Egyptian Rheumatologist最新文献_第6页

Elbow joint involvement in rheumatoid arthritis patients: Clinical and ultrasound findings of the neglected joint 类风湿关节炎患者肘关节受累：被忽视关节的临床和超声表现

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist

Pub Date : 2025-01-19 DOI: 10.1016/j.ejr.2025.01.003

Samar Tharwat , Ahmed Hassan , Sherin Z Mohamed

Aim

of the work.

To assess the role of musculoskeletal ultrasound (MSUS) in the evaluation of elbow joint abnormalities in rheumatoid arthritis (RA) patients.

Patients and methods

This study was conducted on 47 RA patients subjected to clinical assessment and MSUS of both elbows.

Results

The mean age of the patients was 44 ± 9.55 years, they were 42 females, and 5 males and rheumatoid factor was positive in 76.6 %. This work was conducted on 94 elbow joints (59.6 % asymptomatic, 8.5 % unilateral, and 31.9 % bilateral joint pain). Ultrasound (US) abnormalities were present in 61 (64.9 %) of scanned joints. Effusion/synovial hypertrophy was the most common abnormality (31.9 %), followed by structural abnormalities at the common extensor tendon (26.6 %). There was a significant difference between symptomatic and asymptomatic elbow joints regarding US abnormalities of the elbows. MSUS showed high sensitivity and specificity in detection of elbow pathology compared to physical examination as the following: biceps tendon pathology (98.81 % specificity, 40 % sensitivity), effusion/synovial hypertrophy (62.32 % specificity, 68 % sensitivity), lateral epicondylitis (71.43 % specificity, 76.47 % sensitivity), medial epicondylitis (71.95 % specificity, 66.67 % sensitivity), and triceps enthesopathy (73.33 % specificity, 50 % sensitivity). Moderate agreement was observed for biceps tendon pathology (κ = 0.5, p < 0.001). Fair agreement was noted for effusion/synovial hypertrophy (κ = 0.25, p = 0.009). Similarly, fair agreement was observed for lateral epicondylitis (κ = 0.34, p < 0.001) and medial epicondylitis (κ = 0.23, p = 0.008). Although triceps enthesopathy showed only slight to no agreement between clinical examination and US (κ = 0.06, p = 0.31).

Conclusion

Elbow problems are frequent among individuals with RA, even in those who do not exhibit overt elbow symptoms.

工作的目的。目的探讨肌肉骨骼超声（MSUS）在类风湿关节炎（RA）患者肘关节异常诊断中的作用。患者和方法本研究对47例RA患者进行了临床评估和双肘MSUS。结果患者平均年龄44±9.55岁，其中女性42例，男性5例，类风湿因子阳性占76.6%。这项工作对94个肘关节进行了研究，其中59.6%无症状，8.5%单侧，31.9%双侧关节疼痛。超声（US）异常存在于61（64.9%）扫描关节。积液/滑膜肥厚是最常见的异常（31.9%），其次是总伸肌腱的结构异常（26.6%）。有症状和无症状肘关节的US异常有显著差异。MSUS检测肘关节病变的灵敏度和特异性均高于体格检查：肱二头肌肌腱病变（特异性98.81%，敏感性40%）、积液/滑膜肥厚（特异性62.32%，敏感性68%）、外上髁炎（特异性71.43%，敏感性76.47%）、内上髁炎（特异性71.95%，敏感性66.67%）、肱三头肌骨髓炎（特异性73.33%，敏感性50%）。二头肌肌腱病理结果有中等程度的一致性(κ = 0.5, p <；0.001)。积液/滑膜肥厚的结果一致（κ = 0.25, p = 0.009）。同样，外上髁炎的结果也一致(κ = 0.34, p <；0.001)和内侧上髁炎（κ = 0.23, p = 0.008）。虽然三头肌骨骺病变在临床检查和US之间只有轻微或没有一致（κ = 0.06, p = 0.31）。结论：即使在没有明显肘部症状的RA患者中，肘部问题也很常见。

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引用次数: 0

Expression patterns of ciRS-7 and miR-7 in peripheral blood mononuclear cells of rheumatoid arthritis patients 类风湿关节炎患者外周血单个核细胞中ciRS-7和miR-7的表达规律

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist

Pub Date : 2025-01-17 DOI: 10.1016/j.ejr.2024.12.006

Doaa M. El-Wakil , Aya M. Nasr , Alaa R. Awad , Iman H. Bassyouni , Nadia M.H. Madany

Background: Non-coding RNAs (ncRNAs), including miR-7 and ciRS-7, are implicated in many autoimmune diseases, but their roles in rheumatoid arthritis (RA) stay largely unexplored. Aim of the work: To assess miR-7 and ciRS-7 as diagnostic biomarkers for RA by comparing their expression patterns in patients vs. controls and correlating their profiles with anti-cyclic citrullinated peptide (anti-CCP) levels and clinical findings. Patients and methods: Forty-five patients and 45 controls were enrolled. Enzyme-linked immunosorbent assay (ELISA) was performed to assess plasma anti-CCP levels, and reverse transcription polymerase chain reaction (RT-PCR) was conducted to determine miR-7 and ciRS-7 expression levels. Results: All cases were female with a mean age of 39.6 ± 10.2 years. Cases exhibited significantly lower levels of miR-7 expression than control (median, 0.51 vs. 1.03; p < 0.001), while a significant elevation in ciRS-7 was observed in cases (median, 4.29 vs. 0.93; p < 0.001). Neither miR-7 nor ciRS-7 showed a significant correlation with anti-CCP levels. Meanwhile, miR-7 and ciRS-7 levels significantly correlated with the duration of RA (r_s = 0.32, p = 0.03; r_s = 0.4, p = 0.01, respectively), while the anti-CCP levels demonstrated a significant negative correlation with disease duration (r_s= −0.33, p = 0.03). miR-7 and ciRS-7 significantly distinguish cases from controls at cut-off values of < 0.81 and > 1.7, respectively (AUC = 0.98 and 0.99; p < 0.001), and their combination achieved 100 % diagnostic accuracy, with an AUC of 1 (p < 0.001). Conclusions: miR-7 and ciRS-7 have an inverse relationship, suggesting that ciRS-7 could modulate miR-7 regulatory functions. Both miR-7 and ciRS-7 could be used as diagnostic biomarkers for RA, and their combination could improve RA prediction.

