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The pharmacological deprescription in elderly patients 老年患者的药物处方
IF 0.4 Q3 Medicine Pub Date : 2023-12-19 DOI: 10.4081/itjm.2023.1676
Chelsey Ali, Daniel Huang, Charlene Tugwete, Stefano Del Canale, Vittorio Maio
N/A
不适用
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引用次数: 0
Linea Guida Multisocietaria per il paziente adulto con diabete o con iperglicemia ricoverato in setting clinico non critico 非危重临床环境中收治的成年糖尿病或高血糖患者的多协会指南
IF 0.4 Q3 Medicine Pub Date : 2023-12-19 DOI: 10.4081/itjm.q.2023.4
R. Pastorelli, A. Maffettone, M. Nizzoli, G. Bordin
IntroduzioneGruppo di sviluppo della Linea GuidaCaratteristiche di una Linea Guida dell’ISS pubblicata sul Sito Nazionale Linee GuidaElenco dei quesitiQuesito 1: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 2: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 3: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 4: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 5: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 6: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 7: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 8: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 9: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 10: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 11: premesse, sintesi delle evidenze, raccomandazione, commentoQuesito 12: premesse, sintesi delle evidenze, raccomandazione, commentoDiscussioneConclusioni
导言指南制定小组在国家指南网站上发布的 ISS 指南的特点问题列表第 1 题:导言、证据摘要、建议、评论第 2 题:导言、证据摘要、建议、评论第 3 题:导言、证据摘要、建议、评论第 4 题:导言、证据摘要、建议、评论第 5 题:导言、证据摘要、建议、评论第 6 题主题 7:前提、证据摘要、建议、评论主题 8:前提、证据摘要、建议、评论主题 9:前提、证据摘要、建议、评论主题 10:前提、证据摘要、建议、评论主题 11:前提、证据摘要、建议、评论主题 12:前提、证据摘要、建议、评论讨论结论
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引用次数: 0
The 2023 hypertension guidelines of the European Society of Hypertension: a commentary 欧洲高血压学会 2023 年高血压指南:评述
IF 0.4 Q3 Medicine Pub Date : 2023-12-19 DOI: 10.4081/itjm.2023.1675
G. Mancia, Guido Grassi, Enrico Agabiti-Rosei, Claudio Borghi, M. Muiesan, Paolo Palatini, Gianfranco Parati, Stefano Taddei, Reinhold Kreutz
N/A
不适用
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引用次数: 0
COVID-19 effects on mental health of children and adolescents with intellectual disabilities in North Kosovo COVID-19 对科索沃北部智障儿童和青少年心理健康的影响
IF 0.4 Q3 Medicine Pub Date : 2023-12-04 DOI: 10.4081/itjm.2023.1667
Snežana R. Markovic-Jovanovic, Aleksandar N. Jovanovic, Marina Petrovic, Dragoslava Ristic, Gordana Dželetović, Ana Karanovic, Dejan Tabakovic, Danijela Jovanovic
Background. People with intellectual disabilities (ID) are susceptible to physical, mental and social implications of the COVID-19 pandemic. Aim. Learning the way young individuals with disabilities dealt with the COVID-19 pandemic and how it affected their lives. Materials and Methods. An epidemiological questionnaire including information on the person’s health, mental state, behavior, educational capabilities, and epidemiological and clinical features of the COVID-19 infection was completed by 41 children/young adults and their family members. Results. During the two-year period of the pandemic, we monitored the frequency of COVID-19 infection in children and adolescents with intellectual disorders, children’s mental condition, and the occurrence of post-COVID symptoms. We also discussed the role of society regarding economic stability and support for families with a disabled member. Conclusions. The severity of COVID-19 symptoms was the independent predictor of mental status deterioration. Children and adolescents with ID experienced a greater prevalence of COVID-19 infection as well as post-COVID sequelae.
