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Non-cancer febrile neutropenia in children: pathogens, antimicrobial susceptibilities, and outcomes 儿童非癌症发热性中性粒细胞减少症:病原体、抗菌药敏感性和预后
IF 0.8 Pub Date : 2024-06-07 DOI: 10.1186/s43054-024-00276-0
Radwa Abdel-Raheem Radwan, Ilham Youssry, R. A. A. Afifi, Afaf Mohamed Samy El Banna, Mariam Mahmoud Mohammed Balah, Eman Abdel El Raouf Mohammed
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引用次数: 0
A case of intermittent bilious emesis in a term neonate: a case report and brief review of literature 一例足月新生儿间歇性胆汁淤积症:病例报告和文献综述
IF 0.8 Pub Date : 2024-06-03 DOI: 10.1186/s43054-024-00274-2
Asha Mudugere, Antaryami Pradhan, Vijay Kumar, Debasish Nanda
Neonatal intestinal obstruction is a complex condition that poses challenge in management. Prompt recognition and appropriate management are crucial to prevent complications. We present a case of a term neonate with intermittent bilious vomiting. The baby underwent routinely performed investigations, including abdominal radiography and ultrasound, which provided inconclusive results. However, contrast-enhanced computed tomography revealed a web at duodenojejunal flexure. Exploratory laparotomy confirmed the diagnosis, and surgical intervention was performed. The baby’s postoperative course was prolonged with a gradual transition from parenteral nutrition to enteral feeds. This case highlights a rare cause of intestinal obstruction, the unusual location of duodenal web, the importance of maintaining a high index of suspicion for intestinal obstruction, even in the absence of classical signs, and the value of utilizing contrast-enhanced computed tomography when initial investigations are inconclusive.
新生儿肠梗阻是一种复杂的疾病,给治疗带来了挑战。及时识别和适当处理对预防并发症至关重要。我们介绍了一例患有间歇性胆汁性呕吐的足月新生儿。患儿接受了常规检查,包括腹部放射线检查和超声波检查,但均未得出结论。然而,造影剂增强计算机断层扫描发现十二指肠空肠挠曲处有一个网状物。剖腹探查术证实了诊断,并进行了手术治疗。婴儿术后病程延长,逐渐从肠外营养过渡到肠内喂养。本病例强调了肠梗阻的罕见病因、十二指肠蹼的不寻常位置、即使没有典型体征也要高度怀疑肠梗阻的重要性,以及在初步检查结果不确定时使用造影剂增强计算机断层扫描的价值。
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引用次数: 0
Recurrent hyponatremia in neonate: a case of renal salt wasting syndrome 新生儿反复低钠血症:肾性盐耗损综合征病例
IF 0.8 Pub Date : 2024-05-31 DOI: 10.1186/s43054-024-00275-1
Innama Maryam, Rufaida Mazahir, Afreen Khanam, Uzma Firdaus, Syed Manazir Ali
Renal salt wasting (RSW) is primarily seen with central nervous disorders and is characterized by hyponatremia, elevated urinary sodium excretion, increased urine output, and hypovolemia. Although there have been reports of RSW in children, it has not been reported in newborns. A term (38 weeks 2 days) female weighing 2060 g, born via normal vaginal delivery, to a primi-gravida mother, was admitted to our neonatal intensive care unit. At birth, the baby was non-vigorous, had aspirated meconium, and required bag-and-mask ventilation following which the baby cried. The child was put on CPAP and inotropes for respiratory distress and shock, respectively, along with first-line antibiotics. Over the next few days, the child was weaned off CPAP, inotropes were stopped, and feeds were started. On postnatal day (PND) 8, the baby developed repeated episodes of seizures requiring two-antiepileptics followed by midazolam infusion, had shock requiring inotropes, and also had a tense anterior fontanelle with altered sensorium and tone changes, for which mannitol and 3% saline were given. Antibiotics were upgraded, and neuroimaging (MRI) revealed left basal-ganglia bleed with intraventricular extension and cerebral venous thrombosis. The baby showed gradual clinical improvement with the above measures and was restarted on feeds. However, from PND-19 onwards the baby had repeated episodes of hyponatremia requiring 3% saline infusions, progressive weight loss, and polyuria. Considering RSW, urine sodium was done which was high (110 mmol/L). For polyuria and weight loss, feed volume was increased, whereas, for hyponatremia, table salt was added to the expressed breast milk (1 gm × tds). Subsequently, all the serum sodium values remained within normal limits, and the baby started gaining weight and was discharged on similar advice (PND 38). On further follow-up, table salt was gradually decreased in the feeds and was stopped after 1 month of discharge with normal serum sodium values. Management of recurrent hyponatremia in a neonate is challenging. Despite its rarity, RSW in newborns should be considered a differential.
