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Biological Correlates of Dissociative Disorders: A Systematic Review on Biomarkers and Trauma Connections. 分离性障碍的生物学相关性:关于生物标志物和创伤关联的系统性综述》。
IF 2.3 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-04-07 DOI: 10.1080/15299732.2025.2481031
Ivano Caselli, Marta Ielmini, Giulia Gastaldello, Alessandro Bellini, Camilla Callegari

Pathological dissociation is characterized by disruptions in consciousness, memory, identity, perception, and affect, often linked to trauma and observed across various psychiatric conditions. Previous reviews do not fully cover key biological correlates used as biomarkers and do not clearly define the trauma-dissociation link. Therefore, this systematic review gives an overview of the studies on biomarkers research of the most relevant findings in associations between dissociative disorders and biological correlates. Additionally, it seeks to explore potential links between specific trauma types and recurrent biomarkers. A total of 123 studies were included, highlighting the role of increased prefrontal cortex activation and reduced hippocampal volume as potential biomarkers for pathological dissociation. Altered connectivity in the limbic system, frequently tied to childhood trauma, further underscores the neurobiological basis of dissociative symptoms. Biochemical and genetic studies, while promising, present inconsistent results and require further validation. This review underscores the importance of identifying reliable biomarkers to improve diagnostic accuracy, inform personalized treatment strategies, and monitor therapeutic responses. Future research should aim to unify methodologies and explore novel approaches to enhance clinical applications.

病理性解离的特征是意识、记忆、身份、感知和情感的混乱,通常与创伤有关,并在各种精神疾病中均可观察到。以往的综述并未完全涵盖用作生物标志物的关键生物学相关因素,也未明确界定创伤与解离之间的联系。因此,本系统性综述概述了有关解离障碍与生物相关性之间关联的生物标志物研究的最相关发现。此外,它还试图探讨特定创伤类型与复发性生物标志物之间的潜在联系。本研究共收录了 123 项研究,其中突出强调了前额叶皮层激活增加和海马体积缩小作为病理性解离的潜在生物标志物的作用。边缘系统连接性的改变往往与童年创伤有关,这进一步强调了解离症状的神经生物学基础。生化和遗传研究虽然前景广阔,但结果并不一致,需要进一步验证。本综述强调了确定可靠生物标志物的重要性,以提高诊断的准确性,为个性化治疗策略提供依据,并监测治疗反应。未来的研究应以统一方法论和探索新方法为目标,以加强临床应用。
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引用次数: 0
How-To Study Dissociative Symptoms in a Broad Range of Mental Disorders: A Methodological Primer. 如何研究各种精神障碍的分离症状:方法论入门》。
IF 2.3 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-04-07 DOI: 10.1080/15299732.2025.2481474
Sarah K Danböck, Yoki L Mertens, Patricia Kulla, Katja I Seitz, Inga Schalinski

Dissociative symptoms constitute a transdiagnostic phenomenon not only characterizing dissociative disorders but also occurring across a broad range of other mental disorders such as posttraumatic stress disorder or borderline personality disorder. In the latter disorders, dissociative symptoms such as depersonalization, derealization, or gaps in awareness significantly burden patients' wellbeing and functioning. Many efforts have been undertaken to better understand these debilitating symptoms. However, empirical findings have not yet converged in many areas (e.g., considering neurobiological correlates or effects of dissociative psychopathology on treatment outcome), which might partially be due to the heterogeneity and limitations of employed methodology. Here, we critically review the current state-of-the-art methodology in dissociation research, comparing methods to assess dissociative symptoms, provoke dissociative symptoms in the laboratory, select the participant sample, and consider critical sample characteristics. Discussing the informative value and limits of various standard and novel methodological approaches, we aim to provide information and nuanced guidance for future research. By these means, we aim to raise and harmonize standards in dissociation research and enable researchers of all career stages to enter, navigate, and make a significant and lasting contribution to research on dissociative symptoms in a broad range of mental disorders, ultimately contributing to a better understanding of dissociative psychopathology.

