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Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification. 第五次中枢神经系统世界卫生组织分类中的儿童型弥漫性高级别胶质瘤。
IF 4.4 Q1 PATHOLOGY Pub Date : 2022-12-01 DOI: 10.32074/1591-951X-830
Francesca Gianno, Isabella Giovannoni, Barbara Cafferata, Francesca Diomedi-Camassei, Simone Minasi, Sabina Barresi, Francesca Romana Buttarelli, Viola Alesi, Antonello Cardoni, Manila Antonelli, Chiara Puggioni, Giovanna Stefania Colafati, Andrea Carai, Maria Vinci, Angela Mastronuzzi, Evelina Miele, Rita Alaggio, Felice Giangaspero, Sabrina Rossi

As a relevant element of novelty, the fifth CNS WHO Classification highlights the distinctive pathobiology underlying gliomas arising primarily in children by recognizing for the first time the families of paediatric-type diffuse gliomas, both high-grade and low-grade. This review will focus on the family of paediatric-type diffuse high-grade gliomas, which includes four tumour types: 1) Diffuse midline glioma H3 K27-altered; 2) Diffuse hemispheric glioma H3 G34-mutant; 3) Diffuse paediatric-type high-grade glioma H3-wildtype and IDH-wildtype; and 4) Infant-type hemispheric glioma. The essential and desirable diagnostic criteria as well as the entities entering in the differential will be discussed for each tumour type. A special focus will be given on the issues encountered in the daily practice, especially regarding the diagnosis of the diffuse paediatric-type high-grade glioma H3-wildtype and IDH-wildtype. The advantages and the limits of the multiple molecular tests which may be utilised to define the entities of this tumour family will be evaluated in each diagnostic context.

中枢神经系统世界卫生组织第五次分类的一个新颖之处在于,它首次承认了儿科型弥漫性胶质瘤家族(包括高级别和低级别),从而突出了主要发生于儿童的胶质瘤的独特病理生物学基础。本综述将重点讨论儿科型弥漫性高级别胶质瘤家族,其中包括四种肿瘤类型:1)弥漫性中线胶质瘤 H3 K27-变异型;2)弥漫性半球胶质瘤 H3 G34-突变型;3)弥漫性儿科型高级别胶质瘤 H3-野生型和 IDH-野生型;以及 4)婴儿型半球胶质瘤。将讨论每种肿瘤类型的基本和理想诊断标准以及鉴别中的实体。将特别关注在日常实践中遇到的问题,尤其是关于弥漫性儿科型高级别胶质瘤 H3-野生型和 IDH-野生型的诊断。在每种诊断情况下,将评估可用于定义该肿瘤家族实体的多种分子检测的优势和局限性。
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引用次数: 0
Pulmonary mixed squamous and glandular papilloma: diagnostic challenges of a rare lesion when the clock is ticking. How to avoid interpretation mistakes. 肺混合性鳞状和腺状乳头状瘤:一种罕见病变的诊断挑战。如何避免口译错误。
IF 3.5 Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-809
Iteeka Arora, Nandita Gupta, M Angeles Montero, Patrizia Viola

Pulmonary mixed squamous and glandular papillomas (MSCGPs) are rare, benign neoplasms with peculiar clinical and histological features. However, on occasion, they can present certain characteristics that overlap with other neoplasms including carcinomas. Recognising these features is hence important for treatment purposes. Molecular studies can sometimes help in further characterisation, although they should not guide the diagnosis which ultimately relies on morphology.

We report a challenging case of MSCGP with unusual features, received during intraoperative consultation. We highlight the subtle morphological features to help avoid overcalling a benign lesion as malignant.

肺混合鳞状和腺状乳头状瘤(MSCGPs)是罕见的良性肿瘤,具有特殊的临床和组织学特征。然而,有时,它们可以表现出与其他肿瘤(包括癌)重叠的某些特征。因此,识别这些特征对于治疗非常重要。分子研究有时可以帮助进一步的特征,尽管它们不应该指导最终依赖于形态学的诊断。我们报告一个具有不寻常特征的MSCGP病例,在术中咨询期间收到。我们强调细微的形态学特征,以帮助避免将良性病变过度称为恶性病变。
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引用次数: 0
PD-L1 evaluation in the gastrointestinal tract: from biological rationale to its clinical application. 胃肠道PD-L1评价:从生物学原理到临床应用
IF 3.5 Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-803
Luca Mastracci, Federica Grillo, Paola Parente, Irene Gullo, Michela Campora, Valentina Angerilli, Chiara Rossi, Maria Luisa Sacramento, Gianmaria Pennelli, Alessandro Vanoli, Matteo Fassan

Immune-checkpoint inhibitors targeting the PD-1/PD-L1 axis have brought significant clinical benefit in many solid cancer types, including gastrointestinal malignancies. However, it has been estimated that only 20-40% of patients respond to treatment. The pattern of expression and potential predictive value of PD-L1 as an immunohistochemical biomarker has been extensively studied in gastrointestinal neoplasms. Until now, its predictive value has been demonstrated, and is currently in use only in upper gastrointestinal malignancies (gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma).

