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Māori experiences and perspectives of hospital treatment in the context of acute care. 毛利人在急诊治疗中对医院治疗的体验和看法。
IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-23 DOI: 10.26635/6965.6397
Misty Edmonds, Stephanie Shankar, Te Inuwai Elia, Carlos Fc Campos, Mataroria Lyndon, Jennifer M Weller

Aim: Through exploring Māori experiences when presenting acutely to hospital, we aimed to identify specific aspects of culturally safe care that we could incorporate into healthcare professionals' training and hospital processes.

Methods: Using Kaupapa Māori approaches, we undertook semi-structured interviews and thematic analysis to collect and analyse data from diverse groups of Māori participants.

Results: We interviewed 17 participants, with 16 follow-up interviews. We found a lack of trust, and perceptions of unequal treatment for Māori. Our participants highlighted the following key needs: the importance of whanaungatanga in building trusting relationships with patients and whānau; creating safe spaces for patients and whānau; improved staff cultural safety; exploring individual patient and whānau needs, avoiding assumptions about cultural requirements or stereotypical characteristics; upholding the mana of all patients with respectful interactions; and empowering Māori as partners in their care.

Conclusion: By sharing their personal experiences, participants have highlighted specific aspects of their interactions with hospital staff and the healthcare system that could and should be improved. These insights can guide our efforts to enhance cultural safety for Māori patients and whānau through targeted staff training and structural changes.

目的:通过探究毛利人在急诊入院时的经历,我们旨在确定文化安全护理的具体方面,并将其纳入医护人员的培训和医院流程中:方法:我们采用Kaupapa毛利方法,进行了半结构式访谈和主题分析,以收集和分析来自不同毛利参与者群体的数据:我们采访了 17 位参与者,并进行了 16 次后续采访。我们发现毛利人缺乏信任,并认为他们受到了不平等的待遇。我们的参与者强调了以下关键需求:whanaungatanga在与患者和毛利人建立信任关系方面的重要性;为患者和毛利人创造安全的空间;提高员工的文化安全;探索患者和毛利人的个人需求,避免对文化要求或陈规定型特征的假设;以尊重的互动方式维护所有患者的mana;将毛利人作为其护理工作的合作伙伴,赋予他们权力:通过分享他们的亲身经历,参与者们强调了他们与医院员工和医疗保健系统互动过程中可以而且应该改进的具体方面。这些见解可以指导我们通过有针对性的员工培训和结构改革,努力提高毛利病人和毛利家族的文化安全。
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引用次数: 0
Acute and persistent post-operative pain following mastectomy: a descriptive study in a tertiary hospital cohort. 乳房切除术后的急性和持续性术后疼痛:一项在三级医院队列中进行的描述性研究。
IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-23 DOI: 10.26635/6965.6524
Jenna Donaldson, Sami Swadi, Chris Frampton, Christian Brett

Aims: Post mastectomy pain syndrome (PMPS) can have significant negative effects on patients' quality of life after mastectomy. The estimated prevalence of PMPS varies widely and there is little data from a New Zealand population. This limits clinicians' ability to meaningfully describe and discuss pain-related complications of mastectomy peri-operatively.

Method: We designed a single-centre, retrospective study to describe acute post-operative analgesic requirements after mastectomy, to describe the prevalence of PMPS at least 1 year after surgery, and to identify associated risk factors for this complication.

Results: One hundred and thirty mastectomy patients met inclusion criteria and 59 were willing and able to participate in 12-month follow-up. Acute post-operative pain was generally well managed with modest doses of oral analgesics. Sixty-six percent (n=39) of women reported some form of persistent pain symptoms post-mastectomy; this was associated with younger age, axillary surgery and chemotherapy. Only 5% of patients (n=3) met consensus criteria for PMPS, which limited identification of risk factors for this more severe complication.

Conclusion: Despite PMPS occurring infrequently, post-operative pain of a less severe nature after mastectomy occurs commonly. Clinicians should remain vigilant to possible risk factors for this post-operative complication and counsel patients appropriately.

