Pub Date : 2024-07-24DOI: 10.2174/012210299x285895240521042601
Krishna Gupta, Masne Tejaswini, M. Umekar
Fungi are widely acknowledged as one of the most diverse and ecologically significant organisms with substantial economic importance on Earth. Edible and medicinal mushrooms have been recognized by human societies since ancient times, serving not only as valuable sources of nourishment but also as medicinal agents. The primary objective of this study is to explore the fruiting bodies of edible mushrooms and assess their capacity to serve as reservoirs of bioactive metabolites with pharmaceutical potential. The extensive analysis conducted aimed to elucidate the significant potential of these medicinal mushrooms, comparable to that of plants, in producing valuable bioactive compounds, thereby positioning them as abundant reservoirs for pharmaceutical compounds. Fungi produce many different bioactive compounds of different molecular weights, including lectins, lipids, peptidoglycans, phenols, polyketides, polysaccharides, proteins, polysaccharide-protein/peptide complexes, ribosomal and non-ribosomal peptides, steroids, terpenoids, and others. These compounds have more than 130 different therapeutic properties, such as analgesic, antimicrobial, antifungal, anti-inflammatory, anti-plaque, antiviral, cytotoxic, hepatoprotective, cholesterol-lowering, blood-sugar-lowering, blood-pressure-lowering, immune system, response system modulation, immune suppression, cell growth stimulation or regeneration, and more. Several bioactive polysaccharides or polysaccharide-protein complexes identified in these medicinal mushrooms seem to augment both innate and cell-mediated immune responses. Furthermore, these compounds display anti-tumor properties in both animal models and humans.
{"title":"Medicinal Value of Mushroom: A Deeper Insight","authors":"Krishna Gupta, Masne Tejaswini, M. Umekar","doi":"10.2174/012210299x285895240521042601","DOIUrl":"https://doi.org/10.2174/012210299x285895240521042601","url":null,"abstract":"\u0000\u0000Fungi are widely acknowledged as one of the most diverse and ecologically significant organisms with substantial economic importance on Earth.\u0000Edible and medicinal mushrooms have been recognized by human societies since ancient times, serving not only as valuable sources of\u0000nourishment but also as medicinal agents. The primary objective of this study is to explore the fruiting bodies of edible mushrooms and assess their\u0000capacity to serve as reservoirs of bioactive metabolites with pharmaceutical potential. The extensive analysis conducted aimed to elucidate the\u0000significant potential of these medicinal mushrooms, comparable to that of plants, in producing valuable bioactive compounds, thereby positioning\u0000them as abundant reservoirs for pharmaceutical compounds.\u0000\u0000\u0000\u0000Fungi produce many different bioactive compounds of different molecular weights, including lectins, lipids, peptidoglycans, phenols, polyketides,\u0000polysaccharides, proteins, polysaccharide-protein/peptide complexes, ribosomal and non-ribosomal peptides, steroids, terpenoids, and others.\u0000These compounds have more than 130 different therapeutic properties, such as analgesic, antimicrobial, antifungal, anti-inflammatory, anti-plaque,\u0000antiviral, cytotoxic, hepatoprotective, cholesterol-lowering, blood-sugar-lowering, blood-pressure-lowering, immune system, response system\u0000modulation, immune suppression, cell growth stimulation or regeneration, and more. Several bioactive polysaccharides or polysaccharide-protein\u0000complexes identified in these medicinal mushrooms seem to augment both innate and cell-mediated immune responses. Furthermore, these\u0000compounds display anti-tumor properties in both animal models and humans.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"48 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141808260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FDA Approval of Zituvio for Type 2 Diabetes","authors":"Abishek V, Muskan, Saurabh Srivastava, Pbn Prasad, Sandeep Kumar","doi":"10.2174/012210299x286824240722042737","DOIUrl":"https://doi.org/10.2174/012210299x286824240722042737","url":null,"abstract":"<jats:sec>\u0000<jats:title/>\u0000<jats:p/>\u0000</jats:sec>","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"50 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141809682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.2174/012210299x306942240711105604
S. Latthe, Akshay R. Jundle, Prashant Yadav, Chandrakant Patil, U. Mote, Rajaram S. Sutar, Shanhu Liu
