Fatima Shaukat, Muhammad Owais Aziz, S. Abrar, A. Abbasi, T. Shamsi
We wish to share with the readers of this scientific journal our experiences and observations regarding educational gains achieved by the consultant faculty and trainee postgraduate residents via active participation in multidisciplinary team (MDT) Tumor Boards. The rapid modernization of teaching methodologies is being observed in both postgraduate residents and faculty professional education learning processes. Contemporary literature is increasingly depicting academic work which is being directed towards the exploration of both educational and social determinants of health care [1]. Several socio-economic factors have been discussed across the globe which have an impact on the health care systems [2]. Researchers argued over the fact that the leading factor for a positive outcome is socioeconomic wellbeing especially for patients with diseases, like cancer, diabetes mellitus, etc. If we critically evaluate the curriculums designed on the principles of traditional problem-based learning and case-based learning, they are very well-established students centre approaches, but on their merit, they failed to provide a holistic picture of the patient care [3].
{"title":"Consultants & Trainees Active Participation in Multi-Disciplinary Team (MDT): Tumor Boards can Play a Major Role in the Achievement of their Academic Professional Development Goals","authors":"Fatima Shaukat, Muhammad Owais Aziz, S. Abrar, A. Abbasi, T. Shamsi","doi":"10.21089/njhs.63.0092","DOIUrl":"https://doi.org/10.21089/njhs.63.0092","url":null,"abstract":"We wish to share with the readers of this scientific journal our experiences and observations regarding educational gains achieved by the consultant faculty and trainee postgraduate residents via active participation in multidisciplinary team (MDT) Tumor Boards. The rapid modernization of teaching methodologies is being observed in both postgraduate residents and faculty professional education learning processes. Contemporary literature is increasingly depicting academic work which is being directed towards the exploration of both educational and social determinants of health care [1]. Several socio-economic factors have been discussed across the globe which have an impact on the health care systems [2]. Researchers argued over the fact that the leading factor for a positive outcome is socioeconomic wellbeing especially for patients with diseases, like cancer, diabetes mellitus, etc. If we critically evaluate the curriculums designed on the principles of traditional problem-based learning and case-based learning, they are very well-established students centre approaches, but on their merit, they failed to provide a holistic picture of the patient care [3].","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116343154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: COVID-19 is a public health international emergency. The objective is to gain the understanding on how this virus affects the human body and what were the risk factors affecting the morbidity and mortality. Materials and Methods: The data was collected from Chaudhry Muhammad Akram research and teaching hospital. The data was collected from the patient notes and the Performa’s were filled. The population for study were in the age range of 30 to 70 years and both males and females were included. The pregnant women were not included in this study. The notes of patients were taken from the year 2021. Results: This retrospective study included hospitalized patients. The total patients included in this study were fifty. The symptoms studied were fatigue, fever, cough and shortness of breath. All the patients admitted complained of fatigue (100%). 21(42%) patients had fever. 23 patient (46%) complained of cough and 21(42%) had shortness of breath. The male admitted were 31 (62%) and females were 19. (38%) There were 3 patients (6%) admitted in the age ranging from 30-40 years, ten (20%) were 41-50 years, sixteen(32%) were 51-60 years old and twenty one(42%) were 61-70 years old. 40 (80%) patients completely recovered, 2 (4%)patients were referred to other hospital because of lack of required facilities. Twenty patients (40%) admitted had existing medical problem. Eight patients (16%) who were on ventilators had co morbidities like hypertension, diabetes, and obesity died. There were two women and six men who died. Conclusion: Our study concluded having any comorbidity increased the risk of hospital fatality with COVID-19. The data suggested that more males were admitted as compared to females. The fatality was more in male compared to females. Male sex can be identified as a risk factor for death. Most of patients belonged to group 51-70 years age. The survival rate in our study was 80%.