背景：包括miR-7和ciRS-7在内的非编码rna （ncRNAs）与许多自身免疫性疾病有关，但它们在类风湿关节炎（RA）中的作用在很大程度上尚未被探索。研究目的：通过比较miR-7和ciRS-7在患者和对照组中的表达模式，并将其与抗环瓜氨酸肽（anti-CCP）水平和临床表现相关联，评估miR-7和ciRS-7作为RA的诊断性生物标志物。患者和方法：纳入45例患者和45例对照。采用酶联免疫吸附试验（ELISA）评估血浆抗ccp水平，采用逆转录聚合酶链反应（RT-PCR）检测miR-7和ciRS-7表达水平。结果：所有病例均为女性，平均年龄39.6±10.2岁。病例的miR-7表达水平明显低于对照组(中位数，0.51 vs. 1.03；p & lt;0.001)，而在病例中观察到ciRS-7显著升高(中位数，4.29 vs. 0.93；p & lt;0.001)。miR-7和ciRS-7与抗ccp水平均无显著相关性。miR-7、ciRS-7水平与RA病程显著相关(rs = 0.32, p = 0.03；rs= 0.4, p = 0.01)，而抗ccp水平与病程呈显著负相关（rs= - 0.33, p = 0.03）。miR-7和ciRS-7在临界值<上显著区分病例与对照组；0.81和>；分别为1.7 (AUC = 0.98和0.99)；p & lt;0.001)，其组合达到100%的诊断准确率，AUC为1 (p <；0.001)。结论：miR-7与ciRS-7呈反比关系，表明ciRS-7可以调节miR-7的调控功能。miR-7和ciRS-7都可以作为RA的诊断性生物标志物，它们的结合可以提高RA的预测。

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引用次数: 0

GNG11mRNA and long non-coding RNA PEBP1-1:1: Emerging role in axial spondyloarthritis patients GNG11mRNA和长链非编码RNA PEBP1-1:1：在轴性脊柱炎患者中的新作用

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist

Pub Date : 2025-01-16 DOI: 10.1016/j.ejr.2024.12.004

Basma R. Sakr , Laila A. Rashed , Shams M. Reda , Walaa Ibrahim

Aim of the work: To evaluate expression of Guanine nucleotide binding protein gamma 11(GNG11) mRNA and long non-coding (lnc) RNA PEBP1-1:1 in axial spondyloarthritis (axSpA) patients and to appraise their probable relation with disease manifestations and activity. Patients and methods: This study included 50 axSpA patients and 50 controls. Disease activity was evaluated using BASDAI. Radiographic X ray grading of lumbar spine and sacroiliacs was appraised using BASRI and The New York sacroiliitis radiological grading criteria. Quantitative analysis of expression of GNG11mRNA and lnc RNA PEBP1-1:1 by real- time PCR was accomplished. Results: The mean age of axSpA patients was 37.3 ± 10 years. AxSpA patients exhibited significantly increased expression of GNG11 mRNA and lnc RNA PEBP1-1:1 compared to controls (p < 0.001 each). There was no difference in GNG11 mRNA and lnc RNA PEBP1:1 between patients with high and low BASDAI (p = 0.49, p = 0.71). The expression of GNG11 mRNA and lnc RNA PEBP1:1 did not show difference between radiological grades of lumbosacral spine (p = 0.76, p = 0.34), or sacroiliacs (p = 0.92, p = 0.74). There was a significant reverse relationship between lnc RNA PEBP1:1 expression levels and lateral bending test (right side: r = -0.32, p = 0.03) (left side: r = -0.38, p = 0.01). There was no association between the expression level of GNG11 mRNA or lnc RNA PEBP1:1 and either disease duration, BASDAI, or radiographic grading. Conclusion: Upregulated expression of GNG11 mRNA and lncRNA PEBP1-1:1 in axSpA patients suggests their role as key regulators of the molecular pathogenesis of axSpA, yet they were not related to diseases activity or radiographic grading.

目的：研究鸟嘌呤核苷酸结合蛋白γ - 11(GNG11) mRNA和长链非编码（lnc） RNA PEBP1-1:1在轴性脊柱炎（axSpA）患者中的表达及其与疾病表现和活动的可能关系。患者和方法：本研究包括50例axSpA患者和50例对照组。采用BASDAI评估疾病活动性。采用BASRI和纽约骶髂炎放射学分级标准评价腰椎和骶髂关节的X线片分级。采用real- time PCR定量分析GNG11mRNA和lnc RNA PEBP1-1:1的表达。结果：axSpA患者平均年龄37.3±10岁。与对照组相比，AxSpA患者GNG11 mRNA和lnc RNA PEBP1-1:1的表达显著增加(p <；0.001每个)。高、低BASDAI患者GNG11 mRNA和lnc RNA PEBP1:1差异无统计学意义（p = 0.49, p = 0.71）。GNG11 mRNA和lnc RNA PEBP1:1的表达在腰骶棘（p = 0.76, p = 0.34）和骶髂（p = 0.92, p = 0.74）的放射学分级之间无差异。lnc RNA PEBP1:1表达量与侧弯试验呈显著负相关（右侧：r = -0.32, p = 0.03）（左侧：r = -0.38, p = 0.01）。GNG11 mRNA或lnc RNA PEBP1:1的表达水平与病程、BASDAI或影像学分级均无相关性。结论：GNG11 mRNA和lncRNA PEBP1-1:1在axSpA患者中表达上调，提示它们是axSpA分子发病的关键调控因子，但与疾病活动性和影像学分级无关。

