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Clinical outcomes and associated risk factors of cataract surgeries in patients with diabetic macular edema: A real-world study 糖尿病性黄斑水肿患者白内障手术的临床结果和相关危险因素:一项真实世界的研究
Pub Date : 2023-01-01 DOI: 10.4103/njvd.njvd_2_23
S. Bassi, Shebin Salim, E. Rishi
Purpose: To evaluate the clinical outcome of phacoemulsification with intravitreal bevacizumab (IVB) injection in patients with cataract and diabetic macular edema (DME) and to evaluate the risk factors for poor visual outcome. Methods: Retrospective study of 63 eyes of 60 patients with cataract and DME who underwent phacoemulsification with IVB injection. Best corrected visual acuity (BCVA) and central macular thickness (CMT) over 3 months were studied. Univariate binary logistic regression was done to assess the risk factors for poor visual outcome (BCVA <6/60) at the 3 months. Results: The mean baseline BCVA in log Mar scale ± SD was 0.94 ± 0.58. The mean BCVA at 3 weeks after the surgery was 0.52 ±0.47, and at 3 months was 0.49±0.37. At 3 weeks, the mean CMT (N = 47) was 437.27±217.48 compared with the mean preoperative CMT of 380.87±176.38 in the same set (P = 0.01). The mean CMT at 3 months was 457.97 ± 206.94 (N=40) compared to preoperative mean CMT 435.45 ± 146.13 in the same set (p value 0.52). Fifteen eyes (23.8%) were given a second IVB at the 3-week follow-up. In these eyes, the mean preoperative and 3-month mean CMT were 413.73 and 377, respectively. The risk factors for poor visual outcome were, male gender [odds ratio (OR) 3.333], poor preoperative visual acuity (OR 8.42) and posterior capsular dehiscence (OR 5.1). Conclusions: Phacoemulsification with IVB injection improved the visual acuity at 3 weeks and 3 months but the mean CMT increased at 3 weeks and a decreased at 3 months only after the second IVB injection. Poor presenting visual acuity was an independent risk factor for poor visual outcome.
目的:评价白内障合并糖尿病性黄斑水肿(DME)患者玻璃体内注射贝伐单抗(IVB)超声乳化术的临床效果,并评价其视力不良的危险因素。方法:对60例63眼白内障合并二甲醚行IVB注射超声乳化术的患者进行回顾性研究。观察3个月最佳矫正视力(BCVA)和中央黄斑厚度(CMT)。采用单因素二元logistic回归评估3个月时视力不良(BCVA <6/60)的危险因素。结果:平均基线BCVA在log Mar量表±SD为0.94±0.58。术后3周平均BCVA为0.52±0.47,3个月平均BCVA为0.49±0.37。3周时,同一组患者的平均CMT (N = 47)为437.27±217.48,而术前平均CMT为380.87±176.38 (P = 0.01)。3个月时平均CMT为457.97±206.94 (N=40),同期术前平均CMT为435.45±146.13 (p值0.52)。15只眼(23.8%)在3周随访时接受第二次静脉注射。在这些眼睛中,术前和3个月的平均CMT分别为413.73和377。视力差的危险因素为男性[比值比(OR) 3.333]、术前视力差(OR 8.42)和后囊膜裂开(OR 5.1)。结论:IVB超声乳化术后3周和3个月的视力均有改善,但第二次IVB注射后,平均CMT在第3周增加,在第3个月下降。视力不佳是视力不佳的独立危险因素。
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引用次数: 0
Vitreoretinal Society of Nigeria participation in the Preferences and Trends Survey of the American Society of Retina Specialists 尼日利亚玻璃体视网膜协会参与美国视网膜专家协会的偏好和趋势调查
Pub Date : 2023-01-01 DOI: 10.4103/njvd.njvd_4_23
O. Okonkwo, O. Adenuga, Shuaib Abdulsalam
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引用次数: 0
Optical coherence tomography and optical coherence tomography angiography biomarkers for age-related macular degeneration and retinovascular diseases 光学相干断层扫描和光学相干断层扫描血管成像生物标志物与年龄相关的黄斑变性和视网膜血管疾病
Pub Date : 2023-01-01 DOI: 10.4103/njvd.njvd_3_23
M. Udoh, A. Okudo, O. Okonkwo
Optical coherence tomography (OCT) and OCT angiography (OCTA) play a vital role in diagnosing and posttreatment evaluation of several retina diseases, including age-related macular degeneration, diabetic retinopathy, and retinal vein occlusion, which are leading causes of retinal blindness. OCT provides a fast, noninvasive, and reproducible option for assessing retinal structure and gives high-resolution images that enable the identification of several biomarkers of retinal disease. Retinal biomarkers have been investigated extensively because of their usefulness in predicting the outcome and progression of disease. Recently, several biomarkers have been analyzed using artificial intelligence, which provides invaluable information on the natural history, prognosis, and risk of disease progression. Combining OCT/OCTA and artificial intelligence-based analytics will open doors to more personalized treatment and improved decision-making and, therefore, better outcomes for patients who suffer from retinal diseases. This review provides essential information on known retina biomarkers in leading retinal diseases.
