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Utilization of apitherapy in allergic asthma: A systematic review of clinical and preclinical studies. 在过敏性哮喘中使用哮喘治疗法:临床和临床前研究的系统回顾。
IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-04-30 eCollection Date: 2024-10-01 DOI: 10.4103/tcmj.tcmj_233_23
Nicolas Daniel Widjanarko, Jonathan Christianto Subagya, Josephine Immanuel Maksi, Felicia Grizelda Suryatenggara, Sharon Claudia Ethelyn Sihole

Objectives: This systematic review aimed to summarize the benefit of apitherapy in human and animal models of asthma.

Materials and methods: The procedures in this review were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 protocol, where MEDLINE, ProQuest, and EBSCOhost databases were used to obtain eligible studies dating to 2023. Furthermore, the risk of bias was assessed using Risk of Bias Tool 2.0 (RoB-2) for randomized-control trials and Systematic Review Centre for Laboratory Animal Experimentation's RoB for animal studies.

Results: A total of 12 studies were included in the review based on the predetermined eligibility criteria, consisting of 4 human and 8 animal model reports. Among the four human studies, two had a low risk, while the other two had some concerns of bias. In the case of eight animal model of asthma, a total of three domains had a high risk of bias. Moreover, the anti-inflammatory properties of apitherapy were demonstrated by its capacity to inhibit NF-κB, nuclear factor of activated T cells, and IgE antibodies, leading to decreased production of tumor necrosis factor-α, interleukin-2 (IL-2), IL-6, and IL-8, and an increase in IL-10 levels. These beneficial effects were reported to be associated with improvements in clinical manifestations and lung function parameters in human subjects. The use of apitherapy was also related to the restoration of airway structure, and reduction of inflammatory cell infiltration, epithelial thickness, and mucus secretion in lung tissue of animal model of asthma.

Conclusion: Based on the results, apitherapy was effective in improving asthma symptoms and reducing inflammation in human and animal models of asthma.

目的:本系统综述旨在总结哮喘治疗对人类和动物模型的益处:本综述根据《2020年系统综述和荟萃分析首选报告项目》(Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 protocol)执行,使用MEDLINE、ProQuest和EBSCOhost数据库获取2023年前符合条件的研究。此外,随机对照试验采用偏倚风险工具 2.0(RoB-2)评估偏倚风险,动物研究采用实验室动物实验系统综述中心的 RoB 评估偏倚风险:根据预先确定的资格标准,共有 12 项研究被纳入审查范围,其中包括 4 项人体研究和 8 项动物模型报告。在 4 项人体研究中,有 2 项风险较低,而另外 2 项则存在一些偏倚问题。在 8 个哮喘动物模型中,共有 3 个领域存在高偏倚风险。此外,抗哮喘疗法的抗炎特性还体现在它能够抑制 NF-κB、活化 T 细胞核因子和 IgE 抗体,从而减少肿瘤坏死因子-α、白细胞介素-2(IL-2)、IL-6 和 IL-8 的产生,并提高 IL-10 的水平。据报道,这些有益效果与人体临床表现和肺功能参数的改善有关。哮喘动物模型肺组织中的炎症细胞浸润、上皮厚度和粘液分泌减少也与使用哮喘治疗法恢复气道结构有关:结论:根据研究结果,气道疗法能有效改善人类和动物哮喘模型的哮喘症状并减轻炎症反应。
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引用次数: 0
An Apriori algorithm-based association rule analysis to identify acupoint combinations for treating uremic pruritus. 基于 Apriori 算法的关联规则分析,确定治疗尿毒症瘙痒症的穴位组合。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-26 eCollection Date: 2024-04-01 DOI: 10.4103/tcmj.tcmj_217_23
Ping-Hsun Lu, Chien-Cheng Lai, Ling-Ya Chiu, I-Hsin Lin, Chih-Chin Iou, Po-Hsuan Lu

Objective: Uremic pruritus (UP) is a prevalent and troublesome condition affecting individuals with end-stage renal failure, which results in intense pruritus, depression, as well as poor quality of sleep, significantly impacting their quality of life. According to previous studies, acupuncture and acupoint stimulation have been shown to provide additional benefits in treating UP in dialysis patients. In addition, using acupoints combination may yield superior effectiveness compared to utilizing a singular acupoint. To investigate the potential correlations between acupoint combinations, an association-rule analysis was employed.

Materials and methods: Apriori algorithms stand out as highly potent techniques for identifying associations in databases; this study utilized an association rule mining to examine the association rules of key acupoint groupings that could be employed for treating UP.

Results: The analysis utilized information derived from the meta-analysis encompassing 40 randomized controlled trials that used acupuncture to treat UP. In total, 64 acupoints were analyzed, and 71 association rules were found. The following acupoint combinations: Auricular shenmen (TF4), Quchi (LI11), and Geshu (BL17); Auricular heart (Extra14), Sanyinjiao (SP6), and Auricular lung (CO14); and Auricular heart (Extra14), Xuehai (SP10), and Auricular lung (CO14) showed the strongest associations.

