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Prevalence of coeliac disease in children and adolescents with type 1 diabetes mellitus in a tertiary hospital in South Africa 南非一家三级医院1型糖尿病儿童和青少年腹腔疾病的患病率
IF 0.4 Q4 PEDIATRICS Pub Date : 2021-12-31 DOI: 10.7196/sajch.2021.v15i4.1841
M. Karsas, A. Terblanche, T. Kemp, J. van Dyk
Background. International literature has shown the prevalence of coeliac disease (CD) in children and adolescents with diabetes to range from 1 - 10%. Prevalence rates in African countries are limited or unknown. Objective. The objective was to describe the prevalence of CD in all children and adolescents with type 1 diabetes mellitus presenting to the paediatric and adult diabetic clinic at Steve Biko Academic Hospital, Pretoria, South Africa. Method. A retrospective review of the files of all children and adolescents in the paediatric and adult diabetic clinic with type 1 diabetes mellitus between August 2016 and June 2019 was conducted. Children requiring screening and/or intestinal biopsies were also prospectively included during this period. The setting of this study was Steve Biko Academic Hospital, a tertiary referral centre, in Pretoria, South Africa. Coeliac screening included anti-deaminated gliadin antibodies and anti-tissue transglutaminase antibodies (both IgA and IgG). All biopsies were obtained by a paediatric gastroenterologist or an experienced paediatric surgeon. Results. A total of 184 files were screened; 132 met inclusion criteria but only 108 patients in total had coeliac screening. Positive antibody screening for CD was found in 11 out of 108 patients (10.2%). Nine of the 11 serology-positive patients had biopsies performed. Out of the nine biopsies, two (22.2%) were positive for CD based on the Marsh-Oberhuber classification. Conclusion. This study found a prevalence of serology-positive CD in our local population of South African children with type 1 diabetes mellitus of 10.2%, while the prevalence of biopsy-confirmed CD was found to be 1.9%.
背景国际文献显示,患有糖尿病的儿童和青少年腹腔疾病(CD)的患病率在1-10%之间。非洲国家的患病率有限或未知。客观的目的是描述在南非比勒陀利亚Steve Biko学术医院儿科和成人糖尿病诊所就诊的所有1型糖尿病儿童和青少年CD的患病率。方法对2016年8月至2019年6月期间儿科和成人糖尿病诊所所有1型糖尿病儿童和青少年的档案进行了回顾性审查。在此期间,需要筛查和/或肠道活检的儿童也被前瞻性纳入。这项研究的背景是位于南非比勒陀利亚的三级转诊中心Steve Biko学术医院。腹腔筛查包括抗脱氨基醇溶蛋白抗体和抗组织谷氨酰胺转胺酶抗体(IgA和IgG)。所有活组织检查均由儿科胃肠病学家或经验丰富的儿科外科医生进行。后果共筛选了184份档案;132名患者符合纳入标准,但总共只有108名患者进行了腹腔筛查。108名患者中有11名(10.2%)CD抗体筛查呈阳性。11名血清学阳性患者中有9名进行了活检。在9例活组织检查中,有2例(22.2%)根据Marsh-Oberhuber分类为CD阳性。结论这项研究发现,在我们当地的南非1型糖尿病儿童人群中,血清学阳性CD的患病率为10.2%,而经活检证实的CD患病率为1.9%。
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引用次数: 2
Choreoathetosis and dystonia in a child with COVID‑19 and multisystem inflammatory syndrome 患有COVID - 19和多系统炎症综合征的儿童的舞蹈病和张力障碍
IF 0.4 Q4 PEDIATRICS Pub Date : 2021-12-31 DOI: 10.7196/sajch.2021.v15i4.1859
M. K. Mteshana, K. Naidoo, V. Rowjee, M. Hauptfleisch, Z. Dangor
Neurological complications of COVID-19 or multisystem inflammatory syndrome in children (MIS-C) are well described. We report an unusual presentation in a 9-year-old girl presenting with status epilepticus, who thereafter developed choreoathetosis and dystonia. She was initially managed with intravenous immunoglobulins and methylprednisolone for presumed autoimmune encephalitis. However, she tested positive for SARS-CoV-2 and met the clinical and laboratory criteria for MIS-C. She remained encephalopathic with abnormal movements and dystonia for 8 days from presentation but was discharged home with complete clinical recovery after 2 weeks.
