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Emetophobia (fear of vomiting): A meta-analysis 呕吐恐惧症(害怕呕吐):荟萃分析
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-07-19 DOI: 10.1016/j.janxdis.2025.103053
Adrian Meule, Leonie Seufert, David R. Kolar
Emetophobia refers to a specific fear of vomiting. There are only few original research studies on this condition and no study that has meta-analytically synthesized findings to describe the characteristics of persons with emetophobia. To this end, we extracted data from 31 reports and—as we examined different dependent variables—each meta-analysis was based on five to 21 samples. The pooled mean age of persons with emetophobia was 29 years but was reduced to 21–27 years when adjusting for publication bias. The pooled mean age of disorder onset was 10 years. The pooled proportion of females was 91 %. The pooled proportions of reporting fear of vomiting oneself, fear of seeing others vomit, or both, were 47 %, 11 %, and 39 %. The most common comorbid mental disorders were social anxiety disorder, depression, and generalized anxiety disorder. The pooled point prevalence of emetophobia was 5 %. Higher emetophobic symptomatology moderately related to higher disgust propensity and higher anxiety, and weakly related to higher depressive symptomatology. This meta-analysis is the first to quantify that most adults with emetophobia are in early adulthood but the disorder started in childhood, almost all are women, the primary locus of fear is vomiting oneself, the most common comorbid mental disorders are other anxiety and affective disorders, and higher emetophobic symptomatology relates to a more general tendency to be easily disgusted and to be anxious. Studies based on representative samples to obtain reliable estimates on the prevalence of emetophobia are needed.
呕吐恐惧症指的是对呕吐的特殊恐惧。关于这种情况的原始研究很少,也没有研究通过荟萃分析综合发现来描述呕吐恐惧症患者的特征。为此,我们从31份报告中提取了数据,并检查了不同的因变量,每个荟萃分析都基于5到21个样本。呕吐恐惧症患者的综合平均年龄为29岁,但经发表偏倚调整后降至21-27岁。合并平均发病年龄为10岁。女性合计比例为91% %。报告害怕自己呕吐、害怕看到别人呕吐或两者兼而有之的总比例分别为47 %、11 %和39 %。最常见的共病精神障碍是社交焦虑障碍、抑郁和广泛性焦虑障碍。呕吐恐惧症的总发生率为5. %。较高的呕吐恐惧症症状与较高的厌恶倾向和较高的焦虑中度相关,与较高的抑郁症状弱相关。这项荟萃分析首次量化了大多数有吐痰恐惧症的成年人处于成年早期,但这种疾病始于童年,几乎所有是女性,恐惧的主要来源是呕吐自己,最常见的共病精神障碍是其他焦虑和情感障碍,更高的吐痰恐惧症症状与更普遍的倾向有关,容易厌恶和焦虑。需要基于代表性样本的研究,以获得关于呕吐恐惧症患病率的可靠估计。
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引用次数: 0
Sleep disturbances predict nine-year panic disorder chronicity: The sleep-panic nexus theory with machine learning insights 睡眠障碍预测9年的慢性恐慌症:睡眠-恐慌联系理论与机器学习的见解
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-07-17 DOI: 10.1016/j.janxdis.2025.103052
Nur Hani Zainal , Natalia Van Doren

Background

Panic disorder (PD) is a chronic and impairing anxiety disorder. Individuals with more sleep disturbances might be predisposed to nine-year PD chronicity. However, linearity assumptions, small predictor sets, and analytic and design limitations have hindered optimal identification of which sleep disturbance variables are distal risk factors for PD chronicity. We thus used machine learning (ML) to predict nine-year PD chronicity using high-dimensional data.

Method

Community-dwelling adults (N = 1054) completed clinical interviews, self-reports, and seven-day sleep actigraphy at Wave 1 (W1) and the same clinical interview at Wave 2 (W2) nine years later. The baseline data comprised 43 actigraphy, self-reported sleep disturbances, clinical, and demographic variables. Seven ML models were examined. Gradient boosting machine (GBM) was the best-performing algorithm. PD chronicity was defined as the presence of a PD diagnosis at both W1 and W2.

Results

The GBM accurately predicted PD chronicity (area under the receiver operating characteristic curve [AUC] =.764). Shapley additive explanation analysis showed that the top W1 predictors of PD chronicity were comorbid major depressive disorder, low healthcare utilization, sleep medication use, lengthier wake after sleep onset, and sleep-wake circadian disruptions based on actigraphy and self-reports. Lower household income and younger age were also top predictors. Additionally, the final multivariate model was well-calibrated.

