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Exploring the symptomatology and assessment of emetophobia: A comprehensive scoping review 探讨呕吐恐惧症的症状学和评估:一个全面的范围审查
IF 4.5 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-10-02 DOI: 10.1016/j.janxdis.2025.103076
Molly S. Harbor, Paul E. Jenkins, Kate Harvey
Emetophobia, the specific fear of vomiting, is a poorly understood anxiety disorder. Despite a growing body of research, comprehensive reviews on its presentation and assessment are limited and dated. This scoping review maps, synthesises and explores existing literature on the assessment measures and symptomatology of emetophobia. Its purpose is to inform future clinical practices by identifying reliable assessment instruments and facilitating more accurate diagnosis, treatment planning, and research comparisons. Five online databases (PubMed, SCOPUS, PsycINFO, Google Scholar, PsyArXiy) were searched using terms related to emetophobia. In total, 483 unique articles were located of which 38 were eligible for inclusion (35 described symptomatology; 3 described assessment measures). Among studies exploring symptoms, 17 were single case studies, 11 were cross-sectional surveys and 7 were other designs (e.g., case series, retrospective studies). Findings indicate that emetophobia is a multifaceted condition consisting of physical, psychological and behavioural symptoms. Avoidance behaviours are the most frequently reported symptom, described in 91 % of included literature. There is little research exploring the differences in child and adult symptom presentation which may result in misdiagnosis if an adult-centric criteria is applied. Two self-report questionnaires have been created and their psychometric properties assessed but, given numerous studies relied on longer, unvalidated assessment measures, these two measures appear to need further development. This review establishes that emetophobia is a complex and debilitating condition impacting multiple domains of life. Its findings will inform future research into the development and evaluation of tailored interventions targeting the specific presentation of emetophobia.
呕吐恐惧症是一种对呕吐的特殊恐惧,是一种人们知之甚少的焦虑症。尽管有越来越多的研究,但对其表现和评估的全面审查是有限和过时的。这范围审查地图,综合和探索现有的文献评估措施和吐痰恐惧症的症状。其目的是通过确定可靠的评估工具,促进更准确的诊断、治疗计划和研究比较,为未来的临床实践提供信息。五个在线数据库(PubMed, SCOPUS, PsycINFO,谷歌Scholar, PsyArXiy)使用与呕吐恐惧症相关的术语进行了搜索。总共找到了483篇独特的文章,其中38篇符合纳入条件(35篇描述了症状,3篇描述了评估措施)。在探讨症状的研究中,17项为单一病例研究,11项为横断面调查,7项为其他设计(如病例系列、回顾性研究)。研究结果表明,恐吐症是一种多方面的疾病,包括身体、心理和行为症状。回避行为是最常见的报告症状,在91 %的纳入文献中有描述。很少有研究探讨儿童和成人症状表现的差异,如果采用以成人为中心的标准,可能会导致误诊。已经创建了两份自我报告问卷,并对其心理测量特性进行了评估,但鉴于许多研究依赖于更长时间、未经验证的评估措施,这两项措施似乎需要进一步发展。这篇综述表明,恐吐症是一种复杂的、使人衰弱的疾病,影响着生活的多个领域。它的发现将为未来的研究提供信息,以开发和评估针对恐吐症具体表现的量身定制的干预措施。
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引用次数: 0
Intensive 7-day internet-delivered cognitive behavioural therapy for social anxiety disorder: A randomized controlled trial 强化7天网络认知行为疗法治疗社交焦虑症:一项随机对照试验
IF 4.5 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-10-01 DOI: 10.1016/j.janxdis.2025.103073
Kayla R. Steele , Emily Upton , Monique Holden , Amy Regan , Matthew J. Coleshill , Sophie Li , Amy E. Joubert , Alison E.J. Mahoney , Michael Millard , Jill M. Newby
This is the first randomised controlled trial (RCT) to examine the efficacy of intensive internet-delivered CBT (iCBT) for social anxiety disorder (SAD). Adults (mean age: 44.77 years, 75.4 % female) diagnosed with SAD were randomly allocated to iCBT (n = 33) or a waitlist control group (WLC; n = 28). The iCBT group received a clinician-guided, six lesson program delivered online over seven days. Participants completed self-report measures of social anxiety and depression symptoms, and functional impairment at two- (post-treatment) and six-weeks post-baseline (one-month follow-up), and a diagnostic interview to assess SAD and major depressive disorder (MDD) at baseline and one-month follow-up. The iCBT group reported significantly lower social anxiety symptoms (Hedges’ g’s > .96), and functional impairment at post and one-month follow-up (g’s > .59), but there were no significant differences in depression symptoms (g’s = .42). Participants in the iCBT group were less likely to continue to meet criteria for SAD (47.6 %) at follow-up compared to WLC (96.4 %). Adherence (83.9 % completion) and program satisfaction (85.2 % reported being ‘mostly’ or ‘very satisfied’) were promising. Delivering iCBT over an intensive treatment period is feasible and acceptable to participants with SAD and showed promise for reducing social anxiety and functional impairment. Further research is needed to compare intensive iCBT with active control groups, using a larger and more diverse sample and longer-term outcomes.