光学相干断层扫描(OCT)和OCT血管造影(OCTA)在几种视网膜疾病的诊断和治疗后评估中起着至关重要的作用,包括老年性黄斑变性、糖尿病视网膜病变和视网膜静脉阻塞,这些疾病是导致视网膜失明的主要原因。OCT为评估视网膜结构提供了一种快速、无创、可重复的选择,并提供了高分辨率图像,使视网膜疾病的几种生物标志物得以识别。由于视网膜生物标志物在预测疾病的预后和进展方面的有用性,因此已被广泛研究。最近,使用人工智能分析了几种生物标志物,这提供了关于自然历史、预后和疾病进展风险的宝贵信息。结合OCT/OCTA和基于人工智能的分析将为更个性化的治疗和改进的决策打开大门,从而为患有视网膜疾病的患者带来更好的结果。本文综述了主要视网膜疾病中已知视网膜生物标志物的基本信息。
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引用次数: 0
Pigmented paravenous chorioretinal atrophy: A fortuitous finding in a patient with fronto-ethmoidal mucocoele 色素性静脉旁绒毛膜视网膜萎缩:额筛黏液囊肿患者的偶然发现
Pub Date : 2023-01-01 DOI: 10.4103/njvd.njvd_1_23
Y. Babalola, A. Ibiyemi
A 56-year-old Nigerian male patient presented to the eye clinic with a six-month history of progressive deterioration of vision in the right eye which was preceded by a one-month history of swelling above the right eye. He had no visual complaints in the left eye and no concurrent systemic illnesses. The best corrected visual acuity was hand movement with accurate light projection in the right eye and 6/6 in the left eye. On ocular examination, a right proptosis with inferotemporal displacement was present. A right relative afferent pupillary defect was noted while the left anterior segment examination was normal. Binocular indirect ophthalmoscopy of the right eye revealed a cup-to-disc ratio of 0.6, temporal disc pallor, peripapillary atrophy, and clumps of pigmentation along the venous arcades with generalized chorioretinal atrophy involving the area of the fovea. The cup-to-disc ratio was 0.4 with mild temporal disc pallor and iridescent spots at the macula with similar features of bony spicule-like clumps in the right eye present along the superotemporal arcade in the left eye. Optical coherence tomography (OCT) scan revealed disorganization of the inner retinal layers with intraretinal reflective foci with back-shadowing and both retinal pigment epithelium and choroidal atrophy. The OCT of the left eye showed a few intraretinal reflective foci and retinal pigment epithelium and choroidal atrophy. From the clinical and OCT findings, a diagnosis of pigmented paravenous chorioretinal atrophy and right fronto-ethmoidal mucocele is made.