Conclusion: Acupoints involving Auricular shenmen (TF4), Quchi (LI11), Geshu (BL17), Auricular heart (Extra14), Sanyinjiao (SP6), Auricular lung (CO14), and Xuehai (SP10) can be regarded as the core combination of acupuncture points for managing UP.

目的尿毒症瘙痒症(Uremic pruritus,UP)是终末期肾衰竭患者普遍存在的一种令人头疼的病症,会导致剧烈瘙痒、抑郁以及睡眠质量差,严重影响患者的生活质量。以往的研究表明,针灸和穴位刺激对治疗透析患者的瘙痒症有额外的益处。此外,与单个穴位相比,组合使用穴位可能会产生更好的疗效。为了研究穴位组合之间的潜在相关性,我们采用了关联规则分析法:Apriori算法是识别数据库中关联的高效技术;本研究利用关联规则挖掘法来研究可用于治疗UP的关键穴位组合的关联规则:该分析利用了荟萃分析(meta-analysis)中的信息,荟萃分析涵盖了40项使用针灸治疗UP的随机对照试验。共分析了 64 个穴位,发现了 71 条关联规则。以下是穴位组合:心包经(TF4)、曲池(LI11)和尺泽(BL17);心包经(Extra14)、三阴交(SP6)和肺俞(CO14);心包经(Extra14)、学海(SP10)和肺俞(CO14)的关联性最强:结论:耳穴神门(TF4)、曲池(LI11)、合谷(BL17)、心包经(Extra14)、三阴交(SP6)、肺俞(CO14)和学海(SP10)可视为调理 UP 的核心穴位组合。
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引用次数: 0
Esophageal motor abnormalities in gastroesophageal reflux disorders. 胃食管反流病的食管运动异常。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-26 eCollection Date: 2024-04-01 DOI: 10.4103/tcmj.tcmj_209_23
Wei-Yi Lei, Chih-Hsun Yi, Tso-Tsai Liu, Jui-Sheng Hung, Ming-Wun Wong, Chien-Lin Chen

Gastroesophageal reflux disease (GERD), a prevalent condition with multifactorial pathogenesis, involves esophageal motor dysmotility as a key contributing factor to its development. When suspected GERD patients have an inadequate response to proton-pump inhibitor (PPI) therapy and normal upper endoscopy results, high-resolution manometry (HRM) is utilized to rule out alternative diagnosis such as achalasia spectrum disorders, rumination, or supragastric belching. At present, HRM continues to provide supportive evidence for diagnosing GERD and determining the appropriate treatment. This review focuses on the existing understanding of the connection between esophageal motor findings and the pathogenesis of GERD, along with the significance of esophageal HRM in managing GERD patients. The International GERD Consensus Working Group introduced a three-step method, assessing the esophagogastric junction (EGJ), esophageal body motility, and contraction reserve with multiple rapid swallow (MRS) maneuvers. Crucial HRM abnormalities in GERD include frequent transient lower esophageal sphincter relaxations, disrupted EGJ, and esophageal body hypomotility. Emerging HRM metrics like EGJ-contractile integral and innovative provocative maneuver like straight leg raise have the potential to enhance our understanding of factors contributing to GERD, thereby increasing the value of HRM performed in patients who experience symptoms suspected of GERD.

胃食管反流病(GERD)是一种多因素致病的常见病,食管运动失调是其发病的关键因素。当疑似胃食管反流病患者对质子泵抑制剂(PPI)治疗反应不佳且上内镜检查结果正常时,可利用高分辨率测压法(HRM)排除贲门失弛缓症、反刍或胃上嗳气等其他诊断。目前,高分辨率测压法继续为诊断胃食管反流病和确定适当的治疗方法提供支持性证据。本综述重点介绍食管运动检查结果与胃食管反流病发病机制之间联系的现有认识,以及食管 HRM 在管理胃食管反流病患者方面的意义。国际胃食管反流病共识工作组引入了一种三步法,通过多次快速吞咽 (MRS) 操作评估食管胃交界处 (EGJ)、食管体运动和收缩储备。胃食管反流病的关键 HRM 异常包括频繁的一过性食管下括约肌松弛、EGJ 中断和食管体运动减弱。新出现的 HRM 指标(如 EGJ 收缩积分)和创新的挑衅性操作(如直腿抬高)有可能加深我们对导致胃食管反流病的因素的了解,从而提高对出现疑似胃食管反流病症状的患者进行 HRM 的价值。
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引用次数: 0
Neuromodulation techniques in poststroke motor impairment recovery: Efficacy, challenges, and future directions. 神经调控技术在中风后运动障碍恢复中的应用:疗效、挑战和未来方向。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-26 eCollection Date: 2024-04-01 DOI: 10.4103/tcmj.tcmj_247_23
Xiang-Ling Huang, Ming-Yung Wu, Ciou-Chan Wu, Lian-Cing Yan, Mei-Huei He, Yu-Chen Chen, Sheng-Tzung Tsai