目的:乳房切除术后疼痛综合征(PMPS)会对乳房切除术后患者的生活质量产生严重的负面影响。PMPS 的估计患病率差异很大,而且新西兰人口的数据很少。这限制了临床医生有意义地描述和讨论乳房切除术围手术期疼痛相关并发症的能力:我们设计了一项单中心、回顾性研究,以描述乳房切除术后的急性术后镇痛需求,描述术后至少 1 年 PMPS 的患病率,并确定该并发症的相关风险因素:130名乳房切除术患者符合纳入标准,其中59人愿意并能够参加12个月的随访。术后急性疼痛一般通过适量的口服镇痛药得到了很好的控制。66%的妇女(39 人)报告在乳房切除术后出现某种形式的持续疼痛症状;这与年龄较小、腋窝手术和化疗有关。只有5%的患者(3人)符合PMPS的共识标准,这限制了对这种更严重并发症风险因素的识别:结论:尽管PMPS不常发生,但乳房切除术后较轻微的术后疼痛却很常见。临床医生应该对这种术后并发症的可能风险因素保持警惕,并为患者提供适当的建议。
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引用次数: 0
Ad hominem; Author information or conflict of interest. 谩骂;作者信息或利益冲突。
IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-23 DOI: 10.26635/6965.l1601
Ben Lawrence, Simon Gordon, Elizaveta Rakhmanova, William Park, Johnathan Reynecke, Frank Frizelle
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引用次数: 0
Do parents of children with cancer use religious coping in New Zealand? 在新西兰,患癌儿童的父母是否使用宗教应对方法?
IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-23 DOI: 10.26635/6965.6466
Hüseyin Çaksen
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引用次数: 0
Safety and feasibility of same-day discharge for per-oral endoscopic myotomy. 经口内窥镜肌切开术当天出院的安全性和可行性。
IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-23 DOI: 10.26635/6965.6583
Jun Young Kim, Michael Chieng, Rees Cameron, Frank Weilert

Aims: Per-oral endoscopic myotomy (POEM) is a recognised treatment for achalasia, with the accepted approach involving admission for imaging and dietary progression. However, recent publications suggest same-day discharge (SDD) may be possible, which could be time and cost-saving. We sought to investigate the safety of SDD following POEM.

Methods: Fifty consecutive POEMs at two referral centres in New Zealand were performed between 2020-2023. All patients were planned for early dietary introduction and were eligible for SDD if symptoms were managed. Analgesia was available in recovery and supplied at discharge. Imaging and endoscopy were performed only if there were clinical concerns. Rates of discharge clearance, discharge, complications and re-admission were analysed.

Results: All 50 POEMs were technically successful. A total of 41/50 (82%) received clearance for SDD. Additionally, 35/50 (70%) achieved discharge and 6/50 (12%) were observed overnight for social reasons, including lack of transport to the referring domicile. Of the patients not cleared for SDD, 7/9 (78%) were discharged within 24 hours, and the others after 48 and 72 hours. Procedural complications were recorded in three patients (6%), with one requiring endoscopic assessment and clipping. There were two re-admissions (4%), both lt;24-hour hospital stays, and managed medically.

Conclusions: The majority of patients achieved same-day discharge clearance (82%) and 96% required less than 24 hours hospital stay. Complication and re-admission rates were low overall. We have demonstrated that POEM can be an SDD procedure facilitated by early dietary introduction and liberal analgesia, without the need for routine imaging or endoscopy.