To Fabricate the superhydrophobic Stainless Steel (SS) mesh using Trimethylchlorosilane (TMCS) through a Chemical Vapor Deposition (CVD) method for the oil-water mixture separation The frequent oil spills have a devastating impact on marine ecosystems and the environment. The porous materials with superhydrophobic properties have been created to separate oil and water effectively. Due to their ability to effectively separate oil and water, superhydrophobic coatings have gained significant attention. The cleaned stainless-steel mesh was put on a stand and covered with a glass container. Within the container, 50 mL of hexane, which contained 1 mL of TMCS, was added. The mesh was then left for 3 h to undergo the CVD process The silane content with low surface energy creates a highly rough structure on the mesh surface. The optimal mesh coating is superhydrophobic, having a strong affinity to oil and a water contact angle of 162 ± 2°. The coated mesh has shown a separation efficiency of over 97.8% for different oil-water mixtures. The coatings sustain their superhydrophobicity up to 30 tape peels and 40 times sandpaper abrasion, indicating good mechanical durability. The study concludes that the S-3 sample is mechanically stable and can withstand various tests such as adhesive tape peeling, sandpaper abrasion, bending, folding, and twisting. It efficiently separates oil and water mixtures on a large scale with high efficacy
{"title":"Superhydrophobic Stainless Steel Mesh through Chemical Vapour Deposition of\u0000TMCS for Effective Oil-Water Separation","authors":"S. Latthe, Akshay R. Jundle, Prashant Yadav, Chandrakant Patil, U. Mote, Rajaram S. Sutar, Shanhu Liu","doi":"10.2174/012210299x306942240711105604","DOIUrl":"https://doi.org/10.2174/012210299x306942240711105604","url":null,"abstract":"\u0000\u0000To Fabricate the superhydrophobic Stainless Steel (SS) mesh using Trimethylchlorosilane (TMCS) through a Chemical Vapor Deposition (CVD)\u0000method for the oil-water mixture separation\u0000\u0000\u0000\u0000The frequent oil spills have a devastating impact on marine ecosystems and the environment. The porous materials with superhydrophobic\u0000properties have been created to separate oil and water effectively. Due to their ability to effectively separate oil and water, superhydrophobic\u0000coatings have gained significant attention.\u0000\u0000\u0000\u0000The cleaned stainless-steel mesh was put on a stand and covered with a glass container. Within the container, 50 mL of hexane, which contained 1\u0000mL of TMCS, was added. The mesh was then left for 3 h to undergo the CVD process\u0000\u0000\u0000\u0000The silane content with low surface energy creates a highly rough structure on the mesh surface. The optimal mesh coating is superhydrophobic,\u0000having a strong affinity to oil and a water contact angle of 162 ± 2°. The coated mesh has shown a separation efficiency of over 97.8% for different\u0000oil-water mixtures. The coatings sustain their superhydrophobicity up to 30 tape peels and 40 times sandpaper abrasion, indicating good\u0000mechanical durability.\u0000\u0000\u0000\u0000The study concludes that the S-3 sample is mechanically stable and can withstand various tests such as adhesive tape peeling, sandpaper abrasion,\u0000bending, folding, and twisting. It efficiently separates oil and water mixtures on a large scale with high efficacy\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"34 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.2174/012210299x318258240710090746
Krisangi Bordoloi, Jyotishma Baruah, Bibekananda Gogoi, Pankaj Das
Oxidation of alcohols in an oxidant-free condition, commonly known as the acceptorless dehydrogenation (AD) reaction, has recently emerged as one of the widely used processes in synthetic organic chemistry. Alcohol acts as an excellent chemical precursor that produces a variety of dehydrogenated value-added products such as carbonyls, acids, acetals, and several coupling products, followed by the concomitant evolution of molecular hydrogen gas. AD reaction of alcohol, therefore, can be considered as a vital reaction for the hydrogen economy using alcohols as a liquid hydrogen carrier. Over the past decade, the growing importance of AD reactions has set the way for the continuous development of various homogeneous and heterogeneous catalytic systems. With the advantage of reusability and recyclability, heterogeneous catalysts have now become more promising and significant in the catalytic domain. This review aims to make an overview of the transition metal-based heterogeneous catalytic system of acceptorless alcohol dehydrogenation reaction reported till December, 2023.