背景。智障人士很容易受到COVID-19大流行对身体、精神和社会的影响。的目标。了解残疾青年如何应对2019冠状病毒病疫情,以及疫情如何影响他们的生活。材料与方法。对41名儿童/青年及其家庭成员填写流行病学问卷,内容包括个人健康状况、精神状态、行为、教育能力、新冠肺炎感染的流行病学和临床特征等。结果。在两年的大流行期间,我们监测了患有智力障碍的儿童和青少年的COVID-19感染频率、儿童精神状况以及COVID-19后症状的发生情况。我们还讨论了社会在经济稳定和支持有残疾成员的家庭方面的作用。结论。COVID-19症状严重程度是精神状态恶化的独立预测因子。患有ID的儿童和青少年感染COVID-19的患病率更高,并且出现了COVID-19后的后遗症。
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引用次数: 0
Lung damages of malaria: a differential diagnosis and treatment in emergency room of a rare case 疟疾引起的肺损伤:一例罕见病例的鉴别诊断和急诊治疗
IF 0.4 Q3 Medicine Pub Date : 2023-11-29 DOI: 10.4081/itjm.2023.1603
N. Carannante, S. Scarica, Raffaele Disarno, Gerardo Langella, P. Di Micco, G. Fiorentino
Pulmonary involvement occurs in 3 to 10% of the cases of Plasmodium falciparum malaria and represents the most severe complication of this infection, with a lethality of about 70%. The antigens released by the parasite play an important role in the induction and worsening of lung damage. Capillary endothelial cells, which control the flux of fluids to the interstitial space, appear to be the most complicated structures. The clinical manifestations of pulmonary involvement may start suddenly at any time during the course of malaria, even after the disappearance of the circulating parasite. Hyperparasitemia predisposes to these factors. Treatment with corticosteroids is optional, and that is not often a benefit.
在恶性疟原虫疟疾病例中,肺部受累的比例为 3%至 10%,是这种感染最严重的并发症,致死率约为 70%。寄生虫释放的抗原在诱发和加重肺损伤方面起着重要作用。毛细血管内皮细胞控制着体液向间质的流动,似乎是最复杂的结构。肺部受累的临床表现可能在疟疾病程的任何时候突然开始,甚至在循环寄生虫消失后也是如此。高寄生虫血症容易导致这些因素。皮质类固醇的治疗是可选的,但通常并无益处。
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引用次数: 0
STAT3 eye-opener in COVID-19 STAT3 在 COVID-19 中大放异彩
IF 0.4 Q3 Medicine Pub Date : 2023-11-28 DOI: 10.4081/itjm.2023.1650
C. Mozzini, Giuseppe Lucchini, Mauro Pagani
Among the elevated inflammatory mediators, blood Interleukin-6 (IL-6) level is highly correlated with COVID-19 mortality and predicts the need for mechanical ventilation. IL-6 is the major activator of signal transducers and activators of transcription-3 (STAT3) during inflammatory responses. The primary objective of the study is to explore STAT3 activation in different subsets of circulating cells derived from 25 COVID-19 patients (patients) admitted to an Internal Medicine department compared to 25 healthy donors (HD). Higher percentages of classical and intermediate monocytes were observed in patients, compared to HD (respectively P<0.01 and P<0.001). The active form of STAT3, phosphorylated STAT3 (pSTAT3) was significantly higher in patients, compared to HD, both in non-classical and in intermediate monocytes (P<0.001). Low-density neutrophils (LDN) count was significantly higher in patients compared to HD (P<0.001). The pSTAT3 was significantly higher in LDN derived from patients (P<0.05). High pSTAT3 was significantly directly related to d-dimer and inversely related to vitamin D levels (P<0.01). This study gives information about STAT3 activation and the possible role of Vitamin D as a tool against COVID-19.