目的:经口内窥镜肌切开术(POEM)是公认的治疗贲门失弛缓症的方法,公认的方法包括入院进行影像学检查和饮食治疗。然而,最近的出版物表明,当天出院(SDD)是可能的,这可以节省时间和费用。我们试图研究 POEM 后 SDD 的安全性:2020-2023 年间,新西兰两家转诊中心连续进行了 50 例 POEM。所有患者均计划进行早期饮食导入,如果症状得到控制,则有资格进行 SDD。恢复期可使用镇痛剂,出院时也可使用。只有在有临床问题时才进行成像和内窥镜检查。对出院清除率、出院率、并发症和再次入院率进行了分析:所有 50 例 POEM 在技术上都很成功。共有 41/50 例(82%)获得了 SDD 许可。此外,35/50(70%)的患者获得出院,6/50(12%)的患者因社会原因(包括缺乏前往转诊地的交通工具)而需要留院观察一晚。在未获准进行 SDD 的患者中,7/9(78%)在 24 小时内出院,其他患者分别在 48 小时和 72 小时后出院。三名患者(6%)出现了手术并发症,其中一名患者需要进行内窥镜评估和剪切。有两名患者(4%)再次入院,均住院24小时,并接受了药物治疗:大多数患者都能在当天出院(82%),96%的患者住院时间少于24小时。并发症和再次入院率总体较低。我们已经证明,POEM 可以是一种 SDD 手术,通过早期饮食导入和宽松的镇痛,无需进行常规成像或内窥镜检查。
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引用次数: 0
Promoting digital inclusion for enhanced resident wellbeing: an examination of aged residential care facility websites. 促进数字共融,提升居民福祉:对养老机构网站的研究。
IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-23 DOI: 10.26635/6965.6511
Wendy Wrapson, Chiara Gasteiger

Aim: Digital inclusion has a positive impact on health and wellbeing through fostering connectivity and access to information. In Aotearoa New Zealand, 4% of older adults live in aged residential care (ARC) facilities and are vulnerable to social isolation. This study explored whether ARC facilities provide opportunities to socially connect online and whether the COVID-19 pandemic affected the provision of these opportunities.

Method: Information on technology and internet provision from 558 ARC facilities was extracted from facilities' own or related websites in 2019 and 2021. ARC facilities were categorised according to whether they provided digital devices, internet access and internet-based leisure activities, or made no reference to technology.

Results: In 2019, 392 (70%) of 558 ARC facilities publicised availability of internet-based technologies for residents; however, only 46 (8%) mentioned providing access to computer devices. In 2021 (during the pandemic), there was a small increase to 421 (76%) and 54 (10%) of facilities respectively. Facilities mentioning internet-based leisure activities were 63 (11%) in 2019 and 55 (10%) in 2021. Those not referring to technology had reduced from 166 (30%) in 2019 to 137 (24%) in 2021.

Conclusion: Few ARC facilities enabled residents to fully access the digital world, even after periods of isolation due to COVID-19. Aged care providers could be more proactive by providing internet access and digital learning opportunities.

目的:数字包容性通过促进连接和信息获取,对健康和福祉产生积极影响。在新西兰奥特亚罗瓦,4% 的老年人生活在老年寄宿护理机构(ARC)中,容易受到社会孤立。本研究探讨了老年寄宿护理机构是否提供了在线社交联系的机会,以及 COVID-19 大流行是否影响了这些机会的提供:方法:研究人员从 558 家 ARC 机构的自有网站或相关网站上提取了 2019 年和 2021 年的技术和网络提供信息。ARC 设施根据是否提供数字设备、互联网接入和基于互联网的休闲活动,或未提及技术进行分类:2019年,558家ARC设施中有392家(70%)宣传可为居民提供基于互联网的技术;但只有46家(8%)提到可提供电脑设备。到了 2021 年(大流行期间),提及为居民提供互联网技术的设施分别小幅增加到 421 家(76%)和 54 家(10%)。提及互联网休闲活动的设施在 2019 年为 63 个(11%),2021 年为 55 个(10%)。未提及科技的设施从 2019 年的 166 个(30%)减少到 2021 年的 137 个(24%):结论:即使在因 COVID-19 而被隔离一段时间后,也很少有 ARC 设施能让居民充分访问数字世界。老年护理机构可以通过提供互联网接入和数字化学习机会来更加积极主动地开展工作。
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引用次数: 0
Twenty-year review of the bariatric programme at Te Whatu Ora Waitematā. Te Whatu Ora Waitematā减肥计划二十年回顾。
IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-23 DOI: 10.26635/6965.6472
Megan Grinlinton, Mavis Orizu, Michael Booth

Aims: Obesity is a significant health issue. Te Whatu Ora Waitematā serves a population of 650,000 patients across the North Shore, Waitākere and Rodney areas. The Waitematā bariatric service at North Shore Hospital was introduced in October 2001. The aim of this study was to review the development and impact of the service over the last 20 years, and identify whether equivalent bariatric services could viably be introduced into other hospitals in Aotearoa New Zealand.

