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A young boy with severe pulmonary-renal syndrome: Will you suspect IgA nephropathy? 一个患有严重肺肾综合征的小男孩:你会怀疑IgA肾病吗?
IF 0.9 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.4103/2452-2473.357334
Tejinderpal Singh Grewal, Dipesh Soni, Ritambhra Nada, Navneet Sharma, Ashok Kumar Pannu

IgA nephropathy is a renal-limited form of systemic vasculitis, and pulmonary manifestations are uncommon. An initial presentation with severe diffuse alveolar hemorrhage (DAH) or pulmonary-renal syndrome is rare and only confined to a few case reports. Herein, we present a young male admitted with acute-onset dyspnea, hemoptysis, and rapidly progressive renal failure. With an initial diagnosis of an immune-mediated pulmonary-renal syndrome, he was treated with high-dose corticosteroids and therapeutic plasmapheresis along with intensive organ support (including hemodialysis, red cell transfusion, and high-flow oxygen). After a detailed laboratory evaluation and kidney biopsy, IgA nephropathy was diagnosed. The patient continued to worsen with persistent DAH and died. IgA nephropathy-associated severe DAH or pulmonary-renal syndrome is rare but increasingly recognized. The condition is difficult to diagnose early and has no proven disease-targeted therapy.

IgA肾病是一种肾脏受限的全身性血管炎,肺部表现不常见。最初表现为严重弥漫性肺泡出血(DAH)或肺肾综合征是罕见的,仅局限于少数病例报告。在此,我们报告一位年轻男性因急性呼吸困难、咯血和快速进行性肾功能衰竭而入院。由于初步诊断为免疫介导的肺肾综合征,患者接受了大剂量皮质类固醇和治疗性血浆置换治疗,并辅以强化器官支持(包括血液透析、红细胞输血和高流量氧气)。经过详细的实验室评估和肾活检,诊断为IgA肾病。患者病情持续恶化,并发持续性DAH,最终死亡。IgA肾病相关的严重DAH或肺肾综合征是罕见的,但越来越多的认识。这种情况很难早期诊断,也没有明确的疾病靶向治疗方法。
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引用次数: 0
Prehospital management of earthquake crush injuries: A collective review 地震挤压伤的院前处理:综述
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.4103/tjem.tjem_201_23
FikriM Abu-Zidan, Kamal Idris, ArifAlper Cevik
Earthquakes are natural disasters which can destroy the rural and urban infrastructure causing a high toll of injuries and death without advanced notice. We aim to review the prehospital medical management of earthquake crush injuries in the field. PubMed was searched using general terms including rhabdomyolysis, crush injury, and earthquake in English language without time restriction. Selected articles were critically evaluated by three experts in disaster medicine, emergency medicine, and critical care. The medical response to earthquakes includes: (1) search and rescue; (2) triage and initial stabilization; (3) definitive care; and (4) evacuation. Long-term, continuous pressure on muscles causes crush injury. Ischemia–reperfusion injury following the relieving of muscle compression may cause metabolic changes and rhabdomyolysis depending on the time of extrication. Sodium and water enter the cell causing cell swelling and hypovolemia, while potassium and myoglobin are released into the circulation. This may cause sudden cardiac arrest, acute extremity compartment syndrome, and acute kidney injury. Recognizing these conditions and treating them timely and properly in the field will save many patients. Majority of emergency physicians who have worked in the field of the recent Kahramanmaraş 2023, Turkey, earthquakes, have acknowledged their lack of knowledge and experience in managing earthquake crush injuries. We hope that this collective review will cover the essential knowledge needed for properly managing seriously crushed injured patients in the earthquake field.
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引用次数: 0
Poor adherence to the recommended pulmonary embolism diagnostic pathway in the emergency department: A retrospective cohort study. 急诊科对推荐的肺栓塞诊断途径的依从性差:一项回顾性队列研究。
IF 0.9 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.4103/2452-2473.366486
Alia M Hadid, Ala Jalabi, Mahmoud Anka, Arif Alper Cevik

Objectives: Pulmonary embolus (PE) is a form of venous thromboembolism associated with increased morbidity and mortality if not diagnosed and treated early. Variations in clinical presentation make the diagnosis challenging. The gold standard for diagnosing PE is a computed tomography pulmonary angiogram (CTPA). Physicians show a low threshold for over-investigating PE. The evaluation of patients with suspected PE should be efficient, including but not limited to the use of risk stratification methods. This study aims to assess the adherence to the recommended diagnostic pathways of ordering CTPAs in patients with suspected PE.