COVID-19或儿童多系统炎症综合征(MIS-C)的神经系统并发症得到了很好的描述。我们报告一个不寻常的表现在一个9岁的女孩表现为癫痫持续状态,谁此后发展成舞蹈症和肌张力障碍。她最初接受静脉注射免疫球蛋白和甲基强的松龙治疗自身免疫性脑炎。然而,她的SARS-CoV-2检测呈阳性,符合MIS-C的临床和实验室标准。患者出现异常运动和肌张力障碍的脑病症状8天,2周后临床完全康复出院。
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引用次数: 0
Orchiepididymitis in a 14-year-old boy with concurrent SARS-CoV-2 infection 一名同时感染严重急性呼吸系统综合征冠状病毒2型的14岁男孩患上了兰花皮炎
IF 0.4 Q4 PEDIATRICS Pub Date : 2021-12-31 DOI: 10.7196/sajch.2021.v15i4.1869
M. Wronowski, W. Wożniak, M. Wanke-Rytt, K. Jazdzewski, Ernest P Kuchar, M. Kloc, J. Kubiak
The symptoms of SARS-CoV-2 infection and COVID-19 provoked by this virus are poorly described in children. Here we analyse a case of orchiepididymitis associated with COVID-19 in a 14-year-old boy. We discuss the possibility of SARS-CoV-2-associated testicular inflammation. This report strengthens the necessity for more in-depth study of the clinical presentation of paediatric COVID-19 and the potential association with non-respiratory symptoms
这种病毒引起的严重急性呼吸系统综合征冠状病毒2型感染和新冠肺炎的症状在儿童中描述不多。在此,我们分析了一例14岁男孩患上与新冠肺炎相关的睾丸炎。我们讨论了严重急性呼吸系统综合征冠状病毒2型相关睾丸炎症的可能性。本报告加强了对儿科新冠肺炎临床表现及其与非呼吸道症状的潜在关联进行更深入研究的必要性
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引用次数: 1
Early language development in children with autism (ages 3 - 5 years) in Bloemfontein, South Africa: A comparative study 南非布隆方丹自闭症儿童(3-5岁)早期语言发展的比较研究
IF 0.4 Q4 PEDIATRICS Pub Date : 2021-12-31 DOI: 10.7196/sajch.2021.v15i4.1836
N. Scholtz, S. Aveling, C. D. De Jager, C. Scheepers, D. Griessel, G. Joubert
Background. Autism is a developmental disorder, which presents during the childhood years, with social communication difficulties and signs of delay in early language development. Objectives. The aim of the study was to compare the early language development of children aged 3 - 5 years with a Diagnostic and Statistical Manual of Mental Disorders (DSM) V diagnosis of autism with that of children of the same age with typical early language development. The secondary aim was to determine if certain children with autism have better language development in the language to which they are exposed on television (English) than in their home language (Afrikaans). Methods. The Language Development Survey was translated into Afrikaans, modified and used as a questionnaire. For the control group, questionnaires were distributed at preschools and completed by the parents. For the sample group, questionnaires were distributed at the practice of a developmental paediatrician. Results. The median percentages of Afrikaans words used in all the categories were lower in the sample group than in the control group. More children in the sample group tended to speak English the best, use words not spoken at home, and imitate words and sounds in the incorrect context. Most of the parents of children in the sample group considered their child’s language development poor. Children in both groups watched television for long periods of time. Conclusions. Afrikaans-speaking children with autism have a poorer vocabulary in Afrikaans and used more English words than in the control group. The television exposure of children under the age of two years is high.
