Although race is socially constructed, racism and racialization are social determinants of health. Over four centuries of colonial genocide and structural violence against Indigenous and Black peoples in Canada have resulted in intergeneration traumas and health disparities among Indigenous and Black people, sustained by ongoing social, political, and economic inequities. Evidence indicates the impact of contemporary and historical forms of racism on health outcomes. This special issue invited papers that could contribute to our understanding of the role of racism in nursing and health in Canada as well as solutions to tackle racism in healthcare and the nursing profession. Our call for proposals produced around 16 articles, all of which provide critical insight to address racism in nursing and healthcare. These articles explore the experience of racism in Indigenous, Black, Asian, and other populations across education, clinical, and community settings. They also advance our understanding on philosophical and theoretical approaches to address racism and provide us with effective tools and insight to address racism in nursing and healthcare in Canada.