Cerebrovascular accidents, also known as strokes, represent a major global public health challenge and contribute to substantial mortality, disability, and socioeconomic burden. Multidisciplinary approaches for poststroke therapies are crucial for recovering lost functions and adapting to new limitations. This review discusses the potential of neuromodulation techniques, repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation, spinal cord stimulation (SCS), vagus nerve stimulation (VNS), and deep brain stimulation (DBS), as innovative strategies for facilitating poststroke recovery. Neuromodulation is an emerging adjunct to conventional therapies that target neural plasticity to restore lost function and compensate for damaged brain areas. The techniques discussed in this review have different efficacies in enhancing neural plasticity, optimizing motor recovery, and mitigating poststroke impairments. Specifically, rTMS has shown significant promise in enhancing motor function, whereas SCS has shown potential in improving limb movement and reducing disability. Similarly, VNS, typically used to treat epilepsy, has shown promise in enhancing poststroke motor recovery, while DBS may be used to improve poststroke motor recovery and symptom mitigation. Further studies with standardized protocols are warranted to elucidate the efficacy of these methods and integrate them into mainstream clinical practice to optimize poststroke care.

脑血管意外(又称中风)是全球公共卫生面临的一项重大挑战,造成大量死亡、残疾和社会经济负担。脑卒中后治疗的多学科方法对于恢复丧失的功能和适应新的限制至关重要。本综述讨论了神经调控技术、重复经颅磁刺激(rTMS)、经颅直流电刺激、脊髓刺激(SCS)、迷走神经刺激(VNS)和脑深部刺激(DBS)作为促进脑卒中后康复的创新策略的潜力。神经调控是传统疗法的新兴辅助手段,以神经可塑性为目标,恢复丧失的功能并补偿受损的脑区。本综述中讨论的技术在增强神经可塑性、优化运动恢复和减轻卒中后损伤方面具有不同的功效。具体来说,经颅磁刺激在增强运动功能方面显示出巨大的潜力,而 SCS 则在改善肢体运动和减少残疾方面显示出潜力。同样,通常用于治疗癫痫的 VNS 在促进脑卒中后运动恢复方面也显示出了前景,而 DBS 则可用于改善脑卒中后运动恢复和症状缓解。为了阐明这些方法的疗效并将其纳入主流临床实践,优化卒中后护理,有必要进一步开展标准化方案研究。
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引用次数: 0
Protective effects of Jing-Si-herbal-tea in inflammatory cytokines-induced cell injury on normal human lung fibroblast via multiomic platform analysis. 通过多组学平台分析京四药茶对炎症细胞因子诱导的正常人肺成纤维细胞损伤的保护作用
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-26 eCollection Date: 2024-04-01 DOI: 10.4103/tcmj.tcmj_267_23
Chien-Hao Wang, Jai-Sing Yang, Chao-Jung Chen, San-Hua Su, Hsin-Yuan Yu, Yu-Ning Juan, Yu-Jen Chiu, Tsung-Jung Ho

Objectives: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were investigated in cellular damage mediated by pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, on normal human lung fibroblast by multiomic platform analysis.

Materials and methods: The in silico high-throughput target was analyzed using pharmacophore models by BIOVIA Discovery Studio 2022 with ingenuity pathway analysis software. To assess cell viability, the study utilized the MTT assay technique. In addition, the IncuCyte S3 ZOOM System was implemented for the continuous monitoring of cell confluence of JSHT-treated cytokine-injured HEL 299 cells. Cytokine concentrations were determined using a Quantibody Human Inflammation Array. Gene expression and signaling pathways were determined using next-generation sequencing.

Results: In silico high-throughput target analysis of JSHT revealed ingenuity in canonical pathways and their networks. Glucocorticoid receptor signaling is a potential signaling of JSHT. The results revealed protective effects against the inflammatory cytokines on JSHT-treated HEL 299 cells. Transcriptome and network analyses revealed that induction of helper T lymphocytes, TNFSF12, NFKB1-mediated relaxin signaling, and G-protein coupled receptor signaling play important roles in immune regulatory on JSHT-treated cytokine-injured HEL 299 cells.

Conclusion: The findings from our research indicate that JSHT holds promise as a therapeutic agent, potentially offering advantageous outcomes in treating virus infections through various mechanisms. Furthermore, the primary bioactive components in JSHT justify extended research in antiviral drug development, especially in the context of addressing coronavirus.