{"title":"The Impact of COVID-19 Pandemic in Pakistan","authors":"S. Sibtain, Aaleen Azeez","doi":"10.21089/njhs.63.0117","DOIUrl":"https://doi.org/10.21089/njhs.63.0117","url":null,"abstract":"Objective: COVID-19 is a public health international emergency. The objective is to gain the understanding on how this virus affects the human body and what were the risk factors affecting the morbidity and mortality. Materials and Methods: The data was collected from Chaudhry Muhammad Akram research and teaching hospital. The data was collected from the patient notes and the Performa’s were filled. The population for study were in the age range of 30 to 70 years and both males and females were included. The pregnant women were not included in this study. The notes of patients were taken from the year 2021. Results: This retrospective study included hospitalized patients. The total patients included in this study were fifty. The symptoms studied were fatigue, fever, cough and shortness of breath. All the patients admitted complained of fatigue (100%). 21(42%) patients had fever. 23 patient (46%) complained of cough and 21(42%) had shortness of breath. The male admitted were 31 (62%) and females were 19. (38%) There were 3 patients (6%) admitted in the age ranging from 30-40 years, ten (20%) were 41-50 years, sixteen(32%) were 51-60 years old and twenty one(42%) were 61-70 years old. 40 (80%) patients completely recovered, 2 (4%)patients were referred to other hospital because of lack of required facilities. Twenty patients (40%) admitted had existing medical problem. Eight patients (16%) who were on ventilators had co morbidities like hypertension, diabetes, and obesity died. There were two women and six men who died. Conclusion: Our study concluded having any comorbidity increased the risk of hospital fatality with COVID-19. The data suggested that more males were admitted as compared to females. The fatality was more in male compared to females. Male sex can be identified as a risk factor for death. Most of patients belonged to group 51-70 years age. The survival rate in our study was 80%.","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126126430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Diabetes mellitus (DM) is a serious health burden and its frequency is increasing worldwide. Several complications are related with diabetes mellitus and now periodontal disease (PD) is also considered as DM-related problem. A 2-way association between DM and PDs has been reported. The purpose of this article is to deliver the knowledge relating to the association between DM and PDs. Several researches have been published over the past 50 years in this regard yet more research is obligatory so as to elucidate the two-way relationship trait between DM and PDs.
{"title":"Association between Diabetes Mellitus and Periodontal Diseases","authors":"Sahar Abdelkhalik Elsheikh, Khalid Mahmood Uddin, Shamail Zia, Syeda Alveera Batool, Fahmeeda Khatoon Junejo","doi":"10.21089/njhs.63.0121","DOIUrl":"https://doi.org/10.21089/njhs.63.0121","url":null,"abstract":"Objective: Diabetes mellitus (DM) is a serious health burden and its frequency is increasing worldwide. Several complications are related with diabetes mellitus and now periodontal disease (PD) is also considered as DM-related problem. A 2-way association between DM and PDs has been reported. The purpose of this article is to deliver the knowledge relating to the association between DM and PDs. Several researches have been published over the past 50 years in this regard yet more research is obligatory so as to elucidate the two-way relationship trait between DM and PDs.","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122714286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehmet Ali Kosekli, O. Ozmen, S. Sahinduran, M. Yılmaz
Introduction: Acute necrotizing pancreatitis with a high mortality rate and the search for treatment continues. We investigated the protective effect of Nigella Sativa (NS), with antioxidant and anti-inflammatory effects, in experimental acute necrotizing pancreatitis. Materials and Methods: Thirty six male Wistar albino rats (weights 180-220 g) were randomised into four groups. Group 1 (Control): Rats were given standard mouse chow. No pro-drug or pancreatic intervention was performed. Group 2 (NS): In addition to their standard diet, rats were given 0.1 ml/100gr of NS orally for 3 days prior to the experiment. Group 3: Necrotizing pancreatitis was induced by retrograde administration of 3% Na-Taurocholate through the distal common bile duct of the rats on on experiment day. Group 4 (NS+ANP): Necrotizing pancreatitis was also formed in rats receiving 0.1ml/100 mg of NS for 3 days. Rats were given high-dose anesthesia 8 hours after the onset of pancreatitis. Immunohistochemical (TNF-a, MDA, MPO, Caspase), histological pancreatitis scoring and biochemical (LDH, Lipase, amylase) analyzes were performed from the blood and pancreatic tissue samples obtained. Results: There was no difference in histopathological, immunohistochemical and biochemical values between Group 1 and Group 2 (p>0.05). There were significiant differences between Group 4 and Group 3 in terms of histopathological, immunohistochemical and biochemical parameters (p<0.001). The pancreatitis findings of the Group 4 were found to be significantly milder than Group 3, which did not receive NS. Conclusion: NS pretreatment alleviates NaTaurocholate-induced experimental pancreatitis. NS firstly studied in experimental models of pancreatitis.