Methods: A retrospective audit was conducted of the 20-year results of the Waitematā bariatric surgical service to identify the impact of technology, teaching and research on service provision.

Results: Since its inception, the Waitematā bariatric service has launched minimally invasive surgery, multiple operative options and an enhanced recovery after surgery (ERAS) protocol. Approximately 100 cases are performed per year. Of these, 3.4% of patients require admission to the intensive care unit/high dependency unit (ICU/HDU), with an average length of stay (LOS) of 0.66 days. The 1-year mortality rate is 0.39%. Eleven surgical fellows have undergone post-fellowship training with the service, which is a recognised training unit for the post-fellowship AANZGOSA/ANZMOSS programme.

Conclusions: Bariatric surgery can be performed safely and has good long-term outcomes. The Waitematā bariatric service is dedicated to providing excellent care within the resource constraints of a public healthcare system. The high number of procedures, low requirement for ICU/HDU and low mortality rate suggest that bariatric surgery could be safely performed within a public setting in secondary and regional hospitals across the country.

目的:肥胖症是一个严重的健康问题。Te Whatu Ora Waitematā 为北岸、怀塔凯尔和罗德尼地区的 65 万病人提供服务。北岸医院于 2001 年 10 月推出了 Waitematā 减肥服务。这项研究的目的是回顾过去20年中这项服务的发展和影响,并确定是否可以在新西兰奥特亚罗瓦的其他医院中引入类似的减肥服务:方法:对Waitematā减肥手术服务20年来的成果进行回顾性审核,以确定技术、教学和研究对服务提供的影响:自成立以来,Waitematā 减肥服务推出了微创手术、多种手术方案和增强型术后恢复(ERAS)方案。每年大约进行 100 例手术。其中,3.4% 的患者需要入住重症监护室/高依赖性病房(ICU/HDU),平均住院时间(LOS)为 0.66 天。1 年死亡率为 0.39%。11名外科研究员在该服务机构接受了研究员后培训,该服务机构是AANZGOSA/ANZMOSS研究员后计划的认可培训单位:结论:减肥手术可以安全地进行,并且具有良好的长期疗效。怀特马减肥服务致力于在公共医疗系统资源有限的情况下提供优质护理。手术数量多、对重症监护室/重症加护病房的需求低、死亡率低,这表明减肥手术可以在全国各地的二级医院和地区医院的公共环境中安全进行。
{"title":"Twenty-year review of the bariatric programme at Te Whatu Ora Waitematā.","authors":"Megan Grinlinton, Mavis Orizu, Michael Booth","doi":"10.26635/6965.6472","DOIUrl":"https://doi.org/10.26635/6965.6472","url":null,"abstract":"<p><strong>Aims: </strong>Obesity is a significant health issue. Te Whatu Ora Waitematā serves a population of 650,000 patients across the North Shore, Waitākere and Rodney areas. The Waitematā bariatric service at North Shore Hospital was introduced in October 2001. The aim of this study was to review the development and impact of the service over the last 20 years, and identify whether equivalent bariatric services could viably be introduced into other hospitals in Aotearoa New Zealand.</p><p><strong>Methods: </strong>A retrospective audit was conducted of the 20-year results of the Waitematā bariatric surgical service to identify the impact of technology, teaching and research on service provision.</p><p><strong>Results: </strong>Since its inception, the Waitematā bariatric service has launched minimally invasive surgery, multiple operative options and an enhanced recovery after surgery (ERAS) protocol. Approximately 100 cases are performed per year. Of these, 3.4% of patients require admission to the intensive care unit/high dependency unit (ICU/HDU), with an average length of stay (LOS) of 0.66 days. The 1-year mortality rate is 0.39%. Eleven surgical fellows have undergone post-fellowship training with the service, which is a recognised training unit for the post-fellowship AANZGOSA/ANZMOSS programme.</p><p><strong>Conclusions: </strong>Bariatric surgery can be performed safely and has good long-term outcomes. The Waitematā bariatric service is dedicated to providing excellent care within the resource constraints of a public healthcare system. The high number of procedures, low requirement for ICU/HDU and low mortality rate suggest that bariatric surgery could be safely performed within a public setting in secondary and regional hospitals across the country.</p>","PeriodicalId":48086,"journal":{"name":"NEW ZEALAND MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asian health in Aotearoa New Zealand: highlights and actionable insights. 新西兰奥特亚罗亚的亚裔健康:亮点和可行见解。
IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-23 DOI: 10.26635/6965.6705
Sherly Parackal, Eleanor Holroyd
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引用次数: 0
Diabetes treatment satisfaction among a multi-ethnic Aotearoa New Zealand population with uncontrolled type 2 diabetes mellitus. 新西兰奥特亚罗瓦多民族未受控制的 2 型糖尿病患者对糖尿病治疗的满意度。
IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-02 DOI: 10.26635/6965.6341
Ry Yves Tweedie-Cullen, Yannan Jiang, Rebecca Brandon, Audrey Tay, Ryan Yeu, Kate Smallman, Glenn Doherty, Ofa Dewes, Rebekah Doran, Penny Clark, Norma Nehren, Jennie Harré Hindmarsh, Frances King, Tony R Merriman, Brandon Orr-Walker, Ryan Paul, Rinki Murphy, Allan Moffitt

