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A Different Scintigraphic Perspective on the Systolic Function of the Left Ventricle-1.
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-07 DOI: 10.4274/mirt.galenos.2024.60566
Alper Özgür Karaçalıoğlu
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引用次数: 0
Improved Accuracy and Reliability of PRIMARY Scoring Using Delayed [68Ga] Ga-PSMA PET/CT Imaging.
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-07 DOI: 10.4274/mirt.galenos.2025.16023
Kaan Akçay, Gamze Beydağı, Onur Erdem Şahin, Reşit Akyel, Elife Akgün, Özgül Ekmekçioğlu, Nalan Alan Selçuk, Türkay Toklu, Asiye Işın Doğan Ekici, Kayra Kapran, Levent Kabasakal

Objectives: Delayed [68Ga]Ga-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) images show reduced PSMA uptake in benign lesions and increased PSMA uptake in malignant lesions. This study investigated the efficacy of PRIMARY scoring on [68Ga]Ga-PSMA PET/CT images at standard versus delayed time points and assessed the potential added value of delayed imaging in PRIMARY scoring.

Methods: A total of 140 patients with biopsy results of International Society of Urological Pathology grade groups (ISUP) 1-2 who had standard (median 60 min) and delayed images (median 138 min) with [68Ga]Ga-PSMA PET/CT before radical prostatectomy were included. Results were confirmed in pathological reports. For diagnostic parameters, two experienced nuclear medicine physicians, who were blinded to clinical data, independently reviewed the images, and a third physician provided consensus in cases of disagreement. PRIMARY scoring was also conducted by four nuclear medicine physicians on both images, with a 1-month interval between assessments for intraobserver agreement analyses.

Results: The percentage of lesions scored as 1-2 in PRIMARY scoring decreased from 29% to 10% in delayed images compared with standard images, whereas lesions scored as 3-5 increased from 71% to 90%. Additionally, agreement between two experienced nuclear medicine physicians regarding scoring was 66% for standard imaging and 77% for delayed imaging. The number of patients with PRIMARY score 5 increased from 31 to 46 in delayed imaging. All patients were confirmed to have clinically significant prostate cancer (csPCa). Furthermore, no csPCa of ISUP grade 3 or higher was detected in patients with a delayed PRIMARY score (dPRIMARY). The sensitivity of standard PRIMARY scoring was 71%, which increased to 92% with dPRIMARY scoring, with a consistent positive predictive value of 87% for both. Intraobserver agreement Cohen's kappa values for all observers were higher for delayed images than for standard images. Inter-observer agreement, assessed by Fleiss kappa, was 0.47 and 0.52 for standard images in rounds 1 and 2, respectively, and 0.61 and 0.72 for delayed images, respectively.

Conclusion: Decreased background activity and increased primary tumor uptake in delayed images improved differentiation between primary tumors and benign lesions, leading to better primary tumor identification. Enhanced reliability was also observed in both intraobserver and interobserver assessments of delayed images.

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引用次数: 0
Image Analysis as tool for Predicting Colorectal Cancer Molecular Alterations: A Scoping Review.
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-07 DOI: 10.4274/mirt.galenos.2024.86402
Saman Mohammadpour, Hassan Emami, Reza Rabiei, Azamossadat Hosseini, Hamid Moghaddasi, Fariborz Faeghi, Rafat Bagherzadeh

Objectives: Among the most important diagnostic indicators of colorectal cancer; however, measuring molecular alterations are invasive and expensive. This study aimed to investigate the application of image processing to predict molecular alterations in colorectal cancer.

Methods: In this scoping review, we searched for relevant literature by searching the Web of Science, Scopus, and PubMed databases. The method of selecting the articles and reporting the findings was according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses; moreover, the Strengthening the Reporting of Observational Studies in Epidemiology checklist was used to assess the quality of the studies.

Results: Sixty seven out of 2,223 articles, 67 were relevant to the aim of the study, and finally 41 studies with sufficient quality were reviewed. The prediction of Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), Neuroblastoma RAS Viral (NRAS), B-Raf proto-oncogene, serine/threonine kinase (BRAF), Tumor Protein 53 (TP53), Adenomatous Polyposis Coli, and microsatellite instability (MSI) with the help of image analysis has received more attention than other molecular characteristics. The studies used computed tomography (CT), magnetic resonance imaging (MRI), and 18F-FDG positron emission tomography (PET)/CT with radionics and quantitative analysis to predict molecular alterations in colorectal cancer, analyzing features like texture, maximum standard uptake value, and MTV using various statistical methods. In 39 studies, there was a significant relationship between the features extracted from these images and molecular alterations. Different modalities were used to measure the area under the receiver operating characteristic curve for predicting the alterations in KRAS, MSI, BRAF, and TP53, with an average of 78, 81, 80 and 71%, respectively.

