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Does food responsiveness change in people with first-episode psychosis over a period of 3 months after commencing antipsychotics? Preliminary results. 在开始服用抗精神病药物后的3个月内,首次发作的精神病患者的食物反应性是否发生了变化?初步结果。
IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-12-08 eCollection Date: 2023-03-01 DOI: 10.1097/XCE.0000000000000274
Adrian Heald, Mark Shakespeare, Adrian Phillipson, Janet Cade, Petra Netter, Suzanne Higgs
Adrian H. Heald, Mark Shakespeare, Adrian Phillipson, Janet Cade, Petra Netter and Suzanne Higgs Department of Diabetes and Endocrinology, Salford Royal Hospital, Salford, The School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, Rotherham, Doncaster and South Humber (RDASH) NHS Foundation Trust, Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, Department of Psychology, University of Giessen, Germany, School of Psychology, College of Life and Environmental Sciences, University of Birmingham, UK
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引用次数: 0
Cardiac autonomic neuropathy linked to left ventricular dysfunction in type 1 diabetic patients. 1型糖尿病患者与左心室功能障碍相关的心脏自主神经病变
IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-09-20 eCollection Date: 2022-12-01 DOI: 10.1097/XCE.0000000000000272
Amira El Tantawy, Ghada Anwar, Reem Esmail, Hanan Zekri, Samar Mahmoud, Nancy Samir, Amr Fathalla, Mary Maher, Antoine F AbdelMassih
Introduction Type 1 diabetes is a major cause of cardiovascular death; diabetic cardiomyopathy (DCM) is the most important cause of mortality among diabetic patients. There is an increasing body of evidence that the most important inducer of DCM is microvascular injury. The aim of this study is to establish a potential relationship between low frequency/high frequency (LF/HF) ratio and DCM and to set a possible predictive cutoff of LF:HF ratio for early detection of DCM. Methods 75 type 1 diabetic patients together with 75 controls were assessed using tissue Doppler imaging for left ventricular (LV) and right ventricular (RV) diastolic function, and heart rate variability (HRV) indices including LF/HF ratio. Type 1 diabetic patients were also assessed for parameters of glycemic and lipid profile control. Results Cases showed a statistically significant increase in LF/HF ratio compared to controls reflecting reduced HRV. Also, LV and RV diastolic function were reduced in cases compared to controls, there was a significant correlation between LV E/E’ ratio (ratio of early transmitral velocity and average early mitral annular and basal septal velocities) and LF/HF ratio. LF/HF ratio was able to predict LV diastolic dysfunction as expressed by the LV E/E’ ratio with a sensitivity of 96%. Conclusion HRV indices notably LF/HF ratio seem to be an early and sensitive predictor of DCM, the latter finding not only underlines the role of microvascular injury in the induction of DCM but might help also for the early detection and reversal of it.
1型糖尿病是心血管死亡的主要原因;糖尿病性心肌病(DCM)是糖尿病患者最主要的死亡原因。越来越多的证据表明,DCM最重要的诱发因素是微血管损伤。本研究的目的是建立低频/高频(LF/HF)比值与DCM之间的潜在关系,并为早期发现DCM设定LF:HF比值的可能预测截止值。方法:采用组织多普勒成像技术对75例1型糖尿病患者及75例对照组左室(LV)、右室(RV)舒张功能及LF/HF比值等心率变异性(HRV)指标进行评估。同时对1型糖尿病患者的血糖和血脂控制参数进行评估。结果:病例显示,与对照组相比,LF/HF比值显著增加,反映HRV降低。此外,与对照组相比,这些病例的左室和右室舒张功能降低,左室E/E’比(早期传递速度与平均早期二尖瓣环和基底间隔速度之比)和LF/HF比值具有显著相关性。LF/HF比值能够预测左室舒张功能障碍,以左室E/E比值表示,敏感性为96%。结论:HRV指标特别是LF/HF比值是DCM的早期敏感预测指标,后者的发现不仅强调了微血管损伤在DCM诱导中的作用,而且可能有助于DCM的早期发现和逆转。
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引用次数: 1
Response to the report published by the UK House of Commons All-Party Parliamentary Group on Chronic Fatigue Syndrome/Myalgic Encephalitis (CFS/ME): implications for cardiometabolic risk. 对英国下议院跨党派议会小组关于慢性疲劳综合征/肌痛性脑炎(CFS/ME)的报告的回应:对心脏代谢风险的影响。
IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-09-20 eCollection Date: 2022-12-01 DOI: 10.1097/XCE.0000000000000271
Sara Low, Nathan Brookes, Adrian H Heald
2574-0954 Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. DOI: 10.1097/XCE.0000000000000271 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBYNC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Correspondence
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引用次数: 0
National level prescribing of psychotropic medication in primary care during the COVID-19 pandemic in England: potential implications for cardiometabolic health. 英格兰COVID-19大流行期间初级保健中精神药物的国家级处方:对心脏代谢健康的潜在影响
IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-09-05 eCollection Date: 2022-12-01 DOI: 10.1097/XCE.0000000000000270
Unaiza Waheed, Mike Stedman, Mark Davies, Andreas Walther, Emma Solomon, Bill Ollier, Adrian H Heald
2574-0954 Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBYNC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Correspondence
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引用次数: 1
Treatment of acute upper gastrointestinal bleeding occurred after percutaneous coronary intervention for acute myocardial infarction in patients with acute renal impairment: a case report. 急性肾损害患者急性心肌梗死经皮冠状动脉介入治疗后急性上消化道出血1例
IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-08-10 eCollection Date: 2022-09-01 DOI: 10.1097/XCE.0000000000000269
Rong Wu, Jinhua Li, Yuhuang Guo

