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Validation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity Questionnaire for the Latin American Population. 拉丁美洲人群癌症治疗/妇科肿瘤组神经毒性问卷功能评估的验证
IF 1.9 Q3 Medicine Pub Date : 2022-09-10 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6533797
Ivana Leao Ribeiro, Luz Alejandra Lorca, Rodrigo Cuevas-Cid, Snehil Dixit, Nicolás Yáñez-Benavides, Francisco Ortega-Gonzalez

Background: Chemotherapy-induced peripheral neuropathy is a common adverse effect of chemotherapeutic treatment and is associated with decreased quality of life. The aim of this study was to evaluate the validity and reliability of the neurotoxicity subscale of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) for the Chilean population.

Methods: A cross-sectional study in which 101 participants with haematologic, colorectal, breast, gastric, gynaecological, and other types of cancer completed the FACT/GOG-Ntx. Content validity (n = 14 health professionals evaluated the subscale in four categories: test-retest reliability (n = 20 patients), dimensionality, internal consistency, and concurrent validity and discriminant validity. In all analyses, p < 0.05 was considered significant.

Results: There was an agreement among the evaluators for all categories of the subscale (Kendall's coefficient, W = 0.4, p < 0.01) and moderate to high intrarater reliability (intraclass correlation coefficient = 0.7-0.9). Of the 11 original items that make up the subscale, none was eliminated. The factor analysis generated four factors that represented 72.2% of the total variance. Cronbach's α was 0.8 for the 11 items. Women showed greater compromise in emotional well-being and neurotoxicity symptoms compared with men, and age was directly correlated with the questions 'I have difficulty hearing' (r = 0.2, p = 0.019) and 'I feel a noise or buzzing in my ears' (r = 0.2, p = 0.03).

Conclusion: The Chilean version of the FACT/GOG-Ntx neurotoxicity subscale is a valid and reliable scale for evaluating neurotoxicity symptoms in adult cancer survivors in Latin America. The scales also adequately distinguish between sex-based well-being among the afflicted population.

背景:化疗引起的周围神经病变是化疗常见的不良反应,与生活质量下降有关。本研究的目的是评估智利人群癌症治疗/妇科肿瘤组神经毒性功能评估(FACT/GOG-Ntx)神经毒性亚量表的有效性和可靠性。方法:在一项横断面研究中,101名患有血友病、结直肠癌、乳腺癌、胃癌、妇科和其他类型癌症的参与者完成了FACT/GOG-Ntx。内容效度(n = 14)从重测信度(n = 20)、维度、内部一致性、并发效度和区别效度四个方面对量表进行评估。在所有分析中,p < 0.05被认为是显著的。结果:评价者对量表各分类的肯德尔系数(Kendall's coefficient, W = 0.4, p < 0.01)均具有一致性,且具有中高的组内信度(组内相关系数= 0.7 ~ 0.9)。在构成该分量表的11个原始项目中,没有一个被删除。因子分析产生4个因子,占总方差的72.2%。11个条目的Cronbach’s α为0.8。与男性相比,女性在情绪健康和神经毒性症状方面表现出更大的妥协,年龄与“我听力有困难”(r = 0.2, p = 0.019)和“我感觉耳朵里有噪音或嗡嗡声”(r = 0.2, p = 0.03)的问题直接相关。结论:智利版FACT/GOG-Ntx神经毒性亚量表是评估拉丁美洲成年癌症幸存者神经毒性症状的有效可靠量表。这些量表还充分区分了患病人群中基于性别的幸福感。
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引用次数: 0
Effectiveness of Resistance Training on Fatigue in Patients Undergoing Cancer Treatment: A Meta-Analysis of Randomized Clinical Trials. 抗阻训练对癌症治疗患者疲劳的有效性:随机临床试验的荟萃分析。
IF 1.9 Q3 Medicine Pub Date : 2022-08-08 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9032534
Lily Berríos Contreras, Rodrigo Cuevas Cid, Luz Alejandra Lorca, Ivana Leão Ribeiro

Objective: To assess the effectiveness of the resistance training to improve fatigue levels in people with cancer who are enrolled in adjuvant and/or neoadjuvant treatment.