Conclusion: This scoping review underscores the potential of radiogenomics in predicting molecular alterations in colorectal cancer through non-invasive imaging modalities, like CT, MRI, and 18F-FDG PET/CT. The analysis of 41 studies showed the appropriate prediction of key alterations, such as KRAS, NRAS, BRAF, TP53, and MSI, highlighting the promise of radionics and texture features in enhancing predictive accuracy.

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引用次数: 0
Unexpected Detection of Cephalad Renal Ectopia Due to Large Omphalocele Containing the Liver on Tc-99m DMSA Scintigraphy.
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-07 DOI: 10.4274/mirt.galenos.2024.68095
Zeynep Işık, Cansu Küçüker, Murat Fani Bozkurt

Omphalocele is a congenital abdominal wall defect with herniation of abdominal viscera into a sac. Tc-99m DMSA renal cortical scan is a functional imaging technique used for detecting parenchymal defects, mostly in patients with recurrent urinary tract infection as well as congenital renal abnormalities. Renal anomalies are known to accompany omphalocele. In this retrospective study, we present a case of cephalad renal ectopia as observed on Tc-99m DMSA scintigraphy in a patient with omphalocele due to a large hernia sac containing most of the liver; and we review the renal abnormalities associated with omphalocele in the literature.

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引用次数: 0
Assessment of Y-90 Radioembolization Treatment Response for Hepatocellular Carcinoma Cases Using MRI Radiomics. 利用磁共振成像放射组学评估肝细胞癌病例的 Y-90 放射栓塞治疗反应
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-07 DOI: 10.4274/mirt.galenos.2024.59365
Mennaallah Mahmoud, Ko-Han Lin, Rheun-Chuan Lee, Chien-An Liu

Objectives: This study aimed to investigate the ability of radiomics features extracted from magnetic resonance imaging (MRI) images to differentiate between responders and non-responders for hepatocellular carcinoma (HCC) cases who received Y-90 transarterial radioembolization treatment.

Methods: Thirty-six cases of HCC who underwent MRI scans after Y-90 radioembolization were included in this study. Tumors were segmented from MRI T2 images, and then 87 radiomic features were extracted through the LIFEx package software. Treatment response was determined 9 months after treatment through the modified response evaluation criteria in solid tumours (mRECIST).

Results: According to mRECIST, 28 cases were responders and 8 cases were non-responders. Two radiomics features, "Grey Level Size Zone Matrix (GLSZM)-Small Zone Emphasis" and "GLSZM-Normalized Zone Size Non-Uniformity", were the radiomics features that could predict treatment response with the area under curve (AUC)= 0.71, sensitivity= 0.93, and specificity= 0.62 for both features. Whereas the other 4 features (kurtosis, intensity histogram root mean square, neighbourhood gray-tone difference matrix strength, and GLSZM normalized grey level non-uniformity) have a relatively lower but acceptable discrimination ability range from AUC= 0.6 to 0.66.

Conclusion: MRI radiomics analysis could be used to assess the treatment response for HCC cases treated with Y-90 radioembolization.

研究目的本研究旨在探讨从磁共振成像(MRI)图像中提取的放射组学特征区分接受 Y-90 经动脉放射栓塞治疗的肝细胞癌(HCC)病例中应答者和非应答者的能力:本研究纳入了 36 例接受 Y-90 经动脉放射栓塞治疗后接受磁共振成像扫描的 HCC 患者。从 MRI T2 图像中分割肿瘤,然后通过 LIFEx 软件包提取 87 个放射学特征。治疗9个月后,通过实体瘤改良反应评估标准(mRECIST)确定治疗反应:结果:根据 mRECIST,28 例有反应,8 例无反应。灰度大小区矩阵(GLSZM)-小区强调 "和 "GLSZM-归一化区大小不均匀 "这两个放射组学特征可以预测治疗反应,其曲线下面积(AUC)= 0.71,灵敏度= 0.93,特异度= 0.62。而其他 4 个特征(峰度、强度直方图均方根、邻近灰阶差矩阵强度和 GLSZM 归一化灰阶不均匀度)的辨别能力相对较低,但在 AUC= 0.6 至 0.66 之间,是可以接受的:磁共振成像放射组学分析可用于评估接受Y-90放射性栓塞治疗的HCC病例的治疗反应。
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引用次数: 0
Cooccurrence of Capsular Liver Lesions Along with Peritoneal Carcinomatosis and Hematogenous Metastases in Ovarian Cancer Patients on Consecutive 18F-FDG PET/CT Studies. 在连续的 18F-FDG PET/CT 研究中发现卵巢癌患者的囊性肝炎病变与腹膜癌肿和血行转移瘤同时存在。
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-07 DOI: 10.4274/mirt.galenos.2024.39269
Kemal Ünal, Levent Güner, Erkan Vardareli

Objectives: The aim of our study was to evaluate the cooccurrence of capsular liver lesions along with peritoneal carcinomatosis and hematogenous metastases in other regions of the body in ovarian cancer patients on follow-up F-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) studies.

