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Mediterranean diet as a modifiable risk factor for age-related macular degeneration: A systematic review and meta-analysis 地中海饮食作为年龄相关性黄斑变性的可改变危险因素:系统回顾和荟萃分析
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-11-07 DOI: 10.4103/tcmj.tcmj_153_23
Maria Angelia, Yufilia Suci Amelia, Kevin Gracia Pratama
A BSTRACT Objectives: Age-related macular degeneration (AMD) is a chronic and degenerative disease of the retina that leads to irreversible blindness. There is no proven effective treatment for early AMD and advanced AMD. Mediterranean diet (MD) has been linked to reducing the risk or delaying the progression of AMD. Therefore, in this study, we aim to investigate the potential of MD as a modifiable risk factor for AMD. Materials and Methods: A systematic search was performed in three databases: PubMed, EBSCO host, and Proquest. We search for studies that determine the association of MD in AMD. Then, we pooled the data for meta-analysis. Results: Eight studies were included in our systematic review. Seven studies were included for meta-analysis. Subjects with medium–high (hazard ratio [HR] 0.82; 95% confidence interval [CI]: 0.75–0.90) adherence to the MD showed a reduced risk of developing AMD. Moreover, medium adherence AMD shows a significant and inverse relationship with the progression to advanced AMD (HR: 0.87; 95% CI: 0.81–0.93). Although it is still inconsistent, the reduction appears stronger for geographic atrophy than for neovascular AMD. Conclusion: Adhering to the MD, particularly at a medium to high level, appears to confer a protective effect against AMD. The sub-analysis demonstrates even that there is a protective effect associated with moderate adherence against advanced AMD. The presence of considerable heterogeneity within the results warrants cautious interpretation. Further research is needed to enhance our understanding.
摘要目的:年龄相关性黄斑变性(AMD)是一种慢性视网膜退行性疾病,可导致不可逆的失明。对于早期和晚期黄斑变性没有有效的治疗方法。地中海饮食(MD)与降低AMD的风险或延缓AMD的进展有关。因此,在本研究中,我们的目的是研究MD作为AMD的可改变危险因素的潜力。材料和方法:在PubMed、EBSCO主机和Proquest三个数据库中进行系统检索。我们寻找确定AMD中MD关联的研究。然后,我们汇总数据进行meta分析。结果:我们的系统综述纳入了8项研究。纳入7项研究进行荟萃分析。中高(风险比[HR] 0.82;95%可信区间[CI]: 0.75-0.90),坚持MD的患者患AMD的风险降低。此外,中等依从性AMD与进展为晚期AMD呈显著负相关(HR: 0.87;95% ci: 0.81-0.93)。尽管仍不一致,但地理性萎缩的减少似乎比新生血管性AMD更强。结论:坚持MD,特别是中高水平的MD,似乎对AMD具有保护作用。亚分析甚至表明,中度依从性对晚期AMD有保护作用。结果中存在相当大的异质性,值得谨慎解释。需要进一步的研究来增强我们的认识。
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引用次数: 0
Detecting circulating microbial cell-free DNA by next-generation sequencing in patients with Mycobacterium avium complex-lung disease: A pilot study 新一代测序检测鸟分枝杆菌复合肺部疾病患者循环微生物无细胞DNA:一项初步研究
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-11-07 DOI: 10.4103/tcmj.tcmj_191_23
Yen-Han Tseng, Sheng-Wei Pan, Jia-Yih Feng, Wei-Juin Su, Chi-Ying F Huang, Yuh-Min Chen
A BSTRACT Objectives: Determining a diagnosis for non- Tuberculous mycobacterium (NTM)-lung disease (LD) remains difficult. The value of circulating cell-free DNA (cfDNA) secreted from microbes has been established in the detection of pathogens in septic patients. However, it is unknown whether NTM-derived cfDNA is detectable in plasma from patients with NTM-LD and whether this is associated with the disease status of NTM-LD, especially in patients with Mycobacterium avium complex (MAC)-LD. Materials and Methods: In this pilot study, from 2018 to 2019, we enrolled adult patients with MAC-LD at Taipei Veterans General Hospital in Taiwan for the detection of circulating cfDNA. We performed cfDNA extraction from plasma, next-generation sequencing (NGS) for nonhuman cfDNA, and sequence matching to a microbial database and then assessed the association between pathogen cfDNA and MAC-LD. Results: Two (40%) plasma samples from MAC-LD patients had detectable MAC-specific cfDNA, namely one instance of DNA polymerase III alpha subunit and one instance of ATP-binding cassette transporters permease. The plasma samples from the three other MAC-LD cases and the one tuberculosis control were negative for either NTM-derived cfDNA or tuberculosis-related cfDNA. In addition to MAC-specific cfDNA, Ralstonia solanacearum , Staphylococcus aureus , and Pasteurella multocida were the most observed bacteria in our patients. The two patients with MAC-cfDNA positivity yielded higher radiographic scores ( P = 0.076) and presented a higher number of nonhuman reads than those without MAC-cfDNA positivity ( P = 0.083). Conclusion: Using NGS method, we demonstrated MAC-cfDNA was detectable in patients with MAC-LD. Further large-scale research is warranted to assess the clinical value of detecting MAC-specific cfDNA in MAC-LD patients.
目的:确定非结核分枝杆菌(NTM)肺部疾病(LD)的诊断仍然很困难。微生物分泌的循环游离DNA (cfDNA)在脓毒症患者病原体检测中的价值已经确立。然而,目前尚不清楚ntm衍生的cfDNA是否可在NTM-LD患者的血浆中检测到,以及这是否与NTM-LD的疾病状态有关,特别是在鸟分枝杆菌复合物(MAC)-LD患者中。材料与方法:在2018年至2019年的这项试点研究中,我们招募了台湾台北退伍军人总医院的成年MAC-LD患者检测循环cfDNA。我们从血浆中提取cfDNA,对非人类cfDNA进行下一代测序(NGS),并与微生物数据库进行序列匹配,然后评估病原体cfDNA与MAC-LD之间的关系。结果:来自MAC-LD患者的两个(40%)血浆样本检测到mac特异性cfDNA,即一个DNA聚合酶III α亚基和一个atp结合盒转运体渗透酶。另外3例MAC-LD病例和1例结核对照的血浆样本对ntm衍生cfDNA或结核相关cfDNA均为阴性。除mac特异性cfDNA外,在我们的患者中观察到最多的细菌是葡萄球菌、金黄色葡萄球菌和多杀性巴氏杆菌。两例MAC-cfDNA阳性患者的放射学评分较高(P = 0.076),非人类reads数量高于未呈MAC-cfDNA阳性的患者(P = 0.083)。结论:采用NGS方法,我们证实MAC-cfDNA可在MAC-LD患者中检测到。需要进一步的大规模研究来评估在MAC-LD患者中检测mac特异性cfDNA的临床价值。