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引用次数: 0
A Prospective Examination of Sexual Assault Labeling and Posttraumatic Stress: Does Trust in the Perpetrator Make a Difference?
IF 2.3 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-04-02 DOI: 10.1080/15299732.2025.2481476
Rebecca L Howard Valdivia, Madison E Edwards, Harper R Jones, Shaina A Kumar, Anna E Jaffe

How survivors label a nonconsensual sexual experience (i.e. sexual assault labeling) has been linked to posttraumatic stress symptoms (PTSS), but past cross-sectional research has been unable to determine the direction of this relation. To inform support approaches following sexual assault, we examined how sexual assault labeling and PTSS were related over time. We also examined the contextual factor of pre-assault trust in the perpetrator on these relations. Participants were 609 college student sexual assault survivors (aged 19 to 25) who completed an initial online survey and were invited to a follow-up survey 1 to 2 months later. When controlling for individual and assault-specific covariates, results of a cross-lagged panel model indicated that greater sexual assault labeling was associated with subsequent elevations in PTSS, and heightened PTSS was associated with subsequent increases in sexual assault labeling. Moreover, pre-assault trust in the perpetrator was a significant moderator. Specifically, participants who reported greater (vs. weaker) pre-assault trust demonstrated more stability in labeling between timepoints, stronger associations between labeling and later PTSS, and weaker relations between PTSS and later labeling. Findings supported a prospective, bidirectional relation between sexual assault labeling and PTSS and underscored the importance of pre-assault trust in the perpetrator, which may make such labeling uniquely distressing. Informal and formal support providers should be prepared for the distress that may be associated with using a sexual assault label, particularly when survivors trusted the perpetrator before the assault.

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引用次数: 0
The Internal Moderation Questionnaire (IMQ): A Novel Measure of Self-Regulation.
IF 2.3 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-24 DOI: 10.1080/15299732.2025.2481030
Görkem Ayas, Vedat Sar, Sevin Hun Senol, Tuğba Türk-Kurtça

Internal moderation is theorized as a regulatory mental mechanism that mitigates the impact of incongruent stimuli by generating a calibrated internal response. The aim of this study was to develop a standardized self-report instrument designed to measure an individual's current level of internal moderation. An initial version of the Internal Moderation Questionnaire (IMQ), the Dissociative Experiences Scale (DES), the Difficulties in Emotion Regulation Scale (DERS), and the Childhood Trauma Questionnaire (CTQ-33) were applied to 329 college students. A test-retest evaluation was conducted on a separate group of 50 college students with two administrations in a 7-day interval. Reliability and validity analyses yielded a 24-item final version of the questionnaire with excellent internal consistency. The IMQ demonstrated strong to moderate correlations with DES and DERS total scores, while its association with CTQ-33 total scores was rather minimal. In principal components analysis, a three-factor solution yielded the "dual," "on," and "off" modes of internal moderation. Higher scores on these modes, and in particular the dual mode score, which represented the largest proportion of the total variance, and the sum of the on and off scores were associated with higher disturbance overall, while the difference between them was not. This preliminary study supported the validity and reliability of the IMQ in a self-referred non-clinical sample of young adults. Further studies on larger, diverse, and clinical samples should identify its significance in detection of prodromal risk syndromes, assessment of treatment response, forensic evaluations, prediction of self-destruction and impulsivity, and decision-making in uncertain conditions.

