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Impact of gender identity in the inflammatory bowel disease population: an evidence review and practical steps for gastroenterologists 炎症性肠病患者性别认同的影响:证据综述和消化科医生的实用步骤
IF 2.6 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-11 DOI: 10.1136/flgastro-2024-102658
Michael Colwill, Richard Pollok, Leighton Seal, Andrew Poullis
There has been greater societal awareness of differences in gender identity and sexual orientation in recent years. The rates of identifying as transgender or gender non-conforming (TGNC) are increasing and are known to be higher in the younger population and will therefore be over-represented in the inflammatory bowel disease (IBD) subpopulation. However, despite this there is very little in the literature with regards to those who identify as TGNC and are diagnosed with IBD (TGNC-IBD). Many TGNC individuals have poor experiences when seeking healthcare and many physicians find it a challenging and daunting clinical situation to be faced with. We reviewed the available literature with regards to TGNC-IBD population demographics, physical, mental and sexual health considerations, medication interactions and implications for surgery in this heterogenous group. We have identified areas that need further research and suggested simple and practical steps that can be adopted in order to help healthcare providers improve the experience for TGNC individuals diagnosed with IBD and the quality of care they provide.
近年来,社会对性别认同和性取向差异的认识有所提高。变性人或性别不符者(TGNC)的比例正在上升,而且众所周知,年轻群体中变性人或性别不符者的比例更高,因此在炎症性肠病(IBD)亚群中的比例也会更高。然而,尽管如此,有关那些被诊断为 IBD(TGNC-IBD)的 TGNC 的文献却很少。许多 TGNC 患者在寻求医疗保健服务时经历不佳,而许多医生也认为这是一种具有挑战性和令人生畏的临床情况。我们查阅了有关 TGNC-IBD 群体人口统计学、生理、心理和性健康考虑因素、药物相互作用以及对这一异质群体进行手术的影响等方面的现有文献。我们确定了需要进一步研究的领域,并提出了可以采取的简单而实用的步骤,以帮助医疗服务提供者改善被诊断患有 IBD 的 TGNC 患者的就医体验,并提高他们所提供的医疗服务质量。
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引用次数: 0
Cross-sectional evaluation of online direct-to-public calprotectin testing 对直接面向公众的在线钙黏蛋白检测进行横断面评估
IF 2.6 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-26 DOI: 10.1136/flgastro-2024-102644
Maria Bishara, Rebecca Smith, Christopher Roberts, Yousra Djouider, Claire Bewshea, Rachel Nice, Nicholas A Kennedy, James R Goodhand, Tariq Ahmad
Objective Why about a quarter of patients with inflammatory bowel disease (IBD) suffer symptoms for more than a year before their diagnosis made is unclear. Low public awareness, embarrassment and the apprehension of invasive tests are cited. The anonymity of direct-to-public calprotectin testing may overcome these barriers. We sought to characterise what calprotectin testing is available directly to the public in the UK. Design/method We conducted a cross-sectional evaluation of the calprotectin assays available online in the UK. Collection kits were procured from eligible providers, and surplus stool tested to receive follow-up advice for known positive (>50–100 μg/g) and negative (<50 μg/g) stool samples. Results Half (54.5% (6/11)) of the available tests were home lateral flow tests and the remainder were laboratory-based ELISAs. The lateral flow tests were considerably cheaper than the laboratory-based tests (median (range) cost £14.20 (£7.85–21.00) vs £75.85 (£59–151), p<0.0001). The median turnaround time for the laboratory tests was 14 (range: 1–23) days. All but one provider used a positivity threshold of 50 μg/g. All tests included written and pictorial instructions with the testing kit. Contact with a physician was recommended for similar proportions of positive and negative calprotectin results (54.5% (6/11) vs 54.5% (6/11), p=1). Conclusion In the UK, the public can choose between inexpensive home-based lateral flow tests or send stool samples for gold-standard laboratory testing of calprotectin. The low cost and rapid turnaround times suggest that direct-to-public calprotectin testing could be promoted to try to reduce the time to IBD diagnosis. Data are available upon reasonable request. The data will be made available to investigators whose proposed use of the data has been approved by an independent review committee. Analyses will be restricted to the aims in the approved proposal. Proposals should be directed to Tariq Ahmad (tariq.ahmad1@nhs.net). To gain full access data, requestors will need to sign a data access agreement.