在升高的炎症介质中,血液白细胞介素-6(IL-6)水平与 COVID-19 死亡率高度相关,并可预测是否需要机械通气。IL-6 是炎症反应过程中信号转导和转录激活因子-3(STAT3)的主要激活因子。本研究的主要目的是探讨与 25 名健康捐献者(HD)相比,25 名内科收治的 COVID-19 患者(患者)循环细胞中不同亚群的 STAT3 激活情况。与健康捐献者相比,患者体内典型单核细胞和中间单核细胞的比例更高(分别为 P<0.01 和 P<0.001)。与 HD 相比,患者非典型单核细胞和中间型单核细胞中 STAT3 的活性形式--磷酸化 STAT3(pSTAT3)明显更高(P<0.001)。与 HD 相比,患者的低密度中性粒细胞(LDN)数量明显增加(P<0.001)。来自患者的低密度中性粒细胞的 pSTAT3 明显更高(P<0.05)。高 pSTAT3 与 d-二聚体明显直接相关,与维生素 D 水平成反比(P<0.01)。这项研究提供了有关 STAT3 激活的信息,以及维生素 D 作为抗击 COVID-19 的工具可能发挥的作用。
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引用次数: 0
Prolonged prothrombin time in a rare case of vitamin K deficiency: a case report and a narrative review 一例罕见的维生素 K 缺乏症患者凝血酶原时间延长:病例报告和综述
IF 0.4 Q3 Medicine Pub Date : 2023-11-21 DOI: 10.4081/itjm.2023.1665
Matteo Nicoletto, Eleonora Galli, Alice Cerato, Cristina Olivero, Francisca Bulai, Irene Praticò, Fulvio Pomero
Prolonged prothrombin time increases the risk of bleeding complications in proportion to prolongation severity. We reported the case of a 72-year-old woman with a recent hospitalization for methicillin-susceptible Staphylococcus aureus endocarditis complicated by spondylodiscitis who developed a severe prolongation of clotting time during treatment with cefazolin due to a vitamin K deficiency. Cefazolin is a first-generation cephalosporin active against gram-positive bacteria. Like other cephalosporins, it is potentially able to inhibit the enzymes involved in recycling vitamin K metabolites, leading to a fall in gamma-carboxylation of vitamin K-dependent clotting factors. Clinicians should be aware of the necessity of regular monitoring of clotting times for the duration of antimicrobial therapy, especially in those patients with several risk factors for a poor vitamin K nutritional status. Prompt detection of vitamin K deficiency should be recognized and adequately supplemented.
凝血酶原时间延长会增加出血并发症的风险,与延长的严重程度成正比。我们报告了一例 72 岁女性患者的病例,该患者近期因甲氧西林易感金黄色葡萄球菌心内膜炎并发脊柱盘炎症住院治疗,在使用头孢唑啉治疗期间因维生素 K 缺乏导致凝血时间严重延长。头孢唑啉是第一代头孢菌素,对革兰氏阳性菌具有活性。与其他头孢菌素一样,它可能会抑制参与维生素 K 代谢物循环的酶,导致依赖维生素 K 的凝血因子的γ-羧化作用下降。临床医生应认识到,在抗菌药物治疗期间定期监测凝血时间的必要性,尤其是对那些存在多种维生素 K 营养状况不良风险因素的患者。应及时发现维生素 K 缺乏症并给予适当补充。
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引用次数: 0
How artificial intelligence during the pandemic modified the role of a biomarker as d-dimer 大流行病期间的人工智能如何改变生物标记物 d-二聚体的作用
IF 0.4 Q3 Medicine Pub Date : 2023-11-20 DOI: 10.4081/itjm.2023.1656
P. Di Micco, F. F. Bernardi, Giovanni Maria Fusco, Alessandro Perrella
Artificial intelligence (AI) was introduced in medicine to make some difficult decision-making regarding diagnostics and/or treatments easy. Its application derives from the improvement of information obtained with computer sciences and informatics, in particular with information derived by algorithms obtained with special informatics support as machine learning. The scenario of hospital changes induced by the COVID-19 pandemic makes easy the application of AI for some clinical updates. Being lung failure with pulmonary embolism is the most common cause of death for inpatients with COVID-19, some biomarkers such as the d-dimer are constantly used associated with other clinical features in order to improve medical assistance. For this reason, d-dimer during the pandemic changed its traditional use for predictive negative value in patients with suspected pulmonary embolism and took relevance for its values giving the chance to change the intensity of anticoagulation for several inpatients. In most cases, according to data reported from several cohorts, these changes improved the morbidity and mortality of a significant percentage of inpatients with COVID-19. The International medical prevention registry on venous thromboembolism and d-dimer and modified sepsis-induced coagulopathy scores were the most used scores derived from AI and dedicated to these clinical aspects in inpatients with COVID-19. Therefore, this review was dedicated to flexible changes that we can use after d-dimer values in different clinical scenarios that vary from disseminated intravascular coagulation to pulmonary embolism to COVID-19.