Methods: This retrospective cohort study included patients above 18 years of age who received a CTPA for a suspected PE in the emergency department (ED) of a hospital between 2015 and 2019. Patient demographic data, chief complaint, variables of the Wells and pulmonary emboli rule-out criteria scores, pregnancy status, investigations, and the patient's final PE diagnosis were extracted from the hospital electronic medical records. Diagnostic pathways that took place were compared to the internationally recommended pathway.

Results: Four hundred and eighty-six patients were included in this study. The mean age was 51.01 (±19.5) years, and 377 (69.3%) patients were female. The recommended PE diagnostic pathway to order CTPA was incorrectly followed in 288 patients (59.3%). Seventy-five (15.4%) patients received an unnecessary CTPA. D-dimer test was ordered unnecessarily in 144 patients (29.6%). The overall prevalence of PE in our population was 9.47% (n: 46). Out of the 75 unnecessarily ordered CTPAs, 2 (2.7%) showed PE, while CTPAs ordered using the correct pathway showed 31 (10.9%) PEs.

Conclusion: Our study revealed that approximately two-thirds of all CTPA requests did not adhere to the recommended PE clinical decision pathway. There was a significant improper and unnecessary utilization of CTPA imaging and D-dimer testing. Improvements seem imperative to enhance physicians' clinical approach to PE diagnosis.

目的:肺栓塞(PE)是一种静脉血栓栓塞,如果不及早诊断和治疗,其发病率和死亡率会增加。临床表现的变化使诊断具有挑战性。诊断PE的金标准是ct肺血管造影(CTPA)。医生显示过度调查PE的门槛很低。对疑似PE患者的评估应该是有效的,包括但不限于使用风险分层方法。本研究旨在评估对疑似PE患者订购CTPAs的推荐诊断途径的依从性。方法:本回顾性队列研究纳入了2015年至2019年期间在某医院急诊科(ED)因疑似PE接受CTPA治疗的18岁以上患者。从医院电子病历中提取患者人口统计数据、主诉、Wells变量和肺栓塞排除标准评分、妊娠状况、调查和患者最终PE诊断。将发生的诊断途径与国际推荐的途径进行比较。结果:共纳入486例患者。平均年龄51.01(±19.5)岁,女性377例(69.3%)。288例(59.3%)患者错误地遵循了推荐的PE诊断途径来订购CTPA。75例(15.4%)患者接受了不必要的CTPA。144例(29.6%)患者被要求进行不必要的d -二聚体检测。我们人群中PE的总患病率为9.47% (n: 46)。在75个不必要的ctpa中,2个(2.7%)显示PE,而使用正确途径订购的ctpa显示31个(10.9%)PE。结论:我们的研究显示,大约三分之二的CTPA请求没有遵循推荐的PE临床决策途径。CTPA成像和d -二聚体检测存在明显的不当和不必要的使用。改进似乎势在必行,以提高医生的临床方法PE诊断。
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引用次数: 0
Accuracy of airway ultrasound parameters to predict difficult airway using the LEMON criteria as a reference: A cross-sectional diagnostic accuracy study. 以LEMON为参考的气道超声参数预测困难气道的准确性:一项横断面诊断准确性研究。
IF 0.9 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.4103/2452-2473.366484
Mehran Sotoodehnia, Najmeh Abbasi, Razman Arabzadeh Bahri, Atefeh Abdollahi, Alireza Baratloo

Objectives: Ultrasound (US) airway indexes were frequently compared with other scoring systems such as Mallampati score and Cormack - Lehane classification system, but to the best of our knowledge never with LEMON. Here, in this study, we evaluated the accuracy of some recommended airway US parameters in terms of screening difficult airway using the LEMON criteria as a reference.