目标 为什么约有四分之一的炎症性肠病(IBD)患者在确诊前一年多才出现症状,目前尚不清楚。公众意识薄弱、尴尬和对侵入性检查的恐惧是原因之一。直接面向公众的钙蛋白检测的匿名性可能会克服这些障碍。我们试图了解英国公众可直接进行哪些钙黏蛋白检测。设计/方法 我们对英国在线提供的钙黏蛋白检测方法进行了横向评估。我们从符合条件的提供商处购买了采集工具包,并对多余的粪便进行了检测,以获得对已知阳性(>50-100 μg/g)和阴性(<50 μg/g)粪便样本的后续建议。结果 半数(54.5% (6/11))可用的检测方法是家庭横向流动检测,其余是实验室 ELISA。横向流动检测比实验室检测便宜得多(费用中位数(范围)为 14.20 英镑(7.85-21.00 英镑)vs 75.85 英镑(59-151 英镑),p<0.0001)。实验室检测的周转时间中位数为 14 天(范围:1-23 天)。除一家医疗机构外,其他医疗机构的阳性阈值均为 50 微克/克。所有检测项目都随检测试剂盒附有书面和图解说明。钙黏蛋白检测结果呈阳性和阴性的比例相似(54.5% (6/11) vs 54.5% (6/11),p=1),建议与医生联系。结论 在英国,公众可以选择价格低廉的家用侧流试验或将粪便样本送往金标准实验室检测钙黏蛋白。低成本和快速的周转时间表明,可以推广直接面向公众的钙黏蛋白检测,以缩短 IBD 诊断时间。如有合理要求,可提供相关数据。数据将提供给其数据使用建议已获独立审查委员会批准的研究人员。分析将仅限于已获批准的提案中的目标。建议应直接提交给 Tariq Ahmad (tariq.ahmad1@nhs.net)。申请者需要签署一份数据访问协议,才能完全访问数据。
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引用次数: 0
Delayed colonic perforation secondary to cold snare polypectomy 冷套管息肉切除术继发的延迟性结肠穿孔
IF 2.6 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-26 DOI: 10.1136/flgastro-2024-102742
Jan Kubovy, Matthew Drake, Rajan N Patel
Cold snare polypectomy (CSP) is the treatment of choice for polyps less than 10 mm in size and sessile serrated lesions.1 We present a 66-year-old woman with Crohn’s colitis. Inflammatory bowel disease (IBD) was in complete clinico-endoscopic remission and colonoscopy was performed for dysplasia surveillance. …
冷套管息肉切除术(CSP)是治疗小于 10 毫米的息肉和无柄锯齿状病变的首选方法。炎症性肠病(IBD)在临床内镜下已完全缓解,结肠镜检查是为了监测发育不良。...
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引用次数: 0
Uncommon cause of pancreatitis 20 years after cholecystectomy 胆囊切除术后 20 年胰腺炎的罕见病因
IF 2.6 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-20 DOI: 10.1136/flgastro-2024-102764
Heng Chi, Michael Staessens, Wim J Lammers, Pieter Jan F de Jonge
A 65-year-old woman with a medical history of cholecystectomy 20 years ago was referred to our hospital for recurrent colic pain in the upper abdomen with intermittent cholestatic liver enzyme abnormalities. She also experienced an episode of acute pancreatitis 2 weeks before the presentation. CT showed a dilated common bile duct with a hyperdense object of 10×4 mm in the distal common bile duct, suspecting …
一名 65 岁的妇女 20 年前曾做过胆囊切除术,因上腹反复绞痛并伴有间歇性胆汁淤积性肝酶异常而转诊至我院。就诊前两周,她还经历过一次急性胰腺炎发作。CT显示胆总管扩张,胆总管远端有一个10×4毫米的高密度物,怀疑...