{"title":"Protective Effect of Nigella Sativa on Taurocholate Induced Pancreatitis in Rats","authors":"Mehmet Ali Kosekli, O. Ozmen, S. Sahinduran, M. Yılmaz","doi":"10.21089/njhs.63.0105","DOIUrl":"https://doi.org/10.21089/njhs.63.0105","url":null,"abstract":"Introduction: Acute necrotizing pancreatitis with a high mortality rate and the search for treatment continues. We investigated the protective effect of Nigella Sativa (NS), with antioxidant and anti-inflammatory effects, in experimental acute necrotizing pancreatitis. Materials and Methods: Thirty six male Wistar albino rats (weights 180-220 g) were randomised into four groups. Group 1 (Control): Rats were given standard mouse chow. No pro-drug or pancreatic intervention was performed. Group 2 (NS): In addition to their standard diet, rats were given 0.1 ml/100gr of NS orally for 3 days prior to the experiment. Group 3: Necrotizing pancreatitis was induced by retrograde administration of 3% Na-Taurocholate through the distal common bile duct of the rats on on experiment day. Group 4 (NS+ANP): Necrotizing pancreatitis was also formed in rats receiving 0.1ml/100 mg of NS for 3 days. Rats were given high-dose anesthesia 8 hours after the onset of pancreatitis. Immunohistochemical (TNF-a, MDA, MPO, Caspase), histological pancreatitis scoring and biochemical (LDH, Lipase, amylase) analyzes were performed from the blood and pancreatic tissue samples obtained. Results: There was no difference in histopathological, immunohistochemical and biochemical values between Group 1 and Group 2 (p>0.05). There were significiant differences between Group 4 and Group 3 in terms of histopathological, immunohistochemical and biochemical parameters (p<0.001). The pancreatitis findings of the Group 4 were found to be significantly milder than Group 3, which did not receive NS. Conclusion: NS pretreatment alleviates NaTaurocholate-induced experimental pancreatitis. NS firstly studied in experimental models of pancreatitis.","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116703202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hamza Kaya, T. Duman, G. Kahveci, Elif Basaran, G. Aktas
Cobalamin deficiency anemia is a type of anemia that present with weakness, fatigue, icteric sclera and neuropathy. Main causes of cobalamin deficiency are low intake or decreased absorption (gastric and intestinal causes). In present case, we report a 65-year-old male who presented to the emergency department with signs and symptoms of cobalamin deficiency including bilateral peripheral neuropathy, icteric skin and sclera, and abdominal pain in right upper quadrant. He had low cobalamin and extremely high bilirubin levels (8mg/dL) in serum. After the diagnosis of cobalamin deficiency established, 1mg daily cobalamin treatment initiated for five days which would follow weekly and monthly intramuscular injections consequently. Hemolysis and other causes of elevated indirect bilirubin levels were excluded in differential diagnosis. Clinical and laboratory improvements were achieved after the treatment. In conclusion, physicians should kept in mind cobalamin deficiency even in subjects with unusual high levels of indirect bilirubin.