肾盐耗竭(RSW)主要见于中枢神经紊乱,其特征是低钠血症、尿钠排泄增加、尿量增加和低血容量。虽然有关于儿童 RSW 的报道,但还没有关于新生儿 RSW 的报道。我们的新生儿重症监护室收治了一名经阴道正常分娩的足月(38 周 2 天)女婴,体重 2060 克,母亲为初产妇。刚出生时,婴儿没有活力,吸入了胎粪,需要进行袋面罩通气,之后婴儿哭闹不止。患儿因呼吸窘迫和休克分别接受了 CPAP 和肌注,并使用了一线抗生素。在接下来的几天里,婴儿逐渐脱离了心肺复苏术,停止了肌注,并开始进食。出生后第 8 天,婴儿反复出现癫痫发作,需要服用两种抗癫痫药,然后输注咪达唑仑,并出现休克,需要肌注营养剂,而且前囟门紧张,感觉改变,张力改变,需要服用甘露醇和 3% 生理盐水。抗生素升级后,神经影像学(MRI)显示左侧基底神经节出血并伴有脑室内扩展和脑静脉血栓形成。采取上述措施后,婴儿的临床症状逐渐好转,并重新开始喂养。然而,从 PND-19 开始,婴儿反复出现低钠血症,需要输注 3% 的生理盐水,体重逐渐下降,并出现多尿。考虑到 RSW,进行了尿钠检测,结果显示尿钠偏高(110 毫摩尔/升)。针对多尿和体重减轻,增加了喂食量,而针对低钠血症,在挤出的母乳中添加了食盐(1 克×tds)。随后,所有血清钠值均保持在正常范围内,婴儿体重开始增加,并在类似建议下出院(PND 38)。在进一步的随访中,喂食中的食盐逐渐减少,出院 1 个月后停止喂食,血清钠值正常。处理新生儿复发性低钠血症具有挑战性。尽管新生儿 RSW 很罕见,但仍应将其作为一种鉴别诊断。
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引用次数: 0
Plasma exchange is the hope for critically ill children with life-threatening autoimmune hemolytic anemia 血浆置换是患有危及生命的自身免疫性溶血性贫血的重症儿童的希望所在
IF 0.8 Pub Date : 2024-05-29 DOI: 10.1186/s43054-024-00270-6
Noha El-Anwar, Hafez Bazaraa, Fatma Abdel Maksoud, Yasmin Ramadan
Autoimmune hemolytic anemia (AIHA) is a rare disease in children, sometimes associated with acute, life-threatening, rapidly progressive course requiring prompt management. The aim of our study is to describe the role and outcome of plasma exchange in the acute management of pediatric patients with AIHA requiring transfusion and refractory to high doses of corticosteroids. This was a descriptive retrospective report of all patients admitted to the pediatric intensive care unit (PICU) of Children’s University Hospital who received PE for acute intractable AIHA resistant to management with pulse steroids starting from June 2017 to June 2022. The demographic data, vitals, and laboratory investigations at PICU admission and upon discharge were gathered. The number of PE sessions needed for each patient, volume used for exchange, type of replacement, IV access used, complications, and outcome were reported. This series included 19 patients, 10 males, and 9 females, with a median age and weight of 76 months (IQR 18–121), and 20.9 kg. Improvement of the mean hemoglobin was observed from 5.3 ± 1.8 to 9.9 ± 2.6 g/dl at discharge. The average number of PE sessions was 2.4 sessions with no adverse effects encountered. The mean PICU stay was 16.6 days. Mortality occurred in 2 patients (10.5%) due to their primary illness, while 7 patients (36.8%) were in need of further immunotherapy, and 5 patients (28%) showed relapse. PE may be used as a safe and successful therapy in children with severe acute life-threatening AIHA not responding to steroids, or if well-matched PRBCs are unavailable for transfusion.