In this Review, we describe the technical aspects and challenges related to PD-L1 immunohistochemical assays, the current role of PD-L1 as a biomarker in clinical practice and we outline the main studies and clinical trials analyzing the prognostic and predictive value of PD-L1 in gastrointestinal cancers.

靶向PD-1/PD-L1轴的免疫检查点抑制剂在包括胃肠道恶性肿瘤在内的许多实体癌症类型中带来了显著的临床益处。然而,据估计,只有20-40%的患者对治疗有反应。PD-L1作为一种免疫组织化学生物标志物的表达模式和潜在的预测价值在胃肠道肿瘤中得到了广泛的研究。到目前为止,其预测价值已被证实,目前仅用于上消化道恶性肿瘤(胃食管腺癌和食管鳞状细胞癌)。在这篇综述中,我们描述了与PD-L1免疫组织化学分析相关的技术方面和挑战,PD-L1作为生物标志物在临床实践中的作用,我们概述了分析PD-L1在胃肠道癌症中的预后和预测价值的主要研究和临床试验。
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引用次数: 6
Primary intraosseous solitary fibrous tumor: an extremely rare case report and brief review of the literature. 原发性骨内孤立性纤维性肿瘤:一例极为罕见的病例报告及文献回顾。
IF 3.5 Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-524
Giulia Coppola, Carmine Zoccali, Jacopo Baldi, Alessio Annovazzi, Thedora Daralioti, Mariavittoria Vescovo, Renato Covello

Solitary fibrous tumor (SFT), a rare mesenchymal neoplasm of fibroblastic origin, was initially discovered in the mediastinal pleura and then described in many extra-pleural sites.

The reports of primary solitary fibrous tumor of bone are extremely rare and only a few cases have been previously mentioned in the literature, most of which in flat and short bones.

Here we present the case of a 53-year-old female, who was referred to the emergency department of a peripheral hospital after an accidental fall. Imaging studies revealed an intertrochanteric fracture with an underlying intramedullary lytic lesion. A biopsy was performed and a diagnosis of Ewing sarcoma was initially suggested. She arrived at our hospital where we reevaluated the case. The biopsy was reviewed and a diagnosis of intraosseous SFT was proposed. She underwent en-block resection of the proximal right femur.

Primary SFTs of the bone are, like in our case, easily misdiagnosed due to the low specificity of the imaging studies and the extreme rarity of the localization. An accurate diagnosis and early resection are very important and with careful long-term follow-up is essential, particularly in those who with malignant behavior, for the early detection of possible recurrence or metastasis.

孤立性纤维性肿瘤(SFT)是一种罕见的纤维母细胞间质肿瘤,最初发现于纵隔胸膜,后来在许多胸膜外部位也有报道。原发性骨孤立性纤维性肿瘤的报道极为罕见,文献中只报道过少数病例,且多发生在扁平骨和短骨。在这里,我们提出的情况下,53岁的女性,谁被转介到急诊室的外围医院意外跌倒后。影像学检查显示转子间骨折伴潜在髓内溶解性病变。活检后初步诊断为尤文氏肉瘤。她来到我们医院,我们重新评估了这个病例。我们回顾了活检并提出了骨内SFT的诊断。她接受了右股骨近端整块切除。像我们的病例一样,由于影像学研究的低特异性和定位的极端罕见,原发性骨SFTs很容易被误诊。准确的诊断和早期切除是非常重要的,仔细的长期随访是必不可少的,特别是对于那些有恶性行为的患者,早期发现可能的复发或转移。
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引用次数: 0
DOG-1 positive primary acinic cell carcinoma of the lung and investigation of molecular status. DOG-1阳性原发性肺腺泡细胞癌及其分子状态的研究。
IF 3.5 Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-786
Lorenzo Nibid, Luca Frasca, Giovanna Sabarese, Daniela Righi, Silvia Taccogna, Pierfilippo Crucitti, Paolo Graziano, Giuseppe Perrone

