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Interplay of serum BDNF levels and childhood adversity in predicting earlier-onset post-traumatic stress disorder: A two-year longitudinal study 血清 BDNF 水平和童年逆境在预测早期创伤后应激障碍方面的相互作用:一项为期两年的纵向研究。
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-12 DOI: 10.1016/j.janxdis.2024.102943
Jae-Min Kim , Hee-Ju Kang , Ju-Wan Kim , Ju-Yeon Lee , Hyunseok Jang , Jung-Chul Kim , Sung-Wan Kim , Il-Seon Shin
This longitudinal study explored the intricate relationships between serum Brain-Derived Neurotrophic Factor (sBDNF) levels, exposure to childhood adversities, and the subsequent development of Post-Traumatic Stress Disorder (PTSD), distinguishing between earlier- and delayed-onset forms over a two-year follow-up period in individuals sustaining physical injuries. We recruited patients presenting with moderate to severe physical injuries at a trauma center, conducting baseline assessments of sBDNF levels and childhood adversities through the Adverse Childhood Experiences (ACE) questionnaire. Additionally, detailed socio-demographic and clinical data were compiled. The Clinician-Administered PTSD Scale for DSM-5 was employed to diagnose PTSD at 3, 6, 12, and 24 months post-injury. Binary and multinomial logistic regression analyses were applied to elucidate the interactions between sBDNF levels, childhood adversities, and PTSD onset patterns. Among 895 participants, PTSD was diagnosed in 107 individuals (11.9 %), with 76 (8.4 %) exhibiting symptoms indicative of earlier-onset PTSD and 31 (3.5 %) demonstrating delayed-onset PTSD. Significantly, lower sBDNF levels were associated with a higher risk of earlier-onset PTSD specifically in the context of childhood adversities. This association was not observed in individuals without childhood adversities or in those with delayed-onset PTSD. The findings suggest a complex and critical interplay between neurobiological factors, specifically sBDNF levels, and early life adversities in influencing the timing of PTSD onset, potentially deepening the understanding of PTSD etiology.
这项纵向研究探讨了血清脑源性神经营养因子(sBDNF)水平、童年逆境经历与创伤后应激障碍(PTSD)后续发展之间错综复杂的关系,并在两年的随访期内对肢体损伤患者的早期和延迟发病形式进行了区分。我们在一家创伤中心招募了中度至重度肢体损伤患者,通过童年逆境经历(ACE)问卷对他们的sBDNF水平和童年逆境经历进行了基线评估。此外,还收集了详细的社会人口学和临床数据。在受伤后 3、6、12 和 24 个月时,采用 DSM-5 临床医师管理创伤后应激障碍量表诊断创伤后应激障碍。应用二元和多叉逻辑回归分析来阐明 sBDNF 水平、童年逆境和创伤后应激障碍发病模式之间的相互作用。在 895 名参与者中,有 107 人(11.9%)被诊断为创伤后应激障碍,其中 76 人(8.4%)表现出较早发病的创伤后应激障碍症状,31 人(3.5%)表现出延迟发病的创伤后应激障碍症状。值得注意的是,较低的sBDNF水平与较高的早发性创伤后应激障碍风险有关,特别是在童年逆境中。而在没有童年逆境的人或延迟发病的创伤后应激障碍患者中,则没有观察到这种关联。研究结果表明,神经生物学因素(特别是sBDNF水平)与早期生活逆境之间存在着复杂而关键的相互作用,影响着创伤后应激障碍的发病时间,从而有可能加深对创伤后应激障碍病因的理解。
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引用次数: 0
Intensive treatments for children and adolescents with anxiety or obsessive-compulsive disorders: A systematic review and meta-analysis 针对患有焦虑症或强迫症的儿童和青少年的强化治疗:系统回顾和荟萃分析。
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-02 DOI: 10.1016/j.janxdis.2024.102940
Colin O.W. Ganzevoort , Lidewij H. Wolters , Rianne Hornstra , Caitlin M. Grieve , Davíð R.M.A. Højgaard , Gudmundur A. Skarphedinsson , Bernhard Weidle , Polly Waite , Lizél-Antoinette Bertie , Mark Tomlinson , Maaike H. Nauta