{"title":"An Exceptional Case of Cobalamin Deficiency that Presented with Extremely High Indirect Bilirubin Levels","authors":"Hamza Kaya, T. Duman, G. Kahveci, Elif Basaran, G. Aktas","doi":"10.21089/njhs.63.0140","DOIUrl":"https://doi.org/10.21089/njhs.63.0140","url":null,"abstract":"Cobalamin deficiency anemia is a type of anemia that present with weakness, fatigue, icteric sclera and neuropathy. Main causes of cobalamin deficiency are low intake or decreased absorption (gastric and intestinal causes). In present case, we report a 65-year-old male who presented to the emergency department with signs and symptoms of cobalamin deficiency including bilateral peripheral neuropathy, icteric skin and sclera, and abdominal pain in right upper quadrant. He had low cobalamin and extremely high bilirubin levels (8mg/dL) in serum. After the diagnosis of cobalamin deficiency established, 1mg daily cobalamin treatment initiated for five days which would follow weekly and monthly intramuscular injections consequently. Hemolysis and other causes of elevated indirect bilirubin levels were excluded in differential diagnosis. Clinical and laboratory improvements were achieved after the treatment. In conclusion, physicians should kept in mind cobalamin deficiency even in subjects with unusual high levels of indirect bilirubin.","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129584881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sana Khan, Khalid Mahmood Uddin, Shamail Zia, Cynthia Chizoba Esimoleze, Sarah Khalid, Farozaan Shamail, Fazail Zia, S. J. Ali, M. A. Khan
Objective: The categorization of sweat gland tumors has been inconsistent over time. These tumors, having varying potential for malignancy, may behave as indolent neoplasms while others can be highly metastatic. The characteristics of most of these tumors are overlapping and the information of distinctive findings about these neoplasms is imperative. Traditionally, sweat gland tumors were classified as eccrine and apocrine only but recently, this has been found that several sweat gland tumors may exhibit eccrine and apocrine types both. Some tumors exhibit further complex features due to the existence of other differential appearances. This can be in the instance of apocrine neoplasms because of the close embryological link between apocrine glands, hair follicles and sebaceous glands and they can be classified as follicular and/or sebaceous tumors. Cutaneous adnexal neoplasms are a diagnostic challenge, especially for tumors with sweat gland differentiation, due to a huge number of uncommon entities, designation of different terms to the identical tumor following to disagreement about the taxonomy and nomenclature of such tumors. This review article provides updated information about various cancerous sweat gland neoplasms with emphasis on recent conclusions for the diagnosis and generalized therapy of such neoplasms.
{"title":"Sweat Gland Tumors – A Systematic Review on the Histopathology and Immunohistochemistry","authors":"Sana Khan, Khalid Mahmood Uddin, Shamail Zia, Cynthia Chizoba Esimoleze, Sarah Khalid, Farozaan Shamail, Fazail Zia, S. J. Ali, M. A. Khan","doi":"10.21089/njhs.63.0129","DOIUrl":"https://doi.org/10.21089/njhs.63.0129","url":null,"abstract":"Objective: The categorization of sweat gland tumors has been inconsistent over time. These tumors, having varying potential for malignancy, may behave as indolent neoplasms while others can be highly metastatic. The characteristics of most of these tumors are overlapping and the information of distinctive findings about these neoplasms is imperative. Traditionally, sweat gland tumors were classified as eccrine and apocrine only but recently, this has been found that several sweat gland tumors may exhibit eccrine and apocrine types both. Some tumors exhibit further complex features due to the existence of other differential appearances. This can be in the instance of apocrine neoplasms because of the close embryological link between apocrine glands, hair follicles and sebaceous glands and they can be classified as follicular and/or sebaceous tumors. Cutaneous adnexal neoplasms are a diagnostic challenge, especially for tumors with sweat gland differentiation, due to a huge number of uncommon entities, designation of different terms to the identical tumor following to disagreement about the taxonomy and nomenclature of such tumors. This review article provides updated information about various cancerous sweat gland neoplasms with emphasis on recent conclusions for the diagnosis and generalized therapy of such neoplasms.","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115025942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Sohail Ajmal Ghoauri, N. I. Butt, Muhammad Umair Javed, Muhammad Bilal Rasheed, S. Luqman, Sabir Ali
Abstract: A previously healthy 30-year old lady presented with 1-day history of high grade fever and drowsiness. Five days prior to presentation, she developed insomnia and visual hallucinations of seeing unknown faces. Three days prior to presentation, she suffered from 5 episodes of generalized tonic colonic fits. On admission, she had a temperature of 102oF and GCS of 10/15 with no signs of meningeal irritation, no focal neurological deficit, normal deep tendon reflexes and down-going plantar reflex bilaterally. Her brain MRI scan showed mild hyper-intense signals in right cerebellum. Her CSF was tested for Anti-NMDA receptor antibodies which were positive. She was diagnosed as having Anti-NMDA Receptor Encephalitis and started on immediate Plasma Exchange with drastic improvement.