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引用次数: 0
Rwandan man with a case of the blues 患忧郁症的卢旺达人
IF 2.6 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-20 DOI: 10.1136/flgastro-2024-102722
Benjamin Wipper, Hanna Blaney, Robert Giraneza, Prosper Ingabire, Vincent Dusabejambo, Udit Asija, Erik C von Rosenvinge
A Rwandan man in his 40s underwent an upper gastrointestinal endoscopy for evaluation of solid-food dysphagia. Of note, the patient also reported a long-standing history of anaemia, which was originally diagnosed in 2000. He had required four transfusions since and noted that he had previously been prescribed tot’hema syrup (a form of iron supplementation) but was no longer taking it. Laboratory tests around the time of endoscopy showed microcytic anaemia (haemoglobin 99.1 g/L, median corpuscular volume 61.84 fL) with an elevated reticulocyte count (91×109/L). Further labs showed low serum iron (28 mcg/dL) and ferritin (20.5 ng/mL). The patient denied ever experiencing melena or haematochezia. Endoscopic examination revealed a partially obstructing Schatzki’s ring as the explanation for his dysphagia and this was treated with balloon dilation. The endoscopy also revealed numerous blue-violet vascular-appearing …
一名 40 多岁的卢旺达男子因固体食物吞咽困难接受了上消化道内窥镜检查。值得注意的是,患者还报告了长期的贫血病史,最初于 2000 年确诊。从那时起,他需要进行四次输血,并指出他以前曾服用过tot'hema糖浆(一种铁质补充剂),但现在已不再服用。内窥镜检查前后的实验室检查显示他患有小细胞性贫血(血红蛋白 99.1 g/L,中位血球容积 61.84 fL),网织红细胞计数升高(91×109/L)。进一步化验结果显示血清铁(28 mcg/dL)和铁蛋白(20.5 ng/mL)偏低。患者否认曾出现过血块或血便。内窥镜检查显示,沙茨基环部分阻塞是导致其吞咽困难的原因,因此对其进行了球囊扩张治疗。内镜检查还发现了许多蓝紫色血管外观的...
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引用次数: 0
Whitish colonic mucosa 结肠粘膜变白
IF 2.6 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-18 DOI: 10.1136/flgastro-2024-102765
Joaquin Fisac-Vazquez, Laura G-Pastrian, Marta de Uribe-Viloria, Maria Dolores Martin-Arranz
An asymptomatic 65-year-old woman was referred to our endoscopy unit after a screening positive faecal occult blood test. Colonoscopy revealed a pale, whitish colonic mucosa with yellowish specks (figure 1), congestive areas and foci of lymphoid follicular hyperplasia (figure 2). Sessile lesions (0-Is) with whitish speckling on their surface were also identified. Figure 1 Whitish colonic mucosa with yellowish specks. Figure 2 Congestive areas and foci of lymphoid follicular hyperplasia. On histology, a dense infiltrate of foamy macrophages was …
一名无症状的 65 岁妇女在粪便潜血试验呈阳性后被转诊到我们的内镜室。结肠镜检查发现,结肠粘膜苍白,有淡黄色斑点(图 1)、充血区和淋巴滤泡增生灶(图 2)。此外,还发现了表面有白色斑点的无柄病变(0-Is)。图 1 带有淡黄色斑点的白色结肠粘膜。图 2 淋巴滤泡增生的充血区和病灶。组织学检查发现,泡沫状巨噬细胞密集浸润。
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引用次数: 0
Environmental impact assessment in healthcare: utility and limitations 医疗保健中的环境影响评估:实用性和局限性
IF 2.6 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-31 DOI: 10.1136/flgastro-2023-102473
Robin Baddeley, Nikolaos Voulvoulis, Siwan Thomas-Gibson, Bu'Hussain Hayee
Concern regarding the environmental impact of healthcare provision is now accompanied by a legal commitment for the NHS to align itself with national emissions targets. Meanwhile, the academic literature increasingly features environmental impact assessments focused on healthcare products, processes and systems. However, the current evidence base contains significant methodological heterogeneity, and the healthcare context demands that particular considerations are made when interpreting the findings from these studies. In this article, we consider the role environmental accounting methodologies can play in the effort to achieve environmental sustainability in healthcare; their utility and limitations.