Anxiety and obsessive-compulsive disorders have a significant negative impact on youth. Cognitive behavioural therapy (CBT) is recommended and established as effective first-step treatment, but persistent symptoms and non-response are common. Intensive psychological treatments deliver more or longer sessions over a shorter time span, with fewer session gaps. However, an understanding of their effectiveness, characteristics, acceptability, and feasibility is lacking. Systematically searching five databases yielded four controlled and 36 uncontrolled studies (N=2707) involving youth with primary anxiety or obsessive-compulsive disorders, many of whom received prior treatments. Intensive treatments were acceptable and feasible, with low drop-out rates. Between-group analyses compared intensive treatment with standard treatment (k = 2) or waitlist (k = 2), revealing no significant post-treatment differences in symptom severity or remission. Uncontrolled within-group analyses of intensive treatments showed large improvements from pre- to post-treatment in symptoms (k = 47), remission (k = 17), impairment (k = 22), functioning (k = 5), and quality of life (k = 2), with larger effects at follow-ups. Intensive treatments show promise for youth with anxiety or obsessive-compulsive disorders by potentially offering high treatment completion rates and comparable outcomes to standard CBT, aiding earlier recovery and reducing overall suffering. This systematic review/meta-analysis provides a comprehensive overview of intensive treatments, their theoretical considerations, and empirical findings. Future RCTs should compare the effectiveness of standard and intensive treatments and identify optimal populations for their use.
焦虑症和强迫症对青少年有很大的负面影响。认知行为疗法(CBT)作为有效的第一步治疗方法得到推荐和认可,但症状持续和无反应的情况很常见。强化心理治疗在较短的时间跨度内提供更多或更长的疗程,减少疗程间隔。然而,人们对其有效性、特点、可接受性和可行性还缺乏了解。通过对五个数据库进行系统检索,我们获得了四项对照研究和 36 项非对照研究(N=2707),涉及患有原发性焦虑症或强迫症的青少年,其中许多人之前接受过治疗。强化治疗是可以接受的,也是可行的,辍学率较低。组间分析比较了强化治疗与标准治疗(k = 2)或候补治疗(k = 2),结果显示治疗后症状严重程度或缓解程度没有显著差异。强化治疗的非对照组内分析显示,从治疗前到治疗后,症状(k = 47)、缓解(k = 17)、损伤(k = 22)、功能(k = 5)和生活质量(k = 2)都有很大改善,随访效果更大。强化治疗为患有焦虑症或强迫症的青少年带来了希望,因为它有可能提供较高的治疗完成率和与标准 CBT 相当的疗效,帮助患者早日康复并减少整体痛苦。本系统综述/元分析全面概述了强化治疗、其理论考虑因素和实证研究结果。未来的研究性试验应比较标准治疗和强化治疗的有效性,并确定使用强化治疗的最佳人群。
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引用次数: 0
Daily stress and emotions in relation to fear of negative and positive evaluation 与害怕负面和正面评价有关的日常压力和情绪
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-25 DOI: 10.1016/j.janxdis.2024.102932
Julia Reichenberger, Ann-Kathrin Arend, Jens Blechert
Fear of negative (FNE) and positive (FPE) evaluation constitute distinct components of social anxiety and relate to altered affectivity. It is unclear whether individuals with strong FNE/FPE overreact to social stressors only or to more unspecific ones as well. The present set of three studies (n = 109 and n = 97 healthy individuals in study 1/2, n = 49 patients with social anxiety disorder in study 3) assessed whether reactivity to various daily stressors and non-specific momentary stress/emotions assessed through ecological momentary assessment depend on individuals’ level of FPE/FNE. Almost all relationships with FPE/FNE were explained by depressive symptoms, except for a unique association of FNE with reactivity to stressors from the distant social network. Relationships of FNE with momentary global stress and emotions were mixed, but again explained by depressive symptoms. More depressive symptoms were associated with higher stress, negative affect, and most stressor types as well as lower positive affect in all studies. These results show that for social stressors from the distant social network, FNE has explanatory power. They further document the role of depressive affect for reactivity to a wide range of everyday stressors and question the need for specific instruments assessing FPE/FNE unless stressors are explicitly social-evaluative in nature.