{"title":"Anti-NMDA Receptor Encephalitis: A Rare but Important Auto-Immune Cause of Encephalitis","authors":"Muhammad Sohail Ajmal Ghoauri, N. I. Butt, Muhammad Umair Javed, Muhammad Bilal Rasheed, S. Luqman, Sabir Ali","doi":"10.21089/njhs.73.0136","DOIUrl":"https://doi.org/10.21089/njhs.73.0136","url":null,"abstract":"Abstract: A previously healthy 30-year old lady presented with 1-day history of high grade fever and drowsiness. Five days prior to presentation, she developed insomnia and visual hallucinations of seeing unknown faces. Three days prior to presentation, she suffered from 5 episodes of generalized tonic colonic fits. On admission, she had a temperature of 102oF and GCS of 10/15 with no signs of meningeal irritation, no focal neurological deficit, normal deep tendon reflexes and down-going plantar reflex bilaterally. Her brain MRI scan showed mild hyper-intense signals in right cerebellum. Her CSF was tested for Anti-NMDA receptor antibodies which were positive. She was diagnosed as having Anti-NMDA Receptor Encephalitis and started on immediate Plasma Exchange with drastic improvement.","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124345734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is just over a year when the medical and scientist community lost a beloved and respected icon, my friend Prof. Dr. Tahir Sultan Shamsi (Late). Held in admiration and loved by all of us, this kind and humble doctor treated patients, colleagues, students with compassion and expertise. He was truly adored and trusted by all. He started his early carrier in Pakistan as Consultant Hematologist at SIUT and Ziauddin Hospital to eventually begin to lay the ground work for setting up NIBD from few rooms to the first class institute that it evolved into in his later years. He continued his services as Consultant Hematologist & Transplant Physician, Medical Director and Professor of Hematology, at the National Institute of Blood Disease & Bone Marrow Transplantation till the end. Under his dynamic leadership NIBD flourished and metamorphosed into a world class institute for blood diseases and BMT that served all regardless of their financial background, with Prof. Dr. Tahir Sultan Shamsi (Late) arranging funds from public and private sources to ensure that no one suffered. A supremely gifted researcher (229 publications, 133 abstracts, author and contributor of 29 books with an impressive impact factor of 473.345), he spearheaded a dynamic teaching and training program for Post Graduate doctors, nurses and technicians. He supervised 30 FCPS fellows, 15 BMT and 5 Pediatric Hematologist fellows apart from half a dozen PhD fellows. This skilled resource triggered a multiplier effect of setting up BMT in other institutes in Pakistan – a notable change indeed. Member of various scientific and social bodies and on editorial board of various journals, Prof. Dr. Tahir Sultan Shamsi (Late) launched the National Journal of Health Sciences (NJHS) and worked tirelessly to facilitate research and raise standards. It is only his legacy and vision that the Journal is not only recognized by different international indexing agencies and has now been accredited by the Higher Education Commission (HEC). The editorial board is indebted to our dear friend and colleague Prof. Dr. Tahir Sultan Shamsi (Late) and would Insha’Allah endeavor to continue in the guiding path set by him. May God bless Him.