{"title":"GNG11mRNA and long non-coding RNA PEBP1-1:1: Emerging role in axial spondyloarthritis patients","authors":"Basma R. Sakr , Laila A. Rashed , Shams M. Reda , Walaa Ibrahim","doi":"10.1016/j.ejr.2024.12.004","DOIUrl":"10.1016/j.ejr.2024.12.004","url":null,"abstract":"<div><div><em>Aim of the work:</em> To evaluate expression of Guanine nucleotide binding protein gamma 11(GNG11) mRNA and long non-coding (lnc) RNA PEBP1-1:1 in axial spondyloarthritis (axSpA) patients and to appraise their probable relation with disease manifestations and activity. <em>Patients and methods:</em> This study included 50 axSpA patients and 50 controls. Disease activity was evaluated using BASDAI. Radiographic X ray grading of lumbar spine and sacroiliacs was appraised using BASRI and The New York sacroiliitis radiological grading criteria. Quantitative analysis of expression of GNG11mRNA and lnc RNA PEBP1-1:1 by real- time PCR was accomplished. <em>Results:</em> The mean age of axSpA patients was 37.3 ± 10 years. AxSpA patients exhibited significantly increased expression of GNG11 mRNA and lnc RNA PEBP1-1:1 compared to controls (p < 0.001 each). There was no difference in GNG11 mRNA and lnc RNA PEBP1:1 between patients with high and low BASDAI (p = 0.49, p = 0.71). The expression of GNG11 mRNA and lnc RNA PEBP1:1 did not show difference between radiological grades of lumbosacral spine (p = 0.76, p = 0.34), or sacroiliacs (p = 0.92, p = 0.74). There was a significant reverse relationship between lnc RNA PEBP1:1 expression levels and lateral bending test (right side: r = -0.32, p = 0.03) (left side: r = -0.38, p = 0.01). There was no association between the expression level of GNG11 mRNA or lnc RNA PEBP1:1 and either disease duration, BASDAI, or radiographic grading. <em>Conclusion:</em> Upregulated expression of GNG11 mRNA and lncRNA PEBP1-1:1 in axSpA patients suggests their role as key regulators of the molecular pathogenesis of axSpA, yet they were not related to diseases activity or radiographic grading.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 2","pages":"Pages 70-73"},"PeriodicalIF":1.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed onset lupus nephritis in the course of systemic lupus erythematosus: Relation to disease activity and therapeutic response 系统性红斑狼疮病程中的迟发性狼疮肾炎：与疾病活动性和治疗反应的关系

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist

Pub Date : 2025-01-16 DOI: 10.1016/j.ejr.2024.12.005

Eman M. Elhabashy, Wafaa H. Hussein, Geilan A. Mahmoud

Background: Lupus nephritis (LN) is severe organ involvement in systemic lupus erythematosus (SLE). It could be the first presentation, commonly in the first year after diagnosis, but may arise later during the disease course. The time of LN onset can affect its clinical presentation and disease outcomes. Aim of the work: To study the differences between early and delayed onset LN during the course of SLE and the prognosis of the disease. Patients and methods: This study included 100 SLE patients with LN. They were categorized into early onset group who developed LN within one year of diagnosis and delayed onset LN if developed after one year. Renal response to treatment was compared between early and delayed-onsets LN cases after six months, one year and two years of following up. Results: This study involved 100 SLE patient, 93 females and 7 males, the mean age was 36.6 ± 8.6 years with disease duration 9.7 ± 5.03 years. Early onset LN group included 45 patients while delayed-onset group included 55. At baseline, ESR and SELENA-SLEDAI were higher (p = 0.017 and 0.016 respectively) in early onset and renal biopsy showed higher cellular and fibrous crescents in the same group (p = 0.045 and 0.012 respectively). On the other hand, delayed onset LN group after 6 months, 1 and 2 years of following up showed more frequent flares with incomplete remission (p < 0.001, p = 0.002 and p < 0.001 respectively) and higher SELENA-SLEDAI (p < 0.001). Conclusion: Early onset LN has a better treatment response and presents a valuable indicator of complete remission than delayed-onset LN.

背景：狼疮肾炎（LN）是系统性红斑狼疮（SLE）的严重脏器累及。它可能是第一次出现，通常在诊断后的第一年，但也可能在病程的后期出现。LN的发病时间可影响其临床表现和疾病结局。研究目的：探讨SLE病程中早发性和晚发性LN的差异及其预后。患者和方法：本研究纳入100例SLE合并LN患者。他们被分为早发组，即在诊断一年内发展为LN，而迟发组则在一年后发展为LN。在随访6个月、1年和2年后，比较早期和迟发性LN患者对治疗的肾脏反应。结果：100例SLE患者，女性93例，男性7例，平均年龄36.6±8.6岁，病程9.7±5.03年。早发性LN组45例，迟发性LN组55例。在基线时，早期发病的ESR和SELENA-SLEDAI更高（p分别= 0.017和0.016），同一组的肾活检显示更高的细胞和纤维新月（p分别= 0.045和0.012）。另一方面，迟发性LN组在随访6个月、1年和2年后出现更频繁的不完全缓解(p <；0.001, p = 0.002, p <；0.001)和更高的SELENA-SLEDAI (p <；0.001)。结论：早发性LN具有更好的治疗效果，是迟发性LN完全缓解的重要指标。