根据理论,内部节制是一种调节心理机制,它通过产生校准的内部反应来减轻不协调刺激的影响。本研究旨在开发一种标准化的自我报告工具,用于测量个体当前的内部调节水平。内部调节问卷(IMQ)的初始版本、分离体验量表(DES)、情绪调节困难量表(DERS)和童年创伤问卷(CTQ-33)被应用于 329 名大学生。对另一组 50 名大学生进行了重测评估,在 7 天内进行了两次施测。信度和效度分析结果表明,24 个项目的问卷最终版本具有极佳的内部一致性。IMQ与DES和DERS的总分有很强到中等程度的相关性,而与CTQ-33总分的相关性则很小。在主成分分析中,三因素解法得出了内部调节的 "双"、"开 "和 "关 "模式。这些模式的得分越高,尤其是占总方差比例最大的 "双重模式 "得分,以及 "开启 "和 "关闭 "得分之和,与总体干扰程度越高相关,而它们之间的差异则与之无关。这项初步研究证实了 IMQ 在自我推荐的非临床年轻成年人样本中的有效性和可靠性。对更大规模、多样化和临床样本的进一步研究应能确定 IMQ 在检测前驱危险综合征、评估治疗反应、法医评估、预测自我毁灭和冲动以及在不确定条件下做出决策等方面的意义。
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引用次数: 0
Changes in Psychological and Relationship Dimensions of Sexuality After Trauma Focused Therapy in Women with Interpersonal Child Abuse Related PTSD. 人际虐待儿童相关创伤后应激障碍女性接受创伤集中疗法后,性心理和性关系方面的变化。
IF 2.3 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-24 DOI: 10.1080/15299732.2025.2481028
Judith Weiss, Pia Bornefeld-Ettmann, Nikolaus Kleindienst, Meike Müller-Engelmann, Kathlen Priebe, Regina Steil

Women with posttraumatic stress disorder (PTSD) often report problems with sexuality. Relationship dimensions and psychological dimensions of sexuality seem to be impaired. We examined whether trauma focused therapies improve relationship and psychological dimensions of sexuality. In a randomized controlled trial that took part between 2014 and 2016 in Germany, N = 193 cisgender women with PTSD after child abuse (mean age = 36.3 years) completed the Multidimensional Sexuality Questionnaire, assessing psychological dimensions of sexuality and the Resources in Sexuality and Partnership, assessing relationship dimensions of sexuality. PTSD was assessed via Clinician Administered PTSD Scale for DSM-5. Assessments took part in the beginning and after Dialectical Behavior Therapy for PTSD or Cognitive Processing Therapy. Using hierarchical linear modeling, changes in psychological and relationship dimensions of sexuality from beginning to post treatment were assessed, also the association between PTSD symptom reduction and reduction in psychological and relationship dimensions. From beginning to post treatment, relationship dimensions of sexuality improved (p < .01; Cohen's d = .36). PTSD symptom reduction moderated this effect. The psychological dimension sexual satisfaction increased (p < .05; Cohen's d = .32), sexual anxiety (p < .001; Cohen's d = ‒.51) and sexual depression (p < .001; Cohen's d = ‒.44) decreased. PTSD symptom reduction moderated these effects. Sexual esteem and sexual motivation did not change after therapy. Our results suggest that relationship dimensions and some psychological dimensions of sexuality can improve after trauma focused therapy. Other psychological dimensions like sexual esteem might need specific therapeutic interventions to improve.

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引用次数: 0
Challenging Social Taboos in Early Caregiving - Assessing Maternal Intrusive Thoughts and Dissociative Experiences Among Arab Mothers.
IF 2.3 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-24 DOI: 10.1080/15299732.2025.2481481
Samah Mahamid, Miriam Chasson, Orit Taubman-Ben-Ari

The current investigation consists of two studies aimed at validating an Arabic version of the Maternal Disintegrative Responses Scale (A-MDRS), designed to evaluate maternal intrusive thoughts and dissociative experiences during early caregiving. The participants consisted of Arab mothers in Israel within 12 months post-childbirth. Study 1 (n = 243) assessed the factorial structure and reliability of the scale, and its correlation with maternal background variables. Study 2 (n = 195) further explored its factorial structure and reliability, as well as its construct validity, by examining associations with postpartum depression, maternal role satisfaction, and psychological flexibility. Confirmatory factor analyses in both studies supported a two-factor solution, demonstrating good reliability. In addition, Study 2 revealed a positive correlation between the A-MDRS factors and postnatal depression, and a negative association with maternal role satisfaction and psychological flexibility. The findings endorse the A-MDRS's value in identifying maternal disintegrative responses during the postpartum period, affirming its factorial structure and reliability.

