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A rare cause of recurrent syncope: chemodectoma of left carotid 复发性晕厥的罕见病因:左颈动脉化学瘤
IF 0.4 Q3 Medicine Pub Date : 2023-05-31 DOI: 10.4081/itjm.2023.1585
Claudia Arturo, L. D'Alessandro, M. R. Poggiano, G. Orefice, Antonietta Longobardo, M. Liguori, C. Arcamone, A. Di Scala, Ciro di Gennaro, P. Di Micco
Syncope is a frequent cause of access to emergency departments. Recurrent syncope may be associated with a transient lock of consciousness. When neurological or cardiological common causes of syncope are excluded, rare causes of syncope, such as solid carotid tumors, should be considered. In this study, we report a rare case of left carotid chemodectoma in a patient with frequent access to the emergency room for syncope in which a thorough differential diagnosis has been performed.
晕厥是进入急诊室的常见原因。复发性晕厥可能伴有短暂的意识丧失。当排除神经性或心脏病性常见晕厥原因时,应考虑罕见的晕厥原因,如颈动脉实体瘤。在这项研究中,我们报告了一个罕见的左颈动脉化疗瘤患者频繁进入急诊室晕厥,并进行了彻底的鉴别诊断。
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引用次数: 0
Adult-onset Still’s disease with secondary macrophage activation syndrome: a case report 成人发病斯蒂尔氏病伴继发性巨噬细胞激活综合征1例报告
IF 0.4 Q3 Medicine Pub Date : 2023-05-29 DOI: 10.4081/itjm.2023.1595
G. Nicoletti, Antonio Bonelli, Rocco Clemente, Simona Ciuffreda, Gaetano Dentamaro, Agata Tiziana La Masa, Vito Lascaro, P. Santarcangelo
We describe a case of adult-onset Still’s disease (AOSD) with secondary macrophage activation syndrome. AOSD is a rare disease with unknown origin. Rarely it’s complicated by secondary macrophage activation syndrome, which is a life-threatening disorder. Because the diagnosis of AOSD is essential for exclusion and complications are life-threatening, it is mandatory for a prompt and extensive diagnostic workup and treatment.
我们描述了一例成人斯蒂尔病(AOSD)伴继发性巨噬细胞活化综合征的病例。AOSD是一种起源不明的罕见病。很少会并发继发性巨噬细胞活化综合征,这是一种危及生命的疾病。由于AOSD的诊断对于排除和并发症危及生命至关重要,因此必须进行及时和广泛的诊断检查和治疗。
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引用次数: 0
FADOI survey on chronic kidney disease and anaemia in internal medicine departments of Italian hospitals FADOI对意大利医院内科慢性肾脏疾病和贫血的调查
IF 0.4 Q3 Medicine Pub Date : 2023-05-29 DOI: 10.4081/itjm.2023.1605
P. Bocchi, A. Montagnani, Michele Meschi, F. Pomero, P. Piccolo, A. Valerio, G. Gussoni, D. Manfellotto, F. Dentali, Chronic Kidney Disease and Anaemia In Internal Medicine (CKD-AIM) FADOI Study Group
The presence of anaemia in patients with chronic kidney disease (CKD) is associated with decreased quality of life, along with increased morbidity, mortality, and hospitalization rates. This, in turn, affects healthcare costs and the utilization of medical resources. The mechanisms involved in anaemia of CKD are diverse and complex. They include reduced production of endogenous erythropoietin (EPO), absolute and/or functional iron deficiency (due to inflammation leading to elevated levels of hepcidin), the diminished response of the bone marrow to EPO due to uraemic toxins, the shortened lifespan of red blood cells (RBC), and deficiencies in vitamin B12 or folic acid. [...]
