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Mechanisms of action of general anaesthetic drugs 全身麻醉药物的作用机制
IF 0.3 Q4 ANESTHESIOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.mpaic.2025.11.004
Tom Bower, Thomas Clayton
The mechanism of action of general anaesthetic drugs is not fully understood, with many different theories proposed since the mid-1800s. The initial descriptions of anaesthetic agents disrupting the lipid bilayer of neuronal cell membranes has been replaced by current understanding that general anaesthetic drugs act upon specific ion channels within neuronal cell membranes to exert their effect. The most commonly used general anaesthetic drugs are believed to cause central nervous system depression through activation of the inhibitory γ-amino butyric acid type A (GABAA) receptors and inhibition of the excitatory N-methyl-d-aspartate (NMDA) receptors. There are a number of variants of GABAA receptor subunits which may be arranged in differing combinations, owing to the variability of the effects of anaesthetic agents on these receptors.
全身麻醉药物的作用机制尚不完全清楚,自19世纪中期以来提出了许多不同的理论。麻醉药破坏神经元细胞膜脂质双分子层的最初描述已被目前的理解所取代,即全身麻醉药作用于神经元细胞膜内的特定离子通道以发挥其作用。最常用的全身麻醉药物被认为是通过激活抑制性γ-氨基丁酸A型(GABAA)受体和抑制兴奋性n -甲基-d-天冬氨酸(NMDA)受体而引起中枢神经系统的抑制。由于麻醉剂对GABAA受体作用的可变性,GABAA受体亚基有许多变体,它们可能以不同的组合排列。
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引用次数: 0
Basic measurement concepts 基本测量概念
IF 0.3 Q4 ANESTHESIOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.mpaic.2025.11.005
Alexander T Vidouris, Ming Wilson
Modern anaesthesia relies upon reliable measurement of physiological parameters, with the parameter being measured known as the measurand. Advancements in technology mean that monitoring systems are faster, more sophisticated, more user friendly and able to be used during transfers; empowering clinicians to deliver increasingly safe care to patients. It is imperative that anaesthetists demonstrate a thorough understanding of the utility of these systems, their underlying principles, limitations and potential sources of error. Components of a measuring system include sensors, transducers, signal conditioning units, analogue to digital converters and displays. Processing of signals can include reducing noise, filtering, common mode rejection, amplification and conversion to a digital signal which allows display of data in real time and storage of data for review later. Performance of the system depends upon its accuracy, precision and linearity. They often behave as first- or second-order systems and are subject to systematic and random error which can include drift and hysteresis and often require calibration. This article aims to describe the concepts of basic measurement systems.
现代麻醉依赖于可靠的生理参数测量,被测量的参数被称为测量值。技术的进步意味着监测系统更快、更精密、更便于用户使用,并且能够在转移期间使用;使临床医生能够向患者提供越来越安全的护理。麻醉师必须对这些系统的效用、其基本原理、限制和潜在的错误来源有透彻的了解。测量系统的组件包括传感器、换能器、信号调节单元、模拟数字转换器和显示器。信号的处理可以包括降低噪声、滤波、共模抑制、放大和转换为数字信号,从而允许实时显示数据和存储数据以供以后审查。系统的性能取决于其精度、精度和线性度。它们通常表现为一阶或二阶系统,并受到系统和随机误差的影响,这些误差可能包括漂移和滞后,并且通常需要校准。本文旨在描述基本测量系统的概念。
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引用次数: 0
Obstructive sleep apnoea and anaesthesia 阻塞性睡眠呼吸暂停和麻醉
IF 0.3 Q4 ANESTHESIOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.mpaic.2025.10.014
Daniel J Kirkin, Atika Sabharwal, Jonathan Cousins
Obstructive sleep apnoea is an increasingly prevalent perioperative concern for anaesthetists worldwide. In the UK, there is estimated to be 8 million people with suspected obstructive sleep apnoea, but only 1.5 million that have been formally diagnosed. Obstructive sleep apnoea is associated with increased perioperative cardiopulmonary complications; however, clear and concise management guidance has been lacking. The Centre for Perioperative Care published user-friendly practical guidelines in 2025 summarizing key perioperative recommendations. Preoperative management should focus upon appropriate screening and risk-stratification using the STOP-BANG questionnaire. Although formal diagnosis via sleep studies may not be feasible for all, appropriate management pathways can be guided by STOP-BANG scores and clinical context. Preoperative optimization with continuous positive airway pressure therapy reduces postoperative complications and should be initiated where possible. Intraoperatively, locoregional techniques are preferred, and opioid-sparing analgesic strategies are recommended if general anaesthesia is necessary. There is an eightfold increase in airway management difficulties during induction of anaesthesia in patients with obstructive sleep apnoea, therefore risk reduction strategies should mirror those utilized for patients living with obesity. There remains limited evidence to guide the optimal care facility and duration of monitoring to reduce the risk of adverse postoperative respiratory events.