醇在无氧化剂条件下的氧化反应，通常称为无受体脱氢反应（AD），最近已成为合成有机化学中广泛使用的工艺之一。酒精是一种极好的化学前体，可产生多种脱氢增值产品，如羰基、酸、乙醛和多种偶联产物，并随之产生分子氢气。因此，酒精的 AD 反应可被视为利用酒精作为液态氢载体实现氢经济的重要反应。在过去的十年中，AD 反应的重要性与日俱增，为各种均相和异相催化系统的不断发展开辟了道路。由于具有可重复使用和可回收的优点，异相催化剂目前在催化领域变得更有前景和意义。本综述旨在概述截至 2023 年 12 月所报道的无受体醇脱氢反应的过渡金属基异相催化体系。
{"title":"Recent Advances in Heterogeneously Catalyzed Acceptorless Dehydrogenation\u0000of Alcohols to Carbonyl Derivatives and N-heterocyclic Compounds","authors":"Krisangi Bordoloi, Jyotishma Baruah, Bibekananda Gogoi, Pankaj Das","doi":"10.2174/012210299x318258240710090746","DOIUrl":"https://doi.org/10.2174/012210299x318258240710090746","url":null,"abstract":"\u0000\u0000Oxidation of alcohols in an oxidant-free condition, commonly known as the acceptorless dehydrogenation (AD) reaction, has recently emerged as\u0000one of the widely used processes in synthetic organic chemistry. Alcohol acts as an excellent chemical precursor that produces a variety of\u0000dehydrogenated value-added products such as carbonyls, acids, acetals, and several coupling products, followed by the concomitant evolution of\u0000molecular hydrogen gas. AD reaction of alcohol, therefore, can be considered as a vital reaction for the hydrogen economy using alcohols as a\u0000liquid hydrogen carrier. Over the past decade, the growing importance of AD reactions has set the way for the continuous development of various\u0000homogeneous and heterogeneous catalytic systems. With the advantage of reusability and recyclability, heterogeneous catalysts have now become\u0000more promising and significant in the catalytic domain. This review aims to make an overview of the transition metal-based heterogeneous\u0000catalytic system of acceptorless alcohol dehydrogenation reaction reported till December, 2023.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"31 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.2174/012210299x320402240715065917
Amit Kumar Yadav, Suruchi Aggarwal
The technological advances in mass spectrometry and associated computational tools have enabled the development of proteome atlases and comprehensive catalogs of proteome snapshots that have gradually transformed biomedical research. These proteome catalogs in specific biological contexts, which focused initially on model organisms, have now expanded their scope to encompass diverse organisms, tissues, and experimental conditions. These atlases, such as the Human Protein Atlas (HPA), Peptide Atlas, and Global Proteome Machine Database (GPMDB), etc. provide invaluable insights into protein expression, subcellular localization, interactions, modifications, and functions. They aid in understanding biological processes, identifying disease biomarkers, and discovering novel therapeutic targets. Despite their potential, proteome atlases face challenges like data completeness, integration with other omics data, and ethical considerations. Addressing these challenges is vital for further progress. Proteome atlases serve as indispensable resources, driving biomedical discovery and innovation.