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引用次数: 0

Axial involvement in a cohort of patients with psoriatic arthritis 银屑病关节炎患者的轴向受累

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist

Pub Date : 2025-01-16 DOI: 10.1016/j.ejr.2025.01.002

Nermeen Samy, Adel M. El Sayed, Sherin H. Hamza, Fatma Ibrahim, Dalia M. Gamal

Aim of the work: To assess the characteristics of axial involvement in psoriatic arthritis (PsA) patients and to determine risk factors and relation to disease characteristics. Patients and methods: A hundred patients with PsA were studied, classified into two groups according to axial affection. Disease activity in PsA (DAPSA), Bath ankylosing spondylitis disease activity index (BASDAI), axial spondyloarthritis disease activity (ASDAS), psoriatic arthritis Ratingen score (PARS), psoriatic arthritis spondylitis radiology index (BASRI), Bath ankylosing spondylitis metrology index (BASMI), Bath ankylosing functional index (BASFI), health assessment questionnaire (HAQ) and visual analogue scale (VAS) scores were implemented. Results: They were 65 females and 35 males (F:M 1.9:1) with a mean age of 41.6 ± 11.85 years.49 % had axial affection versus 51 % with peripheral affection. Comparing both groups revealed significant association of axial involvement with smoking (p = 0.032), PsA duration (p < 0.001), family history of skin psoriasis or arthritis (p = 0.002), dactylitis (p = 0.036), enthesitis (p < 0.001), BASDAI (p = 0.027), DAPSA (p = 0.003), BASMI (p < 0.0001), BASFI (p = 0.016), HAQ (p < 0.0001), and VAS (p < 0.001) scores. Positive predictors of axial PsA included smoking (p = 0.035), disease onset of skin psoriasis at ≤ 18 years (p < 0.0001), PsA duration > 6 years (p < 0.0001), family history of psoriasis/PsA (p = 0.004), enthesitis (p = 0.001), dactylitis (p = 0.04), CRP > 23 (p = 0.007), DAPSA score > 42 (p = 0.001), BASDAI score > 4.2 (p = 0.003), BASMI score > 0.9 (p < 0.0001). Conclusion: Axial PsA is more frequent in smokers, patients with prolonged disease duration, a positive family history, a higher incidence of enthesitis and dactylitis, raised activity, radiographic and functional scores.

工作目的：评估银屑病关节炎（PsA）患者轴向受累的特征，确定危险因素及其与疾病特征的关系。患者与方法：对100例PsA患者进行研究，根据轴向关系分为两组。采用PsA （DAPSA）、巴斯强直性脊柱炎疾病活动性指数（BASDAI）、轴向性脊柱炎疾病活动性（ASDAS）、银屑病关节炎Ratingen评分（PARS）、银屑病关节炎脊柱炎放射学指数（BASRI）、巴斯强直性脊柱炎计量学指数（BASMI）、巴斯强直性功能指数（BASFI）、健康评估问卷（HAQ）和视觉模拟量表（VAS）评分。结果：女性65例，男性35例，男女比例为1.9:1，平均年龄41.6±11.85岁。49%有轴向病变，51%有外周病变。两组比较发现轴位受累与吸烟（p = 0.032）、PsA持续时间(p <；0.001)，皮肤牛皮癣或关节炎家族史（p = 0.002），指突炎（p = 0.036），鼻炎(p <；0.001), BASDAI (p = 0.027), DAPSA (p = 0.003), BASMI (p & lt;0.0001), BASFI (p = 0.016), HAQ (p <；0.0001), VAS (p <；0.001)分数。轴向PsA的阳性预测因子包括吸烟（p = 0.035）、年龄≤18岁的牛皮癣发病(p <；0.0001)， PsA时间>；6年(p <；0.0001)、银屑病家族史/PsA （p = 0.004）、鼻炎（p = 0.001）、指突炎（p = 0.04）、CRP >；23 (p = 0.007)， DAPSA评分>；42 (p = 0.001)， BASDAI评分>；4.2 (p = 0.003)， BASMI评分>；0.9 (p <；0.0001)。结论：轴向PsA多发于吸烟、病程延长、家族史阳性、鼻炎和趾炎发生率高、活动度、影像学和功能评分增高的患者。

{"title":"Axial involvement in a cohort of patients with psoriatic arthritis","authors":"Nermeen Samy, Adel M. El Sayed, Sherin H. Hamza, Fatma Ibrahim, Dalia M. Gamal","doi":"10.1016/j.ejr.2025.01.002","DOIUrl":"10.1016/j.ejr.2025.01.002","url":null,"abstract":"<div><div><strong>Aim of the work:</strong> To assess the characteristics of axial involvement in psoriatic arthritis (PsA) patients and to determine risk factors and relation to disease characteristics. <strong>Patients and methods</strong>: A hundred patients with PsA were studied, classified into two groups according to axial affection. Disease activity in PsA (DAPSA), Bath ankylosing spondylitis disease activity index (BASDAI), axial spondyloarthritis disease activity (ASDAS), psoriatic arthritis Ratingen score (PARS), psoriatic arthritis spondylitis radiology index (BASRI), Bath ankylosing spondylitis metrology index (BASMI), Bath ankylosing functional index (BASFI), health assessment questionnaire (HAQ) and visual analogue scale (VAS) scores were implemented. <strong>Results</strong>: They were 65 females and 35 males (F:M 1.9:1) with a mean age of 41.6 ± 11.85 years.49 % had axial affection versus 51 % with peripheral affection. Comparing both groups revealed significant association of axial involvement with smoking (p = 0.032), PsA duration (p < 0.001), family history of skin psoriasis or arthritis (p = 0.002), dactylitis (p = 0.036), enthesitis (p < 0.001), BASDAI (p = 0.027), DAPSA (p = 0.003), BASMI (p < 0.0001), BASFI (p = 0.016), HAQ (p < 0.0001), and VAS (p < 0.001) scores. Positive predictors of axial PsA included smoking (p = 0.035), disease onset of skin psoriasis at ≤ 18 years (p < 0.0001), PsA duration > 6 years (p < 0.0001), family history of psoriasis/PsA (p = 0.004), enthesitis (p = 0.001), dactylitis (p = 0.04), CRP > 23 (p = 0.007), DAPSA score > 42 (p = 0.001), BASDAI score > 4.2 (p = 0.003), BASMI score > 0.9 (p < 0.0001). <strong>Conclusion</strong>: Axial PsA is more frequent in smokers, patients with prolonged disease duration, a positive family history, a higher incidence of enthesitis and dactylitis, raised activity, radiographic and functional scores.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 2","pages":"Pages 74-79"},"PeriodicalIF":1.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uveitis in spondyloarthritis patients: Relation to clinical characteristics 颈椎病患者葡萄膜炎：与临床特征的关系