Upper gastrointestinal (UGI) bleeding after percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) in ordinary patients is a common complication and poses a dilemma for clinical doctors to treat. In patients with renal impairment, that is more difficult and has rarely been reported. This case report involves an 82-year-old man who received regular hemodialysis and underwent PCI for acute inferior wall ST-segment elevation myocardial infarction. On the third day after PCI, the patient developed acute UGI bleeding, and gastroscopy confirmed that he had developed compound gastroduodenal ulcers (active stage) with hyperemia of the surrounding mucosa. After fasting, blood transfusion, acid inhibition, gastric protection and symptomatic support treatment, the patient's UGI bleeding remained uncontrolled. Finally, upper gastrointestinal bleeding was stopped by empiric transcatheter arterial embolization (TAE). The patient's condition was controlled through active treatment, and he was eventually discharged from the hospital. Bleeding complications after coronary stenting often present a dilemma, particularly in patients with renal impairment. Therefore, patients such as this should be thoroughly evaluated before any treatment. In the case of no obvious hemorrhagic spots found on endoscopic examination and failure of conservative medical treatment, empiric transcatheter arterial embolization TAE is a well-tolerated and effective treatment for UGI bleeding.

急性心肌梗死(AMI)普通患者经皮冠状动脉介入治疗(PCI)后上消化道出血是一种常见的并发症,也是困扰临床医生的难题。对于肾功能受损的患者,这就比较困难了,很少有报道。本病例报告涉及一名82岁男性,因急性下壁st段抬高性心肌梗死接受常规血液透析并行PCI。PCI术后第3天,患者出现急性UGI出血,胃镜检查证实为复合胃十二指肠溃疡(活动期)伴周围粘膜充血。经禁食、输血、抑酸、保胃及对症支持治疗后,患者UGI出血仍未得到控制。最后,通过经验性经导管动脉栓塞术(TAE)止住上消化道出血。通过积极治疗,患者病情得到控制,最终出院。冠状动脉支架植入术后的出血并发症通常是一个难题,特别是在肾功能受损的患者中。因此,在进行任何治疗之前,应对此类患者进行彻底评估。在内窥镜检查未发现明显出血点,保守治疗失败的情况下,经验性经导管动脉栓塞TAE是一种耐受性良好且有效的UGI出血治疗方法。
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引用次数: 1
Enhancing type 2 diabetes treatment through digital plans of care. First results from the East Cheshire Study of an App to support people in the management of type 2 diabetes. 通过数字化护理计划加强2型糖尿病的治疗。来自东柴郡的应用程序研究的第一个结果,以支持人们管理2型糖尿病。
IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-07-19 eCollection Date: 2022-09-01 DOI: 10.1097/XCE.0000000000000268
Adrian H Heald, Lucia Albeda Gimeno, Erin Gilingham, Lynne Hudson, Lisa Price, Anuj Saboo, Laura Beresford, Sally Seviour, Alison White, Sarah Roberts, Jonathan Abraham

Introduction: The use of personalised care planning has been effective at improving health outcomes for people with long-term health conditions.

Methods: We analysed data in relation to changes in BMI/HbA1c. The sample was made up of (n = 36) participants randomised to either the active intervention group (App+usual care) or the control group (usual care).