{"title":"What are Proteome Atlases good for?","authors":"Amit Kumar Yadav, Suruchi Aggarwal","doi":"10.2174/012210299x320402240715065917","DOIUrl":"https://doi.org/10.2174/012210299x320402240715065917","url":null,"abstract":"\u0000\u0000The technological advances in mass spectrometry and associated computational tools have enabled the development of proteome atlases and\u0000comprehensive catalogs of proteome snapshots that have gradually transformed biomedical research. These proteome catalogs in specific\u0000biological contexts, which focused initially on model organisms, have now expanded their scope to encompass diverse organisms, tissues, and\u0000experimental conditions. These atlases, such as the Human Protein Atlas (HPA), Peptide Atlas, and Global Proteome Machine Database\u0000(GPMDB), etc. provide invaluable insights into protein expression, subcellular localization, interactions, modifications, and functions. They aid in\u0000understanding biological processes, identifying disease biomarkers, and discovering novel therapeutic targets. Despite their potential, proteome\u0000atlases face challenges like data completeness, integration with other omics data, and ethical considerations. Addressing these challenges is vital\u0000for further progress. Proteome atlases serve as indispensable resources, driving biomedical discovery and innovation.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"36 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-14DOI: 10.2174/012210299x255340231115095951
Ishu Garg, Raj Kumari, Meenakshi Sharma
Concerning the past few years in terms of health and nature, the globe has witnessed an upsurge in the use of nutraceuticals and nutritional and natural products in therapeutics. The major reason for this step is the conventional pharmacological treatment using synthetic drugs that do not meet the status of health and therapeutic requirements for various pathological conditions. Nutraceuticals promise prominent health and therapeutic benefits with no adverse or side effects, providing extra health benefits besides their action in any defined pathological condition. Nutraceuticals are extensive biological therapies that include herbs, vitamins, fatty acids, prebiotics, and probiotics used to promote and maintain health to prevent and cure pathological conditions, malignant processes, syndromes, and symptoms. Nutraceuticals have multidirectional therapeutic benefits and are claimed to be effective products in aiding human health. The addition of omega-3 for the treatment of mental and mood disorders was found to have safer, more valuable, and better therapeutic results in comparison to the use of synthetic drugs. Omega-3 is available in the regular diet through soybeans, walnuts, codfish, and salmon fish, and its constituents have been found to play a promising role in brain development, including brain aging and neurodegenerative disorders, in the pathology of mental and mood disorders, and treatment of the same. Supplementation with Omega-3 PUFA provides a promising effect in better brain development, treatment, prevention and cure of mental and mood disorders. This review endeavours to display and assert the clinical relevance of omega-3 PUFA in brain development, pathology, and treatment of mental and mood disorders.
{"title":"Role of Omega-3PUFA: A Nutraceutical for Brain Functioning and Treatment\u0000of Mental Disorders","authors":"Ishu Garg, Raj Kumari, Meenakshi Sharma","doi":"10.2174/012210299x255340231115095951","DOIUrl":"https://doi.org/10.2174/012210299x255340231115095951","url":null,"abstract":"\u0000\u0000Concerning the past few years in terms of health and nature, the globe has witnessed an upsurge in the use of nutraceuticals and nutritional and\u0000natural products in therapeutics. The major reason for this step is the conventional pharmacological treatment using synthetic drugs that do not\u0000meet the status of health and therapeutic requirements for various pathological conditions. Nutraceuticals promise prominent health and therapeutic\u0000benefits with no adverse or side effects, providing extra health benefits besides their action in any defined pathological condition. Nutraceuticals\u0000are extensive biological therapies that include herbs, vitamins, fatty acids, prebiotics, and probiotics used to promote and maintain health to prevent\u0000and cure pathological conditions, malignant processes, syndromes, and symptoms. Nutraceuticals have multidirectional therapeutic benefits and are\u0000claimed to be effective products in aiding human health. The addition of omega-3 for the treatment of mental and mood disorders was found to\u0000have safer, more valuable, and better therapeutic results in comparison to the use of synthetic drugs. Omega-3 is available in the regular diet\u0000through soybeans, walnuts, codfish, and salmon fish, and its constituents have been found to play a promising role in brain development, including\u0000brain aging and neurodegenerative disorders, in the pathology of mental and mood disorders, and treatment of the same. Supplementation with\u0000Omega-3 PUFA provides a promising effect in better brain development, treatment, prevention and cure of mental and mood disorders. This\u0000review endeavours to display and assert the clinical relevance of omega-3 PUFA in brain development, pathology, and treatment of mental and\u0000mood disorders.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"22 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138972770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This report discusses two medicinal plants, namely Exallage auricularia (L.) Bremek from Rubiaceae family and Gomphostemma ovatum Wall from Lamiaceae family from Ultapani Reserve Forest of Bodoland Territorial Region (BTR) of Assam, India, are recorded, described, and identified based on their morphological characters, taxonomical notes, phenology, and field photos along with map of distribution. The local Bodo-trib of Assam used leaf paste of E. auricularia to cure jaundice and piles and G. ovatum for treatment of different ailments like flu, cough, cold, skin irritations, symptoms of indigestion, jaundice, etc. Inflorescence - verticillaster inflorescence in leaf axil, 3 to many flowers, 2 to 5 cm long. Flowers are born in opposite cymes, subtended by bracts, easily indistinguishable from leaves, and the arrangement of flowers is congested or lax. Bracts - leaf-like small cluster, subtending cyme, involucral bracts, stellate hairs, large bracteoles exceeding the calyx. G. ovatum is a perennial plant that can grow up to around 1.5 m tall and has tuber-like roots with infrequent node-level rooting.