自身免疫性溶血性贫血(AIHA)是一种罕见的儿童疾病,有时会出现急性、危及生命、进展迅速的病程,需要及时治疗。我们的研究旨在描述血浆置换在急性期治疗需要输血且大剂量皮质类固醇治疗无效的自身免疫性溶血性贫血儿科患者中的作用和结果。这是一份描述性回顾性报告,涉及儿童大学医院儿科重症监护室(PICU)自2017年6月至2022年6月期间收治的所有因脉冲类固醇治疗耐药的急性难治性AIHA而接受血浆置换的患者。研究人员收集了入院时和出院时的人口统计学数据、生命体征和实验室检查结果。报告了每位患者所需的 PE 治疗次数、交换用量、置换类型、使用的静脉通路、并发症和结果。该系列包括 19 名患者,其中男性 10 人,女性 9 人,中位年龄和体重分别为 76 个月(IQR 18-121)和 20.9 公斤。平均血红蛋白从出院时的 5.3 ± 1.8 g/dl 提高到 9.9 ± 2.6 g/dl。PE 治疗的平均次数为 2.4 次,未出现不良反应。PICU 平均住院时间为 16.6 天。2名患者(10.5%)因原发病死亡,7名患者(36.8%)需要进一步接受免疫治疗,5名患者(28%)病情复发。对于对类固醇治疗无效或无法输注匹配的 PRBCs 的严重急性危及生命的 AIHA 患儿,PE 可作为一种安全、成功的疗法。
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引用次数: 0
Laparoscopy versus ultrasonography for the evaluation of Müllerian duct remnants in male patients with disorder of sex differentiation 腹腔镜检查与超声波检查在评估性别分化障碍男性患者残余穆勒氏管方面的比较
IF 0.8 Pub Date : 2024-05-27 DOI: 10.1186/s43054-024-00256-4
Mohamed Sayed Abd El-Monsif, Noha Arafa, Mahmoud Marei Marei, Gamal Eltagy, Ahmed M. K. Wishahy
The diagnosis of male differences of sex development is a challenging multidisciplinary team task, that requires external genital evaluation, karyotyping, hormonal profiling, radiological work up and frequently diagnostic laparoscopy and biopsy, for evaluation of internal duct system and nature of gonads. The debate still persists regarding the best diagnostic modality for accurate visualization of Müllerian duct remnants (MDRs) in those patients. The aim of the study was to compare between laparoscopy (L) and ultrasonography (US) regarding the diagnostic accuracy in detection of Müllerian duct remnants, in addition to describing their anatomical nature and relations with the male duct system, in patients with male DSD, with various karyotypes. We prospectively included 20 patients with male DSD, mostly due to 46 XY DSD or chromosomal DSD, over 2 years. The medical and radiological data were collected and analyzed. The age at the first diagnostic intervention ranged from 8 to 24 months (mean: 17 months). There were 14 patients with 46XY DSD with variable diagnoses (3 ovotesticular DSD, 3 partial gonadal dysgenesis, 6 persistent Müllerian duct remnants syndrome and 2 mixed gonadal dysgenesis). Two patients with 46XX DSD were included (one XX male, and one patient with ovotesticular DSD). One patient with chimerism (46XY/46XX) and three patients with 46XY/45XO mixed gonadal dysgenesis were also recruited. MDRs were evident in all cases (100%) by laparoscopy, only 25% (n = 5) were visualized by US. There was a statistically significant difference between laparoscopy and US regarding gonadal and MDR visualization, being higher with laparoscopy (p values, 0.0180 and 0.001). Ultrasonography failed to visualize Müllerian remnants in 75% of patients with complex DSD. On the other hand, laparoscopy provided optimum visualization of MDRs and gonads in those children.