Results: The average HbA1c percentage change for the treatment group was 9.5%, but just -2% for the control (usual care) group (P = 0.015 for the difference). The average percentage change in BMI for the treatment group was -0.4%, but 0.1% for the control group (P = 0.03 for the difference).

Conclusion: These preliminary findings point to how the provision of personalised plans of care, support and education linked to a mobile app, can result in HbA1c and BMI reduction over a 6-month period. While the results are preliminary, they portend the potential for digital plans of care to enhance T2DM management.

个性化护理计划的使用在改善长期健康状况患者的健康结果方面是有效的。方法:我们分析了与BMI/HbA1c变化相关的数据。样本由(n = 36)名参与者组成,随机分为积极干预组(App+常规护理)或对照组(常规护理)。结果:治疗组的平均HbA1c百分比变化为9.5%,而对照组(常规护理)仅为-2% (P = 0.015)。治疗组BMI的平均百分比变化为-0.4%,而对照组为0.1% (P = 0.03)。结论:这些初步研究结果表明,提供与移动应用程序相关联的个性化护理、支持和教育计划,可以在6个月内降低HbA1c和BMI。虽然结果是初步的,但它们预示着数字护理计划加强2型糖尿病管理的潜力。
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引用次数: 2
Preexisting atrial fibrillation and myocardial infarction: only 10% of infarcts directly linked to atrial fibrillation. 先前存在的房颤和心肌梗死:只有10%的梗死与房颤直接相关。
IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-06-28 eCollection Date: 2022-09-01 DOI: 10.1097/XCE.0000000000000267
Alain Putot, Antoine Monin, Alban Belkouche, Frédéric Chagué, Marianne Zeller, Yves Cottin

The aim of the study was to evaluate the incidence and prognosis of type 1 myocardial infarction (T1MI) and type 2 MI (T2MI) in patients with acute MI and known atrial fibrillation (AF) to identify MI directly linked to AF. Among the 669 patients, four patients with hyperthyroidism were excluded, and among the remaining 665 patients, about two-thirds were diagnosed with T1MI, and the remaining third were diagnosed with T2MI. AF was the direct cause of MI in 9.8% of our overall population [1.8% of T1MI type C (coronary embolism), 4.9% of T2MI type A and 3.1% of T2MI type B]. Among patients with T2MI, 30-day mortality was lower when the trigger was AF than for the other triggers, for both type 2A (6% vs. 11%) and type 2B (0% vs. 13%). Most cases of AF-related MI are, thus, T2MI, for which therapeutic guidelines are lacking. Given the diverse triggers in T2MI, a specific approach using etiological patterns is needed to properly determine the optimal therapeutic.

本研究的目的是评估急性心肌梗死(T1MI)和已知心房颤动(AF)患者的1型心肌梗死(T1MI)和2型心肌梗死(T2MI)的发生率和预后,以确定与房颤直接相关的心肌梗死。在669例患者中,排除了4例甲状腺功能亢进患者,在其余665例患者中,约三分之二诊断为T1MI,其余三分之一诊断为T2MI。房颤是9.8%的人群中发生心肌梗死的直接原因[占T1MI C型(冠状动脉栓塞)的1.8%,占T1MI A型的4.9%,占T2MI B型的3.1%]。在T2MI患者中,无论是2A型(6%对11%)还是2B型(0%对13%),当触发AF时,30天死亡率都低于其他触发AF的患者。因此,大多数心房颤动相关的心肌梗死是T2MI,缺乏治疗指南。考虑到T2MI的多种诱因,需要使用病因模式的特定方法来正确确定最佳治疗方案。
{"title":"Preexisting atrial fibrillation and myocardial infarction: only 10% of infarcts directly linked to atrial fibrillation.","authors":"Alain Putot,&nbsp;Antoine Monin,&nbsp;Alban Belkouche,&nbsp;Frédéric Chagué,&nbsp;Marianne Zeller,&nbsp;Yves Cottin","doi":"10.1097/XCE.0000000000000267","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000267","url":null,"abstract":"<p><p>The aim of the study was to evaluate the incidence and prognosis of type 1 myocardial infarction (T1MI) and type 2 MI (T2MI) in patients with acute MI and known atrial fibrillation (AF) to identify MI directly linked to AF. Among the 669 patients, four patients with hyperthyroidism were excluded, and among the remaining 665 patients, about two-thirds were diagnosed with T1MI, and the remaining third were diagnosed with T2MI. AF was the direct cause of MI in 9.8% of our overall population [1.8% of T1MI type C (coronary embolism), 4.9% of T2MI type A and 3.1% of T2MI type B]. Among patients with T2MI, 30-day mortality was lower when the trigger was AF than for the other triggers, for both type 2A (6% vs. 11%) and type 2B (0% vs. 13%). Most cases of AF-related MI are, thus, T2MI, for which therapeutic guidelines are lacking. Given the diverse triggers in T2MI, a specific approach using etiological patterns is needed to properly determine the optimal therapeutic.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":" ","pages":"e0267"},"PeriodicalIF":2.3,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40581661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A retrospective real-world observational pilot analysis of Waya: a self-monitoring fitness app in Germany. 对Waya的回顾性现实世界观察性试点分析:德国的一款自我监测健身应用程序。
IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-06-10 eCollection Date: 2022-09-01 DOI: 10.1097/XCE.0000000000000266
Preetha Balakrishnan, Elizabeth Owen, Markus Eberl, Benjamin Friedrich, Tobias Etter