这是首个随机对照试验(RCT),旨在检验强化网络CBT (iCBT)治疗社交焦虑症(SAD)的疗效。诊断为SAD的成年人(平均年龄:44.77岁,75.4 %为女性)被随机分配到iCBT组(n = 33)或等候名单对照组(n = 28)。iCBT小组接受了一个临床医生指导的、为期七天的六课在线课程。参与者在治疗后2周和基线后6周(随访1个月)完成了社交焦虑、抑郁症状和功能障碍的自我报告,并在基线和1个月随访时完成了评估SAD和重度抑郁症(MDD)的诊断性访谈。iCBT组报告的社交焦虑症状显著降低(赫奇斯的 >; )。96),工作后和随访1个月的功能障碍(g 's >; )。59),但抑郁症状无显著差异(g 's = .42)。与WLC(96.4 %)相比,iCBT组的参与者在随访时继续满足SAD标准的可能性较小(47.6 %)。依从性(83.9 %完成)和项目满意度(85.2% %报告“大部分”或“非常满意”)很有希望。在强化治疗期间提供iCBT对SAD患者是可行和可接受的,并显示出减少社交焦虑和功能障碍的希望。需要进一步的研究来比较强化iCBT与积极对照组,使用更大、更多样化的样本和更长期的结果。
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引用次数: 0
Physical activity moderates the relationship between PTSD symptom severity and approach-avoidance conflict decision-making 体育活动调节PTSD症状严重程度与方法回避冲突决策之间的关系
IF 4.5 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-26 DOI: 10.1016/j.janxdis.2025.103075
Kevin M. Crombie , Motoki Sato , Samantha A. Chatham , John Leri , Mark T. Richardson , Josh M. Cisler
Avoidance of potentially dangerous contexts is beneficial for survival (i.e., adaptive avoidance), but the generalization of avoidance behavior to other generally safe contexts (i.e., maladaptive avoidance) can lead to detrimental mental health consequences, including diminished potential for reward. Decisions around pursuing reward in the presence of threat or avoiding threat at the cost of obtaining greater reward presents an approach-avoidance conflict (AAC). Although AAC is expected to be biased among trauma-exposed adults, especially those with posttraumatic stress disorder (PTSD), there have only been two prior behavioral investigations of AAC among adults with PTSD or experiencing PTSD symptoms. While greater levels of physical activity (PA) contribute to enhanced cognitive performance during reward-based decision-making tasks, it remains unknown whether greater PA also offers a protective effect or rather dampens the potential for greater AAC and sacrifice of reward in the presence of threat. The current study administered a trauma-related AAC behavioral task to trauma-exposed adults with varying PTSD symptom severity (N = 93), to examine potential interactive relationships between PTSD symptom severity, PA, and AAC decision-making under threat. The task involved a total of 150 trials and was divided into two phases: congruent (the option with the highest probability of a positive point outcome was also the option that was least likely to result in the presentation of a trauma-related image), and conflict (the option with the highest probability of a positive point outcome was also the option that was most likely to result in the presentation of a threat-related image). Results from linear mixed effects models revealed that PA moderated the relationship between PTSD symptom severity and AAC, as we observed a positive relationship between PTSD symptom severity and AAC for lower PA volume (i.e., greater conflict), and a more negative relationship between PTSD symptom severity and AAC as PA volume increased (i.e., less conflict). These results suggest that greater PA may promote a greater propensity to engage in goal-directed behavior and seek reward in the presence of threat in those with greater PTSD symptom severity.
对潜在危险环境的回避有利于生存(即适应性回避),但将回避行为推广到其他一般安全环境(即适应性不良回避)可能导致有害的心理健康后果,包括减少获得奖励的可能性。在存在威胁的情况下追求奖励或以获得更大奖励为代价来避免威胁的决定呈现出一种方法回避冲突(AAC)。尽管AAC在创伤暴露的成年人,特别是创伤后应激障碍(PTSD)患者中存在偏见,但在此之前,只有两项针对创伤后应激障碍或经历创伤后应激障碍症状的成年人的AAC行为调查。虽然在基于奖励的决策任务中,更高水平的身体活动(PA)有助于提高认知表现,但更大的PA是否也提供了保护作用,或者更确切地说,是抑制了在威胁存在时更大的AAC和牺牲奖励的潜力,这一点尚不清楚。本研究对创伤暴露的不同PTSD症状严重程度的成人(N = 93)进行创伤相关的AAC行为任务,以检查PTSD症状严重程度、PA和威胁下AAC决策之间的潜在交互关系。这项任务共涉及150次试验,分为两个阶段:一致性(最有可能得到正面结果的选项也是最不可能导致出现创伤相关图像的选项)和冲突(最有可能得到正面结果的选项也是最有可能导致出现威胁相关图像的选项)。线性混合效应模型的结果显示,PA调节了PTSD症状严重程度与AAC之间的关系,因为我们观察到,当PA容量越小(即冲突越大)时,PTSD症状严重程度与AAC之间呈正相关,而当PA容量越大(即冲突越少)时,PTSD症状严重程度与AAC之间呈负相关。这些结果表明,在PTSD症状严重程度较高的患者中,更大的PA可能会促进更大的倾向于从事目标导向的行为,并在存在威胁的情况下寻求奖励。
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引用次数: 0
Clinician guidance in digital therapeutics for panic disorder: Meta-analytic dissection and implications for regulatory framing and scalable deployment 惊恐障碍数字治疗的临床医生指导:元分析解剖和对监管框架和可扩展部署的影响。
IF 4.5 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-19 DOI: 10.1016/j.janxdis.2025.103074
Inhye Cho , Byung-Hoon Kim , Hankil Lee , Yun-Kyoung Song , Min Jung Chang , Junhyung Kim , Euna Han

