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Implementing a behavioral physical activity program in children and adolescent survivors of childhood cancer: a pilot randomized controlled trial. 在儿童癌症幸存者和青少年中实施行为体育活动计划:随机对照试验。
IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2024-10-01 Epub Date: 2024-05-12 DOI: 10.1007/s10865-024-00497-z
Maxime Caru, Smita Dandekar, Brett Gordon, David E Conroy, Emily D Barb, Shawna E Doerksen, Gayle M Smink, Daniel J McKeone, Nidhi B Shah, Robert J Greiner, Joseph W Schramm, Pooja Rao, Lisa McGregor, Kathryn H Schmitz

Purpose We aimed to document the acceptability (enrollment rate) and feasibility (phone call delivery rate) of implementing a behavioral PA intervention over 12 weeks, in addition to documenting its effects on patient-reported outcomes and physical functioning. This study also describes the costs of carrying out a behavioral PA intervention. A total of 40 participants were randomized in a 1:1 ratio. The tailored behavioral PA intervention was developed based on the most recent PA guidelines in pediatric oncology and on the COM-B framework to enact PA behavior changes. The prescription (frequency, intensity, time and type (FITT)) was adjusted each week during the weekly support calls. The control group did not receive the intervention. 26 males and 14 females (13.6 years old on average and 2.9 years post-cancer treatment on average) participated in our study. The acceptability rate was 90.9% and the feasibility rate was > 85%. We found that 85% improved PA frequency, 80% improved PA intensity, 100% improved PA time, and 50.0% achieved the recommended PA guidelines. No adverse events were reported over the duration of the intervention. Physical function improved with longer 6-minute walk distances in the intervention group (465.8 ± 74.5 m) than in the control group (398.7 ± 92.9 m) (p = 0.016). PROs scores for all participants were within the limits of the normal range. The estimated cost per participant of carrying out this intervention was USD $126.57. Our 12-week behavioral PA intervention, based on the COM-B framework, was found to be acceptable, feasible and safe in childhood cancer survivors. This study is an important step in the right direction to make exercise standard practice in pediatric oncology.

目的 我们旨在记录在 12 周内实施行为锻炼干预的可接受性(注册率)和可行性(电话接通率),并记录其对患者报告结果和身体功能的影响。本研究还介绍了实施行为锻炼干预的成本。共有 40 名参与者按照 1:1 的比例被随机分配。量身定制的行为锻炼干预措施是根据最新的儿科肿瘤学锻炼指南和 COM-B 框架制定的,以实现锻炼行为的改变。在每周的支持电话中,每周都会对处方(频率、强度、时间和类型(FITT))进行调整。对照组不接受干预。26 名男性和 14 名女性(平均年龄 13.6 岁,平均癌症治疗后 2.9 年)参与了我们的研究。接受率为 90.9%,可行性大于 85%。我们发现,85% 的人提高了锻炼频率,80% 的人提高了锻炼强度,100% 的人提高了锻炼时间,50.0% 的人达到了建议的锻炼指南。在干预过程中未出现任何不良事件。干预组的身体功能得到改善,6 分钟步行距离(465.8 ± 74.5 米)比对照组(398.7 ± 92.9 米)长(p = 0.016)。所有参与者的 PROs 分数均在正常范围内。每位参与者的干预成本估计为 126.57 美元。我们基于 COM-B 框架开展的为期 12 周的行为娱乐干预被认为在儿童癌症幸存者中是可接受的、可行的和安全的。这项研究是朝正确方向迈出的重要一步,有助于使运动成为儿科肿瘤学的标准实践。
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引用次数: 0
Arriba por la Vida Estudio: a randomized controlled trial promoting standing behavior to reduce sitting time among postmenopausal Latinas. Arriba por la Vida Estudio:一项随机对照试验,旨在促进绝经后拉丁裔妇女的站立行为,以减少久坐时间。
IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2024-10-01 Epub Date: 2024-05-09 DOI: 10.1007/s10865-024-00493-3
Gregory A Talavera, Sheila F Castañeda, Maria D Lopez-Gurrola, Ana Rebeca Alvarez-Malo, Johanne Hernandez, Isel Estrada, Umesh Narayan, Chase Ruetuer, Loki Natarajan, Dorothy D Sears, Michelle Takemoto, Ya-Ju Chang, Yesenia Avitia, Ariela Haimovich, Luis Ornelas, Andrea De La Torre, Jordan Carlson, Matthew A Allison