就在一年多前，医学界和科学界失去了一位深受爱戴和尊敬的偶像，我的朋友Tahir Sultan Shamsi博士教授(已故)。这位善良而谦逊的医生以同情心和专业知识对待病人、同事和学生，受到我们所有人的钦佩和爱戴。他深受大家的爱戴和信任。他在巴基斯坦作为SIUT和Ziauddin医院的顾问血液学家开始了他的早期工作，最终开始为建立NIBD奠定基础，从几个房间发展成为一流的研究所，并在他晚年发展成为一流的研究所。他继续担任顾问血液学家和移植医师，医学主任和血液学教授，在国家血液疾病和骨髓移植研究所直到最后。在他充满活力的领导下，NIBD蓬勃发展，并发展成为世界一流的血液疾病和BMT研究所，为所有人提供服务，无论他们的经济背景如何，Tahir Sultan Shamsi博士(已故)教授安排了公共和私人来源的资金，以确保没有人遭受损失。他是一位极具天赋的研究人员(229篇出版物，133篇摘要，29本书的作者和贡献者，影响因子达到了令人印象深刻的473.345)，他为研究生医生，护士和技术人员提供了一个充满活力的教学和培训计划。他指导了30名FCPS研究员，15名BMT研究员和5名儿科血液学家研究员以及6名博士研究员。这一技术资源引发了在巴基斯坦其他研究所建立BMT的乘数效应——这确实是一个显著的变化。Tahir Sultan Shamsi博士教授(已故)是各种科学和社会机构的成员以及各种期刊的编辑委员会成员，他创办了《国家卫生科学杂志》(NJHS)，并为促进研究和提高标准而不懈努力。正是由于他的遗产和远见卓识，《华尔街日报》不仅得到了不同国际索引机构的认可，现在还获得了高等教育委员会(HEC)的认可。编辑委员会感谢我们亲爱的朋友和同事塔希尔·苏丹·沙姆西博士(已故)教授，并愿真主安拉努力继续走他所确定的道路。愿上帝保佑他。
{"title":"Man Sure Passes Away but Memories and Ideas Remain","authors":"Shahid Kamal","doi":"10.21089/njhs.73.0104","DOIUrl":"https://doi.org/10.21089/njhs.73.0104","url":null,"abstract":"It is just over a year when the medical and scientist community lost a beloved and respected icon, my friend Prof. Dr. Tahir Sultan Shamsi (Late). Held in admiration and loved by all of us, this kind and humble doctor treated patients, colleagues, students with compassion and expertise. He was truly adored and trusted by all. He started his early carrier in Pakistan as Consultant Hematologist at SIUT and Ziauddin Hospital to eventually begin to lay the ground work for setting up NIBD from few rooms to the first class institute that it evolved into in his later years. He continued his services as Consultant Hematologist & Transplant Physician, Medical Director and Professor of Hematology, at the National Institute of Blood Disease & Bone Marrow Transplantation till the end. Under his dynamic leadership NIBD flourished and metamorphosed into a world class institute for blood diseases and BMT that served all regardless of their financial background, with Prof. Dr. Tahir Sultan Shamsi (Late) arranging funds from public and private sources to ensure that no one suffered. A supremely gifted researcher (229 publications, 133 abstracts, author and contributor of 29 books with an impressive impact factor of 473.345), he spearheaded a dynamic teaching and training program for Post Graduate doctors, nurses and technicians. He supervised 30 FCPS fellows, 15 BMT and 5 Pediatric Hematologist fellows apart from half a dozen PhD fellows. This skilled resource triggered a multiplier effect of setting up BMT in other institutes in Pakistan – a notable change indeed. Member of various scientific and social bodies and on editorial board of various journals, Prof. Dr. Tahir Sultan Shamsi (Late) launched the National Journal of Health Sciences (NJHS) and worked tirelessly to facilitate research and raise standards. It is only his legacy and vision that the Journal is not only recognized by different international indexing agencies and has now been accredited by the Higher Education Commission (HEC). The editorial board is indebted to our dear friend and colleague Prof. Dr. Tahir Sultan Shamsi (Late) and would Insha’Allah endeavor to continue in the guiding path set by him. May God bless Him.","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128941417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Syed Rashid-ul- Amin, Abdul Hai, H. Ali, Najeeb Niamatullah, A. Hashmi
Abstract: Background: Biochemical recurrence is seen in 27–53% of carcinoma prostate patients after treatment. GS (Gleason score) and baseline PSA level are a predictor of recurrence. Post- treatment persistent rising PSA levels represent the recurrence and PSMA labelled PET-CT is an important part of imaging workup in these patients. Objective: To detect the relationship between PSA levels and Gleason score in patients investigated for Gallium-PSMA-11 fused molecular imaging in biochemical recurrent carcinoma prostate. Materials and Methods: This cross-sectional study was carried out at S.I.U.T Karachi. PSMA-PET/CT scans (September 2017-January 2022) of the patient who had a biochemical recurrence and not receiving any cancer-specific treatment at least 4 weeks prior scan were included. PSA level from lab reports and GS from the histopathological reports was recorded. Biochemical recurrence were defined as when PSA level > 0.4ng/ml (post-prostatectomy) or >2.0 ng/ml higher than the nadir value after radiotherapy. PET/CT scans of 106 included patients were interpreted by the nuclear physician and radiologist team. SUVmax ≥ 2.5 was considered positive for recurrence. Local recurrences, lymphnodal, osseous, and visceral metastasis were documented. Statistical analysis was done by utilizing IBM SPSS software (version 22.0). Results: In 88 of 106 patients (83%), Gallium-PSMA-11 PET/CT scan detected at least one lesion characteristic of recurrent PCa. The median PSA level was 12.1 (.01-892.0) ng/dl. In relating PSA value, it was noted that there was a significant difference between lesion positive and negative PSMA-11 labelled Ga-68 PET/CT scan but not statically significant for GS. Local recurrences were seen in 70 patients, whereas lymph node and osseous metastases were noted in 64 and 52 scans respectively. A PSA value of 0.68 ng/ml was determined by utilizing the ROC curve with an AUC of 0.924 (95% CI 0.86-0.98) and will likely predict the positive/negative PSMA-11 Gallium PET/CT scan. Conclusion: Raised PSA level may predict the possibility of a positive Ga-PSMA-11 PET/CT scan but there was no relationship noted between GS and Ga-PSMA-11 PET/CT findings.
