Asian Journal of Urology最新文献_第10页

Research progress of the Hippo signaling pathway in renal cell carcinoma 肾细胞癌中 Hippo 信号通路的研究进展

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology

Pub Date : 2024-10-01 DOI: 10.1016/j.ajur.2024.02.005

Objective

This review aimed to summarize the role of the Hippo signaling pathway in renal cell carcinoma (RCC), a urologic malignancy with subtle initial symptoms and high mortality rates due to metastatic RCC. The Hippo signaling pathway, which regulates tissue and organ sizes, plays a crucial role in RCC progression and metastasis. Understanding the involvement of the Hippo signaling pathway in RCC provides valuable insights for the development of targeted therapies and improved patient outcomes.

Methods

In this review, we explored the impact of the Hippo signaling pathway on RCC. Through an analysis of existing literature, we examined its role in RCC progression and metastasis. Additionally, we discussed potential therapeutic strategies targeting the Hippo pathway for inhibiting RCC cell growth and invasion. We also highlighted the importance of investigating interactions between the Hippo pathway and other signaling pathways such as Wnt, transforming growth factor-beta, and PI3K/AKT, which may uncover additional therapeutic targets.

Results

The Hippo signaling pathway has shown promise as a target for inhibiting RCC cell growth and invasion. Studies have demonstrated its dysregulation in RCC, with altered expression of key components such as yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ). Targeting the Hippo pathway has been associated with suppressed tumor growth and metastasis in preclinical models of RCC. Furthermore, investigating crosstalk between the Hippo pathway and other signaling pathways has revealed potential synergistic effects that could be exploited for therapeutic interventions.

Conclusion

Understanding the role of the Hippo signaling pathway in RCC is of paramount importance. Elucidating its functions and molecular interactions contributes to RCC diagnosis, treatment, and the discovery of novel mechanisms. This knowledge informs the development of innovative therapeutic strategies and opens new avenues for research in RCC. Further investigations are warranted to fully comprehend the complex interplay between the Hippo pathway and other signaling pathways, ultimately leading to improved outcomes for RCC patients.

目的本综述旨在总结Hippo信号通路在肾细胞癌（RCC）中的作用，肾细胞癌是一种泌尿系统恶性肿瘤，初期症状不明显，但由于转移性RCC死亡率很高。Hippo信号通路可调节组织和器官的大小，在RCC的进展和转移中起着至关重要的作用。方法在这篇综述中，我们探讨了Hippo信号通路对RCC的影响。通过对现有文献的分析，我们研究了其在 RCC 进展和转移中的作用。此外，我们还讨论了针对 Hippo 通路抑制 RCC 细胞生长和侵袭的潜在治疗策略。我们还强调了研究 Hippo 通路与 Wnt、转化生长因子-β 和 PI3K/AKT 等其他信号通路之间相互作用的重要性，这可能会发现更多的治疗靶点。研究表明，Hippo 信号通路在 RCC 中失调，其关键成分的表达发生了改变，如具有 PDZ 结合基调（YAP/TAZ）的 "是 "相关蛋白/转录辅激活因子。在 RCC 的临床前模型中，靶向 Hippo 通路与抑制肿瘤生长和转移有关。此外，研究 Hippo 通路与其他信号通路之间的串扰发现了潜在的协同效应，可用于治疗干预。阐明其功能和分子相互作用有助于 RCC 的诊断、治疗和新机制的发现。这些知识为创新治疗策略的开发提供了依据，并为 RCC 的研究开辟了新途径。我们有必要开展进一步的研究，以全面了解 Hippo 通路与其他信号通路之间复杂的相互作用，最终改善 RCC 患者的预后。

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引用次数: 0

Urinary incontinence among Jordanian women: Prevalence, types, and associated factors 约旦妇女的尿失禁情况：发病率、类型和相关因素

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology

Pub Date : 2024-10-01 DOI: 10.1016/j.ajur.2023.11.003

Objective

Urinary incontinence (UI) is a prevalent condition with a negative impact on women's quality of life. Data about UI among Jordanian women are lacking; therefore, we aimed to investigate the prevalence, types, and associated factors.