The increasing prevalence of lifestyle-driven metabolic disorders poses a heavy burden on the healthcare system. Several low-cost, easily accessible, and effective weight loss interventions are being developed to improve this situation. Waya is one such German digital application that guides users to reach their desired weight in a healthy manner, by monitoring their eating habits and physical activity levels. In this retrospective real-world observational pilot study, we aimed to identify if the use of Waya helps in reducing weight as intended and the underlying factors associated with it.

Methods: Data from healthy overweight or obese participants who provided their weight information and answered the short form of the Weight Efficacy Lifestyle Questionnaire and the International Physical Activity Questionnaire activity questionnaires once before the completion of the first module (baseline) were compared with data provided after the beginning of the last module. Age and sex-based distribution were studied and the correlation between nutrition, physical activity, and weight was analyzed.

Results: Waya participants showed an improvement in nutritional behavior, physical activity levels, and weight reduction compared with baseline. These changes were independent of age and sex. Weight loss mainly correlated with improvements in nutritional behavior but not physical activity.

Conclusion: The results from our pilot study showed that Waya is beneficial in bringing about short-term weight loss mainly through behavioral changes in nutrition. Although physical activity levels improved, its influence on weight loss was not apparent.

日益流行的生活方式驱动的代谢紊乱对医疗保健系统造成了沉重的负担。为了改善这种状况,正在开发几种低成本、容易获得和有效的减肥干预措施。Waya就是这样一个德国数字应用程序,它通过监测用户的饮食习惯和体育活动水平,指导用户以健康的方式达到理想的体重。在这项回顾性的现实世界观察性试点研究中,我们旨在确定使用Waya是否有助于减肥,以及与之相关的潜在因素。方法:健康超重或肥胖参与者在完成第一个模块(基线)之前提供体重信息,并回答一次体重功效生活方式问卷和国际体育活动问卷的简短形式,将数据与最后一个模块开始后提供的数据进行比较。研究了年龄和性别分布,并分析了营养、体力活动和体重之间的相关性。结果:与基线相比,Waya参与者在营养行为、身体活动水平和体重减轻方面都有所改善。这些变化与年龄和性别无关。体重减轻主要与营养行为的改善有关,而与体育活动无关。结论:我们的前期研究结果表明,Waya主要通过改变营养行为来实现短期减肥。尽管体育锻炼水平有所提高,但其对减肥的影响并不明显。
{"title":"A retrospective real-world observational pilot analysis of Waya: a self-monitoring fitness app in Germany.","authors":"Preetha Balakrishnan,&nbsp;Elizabeth Owen,&nbsp;Markus Eberl,&nbsp;Benjamin Friedrich,&nbsp;Tobias Etter","doi":"10.1097/XCE.0000000000000266","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000266","url":null,"abstract":"<p><p>The increasing prevalence of lifestyle-driven metabolic disorders poses a heavy burden on the healthcare system. Several low-cost, easily accessible, and effective weight loss interventions are being developed to improve this situation. Waya is one such German digital application that guides users to reach their desired weight in a healthy manner, by monitoring their eating habits and physical activity levels. In this retrospective real-world observational pilot study, we aimed to identify if the use of Waya helps in reducing weight as intended and the underlying factors associated with it.</p><p><strong>Methods: </strong>Data from healthy overweight or obese participants who provided their weight information and answered the short form of the Weight Efficacy Lifestyle Questionnaire and the International Physical Activity Questionnaire activity questionnaires once before the completion of the first module (baseline) were compared with data provided after the beginning of the last module. Age and sex-based distribution were studied and the correlation between nutrition, physical activity, and weight was analyzed.</p><p><strong>Results: </strong>Waya participants showed an improvement in nutritional behavior, physical activity levels, and weight reduction compared with baseline. These changes were independent of age and sex. Weight loss mainly correlated with improvements in nutritional behavior but not physical activity.