Conclusions

As proposed in our sleep-panic nexus theory, actigraphy and subjective sleep disturbances have essential prognostic value in predicting long-term PD chronicity. Harnessing ML facilitates accurate prediction by identifying complex, nonlinear relations across high-dimensional datasets, possibly improving prevention and treatment tailoring.
背景:惊恐障碍(PD)是一种慢性、损害性的焦虑障碍。睡眠障碍较多的人可能更容易患上长达9年的PD慢性疾病。然而,线性假设、小预测集以及分析和设计的局限性阻碍了最佳识别哪些睡眠障碍变量是PD慢性的远端危险因素。因此,我们使用机器学习(ML)来使用高维数据预测9年PD慢性性。方法居住在社区的成年人(N = 1054)在第一阶段(W1)完成临床访谈、自我报告和7天睡眠活动仪,9年后在第二阶段(W2)完成相同的临床访谈。基线数据包括43项活动记录、自我报告的睡眠障碍、临床和人口统计学变量。检测7个ML模型。梯度增强机(GBM)是性能最好的算法。PD慢性定义为在W1和W2均有PD诊断。结果GBM能准确预测PD的慢性性(受试者工作特征曲线下面积[AUC] =.764)。Shapley加性解释分析显示,PD慢性的前W1预测因子为共病性抑郁症、低医疗保健利用率、睡眠药物使用、睡眠开始后清醒时间延长以及基于活动图和自我报告的睡眠-觉醒昼夜节律中断。较低的家庭收入和较年轻的年龄也是主要的预测因素。此外,最终的多变量模型得到了很好的校准。结论根据睡眠-恐慌联系理论,活动描记和主观睡眠障碍在预测PD的长期慢性方面具有重要的预后价值。利用机器学习通过识别高维数据集之间复杂的非线性关系来促进准确的预测,可能会改善预防和治疗的定制。
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引用次数: 0
Bidirectional associations between PTSD symptoms and pain in daily life among women survivors of sexual assault 性侵女性幸存者PTSD症状与日常生活疼痛的双向关联
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-07-08 DOI: 10.1016/j.janxdis.2025.103051
Alexandra N. Brockdorf , Lauren E. Simpson , David DiLillo
The co-occurrence between pain and posttraumatic stress disorder (PTSD) is commonly explained by the mutual maintenance model, which proposes that each condition exacerbates the other. We tested this model by examining within-day associations between pain and PTSD using a three-week ecological momentary assessment (EMA) design. Young adult cisgender women (N = 82) who experienced sexual assault and reported PTSD symptoms and probable alcohol misuse completed three self-report surveys per day assessing momentary pain intensity and PTSD symptoms. Results from a dynamic structural equation model supported hypotheses, such that pain predicted greater PTSD symptoms four hours later and PTSD symptoms predicted greater pain. However, exploratory follow up analyses revealed differential findings by cluster, such that intrusions, negative alterations in cognition and mood, and hyperarousal each predicted subsequent pain, whereas pain predicted only later hyperarousal. Findings add nuance to our understanding of the mutual maintenance model and point to hyperarousal symptoms as a key symptom cluster linking daily pain and PTSD among women who have experienced sexual assault. Findings underscore the potential value of targeting hyperarousal symptoms in integrative interventions.
疼痛和创伤后应激障碍(PTSD)的共同发生通常用相互维持模型来解释,该模型认为每一种情况都会加剧另一种情况。我们通过使用为期三周的生态瞬时评估(EMA)设计来检查疼痛和创伤后应激障碍之间在一天内的关联来测试该模型。年轻的顺性别女性(N = 82)经历过性侵犯并报告PTSD症状和可能的酒精滥用,每天完成三次自我报告调查,评估瞬时疼痛强度和PTSD症状。动态结构方程模型的结果支持这样的假设:疼痛预示着四小时后更严重的PTSD症状,而PTSD症状预示着更大的疼痛。然而,探索性随访分析揭示了不同聚类的差异发现,例如侵入、认知和情绪的负面改变以及过度觉醒都能预测随后的疼痛,而疼痛只能预测随后的过度觉醒。研究结果增加了我们对相互维持模型的理解的细微差别,并指出,在经历过性侵犯的女性中,过度觉醒症状是将日常疼痛和创伤后应激障碍联系起来的关键症状群。研究结果强调了在综合干预中针对高觉醒症状的潜在价值。
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引用次数: 0
Understanding climate anxiety and potential impacts on pro-environment behaviours 了解气候焦虑及其对亲环境行为的潜在影响
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-06-18 DOI: 10.1016/j.janxdis.2025.103049
Zac Coates, Scott Brown, Michelle Kelly
Previous studies have identified harmful social, physical, and mental impacts due to climate change. Anxiety due to climate change or “climate anxiety” may be an adaptive or reasonable response to a real threat; however, it may also be associated with considerable functional impairment of associated behaviours. In this study, we examined the relationship between climate anxiety and pro-environment behaviours, via an online discrete choice experiment, with 374 participants recruited from prolific academic and undergraduate university recruitment program. This experiment included our discrete choice measure of pro-environment behaviours and self-report survey items examining climate anxiety, general anxiety, death anxiety, and locus of control. We found that a moderate level of climate anxiety may be optimal for making pro-environmental choices, with this group having significantly more eco-friendly choices than participants in the low or high climate anxiety groups. We also examined the relationships between climate anxiety and three other psychological concepts, locus of control, general anxiety, and death anxiety, and found that these 3 factors were positively related to climate anxiety. These findings may indicate that some additional negative mental health outcomes are associated with high levels of climate anxiety. This study provides evidence for the use of discrete choice experiments when examining pro-environment behaviours, which may allow future studies to further examine various other trade-offs or factors such as the cost that participants are willing to “pay” for an eco-friendly option.
以前的研究已经确定了气候变化对社会、身体和精神的有害影响。气候变化引起的焦虑或“气候焦虑”可能是对真实威胁的适应性或合理反应;然而,它也可能与相关行为的相当大的功能损害有关。在这项研究中,我们通过一项在线离散选择实验,研究了气候焦虑和亲环境行为之间的关系,该实验招募了374名来自多产的学术和本科大学招聘计划的参与者。本实验包括我们对亲环境行为的离散选择测量和自我报告调查项目,研究气候焦虑、一般焦虑、死亡焦虑和控制点。我们发现,适度的气候焦虑水平可能是做出亲环境选择的最佳选择,这一群体比低或高气候焦虑组的参与者有更多的环保选择。我们还研究了气候焦虑与其他三个心理概念——控制点、一般焦虑和死亡焦虑之间的关系,发现这三个因素与气候焦虑呈正相关。这些发现可能表明,一些额外的负面心理健康结果与高水平的气候焦虑有关。这项研究为在研究亲环境行为时使用离散选择实验提供了证据,这可能允许未来的研究进一步研究各种其他权衡或因素,如参与者愿意为环保选择“支付”的成本。
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引用次数: 0
Altered resting-state amygdala-cerebellar functional connectivity is associated with intolerance of uncertainty in patients with obsessive-compulsive disorder: A longitudinal study 静息状态杏仁核-小脑功能连接的改变与强迫症患者对不确定性的不耐受有关:一项纵向研究
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-06-13 DOI: 10.1016/j.janxdis.2025.103048
Qihui Guo , Rongrong Zhu , Huixia Zhou , Dongmei Wang , Xiangyang Zhang