一名56岁尼日利亚男性患者就诊于眼科诊所,右眼视力进行性恶化6个月,右眼上方肿胀1个月。他没有左眼视力不适,也没有并发的全身性疾病。最佳矫正视力为手部运动,右眼光投射准确,左眼6/6。眼部检查发现右眼突出伴颞下移位。左侧前段检查正常,右侧瞳孔相对传入缺损。右眼间接眼底镜检查显示杯盘比为0.6,颞盘苍白,乳头周围萎缩,静脉拱廊有色素团块沉积,伴广泛性绒毛膜视网膜萎缩,累及中央窝区域。杯盘比为0.4,颞盘轻度苍白,左眼沿颞上拱廊出现与右眼骨针状团块特征相似的黄斑彩虹状斑点。光学相干断层扫描(OCT)显示视网膜内层紊乱,视网膜内反射灶伴背影,视网膜色素上皮和脉络膜萎缩。左眼OCT显示视网膜内少量反射灶,视网膜色素上皮及脉络膜萎缩。根据临床及OCT表现,诊断为色素性静脉旁绒毛膜视网膜萎缩及右侧额筛黏液囊肿。
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引用次数: 0
Vascular endothelial growth factor inhibitors (anti-VEGF) use in Nigeria: The way forward 血管内皮生长因子抑制剂(anti-VEGF)在尼日利亚的应用前景
Pub Date : 2022-07-01 DOI: 10.4103/njvd.njvd_10_22
S. Nwosu
Intraocular neovascularization is a serious, blinding complication of diverse ischemic retinal vascular disorders. The treatment includes the use of vascular endothelial growth factors inhibitors (anti-VEGF), which are administered via intraocular injections. The commonly used anti-VEGF include bevacizumab, ranibizumab, and aflibercept. Although ranibizumab and aflibercept are approved for intraocular application, bevacizumab is used “off-label.” This article reviews the advantages and drawbacks of the anti-VEGF use and the implications for Nigeria where eye diseases requiring anti-VEGF treatment are also prevalent.
眼内新生血管是多种缺血性视网膜血管疾病的严重致盲并发症。治疗包括使用血管内皮生长因子抑制剂(抗vegf),通过眼内注射给药。常用的抗vegf药物包括贝伐单抗、雷尼单抗和阿非利塞普。虽然雷尼单抗和阿非利塞普被批准用于眼内应用,但贝伐单抗是“标签外”使用的。这篇文章回顾了抗vegf使用的优点和缺点以及对尼日利亚的影响,在尼日利亚需要抗vegf治疗的眼病也很普遍。
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引用次数: 0
Leber’s miliary aneurysm in an Asian woman: A case report 亚洲女性利伯氏军事动脉瘤一例报告
Pub Date : 2022-07-01 DOI: 10.4103/njvd.njvd_12_22
Osayem Otabor-Olubor, LO Ekechukwu
Leber miliary aneurysm is a part of the primary retinal telangiectasia spectrum. It usually presents in middle-aged males with retinal hard exudates and aneurysmal changes of the retinal vessels. It is often unilateral, and typically affects the temporal aspect of the retina. Treatment is with light laser photocoagulation and cryotherapy. We present a case of a 33-year-old Bangladeshi female who presented with gradual blurring of vision, with hard exudates and retinal vessel aneurysm and dilatation seen on her temporal retina. The temporal aspect of the macula was also involved.