本报告讨论了两种药用植物，即茜草科的 Exallage auricularia (L.) Bremek 和来自印度阿萨姆邦 Bodoland Territorial Region (BTR) Ultapani Reserve Forest 的 Lamiaceae 科的 Gomphostemma ovatum Wallfrom，根据其形态特征、分类注释、物候学和野外照片以及分布图对这两种植物进行了记录、描述和鉴定。阿萨姆邦当地的博多部落用 E. auricularia 的叶膏治疗黄疸和痔疮，用 G. ovatum 治疗不同的疾病，如流感、咳嗽、感冒、皮肤过敏、消化不良症状、黄疸等。花为对生聚伞花序，被苞片包着，很容易与叶区分开，花的排列密集或疏松。苞片--叶状小簇生，对着聚伞花序，总苞片，星状毛，大的小苞片超过花萼。卵形聚伞花序（G. ovatum）是多年生植物，可长到 1.5 米左右高，具有块茎状根，很少有节上生根。
{"title":"New Record of Two Medicinal Plants, Exallage Auricularia and Gomphostemma\u0000Ovatum, from Ultapani Reserve Forest, Northeast India","authors":"Gouri Rani Baglary, Twinkle Basumatary, Anuck Islary, Santosh Kumar","doi":"10.2174/012210299x277042231210055856","DOIUrl":"https://doi.org/10.2174/012210299x277042231210055856","url":null,"abstract":"\u0000\u0000This report discusses two medicinal plants, namely Exallage auricularia (L.) Bremek from Rubiaceae family and Gomphostemma ovatum Wall\u0000from Lamiaceae family from Ultapani Reserve Forest of Bodoland Territorial Region (BTR) of Assam, India, are recorded, described, and\u0000identified based on their morphological characters, taxonomical notes, phenology, and field photos along with map of distribution.\u0000\u0000\u0000\u0000The local Bodo-trib of Assam used leaf paste of E. auricularia to cure jaundice and piles and G. ovatum for treatment of different ailments like flu,\u0000cough, cold, skin irritations, symptoms of indigestion, jaundice, etc.\u0000\u0000\u0000\u0000Inflorescence - verticillaster inflorescence in leaf axil, 3 to many flowers, 2 to 5 cm long. Flowers are born in opposite cymes, subtended by bracts,\u0000easily indistinguishable from leaves, and the arrangement of flowers is congested or lax. Bracts - leaf-like small cluster, subtending cyme,\u0000involucral bracts, stellate hairs, large bracteoles exceeding the calyx.\u0000\u0000\u0000\u0000G. ovatum is a perennial plant that can grow up to around 1.5 m tall and has tuber-like roots with infrequent node-level rooting.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"19 2‐3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138972323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13DOI: 10.2174/012210299x244559231116105210
Rakesh Devidas Amrutkar, Kishor S. Jain
The present study reveals the 2D, 3D-QSAR analysis of Thieno[3,2-d]pyrimidine to express the biological activity against Cholesterol, structurally different ligands can fit the common receptor site, and Pharmacophore models well describe safety considerations of the said chemical entities The organic exercises of the atoms were changed over into log IC50. The measurably huge of 2D-QSAR and 3D QSAR models are r2 = 0 .9762, q2 = 0.9379 and internal (q2 = 0.8837) and external (predictive r2 = 0.9162) respectively. 2D QSAR studies revealed that the Positive coefficient value of Quadrupole2 and Negative coefficient value of T_2_Cl_7 descriptors were major contributing descriptors. The 3D QSAR models indicate that steric and electrostatic effects primarily determine binding affinities. From the best model obtained from the QSAR analyses, some newer compounds of the same series were developed, having better activity than the earlier compounds that have been reported.