Objectives

Intolerance of uncertainty (IU) plays an important role in the pathology of obsessive-compulsive disorder (OCD). The amygdala and anterior insula (AI) appear to be important neural correlates of IU. However, the relationship between altered resting-state functional connectivity (rsFC) and IU in OCD patients has not been reported.

Methods

This study recruited 39 patients with OCD and 45 healthy controls (HC). IU was measured using the Intolerance of Uncertainty Scale (IUS). The seed-to-voxel method was used to construct rsFC maps. Between-group differences in rsFC and their correlations with IU were analyzed. Following an eight-week psychological intervention, OCD patients underwent a second assessment. The association between rsFC changes and IU changes was investigated.

Results

OCD patients exhibited significantly higher IUS scores. Significant alterations in rsFC were observed between the left amygdala and the left cerebellum posterior lobe (CPL), as well as between the left AI and the left cuneus in OCD patients. In the OCD group, only the left amygdala - left CPL rsFC significantly correlated with IUS scores. No significant correlations were found between rsFC and IUS scores in the HC group. Longitudinal analysis revealed that changes in the left amygdala - left CPL rsFC were significantly associated with changes in IUS scores.

Conclusions

This study establishes amygdala-cerebellar rsFC as a specific neural signature of IU in patients with OCD, patterns absent in healthy controls. Moreover, the amygdala-cerebellar rsFC displayed longitudinal coupling with IU changes. These findings provide novel insights into the neural mechanisms of OCD pathology.
目的不确定性不耐受(IU)在强迫症(OCD)病理中起重要作用。杏仁核和前岛(AI)似乎是IU的重要神经关联。然而,OCD患者静息状态功能连接改变(rsFC)与IU之间的关系尚未报道。方法招募强迫症患者39例,健康对照45例。IU采用不确定度不耐受度量表(IUS)测量。采用种子到体素的方法构建rsFC地图。分析rsFC的组间差异及其与IU的相关性。经过8周的心理干预后,强迫症患者接受了第二次评估。研究了rsFC变化与IU变化之间的关系。结果socd患者IUS评分明显增高。在强迫症患者中,左杏仁核和左小脑后叶(CPL)、左AI和左楔叶之间的rsFC发生了显著变化。在强迫症组中,只有左杏仁核-左CPL rsFC与IUS评分显著相关。HC组rsFC与IUS评分无显著相关性。纵向分析显示,左杏仁核-左CPL rsFC的变化与IUS评分的变化显著相关。结论本研究确立了杏仁核-小脑rsFC是强迫症患者IU的特异性神经特征,而这种特征在健康对照组中不存在。此外,杏仁核-小脑rsFC表现出与IU变化的纵向耦合。这些发现为强迫症病理的神经机制提供了新的见解。
{"title":"Altered resting-state amygdala-cerebellar functional connectivity is associated with intolerance of uncertainty in patients with obsessive-compulsive disorder: A longitudinal study","authors":"Qihui Guo ,&nbsp;Rongrong Zhu ,&nbsp;Huixia Zhou ,&nbsp;Dongmei Wang ,&nbsp;Xiangyang Zhang","doi":"10.1016/j.janxdis.2025.103048","DOIUrl":"10.1016/j.janxdis.2025.103048","url":null,"abstract":"<div><h3>Objectives</h3><div>Intolerance of uncertainty (IU) plays an important role in the pathology of obsessive-compulsive disorder (OCD). The amygdala and anterior insula (AI) appear to be important neural correlates of IU. However, the relationship between altered resting-state functional connectivity (rsFC) and IU in OCD patients has not been reported.</div></div><div><h3>Methods</h3><div>This study recruited 39 patients with OCD and 45 healthy controls (HC). IU was measured using the Intolerance of Uncertainty Scale (IUS). The seed-to-voxel method was used to construct rsFC maps. Between-group differences in rsFC and their correlations with IU were analyzed. Following an eight-week psychological intervention, OCD patients underwent a second assessment. The association between rsFC changes and IU changes was investigated.</div></div><div><h3>Results</h3><div>OCD patients exhibited significantly higher IUS scores. Significant alterations in rsFC were observed between the left amygdala and the left cerebellum posterior lobe (CPL), as well as between the left AI and the left cuneus in OCD patients. In the OCD group, only the left amygdala - left CPL rsFC significantly correlated with IUS scores. No significant correlations were found between rsFC and IUS scores in the HC group. Longitudinal analysis revealed that changes in the left amygdala - left CPL rsFC were significantly associated with changes in IUS scores.