Methods

A cross sectional nationwide survey was conducted between 1 March 2020 and 15 April 2020. Women were included if they were 18 years of age or more and had access to the internet. Data collected included women's characteristics, UI types, and associated factors. UI was inventoried by asking women if they have UI (yes/no), and the Arabic language validated International Consultation on Incontinence Questionnaire Urinary Incontinence-Short Form was used. Age-group specific prevalence rates of UI were estimated, and associated factors were studied using logistic regression analyses.

Results

Data from 2118 women were analysed. The median age was 40 (range 18–85) years; 58.3% gave birth three or more times; and 64.1% consistently reported having UI. Limited mobility and being multiparous increased the likelihood of reporting UI. Compared to women with normal body mass index, overweight and obese women were 1.9 times and 4.4 times more likely to report UI, respectively.

Conclusion

The prevalence of UI among Jordanian women is 64.1%, with mixed UI and stress UI being the more prevalent types in women younger than 60 years old. Age, parity body mass index, and limited mobility are all associated factors with UI. The results of this study provide healthcare policy makers with the necessary information to increase awareness and knowledge regarding UI.

目的尿失禁（UI）是一种普遍存在的疾病，对妇女的生活质量有负面影响。有关约旦女性尿失禁的数据十分匮乏，因此，我们旨在调查尿失禁的患病率、类型和相关因素。方法 2020 年 3 月 1 日至 2020 年 4 月 15 日期间，我们在全国范围内开展了一项横断面调查。年满 18 周岁并能上网的女性均被纳入调查范围。收集的数据包括女性特征、UI 类型和相关因素。通过询问妇女是否患有尿失禁（是/否）来调查尿失禁情况，并使用阿拉伯语的尿失禁国际咨询问卷尿失禁简表。结果分析了 2118 名妇女的数据。中位年龄为 40 岁（18-85 岁不等）；58.3% 的妇女生育过三次或三次以上；64.1% 的妇女一直报告患有尿失禁。行动不便和多胎妊娠增加了报告尿失禁的可能性。与体重指数正常的妇女相比，超重和肥胖妇女报告尿崩症的可能性分别增加了 1.9 倍和 4.4 倍。年龄、奇偶体重指数和行动不便都是导致尿失禁的相关因素。这项研究的结果为医疗决策者提供了必要的信息，以提高对尿崩症的认识和了解。

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引用次数: 0

Long-term outcomes of erectile function in adult orchidopexy patients 成人睾丸切除术患者勃起功能的长期疗效

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology

Pub Date : 2024-10-01 DOI: 10.1016/j.ajur.2024.02.001

Objective

Cryptorchidism affects up to 6% of full-term male infants, and orchidopexy has been shown to reduce impaired spermatogenesis and malignant risks significantly. However, the relationship between orchidopexy and sexual function has not been investigated. Therefore, this study aimed to evaluate sexual function outcomes in adult patients who underwent orchidopexy for unilateral undescended testis in childhood.

Methods

Totally, 58 adult patients who underwent unilateral orchidopexy in childhood were enrolled in the study. Erectile dysfunction (ED) was assessed by the International Index of Erectile Function (IIEF)-15 questionnaire. All participants underwent serum (testosterone and follicular stimulating hormone levels) measurement and semen analysis. Paternity rates were evaluated to assess the patient's fertility. Additionally, anxiety, depression, and stress were measured by the self-rating anxiety scale, self-rating depression scale, and visual analogue scale, respectively.

Results

There was no statistically significant difference between IIEF-15 scores (intercourse satisfaction, orgasmic function, sexual desire, or overall satisfaction) comparing the cryptorchidism group with the control group; however, the ED was significantly higher in the cryptorchidism patients (p=0.000). At the median follow-up of 16.3 years, 15.5% of our patients complained of moderate to severe ED. Most patients were satisfied with their overall relationship and only 34.5% were not satisfied. Anxiety, depression, and stress were more prevalent in cryptorchidism than in healthy men (anxiety: 72.4% vs. 20.7%; depression: 19.0% vs. 5.2%; stress: 60.3% vs. 10.3%; p˂0.05). Additionally, ED was negatively associated with anxiety, depression, and stress symptoms (r=−0.518, p=0.000; r=−0.448, p=0.000; r=−0.591, p=0.000, respectively). Moreover, ED had a significant correlation with advancing age, psychological factors (anxiety, depression, and stress), infertility, and low levels of testosterone (p˂0.05).