利伯氏军事动脉瘤是原发性视网膜毛细血管扩张谱的一部分。它通常出现在中年男性视网膜硬渗出物和视网膜血管的动脉瘤样改变。它通常是单侧的,通常影响视网膜的颞部。治疗方法为激光、光凝和冷冻治疗。我们报告一例33岁的孟加拉女性,她表现为视力逐渐模糊,有硬渗出物,视网膜血管动脉瘤和颞视网膜扩张。黄斑的颞部也受到影响。
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引用次数: 0
Unilateral foveolitis, hyperhomocysteinemia, and dengue fever 单侧中心静脉炎,高同型半胱氨酸血症和登革热
Pub Date : 2022-07-01 DOI: 10.4103/njvd.njvd_9_22
P. Mahendradas, S. Sanjay, Aditya Dilipkumar Patil, P. Srinivasan
We describe a unique case of post-dengue fever (DF) central retinal vein occlusion (CRVO) with foveolitis and concomitant hyperhomocystinemia. A 21-year-old Asian Indian woman presented with a sudden decrease in vision in left eye (OS) 3 days after fever. Clinically she had impending CRVO with foveolitis in OS. Serology for dengue immunoglobulin G was positive (65.74) and serum homocysteine level was elevated (>50). Spectral-domain optical coherence tomography revealed posterior vitreous cells, altered foveal contour, a well-defined area of hyperreflectivity in the subfoveal region with disruption of outer nuclear layer, and external limiting membrane with subretinal fluid with intact retinal pigment epithelium suggestive of the foveolitis, most commonly described in DF. She was treated with systemic steroids and folic acid, with complete resolution of her clinical signs after 6 weeks. In addition to the hematological workup, history of fever DF should be considered as a possible etiology in a case of vein occlusion
我们描述了一个独特的病例后登革热(DF)视网膜中央静脉闭塞(CRVO)与中心静脉炎和伴随高同型半胱氨酸血症。一位21岁的亚洲印度女性在发烧3天后出现左眼视力突然下降。临床上,她有即将发生的CRVO伴中心静脉炎。血清登革免疫球蛋白G阳性(65.74),血清同型半胱氨酸水平升高(>50)。光谱域光学相干断层扫描显示后玻璃体细胞,中央凹轮廓改变,中央凹下区明显的高反射率区,外核层破坏,外限制膜有视网膜下液,视网膜色素上皮完整,提示中央凹炎,最常描述为DF。患者接受全身类固醇和叶酸治疗,6周后临床症状完全消失。除血液学检查外,在静脉闭塞病例中,发热DF史应被视为可能的病因
{"title":"Unilateral foveolitis, hyperhomocysteinemia, and dengue fever","authors":"P. Mahendradas, S. Sanjay, Aditya Dilipkumar Patil, P. Srinivasan","doi":"10.4103/njvd.njvd_9_22","DOIUrl":"https://doi.org/10.4103/njvd.njvd_9_22","url":null,"abstract":"We describe a unique case of post-dengue fever (DF) central retinal vein occlusion (CRVO) with foveolitis and concomitant hyperhomocystinemia. A 21-year-old Asian Indian woman presented with a sudden decrease in vision in left eye (OS) 3 days after fever. Clinically she had impending CRVO with foveolitis in OS. Serology for dengue immunoglobulin G was positive (65.74) and serum homocysteine level was elevated (>50). Spectral-domain optical coherence tomography revealed posterior vitreous cells, altered foveal contour, a well-defined area of hyperreflectivity in the subfoveal region with disruption of outer nuclear layer, and external limiting membrane with subretinal fluid with intact retinal pigment epithelium suggestive of the foveolitis, most commonly described in DF. She was treated with systemic steroids and folic acid, with complete resolution of her clinical signs after 6 weeks. In addition to the hematological workup, history of fever DF should be considered as a possible etiology in a case of vein occlusion","PeriodicalId":433701,"journal":{"name":"Nigerian Journal of Vitreoretinal Diseases","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134255261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central serous chorioretinopathy following ingestion of sympathomimetics: A case report from Abuja, Nigeria 服用拟交感神经药物后的中枢性浆液性脉络膜视网膜病变:尼日利亚阿布贾1例报告
Pub Date : 2022-07-01 DOI: 10.4103/njvd.njvd_14_22
Nurat Adeleye, Chidinma Ohuabunwa, A. Okudo, Aisha Abubakar
Central serous chorioretinopathy (CSCR) manifests mainly with the buildup of fluids beneath the retina often leading to distorted vision. This case report describes a patient with CSCR. A 34-year-old man presented to the eye clinic in October 2019 with complaints of blurry vision and metamorphopsia, which got worsened after 5 months of no treatment. The patient had a history of intake of a mixture containing phenylephrine, pseudoephedrine, and ephedrine over a period of 3 years for recurrent cold. Upon examination, his visual acuity was RE 6/9 LE 6/7.5 and his left macula was seen having a round serous detachment with creamy-white subretinal deposits. Optical coherence tomography revealed a retinal thickness of 360.5 ± 94.7 µm and macular edema. He was treated with intravitreal ranibizumab and cessation of sympathomimetic drugs with a modest visual improvement achieved within a month. There has been no reoccurrence over the 2-year period he was followed up. There could be an association between chronic ingestion of sympathomimetics and the risk of developing CSCR.
