Acta Dermatovenerologica Alpina Pannonica et Adriatica最新文献

英文中文

Safety and efficacy of intralesional injection of enalapril versus triamcinolone acetonide in the treatment of keloids 病灶内注射依那普利与曲安奈德治疗瘢痕疙瘩的安全性和有效性比较

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.16

Basma Hamada Mohamed, Samar Eltahlawy, Walaa Ahmed Marzouk, Noha E. Mohamad

Keloids are pathologic conditions characterized by fibroblast hyper-proliferation and excess collagen deposition. Enalapril, one of the angiotensin-converting enzyme inhibitors, has recently been highlighted as a new therapeutic modality in treating keloids. This study evaluates the effectiveness of intralesional injection of enalapril versus triamcinolone acetonide (TAA) in keloids.Forty patients with multiple keloids were enrolled in our study. Enalapril and TAA were injected intralesionally in one session per month for three sessions. The clinical outcomes were assessed via the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS).In both groups, according to VSS and POSAS, there was a high statistically significant difference (p-value ≤ 0.01) before treatment, at the end of each session, and 3 months after treatment. There was no significant difference between both groups regarding degree of improvement. Patients treated with TAA developed more significant complications than those in the enalapril group (p-value < 0.05).Both enalapril and TAA had the same clinical effect. Enalapril could be a safe alternative to steroids in the treatment of keloid and hypertrophic scars. Further studies on enalapril are needed on a large sample of patients with further focus on the mechanism of this innovative drug.

瘢痕疙瘩是一种以成纤维细胞过度增生和过多胶原沉积为特征的病理状态。依那普利是血管紧张素转换酶抑制剂之一，近年来作为治疗瘢痕疙瘩的一种新的治疗方式而受到重视。本研究评价瘢痕疙瘩病灶内注射依那普利与曲安奈德(TAA)的疗效。40例多发性瘢痕疙瘩患者参加了我们的研究。依那普利和TAA静脉注射，每月一次，共3次。临床结果通过温哥华疤痕量表(VSS)和患者和观察者疤痕评估量表(POSAS)进行评估。根据VSS和POSAS，两组在治疗前、每次治疗结束时和治疗后3个月的差异均有很高的统计学意义(p值≤0.01)。两组在改善程度上无显著差异。TAA组患者并发症发生率高于依那普利组(p值< 0.05)。依那普利与TAA的临床疗效相同。依那普利可能是一种安全的替代类固醇治疗瘢痕疙瘩和增生性疤痕。对依那普利的进一步研究需要在大样本患者中进行，进一步关注这种创新药物的机制。

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引用次数: 0

Swelling of inguinal lymph nodes in a patient with HIV: a case report HIV患者腹股沟淋巴结肿大1例报告

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.23

Mark Sergej Bartenjev, Maja Mastnak, Darja Keše, Andreja Murnik Rauh

Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by the L1, L2, and L3 serotypes of Chlamydia trachomatis (CT). It primarily affects regional lymph nodes. Although it is not endemic in Europe and North America, recent reports indicate an increasing prevalence among men who have sex with men, with proctocolitis as the most frequently reported symptom. We report the case of a homosexual male that presented to our department with a nodular lesion on the shaft of the penis and tender, enlarged inguinal lymph nodes. Throat, urethral, and rectal swabs were collected for CT testing using real-time polymerase chain reaction. The urethral swab was positive for CT, whereas the throat and rectal swabs were negative. Subsequent testing detected the presence of LGV DNA. The patient was treated with a prolonged course of doxycycline. After 6 weeks, the urethral swab for CT returned a negative result. The patient reported complete remission 7 weeks after the start of treatment.