Background

Digital therapeutics (DTx) have emerged as scalable and accessible treatment modalities for panic disorder.

Objective

This study aimed to identify the extent to which clinician guidance impacts the digital intervention effectiveness for panic disorder across multiple clinical outcomes.

Methods

This study included 40 randomized controlled trials of digital intervention for panic disorder published up to March 2025. Eligible studies enrolled adults with a primary diagnosis of panic disorder (with or without agoraphobia) and compared a digital therapeutic intervention against active (therapist-led or treatment-as-usual) or passive (waitlist or no-treatment) controls. Outcomes were the Panic Disorder Severity Scale (PDSS), Agoraphobic Cognitions Questionnaire (ACQ), and Body Sensations Questionnaire (BSQ). Random-effects meta-analyses, subgroup analyses, sensitivity analyses, and mixed-effects meta regressions were conducted. The moderator variables included the comparator type, guidance format (clinician-guidance or self-guided), intervention modality, and region.

Results

Self-guided DTx demonstrated a moderate effect size on PDSS (Hedges’ g =0.31, 95 % confidence interval [CI]: 0.05–0.68), whereas clinician-guided interventions exhibited stronger effects (g =0.95, 95 % CI: 0.44–1.46). These findings indicate that well-structured self-guided interventions can address symptom domains, involving panic frequency and physiological distress. Conversely, cognitive-focused outcome assessment using ACQ and BSQ revealed that only clinician-guided interventions yielded statistically significant and clinically meaningful improvements (ACQ: g =0.46, 95 % CI: 0.15–0.76; BSQ: g =0.67, 95 % CI: 0.30–1.05), whereas self-guided formats exhibited negligible effects (ACQ: g =0.11; BSQ: g =0.27).