Methods: This was a cross-sectional diagnostic accuracy study in which people with at least 18 years old coming to the emergency departments for any reason who had consent for participation, were enrolled with the simple random sampling method. Hyo-mental distance (HMD), skin to epiglottis distance (EP), and peri-epiglottic space to epiglottis to vocal cord ratio (PEP/E. VC) were the US indexes that were calculated in all participants. Using a preprepared checklist, measured US parameters were recorded. For each participant, the LEMON score variables were also assessed and recorded, and the cutoff point for considering as a difficult airway case, based on LEMON score, was 2. Demographic characteristics of the participants were also registered.

Results: A total of 299 cases with a mean age of 41.1 years (95% confidence interval [CI]: 39.3-42.9), were participated. Based on LEMON score ≥2, 20 participants (6.7%) were categorized in difficult airway group. Comparison of the PEP/E. VC (P = 0.007) and EP distance (P = 0.049) of the participants based on LEMON score showed a statistically significant difference; but comparison of the means of HMD in the two groups was not statistically significant (P = 0.144). The median of EP of the participants was 7.70 mm (interquartile range [IQR]: 6.70-9.40). The best cutoff point of EP distance for evaluating a difficult airway was 12.27 mm and more with the sensitivity of 35% and the specificity of 86.96% (accuracy = 0.614; 95% CI: 0.492-0.736). The median of PEP/E. VC was 1.01(IQR: 0.79-1.23). The best cutoff point of PEP/E. VC for evaluating a difficult airway was 0.88 and less with the sensitivity of 70% and the specificity of 67.38% (accuracy = 0.701; 95% CI: 0.583-0.818).

Conclusion: As per our results, PEP/E. VC and EP distance measured with sonography can be used in distinguishing the difficult airway, using the LEMON criteria as the reference. However, further studies are needed to use PEP/E. VC and EP distance as a part of reliable indexes.

目的:超声(US)气道指标经常与其他评分系统(如Mallampati评分和Cormack - Lehane评分系统)进行比较,但据我们所知从未与LEMON进行过比较。在本研究中,我们以LEMON标准为参考,评估了一些推荐的气道US参数在筛选困难气道方面的准确性。方法:这是一项横断面诊断准确性研究,研究对象为18岁以上因任何原因前来急诊科就诊且同意参与的患者,采用简单随机抽样方法。舌心距离(HMD)、皮肤到会厌距离(EP)、会厌周围空间到会厌与声带的比值(PEP/E)。VC)是在所有参与者中计算的美国指数。使用预先准备的检查表,记录测量的美国参数。对于每个参与者,还评估和记录了LEMON评分变量,并根据LEMON评分考虑为气道困难病例的截止点为2。参加者的人口统计特征亦已登记。结果:共纳入299例患者,平均年龄41.1岁(95%可信区间[CI]: 39.3-42.9)。根据LEMON评分≥2分,将20例(6.7%)患者分为气道困难组。PEP/E的比较。受试者基于LEMON评分的VC (P = 0.007)和EP距离(P = 0.049)差异有统计学意义;两组HMD均值比较无统计学意义(P = 0.144)。受试者的EP中位数为7.70 mm(四分位间距[IQR]: 6.70-9.40)。评估困难气道的最佳EP距离截断点为12.27 mm及以上,敏感性为35%,特异性为86.96%(准确性= 0.614;95% ci: 0.492-0.736)。PEP/E的中位数。VC为1.01(IQR: 0.79 ~ 1.23)。PEP/E的最佳截止点。评估气道困难的VC值为0.88或更低,敏感性为70%,特异性为67.38%(准确性= 0.701;95% ci: 0.583-0.818)。结论:根据我们的结果,PEP/E。超声测量的VC和EP距离可用于区分困难气道,以LEMON标准为参考。但是,PEP/E的使用还需要进一步的研究。VC和EP距离作为部分可靠指标。
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引用次数: 1
Receiver operating characteristic curve analysis in diagnostic accuracy studies: A guide to interpreting the area under the curve value 诊断准确性研究中的受者工作特征曲线分析:曲线值下面积解释指南
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.4103/tjem.tjem_182_23
ŞerefKerem Çorbacıoğlu, Gökhan Aksel
This review article provides a concise guide to interpreting receiver operating characteristic (ROC) curves and area under the curve (AUC) values in diagnostic accuracy studies. ROC analysis is a powerful tool for assessing the diagnostic performance of index tests, which are tests that are used to diagnose a disease or condition. The AUC value is a summary metric of the ROC curve that reflects the test’s ability to distinguish between diseased and nondiseased individuals. AUC values range from 0.5 to 1.0, with a value of 0.5 indicating that the test is no better than chance at distinguishing between diseased and nondiseased individuals. A value of 1.0 indicates perfect discrimination. AUC values above 0.80 are generally consideredclinically useful, while values below 0.80 are considered of limited clinical utility. When interpreting AUC values, it is important to consider the 95% confidence interval. The confidence interval reflects the uncertainty around the AUC value. A narrow confidence interval indicates that the AUC value is likely accurate, while a wide confidence interval indicates that the AUC value is less reliable. ROC analysis can also be used to identify the optimal cutoff value for an index test. The optimal cutoff value is the value that maximizes the test’s sensitivity and specificity. The Youden index can be used to identify the optimal cutoff value. This review article provides a concise guide to interpreting ROC curves and AUC values in diagnostic accuracy studies. By understanding these metrics, clinicians can make informed decisions about the use of index tests in clinical practice.
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引用次数: 0
Erratum: Current status of acute ischemic stroke management in Iran: Findings from a single-center study. 勘误:伊朗急性缺血性卒中管理的现状:来自一项单中心研究的结果。
IF 0.9 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.4103/2452-2473.366481

