Pub Date : 2021-08-03DOI: 10.1007/s12018-021-09278-7
E. Galliera, L. Massaccesi, G. Banfi, E. De Vecchi, V. Ragone, M. C. Corsi Romanelli
{"title":"Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis","authors":"E. Galliera, L. Massaccesi, G. Banfi, E. De Vecchi, V. Ragone, M. C. Corsi Romanelli","doi":"10.1007/s12018-021-09278-7","DOIUrl":"https://doi.org/10.1007/s12018-021-09278-7","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"19 1","pages":"14 - 23"},"PeriodicalIF":1.8,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47936337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-07-31DOI: 10.1007/s12018-021-09277-8
Russell T Turner, Lara H Sattgast, Vanessa A Jimenez, Kathleen A Grant, Urszula T Iwaniec
Alcohol consumption is often reported to influence bone health in a dose-dependent manner where moderate alcohol intake is deemed beneficial and heavy drinking detrimental. However, this relationship may not be valid for individual alcohol consumers, as small quantities of alcohol can have detrimental skeletal effects and not all studies report clinically relevant bone loss with long-duration alcohol abuse. These discrepant findings suggest that factors beyond quantity of alcohol consumed contribute to the observed skeletal response. We propose that the interplay between intrinsic (e.g., age, sex, skeletal site) and extrinsic (e.g., age of onset of drinking, duration of drinking, comorbidities) factors influence the precise impact of alcohol consumption on bone health. In this review, we summarize literature reporting the effects of alcohol on the human skeleton. Based on the finding that alcohol alters the circulating levels of dozens of peptides shown to influence bone metabolism, we arrive at the conclusion that no single unifying mechanism adequately explains the diversity of reports or successfully predicts individuals most likely to be impacted favorably or unfavorably by alcohol consumption. We propose that a more holistic approach - in which drinking pattern and intrinsic factors are accounted for - is required to better understand and respond to the end organ effects of alcohol on the skeleton.
{"title":"Making Sense of the Highly Variable Effects of Alcohol on Bone.","authors":"Russell T Turner, Lara H Sattgast, Vanessa A Jimenez, Kathleen A Grant, Urszula T Iwaniec","doi":"10.1007/s12018-021-09277-8","DOIUrl":"10.1007/s12018-021-09277-8","url":null,"abstract":"<p><p>Alcohol consumption is often reported to influence bone health in a dose-dependent manner where moderate alcohol intake is deemed beneficial and heavy drinking detrimental. However, this relationship may not be valid for individual alcohol consumers, as small quantities of alcohol can have detrimental skeletal effects and not all studies report clinically relevant bone loss with long-duration alcohol abuse. These discrepant findings suggest that factors beyond quantity of alcohol consumed contribute to the observed skeletal response. We propose that the interplay between intrinsic (e.g., age, sex, skeletal site) and extrinsic (e.g., age of onset of drinking, duration of drinking, comorbidities) factors influence the precise impact of alcohol consumption on bone health. In this review, we summarize literature reporting the effects of alcohol on the human skeleton. Based on the finding that alcohol alters the circulating levels of dozens of peptides shown to influence bone metabolism, we arrive at the conclusion that no single unifying mechanism adequately explains the diversity of reports or successfully predicts individuals most likely to be impacted favorably or unfavorably by alcohol consumption. We propose that a more holistic approach - in which drinking pattern and intrinsic factors are accounted for - is required to better understand and respond to the end organ effects of alcohol on the skeleton.</p>","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"19 1","pages":"1-13"},"PeriodicalIF":2.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47801150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.1007/s12018-021-09279-6
M. Abed, F. Alassaf, M. Qazzaz, M. Alfahad, Mahmood H. M. Jasim
{"title":"Insights into the Perspective Correlation Between Vitamin D and Regulation of Hormones: Thyroid and Parathyroid Hormones","authors":"M. Abed, F. Alassaf, M. Qazzaz, M. Alfahad, Mahmood H. M. Jasim","doi":"10.1007/s12018-021-09279-6","DOIUrl":"https://doi.org/10.1007/s12018-021-09279-6","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"1 1","pages":"1-7"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-021-09279-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43661465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.1007/s12018-021-09275-w
D. Cici, A. Corrado, C. Rotondo, R. Colia, F. Cantatore