Conclusions

This meta-analysis revealed that self-guided digital interventions effectively reduce the overall symptom severity in panic disorder, whereas clinician involvement exerts a notably stronger influence on cognition-related outcomes. These findings support a domain-specific and context-sensitive understanding of guidance. Accordingly, the DTx design and policy should match the mechanistic pathways through which psychological change will occur.
背景:数字疗法(DTx)已成为可扩展和可获得的恐慌障碍治疗方式。目的:本研究旨在确定临床医生指导在多大程度上影响了惊恐障碍的多种临床结果的数字化干预效果。方法:本研究纳入截至2025年3月发表的40项数字干预惊恐障碍的随机对照试验。符合条件的研究招募了初步诊断为惊恐障碍(有或没有广场恐怖症)的成年人,并将数字治疗干预与主动(治疗师主导或照常治疗)或被动(等候名单或无治疗)对照进行比较。结果为惊恐障碍严重程度量表(PDSS)、广场恐惧症认知问卷(ACQ)和身体感觉问卷(BSQ)。进行随机效应meta分析、亚组分析、敏感性分析和混合效应meta回归。调节变量包括比较者类型、指导形式(临床指导或自我指导)、干预方式和地区。结果:自我引导的DTx对PDSS表现出中等效应(Hedges' g =0.31, 95 %置信区间[CI]: 0.05-0.68),而临床指导的干预表现出更强的效应(g =0.95, 95 % CI: 0.44-1.46)。这些发现表明,结构良好的自我指导干预可以解决症状领域,包括恐慌频率和生理困扰。相反,使用ACQ和BSQ进行的以认知为中心的结果评估显示,只有临床指导的干预才能产生具有统计学意义和临床意义的改善(ACQ: g =0.46, 95 % CI: 0.15-0.76; BSQ: g =0.67, 95 % CI: 0.30-1.05),而自我指导的干预效果可以忽略(ACQ: g =0.11; BSQ: g =0.27)。结论:本荟萃分析显示,自我指导的数字干预有效地降低了恐慌障碍的整体症状严重程度,而临床医生的参与对认知相关结果的影响明显更强。这些发现支持对指导的特定领域和上下文敏感的理解。因此,DTx的设计和政策应该与心理变化发生的机制途径相匹配。
{"title":"Clinician guidance in digital therapeutics for panic disorder: Meta-analytic dissection and implications for regulatory framing and scalable deployment","authors":"Inhye Cho ,&nbsp;Byung-Hoon Kim ,&nbsp;Hankil Lee ,&nbsp;Yun-Kyoung Song ,&nbsp;Min Jung Chang ,&nbsp;Junhyung Kim ,&nbsp;Euna Han","doi":"10.1016/j.janxdis.2025.103074","DOIUrl":"10.1016/j.janxdis.2025.103074","url":null,"abstract":"<div><h3>Background</h3><div>Digital therapeutics (DTx) have emerged as scalable and accessible treatment modalities for panic disorder.</div></div><div><h3>Objective</h3><div>This study aimed to identify the extent to which clinician guidance impacts the digital intervention effectiveness for panic disorder across multiple clinical outcomes.</div></div><div><h3>Methods</h3><div>This study included 40 randomized controlled trials of digital intervention for panic disorder published up to March 2025. Eligible studies enrolled adults with a primary diagnosis of panic disorder (with or without agoraphobia) and compared a digital therapeutic intervention against active (therapist-led or treatment-as-usual) or passive (waitlist or no-treatment) controls. Outcomes were the Panic Disorder Severity Scale (PDSS), Agoraphobic Cognitions Questionnaire (ACQ), and Body Sensations Questionnaire (BSQ). Random-effects meta-analyses, subgroup analyses, sensitivity analyses, and mixed-effects meta regressions were conducted. The moderator variables included the comparator type, guidance format (clinician-guidance or self-guided), intervention modality, and region.</div></div><div><h3>Results</h3><div>Self-guided DTx demonstrated a moderate effect size on PDSS (Hedges’ g =0.31, 95 % confidence interval [CI]: 0.05–0.68), whereas clinician-guided interventions exhibited stronger effects (g =0.95, 95 % CI: 0.44–1.46). These findings indicate that well-structured self-guided interventions can address symptom domains, involving panic frequency and physiological distress. Conversely, cognitive-focused outcome assessment using ACQ and BSQ revealed that only clinician-guided interventions yielded statistically significant and clinically meaningful improvements (ACQ: g =0.46, 95 % CI: 0.15–0.76; BSQ: g =0.67, 95 % CI: 0.30–1.05), whereas self-guided formats exhibited negligible effects (ACQ: g =0.11; BSQ: g =0.27).