[This corrects the article on p. 213 in vol. 4.].

[这是对第四卷第213页的文章的更正]。
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引用次数: 0
Self-ingestion of vasmol dye. 自身摄入血管酚染料。
IF 0.9 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.4103/2452-2473.357330
Jaspreet Kaur, Aman Garg, Baldeep Kaur

Vasmol, a commonly used hair dye, is becoming apparent as one of the major causes of suicidal poisoning in India. The toxic components in the dye include paraphenylenediamine, sodium ethylenediaminetetraacetic acid, resorcinol, and propylene glycol. Acute poisoning by consumption of dye leads to characteristic angioedema of the cervicofacial region along with multiorgan dysfunction. Early intervention with tracheostomy can be lifesaving in such cases and helps in preventing the morbidity and mortality associated with it.

Vasmol,一种常用的染发剂,正在成为印度自杀中毒的主要原因之一。染料中的有毒成分包括对苯二胺、乙二胺四乙酸钠、间苯二酚和丙二醇。因食用染料引起的急性中毒可导致颈面区特征性血管性水肿并伴有多器官功能障碍。在这种情况下,气管切开术的早期干预可以挽救生命,并有助于预防与之相关的发病率和死亡率。
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引用次数: 0
Invited commentary on “The impact of the first wave of the COVID-19 pandemic on hospital admissions and treatment management of ectopic pregnancy” 特邀评论《第一波新冠肺炎疫情对异位妊娠住院及治疗管理的影响》
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.4103/tjem.tjem_175_23
FikriM Abu-Zidan
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引用次数: 0
Accidents and injuries related to paragliding on mount Babadağ, Turkey: A cross-sectional study 土耳其巴巴达尔山滑翔伞事故与伤害:一项横断面研究
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.4103/tjem.tjem_67_23
Yalcin Golcuk, ÖmerFaruk Karakoyun
OBJECTIVES: In light of the growing popularity of paragliding, this cross-sectional study aimed to investigate the epidemiology of paragliding accidents, providing insights into the types and severity of injuries sustained as well as the body regions most commonly affected. METHODS: This cross-sectional retrospective study utilized data on adverse paragliding events on Mount Babadağ in Turkey, collected by the Muğla Sports Tourism Board (STB) between January 2020 and December 2021, with data sources including out-of-hospital STB forms and in-hospital electronic health records. RESULTS: Out of 241,420 paragliding flights, a total of 44 accidents were identified, with only three resulting in fatalities. Most of the accidents occurred during take off and landing, but the deadliest phase was during flight. The majority of accidents were of low severity, with a median National Advisory Committee for Aeronautics score of 1 (interquartile range [IQR] 1–3) and a median injury severity score of 1 (IQR 1–7.75). The lower limb was the most commonly injured body part, accounting for 55.8% of injuries, followed by the upper limb at 30.8%. CONCLUSIONS: Despite being considered an extreme sport, paragliding carries a relatively low risk of accidents and serious injuries, owing to advancements in training, equipment inspection, and protective gear.