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist

Pub Date : 2025-01-15 DOI: 10.1016/j.ejr.2025.01.001

Hanan M. Farouk , Amina B. Abdelaziz , Mohammad A. Rashad , Nashwa A. Morshedy , Madonna H. Gad , Dalia A. ElSherbiny

Aim of the work

To assess the prevalence of uveitis in SpA patients and determine its association with clinical manifestations, laboratorial, radiological, and therapeutic data.

Patients and methods

This work included 81 adult SpA patients. Detailed medical history was taken. Full clinical and ophthalmological examinations were performed.

Results

The mean age of patients was 37.4 ± 9.3 years, 51 males and 30 females with positive family history of SpA in 18.5 %. 22 (27.2 %) had uveitis which was anterior in 18 (81.8 %), posterior in 5 (22.7 %), acute in 15 (68.2 %), unilateral in 15 (68.2 %). Regarding ophthalmology examination, 3 (3.7 %) had cataract, 1 (1.2 %) had glaucoma, 1 (1.2 %) had visual loss and 2 (2.5 %) had ocular surgery. In univariate analysis, there was significant association between uveitis and age, family history, erythrocyte sedimentation rate (ESR) > 28 mm/1^sthr, C-reactive protein (CRP) > 11 mg/dl, hemoglobin ≤ 11.2 g/dl, white blood cell count (WBCs) > 7.5 ×10³/mm³, platelets > 345 ×10³/mm³, human leucocytic antigen (HLA-B27) and sacroiliitis. In multivariate analysis, there was significant association between uveitis and age (p = 0.061), ESR > 28 mm/1^sthr (p = 0.023), CRP > 11 mg/dl (p = 0.018), hemoglobin ≤ 11.2 g/dl (p = 0.015), platelets > 345 ×10³/mm³ (p = 0.059) and sacroiliitis (p = 0.024).

Conclusion

Uveitis in patients with SpA is common especially with increase in age. With a positive family history of SpA and/or long disease duration, occurrence of uveitis should not be neglected. Uveitis is related also to inflammatory markers, HLA-B27 and sacroiliitis. Routine screening for uveitis in SpA patients is crucial for better early disease management.

研究目的评估SpA患者葡萄膜炎的患病率，并确定其与临床表现、实验室、放射学和治疗数据的关系。患者与方法本研究纳入81例成人SpA患者。记录了详细的病史。进行了全面的临床和眼科检查。结果患者平均年龄37.4±9.3岁，男性51例，女性30例，家族史阳性占18.5%。22例（27.2%）有葡萄膜炎，其中前型18例（81.8%），后型5例（22.7%），急性型15例（68.2%），单侧15例（68.2%）。眼科检查中，白内障3例（3.7%），青光眼1例（1.2%），视力下降1例（1.2%），眼部手术2例（2.5%）。在单因素分析中，葡萄膜炎与年龄、家族史、红细胞沉降率（ESR）和gt有显著相关；28mm / 1thr， c反应蛋白（CRP） >；11 mg/dl，血红蛋白≤11.2 g/dl，白细胞计数（WBCs） >；7.5 ×103/mm3，血小板；345 ×103/mm3，人白细胞抗原（HLA-B27）和骶髂炎。在多因素分析中，葡萄膜炎与年龄有显著相关性（p = 0.061）， ESR >；28 mm/ 1thr (p = 0.023), CRP >；11 mg / dl (p = 0.018),血红蛋白≤11.2 g / dl (p = 0.015),血小板比;345 ×103/mm3 （p = 0.059）和骶髂炎（p = 0.024）。结论葡萄膜炎在SpA患者中较为常见，且随年龄的增长而增加。有SpA阳性家族史和/或病程长，不应忽视葡萄膜炎的发生。葡萄膜炎也与炎症标志物、HLA-B27和骶髂炎有关。SpA患者的葡萄膜炎常规筛查对于更好的早期疾病管理至关重要。