Aims: To assess whether diabetes treatment satisfaction differs by ethnicity among participants with insufficient glycaemic control of type 2 diabetes mellitus in a clinical trial involving additional oral diabetes medications. Patient satisfaction is used as an indicator of healthcare quality. However, data on patients' diabetes treatment satisfaction in the context of insufficient glycaemic control is limited.

Methods: Individuals with type 2 diabetes and an HbA1c of 58-110mmol/mol (7.5-12.5%) were recruited across Aotearoa New Zealand to participate in an 8-month randomised crossover study of vildagliptin and pioglitazone as add-on therapy to metformin and/or sulfonylurea. Participants completed the Diabetes Treatment Satisfaction Questionnaire (DTSQ) at baseline pre-randomisation. Treatment satisfaction scores were compared between ethnic groups and other characteristics using the analysis of variance and linear regression. Perceived hyper- and hypoglycaemia were summarised separately.

Results: Between February 2019 and March 2020, 346 participants (41% women, 32% Pacific peoples, 23% Māori, 26% European) completed the DTSQ. Mean (SD) age was 57.5 (10.9) years, diabetes duration was 9 (6.3) years and HbA1c was 75 (12)mmol/mol (9.0[3.2]%). At study entry, 40% were receiving monotherapy for diabetes. Treatment satisfaction was rated highly, with a score of 29(6) (interquartile range 25-33). Pacific peoples and older people reported greater treatment satisfaction than other groups (p<0.001).

Conclusions: Diabetes treatment satisfaction was high, particularly among Pacific peoples, despite suboptimal glycaemic control and insufficient glucose-lowering therapy.