</p><p><strong>Conclusion: </strong>The results from our pilot study showed that Waya is beneficial in bringing about short-term weight loss mainly through behavioral changes in nutrition. Although physical activity levels improved, its influence on weight loss was not apparent.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":" ","pages":"e0266"},"PeriodicalIF":2.3,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1d/90/xce-11-e0266.PMC9213173.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40399969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Can glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors help in mitigating the risk of atrial fibrillation in patients with diabetes? 胰高血糖素样肽-1受体激动剂和二肽基肽酶-4抑制剂是否有助于减轻糖尿病患者房颤的风险?
IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-06-08 DOI: 10.1097/XCE.0000000000000265
S. Thotamgari, U. Grewal, A. Sheth, Akhilesh Babbili, Paari Dominic
The role of glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i) in mitigating the risk of atrial fibrillation (AF) remains unknown. We interrogated the Food and Drug Administration’s Adverse Event Reporting System (FAERS) database to study the association between AF-related adverse events and the use of GLP-1 RA and DPP-4i. A signal of disproportionate reporting of AF was detected with the DPP-4i group compared with all the other drugs in the FAERS database [ROR, 2.56; 95% confidence interval (CI), 2.10–3.12], whereas there was no disproportionality signal detected with the GLP-1 RA group (ROR, 0.90; 95% CI, 0.78–1.03) although liraglutide showed a significant disproportionality signal (ROR, 2.51; 95% CI, 2.00–3.15). Our analysis supports the existing body of literature demonstrating the cardiac safety of GLP-1 RA but raises concerns about the apparent increase in the risk of AF associated with DPP-4i. Further clinical and translational studies are needed to validate these findings.
胰高血糖素样肽-1受体激动剂(GLP-1 RA)和二肽基肽酶-4抑制剂(DPP-4i)在降低心房颤动(AF)风险方面的作用尚不清楚。我们询问了美国食品药品监督管理局的不良事件报告系统(FAERS)数据库,以研究房颤相关不良事件与GLP-1 RA和DPP-4i的使用之间的关系。与FAERS数据库中的所有其他药物相比,DPP-4i组检测到房颤报告不成比例的信号[ROR,2.56;95%置信区间(CI),2.10–3.12],尽管利拉鲁肽显示出明显的不均衡信号(ROR,2.51;95%CI,2.00–3.15),但GLP-1 RA组未检测到不均衡信号DPP-4i。需要进一步的临床和转化研究来验证这些发现。
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引用次数: 3
Glucose dysregulation and repolarization variability markers are short-term mortality predictors in decompensated heart failure 葡萄糖失调和复极化变异性标记物是失代偿性心力衰竭的短期死亡率预测因子
IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-05-30 DOI: 10.1097/XCE.0000000000000264
G. Piccirillo, F. Moscucci, M. Carnovale, A. Corrao, I. Di Diego, I. Lospinuso, S. Sciomer, P. Rossi, D. Magrí
Objective As recently reported, elevated fasting glucose plasma level constitutes a risk factor for 30-day total mortality in acutely decompensated chronic heart failure (CHF). Aim of this study was to evaluate the 30-day mortality risk in decompensated CHF patients by fasting glucose plasma level and some repolarization ECG markers. Method A total of 164 decompensated CHF patients (M/F: 94/71; mean age, 83 ± 10 years) were studied; Tend (Te), QT interval (QT) and 5 min of ECG recordings were obtained, studying mean, SD and normalized index of the abovementioned ECG intervals. These repolarization variables and fasting glucose were analyzed to assess the 30-day mortality risk among these patients. Results Thirty-day mortality rate was 21%, deceased subjects showed a significant increase in N terminal-pro-brain natriuretic peptide (P < 0.001), higher sensitivity cardiac troponin, fasting glucose, creatinine clearance, QTSD, QTVN, Te mean, TeSD