目的:通过多组学平台分析,研究京四凉茶对白细胞介素-1β、IL-6和肿瘤坏死因子-α等促炎细胞因子介导的正常人肺成纤维细胞损伤的保护作用及相关机制:通过 BIOVIA Discovery Studio 2022 和 ingenuity pathway analysis 软件,利用药效模型对高通量靶点进行了硅学分析。为了评估细胞活力,研究采用了 MTT 检测技术。此外,IncuCyte S3 ZOOM 系统用于连续监测经 JSHT 处理的细胞因子损伤 HEL 299 细胞的细胞融合度。使用定量抗体人类炎症阵列测定细胞因子浓度。基因表达和信号通路通过新一代测序测定:结果:对JSHT的高通量靶标分析显示了典型通路及其网络的独创性。糖皮质激素受体信号传导是 JSHT 的潜在信号传导途径。结果显示,JSHT对处理过的HEL 299细胞具有抗炎细胞因子的保护作用。转录组和网络分析显示,辅助T淋巴细胞诱导、TNFSF12、NFKB1介导的松弛素信号转导和G蛋白偶联受体信号转导在JSHT处理的细胞因子损伤的HEL 299细胞的免疫调节中发挥重要作用:我们的研究结果表明,JSHT 有望成为一种治疗剂,通过各种机制治疗病毒感染,可能会产生良好的效果。此外,JSHT 中的主要生物活性成分证明有理由在抗病毒药物开发方面进行更广泛的研究,尤其是在应对冠状病毒方面。
{"title":"Protective effects of Jing-Si-herbal-tea in inflammatory cytokines-induced cell injury on normal human lung fibroblast <i>via</i> multiomic platform analysis.","authors":"Chien-Hao Wang, Jai-Sing Yang, Chao-Jung Chen, San-Hua Su, Hsin-Yuan Yu, Yu-Ning Juan, Yu-Jen Chiu, Tsung-Jung Ho","doi":"10.4103/tcmj.tcmj_267_23","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_267_23","url":null,"abstract":"<p><strong>Objectives: </strong>The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were investigated in cellular damage mediated by pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, on normal human lung fibroblast by multiomic platform analysis.</p><p><strong>Materials and methods: </strong>The <i>in</i> <i>silico</i> high-throughput target was analyzed using pharmacophore models by BIOVIA Discovery Studio 2022 with ingenuity pathway analysis software. To assess cell viability, the study utilized the MTT assay technique. In addition, the IncuCyte S3 ZOOM System was implemented for the continuous monitoring of cell confluence of JSHT-treated cytokine-injured HEL 299 cells. Cytokine concentrations were determined using a Quantibody Human Inflammation Array. Gene expression and signaling pathways were determined using next-generation sequencing.</p><p><strong>Results: </strong><i>In</i> <i>silico</i> high-throughput target analysis of JSHT revealed ingenuity in canonical pathways and their networks. Glucocorticoid receptor signaling is a potential signaling of JSHT. The results revealed protective effects against the inflammatory cytokines on JSHT-treated HEL 299 cells. Transcriptome and network analyses revealed that induction of helper T lymphocytes, TNFSF12, NFKB1-mediated relaxin signaling, and G-protein coupled receptor signaling play important roles in immune regulatory on JSHT-treated cytokine-injured HEL 299 cells.</p><p><strong>Conclusion: </strong>The findings from our research indicate that JSHT holds promise as a therapeutic agent, potentially offering advantageous outcomes in treating virus infections through various mechanisms. Furthermore, the primary bioactive components in JSHT justify extended research in antiviral drug development, especially in the context of addressing coronavirus.</p>","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"36 2","pages":"152-165"},"PeriodicalIF":1.5,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11025590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advancements in hematopoietic stem cell transplantation in Taiwan. 台湾造血干细胞移植的最新进展。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-26 eCollection Date: 2024-04-01 DOI: 10.4103/tcmj.tcmj_276_23
Chi-Cheng Li, Xavier Cheng-Hong Tsai, Wei-Han Huang, Tso-Fu Wang