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引用次数: 0
Effectiveness of Vitamin D supplementation in combination with calcium on risk of maternal and neonatal outcomes: A quasi-experimental clinical trial 维生素D与钙联合补充对孕产妇和新生儿结局风险的有效性:一项准实验性临床试验
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-31 DOI: 10.4103/tcmj.tcmj_184_23
Deldar Morad Abdulah, Jinan Nori Hasan, Sheelan Bapir Hasan
Abstract Objectives: We examined the effectiveness of combining Vitamin D supplementation with calcium on maternal and neonatal outcomes, as opposed to using Vitamin D supplements alone. Materials and Methods: Pregnant women in their third trimester were divided into two groups. The control group received a daily dose of 1000 IU of Vitamin D, but, the experimental group received a combined daily dosage of 1000 IU of Vitamin D and 500 mg of calcium, until delivery. Results: The women in the Vitamin D + calcium group were less likely to develop gestational diabetes (2.78%; vs. 19.51%; P = 0.0318), preeclampsia (2.78% vs. 26.83%; P = 0.004), newly onset gestational hypertension (11.11% vs. 46.34%; P = 0.001), proteinuria (5.56% vs. 39.02%; P = 0.0004), and impaired glucose tolerance (2.78% vs. 21.95%; P = 0.0163) and had lower blood pressure at 20 th and 39 th weeks of gestation. The newborns in the Vitamin D + calcium group were less likely to experience low birth weight (5.71% vs. 31.58%; P = 0.0066), low birth length (5.71% vs. 44.74%; P = 0.0007), were less likely to be admitted to the neonatal intensive care unit (14.29% vs. 42.11%; P = 0.0105), have a larger head circumference (35.00 vs. 33.63; P < 0.0001), longer gestational age at birth (40.0 vs. 37.56 weeks; P < 0.0001), and higher APGAR scores (9.58 vs. 6.31; P < 0.0001.) compared to Vitamin D group, respectively. Conclusions: Taking Vitamin D and calcium by pregnant women in the third trimester is an effective treatment to decrease maternal, fetal, and neonatal outcomes.
目的:我们研究了维生素D与钙联合补充对孕产妇和新生儿结局的影响,而不是单独使用维生素D补充剂。材料与方法:将妊娠晚期孕妇分为两组。对照组每天服用1000国际单位的维生素D,而实验组每天服用1000国际单位的维生素D和500毫克的钙,直到分娩。结果:维生素D +钙组妇女发生妊娠糖尿病的可能性较低(2.78%;比19.51%;P = 0.0318),子痫前期(2.78% vs. 26.83%;P = 0.004),新发妊娠期高血压(11.11% vs. 46.34%;P = 0.001)、蛋白尿(5.56% vs. 39.02%;P = 0.0004),葡萄糖耐量受损(2.78% vs. 21.95%;P = 0.0163),妊娠第20周和第39周血压较低。维生素D +钙组新生儿低出生体重的可能性较小(5.71% vs. 31.58%;P = 0.0066),低出生长度(5.71% vs. 44.74%;P = 0.0007),进入新生儿重症监护病房的可能性较低(14.29% vs. 42.11%;P = 0.0105),头围较大(35.00 vs. 33.63;P & lt;0.0001),出生时胎龄较长(40.0 vs. 37.56周;P & lt;0.0001),以及更高的APGAR评分(9.58 vs. 6.31;P & lt;0.0001.),与维生素D组相比。结论:孕妇在妊娠晚期服用维生素D和钙是降低母体、胎儿和新生儿结局的有效治疗方法。
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引用次数: 0
Folic acid: The key to a healthy pregnancy – A prospective study on fetomaternal outcome 叶酸:健康妊娠的关键——一项对胎儿结局的前瞻性研究
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-31 DOI: 10.4103/tcmj.tcmj_110_23
Madhusudan Dey, Pranjali Dhume, Sanjay K Sharma, Suyash Goel, Sunil Chawla, Ankur Shah, G Madhumidha, Reshu Rawal
A BSTRACT Objective: The objective of the study is to study the fetomaternal outcome associated with folic acid deficiency in pregnancy. Materials and Methods: This hospital-based observational study was conducted in the Department of Obstetrics and Gynaecology at Base Hospital, Delhi Cantt, and a total of 351 participants were enrolled who were fulfilling the inclusion criteria. The plasma folic acid level of the selected patients was measured in the booking visit by automated chemiluminescence assay. The cutoff levels of folic acid were taken at 8.6 ng/mL. Based on these values, the study population was divided into two groups, one with folic acid values <8.6 ng/mL and the other with values ≥8.6 ng/mL. Plasma Vitamin B12 levels were measured to check for any concurrent deficiencies. Obstetric outcomes included first- and second-trimester miscarriages, development of anemia, gestational hypertension/preeclampsia, gestational diabetes mellitus, hypothyroidism, placental abruption, and intrauterine fetal growth restriction (FGR). Furthermore, the period of gestation at delivery, fetal weights, APGAR scores at 5 min were documented. The study also considered fetal neural tube defects, intrauterine fetal demise for data collection. Collected data were analyzed statistically to find the association of the above-mentioned outcomes with levels of folic acid. Results: The rate of preterm deliveries was significantly higher in the folic acid group with levels <8.6 ng/mL (16.94%). The incidence of small for gestational age/FGR was higher in the folic acid group with levels <8.6 ng/mL (27.11%) compared to the high folic acid group with levels ≥8.6 ng/mL (13.38%). The differences in the incidence of anemia, gestational hypertension, gestational diabetes, and preeclampsia between the two groups were not statistically significant and no cases of intrauterine fetal demise or placental abruption were observed in either group. Moreover, there was no significant difference in the relative risk of low Apgar scores at 5 min between the two groups. Conclusion: The present study suggests that low folic acid levels during pregnancy are associated with a higher risk of adverse pregnancy outcomes such as anemia, miscarriages, preterm delivery, and FGR. Therefore, adherence to nutritional recommendation of folic acid supplementation during pregnancy is essential to prevent these adverse outcomes.