阻塞性睡眠呼吸暂停是世界各地麻醉师越来越普遍的围手术期问题。在英国,估计有800万人疑似患有阻塞性睡眠呼吸暂停症,但只有150万人得到了正式诊断。阻塞性睡眠呼吸暂停与围手术期心肺并发症的增加有关;然而,缺乏清晰、简明的管理指导。围手术期护理中心于2025年发布了用户友好的实用指南,总结了关键的围手术期建议。术前管理应侧重于使用STOP-BANG问卷进行适当的筛查和风险分层。虽然通过睡眠研究的正式诊断可能并不适用于所有人,但适当的管理途径可以通过STOP-BANG评分和临床背景来指导。术前优化持续气道正压治疗减少术后并发症,并应在可能的情况下开始。术中,局部技术是首选,如果需要全身麻醉,建议使用保留阿片类药物的镇痛策略。阻塞性睡眠呼吸暂停患者在麻醉诱导期间气道管理困难增加8倍,因此风险降低策略应与肥胖患者使用的策略相一致。指导最佳护理设施和监测时间以减少术后不良呼吸事件风险的证据仍然有限。
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引用次数: 0
Anaesthesia for ear surgery 耳外科麻醉
IF 0.3 Q4 ANESTHESIOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.mpaic.2025.10.018
Rachel L Smith, AE Louise McMurran, Patrick A Ward
Anaesthesia for ear surgery requires knowledge of the relevant anatomy and appreciation of the principal surgical requirements – a stationary patient and dry operating field intraoperatively to facilitate surgery; and, smooth emergence from anaesthesia at the end of surgery, to minimize complications. To achieve the optimum patient outcome, the anaesthetist must modify their anaesthetic technique, tailoring it to the individual patient and the underlying pathology, including employing intraoperative strategies to safely manipulate the patient's blood pressure and preserve facial nerve function, techniques to attenuate airway reflexes at emergence, and utilizing a multi-modal approach to provision of analgesia and postoperative nausea and vomiting prophylaxis. Crucially, the anaesthetist must be aware that many surgical procedures involving the ear are undertaken to preserve, improve or restore hearing function, such that careful preparation and meticulous perioperative care are essential in order to optimize outcome and to minimize complications.
耳部手术的麻醉需要具备相关解剖学知识和对主要手术要求的理解——术中病人要保持静止,操作区域要干燥,以方便手术;并且,手术结束时顺利脱离麻醉,尽量减少并发症。为了达到最佳的患者治疗效果,麻醉师必须调整麻醉技术,根据患者个体和潜在病理进行调整,包括术中采用安全控制患者血压和保持面神经功能的策略,在急诊时使用减轻气道反射的技术,以及利用多模式方法提供镇痛和术后恶心呕吐预防。至关重要的是,麻醉师必须意识到许多涉及耳朵的外科手术都是为了保护、改善或恢复听力功能,因此精心的准备和细致的围手术期护理对于优化结果和减少并发症是必不可少的。
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引用次数: 0
Self-assessment 自我评估
IF 0.3 Q4 ANESTHESIOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.mpaic.2025.10.022
Vijayanand Nadella
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引用次数: 0
Airway trauma 气道的创伤
IF 0.3 Q4 ANESTHESIOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.mpaic.2025.10.016
Kirsty Morrison, Euan Richardson, Simon Crawley
Airway trauma can be a life-threatening condition which poses significant challenges to clinicians, who may be presented with an anatomically, pathologically, physiologically and situationally difficult airway all within the same patient. Airway trauma is a highly variable condition, with its subsequent clinical management being influenced by the cause (such as blunt or penetrating trauma), the anatomical site of injury, as well as the presence of other life-threatening non-airway injuries in the polytrauma injured patient. The trauma team should comprise senior clinical decision-makers and they must rapidly identify the need for additional input from specialities such as ENT or maxillofacial surgery.