{"title":"Role of 68Ga-PSMA PET/CT in Patients with Recurrent Prostate Cancer and its Comparison with Serum PSA Levels and Gleason Scores","authors":"Syed Rashid-ul- Amin, Abdul Hai, H. Ali, Najeeb Niamatullah, A. Hashmi","doi":"10.21089/njhs.73.0115","DOIUrl":"https://doi.org/10.21089/njhs.73.0115","url":null,"abstract":"Abstract: Background: Biochemical recurrence is seen in 27–53% of carcinoma prostate patients after treatment. GS (Gleason score) and baseline PSA level are a predictor of recurrence. Post- treatment persistent rising PSA levels represent the recurrence and PSMA labelled PET-CT is an important part of imaging workup in these patients. Objective: To detect the relationship between PSA levels and Gleason score in patients investigated for Gallium-PSMA-11 fused molecular imaging in biochemical recurrent carcinoma prostate. Materials and Methods: This cross-sectional study was carried out at S.I.U.T Karachi. PSMA-PET/CT scans (September 2017-January 2022) of the patient who had a biochemical recurrence and not receiving any cancer-specific treatment at least 4 weeks prior scan were included. PSA level from lab reports and GS from the histopathological reports was recorded. Biochemical recurrence were defined as when PSA level > 0.4ng/ml (post-prostatectomy) or >2.0 ng/ml higher than the nadir value after radiotherapy. PET/CT scans of 106 included patients were interpreted by the nuclear physician and radiologist team. SUVmax ≥ 2.5 was considered positive for recurrence. Local recurrences, lymphnodal, osseous, and visceral metastasis were documented. Statistical analysis was done by utilizing IBM SPSS software (version 22.0). Results: In 88 of 106 patients (83%), Gallium-PSMA-11 PET/CT scan detected at least one lesion characteristic of recurrent PCa. The median PSA level was 12.1 (.01-892.0) ng/dl. In relating PSA value, it was noted that there was a significant difference between lesion positive and negative PSMA-11 labelled Ga-68 PET/CT scan but not statically significant for GS. Local recurrences were seen in 70 patients, whereas lymph node and osseous metastases were noted in 64 and 52 scans respectively. A PSA value of 0.68 ng/ml was determined by utilizing the ROC curve with an AUC of 0.924 (95% CI 0.86-0.98) and will likely predict the positive/negative PSMA-11 Gallium PET/CT scan. Conclusion: Raised PSA level may predict the possibility of a positive Ga-PSMA-11 PET/CT scan but there was no relationship noted between GS and Ga-PSMA-11 PET/CT findings.","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123827634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract: Background: Increased hospitalization and death rates up to 2-3 times greater due to cardiovascular diseases have been reported in Chronic Obstructive Pulmonary Disease (COPD) cases. Inflammation, neurohumoral activation, and increased oxidative stress are involved in the etiopathogenesis of both disease groups. Objective: The study aimed to retrospectively evaluate the patients with COPD with perfusion defects (ischemia/infarct) in myocardial perfusion scintigraphy and investigate the clinical features of these patients. Materials and Methods: Patients with COPD were included in the study by examining the files of 196 patients who had perfusion defects by performing myocardial perfusion scintigraphy (MPS) in the Nuclear Medicine Clinic of our hospital between January 2019-2021. Demographic data, comorbidities, areas of involvement in myocardial perfusion scintigraphy, pulmonary function test (PFT), smoking history, modified Medical Research Council (mMRC) score, pulse oxygen saturation, and echocardiography (ECHO) data were recorded. Results: COPD was detected in 6 (3%) of 196 patients. All of these cases were male and the age range was 67.2 ± 7.4 years. All 6 cases were male, and the mean age was 67.2 ± 7.4 years. They all had a history of heavy smoking (52.5 ± 30.9 packs/year). The mean forced expiratory volume in 1 second (FEV1) was 49.6 ± 8.9%, and