摘要目的:本研究的目的是研究妊娠期叶酸缺乏对胎儿结局的影响。材料和方法:这项以医院为基础的观察性研究在德里坎特基地医院的妇产科进行,总共招募了351名符合纳入标准的参与者。所选患者的血浆叶酸水平在预约就诊时采用自动化学发光法测定。叶酸的临界值为8.6 ng/mL。根据这些数值,将研究人群分为两组,一组叶酸值为8.6 ng/mL,另一组叶酸值≥8.6 ng/mL。测量血浆维生素B12水平,以检查是否同时缺乏维生素B12。产科结局包括妊娠早期和中期流产、贫血、妊娠高血压/先兆子痫、妊娠糖尿病、甲状腺功能减退、胎盘早剥和宫内胎儿生长受限(FGR)。此外,记录分娩时的妊娠期、胎儿体重、5分钟时的APGAR评分。本研究还考虑了胎儿神经管缺陷、宫内胎儿死亡等进行数据收集。对收集到的数据进行统计分析,发现上述结果与叶酸水平有关。结果:叶酸组早产率显著高于对照组(8.6 ng/mL)(16.94%)。叶酸≥8.6 ng/mL组的小胎龄/FGR发生率(27.11%)高于高叶酸≥8.6 ng/mL组(13.38%)。两组间贫血、妊娠高血压、妊娠糖尿病、先兆子痫发生率差异无统计学意义,两组均未发生宫内死胎、胎盘早剥。此外,两组在5分钟低Apgar评分的相对风险方面没有显著差异。结论:目前的研究表明,怀孕期间叶酸水平低与贫血、流产、早产和FGR等不良妊娠结局的高风险相关。因此,在怀孕期间坚持补充叶酸的营养建议对于预防这些不良后果是必不可少的。
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引用次数: 0
Ellagic acid ameliorates renal fibrogenesis by blocking epithelial-to-mesenchymal transition 鞣花酸通过阻断上皮细胞到间质细胞的转变来改善肾纤维化
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-24 DOI: 10.4103/tcmj.tcmj_106_23
Po-Yu Huang, Yi-Hsien Hsieh, Yi-Hsuan Ting, Chu-Che Lee, Jen-Pi Tsai
A BSTRACT Objective: Ellagic acid (EA), a kind of polyphenol found in numerous fruits and vegetables, has anti-inflammatory, anti-apoptotic, anti-oxidant, and anti-fibrotic effects against a variety of diseases, but its role in mediating renal fibrogenesis remains unknown. Materials and Methods: We used an in vivo mouse unilateral ureteral obstruction (UUO) model and an in vitro model with HK-2 cell lines treated with EA and transforming growth factor β1 (TGF-β1). The expression of epithelial-to-mesenchymal transition (EMT)-related proteins of UUO mice was examined using immunohistochemical staining. Liver function and renal function were evaluated using biochemical testing. Western blot analysis was used to determine the proteins related to EMT, and MTT assay was used to determine cell viability. Results: In UUO mice fed EA, both microscopical examination with immunohistochemical staining and western blotting protein analysis showed reduced expression of fibrotic (α-SMA, fibronectin, and collagen I)- and EMT (vimentin and N-cadherin)-related proteins, compared with sham control. In HK-2 cells treated with TGF-β1, EA decreased motility as well as expression of α-SMA, collagen-I, fibronectin, N-cadherin, and vimentin. Conclusion: EA reduced the progression of the morphological transformations and concomitantly suppressed the expression of fibrotic- and EMT-related proteins in vitro and in vivo. These findings improved our understanding of the role of EA in suppressing renal fibrogenesis and demonstrated the promising role EA may play in the management of chronic kidney disease.
摘要目的:鞣花酸(eragic acid, EA)是一种多酚,存在于多种水果和蔬菜中,对多种疾病具有抗炎、抗凋亡、抗氧化和抗纤维化作用,但其在肾脏纤维化中的作用尚不清楚。材料和方法:采用小鼠单侧输尿管梗阻(UUO)体内模型和经EA和转化生长因子β1 (TGF-β1)处理的HK-2细胞系体外模型。免疫组化染色检测UUO小鼠上皮间质转化(EMT)相关蛋白的表达。采用生化试验评价肝功能和肾功能。Western blot法检测EMT相关蛋白,MTT法检测细胞活力。结果:UUO小鼠灌胃EA后,显微镜下免疫组化染色和western blotting蛋白分析均显示,与假对照组相比,纤维化(α-SMA、纤维连接蛋白和I型胶原)和EMT (vimentin和N-cadherin)相关蛋白的表达降低。在TGF-β1处理的HK-2细胞中,EA降低了运动性以及α-SMA、胶原- i、纤维连接蛋白、N-cadherin和vimentin的表达。结论:在体外和体内实验中,EA均能减缓细胞形态转化的进程,同时抑制纤维化蛋白和emt相关蛋白的表达。这些发现提高了我们对EA在抑制肾纤维化中的作用的理解,并证明了EA在慢性肾脏疾病的治疗中可能发挥的有希望的作用。
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引用次数: 0
The beneficial effects of conservative treatment with biofeedback and electrostimulation on pelvic floor disorders 生物反馈和电刺激保守治疗盆底疾病的有益效果
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-22 DOI: 10.4103/tcmj.tcmj_174_23
Mei-Chen Chen, Pei-Hsuan Lai, Dah-Ching Ding
A BSTRACT Objectives: Pelvic floor disorders (PFDs) such as stress urinary incontinence (SUI) and pelvic organ prolapse (POP) can be managed through conservative treatments, such as conservative management involving biofeedback (BF) and electrostimulation. This study aimed to investigate the therapeutic effects of conservative treatments on PFDs. Materials and Methods: A retrospective cohort study was conducted. Women with PFD who underwent 1–3 months of BF and electrostimulation between January 1, 2020, and January 31, 2021, were included in the study. BF treatment was administered using three sensors to monitor pelvic floor muscle activity, providing patients with immediate feedback and guidance on muscle exercises. One session lasted for 5–10 min. Electrostimulation treatment utilized a specially made pelvic belt with electrode sheets to stimulate and contract pelvic floor muscles passively. One session lasted for 15 min. Six therapies in 1 month were prescribed. Pre- and post-treatment Pelvic Floor Distress Inventory (PFDI-20) scores, including POP distress inventory 6 (POPDI-6), colorectal-anal distress inventory (CRAD-8), and urinary distress inventory 6 (UDI-6) scores, were compared. Subgroup analysis by age, menopause, body mass index (BMI), and child delivery mode was performed. Results: The study included 51 women with