性病性淋巴肉芽肿(LGV)是一种由沙眼衣原体(CT) L1、L2和L3血清型引起的性传播感染。它主要影响局部淋巴结。虽然它在欧洲和北美并不流行，但最近的报告表明，在男男性行为的男性中患病率越来越高，直结肠炎是最常见的报告症状。我们报告的情况下，一名同性恋男子，提出了一个结节性病变的阴茎轴和柔软，扩大腹股沟淋巴结。收集喉部、尿道和直肠拭子，采用实时聚合酶链反应进行CT检测。尿道拭子CT阳性，喉部和直肠拭子CT阴性。随后的测试检测到LGV DNA的存在。患者接受了延长疗程的强力霉素治疗。6周后，尿道拭子CT结果为阴性。患者在开始治疗7周后报告完全缓解。

引用次数: 0

Colocalizing paraneoplastic alopecia areata and nodular basal cell carcinoma 副肿瘤性斑秃和结节性基底细胞癌的共定位

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.24

Martina Lambertini, Costantino Ricci, Bor Hrvatin Stancic, Martina Mussi, Barbara Corti, Cosimo Misciali, Bianca Maria Piraccini, Emi Dika

1IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 2Dermatology Unit, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy. 3Pathology Unit, Maggiore Hospital-AUSL Bologna, Bologna, Italy. 4Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. 5Dermatovenerology Department, Ljubljana University Medical Center, Ljubljana, Slovenia. 6Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. 7Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria Policlinico di Sant'Orsola, University of Bologna, Bologna, Italy.

引用次数: 0

HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013 1989-2013年斯洛文尼亚HIV-1亚型多样性和非b亚型传播的系统发育观察

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.20

Jana Mlakar, Maja M. Lunar, Ana B. Abecasis, Anne-Mieke Vandamme, Janez Tomažič, Tomaž D. Vovko, Blaž Pečavar, Gabriele Turel, Mario Poljak

Disease progression, drug resistance mutations, and treatment strategies may vary by HIV-1 subtype. This study determined HIV-1 subtypes circulating in Slovenia, a Central European country with an HIV-1 epidemic driven by men who have sex with men, focusing on molecular epidemiology of non-B subtypes.A total of 367 HIV-1 sequences were included. Subtype was assigned by employing eight different HIV subtyping tools coupled with maximum likelihood phylogenetic analyses.The subtyping tools COMET, jpHMM, and REGA 3.0 exhibited the best performance on the dataset studied. Phylogenetic analyses showed a 14.7% prevalence of non-B subtypes, with subtype A detected most frequently (4.9%), followed by CRF02_AG (2.4%), subtype C (1.1%), subtypes D, G, and CRF01_AE (0.8% each), and subtypes F and CRF22_01A1 (0.3% each). A subtype could not be assigned to 12 sequences (3.3%), indicating potential unique recombinant forms. Non-B subtypes were significantly associated with a heterosexual route of transmission and infection acquired in Eastern Europe, Africa, or Asia.In a country where subtype B is predominant, non-B subtypes were observed in one out of seven patients, a non-negligible proportion, which underlines the importance of systematic surveillance of HIV subtype diversity and the corresponding molecular epidemiology.

疾病进展、耐药突变和治疗策略可能因HIV-1亚型而异。本研究确定了在中欧国家斯洛文尼亚流行的HIV-1亚型，该国家HIV-1流行由男男性行为者驱动，重点关注非b亚型的分子流行病学。共包含367个HIV-1序列。通过采用8种不同的HIV亚型分型工具以及最大似然系统发育分析来确定亚型。在所研究的数据集上，亚型工具COMET、jpHMM和REGA 3.0表现出最好的性能。系统发育分析显示，非b亚型的患病率为14.7%，其中a亚型最多(4.9%)，其次是CRF02_AG (2.4%)， C亚型(1.1%)，D、G和CRF01_AE亚型(各0.8%)，F和CRF22_01A1亚型(各0.3%)。有12个序列(3.3%)不能找到一个亚型，表明可能存在独特的重组形式。在东欧、非洲或亚洲，非b亚型与异性恋传播途径和感染显著相关。在一个以B亚型为主的国家，非B亚型在七分之一的患者中观察到，这是一个不可忽视的比例，这强调了系统监测艾滋病毒亚型多样性和相应的分子流行病学的重要性。

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引用次数: 0

Thirty years of Acta Dermatovenerologica Alpina Pannonica et Adriatica: from the journal’s beginnings to an impact factor 《亚得里亚海皮肤病性病学报》三十年:从期刊创刊到影响因子

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.15

Jovan Miljković, Anja Šterbenc

引用次数: 0

Molecular epidemiology of the 2022 monkeypox virus outbreak in Slovenia 斯洛文尼亚2022年猴痘病毒暴发的分子流行病学