人工智能(AI)被引入医学领域,使诊断和/或治疗方面的一些困难决策变得容易。人工智能的应用源于计算机科学和信息学对信息的改进,特别是通过特殊信息学支持(如机器学习)获得的算法所产生的信息。由 COVID-19 大流行病引发的医院变化使人工智能在某些临床更新中的应用变得容易。由于肺功能衰竭和肺栓塞是 COVID-19 住院病人最常见的死亡原因,一些生物标志物(如 d-二聚体)经常与其他临床特征结合使用,以改善医疗援助。因此,在大流行期间,d-二聚体改变了其在肺栓塞疑似患者中预测阴性值的传统用途,其数值的相关性使一些住院患者有机会改变抗凝治疗的强度。在大多数情况下,根据几个队列报告的数据,这些变化改善了 COVID-19 住院病人中很大一部分人的发病率和死亡率。静脉血栓栓塞症国际医疗预防登记、d-二聚体和改良脓毒症诱发凝血病评分是最常用的评分,这些评分来自人工智能,专门针对 COVID-19 住院患者的这些临床方面。因此,本综述专门讨论了在不同的临床情况下(从弥散性血管内凝血到肺栓塞再到 COVID-19)d-二聚体值后我们可以使用的灵活变化。
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引用次数: 0
Correlation between extended surgical mask usage and adverse health effects during the COVID-19 pandemic among healthcare personnel in Jazan, Saudi Arabia 沙特阿拉伯贾赞医护人员在 COVID-19 大流行期间延长外科口罩使用时间与不良健康影响之间的相关性
IF 0.4 Q3 Medicine Pub Date : 2023-11-20 DOI: 10.4081/itjm.2023.1636
Suhaila A. Ali, Ahmad Y. Alqassim, Fatmah O. Alshekh, Atheer M. Alshammakhi, Rawan N. Omar, Roaa A. Areeshi, Roaa Alhazmi, Lamees A. Zaalah, Mohammed A. Muaddi, Abdullah A. Alharbi
The global prevalence of COVID-19 has necessitated the use of personal protective equipment, particularly face masks, amongst healthcare workers (HCWs). However, extended face mask usage has led to adverse health effects. This cross-sectional study investigates the relationship between prolonged surgical mask-wearing and the development of adverse effects among 500 HCWs in Jazan, Saudi Arabia. The study utilized an anonymous questionnaire distributed across multiple departments in Jazan and Sabya Hospitals. The results indicated that most participants believed that wearing face masks for extended periods led to adverse skin and respiratory effects. The primary respiratory complaints were difficulty breathing and nasal itching, while skin-related issues included sweating, itching, and acne. Therefore, this study concludes that extended surgical mask usage during the COVID-19 pandemic could potentially lead to adverse health implications among HCWs in Jazan. Further research into this correlation is needed.