Postmenopausal Hispanic/Latina (N = 254) women with a body mass index (BMI) ≥ 25 kg/m2 were randomized to an intervention to reduce sitting time or a comparison condition for 12 weeks. The standing intervention group received three in-person health-counseling sessions, one home visit, and up to eight motivational interviewing calls. The heart healthy lifestyle comparison group (C) received an equal number of contact hours to discuss healthy aging. The primary outcome was 12-week change in sitting time measured via thigh-worn activPAL. Group differences in outcomes were analyzed using linear mixed-effects models. Participants had a mean age of 65 (6.5) years, preferred Spanish language (89%), BMI of 32.4 (4.8) kg/m2, and sat for an average of 540 (86) minutes/day. Significant between-group differences were observed in reductions of sitting time across the 12-week period [Mdifference (SE): C - 7.5 (9.1), SI - 71.0 (9.8), p < 0.01]. Results demonstrate that coaching models to reduce sitting are feasible and effective.

体重指数(BMI)≥ 25 kg/m2的绝经后西班牙裔/拉丁裔妇女(254 人)被随机分配到减少久坐时间的干预组或对比组,为期 12 周。站立干预组接受三次面对面的健康咨询、一次家访和多达八次的动机访谈电话。心脏健康生活方式对比组(C)接受相同次数的接触,讨论健康老龄化问题。主要结果是通过佩戴大腿的 activPAL 测量坐姿时间在 12 周内的变化。结果的组间差异采用线性混合效应模型进行分析。参与者的平均年龄为 65 (6.5) 岁,首选西班牙语(89%),体重指数为 32.4 (4.8) kg/m2,平均每天坐 540 (86) 分钟。在为期 12 周的时间里,观察到不同组之间在减少坐立时间方面存在显著差异[Mdifference (SE):C - 7.5 (9.1),SI - 71.0 (9.8),p
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引用次数: 0
Self-regulatory and self-efficacy mechanisms of weight loss in women within a community-based behavioral obesity treatment. 社区肥胖症行为治疗中女性减肥的自我调节和自我效能机制。
IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2024-10-01 Epub Date: 2024-05-18 DOI: 10.1007/s10865-024-00494-2
James J Annesi, Francine A Stewart

Given the traditional methods of treating obesity through education on controlling eating and increasing exercise have largely failed beyond the very short term, a more intensive focus on psychosocial correlates of those weight-loss behaviors has been suggested. Multiple behavioral theories incorporate self-regulation, self-efficacy, and mood; however, their interrelations and effects over both the short and long term within cognitive-behavioral obesity treatments remain unclear. Within a novel community-based program with women with obesity who had either low (n = 29) or high (n = 71) mood disturbance scores, there were significant improvements in exercise- and eating-related self-regulation and eating-related self-efficacy-primary targets of that intervention-with no significant difference in those changes by mood disturbance grouping. Changes in the summed exercise- and eating-related self-regulation scores significantly mediated relationships between changes in eating-related self-efficacy and weight (over both 6 and 12 months). There were similar results with mediation assessed via the extent exercise-related self-regulation carried over to eating-related self-regulation. In both of those models a reciprocal relationship between self-regulation and self-efficacy changes was indicated. In serial multiple mediation equations, paths of changes in exercise-related self-regulation → eating-related self-regulation → eating-related self-efficacy → weight were significant. However, paths were not significant when change in self-efficacy was entered as the predictor (initial) variable. Findings suggest viability in first focusing on exercise-related self-regulation, then eating-related self-regulation, in the course of increasing self-efficacy and probabilities for inducing enough sustained weight loss to improve obesity-associated health risks. Benefits of field-based research findings generalizing to weight-management applications were suggested.