{"title":"Adipokines and Chronic Rheumatic Diseases: from Inflammation to Bone Involvement","authors":"D. Cici, A. Corrado, C. Rotondo, R. Colia, F. Cantatore","doi":"10.1007/s12018-021-09275-w","DOIUrl":"https://doi.org/10.1007/s12018-021-09275-w","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"1 1","pages":"1-14"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-021-09275-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45016869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.1007/s12018-021-09276-9
T. Anijs, I. Kouwert, N. Verdonschot, D. Janssen
{"title":"Towards a Standard Approach to Assess Tibial Bone Loss Following Total Knee Arthroplasty","authors":"T. Anijs, I. Kouwert, N. Verdonschot, D. Janssen","doi":"10.1007/s12018-021-09276-9","DOIUrl":"https://doi.org/10.1007/s12018-021-09276-9","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"1 1","pages":"1-15"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-021-09276-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44444463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-15DOI: 10.1007/s12018-020-09272-5
Supamit Ukarapong, Tossaporn Seeherunvong, G. Berkovitz
{"title":"Current and Emerging Therapies for Pediatric Bone Diseases","authors":"Supamit Ukarapong, Tossaporn Seeherunvong, G. Berkovitz","doi":"10.1007/s12018-020-09272-5","DOIUrl":"https://doi.org/10.1007/s12018-020-09272-5","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"18 1","pages":"31 - 42"},"PeriodicalIF":1.8,"publicationDate":"2020-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-020-09272-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42323099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-13DOI: 10.1007/s12018-020-09273-4
V. Nicolin, F. Costantinides, Erica Vettori, F. Berton, G. Marchesi, R. Rizzo, R. Di Lenarda
{"title":"Can Periodontal Disease Be Considered Linked to Obesity and Lipoinflammation? Mechanisms Involved in the Pathogenesis Occurrence","authors":"V. Nicolin, F. Costantinides, Erica Vettori, F. Berton, G. Marchesi, R. Rizzo, R. Di Lenarda","doi":"10.1007/s12018-020-09273-4","DOIUrl":"https://doi.org/10.1007/s12018-020-09273-4","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"18 1","pages":"43-49"},"PeriodicalIF":1.8,"publicationDate":"2020-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-020-09273-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47605210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-09DOI: 10.1007/s12018-020-09271-6
Namrata S. Jajoo, Anup U. Shelke, R. Bajaj
{"title":"Periodontitis and Rheumatoid Arthritis: the Common Thread","authors":"Namrata S. Jajoo, Anup U. Shelke, R. Bajaj","doi":"10.1007/s12018-020-09271-6","DOIUrl":"https://doi.org/10.1007/s12018-020-09271-6","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"1 1","pages":"1-13"},"PeriodicalIF":1.8,"publicationDate":"2020-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-020-09271-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46663957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-16DOI: 10.1007/s12018-020-09270-7
Hadis Ashrafizadeh, Mohadeseh Ashrafizadeh, A. A. Oroojan
{"title":"Type 2 Diabetes Mellitus and Osteoarthritis: the Role of Glucose Transporters","authors":"Hadis Ashrafizadeh, Mohadeseh Ashrafizadeh, A. A. Oroojan","doi":"10.1007/s12018-020-09270-7","DOIUrl":"https://doi.org/10.1007/s12018-020-09270-7","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"1 1","pages":"1-17"},"PeriodicalIF":1.8,"publicationDate":"2020-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-020-09270-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46545994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Even though inflammatory conditions are known to exert adverse effects on bone metabolism, there are no published data regarding SARS-CoV-2 infection and subsequent fracture risk. We present a brief review of the molecular mechanisms linking inflammatory diseases to increased fracture risk/osteoporosis and of the therapeutic strategies that can prevent bone resorption in patients with inflammatory disease, focusing on the RANK-RANKL system. We also make some considerations on gender differences in infection response and on their implications for survival and for the consequences of COVID-19. Several inflammatory cytokines, especially IL-1, IL-6, and TNF-α, stimulate osteoclast activity, favoring bone resorption through the RANK-RANKL system. Data from the previous SARS-CoV outbreak suggest that the present disease also has the potential to act directly on bone resorption units, although confirmation is clearly needed. Even though the available data are limited, the RANK-RANKL system may provide the best therapeutic target to prevent bone resorption after COVID-19 disease. Vitamin D supplementation in case of deficiency could definitely be beneficial for bone metabolism, as well as for the immune system. Supplementation of vitamin D in case of deficiency could be further advantageous. In COVID-19 patients, it would be useful to measure the bone metabolism markers and vitamin D. Targeting the RANK-RANKL system should be a priority, and denosumab could represent a safe and effective choice. In the near future, every effort should be made to investigate the fracture risk after SARS-CoV-2 infection.