Hematopoietic stem cell transplantation (HSCT) can cure malignant and nonmalignant hematological disorders. From 1983 to 2022, Taiwan performed more than 10,000 HSCT transplants. The Taiwan Blood and Marrow Transplantation Registry collects clinical information to gather everyone's experience and promote the advances of HSCT in Taiwan to gather everyone's experience and promote advances of HSCT in Taiwan. Compared with matched sibling donors, transplants from matched unrelated donors exhibited a trend of superior survival. In Taiwan, transplant donors showed remarkable growth from unrelated (24.8%) and haploidentical (10.5%) donors. The number of older patients (17.4%; aged ≥61 years) who underwent transplantation has increased markedly. This review summarizes several significant developments in HSCT treatment in Taiwan. First, the use of Anti-thymocyte globulin (ATG) and intravenous busulfan regimens were important risk factors for predicting hepatic sinusoidal obstruction syndrome. Second, a new, machine learning-based risk prediction scoring system for posttransplantation lymphoproliferative disorder has identified five risk factors: aplastic anemia, partially mismatched related donors, fludarabine use, ATG use, and acute skin graft-versus-host disease. Third, although the incidence of idiopathic pneumonia syndrome was low (1.1%), its mortality rate was high (58.1%). Fourth, difficult-to-treat mantle cell and T-cell lymphomas treated with autologous HSCT during earlier remission had higher survival rates. Fifth, treatment of incurable multiple myeloma with autologous HSCT showed a median progression-free survival and overall survival of 46.5 and 70.4 months, respectively. Sixth, different haploidentical transplantation strategies were compared. Seventh, caution should be taken in administering allogeneic HSCT treatment in older patients with myeloid leukemia with a Charlson Comorbidity Index ≥3 because of a higher risk of nonrelapse mortality.