慢性肾脏病(CKD)患者贫血与生活质量下降以及发病率、死亡率和住院率增加有关。这反过来又影响了医疗成本和医疗资源的利用。CKD贫血的发病机制多种多样且复杂。它们包括内源性红细胞生成素(EPO)的产生减少、绝对和/或功能性缺铁(由于炎症导致铁调素水平升高)、尿毒症毒素导致骨髓对EPO的反应减弱、红细胞(RBC)寿命缩短以及维生素B12或叶酸缺乏。[…]
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引用次数: 0
Nattokinase historical sketch on experimental and clinical evidence 纳豆激酶实验和临床证据的历史概述
IF 0.4 Q3 Medicine Pub Date : 2023-05-16 DOI: 10.4081/itjm.2023.1583
P. Di Micco, F. F. Bernardi, G. Camporese, Mario Biglietto, A. Perrella, T. Ciarambino, V. Russo, E. Imbalzano
Nattokinase (NK) is a protease derived from food used mainly in the Japanese diet that has several properties. The main activity is related to improving fibrinolytic activities. Other activities have been demonstrated in the regulation of blood pressure by the action toward angiotensin proteases and in the antiplatelet activities. NK can be given orally and reaches its maximal concentration after 12 hours. In addition, an antithrombotic activity based on various NK activities has been proposed. First, increased fibrinolytic activity increases thrombus dissolution and/or the formation of atherosclerotic plaques; second, its enhanced antiplatelet action adds to clot dissolution. All activities have been studied in animals and humans in vitro and in vivo. Relevant adverse effects of NK therapy have not been described, however clinical experience is restricted to case series and volunteers and is not based on clinical studies, thus clinical trials are required to confirm.
纳豆激酶(NK)是一种蛋白酶,主要来源于日本饮食中使用的食物,具有几种特性。其主要作用与改善纤溶活性有关。其他活性已被证明是通过对血管紧张素蛋白酶的作用和抗血小板活性来调节血压。NK可口服,12小时后达到最大浓度。此外,已经提出了一种基于各种NK活性的抗血栓活性。首先,纤溶活性增加会增加血栓溶解和/或动脉粥样硬化斑块的形成;其次,其增强的抗血小板作用增加了血块的溶解。所有的活性都在动物和人类体内和体外进行了研究。NK治疗的相关不良反应尚未见报道,但临床经验仅限于病例系列和志愿者,并不是基于临床研究,需要临床试验来证实。
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引用次数: 0
Results of an observational retrospective multicenter study: “Campania INternal medicine - the Clinical INternist for heart failure” 一项观察性回顾性多中心研究的结果:“坎帕尼亚内科——心力衰竭的临床专家”
IF 0.4 Q3 Medicine Pub Date : 2023-05-08 DOI: 10.4081/itjm.2023.1594
F. Gallucci, Emiliana Marrone, Roberto Nappi, Maurizio Renis, M. Coppola, T. Ciarambino, Daniele D'Ambrosio, A. Maffettone, M. D’avino, Cin Cin For HF Group Researchers
Introduction. The Campania population is characterized by a high incidence and prevalence of heart failure (HF). The aim of this study is to describe the clinical epidemiology, comorbidities, and treatments in HF patients admitted to Internal Medicine Wards (IMW) in Campania. Materials and Methods. It is a retrospective, regional, multicentric, observational study including patients admitted to 15 IMW in Campania, with an HF diagnosis, over a period of three consecutive months. Results. We identified 427 patients, stratified by ejection fraction (EF) category (127 EF≤40%; 216 EF 41-49%; 84 EF≥50%). In comparison with HFpEF subjects, patients with HFrEF were younger (74 years vs. 9 years), more commonly male (67% vs. 32%), and more likely to have an ischaemic aetiology (45% vs. 25%). The most used drugs at the time of hospitalization and after were Diuretics (80.3/93.5%), BBs (69.6/92.6%), and Statins (52.1/63.7%), with statistically significant pre-/post- differences (P≤0.05). Conclusions. EF is more likely to be non-preserved in younger males and in patients with CAD etiology. Hospitalization influences in a statistically significant way the change or adjustment of therapy for almost all drugs.