背景自闭症是一种发育障碍,出现在儿童时期,有社交困难和早期语言发展迟缓的迹象。目标。这项研究的目的是比较3-5岁儿童的早期语言发展与精神障碍诊断和统计手册(DSM)V诊断的自闭症与具有典型早期语言发展的同龄儿童的自闭症。次要目的是确定某些自闭症儿童在电视上接触的语言(英语)是否比在母语(南非荷兰语)中有更好的语言发展。方法。《语言发展调查》被翻译成南非荷兰语,经过修改后用作调查表。对照组在幼儿园发放问卷,由家长填写。对于样本组,在一名发育儿科医生的诊所分发了问卷。后果样本组在所有类别中使用的南非荷兰语单词的中位数百分比低于对照组。样本组中更多的孩子倾向于说最好的英语,使用家里没有说的单词,并在不正确的上下文中模仿单词和声音。样本组中大多数孩子的父母认为他们孩子的语言发展很差。两组的孩子都长时间看电视。结论。说南非荷兰语的自闭症儿童在南非荷兰语中的词汇量较差,使用的英语单词也比对照组多。两岁以下儿童在电视上的曝光率很高。
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引用次数: 0
Complications associated with central venous lines for paediatric oncology patients at Universitas Academic Hospital, Bloemfontein, from 1992 to 2018 1992年至2018年布隆方丹大学学术医院儿科肿瘤患者中心静脉线相关并发症
IF 0.4 Q4 PEDIATRICS Pub Date : 2021-12-31 DOI: 10.7196/sajch.2021.v15i4.1778
L. Mokone, P. Ndove, K. Magooa, K. Tsilo, R. Rampeta, E. Brits, G. Joubert
Background. Central venous access devices are associated with complications such as central-line infections and systemic sepsis. Objective. To determine the complication rates associated with central venous lines used to administer chemotherapy at the Paediatric Haematology Oncology Unit, Universitas Academic Hospital, Bloemfontein, from January 1992 to March 2018. Methods. A retrospective descriptive analysis of paediatric oncology patients who received intravenous catheterisation and were treated at the unit. Cases with incomplete data, age >16 years and treatment after 31 March 2018 were excluded. Results. Records of 293 Hickman lines were analysed. The median patient age was 64.7 months. Sepsis was noted in 13.3% of the cases; no in situ local complications were found in 62.5% of the lines. Of the 39 cases that presented with line sepsis, 23.1% showed no signs of systemic sepsis, whereas 61.5% were neutropenic and septic. In total, 190 patients had symptoms of systemic sepsis and accompanying neutropenia. Of these, 67.4% did not develop in situ line complications. Lines were removed mostly because the end of treatment had been reached (44.7%); line sepsis was noted as the reason for removal in only 16.3% of cases. Conclusion. Despite the study population having a high risk for infections because of a young age, a large proportion of haematological malignancies and surgical placement of Hickman lines, there was a low incidence of line sepsis complications. The special care taken intraoperatively and meticulous aseptic postoperative handling and maintenance are suggested as contributing to limited infective complications.
背景中心静脉接入装置与并发症有关,如中心线感染和全身败血症。客观的确定1992年1月至2018年3月在布隆方丹大学学院医院儿科血液肿瘤科进行化疗时使用的中心静脉导管的并发症发生率。方法。对接受静脉插管并在该单位接受治疗的儿科肿瘤学患者的回顾性描述性分析。排除数据不完整、年龄>16岁且在2018年3月31日之后接受治疗的病例。后果分析了293个希克曼品系的记录。患者的中位年龄为64.7个月。败血症占13.3%;62.5%的细胞系未发现原位局部并发症。在39例表现为系性败血症的病例中,23.1%没有系统性败血症的迹象,而61.5%是中性粒细胞减少和败血症。总共有190名患者出现全身性败血症症状并伴有中性粒细胞减少症。其中67.4%的患者没有出现原位生产线并发症。线条被去除主要是因为治疗已经结束(44.7%);只有16.3%的病例认为行败血症是切除的原因。结论尽管研究人群由于年龄较小、血液系统恶性肿瘤比例较大以及Hickman系的外科植入而具有较高的感染风险,但系败血症并发症的发生率较低。术中的特殊护理和细致的无菌术后处理和维护被认为有助于减少感染并发症。
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引用次数: 0
Sirenomelia with major cardiac anomalies 伴有严重心脏异常的鼻塞
IF 0.4 Q4 PEDIATRICS Pub Date : 2021-12-31 DOI: 10.7196/sajch.2021.v15i4.1815
R. Saggers, R. Charlton, P. Nongena, S. Velaphi
Sirenomelia is a rare and serious congenital anomaly characterised by fusion of the lower limbs, usually a single umbilical artery and malformations of the genitourinary and gastrointestinal tracts. In this report, we present clinical and radiological features, as well as autopsy findings, in a patient with sirenomelia diagnosed at the time of delivery. Major cardiac defects were observed, namely transposition of the great vessels and a hypoplastic left ventricle.