and TeVN than the survivals. Multivariable regression analysis reported that fasting glucose (hazard ratio, 1.59; 95% confidence interval, 1.09–2.10; P < 0.01), Te mean (hazard ratio, 1.03; 95% confidence interval, 1.01–1.05; P < 0.01) and QTSD (hazard ratio, 1.17; 95% confidence interval, 1.01–1.36; P < 0.05) were significantly related to higher mortality risk, whereas only fasting glucose (hazard ratio, 1.84; 95% confidence interval, 1.12–3.02; P < 0.05) and Te mean (hazard ratio, 1.07; 95% confidence interval, 1.02–1.11; P < 0.01) were associated to cardiovascular mortality. Conclusion Data suggest that two simple, inexpensive, noninvasive markers, as fasting glucose and Te, were capable to stratify the short-term total and cardiovascular mortality risk in acutely decompensated CHF.
最近有报道称,空腹血糖水平升高是急性失代偿性慢性心力衰竭(CHF)患者30天总死亡率的一个危险因素。本研究的目的是通过空腹血糖水平和一些复极心电图指标来评估失代偿期CHF患者30天死亡风险。方法164例失代偿期CHF患者(M/F: 94/71;平均年龄(83±10岁);取心电图的Tend (Te)、QT间期(QT)和5min记录,研究上述心电图间期的均值、标准差和归一化指数。对这些复极变量和空腹血糖进行分析,以评估这些患者的30天死亡风险。结果30天死亡率为21%,死亡患者N端脑钠肽前体明显高于生者(P < 0.001),心肌肌钙蛋白、空腹血糖、肌酐清除率、QTSD、QTVN、Te平均值、TeSD和TeVN的敏感性高于生者。多变量回归分析报告空腹血糖(风险比,1.59;95%置信区间为1.09-2.10;P < 0.01),平均(风险比1.03;95%置信区间为1.01-1.05;P < 0.01)和QTSD(风险比1.17;95%置信区间为1.01-1.36;P < 0.05)与较高的死亡风险显著相关,而仅与空腹血糖相关(危险比,1.84;95%置信区间为1.12-3.02;P < 0.05)和平均值(风险比1.07;95%置信区间为1.02-1.11;P < 0.01)与心血管死亡率相关。结论数据表明,空腹血糖和Te这两个简单、廉价、无创的指标能够对急性失代偿期CHF的短期总死亡风险和心血管死亡风险进行分层。
{"title":"Glucose dysregulation and repolarization variability markers are short-term mortality predictors in decompensated heart failure","authors":"G. Piccirillo, F. Moscucci, M. Carnovale, A. Corrao, I. Di Diego, I. Lospinuso, S. Sciomer, P. Rossi, D. Magrí","doi":"10.1097/XCE.0000000000000264","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000264","url":null,"abstract":"Objective As recently reported, elevated fasting glucose plasma level constitutes a risk factor for 30-day total mortality in acutely decompensated chronic heart failure (CHF). Aim of this study was to evaluate the 30-day mortality risk in decompensated CHF patients by fasting glucose plasma level and some repolarization ECG markers. Method A total of 164 decompensated CHF patients (M/F: 94/71; mean age, 83 ± 10 years) were studied; Tend (Te), QT interval (QT) and 5 min of ECG recordings were obtained, studying mean, SD and normalized index of the abovementioned ECG intervals. These repolarization variables and fasting glucose were analyzed to assess the 30-day mortality risk among these patients. Results Thirty-day mortality rate was 21%, deceased subjects showed a significant increase in N terminal-pro-brain natriuretic peptide (P < 0.001), higher sensitivity cardiac troponin, fasting glucose, creatinine clearance, QTSD, QTVN, Te mean, TeSD and TeVN than the survivals. Multivariable regression analysis reported that fasting glucose (hazard ratio, 1.59; 95% confidence interval, 1.09–2.10; P < 0.01), Te mean (hazard ratio, 1.03; 95% confidence interval, 1.01–1.05; P < 0.01) and QTSD (hazard ratio, 1.17; 95% confidence interval, 1.01–1.36; P < 0.05) were significantly related to higher mortality risk, whereas only fasting glucose (hazard ratio, 1.84; 95% confidence interval, 1.12–3.02; P < 0.05) and Te mean (hazard ratio, 1.07; 95% confidence interval, 1.02–1.11; P < 0.01) were associated to cardiovascular mortality. Conclusion Data suggest that two simple, inexpensive, noninvasive markers, as fasting glucose and Te, were capable to stratify the short-term total and cardiovascular mortality risk in acutely decompensated CHF.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44535102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Cardiovascular Endocrinology & Metabolism
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