{"title":"Uveitis in spondyloarthritis patients: Relation to clinical characteristics","authors":"Hanan M. Farouk , Amina B. Abdelaziz , Mohammad A. Rashad , Nashwa A. Morshedy , Madonna H. Gad , Dalia A. ElSherbiny","doi":"10.1016/j.ejr.2025.01.001","DOIUrl":"10.1016/j.ejr.2025.01.001","url":null,"abstract":"<div><h3>Aim of the work</h3><div>To assess the prevalence of uveitis in SpA patients and determine its association with clinical manifestations, laboratorial, radiological, and therapeutic data.</div></div><div><h3>Patients and methods</h3><div>This work included 81 adult SpA patients. Detailed medical history was taken. Full clinical and ophthalmological examinations were performed.</div></div><div><h3>Results</h3><div>The mean age of patients was 37.4 ± 9.3 years, 51 males and 30 females with positive family history of SpA in 18.5 %. 22 (27.2 %) had uveitis which was anterior in 18 (81.8 %), posterior in 5 (22.7 %), acute in 15 (68.2 %), unilateral in 15 (68.2 %). Regarding ophthalmology examination, 3 (3.7 %) had cataract, 1 (1.2 %) had glaucoma, 1 (1.2 %) had visual loss and 2 (2.5 %) had ocular surgery. In univariate analysis, there was significant association between uveitis and age, family history, erythrocyte sedimentation rate (ESR) > 28 mm/1<sup>st</sup>hr, C-reactive protein (CRP) > 11 mg/dl, hemoglobin ≤ 11.2 g/dl, white blood cell count (WBCs) > 7.5 ×10<sup>3</sup>/mm<sup>3</sup>, platelets > 345 ×10<sup>3</sup>/mm<sup>3</sup>, human leucocytic antigen (HLA-B27) and sacroiliitis. In multivariate analysis, there was significant association between uveitis and age (p = 0.061), ESR > 28 mm/1<sup>st</sup>hr (p = 0.023), CRP > 11 mg/dl (p = 0.018), hemoglobin ≤ 11.2 g/dl (p = 0.015), platelets > 345 ×10<sup>3</sup>/mm<sup>3</sup> (p = 0.059) and sacroiliitis (p = 0.024).</div></div><div><h3>Conclusion</h3><div>Uveitis in patients with SpA is common especially with increase in age. With a positive family history of SpA and/or long disease duration, occurrence of uveitis should not be neglected. Uveitis is related also to inflammatory markers, HLA-B27 and sacroiliitis. Routine screening for uveitis in SpA patients is crucial for better early disease management.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 2","pages":"Pages 61-64"},"PeriodicalIF":1.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma high-mobility group nucleosome-binding domain 1 (HMGN1) protein levels in four common rheumatic diseases: A potential biomarker of rheumatoid arthritis 四种常见风湿病的血浆高迁移率核小体结合结构域1 （HMGN1）蛋白水平：类风湿关节炎的潜在生物标志物

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist

Pub Date : 2025-01-05 DOI: 10.1016/j.ejr.2024.12.003

Evgeny A. Ermakov , Anna S. Tolmacheva , Vadim V. Kon’kov , Mark M. Melamud , Alexey E. Sizikov , Nataliya A. Klyaus , Georgy A. Nevinsky , Valentina N. Buneva

Aim of the work: Non-histone chromosomal protein, high-mobility group nucleosome-binding domain 1 (HMGN1), is assumed to be a potential alarmin involved in the activation of inflammatory responses in rheumatic diseases, but the blood concentration of this protein is unknown. In this study, the plasma concentration of HMGN1 was investigated in four common rheumatic diseases compared to healthy individuals and between diseases. Patients and methods: A total of 39 age-matched rheumatoid arthritis (RA) patients, 64 ankylosing spondylitis (AS) patients, 30 psoriatic arthritis (PsA) patients, 26 systemic lupus erythematosus (SLE) patients and 59 healthy subjects were included in the study. HMGN1 concentration was determined by enzyme-linked immunosorbent assay. Results: HMGN1 concentration was above the minimum detectable level in 7 % of healthy individuals, 12 % of SLE, 17 % of PsA, 36 % of AS, and 82 % of RA patients. The remaining participants had HMGN1 concentrations close to zero. The odds ratio for HMGN1 detection in RA was 62.9 (95 % CI: 17.1–231.4, p < 0.00001) and in AS was 7.7 (95 % CI: 2.5–24.0, p = 0.00008). The median HMGN1 concentration in RA (1.36 [Q1, Q3: 0.21, 2.85]) was significantly higher than in healthy individuals (0 [0,0] ng/mL, p < 0.00001) and patients with other rheumatic diseases (p < 0.00001). HMGN1 levels were also increased in AS patients (0 [0, 0.21] ng/mL, p = 0.00006) compared to controls, but to a lesser extent than in RA. HMGN1 concentration in SLE and PsA patients did not differ from healthy subjects. HMGN1 showed good diagnostic potential as a predictor of RA patients and healthy individuals (AUC: 0.87, 95 %CI: 0.79–0.95, p < 0.00001). HMGN1 level correlated only with DAS28 score in RA (r = 0.44, p = 0.02), although multiple regression analysis identified only erythrocyte sedimentation rate as a predictor of DAS28 but not HMGN1 level. Conclusion: HMGN1 can be considered as a promising differential biomarker of RA. More sensitive tests for HMGN1 levels are needed for accurate diagnosis. Furthermore, studies on the role of HMGN1 in RA pathogenesis are needed in light of these findings.

工作目的：非组蛋白染色体蛋白，高迁移率核小体结合结构域1 (HMGN1)，被认为是参与风湿性疾病炎症反应激活的潜在警报蛋白，但该蛋白的血药浓度尚不清楚。在本研究中，研究了四种常见风湿病患者血浆HMGN1浓度与健康人及疾病间的比较。患者与方法：共纳入年龄匹配的类风湿关节炎（RA）患者39例，强直性脊柱炎（AS）患者64例，银屑病关节炎（PsA）患者30例，系统性红斑狼疮（SLE）患者26例，健康受试者59例。采用酶联免疫吸附法测定HMGN1浓度。结果：在7%的健康个体、12%的SLE、17%的PsA、36%的AS和82%的RA患者中，HMGN1浓度高于最低可检测水平。其余参与者的HMGN1浓度接近于零。HMGN1在RA中检测的优势比为62.9 (95% CI: 17.1-231.4, p <；0.00001)， AS组为7.7 （95% CI: 2.5 ~ 24.0, p = 0.00008）。RA组HMGN1中位浓度（1.36 [Q1, Q3: 0.21, 2.85]）显著高于健康组(0 [0,0]ng/mL, p <；0.00001)和其他风湿病患者(p <；0.00001)。与对照组相比，AS患者HMGN1水平也升高（0 [0,0.21]ng/mL, p = 0.00006），但低于RA患者。SLE和PsA患者的HMGN1浓度与健康人无显著差异。HMGN1作为RA患者和健康人的良好诊断预测因子(AUC: 0.87, 95% CI: 0.79-0.95, p <；0.00001)。HMGN1水平仅与RA的DAS28评分相关（r = 0.44, p = 0.02），尽管多元回归分析发现只有红细胞沉降率是DAS28的预测因子，而不是HMGN1水平。结论：HMGN1可作为类风湿关节炎的鉴别标志物。为了准确诊断，需要对HMGN1水平进行更灵敏的检测。因此，还需要进一步研究HMGN1在RA发病机制中的作用。