鉴于通过控制饮食和增加运动量的教育来治疗肥胖症的传统方法在短期内基本失效,有人建议更加关注这些减肥行为的社会心理相关因素。多种行为理论包含了自我调节、自我效能和情绪;然而,这些理论之间的相互关系以及认知行为治疗肥胖症的短期和长期效果仍不清楚。在一项以社区为基础的新计划中,针对情绪障碍得分较低(29 人)或较高(71 人)的肥胖症女性,运动和饮食相关的自我调节能力以及饮食相关的自我效能(该干预的主要目标)均有显著改善,而这些变化在情绪障碍分组中并无明显差异。运动和饮食相关自我调节总分的变化对饮食相关自我效能感的变化与体重(6 个月和 12 个月)之间的关系有明显的中介作用。通过评估与运动相关的自我调节对与饮食相关的自我调节的影响程度,也得出了类似的结果。在这两个模型中,自我调节和自我效能感变化之间存在互惠关系。在序列多重中介方程中,与运动相关的自我调节→与饮食相关的自我调节→与饮食相关的自我效能→体重的变化路径是显著的。然而,当把自我效能感的变化作为预测(初始)变量时,路径并不显著。研究结果表明,在提高自我效能感的过程中,首先关注与运动相关的自我调节,然后关注与饮食相关的自我调节,这样做是可行的。建议将实地研究结果推广到体重管理应用中。
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引用次数: 0
Combining anchoring with financial incentives to increase physical activity: a randomized controlled trial among college students. 将锚定与经济激励相结合以增加体育锻炼:一项针对大学生的随机对照试验。
IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2024-10-01 Epub Date: 2024-05-05 DOI: 10.1007/s10865-024-00492-4
Chad Stecher, Ching-Hua Chen, James Codella, Sara Cloonan, James Hendler

The purpose of this study was to: (1) compare the relative efficacy of different combinations of three behavioral intervention strategies (i.e., personalized reminders, financial incentives, and anchoring) for establishing physical activity habits using an mHealth app and (2) to examine the effects of these different combined interventions on intrinsic motivation for physical activity and daily walking habit strength. A four-arm randomized controlled trial was conducted in a sample of college students (N = 161) who had a self-reported personal wellness goal of increasing their physical activity. Receiving cue-contingent financial incentives (i.e., incentives conditional on performing physical activity within ± one hour of a prespecified physical activity cue) combined with anchoring resulted in the highest daily step counts and greatest odds of temporally consistent walking during both the four-week intervention and the full eight-week study period. Cue-contingent financial incentives were also more successful at increasing physical activity and maintaining these effects post-intervention than traditional non-cue-contingent incentives. There were no differences in intrinsic motivation or habit strength between study groups at any time point. Financial incentives, particularly cue-contingent incentives, can be effectively used to support the anchoring intervention strategy for establishing physical activity habits. Moreover, mHealth apps are a feasible method for delivering the combined intervention technique of financial incentives with anchoring.

本研究的目的是:(1) 比较三种行为干预策略(即个性化提醒、经济激励和锚定)的不同组合对使用移动医疗应用程序建立体育锻炼习惯的相对效果;(2) 检验这些不同组合的干预措施对体育锻炼内在动机和日常步行习惯强度的影响。我们在自报有增加体育锻炼这一个人健康目标的大学生(161 人)中进行了一项四臂随机对照试验。在为期四周的干预和整个八周的研究期间,接受提示性经济激励(即以在预先指定的体育活动提示±一小时内进行体育活动为条件的激励)与锚定相结合的结果是,每天的步数最高,在时间上保持步行的几率最大。与传统的非提示性激励措施相比,提示性经济激励措施在增加体育锻炼以及在干预后保持这些效果方面也更为成功。在任何时间点,研究组之间的内在动机或习惯强度都没有差异。经济激励,尤其是提示性激励,可以有效地用于支持锚定干预策略,以建立体育锻炼习惯。此外,移动医疗应用程序也是提供经济激励与锚定相结合的干预技术的可行方法。
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引用次数: 0
Comparing the effectiveness of acceptance-based emotion regulation therapy and acceptance and commitment therapy on hemoglobin glycosylated and self-care in patients with type II diabetes: A randomized controlled trial. 比较基于接纳的情绪调节疗法和接纳与承诺疗法对 II 型糖尿病患者糖化血红蛋白和自我护理的效果:随机对照试验。
IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2024-10-01 Epub Date: 2024-07-31 DOI: 10.1007/s10865-024-00507-0
Elnaz Hajati, Banafsheh Gharraee, Fahimeh Fathali Lavasani, Hojjatollah Farahani, Asadollah Rajab

