Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献

英文中文

Thirty years of Acta Dermatovenerologica Alpina Pannonica et Adriatica: from the journal’s beginnings to an impact factor 《亚得里亚海皮肤病性病学报》三十年:从期刊创刊到影响因子

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.15

Jovan Miljković, Anja Šterbenc

引用次数: 0

Molecular epidemiology of the 2022 monkeypox virus outbreak in Slovenia 斯洛文尼亚2022年猴痘病毒暴发的分子流行病学

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.21

Katarina Resman Rus, Samo Zakotnik, Martin Sagadin, Nataša Knap, Alen Suljič, Tomaž Mark Zorec, Maja Mastnak, Miroslav Petrovec, Mario Poljak, Misa Korva, Tatjana Avšič-Županc

Monkeypox virus (MPXV), typically endemic in West and Central Africa, has raised global concern due to the recent outbreak in several non-endemic countries with human-to-human transmission. Here we present a comprehensive analysis of MPXV genomes from Slovenia.Two real-time polymerase chain reaction (RT-PCR) assays for Orthopoxvirus (OPV) and MPXV genes were used for laboratory confirmation of mpox. Complete MPXV genomic sequences were obtained using nanopore long reads and Illumina technology. Phylogenetic analyses compared the Slovenian MPXV sequences with the global sequences.A total of 49 laboratory-confirmed mpox cases were diagnosed in Slovenia in 2022, mainly affecting males under 40. In 48 cases, a complete genome sequence was obtained and phylogenetic analysis revealed five distinct lineages (B.1, B.1.14, B.1.2, B.1.3, and A.2.1), with B.1 and B.1.3 dominating, suggesting multiple introductions into Slovenia. Genome analysis revealed significant divergence from the reference MPXV-M5312_HM12_Rivers.The genetic diversity observed in the Slovenian MPXV sequences sheds light on the complex dynamics of the 2022 mpox outbreak and highlights the need for further research to understand the impact of mutations on MPXV functional characteristics and their role in the evolution and diversification of current lineages.

猴痘病毒(MPXV)通常在西非和中非流行，由于最近在几个非流行国家暴发了人际传播，引起了全球关注。在这里，我们提出了对斯洛文尼亚MPXV基因组的全面分析。采用两种实时聚合酶链反应(RT-PCR)检测正痘病毒(OPV)和MPXV基因，对m痘进行实验室确认。利用纳米孔长读数和Illumina技术获得完整的MPXV基因组序列。系统发育分析比较了斯洛文尼亚MPXV序列与全球序列。2022年，斯洛文尼亚共诊断出49例经实验室确认的麻疹病例，主要影响40岁以下的男性。在48例中，获得了完整的基因组序列，系统发育分析显示了5个不同的谱系(B.1, B.1.14, B.1.2, B.1.3和a. 2.1)，其中B.1和B.1.3占主导地位，表明多次引入斯洛文尼亚。基因组分析显示与参考基因MPXV-M5312_HM12_Rivers存在显著差异。在斯洛文尼亚MPXV序列中观察到的遗传多样性揭示了2022年mpox暴发的复杂动态，并强调需要进一步研究以了解突变对MPXV功能特征的影响及其在当前谱系的进化和多样化中的作用。

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引用次数: 0

Analysis of the incidence of anogenital warts and serological test results for other sexually transmitted infections 肛门生殖器疣发病率及其他性传播感染血清学检测结果分析

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.17

Neşe Göçer Gürok

Anogenital warts (AGWs) are proliferative lesions mainly presenting in the anal, genital, and perianal regions. They are one of the most prevalent sexually transmitted infections globally.The study included patients that presented at the Dermatology Clinic of Health Sciences, University Elaziğ, Fethi Sekin City Hospital between January 2019 and December 2022 and were diagnosed with AGWs. Patients that presented with this diagnosis and were screened for other sexually transmitted infections (HBsAg, anti-HBs, anti-HCV, anti-HIV, VDRL, and TPHA) were identified. Epidemiological and demographic patient data and the results of serological tests for other sexually transmitted infections in the last 4 years were analyzed. The patient data and examination results were collected retrospectively based on the hospital automated patient records.AGW incidence was significantly higher in males. The mean patient age was 32, and the mean female patient age was lower than that of males. It was observed that the number of patients that were followed up with an AGW diagnosis increased significantly during the last 4 years (p < 0.05). The study detected 2.2% HBsAg, 0.6% TPHA, 0.3% VDRL, 0.5% anti-HCV, and 56.5% anti-HBs positivity. No anti-HIV-positive patients were identified. None of the patients had more than one sexually transmitted infection on serology testing.Although the serological findings were higher when compared to certain studies and quite low when compared to others, it would be beneficial to evaluate all patients with AGWs for other sexually transmitted infections.