Conclusion

Low testosterone, infertility, and psychological burden (anxiety, depression, and stress) are used as factors for predicting ED outcomes after orchidopexy for undescended testis to guide physicians to evaluate the efficacy of testosterone replacement and psychological support in their management.

目的隐睾症影响着多达 6% 的足月男婴，睾丸整形术已被证明能显著减少精子发生障碍和恶性风险。然而，睾丸整形术与性功能之间的关系尚未得到研究。因此，本研究旨在评估儿童时期因单侧睾丸下降不全而接受睾丸固定术的成年患者的性功能结果。勃起功能障碍（ED）通过国际勃起功能指数（IIEF）-15问卷进行评估。所有参与者都接受了血清（睾酮和促卵泡激素水平）测量和精液分析。对亲子鉴定率进行了评估，以评估患者的生育能力。此外，焦虑、抑郁和压力分别通过焦虑自评量表、抑郁自评量表和视觉模拟量表进行测量。结果隐睾症组与对照组相比，IIEF-15评分（性交满意度、性高潮功能、性欲或总体满意度）差异无统计学意义；但隐睾症患者的ED显著较高（P=0.000）。在中位 16.3 年的随访中，15.5% 的患者主诉有中度至重度 ED。大多数患者对他们的总体关系表示满意，只有 34.5% 的患者表示不满意。焦虑、抑郁和压力在隐睾症患者中的发病率高于健康男性（焦虑：72.4% 对 20.7%；抑郁：19.0% 对 5.2%；压力：60.3% 对 10.2%）：60.3%对10.3%；P˂0.05）。此外，ED 与焦虑、抑郁和压力症状呈负相关（分别为 r=-0.518，p=0.000；r=-0.448，p=0.000；r=-0.591，p=0.000）。此外，ED与年龄增长、心理因素（焦虑、抑郁和压力）、不育和低水平睾酮有明显相关性（p˂0.05）。结论低水平睾酮、不育和心理负担（焦虑、抑郁和压力）可作为预测睾丸下降术后ED结果的因素，以指导医生评估睾酮替代和心理支持在治疗中的疗效。

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引用次数: 0

A unusual complication following self-catheterization in a young female 一名年轻女性自我导尿后出现的异常并发症

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology

Pub Date : 2024-10-01 DOI: 10.1016/j.ajur.2023.10.005

引用次数: 0

Hyper accuracy three-dimensional virtual anatomical rainbow model facilitates surgical planning and safe selective clamping during robot-assisted partial nephrectomy 高精度三维虚拟解剖彩虹模型有助于机器人辅助肾部分切除术中的手术规划和安全选择性钳夹

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology

Pub Date : 2024-10-01 DOI: 10.1016/j.ajur.2023.08.006

Objective

To highlight the role of hyper accuracy three-dimensional (3D) reconstruction in facilitating surgical planning and guiding selective clamping during robot-assisted partial nephrectomy (RAPN).

Methods

A transperitoneal RAPN was performed in a 62-year-old male patient presenting with a 4 cm right anterior interpolar renal mass (R.E.N.A.L nephrometry score 7A). An abnormal vasculature was observed, with a single renal vein and two right renal arteries originating superiorly to the vein and anterior, when dividing in their segmental branches. According to the hyper accuracy 3D (HA3D®) rainbow model (MEDICS Srl, Turin, Italy), one branch belonging to one of the segmental arteries was feeding the tumor. This allowed for an accurate prediction of the area vascularized by each arterial branch. The 3D model was included in the intraoperative console view during the whole procedure, using the TilePro feature. A step-by-step explanation of the procedure is provided in the video attached to the present article.

Results

The operative time was 90 min with a warm ischemia time on selective clamping of 13 min. Estimated blood loss was 180 mL. No intraoperative complication was encountered and no drain was placed at the end of the procedure. The patient was discharged on postoperative Day 2, without any early postoperative complications. The final pathology report showed a pathological tumor stage 1 clear cell renal cell carcinoma with negative surgical margins.

Conclusion

The present study and the attached video illustrate the value of 3D rainbow model during the planning and execution of a RAPN with selective clamping. It shows how the surgeon can rely on this model to be more efficient by avoiding unnecessary surgical steps, and to safely adopt a “selective” clamping strategy that can translate in minimal functional impact.