</div></div><div><h3>Conclusions</h3><div>This meta-analysis revealed that self-guided digital interventions effectively reduce the overall symptom severity in panic disorder, whereas clinician involvement exerts a notably stronger influence on cognition-related outcomes. These findings support a domain-specific and context-sensitive understanding of guidance. Accordingly, the DTx design and policy should match the mechanistic pathways through which psychological change will occur.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"115 ","pages":"Article 103074"},"PeriodicalIF":4.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Efficacy of imagery rescripting in treating mental disorders associated with aversive memories – An updated meta-analysis” [Journal of Anxiety Disorders 99 (2023) 102772] “意象重写在治疗与厌恶记忆相关的精神障碍中的功效——一项更新的荟萃分析”的更正[焦虑障碍杂志99(2023)102772]。
IF 4.5 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-19 DOI: 10.1016/j.janxdis.2025.103071
Ahlke Kip , Luisa Schoppe , Arnoud Arntz , Nexhmedin Morina
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引用次数: 0
The screen for child anxiety related emotional disorders scale: A longitudinal validation study based on Chinese children and adolescents 儿童焦虑相关情绪障碍量表的筛选:基于中国儿童和青少年的纵向验证研究
IF 4.5 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-18 DOI: 10.1016/j.janxdis.2025.103072
Xiang Li, Daniel T.L. Shek, Xintong Zhang
As anxiety disorders are common and clinically significant psychiatric disorders in children and adolescents linked to a broad spectrum of psychiatric problems, we need valid assessment instruments of anxiety. The Screen for Child Anxiety Related Emotional Disorders (SCARED) is widely used to assess anxiety symptoms. However, its factor structure remains debated, and its psychometric properties are underexplored in China. This study examined the factor structure of the SCARED and its measurement invariance across gender, age, and time among Chinese students. Specifically, this study used a two-wave longitudinal design, with a six-month interval (Time 1: December 2019–January 2020; Time 2: June 2020–July 2020). Data included 6176 children and adolescents aged 8–19 years (51.6 % boys; mean age = 11.52, SD = 1.62) from Sichuan, China. Confirmatory factor analyses supported a five-factor model as the best fit. Measurement invariances across gender, age, and time were established at the configural, metric, scalar, error variance, factor variance, and factor covariance levels, as supported by changes in the comparative fit index (CFI ≤ 0.004) and root mean square error of approximation (RMSEA ≤ 0.002). Furthermore, structured means modeling analyses showed that girls experienced more anxiety than did boys. Children experienced higher separation anxiety but lower general anxiety and school phobia than did adolescents. Moreover, participants experienced fewer anxiety symptoms at Time 2. Overall, the SCARED was valid and reliable for measuring anxiety symptoms in Chinese children and adolescents, confirming its utility as an objective outcome measure.
由于焦虑症在儿童和青少年中是一种常见且临床意义重大的精神疾病,与广泛的精神问题有关,我们需要有效的焦虑评估工具。儿童焦虑相关情绪障碍筛查(fear)被广泛用于评估焦虑症状。然而,其因素结构仍存在争议,其心理测量学特征在中国尚未得到充分探索。本研究考察了中国学生恐惧心理的因素结构及其在性别、年龄和时间上的测量不变性。具体来说,本研究采用了两波纵向设计,间隔6个月(时间1:2019年12月- 2020年1月;时间2:2020年6月- 2020年7月)。数据包括来自中国四川的6176名8-19岁的儿童和青少年(51.6 %男孩,平均年龄= 11.52,SD = 1.62)。验证性因子分析支持五因子模型为最佳拟合。通过比较拟合指数(CFI≤0.004)和近似均方根误差(RMSEA≤0.002)的变化,在构型、度量、标量、误差方差、因子方差和因子协方差水平上建立跨性别、年龄和时间的测量不变性。此外,结构化均值模型分析显示,女孩比男孩更焦虑。与青少年相比,儿童经历了更高的分离焦虑,但总体焦虑和学校恐惧症较低。此外,参与者在时间2时的焦虑症状较少。总的来说,在测量中国儿童和青少年的焦虑症状时,scare是有效和可靠的,证实了它作为一种客观结果测量的效用。