Methods: MEDLINE, Web of Science, Embase, SPORTDiscus, LILACS, CENTRAL, and CINAHL databases were searched from May to December 7, 2021. Randomized clinical trials (RCT) that evaluate the effects of resistance training on fatigue levels in people undergoing cancer treatment were included. The PEDro scale was considered to assess methodological quality of studies, and the evidence was summarized through the GRADE system. The standardized average differences, effect size, and inverse variance model for meta-analysis were calculated.

Results: Fifteen RCT for qualitative synthesis and thirteen for meta-analysis were selected. A moderate to high level of evidence of resistance training was identified to improve fatigue in people undergoing cancer treatment. Meta-analysis showed a significant reduction in fatigue (SMD = -0.31, CI 95% = -0.58, -0.12, P = 0.001) after 10 to 35 sessions of resistance training.

Conclusion: The 10 to 35 sessions of resistance training are effective in reducing fatigue level in cancer patients who are undergoing cancer treatment and have a moderate level of quality evidence.

目的:评估抗阻训练对参加辅助和/或新辅助治疗的癌症患者改善疲劳水平的有效性。方法:检索2021年5月至12月7日的MEDLINE、Web of Science、Embase、SPORTDiscus、LILACS、CENTRAL和CINAHL数据库。随机临床试验(RCT)评估抗阻训练对接受癌症治疗的人疲劳水平的影响。PEDro量表用于评估研究的方法学质量,并通过GRADE系统总结证据。计算标准化平均差异、效应大小和逆方差模型进行meta分析。结果:15个RCT用于定性综合,13个用于荟萃分析。有证据表明,中等到高水平的抗阻训练可以改善接受癌症治疗的人的疲劳。荟萃分析显示,在10 - 35次阻力训练后,疲劳显著减少(SMD = -0.31, CI 95% = -0.58, -0.12, P = 0.001)。结论:10 ~ 35次抗阻训练可有效降低癌症治疗患者的疲劳水平,具有中等质量水平的证据。
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引用次数: 0
Immunohistochemical Features of Breast Cancer Seen in Women in Kinshasa, Democratic Republic of the Congo: A Six-Year Retrospective Study. 刚果民主共和国金沙萨妇女乳腺癌的免疫组织化学特征:一项六年回顾性研究
IF 1.9 Q3 Medicine Pub Date : 2022-08-05 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8860947
Stanislas Maseb'a Mwang Sulu, Donatien Babaka Batalansi, Arnold Maseb Sul Sulu, Olivier Mukuku, Justin Esimo Mboloko, Désiré Kulimba Mashinda, Bienvenu Lebwaze Massamba, Antoine Wola Tshimpi

Introduction: The molecular classification of breast cancer (BC) based on gene expression and then protein profile has made it possible to distinguish different molecular subtypes. The objective of this study was to describe immunohistochemical features of BC infiltrating women at the Nganda Hospital Center in Kinshasa, Democratic Republic of the Congo (DRC).

Methods: A retrospective study from 2014 to 2019 involved 190 patients with invasive BC who were enrolled at the Nganda Hospital Center. The tumors were analyzed histologically and classified after an immunohistochemical study into subtypes: luminal A, luminal B, HER2-overexpressed, and triple-negative. A chi-square test was performed to assess the relationship between age, histological grade, and these subtypes.

Results: The luminal A subtype (44.74%) was the most common, followed by luminal B (40.53%), triple-negative (10.53%), and HER2-overexpressed (4.20%). The mean age of the patients at diagnosis was 48.27 years. Of all cases, 94.21% were ductal, 2.63% were mucinous, and 2.11% were lobular. They were classified as grade I in 68.82% of the cases, grade II in 28.42% of the cases, and grade III in 3.16% of the cases. There was a significant association between histological grade and breast cancer subtypes (p < 0.0001), but no correlation was found with age (p = 0.467).