造血干细胞移植(HSCT)可以治疗恶性和非恶性血液病。从 1983 年到 2022 年,台湾共进行了 10,000 多例造血干细胞移植手术。台湾造血干细胞移植登记中心收集临床资料,收集大家的经验,促进台湾造血干细胞移植的发展。与匹配的同胞捐献者相比,匹配的非亲属捐献者的移植存活率呈上升趋势。在台湾,来自非血缘关系(24.8%)和单倍体(10.5%)供体的移植供体显著增加。接受移植的老年患者(17.4%;年龄≥61 岁)人数显著增加。本综述总结了台湾造血干细胞移植治疗的几项重大进展。首先,使用抗胸腺细胞球蛋白(ATG)和静脉注射硫酸氢钠方案是预测肝窦阻塞综合征的重要风险因素。第二,一种新的、基于机器学习的移植后淋巴组织增生性疾病风险预测评分系统确定了五个风险因素:再生障碍性贫血、部分不匹配的相关供者、氟达拉滨的使用、ATG的使用和急性皮肤移植物抗宿主病。第三,虽然特发性肺炎综合征的发病率很低(1.1%),但死亡率却很高(58.1%)。第四,在早期缓解期接受自体造血干细胞移植治疗的难治套细胞淋巴瘤和T细胞淋巴瘤的存活率较高。第五,用自体造血干细胞移植治疗无法治愈的多发性骨髓瘤,无进展生存期和总生存期的中位数分别为 46.5 个月和 70.4 个月。第六,比较了不同的单倍体移植策略。第七,对查尔森综合症指数≥3的老年髓性白血病患者进行异基因造血干细胞移植治疗时应谨慎,因为非复发死亡风险较高。
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引用次数: 0
Association of HLA-C*07:359 with HLA-A, -B, and -DRB1 alleles in Taiwanese. 台湾人的 HLA-C*07:359 与 HLA-A、-B 和 -DRB1 等位基因的关系。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-26 eCollection Date: 2024-04-01 DOI: 10.4103/tcmj.tcmj_288_23
Kuo-Liang Yang, Py-Yu Lin
<p><strong>Objectives: </strong>It is thought that Taiwanese indigenous people were the "first people" to populate Taiwan (Formosa) having been there for over 5000 years, preceding the Dutch colonization (from 1624 to 1662) and Spanish colonization (from 1626 to 1642). Taiwan's indigenes, represented by Austronesian language speakers, currently constitute approximately 2% of the total population in Taiwan. It is unknown whether they evolved from Taiwan's Paleolithic or Neolithic cultures, arrived during or after the Neolithic period from China or Southeast Asia or both. HLA studies on the Taiwanese indigenous population have found several intriguing genetic information showing one or two relatively frequently observed alleles and a small number of relatively less frequently observed ones. We report here a relatively frequently observed HLA-C*07:359 allele in the Taiwanese indigenous population, its linkage with HLA-B*39:01, and its probable associated HLA haplotype in two Taiwanese indigenous families. HLA-C*07:359 is a rarely observed allele in the HLA-C locus in the world populations. The objective of this study is to report the allele HLA-C*07:359 that is more frequently found in the Taiwanese population, especially in the Taiwanese indigenous people, to demonstrate that it has a close linkage with HLA-B*39:01 allele in the HLA-B locus and to show the plausible deduced HLA-A-C-B-DRB1-DQB1 haplotypes in association with HLA-C*07:359 in two families of Taiwanese indigenous unrelated individuals.</p><p><strong>Materials and methods: </strong>The samples were peripheral whole blood, with dipotassium ethylenediaminetetraacetic acid and/or acid citrate dextrose anticoagulation additives. The sequence-based typing method was employed to confirm the low incidence of the allele of HLA-C*07:359 observed in Taiwanese. Polymerase chain reaction was carried out to amplify exons 2, 3, and 4 of the HLA-A,-B,-C,-DRB1 and-DQB1 loci with group-specific primer sets. Amplicons were sequenced using the BigDye Terminator Cycle Sequencing Ready Reaction Kit in both directions according to the manufacturer's protocol.</p><p><strong>Results: </strong>C*07:359 is an uncommon allele in the HLA-C locus in the world general population, according to our literature review. However, in this study, it is observed in the general Taiwanese population (frequency 0.41%), especially in the Taiwanese indigenous people at a frequency of 0.23%. In addition, we deduced two probable HLA haplotypes in association with C*07:359 in two indigenous families: A*24:02-C*07:359-B*39:01-DRB1*04:36 and A*24:02-C*07:359-B*39:01-DRB1*04:04.</p><p><strong>Conclusion: </strong>The two deduced HLA haplotypes associated with the uncommon C*07:359 allele that we report here are valuable for HLA tissue typing laboratories for reference purposes and for stem cell transplantation donor search coordinators to determine the likelihood of finding compatible donors in unrelated bone marrow donor registries fo
目的:台湾原住民被认为是居住在台湾(福尔摩沙)的 "第一人",在荷兰殖民(1624 年至 1662 年)和西班牙殖民(1626 年至 1642 年)之前,台湾原住民已在台湾居住了 5000 多年。以南岛语为代表的台湾原住民目前约占台湾总人口的 2%。他们是由台湾旧石器时代或新石器时代的文化演变而来,还是在新石器时代期间或之后从中国或东南亚或两者兼而有之而来,目前尚不清楚。对台湾原住民进行的 HLA 研究发现了一些耐人寻味的遗传信息,显示出一到两个相对频繁出现的等位基因和少量相对较少出现的等位基因。在此,我们报告了在台湾原住民中观察到的相对较多的 HLA-C*07:359 等位基因、它与 HLA-B*39:01 的联系以及在两个台湾原住民家庭中可能存在的相关 HLA 单倍型。HLA-C*07:359是HLA-C位点上的一个等位基因,在世界人群中很少见。本研究的目的是报告在台湾人群中,尤其是在台湾原住民中发现较多的等位基因 HLA-C*07:359,证明它与 HLA-B 位点上的 HLA-B*39:01 等位基因有密切联系,并在两个台湾原住民非亲缘关系的家庭中显示与 HLA-C*07:359 相关的 HLA-A-C-B-DRB1-DQB1 单倍型:样本为外周全血,添加乙二胺四乙酸二钾和/或柠檬酸葡萄糖抗凝剂。采用基于序列的分型方法,以确认在台湾人中观察到的 HLA-C*07:359 等位基因的低发生率。聚合酶链式反应使用特定组别的引物组扩增 HLA-A,-B,-C,-DRB1 和 DQB1 基因座的 2、3 和 4 号外显子。扩增子的测序使用 BigDye Terminator Cycle Sequencing Ready Reaction Kit,按照生产商的规程进行双向测序:结果:根据我们的文献综述,C*07:359 是 HLA-C 位点上一个在全球普通人群中不常见的等位基因。但在本研究中,我们在台湾普通人群中观察到了这一等位基因(频率为 0.41%),尤其是在台湾原住民中,其频率为 0.23%。此外,我们还在两个原住民家庭中推断出两种可能与 C*07:359 相关的 HLA 单倍型:A*24:02-C*07:359-B*39:01-DRB1*04:36 and A*24:02-C*07:359-B*39:01-DRB1*04:04.Conclusion:我们在此报告的与不常见的C*07:359等位基因相关的两种推导出的HLA单倍型对HLA组织配型实验室有参考价值,对干细胞移植捐献者搜索协调员也有价值,他们可以确定在非亲属骨髓捐献者登记册中为携带不常见HLA等位基因的患者找到相合捐献者的可能性。由于C*07:359主要在台湾原住民中发现,我们认为我们在此报告的等位基因及其单倍型在人口和人类学研究中具有重要意义。
{"title":"Association of HLA-C*07:359 with HLA-A, -B, and -DRB1 alleles in Taiwanese.","authors":"Kuo-Liang Yang, Py-Yu Lin","doi":"10.4103/tcmj.tcmj_288_23","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_288_23","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;It is thought that Taiwanese indigenous people were the \"first people\" to populate Taiwan (Formosa) having been there for over 5000 years, preceding the Dutch colonization (from 1624 to 1662) and Spanish colonization (from 1626 to 1642). Taiwan's indigenes, represented by Austronesian language speakers, currently constitute approximately 2% of the total population in Taiwan. It is unknown whether they evolved from Taiwan's Paleolithic or Neolithic cultures, arrived during or after the Neolithic period from China or Southeast Asia or both. HLA studies on the Taiwanese indigenous population have found several intriguing genetic information showing one or two relatively frequently observed alleles and a small number of relatively less frequently observed ones. We report here a relatively frequently observed HLA-C*07:359 allele in the Taiwanese indigenous population, its linkage with HLA-B*39:01, and its probable associated HLA haplotype in two Taiwanese indigenous families. HLA-C*07:359 is a rarely observed allele in the HLA-C locus in the world populations. The objective of this study is to report the allele HLA-C*07:359 that is more frequently found in the Taiwanese population, especially in the Taiwanese indigenous people, to demonstrate that it has a close linkage with HLA-B*39:01 allele in the HLA-B locus and to show the plausible deduced HLA-A-C-B-DRB1-DQB1 haplotypes in association with HLA-C*07:359 in two families of Taiwanese indigenous unrelated individuals.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;The samples were peripheral whole blood, with dipotassium ethylenediaminetetraacetic acid and/or acid citrate dextrose anticoagulation additives. The sequence-based typing method was employed to confirm the low incidence of the allele of HLA-C*07:359 observed in Taiwanese. Polymerase chain reaction was carried out to amplify exons 2, 3, and 4 of the HLA-A,-B,-C,-DRB1 and-DQB1 loci with group-specific primer sets. Amplicons were sequenced using the BigDye Terminator Cycle Sequencing Ready Reaction Kit in both directions according to the manufacturer's protocol.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;C*07:359 is an uncommon allele in the HLA-C locus in the world general population, according to our literature review. However, in this study, it is observed in the general Taiwanese population (frequency 0.41%), especially in the Taiwanese indigenous people at a frequency of 0.23%. In addition, we deduced two probable HLA haplotypes in association with C*07:359 in two indigenous families: A*24:02-C*07:359-B*39:01-DRB1*04:36 and A*24:02-C*07:359-B*39:01-DRB1*04:04.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The two deduced HLA haplotypes associated with the uncommon C*07:359 allele that we report here are valuable for HLA tissue typing laboratories for reference purposes and for stem cell transplantation donor search coordinators to determine the likelihood of finding compatible donors in unrelated bone marrow donor registries fo","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"36 2","pages":"166-174"},"PeriodicalIF":1.5,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11025586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traditional Chinese medicine treatment for benign thyroid nodules: Literature review. 良性甲状腺结节的中医治疗:文献综述。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-26 eCollection Date: 2024-04-01 DOI: 10.4103/tcmj.tcmj_178_23
Chun-Yao Cheng, Ching-Yuan Chen, Jian-Jung Chen, Chia-Ying Chuang