{"title":"Accidents and injuries related to paragliding on mount Babadağ, Turkey: A cross-sectional study","authors":"Yalcin Golcuk, ÖmerFaruk Karakoyun","doi":"10.4103/tjem.tjem_67_23","DOIUrl":"https://doi.org/10.4103/tjem.tjem_67_23","url":null,"abstract":"OBJECTIVES: In light of the growing popularity of paragliding, this cross-sectional study aimed to investigate the epidemiology of paragliding accidents, providing insights into the types and severity of injuries sustained as well as the body regions most commonly affected. METHODS: This cross-sectional retrospective study utilized data on adverse paragliding events on Mount Babadağ in Turkey, collected by the Muğla Sports Tourism Board (STB) between January 2020 and December 2021, with data sources including out-of-hospital STB forms and in-hospital electronic health records. RESULTS: Out of 241,420 paragliding flights, a total of 44 accidents were identified, with only three resulting in fatalities. Most of the accidents occurred during take off and landing, but the deadliest phase was during flight. The majority of accidents were of low severity, with a median National Advisory Committee for Aeronautics score of 1 (interquartile range [IQR] 1–3) and a median injury severity score of 1 (IQR 1–7.75). The lower limb was the most commonly injured body part, accounting for 55.8% of injuries, followed by the upper limb at 30.8%. CONCLUSIONS: Despite being considered an extreme sport, paragliding carries a relatively low risk of accidents and serious injuries, owing to advancements in training, equipment inspection, and protective gear.","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135953337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the ST-segment in Occlusion Myocardial Infarction (OMI): Diagnosing the OMI-nous. 闭塞性心肌梗死(OMI) st段外:OMI- noous的诊断。
IF 0.9 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.4103/2452-2473.357333
Emre K Aslanger

The ST-segment elevation (STE) myocardial infarction (MI)/non-STEMI (NSTEMI) paradigm has been the central dogma of emergency cardiology for the last 30 years. Although it was a major breakthrough when it was first introduced, it is now one of the most important obstacles to the further progression of modern MI care. In this article, we trace why a disease with an established underlying pathology (acute coronary occlusion [ACO]) was unintentionally labeled with a surrogate electrocardiographic sign (STEMI/NSTEMI) instead of pathologic substrate itself (ACO-MI/non-ACO-MI or occlusion MI [OMI]/non-OMI [NOMI] for short), how this fundamental mistake caused important clinical consequences, and why we should change this paradigm with a better one, namely OMI/NOMI paradigm.

st段抬高(STE)型心肌梗死(MI)/非stemi (NSTEMI)模式在过去30年中一直是急诊心脏病学的中心教条。虽然它最初被引入时是一个重大突破,但现在它是现代心肌梗死治疗进一步发展的最重要障碍之一。在这篇文章中,我们追踪了为什么一种具有确定的潜在病理(急性冠状动脉闭塞[ACO])的疾病在无意中被标记为替代心电图标志(STEMI/NSTEMI),而不是病理底物本身(ACO-MI/非ACO-MI或简称闭塞MI [OMI]/非OMI [NOMI]),这个根本性的错误是如何导致重要的临床后果的,以及为什么我们应该用更好的范式来改变这种范式,即OMI/NOMI范式。
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引用次数: 2
期刊
Turkish Journal of Emergency Medicine
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