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引用次数: 0

Musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis patients 类风湿关节炎患者一级亲属的肌肉骨骼超声表现

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist

Pub Date : 2025-01-05 DOI: 10.1016/j.ejr.2024.12.002

Safaa A. Hussein, Abdelazim M. El-Hefny, Caroline S. Morad, Bassant MI Hassanin, Mohamed RM Abdelkader

Aim of the work: To determine the frequency of subclinical joint and/or tendon affection using high resolution ultrasonography in healthy first-degree relatives (FDRs) of patients with rheumatoid arthritis (RA) and the relation to serological markers. Patients and methods: This work was conducted on 60 subjects with high risk of developing arthritis; healthy FDRs of patients with RA. Clinical assessment, laboratory investigations and high-resolution musculoskeletal ultrasound (MSUS) were done. Seven joints of the clinically dominant foot and hand had been evaluated by ultrasound in grayscale and Doppler flow employing the ultrasound 7 (US7) scoring system. The US7 score evaluated the following joints: wrists, metacarpophalangeal (MCP) II and III, proximal interphalangeal (PIP) II and III, and metatarsophalangeal (MTP) II and V, which had been examined for tenosynovitis/para-tenonitis, synovitis, and erosions. Results: Rheumatoid factor (RF) was positive in four FDRs (6.7%) had, two (3.3%) had positive anti-cyclic citrullinated peptide (anti-CCP) antibodies, MSUS positive findings had been identified in 31 FDRs (51.6%); of whom 18 (58%) had arthralgia. Synovitis by Gray Scale was the commonest finding, as it was recorded in 31 FDRs (51.6%), tenosynovitis/para-tenonitis was present in 2 (3.3%) FDRs. There were no erosions detected in all subjects. The wrist was the most frequently affected joint in 23 subjects (38.3%) on MSUS.RF gives the best AUC being (67%), followed by anti-CCP (52%), then the arthralgia. Conclusion: This work is in line with the notion of FDRs being pre-RA. MSUS serves as an effective screening instrument for detecting subclinical synovitis among at risk individuals.

目的：应用高分辨率超声检测类风湿关节炎（RA）患者健康一级亲属（FDRs）亚临床关节和/或肌腱病变的频率及其与血清学指标的关系。患者和方法：这项工作是在60名患关节炎的高风险受试者中进行的；RA患者的健康fdr临床评估，实验室检查和高分辨率肌肉骨骼超声（MSUS）。采用超声7 （US7）评分系统对临床优势足、手7个关节进行灰度和多普勒血流评价。US7评分评估了以下关节：手腕，掌指关节（MCP） II和III，近端指间关节（PIP） II和III，跖指关节（MTP） II和V，检查了腱鞘炎/腱鞘旁炎，滑膜炎和糜烂。结果：类风湿因子（RF）阳性4例（6.7%），抗环瓜氨酸肽（anti-CCP）抗体阳性2例（3.3%），MSUS阳性31例（51.6%）；其中18人（58%）患有关节痛。灰度级滑膜炎是最常见的发现，31例fdr（51.6%）记录了滑膜炎，2例（3.3%）fdr存在腱鞘炎/腱鞘旁炎。所有受试者均未发现糜烂。腕部是23例（38.3%）MSUS患者中最常受影响的关节。RF给予最佳AUC(67%)，其次是抗ccp(52%)，最后是关节痛。结论：这项工作符合fdr是pre-RA的概念。MSUS作为一种有效的筛查工具，用于检测亚临床滑膜炎的危险个体。

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引用次数: 0

Assessment of serum interleukin-20 and interleukin-33 levels in rheumatoid arthritis patients 类风湿关节炎患者血清白细胞介素-20和白细胞介素-33水平的评价

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist

Pub Date : 2025-01-01 DOI: 10.1016/j.ejr.2024.12.001

Shimaa A. Abdel Salam , Fatma elzahraa Y. Fathy , Rasha N. Thabet , Nagwa M. Abo El Magd

Background

Understanding the role of cytokines in progression and pathogenesis of rheumatoid arthritis (RA) may help in development of new treatment strategies.

Aim of the work

To detect the interleukin–20 (IL-20) and interleukin-33 (IL-33) serum levels in RA patients and to assess their relationship with disease activity.

Patients and methods

This study was done on 30 RA patients and 30 matched controls. Disease activity score (DAS 28) was assessed. Level of IL-20 and IL-33 were measured by using Enzyme linked immunosorbent assay.