在关注医疗服务对环境影响的同时,英国国家医疗服务体系(NHS)也做出了与国家排放目标保持一致的法律承诺。与此同时,学术文献也越来越多地关注医疗产品、流程和系统的环境影响评估。然而,目前的证据基础在方法上存在很大的不一致性,而且医疗保健的背景要求在解释这些研究结果时做出特别的考虑。在本文中,我们将探讨环境核算方法在努力实现医疗保健行业环境可持续性方面所能发挥的作用,以及这些方法的实用性和局限性。
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引用次数: 0
Unique cause of acute pancreatitis 急性胰腺炎的独特病因
IF 2.6 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-29 DOI: 10.1136/flgastro-2024-102673
Rory James McCluskey, Jessie Elliott, Jan Leyden, John Conneely, Gerry McEntee, Suzanne O'Mahony, Niall McInerney
A previously well 43-year-old men was admitted with right upper quadrant and epigastric pain, fever and vomiting. His medical history included asymptomatic cholestatic liver function tests for which serial ultrasound (US), magnetic resonance cholangiopancreatography, fibroscan and a US-guided liver biopsy had proved unremarkable several years prior to this presentation. Physical examination revealed diffuse abdominal tenderness worst in the right upper quadrant and epigastric region. Laboratory investigations demonstrated raised inflammatory markers and deranged liver function but were otherwise unremarkable. CT of the abdomen and pelvis showed extensive pancreatic stranding and fluid most prominent around the tail and body of the pancreas. The patient had no history of gallstones, alcohol misuse, new medications, family history or hypercholesterolemia. The patient was managed conservatively but subsequently deteriorated with features of abdominal sepsis. Serial …
一名 43 岁的男性因右上腹和上腹痛、发烧和呕吐入院。他的病史包括无症状性胆汁淤积性肝功能检查,在这次就诊前的几年里,连续的超声波(US)、磁共振胆胰造影、纤维扫描和 US 引导下的肝活检均未发现异常。体格检查显示,右上腹和上腹部弥漫性压痛最严重。实验室检查显示炎症标志物升高,肝功能异常,但其他方面无异常。腹部和盆腔CT显示,胰腺尾部和胰体周围有广泛的胰腺绞窄和积液。患者没有胆结石史、酗酒史、新服药史、家族史或高胆固醇血症史。患者接受了保守治疗,但随后病情恶化,出现腹腔败血症特征。连续...