男性性发育差异的诊断是一项具有挑战性的多学科团队工作,需要进行外生殖器评估、核型分析、激素分析、放射学检查,并经常需要进行诊断性腹腔镜检查和活组织检查,以评估内导管系统和性腺的性质。关于如何采用最佳诊断方法准确观察这些患者的缪勒氏管残余(MDR),目前仍存在争议。本研究旨在比较腹腔镜检查(L)和超声波检查(US)在检测男性DSD患者残余缪勒管方面的诊断准确性,同时描述残余缪勒管的解剖性质及其与男性生殖管道系统的关系。我们对20名男性DSD患者进行了为期两年的前瞻性研究,其中大部分是46 XY DSD或染色体DSD患者。我们收集并分析了医学和放射学数据。首次接受诊断干预的患者年龄从 8 个月到 24 个月不等(平均:17 个月)。14 名 46XY DSD 患者的诊断结果各不相同(3 名卵巢 DSD、3 名部分性腺发育不良、6 名持续性穆勒氏管残留综合征和 2 名混合性性腺发育不良)。其中包括两名 46XX DSD 患者(一名 XX 男性,一名卵巢 DSD 患者)。此外,还招募了一名嵌合体(46XY/46XX)患者和三名 46XY/45XO 混合性性腺发育不良患者。所有病例(100%)的腹腔镜检查均可发现多发性生殖器发育不良,只有 25% 的病例(5 例)的腹腔镜检查可发现多发性生殖器发育不良。腹腔镜检查和超声检查在性腺和多发性生殖器发育不良的可视化程度上有显著的统计学差异,腹腔镜检查的可视化程度更高(P值分别为0.0180和0.001)。在75%的复杂DSD患者中,超声波检查未能观察到缪勒氏残余。而腹腔镜检查则能最佳地观察到这些儿童的MDR和性腺。
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引用次数: 0
Vertebral compression fracture as the only presentation sign of acute lymphoblastic leukemia: a case report 作为急性淋巴细胞白血病唯一表现症状的椎体压缩性骨折:一份病例报告
IF 0.8 Pub Date : 2024-05-24 DOI: 10.1186/s43054-024-00277-z
Dana Kanaan, Reem Abuzraiq, Abdullah Abu-Aqoulah, Hanan Al-Thiabat, S. Al-Sweedan
{"title":"Vertebral compression fracture as the only presentation sign of acute lymphoblastic leukemia: a case report","authors":"Dana Kanaan, Reem Abuzraiq, Abdullah Abu-Aqoulah, Hanan Al-Thiabat, S. Al-Sweedan","doi":"10.1186/s43054-024-00277-z","DOIUrl":"https://doi.org/10.1186/s43054-024-00277-z","url":null,"abstract":"","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative evaluation of the persistent urogenital sinus in cases with congenital adrenal hyperplasia 对先天性肾上腺皮质增生症病例中的持续性尿道窦进行术前评估
IF 0.8 Pub Date : 2024-05-22 DOI: 10.1186/s43054-024-00262-6
Abeer Aboalazayem, A. E. Fares, Samah Ahmed Hassanein Ahmed, S. Kaddah, K. Abdullateef
{"title":"Preoperative evaluation of the persistent urogenital sinus in cases with congenital adrenal hyperplasia","authors":"Abeer Aboalazayem, A. E. Fares, Samah Ahmed Hassanein Ahmed, S. Kaddah, K. Abdullateef","doi":"10.1186/s43054-024-00262-6","DOIUrl":"https://doi.org/10.1186/s43054-024-00262-6","url":null,"abstract":"","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141112092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends and risk factors analysis of NEC in preterm infants over 9 years 9 年间早产儿 NEC 的趋势和风险因素分析
IF 0.8 Pub Date : 2024-05-15 DOI: 10.1186/s43054-024-00261-7
Yi Yang, Qing He, Min Yang, Pinglin Zhang, Lijun Su, Yong Lin
{"title":"Trends and risk factors analysis of NEC in preterm infants over 9 years","authors":"Yi Yang, Qing He, Min Yang, Pinglin Zhang, Lijun Su, Yong Lin","doi":"10.1186/s43054-024-00261-7","DOIUrl":"https://doi.org/10.1186/s43054-024-00261-7","url":null,"abstract":"","PeriodicalId":43064,"journal":{"name":"Egyptian Pediatric Association Gazette","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of ultrasonography in predicting contralateral patent processus vaginalis compared with laparoscopic findings in children 与腹腔镜检查结果相比,超声波检查在预测儿童对侧阴道前突方面的准确性
IF 0.8 Pub Date : 2024-05-08 DOI: 10.1186/s43054-024-00258-2
Abeer Aboalazayem, Hadeel Seif, Sherif Kaddah, Mohamed Elbarbary, Ahmed MK Wishahy
The study aims to evaluate the usefulness of preoperative ultrasonography (US) at the internal inguinal ring level in predicting contralateral patent processus vaginalis (CPPV). This is a prospective study of patients who presented with unilateral inguinal hernia and underwent laparoscopic hernia repair and contralateral side exploration. The gender, age, initial presenting side, and the preoperative width of the low echoic region at the internal ring (WLIR) of the contralateral side that was determined using US and laparoscopic findings were recorded. The preoperative diagnosis of CPPV was considered if the WLIR is > 4 mm. We compared laparoscopic with US findings. This study included 30 patients with a median age of 3.5 years (range, 25 days to 10 years), with 3 females and 27 males. The preoperative US and laparoscopic diagnoses of the contralateral side were concordant in 19 (63.3%) and discordant in 11 (36.6%) patients. US showed a sensitivity of 50.00%, specificity of 72.22%, and accuracy of 63.3% in diagnosing CPPV. Measuring the WLIR by US was inadequate for an accurate CPPV diagnosis in our study. Therefore, more distinctive US criteria are required for a proper CPPV diagnosis.