PFDs (SUI, POP, frequency or urgency or nocturia, and pain) treated with BF and electrostimulation, with a mean age of 49.94 ± 13.63 years. Sixteen patients (37.1%) were menopausal, with a mean menopause age of 50 ± 5.20 years. Twenty-six patients (68.4%) had a history of normal vaginal delivery. The mean PFDI-20 scores before and after treatment were 32.67 (standard deviation [SD] 10.05) and 25.99 (SD 9.61), respectively ( P < 0.001). This decrease in scores reflected an improvement in subjective perceptions of symptoms and quality of life. The POPDI-6, CRAD-8, and UDI-6 scores significantly decreased after treatment. Subgroup analysis of scores change regarding age, menopause, BMI, and child delivery mode was not statistically significant. Conclusions: The study demonstrated the effectiveness of BF and electrostimulation for treating women with PFDs. The findings contributed to the understanding of treatment duration, patient characteristics, and the potential benefits of a multimodal approach. Moreover, the study’s diverse participant population and the use of validated outcome measures enhance the generalizability and scientific rigor of the findings.
目的:盆底疾病(PFDs)如压力性尿失禁(SUI)和盆腔器官脱垂(POP)可以通过保守治疗来治疗,如生物反馈(BF)和电刺激等保守治疗。本研究旨在探讨保守治疗PFDs的疗效。材料和方法:进行回顾性队列研究。在2020年1月1日至2021年1月31日期间接受了1 - 3个月BF和电刺激的PFD女性被纳入研究。BF治疗采用三个传感器监测骨盆底肌肉活动,为患者提供肌肉锻炼的即时反馈和指导。一个疗程持续5-10分钟。电刺激治疗使用特制的带电极片的骨盆带被动刺激和收缩骨盆底肌肉。每次治疗15分钟,1个月内进行6次治疗。比较治疗前后盆底窘迫量表(PFDI-20)评分,包括POP窘迫量表6 (POPDI-6)、结直肠-肛门窘迫量表(CRAD-8)和尿窘迫量表6 (UDI-6)评分。按年龄、绝经期、体重指数(BMI)和分娩方式进行亚组分析。结果:本研究纳入了51例经BF和电刺激治疗的PFDs (SUI、POP、尿频或尿急或夜尿、疼痛)患者,平均年龄49.94±13.63岁。绝经16例(37.1%),平均绝经年龄50±5.20岁。26例(68.4%)有正常阴道分娩史。治疗前后PFDI-20平均评分分别为32.67分(标准差[SD] 10.05)和25.99分(SD 9.61) (P <0.001)。这种分数的下降反映了对症状和生活质量的主观认知的改善。治疗后POPDI-6、CRAD-8、UDI-6评分均显著降低。亚组分析中年龄、绝经期、BMI和分娩方式的评分变化无统计学意义。结论:该研究证明了BF和电刺激治疗女性PFDs的有效性。研究结果有助于了解治疗时间、患者特征和多模式方法的潜在益处。此外,该研究的多样化的参与者群体和有效的结果测量方法的使用增强了研究结果的普遍性和科学严谨性。
{"title":"The beneficial effects of conservative treatment with biofeedback and electrostimulation on pelvic floor disorders","authors":"Mei-Chen Chen, Pei-Hsuan Lai, Dah-Ching Ding","doi":"10.4103/tcmj.tcmj_174_23","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_174_23","url":null,"abstract":"A BSTRACT Objectives: Pelvic floor disorders (PFDs) such as stress urinary incontinence (SUI) and pelvic organ prolapse (POP) can be managed through conservative treatments, such as conservative management involving biofeedback (BF) and electrostimulation. This study aimed to investigate the therapeutic effects of conservative treatments on PFDs. Materials and Methods: A retrospective cohort study was conducted. Women with PFD who underwent 1–3 months of BF and electrostimulation between January 1, 2020, and January 31, 2021, were included in the study. BF treatment was administered using three sensors to monitor pelvic floor muscle activity, providing patients with immediate feedback and guidance on muscle exercises. One session lasted for 5–10 min. Electrostimulation treatment utilized a specially made pelvic belt with electrode sheets to stimulate and contract pelvic floor muscles passively. One session lasted for 15 min. Six therapies in 1 month were prescribed. Pre- and post-treatment Pelvic Floor Distress Inventory (PFDI-20) scores, including POP distress inventory 6 (POPDI-6), colorectal-anal distress inventory (CRAD-8), and urinary distress inventory 6 (UDI-6) scores, were compared. Subgroup analysis by age, menopause, body mass index (BMI), and child delivery mode was performed. Results: The study included 51 women with PFDs (SUI, POP, frequency or urgency or nocturia, and pain) treated with BF and electrostimulation, with a mean age of 49.94 ± 13.63 years. Sixteen patients (37.1%) were menopausal, with a mean menopause age of 50 ± 5.20 years. Twenty-six patients (68.4%) had a history of normal vaginal delivery. The mean PFDI-20 scores before and after treatment were 32.67 (standard deviation [SD] 10.05) and 25.99 (SD 9.61), respectively ( P < 0.001). This decrease in scores reflected an improvement in subjective perceptions of symptoms and quality of life. The POPDI-6, CRAD-8, and UDI-6 scores significantly decreased after treatment. Subgroup analysis of scores change regarding age, menopause, BMI, and child delivery mode was not statistically significant. Conclusions: The study demonstrated the effectiveness of BF and electrostimulation for treating women with PFDs. The findings contributed to the understanding of treatment duration, patient characteristics, and the potential benefits of a multimodal approach. Moreover, the study’s diverse participant population and the use of validated outcome measures enhance the generalizability and scientific rigor of the findings.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136099809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reliability and validity of the Taiwanese version of the collaborative practice assessment tool: A pilot study. 台湾版合作实践评估工具的信度与效度:初步研究。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-07-01 DOI: 10.4103/tcmj.tcmj_200_22
Chen-Pei Ho, Hsiu-Chen Yeh, Ming-Shinn Lee, Wei-Chun Cheng