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引用次数: 0
Assessing reliable change, MCID, treatment response, and remission using the Pediatric Anxiety Rating Scale (PARS) in youth with anxiety disorders 使用儿童焦虑评定量表(PARS)评估青少年焦虑症的可靠变化、MCID、治疗反应和缓解
IF 4.5 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-11 DOI: 10.1016/j.janxdis.2025.103070
Matti Cervin , Philip C. Kendall , John C. Piacentini , Elizabeth A. Gosch , Jeffrey J. Wood , Sophie C. Schneider , Alison Salloum , Boris Birmaher , Andrew G. Guzick , David Mataix-Cols , Eric A. Storch
Youth anxiety disorders are common and heterogeneous. The Pediatric Anxiety Rating Scale (PARS) is a clinician-administered tool designed to assess overall anxiety severity, independent of specific symptoms. The thresholds on PARS for the reliable change index (RCI), the minimal clinically important difference (MCID), treatment response, and full and partial remission remain unclear. Using the Clinical Global Impression (CGI) scales and diagnostic interviews as benchmark measures, several thresholds for the 6-item PARS were estimated using data from 904 youth with anxiety disorders, of which 36 % had an autism diagnosis. Data were drawn from 9 clinical trials conducted in the United States. Threshold accuracy was evaluated in a holdout sample and in an independent Swedish sample (n = 49). The reliable change index (RCI) was 3.39 points. A raw score reduction of ≥ 4 points or a ≥ 20 % reduction best defined the MCID. A raw score reduction of ≥ 8 points or a ≥ 43 % reduction best defined treatment response. Scores of 0–10 after treatment accurately defined full and partial remission, and scores of 0–5 defined full remission. Threshold accuracies ranged from 74–91 % in the holdout and 67–78 % in the Swedish sample. Treatment response accuracy was similar across samples, while MCID accuracy was lower in the Swedish sample. Similar cutoffs emerged in youth with and without autism and across age groups and genders. Threshold accuracies for the 5- and 7-item PARS versions were comparable to the 6-item version. This study establishes response and remission thresholds for PARS that are applicable across age groups, genders, and autism status. We advise against using the RCI as it does not exceed the MCID.
青少年焦虑症是常见的,也是异质性的。儿童焦虑评定量表(PARS)是一种临床医生管理的工具,旨在评估整体焦虑严重程度,独立于特定症状。PARS的可靠变化指数(RCI)、最小临床重要差异(MCID)、治疗反应以及完全和部分缓解的阈值仍不清楚。使用临床总体印象(CGI)量表和诊断访谈作为基准测量,使用904名患有焦虑症的青少年的数据估计了6项PARS的几个阈值,其中36% %被诊断为自闭症。数据来自于在美国进行的9项临床试验。阈值准确性在一个不含样本和一个独立的瑞典样本中进行评估(n = 49)。可靠变化指数(RCI)为3.39点。原始评分降低≥ 4分或≥ 20 %是MCID的最佳定义。原始评分降低≥ 8分或降低≥ 43 %为最佳治疗反应定义。治疗后0-10分准确定义完全缓解和部分缓解,0-5分定义完全缓解。阈值准确度范围从74-91 %在坚持和67-78 %在瑞典样本。不同样本的治疗反应准确性相似,而瑞典样本的MCID准确性较低。在有自闭症和没有自闭症的年轻人中,以及在不同年龄组和性别中,也出现了类似的截止点。5项和7项PARS版本的阈值准确性与6项版本相当。本研究建立了适用于不同年龄组、性别和自闭症状态的PARS的反应和缓解阈值。我们不建议使用RCI,因为它不超过MCID。
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引用次数: 0
Brain-heart coupling in response to imminent threat in panic disorder, social anxiety disorder, and healthy controls 惊恐障碍、社交焦虑障碍和健康对照对迫在眉睫威胁的脑-心耦合反应
IF 4.5 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-06 DOI: 10.1016/j.janxdis.2025.103069
Sarah-Louise Unterschemmann , Christian Panitz , Pauline Petereit , Hannah Comtesse , Matthias F.J. Sperl , Erik M. Mueller