Primary acinic cell carcinoma (ACC) of the lung is an extremely rare neoplasm that more often arises near to a right bronchus. It is characterized by two populations of clear and dark eosinophilic cells, arranged in a glandular acinar pattern. Mitosis are rare and tumor cells show small and eccentric nuclei. Positive stain for PAS, PAS-D, cytokeratin, A1AT and A1ACT is reported, while TTF1, p40, synaptophysin, SMA, and S100 are substantially negative. DOG-1 positive stain was observed in ACC of the salivary glands and its negativity was proposed to distinguish between primary and metastatic ACC of the lung. Here, we report the 30th case of primary ACC of the lung, describing the immunohistochemical positivity for DOG-1 and the molecular status of the neoplasm for the first time.

原发性肺腺泡细胞癌(ACC)是一种极为罕见的肿瘤,多发生在右支气管附近。它的特点是两群透明和黑暗的嗜酸性细胞,排列在腺泡模式。有丝分裂罕见,肿瘤细胞核小且偏心。PAS、PAS- d、细胞角蛋白、A1AT和A1ACT染色呈阳性,而TTF1、p40、synaptophysin、SMA和S100基本呈阴性。在唾液腺ACC中观察到DOG-1阳性染色,并提出其阴性以区分原发性和转移性肺ACC。在这里,我们报告了第30例原发性肺ACC,首次描述了DOG-1的免疫组化阳性和肿瘤的分子状态。
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引用次数: 2
Metastatic mucinous ovarian carcinoma simulating lung primary: an integrated diagnostic lesson. 转移性黏液性卵巢癌模拟肺原发:一个综合的诊断教训。
IF 3.5 Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-802
Giuseppe Pelosi, Marco De Luca, Maria Cannone, Emanuela Balladore, Isabella Ricotti, Davide Toniolo, Matteo Incarbone

We herein document a rare instance of primary mucinous ovarian carcinoma metastatic to the left lung, whose deceptive secondary derivation was already envisaged according to the spectacular thromboembolism involving small pulmonary vessels, thereby realizing a centrifugal and centripetal metastatizing loop. This presentation was indicative of dismal prognosis. A multimodal biomarker key approach is herein emphasized, which included close clinico-pathologic data integration.

我们在此报告一例罕见的原发性黏液性卵巢癌转移至左肺的病例,根据壮观的血栓栓塞累及小肺血管,从而实现离心和向心转移循环,已经设想了其具有误导性的继发性起源。这种表现表明预后不佳。本文强调了一种多模式生物标志物关键方法,包括密切的临床病理数据整合。
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引用次数: 0
Pleural Kaposi sarcoma: an unusual clinical case. 胸膜卡波济肉瘤一例罕见的临床病例。
IF 3.5 Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-778
Alessandro Marando, Giuseppe Isimbaldi, Sascia Pietro Servillo, Emanuela Bonoldi

Kaposi sarcoma is a low-grade mesenchymal tumor associated with human herpesvirus-8. Here we describe the case of a 37-year old woman, who underwent to kidney and liver transplant for congenital hepatic fibrosis and bilateral polycystic kidney, with successive immunosuppressive therapy. After 5 years from first transplant, she developed cutaneous, mucosal, pleural and nodal localizations of Kaposi sarcoma, without lung lesions. Because of an initial clinical presentation with an important nodal and pleural involvement, a diagnosis of a lymphoproliferative disease was suspected. Pathological examination of the pleural sample allowed to exclude lymphoproliferative neoplasia and was consistent with Kaposi sarcoma. Subsequently involvement of other sites was diagnosed as expression of diffuse disease. The interest of this case lays in the unusual clinical presentation which can lead to diagnostic pitfalls when evaluating pleural biopsies.