方法对一名 62 岁的男性患者进行了经腹腔镜肾部分切除术，患者患有 4 厘米右肾前极间肿块（R.E.N.A.L 肾测量评分 7A）。观察到血管异常，一条肾静脉和两条右肾动脉在分段分支时起源于静脉上方和前方。根据超精确三维（HA3D®）彩虹模型（MEDICS Srl，意大利都灵），属于其中一条节段动脉的分支正在为肿瘤供血。这样就能准确预测每条动脉分支的血管区域。在整个手术过程中，三维模型通过 TilePro 功能显示在术中控制台视图中。手术时间为 90 分钟，选择性钳夹的热缺血时间为 13 分钟。估计失血量为 180 毫升。术中未出现并发症，术后也未放置引流管。患者于术后第 2 天出院，术后早期未出现任何并发症。最终病理报告显示，肿瘤病理分期为 1 期透明细胞肾细胞癌，手术切缘阴性。它展示了外科医生如何依靠该模型避免不必要的手术步骤，从而提高效率，并安全地采用 "选择性 "夹闭策略，将功能影响降至最低。

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引用次数: 0

An evaluation of ureteral diameter ratio and vesicoureteral reflux index in the treatment of primary vesicoureteral reflux 输尿管直径比和膀胱输尿管反流指数在治疗原发性膀胱输尿管反流中的应用评估

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology

Pub Date : 2024-07-01 DOI: 10.1016/j.ajur.2023.05.007

Objective

Vesicoureteral reflux (VUR) index is a simple, validated tool that reliably predicts significant improvement and spontaneous resolution of primary reflux in children. The aim of this study was to evaluate and compare the ureter diameter ratio (UDR) and VUR index (VURx) of patients treated with endoscopic injection (EI) and ureteroneocystostomy (UNC) methods in the pediatric age group due to primary VUR.

Methods

Patients under the age of 18 years old who underwent EI and UNC with the diagnosis of primary VUR between January 2011 and September 2021 were determined as the participants. The UDR was assessed using voiding cystourethrography, and the VURx score was determined prior to treatment based on hospital records included in the study.

Results

A total of 255 patients, 60 (23.5%) boys and 195 (76.5%) girls, with a mean age of 76.5 (range 13.0–204.0) months, were included in the study. EI was applied to 130 (51.0%) patients and UNC was applied to 125 (49.0%) patients due to primary VUR. The optimum cut-off for the distal UDR was obtained as 0.17 with sensitivity and specificity of 73.0% and 63.0%, respectively. The positive and negative predictive values were 66.0% and 70.0%, respectively.

Conclusion

When the UDR and VURx score are evaluated together for the surgical treatment of primary VUR in the pediatric age group, it is thought that it may be useful in predicting the clinical course of the disease and evaluating surgical treatment options.

目的膀胱输尿管反流（VUR）指数是一种简单、有效的工具，能可靠地预测儿童原发性反流的显著改善和自发缓解。本研究旨在评估和比较因原发性输尿管返流而接受内窥镜注射（EI）和输尿管膀胱造口术（UNC）治疗的儿科年龄组患者的输尿管直径比（UDR）和输尿管返流指数（VURx）。研究共纳入 255 例患者，其中男孩 60 例（23.5%），女孩 195 例（76.5%），平均年龄 76.5 个月（13.0-204.0 个月）。130 名（51.0%）患者采用了 EI，125 名（49.0%）原发性 VUR 患者采用了 UNC。远端 UDR 的最佳临界值为 0.17，灵敏度和特异度分别为 73.0% 和 63.0%。结论当 UDR 和 VURx 评分一起用于评估儿科原发性 VUR 的手术治疗时，它可能有助于预测疾病的临床过程和评估手术治疗方案。

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引用次数: 0

Understanding female urinary continence—lessons from complications of female urethral surgery 了解女性尿失禁--女性尿道手术并发症的启示

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology

Pub Date : 2024-07-01 DOI: 10.1016/j.ajur.2024.01.009

引用次数: 0

Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study 使用酪氨酸激酶抑制剂作为转移性肾细胞癌患者一线治疗的最佳序贯疗法:一项全国多中心研究

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology

Pub Date : 2024-07-01 DOI: 10.1016/j.ajur.2022.11.004

Objective

The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor (TKI) as the first-line therapy for patients with metastatic renal cell carcinoma (mRCC) in terms of overall survival (OS), progression-free survival (PFS), and rates of discontinuation and adverse effects during the treatment period.