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.21

Katarina Resman Rus, Samo Zakotnik, Martin Sagadin, Nataša Knap, Alen Suljič, Tomaž Mark Zorec, Maja Mastnak, Miroslav Petrovec, Mario Poljak, Misa Korva, Tatjana Avšič-Županc

Monkeypox virus (MPXV), typically endemic in West and Central Africa, has raised global concern due to the recent outbreak in several non-endemic countries with human-to-human transmission. Here we present a comprehensive analysis of MPXV genomes from Slovenia.Two real-time polymerase chain reaction (RT-PCR) assays for Orthopoxvirus (OPV) and MPXV genes were used for laboratory confirmation of mpox. Complete MPXV genomic sequences were obtained using nanopore long reads and Illumina technology. Phylogenetic analyses compared the Slovenian MPXV sequences with the global sequences.A total of 49 laboratory-confirmed mpox cases were diagnosed in Slovenia in 2022, mainly affecting males under 40. In 48 cases, a complete genome sequence was obtained and phylogenetic analysis revealed five distinct lineages (B.1, B.1.14, B.1.2, B.1.3, and A.2.1), with B.1 and B.1.3 dominating, suggesting multiple introductions into Slovenia. Genome analysis revealed significant divergence from the reference MPXV-M5312_HM12_Rivers.The genetic diversity observed in the Slovenian MPXV sequences sheds light on the complex dynamics of the 2022 mpox outbreak and highlights the need for further research to understand the impact of mutations on MPXV functional characteristics and their role in the evolution and diversification of current lineages.

猴痘病毒(MPXV)通常在西非和中非流行，由于最近在几个非流行国家暴发了人际传播，引起了全球关注。在这里，我们提出了对斯洛文尼亚MPXV基因组的全面分析。采用两种实时聚合酶链反应(RT-PCR)检测正痘病毒(OPV)和MPXV基因，对m痘进行实验室确认。利用纳米孔长读数和Illumina技术获得完整的MPXV基因组序列。系统发育分析比较了斯洛文尼亚MPXV序列与全球序列。2022年，斯洛文尼亚共诊断出49例经实验室确认的麻疹病例，主要影响40岁以下的男性。在48例中，获得了完整的基因组序列，系统发育分析显示了5个不同的谱系(B.1, B.1.14, B.1.2, B.1.3和a. 2.1)，其中B.1和B.1.3占主导地位，表明多次引入斯洛文尼亚。基因组分析显示与参考基因MPXV-M5312_HM12_Rivers存在显著差异。在斯洛文尼亚MPXV序列中观察到的遗传多样性揭示了2022年mpox暴发的复杂动态，并强调需要进一步研究以了解突变对MPXV功能特征的影响及其在当前谱系的进化和多样化中的作用。

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引用次数: 0

Analysis of the incidence of anogenital warts and serological test results for other sexually transmitted infections 肛门生殖器疣发病率及其他性传播感染血清学检测结果分析

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.17

Neşe Göçer Gürok

Anogenital warts (AGWs) are proliferative lesions mainly presenting in the anal, genital, and perianal regions. They are one of the most prevalent sexually transmitted infections globally.The study included patients that presented at the Dermatology Clinic of Health Sciences, University Elaziğ, Fethi Sekin City Hospital between January 2019 and December 2022 and were diagnosed with AGWs. Patients that presented with this diagnosis and were screened for other sexually transmitted infections (HBsAg, anti-HBs, anti-HCV, anti-HIV, VDRL, and TPHA) were identified. Epidemiological and demographic patient data and the results of serological tests for other sexually transmitted infections in the last 4 years were analyzed. The patient data and examination results were collected retrospectively based on the hospital automated patient records.AGW incidence was significantly higher in males. The mean patient age was 32, and the mean female patient age was lower than that of males. It was observed that the number of patients that were followed up with an AGW diagnosis increased significantly during the last 4 years (p < 0.05). The study detected 2.2% HBsAg, 0.6% TPHA, 0.3% VDRL, 0.5% anti-HCV, and 56.5% anti-HBs positivity. No anti-HIV-positive patients were identified. None of the patients had more than one sexually transmitted infection on serology testing.Although the serological findings were higher when compared to certain studies and quite low when compared to others, it would be beneficial to evaluate all patients with AGWs for other sexually transmitted infections.

