Introduction: Achieving optimal hepatic enhancement in contrast-enhanced computed tomography (CECT) is crucial for accurate diagnosis but is influenced by patient-specific factors. Fixed-dose contrast protocols often result in variability, particularly in individuals with extreme body sizes (e.g., obese patients with BMI >30 kg/m2 or very low body weight). Body size parameters: total body weight (TBW), lean body weight (LBW), body surface area (BSA), and body mass index (BMI) have been proposed to optimize dosing, yet no consensus exists.
Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. PubMed, Web of Science, Scopus, and Embase were searched (2000-2025) for studies evaluating the correlation between body parameters and hepatic enhancement during the portal venous phase in adults undergoing abdominal CECT. Correlation coefficients were extracted and pooled using a random-effects model, with heterogeneity assessed via I2 statistics.
Results: Seven studies were included in the meta-analysis. Pooled correlations revealed significant negative associations for TBW (r = -0.604, p < 0.001), BSA (r = -0.647, p < 0.001), and BMI (r = -0.466, p < 0.001). LBW showed a non-significant association (r = -0.379, p = 0.269). Heterogeneity was high for all parameters (I2 = 72.7-99 %). BSA and TBW consistently demonstrated the strongest correlations, while LBW results varied due to methodological differences.
Conclusion: Both TBW and BSA are strong predictors of hepatic enhancement, with BSA offering greater physiological relevance. LBW, while theoretically optimal, requires standardized measurement methods.
Implications for practice: Weight- or BSA-based dosing should be considered over fixed-dose protocols to achieve consistent hepatic enhancement. Incorporating standardized LBW estimation may further improve image quality and patient safety. Future research should focus on methodological consistency and diverse population validation.
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