对负面评价(FNE)和正面评价(FPE)的恐惧构成了社交焦虑的不同组成部分,并与情感改变有关。目前还不清楚的是,具有强烈 FNE/FPE 的个体是只对社会压力做出过度反应,还是也对更多非特定的压力做出过度反应。本组的三项研究(研究 1/2:n = 109 和 n = 97 名健康人;研究 3:n = 49 名社交焦虑症患者)评估了对各种日常压力源和通过生态瞬间评估的非特异性瞬间压力/情绪的反应是否取决于个人的 FPE/FNE 水平。除了 FNE 与对来自远方社交网络的压力源的反应性有独特联系外,几乎所有与 FPE/FNE 的关系都可以用抑郁症状来解释。FNE与瞬间整体压力和情绪的关系不一,但同样可以用抑郁症状来解释。在所有研究中,更多的抑郁症状与更大的压力、消极情绪、大多数压力类型以及更低的积极情绪相关。这些结果表明,对于来自遥远社交网络的社会压力,FNE 具有解释力。他们还进一步证明了抑郁情绪对各种日常压力反应的作用,并质疑除非压力具有明确的社会评价性质,否则是否需要特定的工具来评估FPE/FNE。
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引用次数: 0
Fear of positive evaluation and social affiliation in social anxiety disorder and major depression 社交焦虑症和重度抑郁症患者对积极评价和社会归属感的恐惧
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-24 DOI: 10.1016/j.janxdis.2024.102931
Madeleine Rassaby , Isabella G. Spaulding , Charles T. Taylor
Fear of positive evaluation (FPE) is posited as a core feature of social anxiety disorder (SAD); however, little is known about its role in interpersonal functioning. We examined relationships between FPE and responses to a standardized social affiliation paradigm designed to facilitate positive social connection with an unacquainted conversation partner (trained confederate). The sample included adults with SAD (N = 52), major depressive disorder (MDD; N = 23), comorbid SAD and MDD (N = 36), and non-psychiatric controls (N = 33). Participants completed measures assessing FPE, affect, safety behaviors, and desire for future interaction. Confederates and observers rated participant behavior and their own desire for future interaction. FPE was most elevated in the SAD and comorbid groups, followed by the MDD group, and then non-psychiatric controls. In the full sample, FPE was associated with greater self-reported anxiety and safety behavior use, lower self-reported positive affect and desire for future interaction, lower observer-rated desire for future interaction and approach behaviors, and greater observer-rated anxious behaviors. Within-group correlations revealed that associations were weaker in the SAD only and comorbid groups (cf. control and MDD only groups); however, post-hoc moderation analyses indicated that the relationships between FPE and the outcomes of interest largely held across varying levels of social anxiety and depression severity. Findings underscore the potential role of FPE as a transdiagnostic factor relevant to understanding interpersonal functioning in social anxiety and depression.
害怕积极评价(FPE)被认为是社交焦虑症(SAD)的一个核心特征;然而,人们对它在人际功能中的作用却知之甚少。我们研究了 FPE 与标准化社会归属范式反应之间的关系,该范式旨在促进与不熟悉的对话伙伴(训练有素的知己)建立积极的社会联系。样本包括患有 SAD(52 人)、重度抑郁障碍(MDD;23 人)、SAD 和 MDD 合并症(36 人)的成年人,以及非精神病对照组(33 人)。参与者完成了对 FPE、情感、安全行为和未来互动愿望的评估。同盟者和观察者对参与者的行为和他们自己对未来互动的渴望进行评分。FPE 在 SAD 和合并症组中升高幅度最大,其次是 MDD 组,然后是非精神病对照组。在全部样本中,FPE 与以下因素相关:自我报告的焦虑和安全行为使用率较高;自我报告的积极情绪和未来互动愿望较低;观察者评定的未来互动愿望和接近行为较低;观察者评定的焦虑行为较高。组内相关性显示,仅有 SAD 组和合并组(与对照组和仅有 MDD 组相比)的相关性较弱;然而,事后调节分析表明,在不同程度的社交焦虑和抑郁严重性中,FPE 与相关结果之间的关系基本保持不变。研究结果强调了 FPE 作为一种跨诊断因素在了解社交焦虑和抑郁的人际功能方面的潜在作用。
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引用次数: 0
A within-person test of the metacognitive model: Daily dynamics between metacognitive beliefs, metacognitive strategies, and negative affect 元认知模型的人际测试:元认知信念、元认知策略和消极情绪之间的日常动态关系
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-18 DOI: 10.1016/j.janxdis.2024.102930
Julia B. Cano-López , Frederick Anyan , Esperanza García-Sancho , Henrik Nordahl , José M. Salguero

The metacognitive model of psychological disorders highlights that emotional distress is maintained by metacognitive strategies, which are related to underlying metacognitive beliefs. Considerable empirical evidence has supported the role of metacognitions in psychopathology, but few studies have examined the suggested links between metacognitive beliefs, metacognitive strategies, and symptoms within individuals. Within-person effects provide better empirical tests of theory-based hypotheses derived from clinical models as they relate to change at the individual level. Thus, the current study sought to test central predictions from the metacognitive model at the within-person level using Dynamic Structural Equation Modelling (DSEM). A sample of 222 participants gathered at convenience participated in a 26-day long assessment period where they reported daily measures of metacognitive beliefs, metacognitive strategies, and negative affect. Temporal precedence and bidirectional relations between the variables, and the possible day-to-day and within days mediation role of metacognitive strategies between metacognitive beliefs and negative affect, were tested. When controlling for previous days effects, metacognitions and negative affect (but not metacognitive strategies) predicted each other the next day, showing a reciprocal relationship. However, metacognitive strategies were significant mediators between metacognitions and negative affect within days and day-to-day. Implications and future directions based on these findings are discussed.

