Pub Date : 2022-03-24DOI: 10.1007/s11251-022-09581-w
Chao-Jung Wu, Chia-Yu Liu
{"title":"Refined use of the eye-mind hypothesis for scientific argumentation using multiple representations","authors":"Chao-Jung Wu, Chia-Yu Liu","doi":"10.1007/s11251-022-09581-w","DOIUrl":"https://doi.org/10.1007/s11251-022-09581-w","url":null,"abstract":"","PeriodicalId":47990,"journal":{"name":"Instructional Science","volume":"50 1","pages":"551 - 569"},"PeriodicalIF":2.5,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48153773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-23DOI: 10.1007/s11251-022-09582-9
L. Minshew, Janice L. Anderson, Kerry A. Bartlett
{"title":"Outside the standard test: The development of a model-based assessment and corresponding rubric","authors":"L. Minshew, Janice L. Anderson, Kerry A. Bartlett","doi":"10.1007/s11251-022-09582-9","DOIUrl":"https://doi.org/10.1007/s11251-022-09582-9","url":null,"abstract":"","PeriodicalId":47990,"journal":{"name":"Instructional Science","volume":"50 1","pages":"599 - 624"},"PeriodicalIF":2.5,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44916991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-22DOI: 10.1007/s11251-022-09588-3
Tapio Rasa, E. Palmgren, Antti Laherto
{"title":"Correction to: Futurising science education: students’ experiences from a course on futures thinking and quantum computing","authors":"Tapio Rasa, E. Palmgren, Antti Laherto","doi":"10.1007/s11251-022-09588-3","DOIUrl":"https://doi.org/10.1007/s11251-022-09588-3","url":null,"abstract":"","PeriodicalId":47990,"journal":{"name":"Instructional Science","volume":"50 1","pages":"449 - 449"},"PeriodicalIF":2.5,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45431992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.1007/s11251-022-09580-x
Tasos Hovardas, Z. Zacharia, N. Xenofontos, Ton de Jong
{"title":"How many words are enough? Investigating the effect of different configurations of a software scaffold for formulating scientific hypotheses in inquiry-oriented contexts","authors":"Tasos Hovardas, Z. Zacharia, N. Xenofontos, Ton de Jong","doi":"10.1007/s11251-022-09580-x","DOIUrl":"https://doi.org/10.1007/s11251-022-09580-x","url":null,"abstract":"","PeriodicalId":47990,"journal":{"name":"Instructional Science","volume":"50 1","pages":"361 - 390"},"PeriodicalIF":2.5,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47910298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microglial cells are well-known phagocytic cells that are resistant to the central nervous system (CNS) and play an important role in the maintenance of CNS homeostasis. Activated microglial cells induce neuroinflammation under hypoxia and typically cause neuronal damage in CNS diseases. In this study, we propose that wild bitter melon extract (WBM) has a protective effect on hypoxia-induced cell death via regulation of ferroptosis, ER stress, and apoptosis. The results demonstrated that hypoxia caused microglial BV-2 the accumulation of lipid ROS, ferroptosis, ER stress, and apoptosis. In this study, we investigated the pharmacological effects of WBM on BV-2 cells following hypoxia-induced cell death. The results indicated that WBM reversed hypoxia-downregulated antiferroptotic molecules Gpx4 and SLC7A11, as well as upregulated the ER stress markers CHOP and Bip. Moreover, WBM alleviated hypoxia-induced apoptosis via the regulation of cleaved-caspase 3, Bax, and Bcl-2. Our results suggest that WBM may be a good candidate for preventing CNS disorders in the future.
