Operation greatly improved patients condition and allowed for successful continuation of tyrosine kinase inhibitor treatment, showing that surgery should be considered a viable complement to the chemotherapeutical treatment.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80452785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Kocańda, Michał Chrobot, M. Samardakiewicz, M. Jabłoński
Introduction. The profession of psycho-oncologist in Poland is not sufficiently regulated by law. Current solutions in the system involve contradictory regulations on obtaining qualifications to practice, which produces in effect systemic chaos and result in limited availability of services provided to oncology patients and their families by practitioners of this demanding profession. Material and methods. A survey conducted among psycho-oncologists concerning their professional identity was used in order to examine their opinion on the current legal regulations of this profession and the possible consequences of incoherent law solutions. The study used an original anonymous questionnaire entitled Survey on selected aspects of the psycho-oncology profession in the context of its scope and method of legal regulation and the Job Satisfaction Scale questionnaire. Results. The study showed that the inconsistency in legal regulations may result in restricted access to this profession, indicated doubts concerning the legal credentials required to use the professional title of psycho-oncologist and the lack of symmetry in individual competencies of practitioners with different underlying profession. Conclusions. The research confirmed the organizational chaos which negatively affects the way psycho -on- cologists practice their profession. As a consequence the legislator intervention is required in order to modify the legal regulation of this profession.
{"title":"Opinion of representatives of the psycho-oncology community on the lack of coherent systemic solutions on the legal regulation of their profession","authors":"K. Kocańda, Michał Chrobot, M. Samardakiewicz, M. Jabłoński","doi":"10.5603/ocp.2023.0031","DOIUrl":"https://doi.org/10.5603/ocp.2023.0031","url":null,"abstract":"Introduction. The profession of psycho-oncologist in Poland is not sufficiently regulated by law. Current solutions in the system involve contradictory regulations on obtaining qualifications to practice, which produces in effect systemic chaos and result in limited availability of services provided to oncology patients and their families by practitioners of this demanding profession. Material and methods. A survey conducted among psycho-oncologists concerning their professional identity was used in order to examine their opinion on the current legal regulations of this profession and the possible consequences of incoherent law solutions. The study used an original anonymous questionnaire entitled Survey on selected aspects of the psycho-oncology profession in the context of its scope and method of legal regulation and the Job Satisfaction Scale questionnaire. Results. The study showed that the inconsistency in legal regulations may result in restricted access to this profession, indicated doubts concerning the legal credentials required to use the professional title of psycho-oncologist and the lack of symmetry in individual competencies of practitioners with different underlying profession. Conclusions. The research confirmed the organizational chaos which negatively affects the way psycho -on- cologists practice their profession. As a consequence the legislator intervention is required in order to modify the legal regulation of this profession.","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78275445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renata Langford, Maciej Krzakowski, D. Kowalski, Rafał Krenke, T. Orłowski, Witold Rzyman, Bartosz Wasąg
{"title":"STANOWISKO EKSPERTÓW DOTYCZĄCE LECZENIA UZUPEŁNIAJĄCEGO OZYMERTYNIBEM CHORYCH NA NIEDROBNOKOMÓRKOWEGO RAKA PŁUCA PO RADYKALNEJ RESEKCJI NOWOTWORU","authors":"Renata Langford, Maciej Krzakowski, D. Kowalski, Rafał Krenke, T. Orłowski, Witold Rzyman, Bartosz Wasąg","doi":"10.5603/ocp.2023.0018","DOIUrl":"https://doi.org/10.5603/ocp.2023.0018","url":null,"abstract":"","PeriodicalId":42942,"journal":{"name":"Oncology in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76253460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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