目的:在一项涉及额外口服糖尿病药物的临床试验中,评估血糖控制不佳的 2 型糖尿病参与者的糖尿病治疗满意度是否因种族而异。患者满意度被用作衡量医疗质量的指标。然而,有关患者在血糖控制不足的情况下对糖尿病治疗满意度的数据却很有限:方法:在新西兰奥特亚罗亚地区招募 HbA1c 为 58-110mmol/mol (7.5-12.5%) 的 2 型糖尿病患者,参加为期 8 个月的随机交叉研究,将维达列汀和吡格列酮作为二甲双胍和/或磺脲类药物的附加疗法。参与者在随机前的基线填写了糖尿病治疗满意度问卷(DTSQ)。采用方差分析和线性回归法比较了不同种族群体和其他特征之间的治疗满意度得分。分别总结了感知到的高血糖和低血糖情况:2019年2月至2020年3月期间,346名参与者(41%为女性,32%为太平洋岛屿族裔,23%为毛利人,26%为欧洲人)完成了DTSQ。平均(标清)年龄为 57.5 (10.9) 岁,糖尿病病程为 9 (6.3) 年,HbA1c 为 75 (12)mmol/mol (9.0[3.2]%)。研究开始时,40%的糖尿病患者正在接受单一疗法。患者对治疗的满意度很高,得分为 29(6)(四分位数间距为 25-33)。太平洋岛民和老年人的治疗满意度高于其他群体(P结论:尽管血糖控制不理想且降糖治疗不足,但糖尿病治疗满意度很高,尤其是太平洋岛屿族裔。
{"title":"Diabetes treatment satisfaction among a multi-ethnic Aotearoa New Zealand population with uncontrolled type 2 diabetes mellitus.","authors":"Ry Yves Tweedie-Cullen, Yannan Jiang, Rebecca Brandon, Audrey Tay, Ryan Yeu, Kate Smallman, Glenn Doherty, Ofa Dewes, Rebekah Doran, Penny Clark, Norma Nehren, Jennie Harré Hindmarsh, Frances King, Tony R Merriman, Brandon Orr-Walker, Ryan Paul, Rinki Murphy, Allan Moffitt","doi":"10.26635/6965.6341","DOIUrl":"https://doi.org/10.26635/6965.6341","url":null,"abstract":"<p><strong>Aims: </strong>To assess whether diabetes treatment satisfaction differs by ethnicity among participants with insufficient glycaemic control of type 2 diabetes mellitus in a clinical trial involving additional oral diabetes medications. Patient satisfaction is used as an indicator of healthcare quality. However, data on patients' diabetes treatment satisfaction in the context of insufficient glycaemic control is limited.</p><p><strong>Methods: </strong>Individuals with type 2 diabetes and an HbA1c of 58-110mmol/mol (7.5-12.5%) were recruited across Aotearoa New Zealand to participate in an 8-month randomised crossover study of vildagliptin and pioglitazone as add-on therapy to metformin and/or sulfonylurea. Participants completed the Diabetes Treatment Satisfaction Questionnaire (DTSQ) at baseline pre-randomisation. Treatment satisfaction scores were compared between ethnic groups and other characteristics using the analysis of variance and linear regression. Perceived hyper- and hypoglycaemia were summarised separately.</p><p><strong>Results: </strong>Between February 2019 and March 2020, 346 participants (41% women, 32% Pacific peoples, 23% Māori, 26% European) completed the DTSQ. Mean (SD) age was 57.5 (10.9) years, diabetes duration was 9 (6.3) years and HbA1c was 75 (12)mmol/mol (9.0[3.2]%). At study entry, 40% were receiving monotherapy for diabetes. Treatment satisfaction was rated highly, with a score of 29(6) (interquartile range 25-33). Pacific peoples and older people reported greater treatment satisfaction than other groups (p<0.001).</p><p><strong>Conclusions: </strong>Diabetes treatment satisfaction was high, particularly among Pacific peoples, despite suboptimal glycaemic control and insufficient glucose-lowering therapy.</p>","PeriodicalId":48086,"journal":{"name":"NEW ZEALAND MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adherence to national Lynch syndrome testing guidelines for colorectal cancer in an Aotearoa New Zealand hospital-based population. 新西兰奥特亚罗瓦医院人群中遵守国家林奇综合征结直肠癌检测指南的情况。
IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-02 DOI: 10.26635/6965.6551
Nejo Joseph, Matthew McGuinness, Cavaghn H Prosser, Georgina Trifinovich, William Xu, Christopher Harmston

Aim: Lynch syndrome (LS) is estimated to affect 1-3.9% of patients with colorectal cancer (CRC). Testing for LS is important in determining management and establishing surveillance for "Lynch families". Previous studies have identified poor rates of testing for LS in CRC patients. This study aimed to describe adherence to guidelines for testing of newly diagnosed CRC for LS.

Methods: A single institution cohort study of patients over 18 years with colorectal adenocarcinoma from 2018-2022 in Te Tai Tokerau, Aotearoa New Zealand was conducted. Rates of baseline immunohistochemistry (IHC) testing for mismatch repair (MMR) deficiency, further testing for MLH1-deficient cases and rates of germline mutational analysis were audited to determine adherence to national guidelines. The rate of LS in newly diagnosed CRC was estimated.