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引用次数: 0
Influence of Childhood Maltreatment on Schizoid Personality Pathology.
IF 2.3 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-22 DOI: 10.1080/15299732.2025.2481034
Sydney N Stone, Kaleigh M Newcomb, Matthew M Yalch

Schizoid personality disorder (SPD) is among the most enduring forms of personality pathology. Research suggests that one factor associated with schizoid pathology is childhood maltreatment, although it is unclear which specific experiences of childhood maltreatment may be most impactful. In this study, we examined associations between different experiences of childhood maltreatment (e.g. physical, emotional, and sexual abuse, and physical and emotional neglect) and schizoid pathology in a sample of men and women recruited online (N = 327) using a Bayesian approach to structural equation modeling. Results suggest that emotional neglect had the strongest association with schizoid pathology over and above other forms of maltreatment and other traumatic life events. Findings further indicate that emotional and physical neglect as well as other negative life events are associated with schizoid pathology in men but only emotional abuse is associated with schizoid pathology for women. These findings provide support for the influence of childhood maltreatment on schizoid pathology and have implications for future research and clinical intervention.

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引用次数: 0
Applying an Institutional Betrayal Lens to Caregiver Perceptions of Child Maltreatment Investigations.
IF 2.3 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-19 DOI: 10.1080/15299732.2025.2481029
Adi Rosenthal, Maria-Ernestina Christl, Naomi Wright, Julie Olomi, Julia Dmitrieva, Anne P DePrince

Caregivers involved in child maltreatment investigations depend on the child protection system to safeguard their child from harm. Given this dependence, Institutional Betrayal (IB) may be a useful framework to characterize caregivers' experiences with child protection. However, research has yet to examine IB in the child protection system. The current study sought to understand whether caregiver report experiences that are consistent with key characteristics of IB identified in other systems, such as sexual assault investigations. Caregivers of children involved in child maltreatment investigations (n = 32) were asked open-ended questions. Through content analysis, we identified examples and counterexamples of four key characteristics of IB: exclusion, discrimination, invalidation, and inaction. Caregivers described exclusion from the process (e.g. through uncertainty about their role), discrimination (e.g. through perceptions that socioeconomic factors influenced investigation outcomes), invalidation (e.g. through victim-blaming), and inaction on the part of system personnel (e.g. through lack of follow-through on promised steps). Participants also provided counterexamples to each characteristic. All participants highlighted the importance of communication in experiences of IB. Utilizing caregiver feedback to address IB is crucial for enhancing caregiver engagement and supporting the child protection system's goals of promoting child and family well-being.

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引用次数: 0
Posttraumatic Stress Disorder and Dissociation in a Clinical Sample of Refugees in the Netherlands: Evidence for a Dissociative Subtype. 荷兰难民临床样本中的创伤后应激障碍和分离:分离亚型的证据。
IF 2.3 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2025-01-18 DOI: 10.1080/15299732.2024.2448429
Simone de la Rie, Sem Kruijt, Elena Stojimirović, Niels van der Aa, Paul A Boelen

An increasing number of studies have been investigating the co-occurrence of posttraumatic symptoms and dissociation in trauma-exposed samples. As traumatized refugees are particularly susceptible to developing posttraumatic stress disorder (PTSD), the aim of this study was to investigate the relationship between PTSD and dissociation in a traumatized refugee sample. Cross-sectional data from a clinical refugee sample (N = 526) were collected. Latent class analysis (LCA) examined different classes of PTSD, based on the Clinician Administered PTSD Scale for DSM-5 (CAPS-5) items. Subsequently, it was examined whether cumulative trauma, sexual trauma and general psychopathology predicted class membership. The LCA identified five classes. The classes were summarized as (1) "High PTSD," (2) "Moderate PTSD," (3) "High PTSD with high loss of interest," (4) "High PTSD with moderate loss of interest," and (5) "PTSD-DS." PTSD DS (10% of the sample) was characterized by high PTSD symptoms, as well as high depersonalization and derealization symptoms. The majority (61.4%) of this group has been exposed to sexual trauma. Overall endorsement of PTSD symptoms was extremely high in this clinical sample of refugees. A group evidencing the PTSD dissociative subtype was identified.