</div></div><div><h3>Conclusions</h3><div>This study establishes amygdala-cerebellar rsFC as a specific neural signature of IU in patients with OCD, patterns absent in healthy controls. Moreover, the amygdala-cerebellar rsFC displayed longitudinal coupling with IU changes. These findings provide novel insights into the neural mechanisms of OCD pathology.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"114 ","pages":"Article 103048"},"PeriodicalIF":4.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PTSD and cognition in older adults: A systematic literature review 老年人PTSD与认知:系统文献综述
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-06-11 DOI: 10.1016/j.janxdis.2025.103047
Jasmijn E. van Rossum , Semmy Op den Camp , Renske Uiterwijk , Kay Deckers , Vasiliki Orgeta , Bernice J.A. Gulpers , Sjacko Sobczak
Post-traumatic stress disorder (PTSD) is a disabling mental health disorder affecting psychosocial functioning and quality of life. This systematic review is the first to summarize existing global literature on the relationship between PTSD and specific domains of cognitive function in the general population of older adults. We searched PsycINFO, Medline and CINAHL up until November 1st 2024. Studies were included if they were longitudinal cohort or cross-sectional studies of adults aged 60 years and over with a clinical diagnosis of PTSD or subthreshold PTSD symptoms, reporting on any domain of cognitive functioning using a standardised measure. Eighteen good or satisfactory quality articles met criteria for this review, of which three were longitudinal cohort studies and fifteen were cross-sectional studies. PTSD was associated with significant accelerated general cognitive decline and possible accelerated decline in attention and memory over time. Older adults with PTSD additionally performed significantly worse on measures of global cognitive function and memory compared to those without PTSD. For executive function results were mixed; two studies showed significant negative associations, whereas four other studies showed no significant differences between individuals with and without PTSD. Proactive screening of individuals with PTSD for cognitive decline and an additional focus of PTSD treatment on cognitive functioning are needed.
创伤后应激障碍(PTSD)是一种影响社会心理功能和生活质量的致残性精神健康障碍。本系统综述首次总结了现有的全球文献中关于PTSD与老年人特定认知功能领域之间关系的研究。我们检索了PsycINFO, Medline和CINAHL,直到2024年11月1日。研究包括对60岁及以上的成年人进行的纵向队列或横断面研究,这些成年人临床诊断为PTSD或阈下PTSD症状,使用标准化测量报告任何领域的认知功能。18篇质量良好或令人满意的文章符合本综述的标准,其中3篇为纵向队列研究,15篇为横断面研究。随着时间的推移,创伤后应激障碍与显著加速的一般认知能力下降以及可能加速的注意力和记忆力下降有关。此外,与没有PTSD的老年人相比,患有PTSD的老年人在整体认知功能和记忆方面的表现明显更差。执行功能的结果好坏参半;两项研究显示了显著的负相关,而另外四项研究显示患有和没有创伤后应激障碍的个体之间没有显著差异。需要对PTSD患者进行认知能力下降的主动筛查,并将PTSD治疗的额外重点放在认知功能上。
{"title":"PTSD and cognition in older adults: A systematic literature review","authors":"Jasmijn E. van Rossum ,&nbsp;Semmy Op den Camp ,&nbsp;Renske Uiterwijk ,&nbsp;Kay Deckers ,&nbsp;Vasiliki Orgeta ,&nbsp;Bernice J.A. Gulpers ,&nbsp;Sjacko Sobczak","doi":"10.1016/j.janxdis.2025.103047","DOIUrl":"10.1016/j.janxdis.2025.103047","url":null,"abstract":"<div><div>Post-traumatic stress disorder (PTSD) is a disabling mental health disorder affecting psychosocial functioning and quality of life. This systematic review is the first to summarize existing global literature on the relationship between PTSD and specific domains of cognitive function in the general population of older adults. We searched PsycINFO, Medline and