本研究旨在评估术前腹股沟内环水平超声波成像(US)在预测对侧阴道前突(CPPV)方面的作用。这是一项前瞻性研究,研究对象为单侧腹股沟疝并接受腹腔镜疝修补术和对侧探查术的患者。研究记录了患者的性别、年龄、最初发病的一侧,以及术前使用 US 和腹腔镜检查结果确定的对侧内环低回声区(WLIR)的宽度。如果 WLIR > 4 mm,则认为术前诊断为 CPPV。我们比较了腹腔镜和超声检查的结果。本研究共纳入 30 名患者,中位年龄为 3.5 岁(25 天至 10 岁),其中女性 3 名,男性 27 名。术前美学诊断和腹腔镜诊断对侧一致的患者有 19 人(63.3%),不一致的患者有 11 人(36.6%)。US 对 CPPV 诊断的敏感性为 50.00%,特异性为 72.22%,准确性为 63.3%。在我们的研究中,通过 US 测量 WLIR 不足以准确诊断 CPPV。因此,正确诊断 CPPV 需要更明确的 US 标准。
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引用次数: 0
Management of uretero-colonic fistulas and ureteral injuries: a comprehensive surgical and endoscopic approach 输尿管结肠瘘和输尿管损伤的处理:外科和内窥镜综合方法
IF 0.8 Pub Date : 2024-05-06 DOI: 10.1186/s43054-024-00280-4
Jose Luis Gonzalez Chavez, Pedro Salvador Jiménez Urueta, Edgar Melo Camacho, Sofia Brenes Guzmán
Pediatric ureteral injuries can arise from trauma or surgical procedures, and urinary-enteral fistulas, although rare, are both challenging to manage and repair. More information is needed regarding ureteral-enteral fistulas in the general population, and successful treatment options are limited. This case report introduces an innovative approach, treatment, and successful follow-up featuring a novel repair technique designed for pediatric patients. As a result of complicated appendicitis, a 2-year-old male developed a uretero-enteral fistula. A right ureteral-enteral fistula was detected, and because of the persistent metabolic acidosis and deteriorating malnourishment, a percutaneous nephrostomy tube was inserted with the closure of the fistula through a colonoscopy clip. Three months later, with a better patient’s condition, corrective ureteral surgery was performed with total resection of the fistulized ileocolonic segment (an anastomosis previously made because of the ileocecal valve resection secondary to appendiceal process) and total reconstruction of the urinary tract using a Boari vesical flap. The postoperative course was satisfactory. Managing the ureteral-enteral fistulas is a surgical challenge due to their diverse etiology and presentation. An effective surgical management plan requires a comprehensive understanding of ureteral injuries and associated conditions and an examination of the patient's urological anatomy and function to tailor the best treatment for each case.
小儿输尿管损伤可能源于外伤或外科手术,输尿管-肛门瘘虽然罕见,但在处理和修复方面都具有挑战性。我们需要更多有关普通人群输尿管-肠瘘的信息,而且成功的治疗方案也很有限。本病例报告介绍了一种创新的方法、治疗和成功的后续治疗,其特点是采用了专为儿童患者设计的新型修复技术。一名两岁男童因并发阑尾炎导致输尿管-肠瘘。由于持续的代谢性酸中毒和营养不良,医生通过结肠镜夹闭瘘管,插入了经皮肾造瘘管。三个月后,患者的情况好转,于是进行了输尿管矫正手术,全切除了瘘管化的回结肠段(之前因阑尾炎切除回盲部瓣膜而进行了吻合),并使用 Boari 膀胱瓣重建了整个尿路。术后效果令人满意。输尿管-肠瘘的病因和表现多种多样,因此治疗输尿管-肠瘘是一项外科挑战。有效的手术治疗方案需要全面了解输尿管损伤和相关疾病,并检查患者的泌尿系统解剖结构和功能,从而为每个病例量身定制最佳治疗方案。
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引用次数: 0
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Egyptian Pediatric Association Gazette
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