尽管众所周知炎症会对骨代谢产生不利影响，但目前还没有关于 SARS-CoV-2 感染和后续骨折风险的公开数据。我们简要回顾了炎症性疾病与骨折风险/骨质疏松症增加之间的分子机制，以及可以防止炎症性疾病患者骨吸收的治疗策略，重点是 RANK-RANKL 系统。我们还对感染反应的性别差异及其对生存和 COVID-19 后果的影响进行了一些思考。几种炎症细胞因子，尤其是 IL-1、IL-6 和 TNF-α，可刺激破骨细胞的活性，通过 RANK-RANKL 系统促进骨吸收。上一次 SARS-CoV 爆发的数据表明，目前的疾病也有可能直接作用于骨吸收单位，但显然还需要证实。尽管现有数据有限，但 RANK-RANKL 系统可能是预防 COVID-19 疾病后骨吸收的最佳治疗目标。在缺乏维生素 D 的情况下补充维生素 D 肯定对骨代谢和免疫系统有益。在缺乏维生素 D 的情况下补充维生素 D 可能更有好处。针对 RANK-RANKL 系统的治疗应优先考虑，而地诺单抗可能是一种安全有效的选择。在不久的将来，应尽一切努力研究 SARS-CoV-2 感染后的骨折风险。
{"title":"Bone Metabolism in SARS-CoV-2 Disease: Possible Osteoimmunology and Gender Implications.","authors":"Gianmaria Salvio, Claudio Gianfelice, Francesca Firmani, Stefano Lunetti, Giancarlo Balercia, Gilberta Giacchetti","doi":"10.1007/s12018-020-09274-3","DOIUrl":"10.1007/s12018-020-09274-3","url":null,"abstract":"<p><p>Even though inflammatory conditions are known to exert adverse effects on bone metabolism, there are no published data regarding SARS-CoV-2 infection and subsequent fracture risk. We present a brief review of the molecular mechanisms linking inflammatory diseases to increased fracture risk/osteoporosis and of the therapeutic strategies that can prevent bone resorption in patients with inflammatory disease, focusing on the RANK-RANKL system. We also make some considerations on gender differences in infection response and on their implications for survival and for the consequences of COVID-19. Several inflammatory cytokines, especially IL-1, IL-6, and TNF-α, stimulate osteoclast activity, favoring bone resorption through the RANK-RANKL system. Data from the previous SARS-CoV outbreak suggest that the present disease also has the potential to act directly on bone resorption units, although confirmation is clearly needed. Even though the available data are limited, the RANK-RANKL system may provide the best therapeutic target to prevent bone resorption after COVID-19 disease. Vitamin D supplementation in case of deficiency could definitely be beneficial for bone metabolism, as well as for the immune system. Supplementation of vitamin D in case of deficiency could be further advantageous. In COVID-19 patients, it would be useful to measure the bone metabolism markers and vitamin D. Targeting the RANK-RANKL system should be a priority, and denosumab could represent a safe and effective choice. In the near future, every effort should be made to investigate the fracture risk after SARS-CoV-2 infection.</p>","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"18 4","pages":"51-57"},"PeriodicalIF":0.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38360919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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