Sirenomelia是一种罕见且严重的先天性畸形,其特征是下肢融合,通常为单一脐动脉,泌尿生殖道和胃肠道畸形。在本报告中,我们介绍了一名分娩时诊断为父系母细胞增多症的患者的临床和放射学特征以及尸检结果。观察到主要的心脏缺陷,即大血管移位和左心室发育不全。
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引用次数: 0
A scoping review to identify the type and effect of hand hygiene interventions on the reduction of infectious diseases (including COVID-19) in preschool children 旨在确定手部卫生干预措施的类型及其对减少学龄前儿童传染病(包括COVID-19)的影响的范围综述
IF 0.4 Q4 PEDIATRICS Pub Date : 2021-12-31 DOI: 10.7196/sajch.2021.v15i4.1792
S. Lange, T. G. Bernard, N. Naicker
Background. Proper handwashing can reduce the burden of diseases related to hand hygiene (HH) and so contribute reducing under-5 mortality. Preschoolers can benefit from HH interventions by the burden of disease and absenteeism being reduced. Objective. To perform a scoping review of literature to assess the types and effectiveness of HH interventions at preschools, with a view to providing a guideline for appropriate interventions for South African facilities. Methods. A literature search was conducted through the PubMed database to identify relevant studies. An iterative screening process to focus the review allowed for information on the type and effectiveness of interventions to be collated. An updated PubMed search was conducted to determine whether any interventions related to COVID-19 at preschools could be included. Results. No additional studies relating to COVID-19 were found. Of the 305 studies identified during the initial search, only 12 fitted the specific search criteria. Of these, 10 studies showed improvements in HH-related indicators following the interventions. Only two studies used health education as an intervention, whereas the others included the supply of HH products (to varying extents) as part of the intervention. Conclusion. HH interventions appear successful in reducing diseases spread by poor HH, improving general HH practices and reducing absenteeism among preschoolers. Studies using innovative, entertaining methods of educating children have shown to be successful in improving handwashing techniques and decreasing microbial growth on children’s hands. HH interventions are suggested as an effective measure to improve HH during the COVID-19 pandemic
背景。正确洗手可减轻与手卫生有关的疾病负担,从而有助于降低5岁以下儿童死亡率。学龄前儿童可以从卫生保健干预措施中受益,因为疾病负担和缺勤减少了。目标。对文献进行范围审查,以评估幼儿园HH干预措施的类型和有效性,以期为南非设施提供适当干预措施的指导方针。方法。通过PubMed数据库进行文献检索,以确定相关研究。通过反复筛选过程集中审查,可以整理有关干预措施类型和有效性的信息。进行了更新的PubMed搜索,以确定是否可以包括与学龄前儿童COVID-19相关的任何干预措施。结果。未发现与COVID-19相关的其他研究。在最初的搜索过程中确定的305项研究中,只有12项符合特定的搜索标准。其中,有10项研究表明,采取干预措施后,卫生相关指标有所改善。只有两项研究使用健康教育作为干预措施,而其他研究(在不同程度上)将HH产品的供应作为干预措施的一部分。结论。健康护理干预措施似乎成功地减少了健康护理不良所传播的疾病,改善了健康护理的一般做法,并减少了学龄前儿童的缺勤。研究表明,使用创新、娱乐的方法教育儿童在改善洗手技术和减少儿童手上的微生物生长方面取得了成功。建议采取卫生干预措施,作为COVID-19大流行期间改善卫生状况的有效措施
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引用次数: 1
Utilisation of paediatric surgical theatres at the Chris Hani Baragwanath Academic Hospital, Johannesburg 约翰内斯堡Chris Hani Baragwanath学术医院儿科手术室的使用情况
IF 0.4 Q4 PEDIATRICS Pub Date : 2021-12-31 DOI: 10.7196/sajch.2021.v15i4.1774
S. Ford, N. Brink, N. Martin, S. Soares, B. Manicom, T. Mahadea, M. Reynolds, A. Grieve, J. Loveland, T. Gabler