CINAHL up until November 1st 2024. Studies were included if they were longitudinal cohort or cross-sectional studies of adults aged 60 years and over with a clinical diagnosis of PTSD or subthreshold PTSD symptoms, reporting on any domain of cognitive functioning using a standardised measure. Eighteen good or satisfactory quality articles met criteria for this review, of which three were longitudinal cohort studies and fifteen were cross-sectional studies. PTSD was associated with significant accelerated general cognitive decline and possible accelerated decline in attention and memory over time. Older adults with PTSD additionally performed significantly worse on measures of global cognitive function and memory compared to those without PTSD. For executive function results were mixed; two studies showed significant negative associations, whereas four other studies showed no significant differences between individuals with and without PTSD. Proactive screening of individuals with PTSD for cognitive decline and an additional focus of PTSD treatment on cognitive functioning are needed.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"114 ","pages":"Article 103047"},"PeriodicalIF":4.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Affective forecasting during a horror attraction: Insights into Intolerance of Uncertainty 恐怖吸引中的情感预测:对不确定性的不容忍的洞察
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-06-07 DOI: 10.1016/j.janxdis.2025.103046
L. FitzGibbon , J. Morriss , M. Clasen , S. Wake , R. Nesbit , M. Malmdorf Andersen , H.F. Dodd
In this field study, we examined for the first time how Intolerance of Uncertainty influences expectations about negative, positive, and anxiety-related affect alongside the accuracy of those expectations. The study was conducted at a horror attraction, which offers an immersive, uncertain and threat-related experience. Participants (n = 1029) completed a measure of forecasted negative, positive and anxiety-related affect prior to the experience. Immediately after the experience, they rated their actual subjective experience of each of these affective states. Additionally, confidence ratings were reported for each forecasted emotion so that metacognitive awareness of forecasting accuracy could be assessed. Results showed that participants high in IU anticipated and actually experienced less positive affect, more anxiety-related affect and more negative-affect compared to those low in IU. IU predicted bias (overestimations) in emotional forecasts for negative affect, but not for positive or anxiety-related affect. The findings demonstrate that IU may be related to affective forecasting, which has implications for transdiagnostic models and treatment of psychopathology.
在这项实地研究中,我们首次研究了不确定性不耐受如何影响对消极、积极和焦虑相关影响的预期,以及这些预期的准确性。这项研究是在一个恐怖景点进行的,它提供了一种身临其境的、不确定的、与威胁相关的体验。参与者(n = 1029)在体验之前完成了预测消极、积极和焦虑相关影响的测量。体验结束后,他们立即对每种情感状态的实际主观体验进行评分。此外,报告了每个预测情绪的信心评级,以便评估预测准确性的元认知意识。结果显示,与低IU的参与者相比,高IU的参与者预期并实际经历了更少的积极影响,更多的焦虑相关影响和更多的消极影响。IU预测了负面影响的情绪预测偏差(高估),但没有预测积极或焦虑相关的影响。研究结果表明,IU可能与情感预测有关,这对跨诊断模型和精神病理学治疗具有重要意义。
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引用次数: 0
Effectiveness of the implementation of transdiagnostic PsicAP-CV protocol for anxiety and depression in primary care: A Stepped Wedge Cluster Randomised Trial 在初级保健中实施跨诊断PsicAP-CV方案治疗焦虑和抑郁的有效性:一项阶梯楔形聚类随机试验
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-06-06 DOI: 10.1016/j.janxdis.2025.103045
Gabriel Esteller-Collado , Virtudes Pérez-Jover , Carlos Van-der Hofstadt Román , Elisabeth Malonda-Vidal , Anna Llorca-Mestre , Maider Prieto-Vila , María Carpallo-González , César González-Blanch , Paloma Ruíz-Rodríguez , Juan Antonio Moriana , Antonio Cano-Vindel , Roger Muñoz-Navarro