越来越多的研究一直在调查创伤暴露样本中创伤后症状和分离的共同发生。由于创伤难民特别容易发展为创伤后应激障碍(PTSD),本研究的目的是调查创伤难民样本中创伤后应激障碍与分离之间的关系。收集临床难民样本(N = 526)的横断面数据。潜在类别分析(LCA)根据DSM-5 (CAPS-5)项目的临床医生管理的PTSD量表来检查不同类别的PTSD。随后,研究人员检查了累积创伤、性创伤和一般精神病理是否能预测班级成员。LCA确定了五个类别。课程总结如下:(1)“重度创伤后应激障碍”(2)“中度创伤后应激障碍”(3)“高创伤后应激障碍伴高兴趣丧失,”(4)“重度创伤后应激障碍伴中度兴趣丧失”和(5)“PTSD-DS。”PTSD DS(10%的样本)的特征是高度PTSD症状,以及高度人格解体和现实感丧失症状。这一群体中的大多数(61.4%)曾遭受过性创伤。在这些难民的临床样本中,PTSD症状的总体认可度极高。一组证据表明PTSD分离亚型被确定。
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引用次数: 0
The Mediating Role of Emotion Regulation and Basic Psychological Needs: Association Between Childhood Trauma and Young Adults' Psychological Functioning from a Self-Determination Theory Perspective. 情绪调节与基本心理需求的中介作用:自我决定理论视角下童年创伤与青少年心理功能的关系
IF 2.3 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2024-12-03 DOI: 10.1080/15299732.2024.2429474
Asma Rashid, Jolene van der Kaap-Deeder, Mariangela Abbate, Sebastiano Costa

Numerous studies have shown the detrimental effects of childhood trauma on individuals' psychological functioning. This study examined the relation from childhood traumatic experiences to dissociation, life satisfaction, and attitude toward seeking psychological help while additionally shedding light on the possible mediating role of emotion regulation and basic psychological needs based on the framework of Self-Determination Theory (SDT). Using a cross-sectional design, data were collected from 489 Italian young adults (Mage = 23.63, SDage = 3.53, 68.7% female) through an online survey. Findings indicated positive associations between childhood trauma and emotion dysregulation, suppression, need frustration, and dissociation. In contrast, negative associations were found with emotion integration, need satisfaction, life satisfaction, and attitude toward seeking psychological help. Structural equation modeling analysis supported the hypothesized indirect associations, suggesting that childhood trauma is indirectly associated with 1) higher levels of dissociation through increased emotion dysregulation, emotion suppression, and need frustration; 2) lower life satisfaction via higher emotion dysregulation and need frustration, as well as diminished need satisfaction and emotion integration; and 3) less positive attitude toward seeking psychological help by elevated emotion suppression and reduced emotion integration. These findings validate SDT as a potent framework for understanding the nuanced pathways from childhood trauma to adult psychological functioning, providing the groundwork for intervention development and a pathway for further exploration with clinical populations.

大量研究表明,童年创伤对个体的心理功能有不利影响。本研究在自我决定理论的框架下,探讨了童年创伤经历与心理分离、生活满意度和心理求助态度的关系,并揭示了情绪调节和基本心理需求的可能中介作用。采用横断面设计,通过在线调查收集了489名意大利年轻人(年龄= 23.63,年龄= 3.53,68.7%为女性)的数据。研究结果表明,儿童创伤与情绪失调、压抑、需求挫折和分离呈正相关。情绪整合、需求满足、生活满意度和寻求心理帮助的态度呈负相关。结构方程模型分析支持了间接关联的假设,表明童年创伤与1)通过增加情绪失调、情绪抑制和需求挫折而产生的更高水平的解离间接相关;2)较高的情绪失调和需求挫折导致生活满意度降低,需求满意度和情绪整合降低;3)情绪压抑升高、情绪整合降低导致寻求心理帮助的积极态度降低。这些发现验证了SDT作为理解从童年创伤到成人心理功能的微妙途径的有力框架,为干预开发提供了基础,并为进一步探索临床人群提供了途径。
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引用次数: 0
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Journal of Trauma & Dissociation
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