心理障碍的元认知模型强调,情绪困扰是由元认知策略维持的,而元认知策略与潜在的元认知信念有关。大量经验证据支持元认知在心理病理学中的作用,但很少有研究对元认知信念、元认知策略和个人症状之间的联系进行研究。个人内部效应可以更好地对临床模型中基于理论的假设进行实证检验,因为这些假设与个人层面的变化有关。因此,本研究试图利用动态结构方程建模(DSEM)在个体内部水平检验元认知模型的核心预测。222名参与者参加了为期26天的评估,他们每天报告元认知信念、元认知策略和消极情绪的测量结果。测试了各变量之间的时间先后关系和双向关系,以及元认知策略在元认知信念和消极情绪之间可能发挥的日间和日内中介作用。在控制了前几天的影响后,元认知和消极情绪(而不是元认知策略)在第二天相互预测,显示出互为因果的关系。然而,元认知策略在元认知和消极情绪之间起着重要的中介作用。本文讨论了基于这些发现的影响和未来发展方向。
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引用次数: 0
Cross-cultural validation of the BFOE model: Best practices and future directions for psychometric evaluation of the Fear of positive evaluation scale – Insights from a Dutch translation BFOE 模型的跨文化验证:恐惧积极评价量表心理测量评估的最佳实践和未来方向--荷兰语翻译的启示
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-18 DOI: 10.1016/j.janxdis.2024.102929
Wolf-Gero Lange , Ashley N. Howell , Justin W. Weeks
The Bivalent Fear of Evaluation (BFOE) model suggests that Social Anxiety Disorder is not only characterized by fear of negative evaluation (FNE), but also fear of positive evaluation (FPE). While FNE has been firmly established, research of the latter is accumulating. To evaluate the role of the BFOE Model, and particularly FPE, validated measures such as the Fear of Positive Evaluation Scale (FPES) are pivotal. Yet, validation of psychometric properties is often at stake or neglected when translating a scale to other languages. This hampers cross-cultural evaluation of questionnaires and related concepts considerably, including the BFOE Model. To illustrate, a freely available, but not validated Dutch version of the FPES was completed, along with other measures by 354 community participants from the Netherlands and Belgium in an online study. The Dutch FPES showed excellent convergent and discriminant validity. In addition, it explained additional variance in social anxiety above and beyond FNE. These results as well as those from the factor analyses were highly comparable with those deriving from evaluations of the original English version. In conclusion, the Dutch FPES showed excellent psychometric properties and is fit for further exploring consistency or differences in the BFOE model across cultures. Based on this case, practice guidelines for international use and validation of measures are discussed, and recommendations are provided.