Introduction

Anxiety and depressive disorders represent a public health challenge, with high prevalence rates and considerable impact on quality of life (QoL) and functioning. Despite evidence supporting the efficacy of transdiagnostic cognitive behavioural therapy (TD-CBT), its implementation in settings such as primary care (PC) remains limited. The aim of this paper is to analyse the results of the PsicAP-CV, a clinical trial evaluating the effectiveness and implementation of TD-CBT in the PC setting.

Methods

The study included 320 patients from the PsicAP-CV trial, a Stepped Wedge Cluster-Randomised Trial (SW-CRT). Symptoms of anxiety and depression were assessed, as well as QoL and functioning. Linear models were used to study treatment effects on outcomes and rates of recovery, reliable recovery and deterioration were calculated.

Results

findings indicate that TD-CBT is more effective than treatment-as-usual (TAU) in reducing symptoms of anxiety and depression, as well as improving QoL and functioning. In addition, although the overall reduction in symptomatology was similar between patients who received immediate treatment (EG1) and those who received delayed treatment (EG2), there was a trend in favour of the EG1 group in the recovery indicators.

Discussion

these findings confirm the efficacy of TD-CBT for treating common mental disorders in PC and point to SW-CRT designs as a feasible and ethically sound avenue for implementing and scaling these evidence-based interventions within public health systems. They also support the broader integration of psychologists into PC, thus offering a scalable model that can significantly improve access to and outcomes of mental health care.

Trial registration

EURADICT 2013-001955-11/ISRCTN58437086.
焦虑和抑郁障碍是一项公共卫生挑战,患病率高,对生活质量(QoL)和功能有重大影响。尽管有证据支持跨诊断认知行为疗法(TD-CBT)的有效性,但其在初级保健(PC)等环境中的实施仍然有限。本文的目的是分析PsicAP-CV的结果,PsicAP-CV是一项评估TD-CBT在PC环境下的有效性和实施的临床试验。方法本研究纳入320例来自PsicAP-CV试验的患者,这是一项阶梯楔形聚类随机试验(SW-CRT)。评估焦虑和抑郁症状,以及生活质量和功能。采用线性模型研究治疗对预后的影响,并计算恢复率、可靠恢复率和恶化率。结果表明,TD-CBT在减轻焦虑和抑郁症状、改善生活质量和功能方面比常规治疗(TAU)更有效。此外,尽管在接受立即治疗(EG1)和延迟治疗(EG2)的患者之间,症状的总体减少是相似的,但在恢复指标方面,有一种有利于EG1组的趋势。讨论这些发现证实了TD-CBT治疗PC患者常见精神障碍的有效性,并指出SW-CRT设计是在公共卫生系统中实施和扩展这些循证干预措施的可行和合乎道德的途径。他们还支持将心理学家更广泛地整合到个人电脑中,从而提供了一个可扩展的模型,可以显着改善获得精神卫生保健的机会和结果。试验注册号euradict 2013-001955-11/ISRCTN58437086。
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引用次数: 0
Conditional probability of posttraumatic stress disorder in the Canadian Armed Forces: A longitudinal study 加拿大武装部队创伤后应激障碍的条件概率:一项纵向研究
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-06-02 DOI: 10.1016/j.janxdis.2025.103038
Sarah M. Kowall , Natalie Mota , Essence Perera , Nisali Muthumuni , Shay-Lee Bolton

Background

Posttraumatic stress disorder (PTSD) can be impacted by the type of trauma exposure. This is important to consider when evaluating the likelihood of having PTSD among Canadian veterans, which previous literature has not examined. The aim of this study was to: 1) Examine the prevalence and conditional probability of PTSD over a 16 year period by trauma type, differentiating by sex, and 2) Explore this relationship by worst trauma type.

Methods

We examined the prevalence of PTSD by sex among those with any exposure to 26 traumatic events, and used logistic regressions to examine trauma type and PTSD. The conditional probability of having PTSD over the 16-year follow-up period (2002–2018) and in the past year was calculated using population attributable fractions (PAFs). Identical analyses were used to examine the conditional probability of PTSD related to a self-reported ‘worst event’.