Conclusion: In our BC patients, the luminal A was predominant, while HER2-overexpressed was the least found. A strong association was noted between histological grade and molecular subtypes. These results should allow for important clinical and policy implications for BC control in the DRC.

基于基因表达和蛋白谱的乳腺癌分子分类使得区分不同的分子亚型成为可能。本研究的目的是描述刚果民主共和国(DRC)金沙萨Nganda医院中心BC浸润妇女的免疫组织化学特征。方法:对2014年至2019年在nanda医院中心登记的190例浸润性BC患者进行回顾性研究。在免疫组织化学研究后,对肿瘤进行组织学分析和分类,分为管腔A型、管腔B型、her2过表达型和三阴性。采用卡方检验来评估年龄、组织学分级和这些亚型之间的关系。结果:以腔内A亚型(44.74%)最为常见,其次为腔内B亚型(40.53%)、三阴性(10.53%)和her2过表达(4.20%)。确诊时患者平均年龄48.27岁。94.21%为导管,2.63%为粘液,2.11%为小叶。其中ⅰ级占68.82%,ⅱ级占28.42%,ⅲ级占3.16%。组织学分级与乳腺癌亚型有显著相关性(p < 0.0001),与年龄无相关性(p = 0.467)。结论:在我们的BC患者中,管腔A是主要的,而her2过表达是最少的。组织学分级和分子亚型之间存在很强的相关性。这些结果对刚果民主共和国的BC控制具有重要的临床和政策意义。
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引用次数: 1
Breast Cancer in Adolescents and Young Adults Less Than 40 Years of Age in Nigeria: A Retrospective Analysis. 尼日利亚 40 岁以下青少年和年轻人中的乳腺癌:回顾性分析
IF 1.6 Q4 ONCOLOGY Pub Date : 2022-07-29 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9943247
Atara Ntekim, Mojisola Oluwasanu, Oluwaponmile Odukoya

Background: Breast cancer among adolescents and young adult (AYA) females aged 15-39 years is associated with different patterns of aggressiveness, as well as psychosocial and economic issues. At present, the burden of breast cancer among this age group is unknown in Nigeria. There is a need to determine the proportion of AYA with breast cancer in Nigeria. This will inform the development of breast cancer care programs appropriate for this age group.

Objective: The objective of this study was to highlight the burden of breast cancer with an emphasis on AYAs in Nigeria and its implications.

Methods: A retrospective review of data from cancer registries in Nigeria between 2009 and 2016 was carried out.

Result: s. Among AYA females in Nigeria, breast cancer was by far the most common cancer, constituting 50% of all cancers and 51% (2798 of 5469) of all breast cancer cases. IA third (30.8%) of breast cancer cases in all centers studied were AYAs.

Conclusion: The high proportion of AYA with breast cancer is an important feature suggesting that urgent actions are required to ensure early detection and improve breast cancer care among this age group.

背景:15-39 岁青少年和年轻成人(AYA)女性乳腺癌与不同的侵袭模式以及社会心理和经济问题有关。目前,尼日利亚对这一年龄组的乳腺癌负担尚不清楚。有必要确定尼日利亚青壮年乳腺癌患者的比例。这将为制定适合这一年龄组的乳腺癌护理计划提供依据:本研究的目的是强调乳腺癌的负担,重点是尼日利亚的青壮年乳腺癌患者及其影响:结果:S. 在尼日利亚的 AYA 女性中,乳腺癌是迄今为止最常见的癌症,占所有癌症的 50%,占所有乳腺癌病例的 51%(5469 例中的 2798 例)。在所研究的所有中心中,三分之一(30.8%)的乳腺癌病例为青壮年:结论:青少年乳腺癌患者比例高是一个重要特征,表明需要采取紧急行动,确保及早发现并改善这一年龄组的乳腺癌护理。
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引用次数: 0
In Vitro Growth Inhibition, Caspase-Dependent Apoptosis, and S and G2/M Phase Arrest in Breast Cancer Cells Induced by Fluorine-Incorporated Gold I Compound, Ph3PAu[SC(OMe)=NC6H4F-3]. 含氟金I化合物Ph3PAu诱导乳腺癌细胞体外生长抑制、caspase依赖性凋亡及S和G2/M期阻滞[SC(OMe)=NC6H4F-3]。
IF 1.9 Q3 Medicine Pub Date : 2022-07-21 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7168210
Richard Ming Chuan Yu, Gayathri Thevi Selvarajah, Geok Chin Tan, Yoke-Kqueen Cheah