二元评价恐惧(BFOE)模型表明,社交焦虑症不仅表现为害怕负面评价(FNE),还表现为害怕正面评价(FPE)。虽然 FNE 已被牢固确立,但有关后者的研究却在不断积累。要评估 BFOE 模型的作用,尤其是 FPE 的作用,诸如 "害怕积极评价量表"(FPES)等经过验证的测量方法至关重要。然而,在将量表翻译成其他语言时,心理测量特性的验证往往受到威胁或被忽视。这极大地阻碍了对问卷和相关概念(包括 BFOE 模型)的跨文化评估。为了说明这一点,在一项在线研究中,来自荷兰和比利时的 354 名社区参与者完成了免费提供但未经验证的荷兰语版 FPES 以及其他测量方法。荷兰语 FPES 显示出极佳的收敛性和区分性。此外,它还能解释 FNE 以外的社交焦虑差异。这些结果以及因子分析结果与原始英语版本的评估结果具有很高的可比性。总之,荷兰语 FPES 显示了出色的心理测量特性,适合进一步探索不同文化背景下 BFOE 模型的一致性或差异性。在此案例的基础上,讨论了国际使用和验证测量方法的实践指南,并提出了相关建议。
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引用次数: 0
Cognitive behavioral group therapy for social anxiety disorder – A critical review of methodological designs 治疗社交焦虑症的认知行为团体疗法--方法设计评述
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-13 DOI: 10.1016/j.janxdis.2024.102928
Julie A. Wojtaszek , Ellen I. Koch , Eamonn Arble , Tamara M. Loverich

Social anxiety disorder (SAD) is highly prevalent with significant lifetime impacts, especially when left untreated. Cognitive behavioral therapy is the current gold standard treatment with successful patient outcomes. Cognitive behavioral group therapy (CBGT) is one form that provides unique benefits to participants including normalization of symptoms and social support, as well as providing increased access to treatment at a lower per-session cost. Research on this mode of treatment has been ongoing for over 20 years, but we still have much to learn about its overall efficacy. The goals of this critical review were to summarize and evaluate the most current research, including an analysis of the overall methodological design quality, and provide recommendations for the enhancement of future studies based on best practices. Recent studies included some best practice design elements used in measuring efficacy such as the use of comparison groups, masking procedures, fidelity assessments, and consideration of clinical significance in outcomes. However, many gaps exist such as a lack of consensus around measures and therapy manuals, as well as baseline competencies of facilitators. Future studies should consider incorporating additional best practice elements aligning with study goals to strengthen designs and provide the field with even more confidence in this mode of treatment.

社交焦虑症(SAD)的发病率很高,对患者的一生都有重大影响,尤其是在未经治疗的情况下。认知行为疗法是目前最有效的治疗方法,对患者的治疗效果非常明显。认知行为团体疗法(CBGT)是一种能为参与者带来独特益处的疗法,包括症状正常化和社会支持,以及以较低的每次治疗费用提供更多的治疗机会。对这种治疗模式的研究已经持续了 20 多年,但我们对其整体疗效仍有很多需要了解的地方。本评论旨在总结和评估当前的最新研究,包括对整体方法设计质量的分析,并根据最佳实践为今后的研究提供改进建议。近期的研究包括一些用于衡量疗效的最佳实践设计元素,如使用对比组、掩蔽程序、保真度评估以及考虑结果的临床意义。然而,研究中还存在许多不足,例如在测量方法和治疗手册以及促进者的基线能力方面缺乏共识。未来的研究应考虑纳入更多与研究目标相一致的最佳实践要素,以加强设计,使该领域对这种治疗模式更有信心。
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引用次数: 0
Dating in social anxiety disorder: A daily diary study 社交焦虑症患者的约会:每日日记研究
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-12 DOI: 10.1016/j.janxdis.2024.102927
Talia Shechter Strulov , Idan M. Aderka

Romantic relationships are vital for health, well-being and quality of life, and an increasing percentage of romantic relations begin via use of dating apps and subsequently progress to dates. In the present study we examined dating application use and dates among individuals with SAD (n = 54) and without SAD (n = 54). Our sample included young adults (age range 18 to 33) who were not in a romantic relationship at the time of the study. For both individuals with SAD and without SAD, half of the participants were men, and half were women. We used a daily diary measurement in which participants reported on their dating application use and dates, as well as on concomitant emotions and perceptions for 21 consecutive days. We found that individuals with and without SAD did not differ in the frequency/duration of application use nor in the number of dates attended. However, individuals with SAD experienced dates as more negative compared to individuals without SAD (Cohen’s d = 0.65). Interestingly, individuals with SAD did not significantly differ in their experience of dates as positive compared to individuals without SAD. Moreover, use of dating applications/going on dates were associated with increases in shame (Cohen’s d = 0.59) and embarrassment (Cohen’s d = 0.45) and this was found to a greater extent among individuals with SAD compared to individuals without SAD (Cohen’s d = 0.50, 0.39 for shame and embarrassment respectively). Findings are discussed in the context of cognitive behavioral models of SAD and implications for treatment are considered.