{"title":"“2D, 3D QSAR and Pharmacophore Identification of Thieno[3,2-d]pyrimidines\u0000as Cholesterol inhibitors.”","authors":"Rakesh Devidas Amrutkar, Kishor S. Jain","doi":"10.2174/012210299x244559231116105210","DOIUrl":"https://doi.org/10.2174/012210299x244559231116105210","url":null,"abstract":"\u0000\u0000The present study reveals the 2D, 3D-QSAR analysis of Thieno[3,2-d]pyrimidine to express the biological activity against Cholesterol, structurally\u0000different ligands can fit the common receptor site, and Pharmacophore models well describe safety considerations of the said chemical entities\u0000\u0000\u0000\u0000The organic exercises of the atoms were changed over into log IC50. The measurably huge of 2D-QSAR and 3D QSAR models are r2 = 0 .9762,\u0000q2 = 0.9379 and internal (q2 = 0.8837) and external (predictive r2 = 0.9162) respectively. 2D QSAR studies revealed that the Positive coefficient\u0000value of Quadrupole2 and Negative coefficient value of T_2_Cl_7 descriptors were major contributing descriptors.\u0000\u0000\u0000\u0000The 3D QSAR models indicate that steric and electrostatic effects primarily determine binding affinities.\u0000\u0000\u0000\u0000From the best model obtained from the QSAR analyses, some newer compounds of the same series were developed, having better activity than the\u0000earlier compounds that have been reported.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"129 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139006304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Computers play a vital role in people's lives because of their great precision, speed, and accuracy, as well as their ability to provide timely updates. A cascade of ocular and extraocular symptoms in computers or electronics leads to Computer Vision Syndrome. Ergonomics is the science of fitting job demands and workplace environments to the capabilities of the population. The use of a computer increases the risk of musculoskeletal issues, particularly in the upper extremities. The following research article elaborates on the surveys that were carried out in Maharishi Markandeshwar Deemed to be University Mullana, with 701 participants. Data were collected using the computer vision syndrome questionnaire and the ergonomics questionnaire for a duration of 6 months. The most prevalent symptom of CVS occasionally was found to be a headache (503 participants=71.7%), followed by eye heaviness and eye pain (483 participants=68.9%), burning sensation, itching and tearing (414 participants=59%), red eyes (361 participants=51.4%), foreign bodies (319 participants=45.5%), dryness (281 participants=40%), blurred and double vision (266 participants=37.9%), increased sensitivity to light and colored halos (249 participants=35.5%), and difficulty focusing (299 participants=42.6%). All symptoms of CVS suffered by the participants were on an occasional basis, constituting the majority and the most common CVS symptom as headache. In assessing the ergonomics, all participants experienced pain at least in one extremity and the majority of participants had their back bent while working with electronics.
计算机在人们的生活中发挥着至关重要的作用，因为它具有极高的精确度、速度和准确性，并能及时提供最新信息。计算机或电子产品引起的一系列眼部和眼外症状会导致计算机视觉综合症。人体工程学是一门使工作要求和工作环境与人们的能力相适应的科学。使用电脑会增加患肌肉骨骼问题的风险，尤其是上肢。以下研究文章阐述了在马哈希-马坎德斯瓦尔命名大学（Maharishi Markandeshwar Deemed to be University Mullana）进行的调查，共有 701 人参加。在为期 6 个月的调查中，使用电脑视觉综合症问卷和人体工程学问卷收集了数据。偶尔出现的电脑视觉综合症最普遍的症状是头痛（503 人=71.7%），其次是眼睛沉重和眼痛（483 人=68.9%）、灼热感、发痒和流泪（414 人=59%）、眼睛发红（361 人=51.4%）、异物感（31 人=51.4%）。参与者的所有 CVS 症状都是偶尔出现的，其中以头痛居多，也是最常见的 CVS 症状。在对人体工程学进行评估时，所有参与者至少有一侧肢体感到疼痛，大多数参与者在使用电子产品时背部弯曲。
{"title":"To Shed Light on the Association between Poor Ergophthalmologic Practices\u0000and Computer Vision Syndrome","authors":"Dakshita Hardatt, Gurvinder Singh, Navneet Kaur, akash j pethekar, Sumeet Gupta, Meenakshi Dhanawat","doi":"10.2174/012210299x247199231128100613","DOIUrl":"https://doi.org/10.2174/012210299x247199231128100613","url":null,"abstract":"\u0000\u0000Computers play a vital role in people's lives because of their great precision, speed, and accuracy, as well as their ability to provide timely updates.\u0000A cascade of ocular and extraocular symptoms in computers or electronics leads to Computer Vision Syndrome. Ergonomics is the science of\u0000fitting job demands and workplace environments to the capabilities of the population. The use of a computer increases the risk of musculoskeletal\u0000issues, particularly in the upper extremities.