COVID-19 在全球的流行使得医护人员(HCWs)必须使用个人防护设备,尤其是口罩。然而,长时间使用口罩会对健康造成不良影响。这项横断面研究调查了沙特阿拉伯贾赞市 500 名医护人员长期佩戴外科口罩与不良反应之间的关系。研究采用匿名问卷调查的方式,在贾赞和萨比亚医院的多个部门发放。结果显示,大多数参与者认为长时间佩戴口罩会对皮肤和呼吸系统造成不良影响。主要的呼吸道问题是呼吸困难和鼻痒,而与皮肤相关的问题包括出汗、瘙痒和痤疮。因此,本研究得出结论,在 COVID-19 大流行期间长时间使用外科口罩可能会对贾赞的高危行业工人的健康造成不良影响。需要对这种相关性进行进一步研究。
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引用次数: 0
Healthy diet, prevalence and factors associated among adults of Nekemte dwellers, Oromia State, Western Ethiopia 埃塞俄比亚西部奥罗米亚州 Nekemte 居民中的健康饮食、流行率及相关因素
IF 0.4 Q3 Medicine Pub Date : 2023-11-20 DOI: 10.4081/itjm.2023.1630
Alemu Adeba, Dessalegn Tamiru, T. Belachew
Introduction. Adaption and adoption of a healthy lifestyle remain challenging worldwide. An unhealthy diet is the core risk of lifestyle illnesses. However, the status of a healthy diet and its predictors were not assessed in Nekemte town targeting middle-aged adulthoods. The study was designed to assess healthy diet, prevalence and factors associated among middle-aged adults in Nekemte town from January 15, 2019, to February 30, 2019. Materials and Methods. A descriptive epidemiological study design typically cross-sectional analysis was applied in Nekemte town on middle-aged adults. Primary data was gathered by using a questionnaire and checked for its normality. Factors associated with dependent variables were analyzed with logistic regressions and their significance was determined at P<0.05. Results. The status of dieting practice was 73.31% (unhealthy) and 26.69% (healthy), respectively. This study showed that being low income (P=0.001), not married (P=0.001), and daily meal frequency [adjusted odds ratio (AOR): 1.91, 95% confidence interval (CI): [1.04, 2.71]) are associated with unhealthy diets. The odds of having an unhealthy diet were almost 3 times (AOR=3.20, [95% CI: (2.04, 5.98) higher for illiterate compared to literate participants. In addition, an unhealthy diet was nearly 5 times (AOR: 4.87, 95% CI: [3.23, 7.65]) higher for having poor knowledge of healthy diet compared to alert participants. Conclusions. The researchers identified unhealthy diets practiced highly by the study samples of the populations.
导言在全球范围内,适应和采用健康的生活方式仍然是一项挑战。不健康的饮食是生活方式疾病的核心风险。然而,在 Nekemte 镇,针对中年人的健康饮食状况及其预测因素尚未得到评估。本研究旨在评估 2019 年 1 月 15 日至 2019 年 2 月 30 日期间内肯特镇中年人的健康饮食、流行率及其相关因素。材料与方法。本研究采用描述性流行病学研究设计,对 Nekemte 镇的中年人进行了典型的横断面分析。使用问卷收集原始数据,并检查其正态性。与因变量相关的因素通过逻辑回归进行分析,其显著性以 P<0.05 为标准。结果显示饮食习惯状况分别为 73.31%(不健康)和 26.69%(健康)。研究表明,低收入(P=0.001)、未婚(P=0.001)和每日进餐次数[调整后的几率比(AOR):1.91,95% 置信区间(CI):[1.04, 2.71]]与不健康饮食有关。与识字参与者相比,文盲参与者的不健康饮食几率几乎高出三倍(AOR=3.20,[95% 置信区间:(2.04,5.98))。此外,对健康饮食知之甚少的参与者的不健康饮食几率是警觉参与者的近 5 倍(AOR:4.87,95% CI:[3.23, 7.65])。结论研究人员发现,不健康饮食在研究样本人群中非常普遍。
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引用次数: 0
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Italian Journal of Medicine
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