恋爱关系对健康、幸福和生活质量至关重要,越来越多的恋爱关系开始于使用约会应用程序,随后发展为约会。在本研究中,我们调查了患有 SAD(54 人)和未患有 SAD(54 人)的人使用约会应用程序和约会的情况。我们的样本包括在研究期间没有恋爱关系的年轻人(年龄在 18 到 33 岁之间)。在患有 SAD 和未患有 SAD 的人群中,男性和女性各占一半。我们采用每日日记的测量方法,让参与者连续 21 天报告其约会应用程序的使用情况和约会日期,以及伴随的情绪和看法。我们发现,患有和未患有 SAD 的人在使用应用程序的频率/持续时间和参加约会的次数上没有差异。然而,与没有 SAD 的人相比,有 SAD 的人对约会的体验更消极(Cohen's d = 0.65)。有趣的是,与没有 SAD 的人相比,有 SAD 的人对约会的积极体验没有明显差异。此外,使用约会应用程序/进行约会与羞耻感(科恩氏 d = 0.59)和尴尬感(科恩氏 d = 0.45)的增加有关,与没有 SAD 的人相比,SAD 患者的羞耻感和尴尬感增加的程度更大(羞耻感和尴尬感的科恩氏 d 分别为 0.50 和 0.39)。研究结果将在 SAD 认知行为模型的背景下进行讨论,并考虑对治疗的影响。
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引用次数: 0
Group metacognitive therapy for children and adolescents with anxiety and depression: A preliminary trial and test of proposed mechanisms 针对患有焦虑症和抑郁症的儿童和青少年的团体元认知疗法:初步试验和拟议机制测试
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-10 DOI: 10.1016/j.janxdis.2024.102926
Anne Thingbak , Adrian Wells , Mia Skytte O’Toole
Preliminary research supports the feasibility of metacognitive therapy (MCT) in children with generalized anxiety, but the effectiveness of MCT in treating children with other anxiety and depressive disorders largely remains unknown. The purpose of this study was to investigate the effects associated with MCT in targeting symptoms of anxiety and depression in children and adolescents and to investigate mechanisms proposed by the metacognitive model. Ninety-seven participants aged 10–17 years (M = 12.9 ± 1.9, 82.5 % females) with anxiety and depressive disorders received eight sessions of group MCT. Participants were diagnostically assessed at pre- and post-treatment and completed symptom and process measures before, during, and after treatment, and again at three- and six-month follow-up. Multilevel models were conducted to investigate treatment-related and mediation effects. Results showed large reductions in total symptoms following treatment (d = 1.28). These reductions were associated with, and temporally preceded by changes in cognitive attentional syndrome (CAS), metacognitive beliefs, and self-reported attention control, but not objective attention control. Treatment gains were maintained at six-month follow-up (d = 1.18). Our results indicate that MCT may be a promising treatment for children and adolescents with anxiety and depression and provide preliminary evidence of changes in CAS, metacognition, and perceived attention control as potential drivers of treatment effects.