肛门生殖器疣(agw)是一种主要出现在肛门、生殖器和肛周区域的增生性病变。它们是全球最普遍的性传播感染之一。该研究包括2019年1月至2022年12月期间在埃拉齐乌尔大学、费特希塞金市医院健康科学皮肤科诊所就诊的患者，并被诊断患有AGWs。提出这一诊断并筛查其他性传播感染(HBsAg, anti-HBs, anti-HCV, anti-HIV, VDRL和TPHA)的患者被确定。分析了过去4年的流行病学和人口学患者数据以及其他性传播感染的血清学检测结果。根据医院自动病历对患者资料和检查结果进行回顾性收集。男性的AGW发病率明显更高。患者平均年龄32岁，女性患者平均年龄低于男性。观察到，在过去4年中，诊断为AGW的患者随访人数显著增加(p < 0.05)。HBsAg阳性率为2.2%，TPHA阳性率为0.6%，VDRL阳性率为0.3%，抗hcv阳性率为0.5%，抗hbs阳性率为56.5%。未发现抗hiv阳性患者。血清学检测均无一例以上性传播感染。尽管与某些研究相比，血清学结果较高，而与其他研究相比，血清学结果相当低，但评估所有AGWs患者的其他性传播感染将是有益的。

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引用次数: 0

Positivity of celiac disease–specific antibodies and non-celiac hypersensitivity in psoriasis 牛皮癣患者乳糜泻特异性抗体阳性和非乳糜泻超敏反应

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.18

Marina Vekić-Mužević, Lucija Tomić, Nives Pondeljak, Elvira Lazić Mosler

Plaque psoriasis and celiac disease are multisystemic diseases. The association of psoriasis and enteropathy with histological changes similar to celiac disease has already been described, and it has also been found that a gluten-free diet improves psoriatic changes. This study assesses the relationship between celiac disease antibodies and psoriasis.The study included 112 participants: 60 with psoriasis in a test group and 52 healthy subjects in a control group. Within the psoriasis group, participants were further divided into two subgroups: one consisting of patients with both psoriasis and psoriatic arthritis (n = 17) and another comprising patients with psoriasis alone (n = 43). After informed consent was obtained, the Dermatology Life Quality Index (DLQI) score and Psoriasis Area and Severity Index (PASI) score were evaluated. Laboratory tests included assessment of anti-deaminated gliadin peptide antibodies (DGP), anti-gliadin antibodies (AGA), and anti-tissue transglutaminase antibodies (tTG).Immunoglobulin G (IgG) and immunoglobulin A (IgA) DGP antibodies were detected more frequently and at higher serum concentrations in patients with psoriasis compared to healthy controls (p = 0.03, p = 0.04, respectively). Similarly, elevated levels of IgG-tTG antibodies (p = 0.003) and IgA-DGP antibodies (p = 0.02) were observed in the same test group.A relationship between positivity to celiac disease antibodies and psoriasis, particularly with regard to AGA, has been identified. Further studies are required to elucidate the nature, pathophysiology, and significance of these findings.

斑块型银屑病和乳糜泻是多系统疾病。牛皮癣和肠病与乳糜泻类似的组织学变化之间的联系已经被描述过了，而且也发现无麸质饮食可以改善牛皮癣的变化。本研究评估乳糜泻抗体与牛皮癣之间的关系。这项研究包括112名参与者:60名牛皮癣患者作为试验组，52名健康受试者作为对照组。在牛皮癣组中，参与者被进一步分为两个亚组:一个由牛皮癣和银屑病关节炎患者组成(n = 17)，另一个由牛皮癣患者组成(n = 43)。在获得知情同意后，评估皮肤病生活质量指数(DLQI)评分和牛皮癣面积和严重程度指数(PASI)评分。实验室检测包括抗脱氨麦胶蛋白肽抗体(DGP)、抗麦胶蛋白抗体(AGA)和抗组织转谷氨酰胺酶抗体(tTG)的评估。与健康对照组相比，银屑病患者血清中免疫球蛋白G (IgG)和免疫球蛋白A (IgA) DGP抗体检测频率更高，血清浓度更高(p = 0.03, p = 0.04)。同样，同一试验组IgG-tTG抗体(p = 0.003)和IgA-DGP抗体(p = 0.02)水平升高。乳糜泻抗体阳性与牛皮癣之间的关系，特别是在AGA方面，已经确定。需要进一步的研究来阐明这些发现的性质、病理生理学和意义。

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引用次数: 0

Chronic radiation dermatitis induced by cardiac catheterization: a case report and literature review. 心导管置管诱发慢性放射性皮炎1例并文献复习。