Methods

This is a retrospective, nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December 2017. We focused on patients at either “favorable” or “intermediate” risk according to the International mRCC Database Consortium criteria, and they were followed up (median 335 days). Finally, a total of 1409 patients were selected as the study population. We generated a Cox proportional hazard model adjusted for covariates, and the different therapy schemes were statistically tested in terms of OS as well as PFS. In addition, frequencies of discontinuation and adverse events were compared among the therapy schemes.

Results

Of the primary patterns of treatment sequences (24 sequences), “sunitinib–pazopanib” and “sunitinib–everolimus–immunotherapy” showed the most beneficial results in both OS and PFS with significantly lower hazards than “sunitinib”, which is the most commonly treated agent in Korea. Considering that the “TKI–TKI” structure showed relatively higher discontinuation rates with higher adverse effects, the overall beneficial sequence would be “sunitinib–everolimus–immunotherapy”.

Conclusion

Among several sequential therapy starting with TKIs, “sunitinib–everolimus– immunotherapy” was found to be the best scheme for mRCC patients with “favorable” or “intermediate” risks.

目的本研究旨在从总生存期（OS）、无进展生存期（PFS）以及治疗期间的停药率和不良反应等方面，确定转移性肾细胞癌（mRCC）患者以酪氨酸激酶抑制剂（TKI）作为一线疗法的最佳治疗顺序。方法这是一项回顾性全国多中心研究，研究对象为1992年1月至2017年12月期间在韩国10家不同的三级医疗中心确诊后的mRCC患者。根据国际 mRCC 数据库联盟的标准，我们重点研究了 "有利 "或 "中等 "风险的患者，并对他们进行了随访（中位数为 335 天）。最后，我们共选择了1409名患者作为研究对象。我们生成了一个经协变量调整的 Cox 比例危险模型，并对不同治疗方案的 OS 和 PFS 进行了统计学检验。结果在主要的治疗序列模式（24 个序列）中，"舒尼替尼-帕唑帕尼 "和 "舒尼替尼-依维莫司-免疫疗法 "在 OS 和 PFS 方面都显示出最有利的结果，其危险性明显低于 "舒尼替尼"，而 "舒尼替尼 "是韩国最常用的治疗药物。考虑到 "TKI-TKI "结构显示出相对较高的停药率和较高的不良反应，"舒尼替尼-依维莫司-免疫疗法 "将是总体有利的序列。

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引用次数: 0

Mesenchymal stem cell secretome: A promising therapeutic strategy for erectile dysfunction? 间充质干细胞分泌组：治疗勃起功能障碍的有效策略？

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology

Pub Date : 2024-07-01 DOI: 10.1016/j.ajur.2024.02.003

Objective

The secretome, comprising bioactive chemicals released by mesenchymal stem cells (MSCs), holds therapeutic promise in regenerative medicine. This review aimed to explore the therapeutic potential of the MSC secretome in regenerative urology, particularly for treating erectile dysfunction (ED), and to provide an overview of preclinical and clinical research on MSCs in ED treatment and subsequently to highlight the rationales, mechanisms, preclinical investigations, and therapeutic potential of the MSC secretome in this context.

Methods

The review incorporated an analysis of preclinical and clinical research involving MSCs in the treatment of ED. Subsequently, it delved into the existing knowledge regarding the MSC secretome, exploring its therapeutic potential. The methods included a comprehensive examination of relevant literature to discern the processes underlying the therapeutic efficacy of the MSC secretome.

Results

Preclinical research indicated the effectiveness of the MSC secretome in treating various models of ED. However, the precise mechanisms of its therapeutic efficacy remain unknown. The review provided insights into the anti-inflammatory, pro-angiogenic, and trophic properties of the MSC secretome. It also discussed potential advantages, such as avoiding issues related to cellular therapy, including immunogenicity, neoplastic transformation, and cost.

Conclusion

This review underscores the significant therapeutic potential of the MSC secretome in regenerative urology, particularly for ED treatment. While preclinical studies demonstrate promising outcomes, further research is essential to elucidate the specific mechanisms underlying the therapeutic efficacy before clinical application. The review concludes by discussing future perspectives and highlighting the challenges associated with the clinical translation of the MSC secretome in regenerative urology.