Objectives: To promote teamwork communication and collaboration between health-care professionals, educators emphasized proper training programs to develop interprofessional collaborative practice (IPCP) among postgraduate (PG) trainees. A literature review indicated that the faculty necessarily measured the competency in IPCP with structured and applicable assessment tools in collocation to training programs domestically. A cross-sectional psychometric study was conducted to construct a reliable assessment tool for measuring PG learning outcome in Taiwan through a bidirectional translation. The study aimed to assess the interprofessional team behavior of trainees using the Taiwanese version of the collaborative practice assessment tool (T-CPAT).

Materials and methods: The study recruited 43 participants to undergo a PG training program in a single institute and to complete T-CPAT. Data were analyzed using SPSS 22.0 software. We employed descriptive analysis of demographic variables. The validity of T-CPAT was analyzed by experts in different specialties and its availability was assessed by item-level analysis. Furthermore, the T-CPAT reliability was tested using Cronbach's α.

Results: The average score was 305.2 (standard deviation = 38.08), and the expert validity of the T-CPAT was 0.96. In the item-level analysis, there were no failure items in T-CAPT. Cronbach's α reached 0.94 (95% confidence interval = 0.90-0.96).

Conclusion: The study demonstrated good reliability and validity for the T-CPAT. Thus, the T-CPAT can be used to accurately measure and assess the competence of IPCP in PG trainees in general medicine in Taiwan. The results were deemed sufficient to provide faculties with related arrangements for future teaching plans.