小胶质细胞是众所周知的吞噬细胞，对中枢神经系统（CNS）具有抵抗力，在维持中枢神经系统稳态方面发挥着重要作用。在缺氧条件下，活化的小胶质细胞会诱发神经炎症，通常会在中枢神经系统疾病中造成神经元损伤。在这项研究中，我们提出野苦瓜提取物（WBM）通过调节铁变态反应、ER应激和细胞凋亡对缺氧诱导的细胞死亡具有保护作用。结果表明，缺氧导致小胶质细胞BV-2脂质ROS积累、铁变态反应、ER应激和细胞凋亡。在本研究中，我们研究了 WBM 在缺氧诱导细胞死亡后对 BV-2 细胞的药理作用。结果表明，WBM 逆转了缺氧下调的抗铁细胞凋亡分子 Gpx4 和 SLC7A11，并上调了 ER 应激标志物 CHOP 和 Bip。此外，WBM 还能通过调节裂解的天冬酶 3、Bax 和 Bcl-2 缓解缺氧诱导的细胞凋亡。我们的研究结果表明，WBM 可能是未来预防中枢神经系统疾病的良好候选药物。
{"title":"Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells.","authors":"Chih-Hung Lin, Jiunn-Sheng Wu, Po-Chun Hsieh, Valeria Chiu, Chou-Chin Lan, Chan-Yen Kuo","doi":"10.1155/2022/1072600","DOIUrl":"10.1155/2022/1072600","url":null,"abstract":"<p><p>Microglial cells are well-known phagocytic cells that are resistant to the central nervous system (CNS) and play an important role in the maintenance of CNS homeostasis. Activated microglial cells induce neuroinflammation under hypoxia and typically cause neuronal damage in CNS diseases. In this study, we propose that wild bitter melon extract (WBM) has a protective effect on hypoxia-induced cell death via regulation of ferroptosis, ER stress, and apoptosis. The results demonstrated that hypoxia caused microglial BV-2 the accumulation of lipid ROS, ferroptosis, ER stress, and apoptosis. In this study, we investigated the pharmacological effects of WBM on BV-2 cells following hypoxia-induced cell death. The results indicated that WBM reversed hypoxia-downregulated antiferroptotic molecules Gpx4 and SLC7A11, as well as upregulated the ER stress markers CHOP and Bip. Moreover, WBM alleviated hypoxia-induced apoptosis via the regulation of cleaved-caspase 3, Bax, and Bcl-2. Our results suggest that WBM may be a good candidate for preventing CNS disorders in the future.</p>","PeriodicalId":47990,"journal":{"name":"Instructional Science","volume":"34 1","pages":"1072600"},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74268359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.1007/s11251-022-09579-4
S. Bichler, Matthias Stadler, M. Bühner, Samuel Greiff, F. Fischer
{"title":"Learning to solve ill-defined statistics problems: does self-explanation quality mediate the worked example effect?","authors":"S. Bichler, Matthias Stadler, M. Bühner, Samuel Greiff, F. Fischer","doi":"10.1007/s11251-022-09579-4","DOIUrl":"https://doi.org/10.1007/s11251-022-09579-4","url":null,"abstract":"","PeriodicalId":47990,"journal":{"name":"Instructional Science","volume":"50 1","pages":"335 - 359"},"PeriodicalIF":2.5,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48578693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-02DOI: 10.1007/s11251-021-09572-3
Tapio Rasa, E. Palmgren, Antti Laherto
{"title":"Futurising science education: students’ experiences from a course on futures thinking and quantum computing","authors":"Tapio Rasa, E. Palmgren, Antti Laherto","doi":"10.1007/s11251-021-09572-3","DOIUrl":"https://doi.org/10.1007/s11251-021-09572-3","url":null,"abstract":"","PeriodicalId":47990,"journal":{"name":"Instructional Science","volume":"50 1","pages":"425 - 447"},"PeriodicalIF":2.5,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47158370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-18DOI: 10.1007/s11251-021-09576-z
Dina Nesimyan – Agadi, Orit Ben Zvi Assaraf
{"title":"Figuring out what works: learning and engaging with ideas about evolution within integrated informal learning environments","authors":"Dina Nesimyan – Agadi, Orit Ben Zvi Assaraf","doi":"10.1007/s11251-021-09576-z","DOIUrl":"https://doi.org/10.1007/s11251-021-09576-z","url":null,"abstract":"","PeriodicalId":47990,"journal":{"name":"Instructional Science","volume":"50 1","pages":"391 - 424"},"PeriodicalIF":2.5,"publicationDate":"2022-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42063195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-11DOI: 10.1007/s11251-021-09575-0
C. Haelermans
{"title":"The Effects of Group differentiation by students’ learning strategies","authors":"C. Haelermans","doi":"10.1007/s11251-021-09575-0","DOIUrl":"https://doi.org/10.1007/s11251-021-09575-0","url":null,"abstract":"","PeriodicalId":47990,"journal":{"name":"Instructional Science","volume":"50 1","pages":"223 - 250"},"PeriodicalIF":2.5,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49120083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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