Methods: Consecutive 18F-FDG PET/CT studies of 54 women with ovarian cancer between August 2012 and January 2020 and a total of 192 scans were analysed retrospectively. All patients had at least one hepatic and/or capsular lesion with high 18F-FDG uptake and at least two PET/CT examinations.

Results: According to interpretation, of 54 patients with hepatic or capsular lesions, 44 (81.4%), 5 (9.3%) and 5 (9.3%) of them were concluded as perihepatic implants, hematogenous liver metastases and both, respectively. Accompanying peritoneal carcinomatosis on follow-up PET/CT images was found in 42 (95.4%) and 3 (60%) patients with solely capsular lesions and solely hematogenous liver metastases, respectively. Extrahepatic hematogenous organ metastases on follow-up PET/CT images were seen in 4 (9.0%) and 3 (60%) patients with solely capsular lesions and solely hematogenous liver metastases, respectively. Lungs, bones, spleen and brain were detected metastases sites.

Conclusion: Cooccurrence of peritoneal carcinomatosis in other regions of abdomen was found to be higher in comparison to hematogenous organ metastases on consecutive PET/CT studies of ovarian cancer patients with capsular liver lesions. The primary opinion of the nuclear medicine physician is essential along with the other patient data for differential diagnosis and treatment approach in this particular patient group.

研究目的我们的研究旨在评估随访 F-18 氟脱氧葡萄糖(18F-FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)研究中卵巢癌患者肝囊病变与腹膜癌肿和身体其他区域血行转移的共存情况:回顾性分析了 2012 年 8 月至 2020 年 1 月期间对 54 名卵巢癌女性患者进行的连续 18F-FDG PET/CT 研究,共计 192 次扫描。所有患者都至少有一个肝脏和/或囊肿病灶具有高18F-FDG摄取,且至少接受过两次PET/CT检查:根据判读结果,在54例有肝脏或囊性病变的患者中,分别有44例(81.4%)、5例(9.3%)和5例(9.3%)被认定为肝周种植、血源性肝转移或两者兼而有之。42例(95.4%)和3例(60%)单纯囊性病变和单纯血源性肝转移的患者在随访PET/CT图像中发现伴有腹膜癌肿。在 PET/CT 随访图像上发现肝外血源性器官转移的患者分别有 4 例(9.0%)和 3 例(60%),分别为单纯囊性病变和单纯血源性肝转移。肺部、骨骼、脾脏和脑部也是检测到的转移部位:结论:在对有肝囊性病变的卵巢癌患者进行的连续 PET/CT 研究中发现,腹腔其他区域腹膜癌转移的并发率高于血源性器官转移。对于这一特殊患者群体,核医学医生的主要意见以及其他患者数据对于鉴别诊断和治疗方法至关重要。
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引用次数: 0
Impacts of 18F-FDG PET/CT Parameters on Differential Diagnosis and Outcome of Patients with Primary Invasive Mucinous and Lepidic Predominant Adenocarcinoma of the Lung. 18F-FDG PET/CT 参数对原发性侵袭性黏液腺癌和以表皮为主的肺腺癌患者的鉴别诊断和预后的影响
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-07 DOI: 10.4274/mirt.galenos.2024.24571
Ebru Tatcı, Özlem Özmen, Derya Kızılgöz, Funda Demirağ, Seçkin Bilgiç

Objectives: The purpose of this study was to investigate whether 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) parameters have a role in differentiating invasive mucinous lung adenocarcinoma (IMA) from lepidic predominant lung adenocarcinoma (LPA). Additionally, we compared the 18F-FDG-PET/CT features between survivors and non-survivors.

Methods: Tumors were divided into 2 groups according to CT appearance: Group 1: nodular-type tumor; group 2: mass- or pneumonic-type tumor. Unilateral and bilateral multifocal diseases were detected. Clinicopathological characteristics and PET/CT findings were compared between IMAs and LPAs, as well as between survivors and non-survivors.

Results: We included 43 patients with IMA and 14 with LPA. Tumor size (p=0.003), incidence of mass/pneumonic type (p=0.011), and bilateral lung involvement (p=0.049) were higher in IMAs than in LPAs. IMAs had more advanced T, M, and Tumor, Node, and Metastasis stages than in LPAs (p=0.048, p=0.049, and p=0.022, respectively). There was no statistically significant difference in maximum standardized uptake value (SUVmax) between the IMA and LPA (p=0.078). The SUV was significantly lower in the nodular group than in the mass/pneumonic-type group (p=0.0001). A total of 11 patients died, of whom SUVmax values were significantly higher in these patients (p=0.031). Male gender (p=0.0001), rate of stage III-IV (p=0.0001), T3-T4 (p=0.021), M1 stages (p=0.0001), multifocality (p=0.0001), and bilateral lung involvement (p=0.0001) were higher in non-survivor.