\u0000\u0000\u0000\u0000The following research article elaborates on the surveys that were carried out in Maharishi Markandeshwar Deemed to be University Mullana, with\u0000701 participants. Data were collected using the computer vision syndrome questionnaire and the ergonomics questionnaire for a duration of 6\u0000months.\u0000\u0000\u0000\u0000The most prevalent symptom of CVS occasionally was found to be a headache (503 participants=71.7%), followed by eye heaviness and eye pain\u0000(483 participants=68.9%), burning sensation, itching and tearing (414 participants=59%), red eyes (361 participants=51.4%), foreign bodies (319\u0000participants=45.5%), dryness (281 participants=40%), blurred and double vision (266 participants=37.9%), increased sensitivity to light and\u0000colored halos (249 participants=35.5%), and difficulty focusing (299 participants=42.6%).\u0000\u0000\u0000\u0000All symptoms of CVS suffered by the participants were on an occasional basis, constituting the majority and the most common CVS symptom as\u0000headache. In assessing the ergonomics, all participants experienced pain at least in one extremity and the majority of participants had their back\u0000bent while working with electronics.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139005637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
API analysis plays an important role in nourishing the quality, safety, efficacy, and potency of bulk drugs and pharmaceutical formulations. Increased drug products in the market lead to increased demand for new analytical techniques for Active Pharmaceutical Ingredient (API) analysis. During the past decades, method developments were necessitated for drug impurities, excipient profiling, and testing for biopharmaceuticals like dissolution and bioavailability. Moreover, advancements in the pharmaceutical industries necessitate upgrading newer technologies like analytical Quality by Design (QbD) and artificial intelligence. This review focused on analytical method development and its official guidelines provided by various regulatory bodies including ICH, US-FDA, AOAC, and USP. Moreover, this present art also states various validation and system parameters along with their applicability and recommended range. The critical appraisal of analytical technologies for performing various API analyses was also written in a scientific manner. Moreover, applications in recent trends in pharmaceutical industries as well as research were also documented. Hence, this review provides sufficient information for the readers for in-depth information starting from scratch to higher technologies for developing analytical methods and recent trends in the pharmaceutical industry.
{"title":"An Exhaustive Review on Recent Trends in Analytical Methods: Development\u0000Strategies and Recent Applications","authors":"Tanu Chaudhary, Akshay Kumar, N. Raj, GS Sarma, Shubham Dawange, Dilpreet Singh","doi":"10.2174/012210299x246468231115051717","DOIUrl":"https://doi.org/10.2174/012210299x246468231115051717","url":null,"abstract":"\u0000\u0000API analysis plays an important role in nourishing the quality, safety, efficacy, and potency of bulk drugs and pharmaceutical formulations.\u0000Increased drug products in the market lead to increased demand for new analytical techniques for Active Pharmaceutical Ingredient (API) analysis.\u0000During the past decades, method developments were necessitated for drug impurities, excipient profiling, and testing for biopharmaceuticals like\u0000dissolution and bioavailability. Moreover, advancements in the pharmaceutical industries necessitate upgrading newer technologies like analytical\u0000Quality by Design (QbD) and artificial intelligence. This review focused on analytical method development and its official guidelines provided by\u0000various regulatory bodies including ICH, US-FDA, AOAC, and USP. Moreover, this present art also states various validation and system\u0000parameters along with their applicability and recommended range. The critical appraisal of analytical technologies for performing various API\u0000analyses was also written in a scientific manner. Moreover, applications in recent trends in pharmaceutical industries as well as research were also\u0000documented. Hence, this review provides sufficient information for the readers for in-depth information starting from scratch to higher\u0000technologies for developing analytical methods and recent trends in the pharmaceutical industry.\u0000","PeriodicalId":479738,"journal":{"name":"Current Indian Science","volume":"103 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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