目的:为了促进卫生保健专业人员之间的团队沟通和协作,教育工作者强调了适当的培训计划,以培养研究生(PG)学员的跨专业协作实践(IPCP)。文献综述表明,在国内的培训项目中,教师必须使用结构化和适用的评估工具来衡量IPCP的能力。本研究以横断面心理测量学为研究对象,透过双向翻译,建构一个可靠的评估工具来测量台湾地区PG学习效果。本研究旨在运用台湾版合作实践评估工具(T-CPAT)评估实习生的跨专业团队行为。材料和方法:本研究招募了43名参与者在一个机构接受PG培训计划并完成T-CPAT。数据分析采用SPSS 22.0软件。我们采用人口统计变量的描述性分析。采用不同专业的专家分析T-CPAT的效度,采用项目水平分析评估其有效性。采用Cronbach’s α检验T-CPAT信度。结果:T-CPAT的平均得分为305.2分(标准差为38.08),专家效度为0.96。在项目层面分析中,T-CAPT不存在不合格项目。Cronbach’s α达到0.94(95%置信区间= 0.90-0.96)。结论:T-CPAT具有良好的信度和效度。因此,T-CPAT可以准确地衡量和评估台湾全科医学PG学员的IPCP能力。研究结果足以为院系未来的教学计划作出相关安排。
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引用次数: 0
The effects of rehabilitation on functional independence of Eastern Taiwanese children with rare or genetic diseases. 康复对台湾东部罕见或遗传疾病儿童功能独立的影响。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-07-01 DOI: 10.4103/tcmj.tcmj_170_22
Yu-Chuan Lin, Chun-Ying Weng, Chung-Chao Liang, Shao-Yin Chu

Objectives: This study investigated the effects of outpatient rehabilitation therapy (RT) on the functional performance of children from Eastern Taiwan with rare or genetic diseases.