Thyroid nodules (TNs) are pathological changes characterized by abnormal proliferation of thyroid gland tissue. Approximately 19% to 67% of asymptomatic individuals are diagnosed with TNs, with the majority being benign nodules and 4% to 6.5% being thyroid cancer nodules. Western medicine recommends regular examinations and surgery, while traditional Chinese medicine (TCM) provides an alternative choice to maintain thyroid function and reduce the need for surgery. However, in Taiwan, research on TCM treatment for benign TNs is primarily limited to case reports, lacking large-scale and systematic clinical studies. We conducted a search of electronic databases including PubMed, Google Scholar, Wanfang Data, and China National Knowledge Infrastructure to collect clinical trials related to TCM treatment for TNs. Our goal is to provide new treatment options, further validate the value of TCM in the treatment of TNs, and lay a foundation for future clinical research.

甲状腺结节(TNs)是以甲状腺组织异常增生为特征的病理变化。约有19%至67%的无症状者被诊断出患有甲状腺结节,其中大多数为良性结节,4%至6.5%为甲状腺癌结节。西医建议定期检查和手术治疗,而传统中医则为维持甲状腺功能和减少手术需要提供了另一种选择。然而,在台湾,中医治疗良性甲状腺结节的研究主要局限于病例报告,缺乏大规模、系统性的临床研究。我们检索了PubMed、Google Scholar、万方数据和中国国家知识基础设施等电子数据库,收集了与中医药治疗TNs相关的临床试验。我们的目标是提供新的治疗方案,进一步验证中医药在TNs治疗中的价值,并为未来的临床研究奠定基础。
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引用次数: 0
The role of the GABAergic system on insomnia. GABA 能系统在失眠症中的作用。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-26 eCollection Date: 2024-04-01 DOI: 10.4103/tcmj.tcmj_243_23
Peeraporn Varinthra, Shameemun Naseer Mohamed Nizarul Anwar, Shu-Ching Shih, Ingrid Y Liu