Gold-based anticancer compounds have been attracting increasing research interest due to their ability to kill cancer cells resistant to platinum-based compounds. Gold I- and gold III-based complexes have shown satisfactory anticancer activities. In this study, two new fluorine-incorporated gold (I) compounds such as Ph3PAu[SC(OMe)=NC6H4F-3] and DPPFeAu2[(SC(OMe)=NC6H4F-3)]2 were evaluated for their in vitro activities against human breast cancer cell lines, primary breast cancer cells, and breast cancer stem cells (parental breast cancer stem cells, BCSC-P, and breast cancer stem cells, BCSC). Assays for growth inhibition and cytotoxicity, including real-time cell analysis, were carried out to screen effective antibreast cancer compounds. In addition, further in vitro assays such as apoptosis, caspase 3/7 activity, and cell cycle analysis were performed to observe the action and mechanism of killing breast cancer cells by the selected gold I compound, Ph3PAu[SC(OMe)=NC6H4F-3]. The gold (I) compound, Ph3PAu[SC(OMe)=NC6H4F-3], showed low toxicity to H9c2 normal cells and significant growth inhibition in MDA-MB-231 and MCF-7 cells, primary breast cancer cells, and breast cancer stem cells (BCSC-P and BCSC). The IC50 doses of the gold (I) compound Ph3PAu[SC(OMe)=NC6H4F-3] against the breast cancer cell lines MDA-MB-231 and MCF-7 were approximately 6-fold lower than that of cisplatin (cis-diamineplatinum (II) dichloride, CDDP). Moreover, the compound Ph3PAu[SC(OMe)=NC6H4F-3] induced caspase 3/7-dependent apoptosis and cell cycle arrest at S and G2/M phases. Ph3PAu[SC(OMe)=NC6H4F-3], a gold (I) compound incorporated with fluorine, is a potential candidate for the treatment of breast cancer.

金基抗癌化合物由于能够杀死抵抗铂基化合物的癌细胞而引起了越来越多的研究兴趣。金I和金iii基配合物显示出令人满意的抗癌活性。本研究对两种新型含氟金(I)化合物Ph3PAu[SC(OMe)=NC6H4F-3]和DPPFeAu2[(SC(OMe)=NC6H4F-3)]2对人乳腺癌细胞系、原发性乳腺癌细胞和乳腺癌干细胞(亲代乳腺癌干细胞BCSC- p和乳腺癌干细胞BCSC)的体外活性进行了评价。进行生长抑制和细胞毒性试验,包括实时细胞分析,以筛选有效的抗乳腺癌化合物。此外,通过细胞凋亡、caspase 3/7活性、细胞周期分析等体外实验,观察筛选出的金I化合物Ph3PAu[SC(OMe)=NC6H4F-3]杀伤乳腺癌细胞的作用及机制。金(I)化合物Ph3PAu[SC(OMe)=NC6H4F-3]对H9c2正常细胞具有低毒性,对MDA-MB-231和MCF-7细胞、原发性乳腺癌细胞和乳腺癌干细胞(BCSC- p和BCSC)具有显著的生长抑制作用。金(I)化合物Ph3PAu[SC(OMe)=NC6H4F-3]对乳腺癌细胞株MDA-MB-231和MCF-7的IC50剂量比顺铂(顺二胺铂(II)二氯化,CDDP)低约6倍。此外,化合物Ph3PAu[SC(OMe)=NC6H4F-3]在S期和G2/M期诱导caspase 3/7依赖性细胞凋亡和细胞周期阻滞。Ph3PAu[SC(OMe)=NC6H4F-3]是一种与氟结合的金(I)化合物,是治疗乳腺癌的潜在候选物。
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引用次数: 1
Profile of Male Breast Cancer in Makkah Region of Saudi Arabia: A 4-Year Retrospective Analysis of Radiology and Histopathology. 沙特阿拉伯麦加地区男性乳腺癌概况:4年放射学和组织病理学回顾性分析。
IF 1.9 Q3 Medicine Pub Date : 2022-06-22 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8831011
Muhammad Saeed, Bothaina Mohammed Abdulshakour, Najwa Abdalkabeer A Bantan, Afnan Hisham Falemban, Munir Abdulla, Ehab M Melibary, Ahmad H Mufti, Mohiuddin M Taher