IF 1.2 Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2022-12-01 DOI: 10.15570/actaapa.2022.25

Ting-Ting Cheng, Hui-Ju Yang

Fluoroscopy-induced chronic radiation dermatitis (FICRD) is an uncommon but increasing complication that is challenging to diagnose due to its varied symptoms and delayed onset, usually from months to years after radiation exposure. For patients undergoing cardiac catheterization, high-risk factors for radiodermatitis include obesity, the presence of complex or chronic total occlusion lesions, the use of a fixed large beam angulation, and a procedure time of more than 2 hours. We present an individual with FICRD that had an indurated plaque on his back for 7 years to familiarize physicians with high-risk groups and early recognition of the disease.

透视诱发的慢性放射性皮炎(FICRD)是一种罕见但日益增加的并发症，由于其多种症状和延迟发作(通常在辐射照射后数月至数年)，诊断具有挑战性。对于接受心导管插入术的患者，放射性皮炎的高危因素包括肥胖、存在复杂或慢性全闭塞病变、使用固定的大光束角度以及手术时间超过2小时。我们报告了一位背部有硬化斑块长达7年的FICRD患者，以使医生熟悉高危人群和早期识别该疾病。

引用次数: 0

A diagnostic challenge in an atypical variant of microcystic adnexal carcinoma mimicking ulcerative basal cell carcinoma: a case report and brief literature review. 模拟溃疡性基底细胞癌的微囊性附件癌的非典型变异的诊断挑战:一个病例报告和简短的文献复习。

IF 1.2 Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2022-12-01

Nurul Indah Pratiwi, Khairuddin Djawad, Jonathan Kurnia Wijaya, Mahmud Ghaznawie, Siswanto Wahab, Airin Nurdin

Microcystic adnexal carcinoma (MAC) is a rare adnexal tumor with eccrine and pillar differentiations with a localized and aggressive nature, often misdiagnosed as other dermatoses. The most common clinical manifestations of MAC are yellowish or skin-colored papules, nodules, and plaques. However, in some rare cases an atypical manifestation such as ulceration that resembles malignancies such as basal cell carcinoma (BCC) can also occur. Diagnosis of MAC mainly relies on the aid of histopathology. Due to potential infiltration to other structures such as in perineural invasion, wide surgical excision or Mohs micrographic surgery is the preferred surgical option. We report the case of a 75-year-old male patient with ulcerative lesion on the forehead that clinically resembled BCC in addition to typical dermoscopic findings of BCC. However, histopathology confirmed a diagnosis of MAC, prompting physicians to be more aware of this condition when encountering chronic ulcerative lesions. After wide excision and a 1-year follow-up, the patient exhibited no signs of recurrences and will continue long-term follow-up.

摘要微囊性附件癌(MAC)是一种罕见的附件肿瘤，具有内分泌和柱状分化，具有局限性和侵袭性，常被误诊为其他皮肤病。MAC最常见的临床表现是淡黄色或皮肤颜色的丘疹、结节和斑块。然而，在一些罕见的病例中，也会出现类似恶性肿瘤如基底细胞癌(BCC)的溃疡。MAC的诊断主要依靠组织病理学。由于潜在的浸润到其他结构，如神经周围的侵犯，广泛的手术切除或莫氏显微摄影手术是首选的手术选择。我们报告一例75岁男性患者的溃疡病变的额头，临床类似于BCC除了典型的皮肤镜检查结果的BCC。然而，组织病理学证实了MAC的诊断，这促使医生在遇到慢性溃疡性病变时更加注意这种情况。经大范围切除和1年随访，患者无复发迹象，将继续长期随访。

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引用次数: 0

Body-focused repetitive behaviors in children and adolescents, clinical characteristics, and the effects of treatment choices on symptoms: a single-center retrospective cohort study. 儿童和青少年以身体为中心的重复行为、临床特征和治疗选择对症状的影响:一项单中心回顾性队列研究

IF 1.2 Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2022-12-01 DOI: 10.15570/actaapa.2022.24

Zehra Topal Hangül, T. Tuman, Bengü Altunay-Tuman, Gizem Saygılı, A. Tufan

INTRODUCTIONThis study determines clinical features of body-focused repetitive behaviors (BFRBs) among a sample of Turkish children and adolescents, evaluates the naturalistic treatments selected in this sample, and determines the effects of those treatments during a 3-month follow-up.METHODSThe study included a cohort of 67 patients 9 to 17 years old attending a tertiary center between March and June 2013 with complaints of nail biting, skin picking, and/or hair pulling. The patients completed psychometric scales and were evaluated for symptom severity, improvement, and adverse effects after an initial interview and at control visits during the 4th and 8th weeks.RESULTSThe most common BFRB was nail biting. In nail-biting behavior, subjective awareness was higher, and urges prior to the behavior and release after the behavior were found to be higher. Although there was no significant difference between the choice of treatment and the course of psychiatric measures, significant improvement was found in functionality after treatment.CONCLUSIONSDespite its limitations, the small number of studies on BFRBs increases the importance of studies in this area.