Materials and methods: This retrospective observational cohort study included 73 children from Eastern Taiwan who were affected with rare or genetic diseases, with an average age of 8.57 ± 5.33 years (47 boys and 26 girls). Each child received the goal-directed therapy known as outpatient RT, which was delivered by a multidisciplinary team of specialists. To assess the effectiveness of RT, the WeeFIM-C questionnaire data were collected and analyzed.

Results: After receiving outpatient RT, most of the children only required low-to-moderate assistance with self-care tasks (4.36 ± 2.38), and they could perform mobility-related activities under supervision or independently (5.70 ± 2.29). Moreover, most only required minimal assistance with tasks related to cognitive functioning and tended to complete such tasks under supervision (4.97 ± 2.05). The functional performance was significantly different among three studied groups, in terms of self-care (F[2, 68] = 5.42, P < 0.007), mobility (F[2, 68] = 8.17, P < 0.001), cognitive functioning (F[2, 68] = 3.31, P < 0.042), and overall (F[2, 68] = 6.44, P < 0.003) functional performance.

Conclusion: The results of this study demonstrated that the functional status was different among three studied groups in terms of self-care, mobility, and cognitive functioning after receiving outpatient RT.

摘要目的:探讨门诊康复治疗对台湾东部罕见或遗传性疾病患儿功能表现的影响。材料与方法:本研究采用回顾性观察队列研究,纳入台湾东部罕见或遗传性疾病患儿73例,平均年龄8.57±5.33岁(男童47例,女童26例)。每个孩子都接受了目标导向的治疗,称为门诊RT,由多学科专家团队提供。为了评估RT的有效性,收集并分析WeeFIM-C问卷数据。结果:接受门诊RT治疗后,大多数患儿仅需要低至中等程度的自我照顾协助(4.36±2.38),可在监护下或独立进行活动相关活动(5.70±2.29)。此外,大多数人在完成与认知功能相关的任务时只需要很少的帮助,并倾向于在监督下完成这些任务(4.97±2.05)。三组患者在自我护理(F[2,68] = 5.42, P < 0.007)、活动能力(F[2,68] = 8.17, P < 0.001)、认知功能(F[2,68] = 3.31, P < 0.042)、整体功能表现(F[2,68] = 6.44, P < 0.003)方面存在显著差异。结论:本研究结果表明,三组患者在接受门诊RT治疗后,在自我护理、活动能力和认知功能方面的功能状态存在差异。
{"title":"The effects of rehabilitation on functional independence of Eastern Taiwanese children with rare or genetic diseases.","authors":"Yu-Chuan Lin,&nbsp;Chun-Ying Weng,&nbsp;Chung-Chao Liang,&nbsp;Shao-Yin Chu","doi":"10.4103/tcmj.tcmj_170_22","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_170_22","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the effects of outpatient rehabilitation therapy (RT) on the functional performance of children from Eastern Taiwan with rare or genetic diseases.</p><p><strong>Materials and methods: </strong>This retrospective observational cohort study included 73 children from Eastern Taiwan who were affected with rare or genetic diseases, with an average age of 8.57 ± 5.33 years (47 boys and 26 girls). Each child received the goal-directed therapy known as outpatient RT, which was delivered by a multidisciplinary team of specialists. To assess the effectiveness of RT, the WeeFIM-C questionnaire data were collected and analyzed.</p><p><strong>Results: </strong>After receiving outpatient RT, most of the children only required low-to-moderate assistance with self-care tasks (4.36 ± 2.38), and they could perform mobility-related activities under supervision or independently (5.70 ± 2.29). Moreover, most only required minimal assistance with tasks related to cognitive functioning and tended to complete such tasks under supervision (4.97 ± 2.05). The functional performance was significantly different among three studied groups, in terms of self-care (<i>F</i><sub>[2, 68]</sub> = 5.42, <i>P</i> < 0.007), mobility (<i>F</i><sub>[2, 68]</sub> = 8.17, <i>P</i> < 0.001), cognitive functioning (<i>F</i><sub>[2, 68]</sub> = 3.31, <i>P</i> < 0.042), and overall (<i>F</i><sub>[2, 68]</sub> = 6.44, <i>P</i> < 0.003) functional performance.</p><p><strong>Conclusion: </strong>The results of this study demonstrated that the functional status was different among three studied groups in terms of self-care, mobility, and cognitive functioning after receiving outpatient RT.</p>","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"35 3","pages":"221-225"},"PeriodicalIF":1.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/76/TCMJ-35-221.PMC10399839.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9943340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finite element analysis to assess stress and deformation in bone with glass fiber-reinforced-poly-ether-ether-ketone, zirconia, and titanium implants. 用有限元分析评估玻璃纤维增强聚醚醚酮、氧化锆和钛植入物在骨中的应力和变形。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-07-01 DOI: 10.4103/tcmj.tcmj_184_22
Syeda Amtul Haseeb, Anju S Kumar, M P Chaitra, K C Vinaya, Soumya Shivananda Gudal, Fathima Parveen Rahmam, Prashant Babaji

Objectives: Recently, zirconia ceramic and glass or carbon fiber-reinforced poly-ether-ether-ketone (PEEK) composites have been introduced as newer implant biomaterials. This study was done to evaluate stress and deformation in bone with glass fiber-reinforced (GFR)-PEEK, zirconia, and titanium implants.