Background: Mammography is a method widely used for the diagnosis of breast disorders in women and may help detect breast cancer in its early stages. Male breast cancer often remains undiagnosed or is poorly controlled until serious complications arise; therefore, the use of screening methods is needed to help with early diagnosis.

Methods: From a total of 1,667 registered mammography cases screened, 17 male breast disease cases were included in this study. Mammography and ultrasound data were analyzed by Statistical Package of Social Sciences v.22 (SPSS). Diagnosis was made following biopsy in suspicious cases, and histopathological and immunological findings of all such patients were obtained for final diagnosis.

Results: The mean age of the patients was 35 years (range, 14-70 years); 17.6% of the cases were aged 37 yrs, and 2 cases were aged 51 and 52 yrs. Of the 17 cases, 11 had breast lesions, and skin thickening was observed in only 1 case. The different patterns of lesions detected were asymmetry of the parenchyma, mastitis, and hamartoma (n = 1 each), malignant lesions (n = 2), and gynecomastia (n = 6). According to the BI-RADS categorization, 8 cases were benign, one case was probably benign, and 2 cases were likely malignant. In the 2 cases with malignant lesions, pathological diagnosis was made after hematoxylin and eosin and immunocytochemistry examination as invasive ductal carcinoma (IDC) of no special type (NST), grade II and grade III.

Conclusions: Most breast lesions in this study population were benign, while IDC was the most common malignancy encountered. Mammography is currently the most accurate and cost-effective method for detecting breast lesions. The findings of our study may help increase awareness of male breast cancer and encourage Saudi men at risk to perform self-breast exam and undergo routine breast screening.

背景:乳房x光检查是一种广泛用于女性乳腺疾病诊断的方法,可能有助于在早期发现乳腺癌。男性乳腺癌在出现严重并发症之前往往无法确诊或控制不良;因此,需要使用筛查方法来帮助早期诊断。方法:从1,667例登记的乳房x光检查病例中筛选出17例男性乳腺疾病病例。乳房x光检查和超声波数据使用社会科学统计软件包v.22进行分析(SPSS)。可疑病例活检后诊断,并获得所有此类患者的组织病理学和免疫学结果以最终诊断。结果:患者平均年龄35岁(14 ~ 70岁);37岁占17.6%,51岁和52岁占2例。17例中11例有乳腺病变,仅有1例皮肤增厚。不同类型病变分别为实质不对称、乳腺炎、错构瘤各1例,恶性病变2例,男性乳房发育6例。根据BI-RADS分类,良性8例,可能良性1例,可能恶性2例。2例恶性病变,经苏木精、伊红及免疫细胞化学检查病理诊断为浸润性导管癌(invasive ductal carcinoma, IDC),无特殊类型(NST), II级和III级。结论:本研究人群中大多数乳腺病变为良性,而IDC是最常见的恶性肿瘤。乳房x光检查是目前检测乳腺病变最准确、最经济的方法。我们的研究结果可能有助于提高对男性乳腺癌的认识,并鼓励有风险的沙特男性进行自我乳房检查和常规乳房筛查。
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引用次数: 0
The Effect of a Combined Modified Pectoral and Stellate Ganglion Block on Stress and Inflammatory Response in Patients Undergoing Modified Radical Mastectomy. 改良胸廓和星状神经节联合阻滞对改良根治性乳房切除术患者应激和炎症反应的影响
IF 1.6 Q4 ONCOLOGY Pub Date : 2022-06-06 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3359130
Jun Geng, Jing Wang, Yaowen Zhang, Wenxiang Song, Junjia Zhu, Jianqing Chen, Zhen Wu