卡波西肉瘤是一种与人类疱疹病毒-8相关的低级别间充质肿瘤。我们在此报告一位37岁的女性,因先天性肝纤维化和双侧多囊肾接受了两肾和肝脏移植,并接受了连续的免疫抑制治疗。第一次移植5年后,患者出现卡波西肉瘤的皮肤、粘膜、胸膜和淋巴结定位,未见肺部病变。由于最初的临床表现有重要的淋巴结和胸膜受累,我们怀疑诊断为淋巴增生性疾病。胸膜标本的病理检查排除了淋巴增生性肿瘤,与卡波西肉瘤一致。随后,其他部位受累被诊断为弥漫性疾病的表达。本病例的兴趣在于不寻常的临床表现,这可能导致诊断陷阱时,评估胸膜活检。
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引用次数: 0
Ecology and games in cancer: new insights into the disease. 癌症的生态学和博弈:对疾病的新见解。
IF 3.5 Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-798
Claudia Manini, José I López
This is an open access journal distributed in accordance with the CC-BY-NC-ND (Creative Commons AttributionNonCommercial-NoDerivatives 4.0 International) license: the work can be used by mentioning the author and the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons. org/licenses/by-nc-nd/4.0/deed.en PATHOLOGICA 2022;114:347-351; DOI: 10.32074/1591-951X-798
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引用次数: 0
What psammoma bodies can represent in the thyroid. What we recently learnt from a story of lack of evidence. 沙粒体在甲状腺中的表现。我们最近从一个缺乏证据的故事中学到了什么。
IF 3.5 Pub Date : 2022-10-01 DOI: 10.32074/1591-951X-815
Lina Cardisciani, Federica Policardo, Pietro Tralongo, Vincenzo Fiorentino, Esther Diana Rossi

The detection of psammoma bodies (PBs) in the thyroid gland is commonly associated to classic papillary thyroid carcinoma (PTC) and are frequently encountered in differnt subtypes of PTCs. Nonetheless, the evidence of PBs without a PTC may represent a diagnostic challenge. The general statement is that PBs represent a metastatic finding of PTC either when encountered inside the thyroid parenchyma or in the perithyroidal lymph nodes. The majority of authors assess that in presence of PBs, a search for an occult PTC is strongly encouraged and mandatory, especially if a lobectomy had been performed. In fact, it is not uncommon that a contralateral or ipsilateral tumor, mostly PTC, is found leading to the suggestion that the best recommendation is to submit the entire thyroid tissue. Nonetheless, when a cancer has not been found, the possibility of the rare evenience that PBs are likely to be associated with benign conditions should be considered among the differential diagnosis. Herein a short commentary and review of the literature on PBs detection and its diagnosis, based on our recent experience.

甲状腺沙粒小体(PBs)的检测通常与典型的甲状腺乳头状癌(PTC)相关,并且经常出现在不同亚型的PTC中。尽管如此,无PTC的PBs证据可能是一种诊断挑战。一般的说法是,当遇到甲状腺实质内或甲状腺周围淋巴结时,PBs代表PTC的转移发现。大多数作者评估,在PBs存在的情况下,强烈鼓励和强制搜索隐匿性PTC,特别是如果已经进行了肺叶切除术。事实上,发现对侧或同侧肿瘤(主要是PTC)并不罕见,因此建议最好的建议是提交整个甲状腺组织。尽管如此,当尚未发现癌症时,在鉴别诊断中应考虑PBs可能与良性疾病相关的罕见可能性。本文根据我们最近的经验,对PBs检测及其诊断的文献进行简短的评论和回顾。
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引用次数: 3
Primary adenosquamous carcinoma of the endometrium with glassy cell features. A diagnostic pitfall as a very rare tumour type in the endometrium. 原发性子宫内膜腺鳞癌具有玻璃状细胞特征。子宫内膜肿瘤是一种非常罕见的诊断缺陷。
IF 3.5 Pub Date : 2022-08-01 DOI: 10.32074/1591-951X-757
Selim Sevim, Duygu Enneli, Ezgi Dicle Serbes, Cevriye Cansiz Ersoz, Seher Yuksel

Primary adenosquamous carcinoma of the endometrium with glassy cell features (ASCGCF) is an extremely rare entity and to date, 16 cases of this entity have been reported in the literature. ASC-GCF is an aggressive histological subtype of cervical carcinoma with rapid growth and early metastases; however, very little is known about those originating from the endometrium as they are limited to only a few case reports. Herein, we report a case of primary adenosquamous carcinoma of the endometrium with extensive glassy cell features which posed a major diagnostic challenge by mimicking many entities with its histological diversity.

具有玻璃状细胞特征的原发性子宫内膜腺鳞癌(ASCGCF)是一种极其罕见的实体,迄今为止,文献中已报道了16例这种实体。ASC-GCF是一种快速生长和早期转移的侵袭性组织学亚型宫颈癌;然而,对于那些起源于子宫内膜的人知之甚少,因为它们仅限于少数病例报告。在此,我们报告一例原发性子宫内膜腺鳞癌,具有广泛的玻璃状细胞特征,通过模仿其组织学多样性的许多实体,构成了主要的诊断挑战。
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引用次数: 1
期刊
PATHOLOGICA
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