Results

Over the 16-year follow-up, we found that males showed higher conditional likelihood of developing PTSD from exposure to sexual trauma while females showed a higher conditional likelihood of developing PTSD from exposure to an accidentrelated trauma. For the probability of PTSD conditional on the worst event, accidentrelated or sexual trauma in females, and sexual and deployment-related trauma in males showed the highest PAF and strongest relationship.

Conclusion

This research supports differences in PTSD prevalence depending on the type of traumatic exposure. Importantly, different patterns of conditional probability of PTSD emerged by sex. These findings can provide important information for mental health providers within the military treating multiple traumas.
背景创伤后应激障碍(PTSD)可能受到创伤暴露类型的影响。在评估加拿大退伍军人患创伤后应激障碍的可能性时,这一点很重要,因为以前的文献没有研究过这一点。本研究的目的是:1)根据创伤类型和性别区分,检查16年来PTSD的患病率和条件概率;2)通过最严重的创伤类型探讨这种关系。方法对26例创伤性事件暴露者的PTSD患病率进行性别分析,并采用logistic回归分析创伤类型与PTSD的关系。使用人口归因分数(paf)计算16年随访期间(2002-2018年)和过去一年患创伤后应激障碍的条件概率。同样的分析被用于检查与自我报告的“最坏事件”相关的PTSD的条件概率。结果在16年的随访中,我们发现男性暴露于性创伤后患PTSD的条件可能性更高,而女性暴露于事故相关的创伤后患PTSD的条件可能性更高。对于以最坏事件为条件的创伤后应激障碍的概率,女性与事故或性创伤有关,男性与性和部署有关的创伤显示最高的PAF和最强的关系。结论本研究支持创伤暴露类型对PTSD患病率的影响。重要的是,PTSD的条件概率模式因性别而异。这些发现可以为军队中治疗多重创伤的心理健康提供者提供重要信息。
{"title":"Conditional probability of posttraumatic stress disorder in the Canadian Armed Forces: A longitudinal study","authors":"Sarah M. Kowall ,&nbsp;Natalie Mota ,&nbsp;Essence Perera ,&nbsp;Nisali Muthumuni ,&nbsp;Shay-Lee Bolton","doi":"10.1016/j.janxdis.2025.103038","DOIUrl":"10.1016/j.janxdis.2025.103038","url":null,"abstract":"<div><h3>Background</h3><div>Posttraumatic stress disorder (PTSD) can be impacted by the type of trauma exposure. This is important to consider when evaluating the likelihood of having PTSD among Canadian veterans, which previous literature has not examined. The aim of this study was to: 1) Examine the prevalence and conditional probability of PTSD over a 16 year period by trauma type, differentiating by sex, and 2) Explore this relationship by worst trauma type.</div></div><div><h3>Methods</h3><div>We examined the prevalence of PTSD by sex among those with any exposure to 26 traumatic events, and used logistic regressions to examine trauma type and PTSD. The conditional probability of having PTSD over the 16-year follow-up period (2002–2018) and in the past year was calculated using population attributable fractions (PAFs). Identical analyses were used to examine the conditional probability of PTSD related to a self-reported ‘worst event’.</div></div><div><h3>Results</h3><div>Over the 16-year follow-up, we found that males showed higher conditional likelihood of developing PTSD from exposure to sexual trauma while females showed a higher conditional likelihood of developing PTSD from exposure to an accidentrelated trauma. For the probability of PTSD conditional on the worst event, accidentrelated or sexual trauma in females, and sexual and deployment-related trauma in males showed the highest PAF and strongest relationship.</div></div><div><h3>Conclusion</h3><div>This research supports differences in PTSD prevalence depending on the type of traumatic exposure. Importantly, different patterns of conditional probability of PTSD emerged by sex. These findings can provide important information for mental health providers within the military treating multiple traumas.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"114 ","pages":"Article 103038"},"PeriodicalIF":4.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FOMO’s apprehension of missing out and constant connection desire dimensions differentially correlate with problematic smartphone and social media use, but not with depression or generalized anxiety FOMO对错过和持续联系欲望维度的担忧与智能手机和社交媒体的问题使用存在差异,但与抑郁或广泛性焦虑无关
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-05-28 DOI: 10.1016/j.janxdis.2025.103037
Jon D. Elhai , Silvia Casale , Rachel A. Bond