Background

Imminent threat does not only capture attention but also triggers defensive psychophysiological responses associated with fight-flight-freeze behavior. However, within-subject associations between central markers of attentional stimulus processing and peripheral components of early defensive activation (e.g., cardiac acceleration) are not well understood. These associations may be especially important in understanding dynamics of anxiety disorders that are characterized by cardiovascular symptoms such as panic disorder.

Methods

We analyzed data from N = 90 participants with panic disorder (PD), social anxiety disorder (SAD), as well as healthy controls (CG) who completed a threat conditioning paradigm with face stimuli as conditioned stimuli (CS) and an aversive white noise burst as unconditioned stimulus (US). In addition to univariate analyses of ERPs and heartbeat, single-trial EEG evoked by the noise burst at centromedial sites and heart period were used to calculate intraindividual coupling of unconditioned cortico-cardiac responses.

Results

The noise burst evoked strong cardiac acceleration and an event-related potential with a pronounced N100 component. Importantly, the magnitude of single-trial cardiac acceleration was predicted within individuals by the preceding single-trial N100 magnitude. This cortico-cardiac coupling, but not the N100 component or cardiac acceleration per se, was enhanced in individuals with panic disorder compared to social anxiety disorder, with intermediate levels of coupling observed in healthy controls.

Conclusion

The present results suggest a central role of early attentional stimulus processing in subsequent cardiac defensive responses. Furthermore, they indicate that cortico-cardiac defensive responses may be altered in individuals with panic disorder specifically, rather than in anxiety disorders in general.
迫在眉睫的威胁不仅会吸引注意力,还会引发与战斗-逃跑-冻结行为相关的防御性心理生理反应。然而,注意刺激处理的中心标记与早期防御激活的外围成分(如心脏加速)之间的主体内关联尚未得到很好的理解。这些关联对于理解以恐慌症等心血管症状为特征的焦虑障碍的动力学尤为重要。方法对惊恐障碍(PD)、社交焦虑障碍(SAD)和健康对照组(CG)的90名参与者(N = )进行数据分析,这些参与者完成了以面部刺激为条件刺激(CS)和以厌恶白噪声爆发为非条件刺激(US)的威胁条件反射范式。除了erp和心跳的单变量分析外,我们还使用中央中心位置和心脏周期的噪声爆发引起的单试验脑电图来计算非条件皮质-心脏反应的个体内耦合。结果噪声诱发了强烈的心脏加速和具有明显N100成分的事件相关电位。重要的是,单次试验心脏加速的幅度是通过之前的单次试验N100幅度来预测的。与社交焦虑障碍患者相比,惊恐障碍患者的这种皮质-心脏耦合(而非N100成分或心脏加速本身)增强,在健康对照中观察到中等水平的耦合。结论早期注意刺激加工在随后的心脏防御反应中起核心作用。此外,他们指出,皮质-心脏防御反应可能在惊恐障碍患者中发生改变,而不是在一般的焦虑症中发生改变。
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引用次数: 0
Safety behavior fading for social anxiety: A randomized controlled trial of a self-monitoring intervention 社交焦虑的安全行为消退:自我监控干预的随机对照试验
IF 4.5 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-31 DOI: 10.1016/j.janxdis.2025.103068
James M. Zech , Tapan A. Patel , Jesse R. Cougle
Safety behaviors (SBs) are hypothesized to play a key role in social anxiety and present as a viable target of psychosocial treatments. While SB reduction is a component of some cognitive-behavioral therapies for social anxiety, prior research suggests safety behavior fading also represents a viable, standalone digital treatment for social anxiety. The aim of the present study was to test a one-month self-monitoring SB treatment in individuals reporting elevated social anxiety symptoms against a credible control condition. Participants (N = 201) were randomized to either a SB fading condition (n = 99) or an unhealthy behavior fading control (n = 102). Compared to control, SB fading led to lower SB use at post but not one-month follow-up. Contrary to predictions, both conditions saw significant and comparable reductions in social anxiety and related outcomes (depression, loneliness) at posttreatment and follow-up. Treatment credibility and expectancy moderated the effect of condition, such that among participants