介绍坎帕尼亚人群的特点是心力衰竭(HF)的发病率和患病率很高。本研究的目的是描述坎帕尼亚内科病房(IMW)HF患者的临床流行病学、合并症和治疗。材料和方法。这是一项回顾性、区域性、多中心的观察性研究,包括连续三个月在坎帕尼亚接受15次IMW诊断为HF的患者。后果我们确定了427名患者,按射血分数(EF)类别分层(127 EF≤40%;216 EF 41-49%;84 EF≥50%)。与HFpEF受试者相比,HFrEF患者更年轻(74岁对9岁),更常见的是男性(67%对32%),更有可能具有缺血性病因(45%对25%)。住院时和住院后使用最多的药物是利尿剂(80.3/93.5%)、BBs(69.6/92.6%)和他汀类药物(52.1/63.7%),前后差异具有统计学意义(P≤0.05)。EF在年轻男性和CAD病因患者中更有可能不被保留。住院以统计学上显著的方式影响几乎所有药物的治疗变化或调整。
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引用次数: 0
Abstract book of the XXVIII Congresso Nazionale della Società Scientifica FADOI, 6-8 maggio 2023 2023年5月6日至8日,法多伊科学学会第28届全国大会摘要书
IF 0.4 Q3 Medicine Pub Date : 2023-05-05 DOI: 10.4081/itjm.2023.s1
Fadoi Scientific Committee
Abstract book of the XXVIII Congresso Nazionale della Società Scientifica FADOI, 6-8 maggio 2023.
2023年5月6日至8日,法多伊科学学会第28届全国大会摘要书。
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引用次数: 0
The prevalence of anemia in patients with malignant tumors: a hospital based cross sectional study 恶性肿瘤患者贫血患病率:一项基于医院的横断面研究
IF 0.4 Q3 Medicine Pub Date : 2023-05-02 DOI: 10.4081/itjm.2023.1571
Dafalla O. Abuidris, O. Abdelbagi, Reem Altayeb, Hiba Elrashid Yagoub, Osama Al-Wutayd, I. Adam, M. Alorini
Cancer is a worldwide health problem, and anemia is one of its manifestations. There are no published data on anemia among patients with cancer in Sudan. The current study aimed to investigate the prevalence of anemia among patients with malignant tumors in central Sudan. The medical records of patients with malignant tumors admitted to the National Cancer Institute, University of Gezira, Sudan, from March to December 2020 were reviewed. Among the 471 patients enrolled in the study, 292 (62.0%) were female. The median (interquartile range, IQR) age was 55 (45-66) years. Breast cancer (109, 23.1%), colorectal/anorectal (88, 18.7%), head and neck (83, 17.6%), female genital tract (70, 14.9%), and prostate (35, 7.4%) cancer were the main cancers observed in this study. The median (IQR) hemoglobin was 11.9 (10.5-13.0) g/dl and 237 (50.3%) patients had anemia. The prevalence of anemia ranged from 31.2% in breast cancer patients to 82.9% in those with prostate cancer. Compared with males (120/292, 41.1%), females (117/179, 65.4%) had a significantly higher prevalence of anemia (P<0.001). The median (IQR) age of the patients with anemia was significantly higher than that of those without anemia (57.0 years vs. 51.5 years, respectively; P=0.003). Half the patients with malignant tumors had anemia. Anemia was more common among female patients and elderly patients.