The fear of missing out (FOMO) involves an apprehension of missing out on rewarding experiences, and a desire to continually stay connected with people. However, this two-dimension conceptualization of FOMO has not been properly empirically examined. We examined this two-factor model using confirmatory factor analysis in 326 American college students, and 433 Italian participants recruited through social media. We discovered that in both samples, the two-factor model fit well; e.g., the US sample’s comparative fit index (CFI) = .990, Tucker-Lewis Index (TLI) = .985; Italian sample’s CFI = .941, TLI = .917. The two-factor model fit significantly better than a one-factor model in both samples (ps<.001) (though magnitude of differences was small, with CFI differences ranging from .001–.007). In both samples, problematic social media use severity was more correlated (ps<.001) with FOMO’s constant connection desire factor (US sample r = .749; Italian sample r = .845) than apprehension of missing out factor (US sample r = .622; Italian sample r = .500). In the American sample, problematic smartphone use severity also correlated more (p < .001) with constant connection desire (r = .668) than apprehension of missing out (r = .587). However, in the American sample depression severity correlated equally (ps>.05) with FOMO’s constant connection desire (r = .466) and apprehension of missing out (r = .503) factors; generalized anxiety disorder symptoms also equally correlated (ps>.05) with FOMO’s constant connection desire (r = .470) and apprehension of missing out (r = .508). We discuss implications of our findings for measurement of FOMO, and FOMO’s relationship with problematic Internet use and negative affectivity.
错失恐惧(FOMO)包括对错过有益经历的担忧,以及与人保持联系的渴望。然而,这种FOMO的二维概念化尚未得到适当的实证检验。我们使用验证性因子分析对326名美国大学生和433名通过社交媒体招募的意大利参与者进行了检验。我们发现,在两个样本中,双因素模型拟合良好;例如,美国样本的比较拟合指数(CFI) = 。990, Tucker-Lewis指数(TLI) = .985;意大利样品的CFI = 。941, tli = .917。在两个样本中,双因素模型的拟合效果明显优于单因素模型(ps<.001)(尽管差异幅度很小,CFI差异范围为0.001 - 0.007)。在两个样本中,有问题的社交媒体使用严重程度与FOMO的恒定连接欲望因子(美国样本r = .749;意大利样本r = .845)大于对遗漏因子的理解(美国样本r = .622;意大利样本r = .500)。在美国的样本中,有问题的智能手机使用严重程度与持续的连接欲望(r = .668)的相关性(p <; .001)也高于对错过的担忧(r = .587)。然而,在美国样本中,抑郁严重程度与FOMO的持续连接欲望(r = .466)和错过恐惧(r = .503)因素同等相关(ps> 0.05);广泛性焦虑障碍症状与FOMO的持续联系欲望(r = .470)和对错过的恐惧(r = .508)也同样相关(ps> 0.05)。我们讨论了我们的研究结果对FOMO测量的影响,以及FOMO与有问题的互联网使用和消极情感的关系。
{"title":"FOMO’s apprehension of missing out and constant connection desire dimensions differentially correlate with problematic smartphone and social media use, but not with depression or generalized anxiety","authors":"Jon D. Elhai ,&nbsp;Silvia Casale ,&nbsp;Rachel A. Bond","doi":"10.1016/j.janxdis.2025.103037","DOIUrl":"10.1016/j.janxdis.2025.103037","url":null,"abstract":"<div><div>The fear of missing out (FOMO) involves an apprehension of missing out on rewarding experiences, and a desire to continually stay connected with people. However, this two-dimension conceptualization of FOMO has not been properly empirically examined. We examined this two-factor model using confirmatory factor analysis in 326 American college students, and 433 Italian participants recruited through social media. We discovered that in both samples, the two-factor model fit well; e.g., the US sample’s comparative fit index (CFI) = .990, Tucker-Lewis Index (TLI) = .985; Italian sample’s CFI = .941, TLI = .917. The two-factor model fit significantly better than a one-factor model in both samples (ps&lt;.001) (though magnitude of differences was small, with CFI differences ranging from .001–.007). In both samples, problematic social media use severity was more correlated (ps&lt;.001) with FOMO’s constant connection desire factor (US sample r = .749; Italian sample r = .845) than apprehension of missing out factor (US sample r = .622; Italian sample r = .500). In the American sample, problematic smartphone use severity also correlated more (p &lt; .001) with constant connection desire (r = .668) than apprehension of missing out (r = .587). However, in the American sample depression severity correlated equally (ps&gt;.05) with FOMO’s constant connection desire (r = .466) and apprehension of missing out (r = .503) factors; generalized anxiety disorder symptoms also equally correlated (ps&gt;.05) with FOMO’s constant connection desire (r = .470) and apprehension of missing out (r = .508). We discuss implications of our findings for measurement of FOMO, and FOMO’s relationship with problematic Internet use and negative affectivity.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"114 ","pages":"Article 103037"},"PeriodicalIF":4.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144196295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Anxiety Disorders
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