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Immune aspects of the breast tumor microenvironment. 乳腺肿瘤微环境的免疫方面。
IF 0.7 Q4 ONCOLOGY
Breast Cancer Management
Pub Date : 2013-05-01 DOI: 10.2217/bmt.13.15
Akhil Chawla, Gheath Alatrash, Yun Wu, Elizabeth A Mittendorf

The immune response in the tumor microenvironment is complex, consisting of cells from both the adaptive and innate immune systems. The phenotype and function of these cells are dictated by cytokines present in the microenvironment, as well as by the interactions of these cells with the tumor cells and each other. Technological advances have allowed investigators to better identify the specific immune cells present and immune-related gene signatures overexpressed in the tumor microenvironment. Increased knowledge of tumor immunology has allowed us to better understand how these cells and the developing tumor interact. Together, these advances have prompted the conduct of numerous studies investigating the prognostic and predictive significance of immune infiltrates.

肿瘤微环境中的免疫反应是复杂的，包括来自适应性和先天免疫系统的细胞。这些细胞的表型和功能取决于微环境中存在的细胞因子，以及这些细胞与肿瘤细胞和彼此之间的相互作用。技术进步使研究人员能够更好地识别肿瘤微环境中存在的特异性免疫细胞和过度表达的免疫相关基因特征。肿瘤免疫学知识的增加使我们能够更好地了解这些细胞和发展中的肿瘤是如何相互作用的。总之，这些进展促使进行了大量研究，调查免疫浸润的预后和预测意义。
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引用次数: 11
The role of radiotherapy-resistant stem cells in breast cancer recurrence. 耐放疗干细胞在乳腺癌复发中的作用。
IF 0.7 Q4 ONCOLOGY
Breast Cancer Management
Pub Date : 2013-01-01 DOI: 10.2217/bmt.13.5
Cheikh Menaa, Jian Jian Li
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引用次数: 13
Breast cancer survivorship symptom management: current perspective and future development. 乳腺癌幸存者症状管理：当前视角与未来发展。
IF 0.7 Q4 ONCOLOGY
Breast Cancer Management
Pub Date : 2013-01-01 DOI: 10.2217/bmt.12.63
G van Londen, Eb Beckjord, Ma Dew, P Cuijpers, S Tadic, A Brufsky

Increasing numbers and longevity of cancer survivors has furthered our insight into the factors affecting their health outcomes, suggesting that multiple factors play a role (e.g., effects of cancer treatments and health behaviors). Emotional and physical symptoms may not always receive sufficient attention. In this short narrative review highlighting recent literature, we describe the most common physical and emotional symptoms of breast cancer survivors aged 50 years and older and outline a multidisciplinary symptom management approach, regardless of symptom etiology.

癌症幸存者人数的增加和寿命的延长使我们对影响其健康结果的因素有了更深入的了解，这表明有多种因素在起作用（如癌症治疗和健康行为的影响）。情绪和身体症状可能并不总能得到足够的重视。在这篇简短的叙述性综述中，我们重点回顾了近期的文献，描述了 50 岁及以上乳腺癌幸存者最常见的身体和情绪症状，并概述了一种多学科症状管理方法，无论症状的病因是什么。
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引用次数: 0
Using large-scale molecular data sets to improve breast cancer treatment. 利用大规模分子数据集改善乳腺癌治疗。
IF 0.7 Q4 ONCOLOGY
Breast Cancer Management
Pub Date : 2012-05-01 DOI: 10.2217/BMT.12.14
Chad J Creighton

The treatment of breast cancer patients could potentially be advanced by having a more complete understanding of breast cancer biology, including a catalog of recurrently altered genes. Over the last decade, thousands of human breast tumors have been profiled for gene expression and DNA copy number alterations, and ongoing efforts in DNA sequencing are establishing the set of somatically mutated genes. Much of the molecular data being generated resides in the public domain, available as a resource for further research. The challenge then becomes how to best utilize all these data, to mine them for candidate biomarkers and targets, which is the subject of this review. Some examples of integrative analysis and combining results from diverse data sets are also presented.

如果对乳腺癌生物学有了更全面的了解，包括对反复改变的基因的目录有了更全面的了解，乳腺癌患者的治疗就有可能取得进展。在过去的十年中，成千上万的人类乳腺肿瘤已经被描述为基因表达和DNA拷贝数改变，并且正在进行的DNA测序工作正在建立一组体细胞突变基因。生成的许多分子数据驻留在公共领域，可作为进一步研究的资源。接下来的挑战是如何最好地利用所有这些数据，挖掘候选生物标志物和靶标，这是本文的主题。还介绍了一些综合分析和结合不同数据集结果的例子。
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引用次数: 3
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