肛门生殖器疣(agw)是一种主要出现在肛门、生殖器和肛周区域的增生性病变。它们是全球最普遍的性传播感染之一。该研究包括2019年1月至2022年12月期间在埃拉齐乌尔大学、费特希塞金市医院健康科学皮肤科诊所就诊的患者，并被诊断患有AGWs。提出这一诊断并筛查其他性传播感染(HBsAg, anti-HBs, anti-HCV, anti-HIV, VDRL和TPHA)的患者被确定。分析了过去4年的流行病学和人口学患者数据以及其他性传播感染的血清学检测结果。根据医院自动病历对患者资料和检查结果进行回顾性收集。男性的AGW发病率明显更高。患者平均年龄32岁，女性患者平均年龄低于男性。观察到，在过去4年中，诊断为AGW的患者随访人数显著增加(p < 0.05)。HBsAg阳性率为2.2%，TPHA阳性率为0.6%，VDRL阳性率为0.3%，抗hcv阳性率为0.5%，抗hbs阳性率为56.5%。未发现抗hiv阳性患者。血清学检测均无一例以上性传播感染。尽管与某些研究相比，血清学结果较高，而与其他研究相比，血清学结果相当低，但评估所有AGWs患者的其他性传播感染将是有益的。

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引用次数: 0

Positivity of celiac disease–specific antibodies and non-celiac hypersensitivity in psoriasis 牛皮癣患者乳糜泻特异性抗体阳性和非乳糜泻超敏反应

Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2023-01-01 DOI: 10.15570/actaapa.2023.18

Marina Vekić-Mužević, Lucija Tomić, Nives Pondeljak, Elvira Lazić Mosler

Plaque psoriasis and celiac disease are multisystemic diseases. The association of psoriasis and enteropathy with histological changes similar to celiac disease has already been described, and it has also been found that a gluten-free diet improves psoriatic changes. This study assesses the relationship between celiac disease antibodies and psoriasis.The study included 112 participants: 60 with psoriasis in a test group and 52 healthy subjects in a control group. Within the psoriasis group, participants were further divided into two subgroups: one consisting of patients with both psoriasis and psoriatic arthritis (n = 17) and another comprising patients with psoriasis alone (n = 43). After informed consent was obtained, the Dermatology Life Quality Index (DLQI) score and Psoriasis Area and Severity Index (PASI) score were evaluated. Laboratory tests included assessment of anti-deaminated gliadin peptide antibodies (DGP), anti-gliadin antibodies (AGA), and anti-tissue transglutaminase antibodies (tTG).Immunoglobulin G (IgG) and immunoglobulin A (IgA) DGP antibodies were detected more frequently and at higher serum concentrations in patients with psoriasis compared to healthy controls (p = 0.03, p = 0.04, respectively). Similarly, elevated levels of IgG-tTG antibodies (p = 0.003) and IgA-DGP antibodies (p = 0.02) were observed in the same test group.A relationship between positivity to celiac disease antibodies and psoriasis, particularly with regard to AGA, has been identified. Further studies are required to elucidate the nature, pathophysiology, and significance of these findings.

斑块型银屑病和乳糜泻是多系统疾病。牛皮癣和肠病与乳糜泻类似的组织学变化之间的联系已经被描述过了，而且也发现无麸质饮食可以改善牛皮癣的变化。本研究评估乳糜泻抗体与牛皮癣之间的关系。这项研究包括112名参与者:60名牛皮癣患者作为试验组，52名健康受试者作为对照组。在牛皮癣组中，参与者被进一步分为两个亚组:一个由牛皮癣和银屑病关节炎患者组成(n = 17)，另一个由牛皮癣患者组成(n = 43)。在获得知情同意后，评估皮肤病生活质量指数(DLQI)评分和牛皮癣面积和严重程度指数(PASI)评分。实验室检测包括抗脱氨麦胶蛋白肽抗体(DGP)、抗麦胶蛋白抗体(AGA)和抗组织转谷氨酰胺酶抗体(tTG)的评估。与健康对照组相比，银屑病患者血清中免疫球蛋白G (IgG)和免疫球蛋白A (IgA) DGP抗体检测频率更高，血清浓度更高(p = 0.03, p = 0.04)。同样，同一试验组IgG-tTG抗体(p = 0.003)和IgA-DGP抗体(p = 0.02)水平升高。乳糜泻抗体阳性与牛皮癣之间的关系，特别是在AGA方面，已经确定。需要进一步的研究来阐明这些发现的性质、病理生理学和意义。