Background. Optimal theatre utilisation is essential to reduce long waiting lists for elective surgeries and to increase cost-effective theatre operation. Utilisation rates well below the global benchmark of 80% have been reported for government hospitals in Johannesburg, South Africa (SA). Objective. To investigate utilisation of three paediatric theatres at the Chris Hani Baragwanath Academic Hospital (CHBAH) in Johannesburg. Methods. Surgery lists of the three theatres were reviewed for three one-week periods over a four-month study period. Preoperative, intraoperative and postoperative data were collected to create a timeline for each theatre and each surgical case, including reasons for cancellations, delays or expedited times. Results. A total of 152 surgeries were scheduled during the reviewed study period, of which 44 cases were cancelled. The utilisation rate was 59.8% across the three theatres combined, with individual rates calculated as 62.7%, 58.2% and 57.0% in the burns, general and neonatal theatres, respectively. The primary factor contributing to under-utilisation was early completion of the scheduled list. Surgery delays were mainly due to delays in transferring the patient to the theatre and between anaesthetic induction and the start of surgery. Conclusion. Utilisation of the paediatric theatres at CHBAH is below the ideal benchmark of 80%; however, utilisation was better than expected when compared with findings from other public-sector hospitals in SA. However, theatre efficiency was found to be very low and perhaps better explains the reasons for backlogs in paediatric surgeries at CHBAH.
背景最佳的手术室利用率对于减少择期手术的漫长等待名单和增加具有成本效益的手术室手术至关重要。据报道,南非约翰内斯堡政府医院的使用率远低于80%的全球基准。客观的调查约翰内斯堡Chris Hani Baragwanath学术医院(CHBAH)三个儿科手术室的使用情况。方法。在为期四个月的研究期间,对三个手术室的手术清单进行了为期三周的审查。收集术前、术中和术后数据,为每个手术室和每个手术病例创建时间表,包括取消、延迟或加快时间的原因。后果在审查研究期间,共安排了152例手术,其中44例被取消。三个手术室的使用率加起来为59.8%,烧伤、普通和新生儿手术室的个人使用率分别为62.7%、58.2%和57.0%。造成利用率不足的主要因素是提前完成预定清单。手术延误主要是由于将患者转移到手术室以及麻醉诱导和手术开始之间的延误。结论CHBAH儿科手术室的使用率低于80%的理想基准;然而,与南非其他公共部门医院的研究结果相比,利用率好于预期。然而,手术室的效率非常低,这也许更好地解释了CHBAH儿科手术积压的原因。
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引用次数: 1
Correlation between pulse oximetry and the clinical profile of children with acute lower respiratory tract infection 脉搏血氧测定与急性下呼吸道感染患儿临床特征的相关性研究
IF 0.4 Q4 PEDIATRICS Pub Date : 2021-12-31 DOI: 10.7196/sajch.2021.v15i4.1811
A. T. Chinawa, B. Chukwu, J. Chinawa, Obinna Chukwuebuka Nduagubam, A. Aronu
Background. Hypoxaemia is a common predictor of mortality and a potent marker of severe illness in children with acute lower respiratory tract infection (ALRTI). Objective. To determine the mean oxygen saturation (SpO2) in children with ALRTI and its correlation with selected clinical and anthropometric variables. Methods. A cross-sectional study of 178 children, aged between 2 months and 5 years, treated in two teaching hospitals in southeast Nigeria. All patients were assessed for ALRTI, focusing on their clinical profile and sociodemographic risk factors. Student’s t-test was used to compare means of discrete variables. Pearson correlation was used to express association between discrete variables and multiple regression was used to predict dependent variables. Results. Patients with severe ALRTI had significantly lower oxygen saturation (SpO2=89%) than those with mild disease (SpO2=95%) (p=0.001). A negative correlation was found between oxygen saturation and respiratory rate. Multiple regression analysis showed respiratory rate to be the only variable predicting oxygen saturation in children with ALRTI, with a negative association between the two variables. Conclusion. Low oxygen saturation is associated with decreased respiratory rate in children with ALRTI. Oxygen supplementation should always be considered in children with ALRTI, especially those with severe disease