pulse oxygen saturation was 93.2 ± 3.3%. In ECHO, systolic pulmonary artery pressure (PAPs) was higher than normal in 2 patients; one had advanced mitral insufficiency and heart failure. In the MPS of 4 patients, an infarct was observed in the area supplied by the right coronary artery (RCA). While there was no comorbid disease in 2 patients, comorbid diseases were present in 4. There was no significant difference between the non-COPD group and the COPD group in terms of age and gender. In the non-COPD group, the most common LAD localized defect (35.3%) and RCA localized defect (23.2%) were detected, while the most common RCA defect (50%) was found in the COPD group. However, it was not statistically significant due to the small sample size. Conclusion: In COPD cases, it was determined that infarct developed in the male gender, advanced age and advanced stage, and especially in the area fed with RCA if exposed to heavy smoking. It is considered that the ischemic changes observed in RCA in COPD may have a role in the development of right heart failure.
{"title":"Clinical Overview of Chronic Obstructive Pulmonary Disease Patients with Myocardial Perfusion Defect","authors":"Emine Afşin, Hamdi Afsin","doi":"10.21089/njhs.73.0105","DOIUrl":"https://doi.org/10.21089/njhs.73.0105","url":null,"abstract":"Abstract: Background: Increased hospitalization and death rates up to 2-3 times greater due to cardiovascular diseases have been reported in Chronic Obstructive Pulmonary Disease (COPD) cases. Inflammation, neurohumoral activation, and increased oxidative stress are involved in the etiopathogenesis of both disease groups. Objective: The study aimed to retrospectively evaluate the patients with COPD with perfusion defects (ischemia/infarct) in myocardial perfusion scintigraphy and investigate the clinical features of these patients. Materials and Methods: Patients with COPD were included in the study by examining the files of 196 patients who had perfusion defects by performing myocardial perfusion scintigraphy (MPS) in the Nuclear Medicine Clinic of our hospital between January 2019-2021. Demographic data, comorbidities, areas of involvement in myocardial perfusion scintigraphy, pulmonary function test (PFT), smoking history, modified Medical Research Council (mMRC) score, pulse oxygen saturation, and echocardiography (ECHO) data were recorded. Results: COPD was detected in 6 (3%) of 196 patients. All of these cases were male and the age range was 67.2 ± 7.4 years. All 6 cases were male, and the mean age was 67.2 ± 7.4 years. They all had a history of heavy smoking (52.5 ± 30.9 packs/year). The mean forced expiratory volume in 1 second (FEV1) was 49.6 ± 8.9%, and pulse oxygen saturation was 93.2 ± 3.3%. In ECHO, systolic pulmonary artery pressure (PAPs) was higher than normal in 2 patients; one had advanced mitral insufficiency and heart failure. In the MPS of 4 patients, an infarct was observed in the area supplied by the right coronary artery (RCA). While there was no comorbid disease in 2 patients, comorbid diseases were present in 4. There was no significant difference between the non-COPD group and the COPD group in terms of age and gender. In the non-COPD group, the most common LAD localized defect (35.3%) and RCA localized defect (23.2%) were detected, while the most common RCA defect (50%) was found in the COPD group. However, it was not statistically significant due to the small sample size. Conclusion: In COPD cases, it was determined that infarct developed in the male gender, advanced age and advanced stage, and especially in the area fed with RCA if exposed to heavy smoking. It is considered that the ischemic changes observed in RCA in COPD may have a role in the development of right heart failure.","PeriodicalId":441304,"journal":{"name":"National Journal of Health Sciences","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116443239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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