Type 2 diabetes (T2D) is a chronic metabolic disorder characterized by impaired glucose regulation. This study aimed to compare the effectiveness of Acceptance-Based Emotion Regulation Therapy (ABERT) and Acceptance and Commitment Therapy (ACT) on HbA1c levels and self-care behaviors in patients living with T2D. Participants were randomly assigned to ABERT (n = 16), ACT (n = 17), and control (n = 17) groups. The treatment groups received therapy based on treatment manuals, while the control group received treatment as usual (i.e., standard medical treatment). Assessments were conducted pre- and post-treatment, with a six-month follow-up, measuring HbA1c levels and self-care behaviors. Results from repeated-measures ANOVAs and post-hoc analysis demonstrated that both ABERT and ACT led to significant improvements compared to the control group. However, ABERT was more effective than ACT in reducing HbA1c levels and enhancing self-care behaviors, with sustained benefits observed in the long term. At the individual level, a higher percentage of participants in the ACT and ABERT groups experienced a global improvement in HbA1c compared to the control group during the post-test assessment. Furthermore, a higher percentage of participants in the ABERT group showed global improvement compared to both the ACT and control groups in the post-test to follow-up period. No statistically significant differences in self-care behaviors were observed between the groups at the individual level. These findings suggest that the ABERT may be a valuable intervention for individuals living with T2D, though more studies are needed to examine this subject.

2 型糖尿病(T2D)是一种以葡萄糖调节功能受损为特征的慢性代谢性疾病。本研究旨在比较基于接纳的情绪调节疗法(ABERT)和接纳与承诺疗法(ACT)对 2 型糖尿病患者 HbA1c 水平和自我护理行为的效果。参与者被随机分配到 ABERT 组(16 人)、ACT 组(17 人)和对照组(17 人)。治疗组接受基于治疗手册的治疗,而对照组则接受常规治疗(即标准医疗)。在治疗前和治疗后进行评估,并进行为期 6 个月的随访,测量 HbA1c 水平和自我护理行为。重复测量方差分析和事后分析的结果表明,与对照组相比,ABERT 和 ACT 均有显著改善。然而,在降低 HbA1c 水平和加强自我护理行为方面,ABERT 比 ACT 更有效,而且长期观察到持续的益处。在个人层面上,与对照组相比,ACT 组和 ABERT 组有更高比例的参与者在测试后评估中 HbA1c 全面改善。此外,与 ACT 组和对照组相比,ABERT 组有更高比例的参与者在测试后至随访期间的总体情况有所改善。在个体水平上,各组之间在自我护理行为方面没有发现明显的统计学差异。这些研究结果表明,ABERT 对患有 T2D 的人来说可能是一种有价值的干预措施,但还需要更多的研究来探讨这个问题。
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引用次数: 0
Differential signaling effects of blood glucose on delay discounting in individuals with and without type 1 diabetes. 血糖对 1 型糖尿病患者和非 1 型糖尿病患者延迟折现的不同信号影响。
IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2024-10-01 Epub Date: 2024-06-09 DOI: 10.1007/s10865-024-00500-7
Zheng Liu, Noel E Schaeffer, XiaoTian Wang