Sleep is an essential activity for the survival of mammals. Good sleep quality helps promote the performance of daily functions. In contrast, insufficient sleep reduces the efficiency of daily activities, causes various chronic diseases like Alzheimer's disease, and increases the risk of having accidents. The GABAergic system is the primary inhibitory neurotransmitter system in the central nervous system. It transits the gamma-aminobutyric acid (GABA) neurotransmitter via GABAA and GABAB receptors to counterbalance excitatory neurotransmitters, such as glutamate, noradrenaline, serotonin, acetylcholine, orexin, and dopamine, which release and increase arousal activities during sleep. Several studies emphasized that dysfunction of the GABAergic system is related to insomnia, the most prevalent sleep-related disorder. The GABAergic system comprises the GABA neurotransmitter, GABA receptors, GABA synthesis, and degradation. Many studies have demonstrated that GABA levels correlate with sleep quality, suggesting that modulating the GABAergic system may be a promising therapeutic approach for insomnia. In this article, we highlight the significance of sleep, the classification and pathology of insomnia, and the impact of the GABAergic system changes on sleep. In addition, we also review the medications that target the GABAergic systems for insomnia, including benzodiazepines (BZDs), non-BZDs, barbiturates, GABA supplements, and Chinese herbal medicines.

睡眠是哺乳动物生存的基本活动。良好的睡眠质量有助于促进日常功能的发挥。相反,睡眠不足则会降低日常活动的效率,引发阿尔茨海默病等各种慢性疾病,并增加发生意外的风险。GABA 能系统是中枢神经系统中主要的抑制性神经递质系统。它通过 GABAA 和 GABAB 受体转运γ-氨基丁酸(GABA)神经递质,以平衡谷氨酸、去甲肾上腺素、5-羟色胺、乙酰胆碱、奥曲肽和多巴胺等兴奋性神经递质,这些神经递质在睡眠期间释放并增加唤醒活动。一些研究强调,GABA 能系统的功能障碍与失眠这一最普遍的睡眠相关疾病有关。GABA 能系统包括 GABA 神经递质、GABA 受体、GABA 合成和降解。许多研究表明,GABA 水平与睡眠质量相关,这表明调节 GABA 能系统可能是治疗失眠症的一种有前景的方法。在本文中,我们将重点介绍睡眠的意义、失眠的分类和病理,以及 GABA 能系统变化对睡眠的影响。此外,我们还回顾了针对GABA能系统治疗失眠的药物,包括苯二氮卓类药物(BZD)、非BZD类药物、巴比妥类药物、GABA补充剂和中药。
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引用次数: 0
Exercise under hypoxia on glucose tolerance in type 2 diabetes mellitus risk individuals: A systematic review and meta-analysis. 缺氧条件下的运动对 2 型糖尿病高危人群葡萄糖耐量的影响:系统回顾和荟萃分析。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-26 eCollection Date: 2024-04-01 DOI: 10.4103/tcmj.tcmj_144_23
Hafizah Sururul Nur Rakhmawati, Citrawati Dyah Kencono Wungu, Bambang Purwanto, Andre Andarianto

Objectives: To analyze the impact of exercise under hypoxic exposure versus normoxic exposure on blood glucose level, insulin level, and insulin sensitivity in people at risk of Type 2 diabetes mellitus (T2DM).

Materials and methods: We systematically performed electronic searching on PubMed, Web of Science, ProQuest, and Scopus. Primary studies that met the inclusion criteria were analyzed using Revman 5.4.1.

Results: Nine randomized controlled trials were included in this meta-analysis. We found that physical exercise under hypoxic exposure had no significant effect on improving blood glucose levels, insulin levels, and insulin sensitivity in the elderly and sedentary people compared to normoxic condition. However, physical exercise during hypoxic exposure had a significant effect on lowering blood glucose levels in overweight/obese individuals (pooled Standardized Mean Difference = 0.29; 95% confidence interval = 0.01-0.57; P = 0.04).

Conclusions: Exercising under hypoxic exposure can be an alternative strategy for reducing blood glucose levels in overweight/obese people. Nevertheless, in other populations at risk of T2DM, exercising in hypoxic conditions gives similar results to normoxic conditions.

目的分析低氧暴露与常氧暴露下的运动对 2 型糖尿病(T2DM)高风险人群的血糖水平、胰岛素水平和胰岛素敏感性的影响:我们在 PubMed、Web of Science、ProQuest 和 Scopus 上进行了系统的电子检索。结果:共纳入 9 项随机对照试验:本次荟萃分析共纳入了九项随机对照试验。我们发现,与常氧条件相比,缺氧条件下的体育锻炼对改善老年人和久坐人群的血糖水平、胰岛素水平和胰岛素敏感性没有明显作用。然而,在缺氧条件下进行体育锻炼对降低超重/肥胖者的血糖水平有明显作用(汇总标准化平均差 = 0.29;95% 置信区间 = 0.01-0.57;P = 0.04):结论:在缺氧环境下锻炼是降低超重/肥胖者血糖水平的另一种策略。结论:在低氧条件下锻炼是降低超重/肥胖人群血糖水平的另一种策略。然而,在其他有患 T2DM 风险的人群中,在低氧条件下锻炼的效果与常氧条件下相似。
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引用次数: 0
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Tzu Chi Medical Journal
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