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引用次数: 0

Chronic radiation dermatitis induced by cardiac catheterization: a case report and literature review. 心导管置管诱发慢性放射性皮炎1例并文献复习。

IF 1.2 Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2022-12-01 DOI: 10.15570/actaapa.2022.25

Ting-Ting Cheng, Hui-Ju Yang

Fluoroscopy-induced chronic radiation dermatitis (FICRD) is an uncommon but increasing complication that is challenging to diagnose due to its varied symptoms and delayed onset, usually from months to years after radiation exposure. For patients undergoing cardiac catheterization, high-risk factors for radiodermatitis include obesity, the presence of complex or chronic total occlusion lesions, the use of a fixed large beam angulation, and a procedure time of more than 2 hours. We present an individual with FICRD that had an indurated plaque on his back for 7 years to familiarize physicians with high-risk groups and early recognition of the disease.

透视诱发的慢性放射性皮炎(FICRD)是一种罕见但日益增加的并发症，由于其多种症状和延迟发作(通常在辐射照射后数月至数年)，诊断具有挑战性。对于接受心导管插入术的患者，放射性皮炎的高危因素包括肥胖、存在复杂或慢性全闭塞病变、使用固定的大光束角度以及手术时间超过2小时。我们报告了一位背部有硬化斑块长达7年的FICRD患者，以使医生熟悉高危人群和早期识别该疾病。

引用次数: 0

A diagnostic challenge in an atypical variant of microcystic adnexal carcinoma mimicking ulcerative basal cell carcinoma: a case report and brief literature review. 模拟溃疡性基底细胞癌的微囊性附件癌的非典型变异的诊断挑战:一个病例报告和简短的文献复习。

IF 1.2 Q4 DERMATOLOGY

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Pub Date : 2022-12-01

Nurul Indah Pratiwi, Khairuddin Djawad, Jonathan Kurnia Wijaya, Mahmud Ghaznawie, Siswanto Wahab, Airin Nurdin

Microcystic adnexal carcinoma (MAC) is a rare adnexal tumor with eccrine and pillar differentiations with a localized and aggressive nature, often misdiagnosed as other dermatoses. The most common clinical manifestations of MAC are yellowish or skin-colored papules, nodules, and plaques. However, in some rare cases an atypical manifestation such as ulceration that resembles malignancies such as basal cell carcinoma (BCC) can also occur. Diagnosis of MAC mainly relies on the aid of histopathology. Due to potential infiltration to other structures such as in perineural invasion, wide surgical excision or Mohs micrographic surgery is the preferred surgical option. We report the case of a 75-year-old male patient with ulcerative lesion on the forehead that clinically resembled BCC in addition to typical dermoscopic findings of BCC. However, histopathology confirmed a diagnosis of MAC, prompting physicians to be more aware of this condition when encountering chronic ulcerative lesions. After wide excision and a 1-year follow-up, the patient exhibited no signs of recurrences and will continue long-term follow-up.

摘要微囊性附件癌(MAC)是一种罕见的附件肿瘤，具有内分泌和柱状分化，具有局限性和侵袭性，常被误诊为其他皮肤病。MAC最常见的临床表现是淡黄色或皮肤颜色的丘疹、结节和斑块。然而，在一些罕见的病例中，也会出现类似恶性肿瘤如基底细胞癌(BCC)的溃疡。MAC的诊断主要依靠组织病理学。由于潜在的浸润到其他结构，如神经周围的侵犯，广泛的手术切除或莫氏显微摄影手术是首选的手术选择。我们报告一例75岁男性患者的溃疡病变的额头，临床类似于BCC除了典型的皮肤镜检查结果的BCC。然而，组织病理学证实了MAC的诊断，这促使医生在遇到慢性溃疡性病变时更加注意这种情况。经大范围切除和1年随访，患者无复发迹象，将继续长期随访。

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