癌症是一个全球性的健康问题,贫血是其表现之一。苏丹癌症患者贫血的数据尚未公布。目前的研究旨在调查苏丹中部恶性肿瘤患者贫血的患病率。回顾了2020年3月至12月苏丹格济拉大学癌症国家研究所收治的恶性肿瘤患者的医疗记录。在参与研究的471名患者中,292名(62.0%)为女性。中位(四分位间距,IQR)年龄为55岁(45-66岁)。癌症(109,23.1%)、结直肠/肛门直肠癌(88,18.7%)、头颈部癌(83,17.6%)、女性生殖道癌(70,14.9%)和前列腺癌(35,7.4%)是本研究中观察到的主要癌症。中位(IQR)血红蛋白为11.9(10.5-13.0)g/dl,237(50.3%)患者患有贫血。贫血的患病率从癌症患者的31.2%到癌症患者的82.9%不等。与男性(120/292,41.1%)相比,女性(117/179,65.4%)的贫血患病率显著较高(P<0.001)。贫血患者的中位年龄(IQR)显著高于无贫血患者(分别为57.0岁和51.5岁;P=0.003)。一半的恶性肿瘤患者患有贫血。贫血在女性患者和老年患者中更为常见。
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引用次数: 0
Antiaggreganti piastrinici e anticoagulanti: le competenze dell’internista 血小板抗凝血剂和抗凝血剂:内科医生的技能
IF 0.4 Q3 Medicine Pub Date : 2023-03-21 DOI: 10.4081/itjm.q.2023.1
Francesco Dentali, M. Silingardi
La terapia antiaggregante nelle sindromi coronariche acute. S. De Servi, A. Landi, C. Montalto, G. Crimi, S. Savonitto La terapia antiaggregante nella vasculopatia cerebrale acuta. M. Giorgi Pierfranceschi Impiego degli anticoagulanti nella fibrillazione atriale. B. Broccatelli, A. Patriarchi, M. Giustozzi, C. Becattini La terapia del tromboembolismo venoso. F. Dentali La terapia anticoagulante nel paziente oncologico. M. Ziliotti, L. Terroni, M.C. Ugolotti, C. Cademartiri La terapia anticoagulante orale nel paziente anziano, fragile o complesso. A. Dellasalda, A.Tedde, D. Arioli
急性冠状动脉综合征的抗聚集治疗。S.De Servi,A.Landi,C.Montalto,G.Crimi,S.Savonito抗聚集治疗急性脑血管病。M.Giorgi-Pierfranceschi抗凝药物在心房颤动中的应用。B.Broccatelli,A.Patriarchi,M.Giustozzi,C.Becattini静脉血栓栓塞症的治疗。F.牙科癌症患者的抗凝治疗。M.Ziliotti、L.Terroni、M.C.Ugolotti、C.Cademartri老年、脆弱或复杂患者的口服抗凝治疗。A.Dellasalda、A.Tedde、D.Arioli
{"title":"Antiaggreganti piastrinici e anticoagulanti: le competenze dell’internista","authors":"Francesco Dentali, M. Silingardi","doi":"10.4081/itjm.q.2023.1","DOIUrl":"https://doi.org/10.4081/itjm.q.2023.1","url":null,"abstract":"\u0000La terapia antiaggregante nelle sindromi coronariche acute. \u0000S. De Servi, A. Landi, C. Montalto, G. Crimi, S. Savonitto \u0000La terapia antiaggregante nella vasculopatia cerebrale acuta. \u0000M. Giorgi Pierfranceschi \u0000Impiego degli anticoagulanti nella fibrillazione atriale. \u0000B. Broccatelli, A. Patriarchi, M. Giustozzi, C. Becattini \u0000La terapia del tromboembolismo venoso. \u0000F. Dentali \u0000La terapia anticoagulante nel paziente oncologico. \u0000M. Ziliotti, L. Terroni, M.C. Ugolotti, C. Cademartiri \u0000La terapia anticoagulante orale nel paziente anziano, fragile o complesso. \u0000A. Dellasalda, A.Tedde, D. Arioli","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47682144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of β2 microglobulin level and glomerular filtration rate in patients with acute leukemia after hematopoietic stem cell transplantation 急性白血病造血干细胞移植后β2微球蛋白水平与肾小球滤过率的关系
IF 0.4 Q3 Medicine Pub Date : 2023-02-16 DOI: 10.4081/itjm.2023.1563
A. Murzakhmetova, V. Kamkhen, A. Ainabay, Assel M. Meiramova, V. Kemaykin, B. Ainabekova