Early airway intervention is necessary when airway compromise is present and the multidisciplinary team must be vigilant for this eventuality, since rapid deterioration can occur. A structured approach to patients’ resuscitation, injury assessment and investigation(s) should be followed, in order to guide the most appropriate strategy for securing the airway. This should take into consideration the time-critical nature of injuries, the degree of patient cooperation (influencing the utility of awake airway management techniques) as well as the location/environment, provision of equipment and availability of appropriately trained personnel.
气道创伤是一种危及生命的疾病,对临床医生提出了重大挑战,他们可能会在同一患者身上出现解剖学、病理学、生理学和情境性困难的气道。气道创伤是一种高度可变的疾病,其随后的临床处理受到病因(如钝性或穿透性创伤)、损伤的解剖部位以及多发创伤患者存在其他危及生命的非气道损伤的影响。创伤小组应由高级临床决策者组成,他们必须迅速确定需要从耳鼻喉科或颌面外科等专科获得额外的投入。当出现气道损害时,早期气道干预是必要的,多学科团队必须对这种可能性保持警惕,因为可能会发生快速恶化。应遵循患者复苏、损伤评估和调查的结构化方法,以指导最合适的气道保护策略。这应考虑到损伤的时间紧迫性、患者的合作程度(影响清醒气道管理技术的效用)以及地点/环境、设备的提供和受过适当培训的人员的可用性。
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引用次数: 0
Anaesthesia for transoral robotic head and neck surgery 经口机器人头颈部手术的麻醉
IF 0.3 Q4 ANESTHESIOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.mpaic.2025.10.017
Sophie A Saul, Patrick A Ward
Oropharyngeal cancer is common and the incidence is rising globally. Current treatment modalities include chemotherapy, radiotherapy and surgery, alone or in combination. Transoral robotic surgery (TORS) is a minimally invasive surgical technique undertaken in patients that would likely otherwise require major open head and neck surgical resection necessitating invasive access procedures and associated with significant patient morbidity. While TORS can potentially offer advantages over more traditional treatment options, it provides unique challenges to the anaesthesia team, particularly around airway assessment and management, patient preparation and positioning, operating theatre ergonomics and patient postoperative requirements.
口咽癌很常见,全球发病率正在上升。目前的治疗方式包括单独或联合化疗、放疗和手术。经口机器人手术(TORS)是一种微创手术技术,适用于那些可能需要进行大的开放性头颈部手术切除,需要进行侵入性手术并伴有显著患者发病率的患者。虽然TORS可能比传统的治疗方案更有优势,但它给麻醉团队带来了独特的挑战,特别是在气道评估和管理、患者准备和定位、手术室人体工程学和患者术后要求方面。
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引用次数: 0
Tracheal intubation techniques in adults 成人气管插管技术
IF 0.3 Q4 ANESTHESIOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.mpaic.2025.10.013
Charles A Flanders, Sneh V Shah, Rajinder S Chaggar, Patrick A Ward
Tracheal intubation, the act of placing a breathing tube into the trachea, remains the gold standard in airway management – permitting oxygenation, positive pressure ventilation and protection from pulmonary aspiration. Traditionally, this has been achieved using a rigid laryngoscope to obtain a direct view of the glottis and guide tube placement in an anaesthetized, paralysed patient; however, there are now a number of indirect techniques that employ a range of optical technologies to improve visualization of airway structures and allow safe and effective tracheal intubation in both awake and anaesthetized patients. Whatever the chosen technique, thorough airway evaluation, comprehensive preparation and planning (including establishing a patient-specific airway management strategy), optimizing ergonomics and effective team-work remain essential components in achieving successful tracheal intubation and maintaining patient safety. Even with equipment advances, there is no substitute for high-quality training and practice with locally available devices. Tracheal intubation can still be unsuccessful and maintenance of adequate oxygenation must remain the priority; multiple repeated intubation attempts should be avoided.