Background and aims: Regional anaesthesia reports to attenuate stress and inflammatory responses associated with surgical resection; however, the effectiveness of combined nerve blocks is less often investigated. We evaluated whether a combination of a pectoral nerve block (PNB) and stellate ganglion block (SGB) is more effective than a PNB alone in reducing these responses in women undergoing modified radical mastectomy (MRM).

Methods: This is a prospective randomized controlled trial. Fifty patients with breast cancer were randomly allocated to receive an ultrasound-guided PNB (n = 25, PNB only group) or ultrasound-guided PNB combined with SGB (n = 25, combined blockade group). The primary outcome was perioperative plasma level of interleukin- (IL-) 6. Secondary outcomes included perioperative plasma levels of cortisol, glucose, IL-8, and tumour necrosis factor- (TNF-) α, pain scores, haemodynamic variables, sleep quality, and complications postsurgery.

Results: The combined blockade group exhibited significantly lower IL-6 and TNF-α levels 24 h postsurgery. Cortisol levels were significantly lower in the combined blockade group at the end of the surgery. Glucose levels at the time of incision were lower in the combined blockade group. Pain scores up to 12 h postsurgery were significantly lower in the combined blockade group, which also exhibited better perioperative haemodynamic stability. Patients in the combined blockade group reported better sleep quality on the night of surgery.

Conclusion: In patients undergoing MRM, PNB combined with SGB block effectively blunted perioperative inflammatory response than PNB alone. A combined block approach can also alleviate stress response and postoperative acute pain with stable perioperative haemodynamics and better postoperative sleep quality.