Results: Six hundred and sixty patients were eligible for universal testing for LS, of which 84% (n=553) completed initial IHC testing. MMR deficiency was reported in 20% (n=114) cases. Eighty-nine percent (n=101) was attributable to MLH1 deficiency, of which 99% (n=100) were appropriately tested for BRAF-V600E mutation. Sixty-four percent (4/11) patients indicated for hypermethylation testing were appropriately tested. Seventeen patients had an indication for germline mutational analysis, of which only 29% (n=5) were tested. The estimated incidence of LS in newly diagnosed CRC was 0.7-3.8%.

Conclusion: Compliance with initial IHC testing was good. However, there is a need to improve rates of confirmation genetic testing. The incidence of confirmed LS in this study is 0.7%, however this may be as high as 3.9%.

目的:据估计,1-3.9% 的结直肠癌 (CRC) 患者患有林奇综合征 (LS)。林奇综合征检测对于确定治疗方案和建立 "林奇家族 "监测非常重要。以往的研究发现,CRC 患者的 LS 检测率很低。本研究旨在描述新诊断 CRC LS 检测指南的遵守情况:该研究对新西兰奥特亚罗瓦 Te Tai Tokerau 地区 2018-2022 年间 18 岁以上结直肠腺癌患者进行了单机构队列研究。对错配修复(MMR)缺陷的基线免疫组化(IHC)检测率、MLH1缺陷病例的进一步检测率和种系突变分析率进行了审核,以确定是否符合国家指南。对新诊断出的 CRC 的 LS 率进行了估算:有660名患者符合LS普遍检测的条件,其中84%(n=553)的患者完成了初步IHC检测。20%的病例(n=114)报告缺乏 MMR。89%的病例(n=101)可归因于MLH1缺乏,其中99%的病例(n=100)进行了适当的BRAF-V600E突变检测。64%(4/11)的患者有进行高甲基化检测的指征,并进行了适当的检测。17名患者有进行种系突变分析的指征,其中只有29%(n=5)的患者接受了检测。在新诊断的 CRC 中,LS 的估计发生率为 0.7%-3.8%:结论:初次 IHC 检测的依从性良好。然而,需要提高基因检测的确认率。本研究中确诊 LS 的发生率为 0.7%,但可能高达 3.9%。
{"title":"Adherence to national Lynch syndrome testing guidelines for colorectal cancer in an Aotearoa New Zealand hospital-based population.","authors":"Nejo Joseph, Matthew McGuinness, Cavaghn H Prosser, Georgina Trifinovich, William Xu, Christopher Harmston","doi":"10.26635/6965.6551","DOIUrl":"10.26635/6965.6551","url":null,"abstract":"<p><strong>Aim: </strong>Lynch syndrome (LS) is estimated to affect 1-3.9% of patients with colorectal cancer (CRC). Testing for LS is important in determining management and establishing surveillance for \"Lynch families\". Previous studies have identified poor rates of testing for LS in CRC patients. This study aimed to describe adherence to guidelines for testing of newly diagnosed CRC for LS.</p><p><strong>Methods: </strong>A single institution cohort study of patients over 18 years with colorectal adenocarcinoma from 2018-2022 in Te Tai Tokerau, Aotearoa New Zealand was conducted. Rates of baseline immunohistochemistry (IHC) testing for mismatch repair (MMR) deficiency, further testing for MLH1-deficient cases and rates of germline mutational analysis were audited to determine adherence to national guidelines. The rate of LS in newly diagnosed CRC was estimated.</p><p><strong>Results: </strong>Six hundred and sixty patients were eligible for universal testing for LS, of which 84% (n=553) completed initial IHC testing. MMR deficiency was reported in 20% (n=114) cases. Eighty-nine percent (n=101) was attributable to MLH1 deficiency, of which 99% (n=100) were appropriately tested for BRAF-V600E mutation. Sixty-four percent (4/11) patients indicated for hypermethylation testing were appropriately tested. Seventeen patients had an indication for germline mutational analysis, of which only 29% (n=5) were tested. The estimated incidence of LS in newly diagnosed CRC was 0.7-3.8%.</p><p><strong>Conclusion: </strong>Compliance with initial IHC testing was good. However, there is a need to improve rates of confirmation genetic testing. The incidence of confirmed LS in this study is 0.7%, however this may be as high as 3.9%.</p>","PeriodicalId":48086,"journal":{"name":"NEW ZEALAND MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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