Based on the signaling hypothesis of blood glucose (BG), a rise in BG levels signals a positive energy budget for healthy individuals but cellular starvation for individuals with type 1 diabetes. We examined this novel prediction and its intervention implications in the context of delay discounting, the degree to which delayed rewards are discounted, and the regulatory effects of insulin ingestion. We recruited 44 adults with type 1 diabetes (mean age 30.8 years, diabetes duration 15.4 years) and recorded their BG levels. The delay discounting rate was measured using the intertemporal choice task, where participants were required to choose between sets of smaller-and-sooner (SS) and larger-and-later (LL) rewards. In addition, 82 age-matched healthy participants were recruited to provide a baseline comparison on delay discounting. Random forest analysis showed that among many diagnostic factors, delay discounting was most dominating in differentiating the individuals with type 1 diabetes from the control participants. A hierarchical linear mixed model revealed that participants with type 1 diabetes had a stronger preference for SS rewards (p < .001) after controlling for covariates. Participants who had insulin delivered before the last meal exhibited a stronger preference for LL rewards compared to after-meal delivery. In contrast, subjective measures (e.g., self-reported hunger) failed to predict the participants' actual BG levels and delay discounting rates. In sum, individuals with type 1 diabetes tend to discount future rewards excessively compared to the control participants. Pre-meal insulin ingestion was associated with a higher LL preference for future rewards.

根据血糖(BG)信号假说,血糖水平的升高对健康人来说意味着正能量预算,但对 1 型糖尿病患者来说则意味着细胞饥饿。我们结合延迟折现、延迟奖励的折现程度以及胰岛素摄入的调节作用,研究了这一新预测及其干预意义。我们招募了 44 名 1 型糖尿病成人患者(平均年龄 30.8 岁,糖尿病病程 15.4 年),并记录了他们的血糖水平。我们使用时际选择任务测量了延迟贴现率,该任务要求参与者在较小且较快的奖励(SS)和较大且较晚的奖励(LL)之间做出选择。此外,还招募了 82 名年龄匹配的健康参与者,作为延迟折现的基线比较。随机森林分析表明,在众多诊断因素中,延迟折现在区分 1 型糖尿病患者和对照组参与者方面最具优势。分层线性混合模型显示,1 型糖尿病患者对 SS 奖励有更强的偏好(p
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引用次数: 0
Factors associated with intention of HIV testing among Asian American men: a path analysis. 美国亚裔男性艾滋病检测意向的相关因素:路径分析。
IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2024-10-01 Epub Date: 2024-07-09 DOI: 10.1007/s10865-024-00502-5
Minh Luu, Regine Haardörfer, Eric Nehl, Cam Escoffery, Jessica Sales

Research has pointed to myriad cultural and socio-psychological factors associated with HIV testing, such as acculturation, social norms about HIV testing, masculinity, homonegativity, and constructs from the Theory of Planned Behavior. However, the interrelationships of these factors on the intentions of HIV testing among the population of Asian American men remains unknown. A dataset of 425 Asian American men in the U.S., collected online with convenience sampling method during 2020-2021, was analyzed to test a conceptual framework that aimed to fill this gap. Results from a path model with two endogenous variables (homonegativity and HIV testing intention) indicated that perceived social norms about HIV testing, attitude about HIV testing, and perceived HIV risk had directandindirect relationships with the intentions of HIV testing in the study population. However, social norms about HIV testing and perceived HIV risk showed stronger direct effects (standardized estimates = 0.37 and 0.34, respectively, p-value < 0.001). Additionally, we found that the relationships of these factors with HIV testing intention were also mediated by homonegativity. Findings from this study advance our understanding of pathways of associations between a host of cultural and socio-psychological factors with HIV testing intention among an understudied population - Asian American men. Our results will help inform the development of future intervention programs to increase HIV testing in this population.