中枢性浆液性脉络膜视网膜病变(CSCR)主要表现为视网膜下积液,常导致视力扭曲。本病例报告描述了一例CSCR患者。一名34岁男子于2019年10月到眼科诊所就诊,主诉视力模糊和变形,未经治疗5个月后病情恶化。患者曾因复发性感冒服用含苯肾上腺素、伪麻黄碱和麻黄碱的混合物3年。检查视力为RE 6/9 LE 6/7.5,左侧黄斑可见圆形浆液性脱离,视网膜下有乳白色沉积物。光学相干断层扫描显示视网膜厚度360.5±94.7µm,黄斑水肿。患者接受玻璃体内注射雷尼单抗和停止使用拟交感神经药物治疗,一个月内视力略有改善。随访2年无复发。慢性摄入拟交感神经制剂与发生CSCR的风险之间可能存在关联。
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引用次数: 0
Valsalva retinopathy in Nigerians: A case series 尼日利亚Valsalva视网膜病变:一个病例系列
Pub Date : 2022-07-01 DOI: 10.4103/njvd.njvd_15_22
T. Akanbi, O. Oderinlo
Valsalva retinopathy is considered rare. Patients present with sudden visual loss due to premacular hemorrhage. Treatment depends on the presentation. Three patients presented to us between 2013 and 2022 with sudden visual loss caused by Valsalva retinopathy. Case 1 was a 26-year-old female primigravida with right premacular hemorrhage after severe vomiting which was treated with pneumatic displacement with air. Case 2 was a 23-year-old male with left premacular hemorrhage. He had no memory of a Valsalva maneuver. He had vitrectomy for premacular dehemoglobinized non-resolving hemorrhage. Case 3 was a 27-year-old pregnant female with left premacular hemorrhage after vomiting. She was managed conservatively. Large, dense, or non-resolving hemorrhages require treatment while small hemorrhages may spontaneously resolve. The patients had different treatment strategies with good outcomes
Valsalva视网膜病变被认为是罕见的。患者表现为黄斑前出血引起的突发性视力丧失。治疗取决于表现。2013年至2022年间,有3例患者因Valsalva视网膜病变导致突发性视力丧失。病例1是一名26岁的女性初产妇,因严重呕吐后右侧黄斑前出血,经充气置换治疗。病例2为23岁男性,左侧黄斑前出血。他不记得瓦尔萨尔瓦的战术。因黄斑前脱血红蛋白性不溶性出血行玻璃体切除术。病例3为27岁孕妇,呕吐后左侧黄斑前出血。她被管理得很保守。大的、致密的或不能溶解的出血需要治疗,而小的出血可以自行溶解。患者采用不同的治疗策略,均取得良好的效果
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引用次数: 1
Outcome of retropupillary Iris claw lens implantation at Lagos State University Teaching Hospital 拉各斯州立大学教学医院瞳孔后虹膜爪形人工晶状体植入术的疗效
Pub Date : 2022-07-01 DOI: 10.4103/njvd.njvd_13_22
Idris Saka, M. Balogun, B. Adekoya, B. Balogun, C. Ekumankama, Ro Ngwu, M. Fashola, Ufoma Olumodeji
Introduction: Cataract surgery with intraocular lens (IOL) implantation is one of the most common intraocular surgeries performed in the Department of Ophthalmology of the Lagos State University Teaching Hospital (LASUTH). Failure to implant an IOL in the posterior chamber can result in a compromised posterior capsule because of rupture or weak zonular support. Iris claw lens (ICL) implantation posterior to the iris (retropupillary) allows for posterior chamber implantation in the absence of adequate capsular support. Objectives: To assess the immediate and short-term outcomes of retropulillary ICL implantation as well as the immediate and short-term complications in patients at the LASUTH. Materials and Methods: A retrospective analysis of all patient case notes seen from January 2022 to November 2022 at the Ophthalmology department of LASUTH who met the inclusion criteria and had ICL implantation were collected and assessed. Patient’s demographic data, indication for ICL implantation, visual status preoperatively, postoperatively, and complications were analyzed. Results: A total of 20 eyes of 20 patients had the procedure in the study period. The age range was 12–70 and the longest follow-up period was 7 months with the shortest being 3 weeks. The mean preoperative visual acuity was 3/60, and the mean postoperative best-corrected distant visual acuity was 6/12. Immediate postoperative complications were uveitis (23%), raised IOP (5%), hypotony (10%), vitreous inflammation (13%), and cornea edema (13%). Conclusion: Retropupillary ICL implantation carries a good postoperative visual outcome; it is encouraged that this procedure is considered as an alternative to both anterior chamber IOL and scleral fixated IOL.