Results

The level of IL-20 and IL-33 were significantly elevated in the RA patients (37 ± 17.8 ng/L and 102.6 ± 17.5 ng/L) compared to controls (13.6 ± 1.9 ng/L and 44.6 ± 10.5 ng/L; p < 0.001 for both) and level of each cytokine was significantly changed according to DAS 28 disease activity score. ROC curve analysis demonstrated that both IL-20 and IL-23 had excellent diagnostic accuracy in differentiation of RA patients from healthy controls with 80 % and 93.3 % sensitivity and 80 % and 83.3 % specificity respectively. Also, IL33 level was considered an accurate discriminating marker between RA patients and controls. Regression analysis highlights that DAS-28 is predictor for both IL-20 and IL-33.

Conclusion

A significant higher levels of serum IL-20 and IL-33 was observed in RA patients, and both were associated with the disease activity. Also, IL-33 was effective in differentiation between RA cases and controls. These findings indicate that IL-20 and IL-33 could be useful biomarkers for assessing disease activity in RA and both may serve as potential targets for future treatment of the disease.

背景了解细胞因子在类风湿关节炎（RA）进展和发病机制中的作用可能有助于开发新的治疗策略。目的检测RA患者血清白细胞介素-20 （IL-20）和白细胞介素-33 （IL-33）水平并探讨其与疾病活动度的关系。患者和方法本研究在30名RA患者和30名匹配的对照组中进行。评估疾病活动评分（DAS 28）。采用酶联免疫吸附法检测IL-20、IL-33水平。结果RA患者血清IL-20和IL-33水平分别为37±17.8 ng/L和102.6±17.5 ng/L，显著高于对照组（13.6±1.9 ng/L和44.6±10.5 ng/L）；p & lt;根据DAS 28疾病活动性评分，各细胞因子水平均发生显著变化。ROC曲线分析显示，IL-20和IL-23对RA患者与健康对照的鉴别诊断准确率较高，敏感性分别为80%和93.3%，特异性分别为80%和83.3%。此外，IL33水平被认为是区分RA患者和对照组的准确标记。回归分析表明DAS-28是IL-20和IL-33的预测因子。结论RA患者血清IL-20和IL-33水平明显升高，且两者与RA的活动性相关。此外，IL-33在区分RA病例和对照组方面是有效的。这些发现表明，IL-20和IL-33可能是评估RA疾病活动性的有用生物标志物，两者都可能作为未来治疗RA疾病的潜在靶点。

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引用次数: 0

Heart rate variability stands up to bedside tests and composite autonomic symptom score-31 (COMPASS-31) questionnaire: Diagnostic tools for autonomic dysfunction in systemic sclerosis patients 心率变异性通过床边测试和自主神经症状综合评分-31 （COMPASS-31）问卷：系统性硬化症患者自主神经功能障碍的诊断工具

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist

Pub Date : 2024-11-30 DOI: 10.1016/j.ejr.2024.11.004

Gehad G. Maghraby , Alshaimaa S Khalil , May MT Fawzi , Mohamed T Hegazy

Background

Systemic sclerosis (SSc) is an autoimmune disease that affects skin, cardiovascular, pulmonary, and gastrointestinal affection. Autonomic dysfunction (AD) was observed early and even preceded fibrosis. Researchers are looking forward to evolving tools to detect subclinical AD. Aim of the work: This study aimed to evaluate parasympathetic dysfunction in SSc patients using R-R interval variation (RRIV) during both rest and deep breathing compared to control group, compare it with different tools used to assess AD and explore its relation to clinical characteristics of SSc patients. Patients and methods: This work included 40 subjects; 20 SSc cases and 20 healthy controls. All were subjected to RRIV at rest and at deep breathing, composite autonomic symptom score-31 (COMPASS-31) questionnaire for autonomic dysfunction symptoms, bedside autonomic function tests (active standing and Valsalva maneuver).Results: The mean age of patients was 35.36 ± 10.24 years, disease duration 54.12 ± 54.32 months and were 16 females and 4 males (F:M 4:1). There was a significantly higher RRIV at deep breathing in SSc (26.7 ± 23.3) compared to controls (11.4 ± 6.1)(p = 0.017). There was no significant difference in the results of bedside tests between SSc and control. The AD groups detected by bed side tests tended to have higher RRIV values at rest and during deep breathing compared to the non-AD groups. There was no correlation between RRIV measurements and COMPASS score. SSc patients with arthralgia had significantly lower RRIV at deep breathing (p = 0.042). Conclusion: The RRIV is a promising noninvasive and simple cardiovascular test for detection of early parasympathetic dysfunction in SSc patients.

背景：系统性硬化症（SSc）是一种影响皮肤、心血管、肺和胃肠道的自身免疫性疾病。自主神经功能障碍（AD）在纤维化早期甚至在纤维化发生之前就被观察到。研究人员期待着不断发展的检测亚临床AD的工具。工作目的：本研究旨在通过休息和深呼吸时R-R间隔变化（RRIV）与对照组比较SSc患者副交感神经功能障碍，并将其与不同的AD评估工具进行比较，探讨其与SSc患者临床特征的关系。患者和方法：本研究纳入40例受试者；20例SSc病例和20例健康对照。所有患者均在休息和深呼吸时接受RRIV，自主神经功能障碍症状综合评分-31 （COMPASS-31）问卷调查，床边自主神经功能测试（主动站立和Valsalva手法）。结果：患者平均年龄35.36±10.24岁，病程54.12±54.32个月，女性16例，男性4例（男女比例为4:1）。SSc患者深呼吸时的RRIV（26.7±23.3）明显高于对照组（11.4±6.1）（p = 0.017）。SSc组与对照组的床边试验结果无显著差异。与非AD组相比，通过床边试验检测到的AD组在休息和深呼吸时的RRIV值往往更高。RRIV测量值与COMPASS评分无相关性。伴有关节痛的SSc患者在深呼吸时RRIV明显降低（p = 0.042）。结论：RRIV是一种无创、简便的检测SSc患者早期副交感神经功能障碍的方法。

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引用次数: 0