初步研究支持元认知疗法(MCT)对患有广泛焦虑症的儿童的可行性,但元认知疗法对治疗患有其他焦虑症和抑郁症的儿童的有效性在很大程度上仍是未知数。本研究的目的是调查元认知疗法针对儿童和青少年焦虑和抑郁症状的相关效果,并研究元认知模型提出的机制。97名年龄在10-17岁之间、患有焦虑症和抑郁症的参与者(中=12.9 ± 1.9,82.5%为女性)接受了八节小组MCT课程。参与者在治疗前和治疗后接受了诊断评估,并在治疗前、治疗中和治疗后完成了症状和过程测量,并在三个月和六个月的随访中再次完成了症状和过程测量。多层次模型用于研究治疗相关效应和中介效应。结果显示,治疗后总症状大幅减少(d = 1.28)。这些症状的减轻与认知注意力综合征(CAS)、元认知信念和自我报告的注意力控制的变化有关,并且在时间上先于这些变化,但与客观注意力控制无关。治疗效果在六个月的随访中得以保持(d = 1.18)。我们的研究结果表明,MCT 对患有焦虑症和抑郁症的儿童和青少年可能是一种很有前景的治疗方法,并提供了初步证据,证明认知注意综合征、元认知和感知注意力控制的变化是治疗效果的潜在驱动因素。
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引用次数: 0
A systematic review and meta-analysis of PTSD symptoms at mid-treatment during trauma-focused treatment for PTSD 创伤后应激障碍集中疗法治疗中期创伤后应激障碍症状的系统回顾和荟萃分析
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-07 DOI: 10.1016/j.janxdis.2024.102925
Lucy Purnell , Alicia Graham , Kenny Chiu , David Trickey , Richard Meiser-Stedman

There is concern that trauma memory processing in psychological therapies leads to PTSD symptom exacerbation. We compared PTSD symptoms at mid-treatment in trauma-focused psychological therapy to control groups. We systematically searched multiple databases and searched grey literature. We included randomised controlled trials involving adults comparing trauma-focused psychological interventions with active non-trauma-focused interventions or waitlist conditions. Twenty-three studies met our inclusion criteria. We found no evidence of PTSD symptom exacerbation at mid-treatment in trauma-focused interventions compared to control groups (g=−.16, [95 % confidence interval, CI, −.34,.03]). Sensitivity analyses with high quality studies (risk of bias assessment ≥ 7; g=−.25; [95 % CI −.48, −.03], k = 12) and studies with passive controls (g=−.32; [95 % CI −.59, −.05], k = 8) yielded small effect sizes favouring trauma-focused interventions. At post-treatment, trauma-focused interventions yielded a medium effect on PTSD symptoms compared to all controls (g=−.57; [CI −.79, −.35], k = 23). Regarding depression, trauma-focused interventions yielded a small effect size compared to controls at mid-treatment (g=−.23; [95 % CI −.39, −.08], k = 12) and post-treatment (g=−.45; [CI −.66, −.25], k = 12). This meta-analysis found no evidence that trauma-focused psychotherapies elicit symptom exacerbation at mid-treatment in terms of PTSD or depression symptoms. Instead, this meta-analysis suggests that the benefits of trauma-focused interventions can be experienced through improved depression and possibly PTSD before the conclusion of therapy. However, it is possible that symptom exacerbation occurred before mid-treatment and/or that people who experience symptom exacerbation drop out of studies and so are not included in the analysis.

有人担心心理疗法中的创伤记忆处理会导致创伤后应激障碍症状加重。我们比较了以创伤为重点的心理治疗组和对照组在治疗中期的创伤后应激障碍症状。我们系统地搜索了多个数据库,并检索了灰色文献。我们纳入了将以创伤为中心的心理干预与积极的非以创伤为中心的干预或等待名单条件进行比较的成人随机对照试验。有 23 项研究符合我们的纳入标准。我们发现,与对照组相比,没有证据表明以创伤为中心的干预措施在治疗中期会导致创伤后应激障碍症状加重(g=-.16,[95% 置信区间,CI, -.34,.03])。通过对高质量研究(偏倚风险评估≥7;g=-.25;[95 % CI -.48,-.03],k = 12)和被动对照研究(g=-.32;[95 % CI -.59,-.05],k = 8)进行敏感性分析,得出了有利于创伤焦点干预的小效应量。在治疗后,与所有对照组相比,以创伤为中心的干预对创伤后应激障碍症状的影响为中等(g=-.57;[CI -.79,-.35],k = 23)。在抑郁方面,在治疗中期(g=-.23;[95 % CI -.39,-.08],k = 12)和治疗后(g=-.45;[CI -.66,-.25],k = 12),与对照组相比,以创伤为中心的干预产生了较小的效应。这项荟萃分析没有发现任何证据表明,就创伤后应激障碍或抑郁症状而言,以创伤为重点的心理疗法在治疗中期会导致症状加重。相反,这项荟萃分析表明,在治疗结束前,以创伤为重点的干预措施可以通过改善抑郁和创伤后应激障碍来带来益处。然而,症状加重有可能发生在治疗中期之前,和/或出现症状加重的人退出了研究,因此未被纳入分析。
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引用次数: 0
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Journal of Anxiety Disorders
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