Conclusions: Although CT images were useful for the differential diagnosis of LPAs and IMAs, SUVmax was not helpful for differentiation of these 2 groups. However, both 18F-FDG uptake and CT findings may play an important role in predicting prognosis in these patients.

研究目的本研究旨在探讨18F-氟脱氧葡萄糖(18F-FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)参数是否有助于区分浸润性粘液性肺腺癌(IMA)和鳞状上皮型肺腺癌(LPA)。此外,我们还比较了存活者和非存活者的 18F-FDG-PET/CT 特征:方法:根据CT表现将肿瘤分为两组:第一组:结节型肿瘤;第二组:肿块型或气肿型肿瘤。检测单侧和双侧多灶性疾病。比较了 IMA 和 LPA 以及存活者和非存活者的临床病理特征和 PET/CT 结果:结果:我们纳入了 43 名 IMA 患者和 14 名 LPA 患者。IMA患者的肿瘤大小(p=0.003)、肿块/肺型的发生率(p=0.011)和双肺受累(p=0.049)均高于LPA患者。与LPA相比,IMA的T期、M期、肿瘤期、结节期和转移期更为晚期(分别为p=0.048、p=0.049和p=0.022)。IMA和LPA的最大标准化摄取值(SUVmax)差异无统计学意义(P=0.078)。结节组的 SUV 值明显低于肿块/气肿型组(P=0.0001)。共有 11 名患者死亡,其中这些患者的 SUVmax 值明显更高(P=0.031)。男性(p=0.0001)、III-IV期(p=0.0001)、T3-T4期(p=0.021)、M1期(p=0.0001)、多发(p=0.0001)和双肺受累(p=0.0001)在非存活患者中的比例较高:结论:虽然CT图像有助于鉴别诊断LPA和IMA,但SUVmax并不能帮助区分这两类患者。然而,18F-FDG 摄取和CT结果可能在预测这些患者的预后方面发挥重要作用。
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引用次数: 0
Prognostic Importance of 18F-FDG Positron Emission Tomography in Uterine Cervical Cancer 18F-FDG 正电子发射断层扫描在子宫颈癌中的预后意义
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-17 DOI: 10.4274/mirt.galenos.2024.57984
Ç. Soydal, M. H. Baltacıoğlu, M. Araz, Burak Demir, E. Dursun, S. Taşkın, N. O. Küçük, F. Ortaç
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引用次数: 0
Deep-learning-based Attenuation Correction for 68Ga-DOTATATE Whole-body PET Imaging: A Dual-center Clinical Study 基于深度学习的 68Ga-DOTATATE 全身 PET 成像衰减校正:双中心临床研究
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-17 DOI: 10.4274/mirt.galenos.2024.86422
Mahsa Sobhi Lord, J. Islamian, Negisa Seyyedi, Rezvan Samimi, Saeed Farzanehfar, Mahsa Shahrbabki, P. Sheikhzadeh
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引用次数: 0
The Utility of 18F-FDG PET/CT in Detecting Multiple Metastases in Papillary Renal Cell Carcinoma 18F-FDG PET/CT 在检测乳头状肾细胞癌多处转移中的实用性
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-17 DOI: 10.4274/mirt.galenos.2024.02259
Melis Oflas, Duygu Has Şimşek, S. Kuyumcu, Murat Yılmaz Kıran, Y. Şanlı
The diagnostic performance of 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) for primary kidney tumors is limited. Nevertheless, 18 F-FDG PET/CT is valuable for staging renal cell carcinoma (RCC) when suspected metastases coexist, as one-third of patients with RCC have distant metastases upon diagnosis. Herein, we present a 53-year-old male patient with extensive 18 F-FDG-avid metastatic lesions and an 18 F-FDG-avid renal mass, which later revealed RCC
18 F-氟脱氧葡萄糖(18 F-FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)对原发性肾肿瘤的诊断效果有限。尽管如此,18 F-FDG 正电子发射断层扫描/计算机断层扫描(PET/CT)在肾细胞癌(RCC)疑似转移灶并存时仍有分期价值,因为三分之一的 RCC 患者在确诊时已有远处转移。在此,我们介绍了一位 53 岁的男性患者,他患有广泛的 18 F-FDG 亲和转移灶和 18 F-FDG 亲和肾肿块,后来发现了 RCC
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引用次数: 0
期刊
Molecular Imaging and Radionuclide Therapy
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