研究指出了与 HIV 检测相关的众多文化和社会心理因素,如文化适应性、有关 HIV 检测的社会规范、男性气质、同性恋倾向以及计划行为理论的构建。然而,这些因素对美国亚裔男性的 HIV 检测意向的相互关系仍是未知数。为了填补这一空白,我们分析了 2020-2021 年期间通过方便抽样法在线收集的 425 名美国亚裔男性的数据集,以检验一个概念框架。带有两个内生变量(同源性和 HIV 检测意向)的路径模型结果表明,在研究人群中,感知到的 HIV 检测社会规范、对 HIV 检测的态度和感知到的 HIV 风险与 HIV 检测意向之间存在直向关系。然而,关于 HIV 检测的社会规范和感知到的 HIV 风险显示出更强的直接影响(标准化估计值分别为 0.37 和 0.34,p 值分别为 0.01 和 0.01)。
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引用次数: 0
Passive sensing of smartphone use, physical activity and sedentary behavior among adolescents and young adults during the COVID-19 pandemic. 被动感知 COVID-19 大流行期间青少年和年轻人的智能手机使用情况、体育活动和久坐行为。
IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2024-10-01 Epub Date: 2024-06-02 DOI: 10.1007/s10865-024-00499-x
Abigail M Faust, Alexandria Auerbeck, Alexandra M Lee, Ian Kim, David E Conroy

The research that links excessive screen time to adverse health outcomes is based on self-reported screen use. Few studies have documented how passively-sensed smartphone and app use relate to health behaviors like activity and sitting. Furthermore, they have not considered that daily fluctuations in smartphone/app use may have different relationships to these behaviors than a person's usual smartphone/app use. This study evaluated whether physical activity or sedentary (sitting) behavior are associated with either smartphone screen time or specific smartphone app use by adolescents and young adults during the COVID-19 pandemic. Adolescents and young adults aged 13-29 years wore activPAL4 micro activity monitors while their smartphones logged daily screen time and app use durations for nine days. Data were collected in 2020-2021 and analyzed in 2022-2023. Participants (N = 125) had a mean (SD) age of 19.7 (4.3) years. Participants' usual smartphone screen time was negatively associated with daily step counts. Daily deviations in smartphone screen time were negatively associated with daily step counts and moderate-vigorous physical activity durations. Time spent on Instagram, YouTube and, to a lesser extent, TikTok were linked with reduced activity levels. Daily sedentary behavior was not associated with usual or daily screen time. Interventions to promote physical activity during the transition into adulthood may benefit from limiting excessive smartphone screen time. Specific intervention targets could include limiting use of apps with infinite scrolling feeds algorithmically tuned to maintain user engagement, such as Instagram, YouTube and TikTok.

将过度使用屏幕时间与不良健康后果联系起来的研究都是基于自我报告的屏幕使用情况。很少有研究记录了被动感知的智能手机和应用程序使用情况与活动和坐姿等健康行为之间的关系。此外,这些研究也没有考虑到智能手机/应用程序的日常使用波动与这些行为的关系可能不同于一个人通常使用智能手机/应用程序的情况。本研究评估了在 COVID-19 大流行期间,青少年的体力活动或久坐(久坐)行为是否与智能手机屏幕时间或特定智能手机应用程序的使用有关。13-29 岁的青少年和年轻人佩戴了 activPAL4 微型活动监测器,同时他们的智能手机在九天内记录了每天的屏幕时间和应用程序使用时长。数据收集时间为 2020-2021 年,分析时间为 2022-2023 年。参与者(N = 125)的平均(标清)年龄为 19.7 (4.3) 岁。参与者通常使用智能手机的时间与每日步数呈负相关。智能手机屏幕时间的每日偏差与每日步数和中等强度体育活动持续时间呈负相关。花在 Instagram、YouTube 上的时间与活动量减少有关,花在 TikTok 上的时间较少。日常久坐行为与平时或每天的屏幕时间无关。限制过长的智能手机屏幕使用时间可能有利于在向成年过渡期间促进体育锻炼。具体的干预目标可包括限制使用通过算法调整以保持用户参与度的无限滚动信息源应用程序,如 Instagram、YouTube 和 TikTok。
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引用次数: 0
Social isolation, coping efficacy, and social well-being over time in patients with lung cancer. 肺癌患者随时间变化的社会隔离、应对能力和社会福利。
IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2024-10-01 Epub Date: 2024-07-29 DOI: 10.1007/s10865-024-00508-z
Victoria J Dunsmore, Shevaun D Neupert

Background: Little work has examined how coping efficacy and lung cancer-related social isolation relate to social well-being in the context of a patient's computed tomography (CT) scan. Researchers tested the cross-sectional relationship of social isolation and social well-being, and the longitudinal relationship between coping efficacy and social well-being before CT scans.