背景低氧血症是急性下呼吸道感染(ALRTI)儿童死亡率的常见预测因素,也是严重疾病的有力标志。客观的确定ALRTI儿童的平均血氧饱和度(SpO2)及其与选定的临床和人体测量变量的相关性。方法。一项针对178名年龄在2个月至5岁之间的儿童的横断面研究,这些儿童在尼日利亚东南部的两家教学医院接受治疗。对所有患者进行ALRTI评估,重点关注他们的临床特征和社会人口统计学风险因素。学生t检验用于比较离散变量的平均值。Pearson相关用于表示离散变量之间的关联,多元回归用于预测因变量。后果严重ALRTI患者的血氧饱和度(SpO2=89%)明显低于轻度疾病患者(SpO2=95%)(p=0.001)。血氧饱和度与呼吸频率呈负相关。多元回归分析显示,呼吸频率是预测ALRTI儿童血氧饱和度的唯一变量,两个变量之间呈负相关。结论低氧饱和度与ALRTI儿童的呼吸频率降低有关。ALRTI儿童应始终考虑补充氧气,尤其是那些患有严重疾病的儿童
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引用次数: 1
Physical activity and sedentary behaviours during pregnancy are associated with neonatal size at birth 怀孕期间的体育活动和久坐行为与新生儿出生时的体型有关
IF 0.4 Q4 PEDIATRICS Pub Date : 2021-12-31 DOI: 10.7196/sajch.2021.v15i4.1827
A. Prioreschi, S. Wrottesley, S. Norris
Background. Pregnancy is a crucial time to examine modifiable maternal behaviours associated with neonatal outcomes so that preventative measures can be taken against childhood obesity. Objectives. This study aimed to examine the pathways through which maternal physical activity impacted neonatal size and body composition. Methods. A subsample of participants who had objectively measured physical activity data were included from a pregnancy cohort study. Sociodemographic data were collected at the first visit during pregnancy. Gestational weight gain (GWG) was calculated at each visit, and the presence of gestational diabetes, hypertension and HIV were assessed. Physical activity was measured using a hip-worn triaxial accelerometer, at 14 - 18 weeks’ and 29 - 33 weeks’ gestation. At delivery, gestational age, birthweight and length were measured and neonatal body composition was analysed. A structural equation model (SEM) was run with either weight-to-length ratio (WLR) or fat mass index (FMI) as the outcome. Results. A total of 84 participants were included in this study, and a subsample of neonates (n=45) also had FMI data. Most (66%) mothers presented as overweight or obese at their first visit, and gained on average 0.35 (19) kg per week. The SEM showed that only gestational age at delivery and sedentary time were positively associated with WLR. Step count was directly associated with GWG (ß=-0.02, p=0.01), and with gestational age (ß=0.16, p=0.04), and was therefore indirectly associated with decreased fetal abdominal circumference. Conclusion. This study showed that increasing daily step count and decreasing sedentary behaviour could have beneficial effects on maternal health as well as delivery outcomes and neonatal size.
背景。妊娠期是检查与新生儿结局相关的可改变的孕产妇行为的关键时期,以便采取预防措施防止儿童肥胖。目标。本研究旨在探讨通过母体体育活动影响新生儿大小和身体组成的途径。方法。从一项妊娠队列研究中纳入了具有客观测量体力活动数据的参与者的子样本。在怀孕期间第一次就诊时收集社会人口统计数据。在每次访问时计算妊娠期体重增加(GWG),并评估妊娠期糖尿病、高血压和HIV的存在。在妊娠14 - 18周和29 - 33周时,使用臀部佩戴的三轴加速度计测量身体活动。分娩时测量胎龄、出生体重和体长,分析新生儿体成分。以体重与长度比(WLR)或脂肪质量指数(FMI)为结果,运行结构方程模型(SEM)。结果。本研究共纳入84名参与者,新生儿亚样本(n=45)也有FMI数据。大多数(66%)母亲在第一次就诊时表现为超重或肥胖,每周平均体重增加0.35(19)公斤。扫描电镜显示,只有分娩胎龄和久坐时间与WLR呈正相关。步数与GWG直接相关(ß=-0.02, p=0.01),与胎龄直接相关(ß=0.16, p=0.04),因此与胎儿腹围减小间接相关。结论。这项研究表明,增加每日步数和减少久坐行为可能对孕产妇健康、分娩结果和新生儿体型产生有益影响。
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引用次数: 0
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South African Journal of Child Health
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