Hematopoietic stem cell transplantation is a life-saving therapy in patients suffering from acute leukemia. However, kidney complications developed after performing hematopoietic stem cell transplantation can affect the course and prognosis of the disease in patients with acute leukemia. This study is aimed at assessing the functional status of the kidneys in patients with acute leukemia who have undergone hematopoietic stem cell transplantation. The study has observed a group of patients with acute lymphoblastic leukemia and acute myeloid leukemia who have undergone hematopoietic stem cell transplantation. It has been discovered that β2 microglobulin is a sensitive method of analyzing renal function, with the β2 microglobulin threshold urine level not exceeding 0.3 mg/L. The complex diagnostics of kidney function in hematopoietic stem cell transplantation recipients has given the opportunity to identify the relationship between increased β2 microglobulin levels and decreased glomerular filtration rate. It has been determined that β2 microglobulin is a biomarker of renal disorders. The obtained data have showed that β2 microglobulin can be used as a diagnostic marker of reduced kidney function.
造血干细胞移植是挽救急性白血病患者生命的一种疗法。然而,造血干细胞移植后出现的肾脏并发症会影响急性白血病患者的病程和预后。本研究旨在评估急性白血病患者接受造血干细胞移植后肾脏的功能状态。本研究观察了一组接受造血干细胞移植的急性淋巴细胞白血病和急性髓性白血病患者。研究发现β2微球蛋白是一种灵敏的肾功能分析方法,β2微球蛋白阈值尿液不超过0.3 mg/L。造血干细胞移植受者肾功能的复杂诊断为确定β2微球蛋白水平升高与肾小球滤过率降低之间的关系提供了机会。已确定β2微球蛋白是肾脏疾病的生物标志物。结果表明β2微球蛋白可作为肾功能减退的诊断指标。
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引用次数: 0
The management of heart failure: a FADOI survey in the setting of Internal Medicine Units 心衰的管理:一项FADOI调查在内科单位设置
IF 0.4 Q3 Medicine Pub Date : 2023-02-16 DOI: 10.4081/itjm.2023.1573
F. Gallucci
Heart failure (HF) is a chronic disease characterized by high morbidity and mortality. FADOI conducted a survey aimed at obtaining information on the management of HF in Italy, with particular reference to the Internal Medicine (IM) Units. The questionnaire, containing 32 questions, was sent to the Directors. Up to August 2022, it was possible to analyze data from140 centers. In 47.4±17.2% of cases with HF, the patients have preserved systolic function; 41% are in NYHA class III, 33% in class IV (33%), 21% and 5% in NYHA class II and I, respectively. The mean length of hospital stay is 9±2.5 days, with an inhospital mortality of 11.9%±9.5%. After discharge, the re-hospitalizations are 21.3±12.7%. In 44.4% of IM departments, there is a formal diagnostic-therapeutic care pathway. Also, through surveys, it is possible to help hospitals to and optimize assistance to patients affected by HF.
心力衰竭(HF)是一种以高发病率和死亡率为特征的慢性疾病。FADOI进行了一项调查,旨在获得意大利心衰管理的信息,特别是关于内科(IM)部门的信息。载有32个问题的调查表已送交各董事。截至2022年8月,可以分析来自140个中心的数据。在47.4±17.2%的HF病例中,患者的收缩功能保留;NYHA III类占41%,IV类占33% (33%),NYHA II类占21%,I类占5%。平均住院时间为9±2.5天,住院死亡率为11.9%±9.5%。出院后再住院率为21.3±12.7%。44.4%的内科有正式的诊断-治疗护理途径。此外,通过调查,可以帮助医院优化对心衰患者的援助。
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引用次数: 0
期刊
Italian Journal of Medicine
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