Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.248
Nadia Di Franco, A. Bortolozzi, L. Campo, Marc Espina Cortes, Laura Lopez, Silvia Ginés Padrós
{"title":"I22 Cannabinoid receptor in hippocampal hippocampus as a potential therapeutic treatment for the cognitive deficits in Huntington dieases","authors":"Nadia Di Franco, A. Bortolozzi, L. Campo, Marc Espina Cortes, Laura Lopez, Silvia Ginés Padrós","doi":"10.1136/jnnp-2022-ehdn.248","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.248","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122036806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.242
C. Mounier, Maxime Brilland, M. Marinozzi, P. Vanhoutte, J. Caboche, S. Betuing
{"title":"I16 LXR signaling in the striatum and neuroprotection in Huntington’s disease","authors":"C. Mounier, Maxime Brilland, M. Marinozzi, P. Vanhoutte, J. Caboche, S. Betuing","doi":"10.1136/jnnp-2022-ehdn.242","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.242","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130914313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.230
L. V. D. Bent, C. Brouwers, Robin Pocornie, A. Stam, Steffi Jonk, J. Klíma, Š. Juhás, J. Motlík, M. Evers, Zdenka Ellederovaé, A. Vallès
{"title":"I04 Aav5-mihtt gene therapy mediates sustained mutant huntingtin lowering in brain and cerebrospinal fluid of Huntington disease minipigs up to 4 years","authors":"L. V. D. Bent, C. Brouwers, Robin Pocornie, A. Stam, Steffi Jonk, J. Klíma, Š. Juhás, J. Motlík, M. Evers, Zdenka Ellederovaé, A. Vallès","doi":"10.1136/jnnp-2022-ehdn.230","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.230","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133067114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.229
M. Surdyka, A. Niewiadomska-Cimicka, Żaneta Kalinowska-Pośka, Ewelina Jesion, Elisabeth Singer-Mikosch, Lorraine Fievet, Agnieszka Fiszer, N. Caron, Michael R. Hayden, H. Nguyen, Y. Trottier, M. Figiel
{"title":"I03 CAG-targeted brain-permeable protein lowering strategy tested in polyQ mouse models","authors":"M. Surdyka, A. Niewiadomska-Cimicka, Żaneta Kalinowska-Pośka, Ewelina Jesion, Elisabeth Singer-Mikosch, Lorraine Fievet, Agnieszka Fiszer, N. Caron, Michael R. Hayden, H. Nguyen, Y. Trottier, M. Figiel","doi":"10.1136/jnnp-2022-ehdn.229","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.229","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124730345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.243
M. Valenza, Giulia Birolini, I. Ottonelli, F. Talpo, A. Passoni, Monica Favagrossa, L. Colombo, Riccardo Caraffi, C. Caccia, Valerio Leoni, F. Taroni, A. Cappelleri, L. Minoli, S. Paltrinieri, E. Scanziani, B. Ruozi, M. Salmona, G. Biella, G. Tosi, E. Cattaneo
{"title":"I17 Sustained benefits of brain-permeable cholesterol-loaded nanoparticles in zQ175DN mouse model","authors":"M. Valenza, Giulia Birolini, I. Ottonelli, F. Talpo, A. Passoni, Monica Favagrossa, L. Colombo, Riccardo Caraffi, C. Caccia, Valerio Leoni, F. Taroni, A. Cappelleri, L. Minoli, S. Paltrinieri, E. Scanziani, B. Ruozi, M. Salmona, G. Biella, G. Tosi, E. Cattaneo","doi":"10.1136/jnnp-2022-ehdn.243","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.243","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117300519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.244
G. Pepe, L. Capocci, F. Marracino, N. Realini, P. Scarselli, Clotilde Di Cicco, A. Armirotti, R. Parlato, A. D. Pardo, V. Maglione
{"title":"I18 Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase (SGPL1), modulates glycosphingolipid metabolism and results therapeutically effective in a mouse model of Huntington’s disease","authors":"G. Pepe, L. Capocci, F. Marracino, N. Realini, P. Scarselli, Clotilde Di Cicco, A. Armirotti, R. Parlato, A. D. Pardo, V. Maglione","doi":"10.1136/jnnp-2022-ehdn.244","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.244","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128750503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.237
Xuexin Li, Maria Häggblad, Lars Bräutigam, Jordi Carreras-Puigvert, D. Hühn, O. Fernandez-Capetillo
{"title":"I11 High throughput screening reveal drugs to rescue polyQ induced toxicity in Huntington’s disease cell and animal models","authors":"Xuexin Li, Maria Häggblad, Lars Bräutigam, Jordi Carreras-Puigvert, D. Hühn, O. Fernandez-Capetillo","doi":"10.1136/jnnp-2022-ehdn.237","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.237","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126873383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.235
D. Todd, Marta Stebbeds, Emma Thatcher, A. Barnard, Jeremy Anton, Arnold R. Sienerth, M. Visser, Philip Mitchell, P. Breccia, David Smith, G. Mcallister, T. Haque, Longbin Liu, C. Dominguez, I. Muñoz-Sanjuán
{"title":"I09 A Huntington’s disease embryonic stem cell phenotypic hts to identify small molecule modulators of mutant huntingtin","authors":"D. Todd, Marta Stebbeds, Emma Thatcher, A. Barnard, Jeremy Anton, Arnold R. Sienerth, M. Visser, Philip Mitchell, P. Breccia, David Smith, G. Mcallister, T. Haque, Longbin Liu, C. Dominguez, I. Muñoz-Sanjuán","doi":"10.1136/jnnp-2022-ehdn.235","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.235","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128137654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.234
G. Pepe, L. Capocci, F. Marracino, Clotilde Di Cicco, P. Scarselli, R. Parlato, A. D. Pardo, V. Maglione
{"title":"I08 Passive immunization, with the anti-huntingtin aggregate antibody EM48, is beneficial in R6/2 mouse model","authors":"G. Pepe, L. Capocci, F. Marracino, Clotilde Di Cicco, P. Scarselli, R. Parlato, A. D. Pardo, V. Maglione","doi":"10.1136/jnnp-2022-ehdn.234","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.234","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117162694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1136/jnnp-2022-ehdn.228
E. Kuijper, M. Overzier, E. Suidgeest, L. Weerd, L. Toonen, W. V. Roon-Mom
{"title":"I02 Therapeutic effect of antisense oligonucleotide treatment in YAC128 Huntington mice","authors":"E. Kuijper, M. Overzier, E. Suidgeest, L. Weerd, L. Toonen, W. V. Roon-Mom","doi":"10.1136/jnnp-2022-ehdn.228","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.228","url":null,"abstract":"","PeriodicalId":444837,"journal":{"name":"I: Experimental therapeutics – preclinical","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129826765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：