Materials and methods: A geometric model of mandibular molar replaced with implant-supported crown was generated. Implant of 12 mm length and 4.5 mm diameter was used in study. Finite element analysis models of implant assemblies of three materials GFR-PEEK, zirconium, and titanium were generated. 150 N loads were applied obliquely and vertically along the long axis of implant. Von Mises stresses and deformation generated were compared using ANSYS Workbench 17.0 and finite element software.

Results: All three implant assemblies, i.e., GFR-PEEK, zirconia, and titanium, demonstrated similar stresses and deformation in bone without significant difference.

Conclusion: It was concluded that GFR-PEEK and zirconia implants can be used as a substitute to titanium implants.

目的:近年来,氧化锆陶瓷和玻璃或碳纤维增强聚醚醚酮(PEEK)复合材料作为较新的植入生物材料被引入。本研究评估了玻璃纤维增强(GFR)-PEEK、氧化锆和钛植入物对骨的应力和变形。材料与方法:制作种植冠代替下颌磨牙的几何模型。种植体长度为12mm,直径为4.5 mm。建立了GFR-PEEK、锆、钛三种材料种植体组件的有限元分析模型。沿种植体长轴斜向和垂直方向施加150 N载荷。利用ANSYS Workbench 17.0和有限元软件对产生的Von Mises应力和变形进行比较。结果:GFR-PEEK、氧化锆和钛三种种植体组件在骨内的应力和变形相似,无显著差异。结论:GFR-PEEK和氧化锆种植体可作为钛种植体的替代材料。
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引用次数: 1
Pathophysiology, clinical presentation, and management of ketamine-induced cystitis. 氯胺酮性膀胱炎的病理生理、临床表现和治疗。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-07-01 DOI: 10.4103/tcmj.tcmj_94_23
Jia-Fong Jhang, Lori A Birder, Hann-Chorng Kuo

Ketamine is illegally used as a recreational drug in many Asian countries. Long-term ketamine abusers often develop irritable bladder symptoms that gradually develop into more severe urinary frequency and urgency and eventually into a painful ulcerated bladder. These patients typically have reduced functional bladder capacity, increased bladder sensation, detrusor overactivity, severe urgency, urinary incontinence, and bladder contracture. Ketamine metabolites can cause severe inflammation of the urothelium, urothelial barrier deficits, vascular endothelial fibrinoid changes, increased oxidative stress, and bladder wall fibrosis. A decrease in bladder compliance, urinary tract infection, severe bladder pain with a full bladder, and painful micturition are also common symptoms. Finally, with continued abuse of ketamine, hydronephrosis, ureteral stricture, vesicoureteral reflux, and renal failure may develop. Cessation of ketamine is the mainstay of treatment. Lower urinary tract symptoms usually relapse if patients reuse ketamine after stopping. In cases of severe ketamine cystitis, only augmentation enterocystoplasty can relieve bladder pain and restore normal lower urinary tract function. This article reviews the underlying pathophysiology, clinical characteristics, and management of ketamine cystitis.

氯胺酮在许多亚洲国家被非法用作消遣性毒品。长期氯胺酮滥用者经常出现膀胱易激症状,逐渐发展为更严重的尿频和尿急,最终导致膀胱溃疡。这些患者通常有膀胱功能减少、膀胱感觉增加、逼尿肌过度活动、严重尿急、尿失禁和膀胱挛缩。氯胺酮代谢物可引起严重的尿路上皮炎症、尿路上皮屏障缺陷、血管内皮纤维蛋白样改变、氧化应激增加和膀胱壁纤维化。膀胱顺应性下降、尿路感染、膀胱充血时严重的膀胱疼痛和排尿疼痛也是常见的症状。最后,随着氯胺酮的持续滥用,可能会发生肾积水、输尿管狭窄、膀胱输尿管反流和肾功能衰竭。停用氯胺酮是治疗的主要手段。如果患者停用氯胺酮后再次使用,下尿路症状通常会复发。对于严重氯胺酮性膀胱炎的病例,只有增强肠囊成形术才能缓解膀胱疼痛,恢复正常的下尿路功能。本文综述了氯胺酮性膀胱炎的病理生理、临床特点和治疗。
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引用次数: 0
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Tzu Chi Medical Journal
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