导读:白内障手术联合人工晶状体植入术是拉各斯州立大学教学医院眼科最常见的眼内手术之一。在后房区植入人工晶状体失败可能会导致后囊膜破裂或弱带状支撑而受损。虹膜爪晶状体(ICL)植入虹膜后(瞳孔后)允许在没有足够的囊支持的情况下植入后房室。目的:评价LASUTH患者行肱骨后ICL植入术的近期和近期疗效及近期和近期并发症。材料与方法:回顾性分析2022年1月至2022年11月LASUTH眼科所有符合纳入标准并植入ICL的病例记录。分析患者的人口学资料、ICL植入术指征、术前、术后视力状况及并发症。结果:20例患者共20只眼在研究期间进行了手术。年龄12 ~ 70岁,最长随访7个月,最短随访3周。术前平均视力为3/60,术后最佳矫正远视平均视力为6/12。术后即刻并发症为葡萄膜炎(23%)、IOP升高(5%)、低眼压(10%)、玻璃体炎症(13%)和角膜水肿(13%)。结论:瞳孔后ICL植入术术后视力良好;值得鼓励的是,该手术被认为是前房人工晶状体和巩膜固定人工晶状体的替代方法。
{"title":"Outcome of retropupillary Iris claw lens implantation at Lagos State University Teaching Hospital","authors":"Idris Saka, M. Balogun, B. Adekoya, B. Balogun, C. Ekumankama, Ro Ngwu, M. Fashola, Ufoma Olumodeji","doi":"10.4103/njvd.njvd_13_22","DOIUrl":"https://doi.org/10.4103/njvd.njvd_13_22","url":null,"abstract":"Introduction: Cataract surgery with intraocular lens (IOL) implantation is one of the most common intraocular surgeries performed in the Department of Ophthalmology of the Lagos State University Teaching Hospital (LASUTH). Failure to implant an IOL in the posterior chamber can result in a compromised posterior capsule because of rupture or weak zonular support. Iris claw lens (ICL) implantation posterior to the iris (retropupillary) allows for posterior chamber implantation in the absence of adequate capsular support. Objectives: To assess the immediate and short-term outcomes of retropulillary ICL implantation as well as the immediate and short-term complications in patients at the LASUTH. Materials and Methods: A retrospective analysis of all patient case notes seen from January 2022 to November 2022 at the Ophthalmology department of LASUTH who met the inclusion criteria and had ICL implantation were collected and assessed. Patient’s demographic data, indication for ICL implantation, visual status preoperatively, postoperatively, and complications were analyzed. Results: A total of 20 eyes of 20 patients had the procedure in the study period. The age range was 12–70 and the longest follow-up period was 7 months with the shortest being 3 weeks. The mean preoperative visual acuity was 3/60, and the mean postoperative best-corrected distant visual acuity was 6/12. Immediate postoperative complications were uveitis (23%), raised IOP (5%), hypotony (10%), vitreous inflammation (13%), and cornea edema (13%). Conclusion: Retropupillary ICL implantation carries a good postoperative visual outcome; it is encouraged that this procedure is considered as an alternative to both anterior chamber IOL and scleral fixated IOL.","PeriodicalId":433701,"journal":{"name":"Nigerian Journal of Vitreoretinal Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125793883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Nigerian Journal of Vitreoretinal Diseases
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