本研究确定了土耳其儿童和青少年样本中身体聚焦重复行为(BFRBs)的临床特征，评估了该样本中选择的自然疗法，并在3个月的随访中确定了这些疗法的效果。方法本研究纳入了67例9至17岁的患者，于2013年3月至6月在三级中心就诊，主诉为咬指甲、抠皮肤和/或拔头发。患者完成心理测量量表，并在第4周和第8周的初次访谈和对照访问后评估症状严重程度、改善情况和不良反应。结果BFRB以咬指甲最为常见。在咬指甲行为中，主观意识较高，行为前的冲动和行为后的释放较高。虽然治疗方法的选择和精神病治疗过程之间没有显著差异，但治疗后的功能有显著改善。结论尽管有其局限性，但对bfrb的少量研究增加了该领域研究的重要性。

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引用次数: 0

Analysis of top-cited articles on melanoma. 关于黑色素瘤的热门文章分析。

IF 1.2 Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2022-12-01

Ka Siu Fan, Ka Hay Fan, Pak Lim Tse, Hao Ding, Runqing Su, Hiu Tat Kwok

Introduction: This bibliometric analysis evaluates the most influential studies in clinical research on melanoma.

Methods: Based on the bibliometric theory, articles in the Thomson Reuters Web of Science database were analyzed. Full English-language articles were searched for using the terms melanoma, superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma, and acral lentiginous melanoma. The 100 most-cited articles were analyzed by topic, author, journal of publication, year of publication, institution, and country of origin.

Results: The search returned 243,109 articles, with the majority from the past 3 decades: 1991-2000 (n = 29), 2001-2010 (n = 28), and 2011-2020 (n = 30). The top 100 cited articles had mean and median citations of 2,159 and 1,793, respectively. An article on the use of ipilimumab in metastatic melanoma, by Hodi et al., was most cited (8,150). The New England Journal of Medicine had the most citations (58,489), and Nature published the most articles (n = 21). The United States published the most articles (n = 81), led by the National Cancer Institute (n = 16). The majority of articles explored management (n = 68), prognosis (n = 57), and immunotherapy (n = 27).

Conclusions: This analysis serves as a guide for future research and highlights key areas of research, particularly in genetics and immunotherapy, that have influenced current knowledge of melanoma.

简介这项文献计量分析评估了黑色素瘤临床研究中最具影响力的研究：方法：根据文献计量学理论，对汤姆森路透社 Web of Science 数据库中的文章进行分析。使用黑色素瘤、浅表扩散性黑色素瘤、结节性黑色素瘤、恶性扁平苔藓黑色素瘤、尖状扁平苔藓黑色素瘤等术语搜索英文全文。按主题、作者、发表期刊、发表年份、机构和原籍国分析了被引用次数最多的 100 篇文章：结果：搜索结果共检索到243109篇文章，其中大部分来自过去30年：1991-2000年（29篇）、2001-2010年（28篇）和2011-2020年（30篇）。被引用次数最多的 100 篇文章的平均引用次数和中位数分别为 2,159 次和 1,793 次。Hodi等人撰写的一篇关于在转移性黑色素瘤中使用伊匹单抗的文章被引用最多（8150次）。新英格兰医学杂志》的引用次数最多（58,489次），《自然》杂志发表的文章最多（21篇）。美国发表的文章最多（81 篇），其中以国家癌症研究所（16 篇）为首。大多数文章探讨了管理（68 篇）、预后（57 篇）和免疫疗法（27 篇）：本分析可作为未来研究的指南，并强调了影响当前黑色素瘤知识的关键研究领域，尤其是遗传学和免疫疗法领域。

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引用次数: 0

Immunity after mRNA COVID-19 vaccine and immunosuppressive therapy: correspondence. mRNA - COVID-19疫苗和免疫抑制治疗后的免疫:对应关系。

IF 1.2 Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2022-12-01 DOI: 10.15570/actaapa.2022.27

R. Mungmunpuntipantip, V. Wiwanitkit

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引用次数: 0

Immunity after mRNA COVID-19 vaccine and immunosuppressive therapy: correspondence. mRNA - COVID-19疫苗和免疫抑制治疗后的免疫:对应关系。

IF 1.2 Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2022-12-01

Rujittika Mungmunpuntipantip, Viroj Wiwanitkit

引用次数: 0

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