背景和目的:据报道,区域麻醉可减轻与手术切除相关的应激和炎症反应;然而,对联合神经阻滞的效果却较少进行研究。我们评估了胸神经阻滞(PNB)和星状神经节阻滞(SGB)联合使用是否比单独使用胸神经阻滞更能有效减轻接受改良根治性乳房切除术(MRM)的妇女的这些反应:这是一项前瞻性随机对照试验。方法:这是一项前瞻性随机对照试验,50 名乳腺癌患者被随机分配接受超声引导下的 PNB(n = 25,仅 PNB 组)或超声引导下的 PNB 联合 SGB(n = 25,联合阻断组)。主要结果是围手术期血浆白细胞介素(IL-)6水平。次要结果包括围手术期皮质醇、葡萄糖、IL-8 和肿瘤坏死因子 (TNF-) α 的血浆水平、疼痛评分、血流动力学变量、睡眠质量和术后并发症:结果:联合阻断组术后 24 小时的 IL-6 和 TNF-α 水平明显降低。手术结束时,联合阻断组的皮质醇水平明显降低。联合阻断组在切口时的葡萄糖水平较低。联合阻断组术后 12 小时内的疼痛评分明显降低,围手术期血流动力学稳定性也更好。联合阻滞组患者在手术当晚的睡眠质量更好:结论:在接受 MRM 的患者中,PNB 联合 SGB 阻滞比单用 PNB 更能有效减轻围术期炎症反应。结论:在接受 MRM 的患者中,PNB 联合 SGB 阻滞比单用 PNB 能有效减轻围术期炎症反应,联合阻滞方法还能减轻应激反应和术后急性疼痛,并能稳定围术期血流动力学和提高术后睡眠质量。
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引用次数: 0
The Effect of Educational Intervention on Knowledge, Attitude, and Practice of Women towards Breast Cancer Screening 教育干预对女性乳腺癌筛查知识、态度和行为的影响
IF 1.9 Q3 Medicine Pub Date : 2022-05-26 DOI: 10.1155/2022/5697739
T. Rakhshani, Maryam Dada, Seyyed Mansour Kashfi, A. Kamyab, A. K. Jeihooni
Background Early identification of breast cancer may result in earlier treatment and a lower mortality rate. This fact has resulted in the development of screening programs to detect breast cancer in its early stages; thus, the current study sought to investigate the influence of educational intervention on knowledge, attitude, and practice about breast cancer screening in Izeh, Khozestan Province, Iran. Materials and Methods This experiment was carried out on the women of Izeh city in 2019. This study included 120 women who were randomized into the experimental and control groups at random (60 in the experimental and 60 in the control groups). Before and two months after the intervention, data were collected using a researcher-created questionnaire by the control and education groups. The intervention program for the intervention group included eight educational sessions over the course of two months. The SPSS 20 statistical program was used to examine the data, as well as the paired t-test, independent t-test, and Chi-square. Results There was no significant difference between the experimental and control groups' mean scores of knowledge, attitude, and practice prior to the educational intervention, but a significant difference was observed after the intervention, with the experimental group obtaining significantly higher mean scores of knowledge, attitude, and practice (P = 0.05). Conclusion In the present study, the educational intervention on the knowledge, attitude, and practice towards breast cancer screening led to the increased scores of the experimental group compared to control group.
背景乳腺癌的早期发现可能导致早期治疗和较低的死亡率。这一事实导致了在早期阶段检测乳腺癌的筛查项目的发展;因此,本研究旨在调查教育干预对伊朗Khozestan省Izeh地区乳腺癌筛查的知识、态度和实践的影响。材料与方法本实验于2019年以伊泽市女性为研究对象。本研究包括120名女性,她们随机分为实验组和对照组(实验组60名,对照组60名)。在干预前和干预后两个月,控制组和教育组使用研究人员设计的问卷收集数据。干预组的干预计划包括八个为期两个月的教育课程。采用SPSS 20统计程序对数据进行检验,并采用配对t检验、独立t检验和卡方检验。结果实验组与对照组在教育干预前的知识、态度、实践平均得分差异无统计学意义,干预后差异有统计学意义,实验组的知识、态度、实践平均得分显著高于对照组(P = 0.05)。结论在本研究中,通过对乳腺癌筛查知识、态度和行为的教育干预,实验组的得分明显高于对照组。
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引用次数: 2
Evolution of Frozen Section in Carcinoma Breast: Systematic Review 乳腺癌冷冻切片的演变:系统回顾
IF 1.9 Q3 Medicine Pub Date : 2022-05-23 DOI: 10.1155/2022/4958580
M. Rana, A. P. S. Rana, Uttam Sharma, T. S. Barwal, Aklank Jain