目的由间充质干细胞释放的生物活性化学物质组成的分泌组在再生医学中具有治疗前景。这篇综述旨在探讨间充质干细胞分泌组在再生泌尿学中的治疗潜力，尤其是治疗勃起功能障碍（ED）的潜力，并概述间充质干细胞治疗ED的临床前和临床研究，随后强调间充质干细胞分泌组在这方面的原理、机制、临床前研究和治疗潜力。随后，它深入研究了有关间充质干细胞分泌组的现有知识，并探讨了其治疗潜力。研究方法包括对相关文献进行全面检查，以了解间充质干细胞分泌组治疗功效的基本过程。然而，其疗效的确切机制仍然未知。综述深入探讨了间充质干细胞分泌组的抗炎、促血管生成和营养特性。本综述强调了间充质干细胞分泌组在再生泌尿外科，尤其是 ED 治疗方面的巨大治疗潜力。虽然临床前研究显示了良好的结果，但在临床应用之前，进一步的研究对于阐明治疗效果的具体机制至关重要。综述最后讨论了未来的前景，并强调了间充质干细胞分泌组在再生泌尿外科临床转化过程中面临的挑战。

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引用次数: 0

Uncovering the epidemiology of bladder cancer in the Arab world: A review of risk factors, molecular mechanisms, and clinical features 揭示阿拉伯世界的膀胱癌流行病学：风险因素、分子机制和临床特征综述

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology

Pub Date : 2024-07-01 DOI: 10.1016/j.ajur.2023.10.001

Objective

Bladder cancer (BC) is a significant public health concern in the Middle East and North Africa, but the epidemiology and clinicopathology of the disease and contributors to high mortality in this region remain poorly understood. The aim of this systematic review was to investigate the epidemiological features of BC in the Arab world and compare them to those in Western countries in order to improve the management of this disease.

Methods

An extensive electronic search of the PubMed/PMC and Cochrane Library databases was conducted to identify all articles published until May 2022, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. A total of 95 articles were included in the final analysis after title, abstract, and full-text screening, with additional data obtained from the GLOBOCAN and WHO 2020 databases.

Results

Most of the included articles were case-control studies examining the risk factors and molecular mechanisms of BC. These studies originated from 10 different countries, with Egypt being the most active contributor. While BC in the Arab world shares some common risk factors with Western countries, such as smoking and occupational exposure, it also exhibits unique features related to schistosomiasis. The high mortality rates in this region are alarming and can be attributed to various factors, including the prevalence of smoking, the impact of schistosomiasis, a combination of genetic and socioeconomic factors, treatment shortages, and limited access to care or inadequate assessment of the quality of care.

Conclusion

Despite the relatively low incidence of BC in Arab countries, the mortality rates are among the highest worldwide. BC tends to be more aggressive in the Arab world, making it essential to implement strategies to address this burden.

目的膀胱癌（BC）是中东和北非地区的一个重大公共卫生问题，但人们对该疾病的流行病学和临床病理学以及造成该地区高死亡率的原因仍然知之甚少。本系统综述旨在研究阿拉伯世界膀胱癌的流行病学特征，并将其与西方国家的流行病学特征进行比较，以改进对该疾病的管理。方法按照《系统综述和元分析首选报告项目》指南，对PubMed/PMC和Cochrane图书馆数据库进行了广泛的电子检索，以确定截至2022年5月发表的所有文章。经过标题、摘要和全文筛选，共有95篇文章被纳入最终分析，其他数据来自GLOBOCAN和WHO 2020数据库。这些研究来自 10 个不同的国家，其中埃及的研究最为活跃。虽然阿拉伯世界的BC与西方国家有一些共同的风险因素，如吸烟和职业暴露，但它也表现出与血吸虫病相关的独特特征。该地区的高死亡率令人震惊，可归因于多种因素，包括吸烟率、血吸虫病的影响、遗传和社会经济因素的综合作用、治疗短缺、获得护理的机会有限或对护理质量的评估不足。在阿拉伯世界，BC 的侵袭性更强，因此必须实施相关战略来解决这一问题。

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引用次数: 0