Method: 25 patients with lung cancer, within 6 months of their upcoming CT scan, participated. Baseline surveys collected clinical information, demographics, and social isolation; repeated monthly surveys collected coping efficacy and social well-being every 30 days until one's scan.

Results: [Cross-sectional] High levels of social isolation were associated with low levels of social well-being. [Longitudinal] On months patients reported high coping efficacy, they also reported increases in social well-being.

Conclusions: Social interventions may improve well-being among those with lung cancer as our work shows that getting and receiving support are strongly related to well-being in the time surrounding a scan.

背景:很少有研究探讨在患者进行计算机断层扫描(CT)时,应对效能和肺癌相关的社会隔离与社会幸福感之间的关系。研究人员测试了社会隔离与社会幸福感之间的横向关系,以及 CT 扫描前应对效能与社会幸福感之间的纵向关系。基线调查收集临床信息、人口统计学和社会隔离;每月重复调查收集应对效能和社会幸福感,每30天调查一次,直至扫描结束:[横向]高社会隔离度与低社会幸福感相关。[纵向]在患者报告应对效能较高的月份,他们也报告社会幸福感有所提高:我们的工作表明,获得和接受支持与扫描前后的幸福感密切相关。
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引用次数: 0
Childhood adversity, accelerated GrimAge, and associated health consequences. 童年逆境、加速衰老和相关的健康后果。
IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2024-10-01 Epub Date: 2024-05-18 DOI: 10.1007/s10865-024-00496-0
Zachary M Harvanek, Anastacia Y Kudinova, Samantha A Wong, Ke Xu, Leslie Brick, Teresa E Daniels, Carmen Marsit, Amber Burt, Rajita Sinha, Audrey R Tyrka

Childhood adversity is linked to psychological, behavioral, and physical health problems, including obesity and cardiometabolic disease. Epigenetic alterations are one pathway through which the effects of early life stress and adversity might persist into adulthood. Epigenetic mechanisms have also been proposed to explain why cardiometabolic health can vary greatly between individuals with similar Body Mass Index (BMIs). We evaluated two independent cross-sectional cohorts of adults without known medical illness, one of which explicitly recruited individuals with early life stress (ELS) and control participants (n = 195), and the other a general community sample (n = 477). In these cohorts, we examine associations between childhood adversity, epigenetic aging, and metabolic health. Childhood adversity was associated with increased GrimAge Acceleration (GAA) in both cohorts, both utilizing a dichotomous yes/no classification (both p < 0.01) as well as a continuous measure using the Childhood Trauma Questionnaire (CTQ) (both p < 0.05). Further investigation demonstrated that CTQ subscales for physical and sexual abuse (both p < 0.05) were associated with increased GAA in both cohorts, whereas physical and emotional neglect were not. In both cohorts, higher CTQ was also associated with higher BMI and increased insulin resistance (both p < 0.05). Finally, we demonstrate a moderating effect of BMI on the relationship between GAA and insulin resistance where GAA correlated with insulin resistance specifically at higher BMIs. These results, which were largely replicated between two independent cohorts, suggest that interactions between epigenetics, obesity, and metabolic health may be important mechanisms through which childhood adversity contributes to long-term physical and metabolic health effects.

童年逆境与心理、行为和身体健康问题有关,包括肥胖和心脏代谢疾病。表观遗传改变是早期生活压力和逆境的影响可能持续到成年的途径之一。表观遗传机制也被用来解释为什么体重指数(BMI)相似的个体之间的心脏代谢健康会有很大差异。我们对两个独立的无已知疾病成年人横断面队列进行了评估,其中一个队列明确招募了早期生活压力(ELS)患者和对照组参与者(n = 195),另一个队列则招募了普通社区样本(n = 477)。在这些队列中,我们研究了童年逆境、表观遗传衰老和代谢健康之间的关联。在两个队列中,童年逆境都与 GrimAge Acceleration (GAA) 的增加有关,均采用二分法是/否分类(均 p
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Journal of Behavioral Medicine
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