Background The frozen section (FS) has been a good technique in surgical management of breast lesions since many years. But complete agreement and cooperation have not been achieved everywhere among surgeons and pathologists especially in the developing countries. FS undergoes continuous criticism due to various shortcomings but continued to be evaluated especially in developing countries. Objectives This review was conducted to synthesize information on the use of frozen section in carcinoma breast. Data Sources. The MEDLINE database for frozen section since its origin and its implication in recent breast surgery techniques was studied. Study Eligibility Criteria. Sixty-five articles were reviewed with complete analysis on FS in both benign and malignant breast lesions. Study Appraisal and Synthesis Methods. The analysis of frozen section was done as a diagnostic tool in breast lesions, margin status in breast conservative surgery in carcinoma breast, and sentinel lymph node and use of immunohistochemistry for sentinel lymph node FS. Results It was analysed that the FS gives accurate results in margin status analysis, decreasing rerecurrence. Conclusion The accuracy of FSA, low recurrence rate, avoidance of reoperation, and good cosmesis are the key points of its use in breast conservative surgery. Its use in sentinel lymph node biopsy (SLNB) is equivocal. However, application of immunohistochemistry on frozen section of SLNB is an evolving trend in today's era.
背景冷冻切片(FS)多年来一直是乳腺病变外科治疗的一种良好技术。但在外科医生和病理学家之间,特别是在发展中国家,并没有完全达成一致和合作。由于各种缺点,金融系统不断受到批评,但继续受到评价,特别是在发展中国家。目的对冷冻切片在乳腺癌中的应用进行综述。数据源。研究了MEDLINE冷冻切片数据库的起源及其在近期乳房手术技术中的意义。研究资格标准。本文回顾了65篇关于FS在乳腺良恶性病变中的完整分析。研究评价与综合方法。分析冷冻切片作为乳腺病变的诊断工具、乳腺癌保守手术的边缘状态、前哨淋巴结和前哨淋巴结FS的免疫组织化学应用。结果经分析,FS对切缘状态分析结果准确,减少了复发率。结论FSA准确、复发率低、避免再手术、美观性好是其在乳房保守手术中应用的关键。它在前哨淋巴结活检(SLNB)中的应用尚不明确。然而,免疫组织化学在SLNB冷冻切片上的应用是当今时代的发展趋势。
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引用次数: 0
The Patient Health Engagement Model in Cancer Management: Effect of Physical Activity, Distress Management, and Social Support Intervention to Improve the Quality of Life in Breast Cancer Patients 癌症管理中的患者健康参与模型:体育活动、痛苦管理和社会支持干预对改善乳腺癌患者生活质量的影响
IF 1.9 Q3 Medicine Pub Date : 2022-04-30 DOI: 10.1155/2022/1944852
M. Changizi, L. Ghahremani, N. Ahmadloo, M. Kaveh
Background Providing better care and encouraging behaviors promoting health are effective measures to manage breast cancer patients. The present research was conducted to carry out an intervention based on the PHE model to promote physical activity, distress management, social support, and quality of life in breast cancer patients. Methods This randomized control trial study was conducted on 123 women with breast cancer and their caregivers (group 1 = 61 and group 2 = 62). Subjects entered the study from the oncology ward of a specialized clinic in Shiraz, Iran. The education was done through clips, pamphlets, and lectures in 8 sessions with a duration of 15 to 25 minutes. A posttest was carried out in the both groups in 2 times (the end and 3 months) after intervention. The SPSS25 software was used to analyze the data. Results The mean and SD of age of group 1 were (45.77 ± 8.84) and control group 2 (45.58 ± 77.64). The fiding showed a significant difference between the mean scores of distress management, social support, physical activity, and cancer self-efficacy in group 1 vs. group 2 after intervention (P < 0.001). Also, the educational intervention improved quality of life (P = 0.003). Conclusion Intervention program based on the PHE model may facilitate the cognitive, emotional, and behavioral processes in breast cancer patient. Thus, it appears that the PHE model might promote patients' quality of life.
背景提供更好的护理和鼓励促进健康的行为是管理乳腺癌患者的有效措施。本研究旨在开展基于PHE模型的干预,以促进乳腺癌患者的身体活动、痛苦管理、社会支持和生活质量。方法对123例乳腺癌患者及其护理人员(组1 = 61,组2 = 62)进行随机对照研究。受试者从伊朗设拉子一家专科诊所的肿瘤病房进入研究。教育是通过剪辑、小册子和讲座进行的,分8次,每次15到25分钟。两组分别于干预后2次(结束和3个月)进行后测。采用SPSS25软件对数据进行分析。结果1组患者的平均年龄为(45.77±8.84)岁,2组患者的平均年龄为(45.58±77.64)岁。研究结果显示,干预后1组与2组患者在痛苦管理、社会支持、身体活动和癌症自我效能感的平均得分差异有统计学意义(P < 0.001)。此外,教育干预改善了生活质量(P = 0.003)。结论基于PHE模型的干预方案可促进乳腺癌患者的认知、情绪和行为过程。因此,PHE模式似乎可以提高患者的生活质量。
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引用次数: 1
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International Journal of Breast Cancer
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