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引用次数: 0
Climate change and gastroenterology: from the frontline 气候变化与肠胃病学:从第一线出发
IF 2.6 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-13 DOI: 10.1136/flgastro-2023-102500
Mai Ling Perman
Despite contributing minimally to global greenhouse gas emissions,1 Pacific Island nations are at the frontline of climate change impacts.2 Their heightened vulnerability stems from their geographical dispersal across the expansive Pacific Ocean, which leaves them encircled by vast bodies of water. This unique geological position subjects these island communities to climate-related threats, including rising sea levels, coastline erosion, ocean acidification, loss of biodiversity, food and water insecurities and extreme weather events, jeopardising their existence and way of life. Oceania comprises Australia, New Zealand and the PICs and territories (see figure 1). The three ethnogeographic regions (Melanesia, Micronesia and Polynesia) form the PICs. Of these, 13 are sovereign nations, while others maintain unique political associations with France, New Zealand and the USA. Figure 1 Map of Oceania (Source: map-oceania-05.gif (720×410) (globalsecurity.org). The self-governing nations have almost 13 million people but only about 2.7 million live on the smaller islands.3 They are classified as low-income and middle-income countries.3 These include the Federated States of Micronesia, Fiji, Kiribati, the Republic of the Marshall Islands (RMI), Nauru, Papua New Guinea, Samoa, the Solomon Islands, Tonga, Tuvalu and Vanuatu. Each country boasts a unique blend of culture, tradition, history and political systems. As Earth becomes warmer due to climate change, sea levels rise via two main mechanisms: expanding heated seawater and melting ice sheets and glaciers.2 Because some PICs are low-lying atolls, they face the potential existential threat of vanishing underwater with rising sea levels. The countries with the most significant threat of ‘sinking’ first are Tuvalu, Kiribati and the Republic of the Marshall Islands. Their highest elevations vary from atoll to atoll, but, generally, they are mostly under 5 m above sea level. The only bridge, which is the highest peak (<10 m above sea level) in Majuro, Republic of the …
尽管太平洋岛国对全球温室气体排放的贡献微乎其微,1 但它们却处于气候变 化影响的最前沿。2 它们的高度脆弱性源于它们分散在广阔的太平洋上的地理位 置,这使它们被大片水域所包围。这种独特的地理位置使这些岛屿社区面临与气候有关的威胁,包括海平面上升、海岸线侵蚀、海洋酸化、生物多样性丧失、粮食和水不安全以及极端天气事件,危及它们的生存和生活方式。大洋洲包括澳大利亚、新西兰、太平洋岛屿国家和领土(见图 1)。三个民族地理区域(美拉尼西亚、密克罗尼西亚和波利尼西亚)构成太平洋岛屿国家。其中 13 个是主权国家,其他则与法国、新西兰和美国保持独特的政治联系。图 1 大洋洲地图(来源:map-oceania-05.gif (720×410) (globalsecurity.org).3 这些国家包括密克罗尼西亚联邦、斐济、基里巴斯、马绍尔群岛共和国(RMI)、瑙鲁、巴布亚新几内亚、萨摩亚、所罗门群岛、汤加、图瓦卢和瓦努阿图。每个国家都拥有独特的文化、传统、历史和政治制度。随着气候变化导致地球变暖,海平面会通过两个主要机制上升:受热海水膨胀以及冰原和冰川融化。2 由于一些太平洋岛屿国家是低洼环礁,它们面临着随着海平面上升而消失在水下的潜在生存威胁。首先面临 "沉没 "威胁最大的国家是图瓦卢、基里巴斯和马绍尔群岛共和国。它们的最高海拔因环礁而异,但一般都在海平面 5 米以下。马绍尔群岛共和国马朱罗的最高峰(海拔<10 米)只有一座桥。
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引用次数: 0
Perforation of the fourth duodenal segment and peritonitis caused by a bezoar 牛粪石引起的第四段十二指肠穿孔和腹膜炎
IF 2.6 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-10 DOI: 10.1136/flgastro-2024-102739
Baptiste Massart, Chieh-Wen Lai, Kian-Hwee Chong, Jia-Hui Chen
A 43-year-old woman presented with 1 day of epigastric pain and a developing fever. She was tachycardic and febrile. Physical examination showed rebound tenderness on the left upper quadrant with decreased bowel sounds. CT of the abdomen revealed duodenal perforation surrounding a mass of unknown nature (figure 1). An oesophagogastroduodenoscopy showed a phytobezoar unusually located in the fourth duodenal segment (figure 2). A bezoar is a rare cause of small bowel perforation that most frequently occurs in …
一名 43 岁的妇女因上腹疼痛 1 天和发烧就诊。她心动过速,发热。体格检查显示左上腹有反跳痛,肠鸣音减弱。腹部 CT 显示十二指肠穿孔,周围有一个性质不明的肿块(图 1)。食管胃十二指肠镜检查显示,位于第四段十二指肠内的植物牛粪状肿块异常增大(图 2)。牛粪动物是一种罕见的小肠穿孔病因,最常发生在...
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引用次数: 0
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Frontline Gastroenterology
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