气管插管,将一根呼吸管插入气管,仍然是气道管理的黄金标准——允许氧合,正压通气和防止肺误吸。传统上,这已经实现使用刚性喉镜获得声门的直接视图和引导管放置在麻醉,瘫痪的病人;然而,现在有一些间接技术,采用一系列光学技术来改善气道结构的可视化,并允许在清醒和麻醉的患者中安全有效的气管插管。无论选择何种技术,彻底的气道评估、全面的准备和规划(包括建立针对患者的气道管理策略)、优化人体工程学和有效的团队合作仍然是实现气管插管成功和维护患者安全的重要组成部分。即使有了先进的设备,也没有什么可以替代高质量的培训和当地可用设备的实践。气管插管仍然可能不成功,维持足够的氧合必须仍然是优先事项;应避免多次重复插管。
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引用次数: 0
Ear, nose and throat emergencies 耳鼻喉急症
IF 0.3 Q4 ANESTHESIOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.mpaic.2025.10.019
Dmitrijs Sokolovs
Ear, nose and throat emergencies are a diverse group of high-acuity conditions affecting all age groups, with the potential for rapid airway compromise. Successful management hinges on a multidisciplinary approach and an evidence-based airway management strategy. This review outlines contemporary approaches to important emergencies of the upper and lower airways, including the shift towards default videolaryngoscopy. It features updated strategies for managing critical conditions such as epiglottitis, deep neck space abscesses and paediatric airway obstruction, integrating new recommendations for oxygenation, human factors and the use of flexible bronchoscopy. The goal is to provide a robust framework for anaesthetists to optimize patient safety and outcomes.
耳鼻喉急症是影响所有年龄组的一组不同的高敏性疾病,有可能迅速损害气道。成功的管理取决于多学科方法和循证气道管理策略。这篇综述概述了当前处理上、下气道重要紧急情况的方法,包括转向默认的视频喉镜检查。它的特点是处理会厌炎、深颈间隙脓肿和儿科气道阻塞等危重疾病的最新策略,整合了氧合、人为因素和柔性支气管镜检查使用的新建议。目标是为麻醉师提供一个健全的框架,以优化患者的安全和结果。
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引用次数: 0
Front of neck airways 颈部前气道
IF 0.3 Q4 ANESTHESIOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.mpaic.2025.10.020
Alexia Paolineli, Dave Vedage, John Myatt
Front of neck airway (FONA) plays a critical role in both elective and emergency airway management and is associated with significant morbidity and mortality. This article reviews key anatomical considerations, indications for FONA, and the various techniques used to secure an airway via the anterior neck, including surgical, percutaneous and cricothyroidotomy approaches. It also addresses the management of tracheostomies and laryngectomies, emergency airway algorithms, ultrasound-guided identification of the cricothyroid membrane and complications such as expanding neck haematomas. With a focus on adult patients, the article aims to raise awareness, consolidate essential guidance and improve the safety profile of FONA through education, standardization of care and familiarity with emergency protocols.
颈前气道(FONA)在择期和急诊气道管理中都起着关键作用,并与显著的发病率和死亡率相关。这篇文章回顾了FONA的主要解剖学注意事项,指征,以及用于通过前颈部固定气道的各种技术,包括手术,经皮和环甲状软骨切开术。它还涉及气管切开术和喉切除术的管理,紧急气道算法,超声引导环甲膜的识别和并发症,如颈部血肿扩大。本文以成人患者为研究对象,旨在通过教育、规范化护理和熟悉应急方案,提高对FONA的认识,巩固基本指导,并改善其安全性。
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引用次数: 0
期刊
Anaesthesia and Intensive Care Medicine
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