with more positive beliefs about treatment (after being provided with the rationale), those in the SB condition reported significantly lower follow-up social anxiety than those in control. Further, in the SB condition, both higher social interaction frequency and lower loneliness at baseline were predictive of lower social anxiety at follow-up. Overall, our findings show limitations to SB fading as a standalone intervention and suggest this strategy is more effective among those who interact with others more frequently and who are more confident in this treatment approach. We discuss clinical implications and future research directions, including potential refinements to SB treatment protocols.
安全行为(SBs)被假设在社交焦虑中发挥关键作用,并作为社会心理治疗的可行目标。虽然减少SB是社交焦虑的一些认知行为疗法的一个组成部分,但之前的研究表明,安全行为消退也代表了一种可行的、独立的社交焦虑数字治疗方法。本研究的目的是在可信的对照条件下,对报告社交焦虑症状升高的个体进行为期一个月的自我监测SB治疗。参与者(N = 201)被随机分为两组,一组是SB消退组(N = 99),另一组是不健康行为消退组(N = 102)。与对照组相比,脑缺血消退导致术后脑缺血使用减少,但1个月随访时无此影响。与预测相反,在治疗后和随访中,两种情况下的社交焦虑和相关结果(抑郁、孤独)都有显著和可比的减少。治疗可信度和期望调节了条件的影响,因此在对治疗有更积极信念的参与者中(在提供基本原理后),SB条件下的参与者报告的随访社交焦虑显著低于对照组。此外,在SB条件下,基线时较高的社交互动频率和较低的孤独感预示着随访时较低的社交焦虑。总的来说,我们的研究结果表明SB消退作为单独干预的局限性,并表明这种策略对那些与他人互动更频繁和对这种治疗方法更有信心的人更有效。我们讨论了临床意义和未来的研究方向,包括对SB治疗方案的潜在改进。
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引用次数: 0
Predicting anxiety symptoms through gaze-directed attention: A mobile eye-tracking study of adolescents during a real-world speech task 通过注视引导注意力预测焦虑症状:在现实世界的言语任务中对青少年的移动眼动追踪研究
IF 4.5 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-14 DOI: 10.1016/j.janxdis.2025.103058
Emily Hutchinson , Erica Huynh , Mary Woody , Dev Chopra , Amelia Lint , Enoch Du , Kristy Benoit Allen , Cecile Ladouceur , Jennifer Silk
Adolescence is a key period in which anxiety symptoms dramatically increase, particularly among adolescent girls. Identifying potentially-modifiable risk factors that contribute to anxiety symptoms may be critical to mitigate anxiety symptoms and disorders among youth. Attention biases are one set of cognitive risk factors implicated in the development and maintenance of anxiety disorders. Yet previous research remains mixed as to what pattern of attention bias characterizes adolescents at-risk for developing anxiety. Further, prior literature has largely relied on indirect measures of attention (e.g., reaction time) and tasks with low ecological validity. The present study investigated how attention to social evaluative feedback contributed to concurrent and prospective anxiety symptoms in adolescent girls (n = 90, baseline Mage = 12.31, SD =.83). The present study used a novel speech task and mobile eye-tracking technology to assess gaze-directed attention in an ecologically valid context that adolescents encounter daily. We hypothesized that adolescents who engage in vigilance, avoidance, and the combination of vigilance-avoidance of potentially critical social evaluative feedback would report greater concurrent and prospective anxiety symptoms. We also explored the association between gaze-directed attention to positive social feedback. Contrary to our hypotheses, adolescents who exhibited both initial and sustained avoidance of potentially critical social feedback reported the greatest anxiety three-years later, controlling for baseline anxiety symptoms. Findings highlight the importance of avoidance in real-world socially threatening scenarios in contributing to and maintaining anxiety. Findings also highlight the value of studying attention biases that contribute to anxiety symptoms among adolescents using reliable methods and in real-world contexts.
青春期是焦虑症状急剧增加的关键时期,特别是在青春期女孩中。确定导致焦虑症状的潜在可改变的风险因素可能对减轻青少年的焦虑症状和障碍至关重要。注意偏差是一组涉及发展和维持焦虑症的认知风险因素。然而,之前的研究仍然是混合的,关于什么样的注意力偏差模式是青少年发展焦虑风险的特征。此外,先前的文献在很大程度上依赖于注意力的间接测量(如反应时间)和低生态效度的任务。本研究调查了对社会评价反馈的关注对青春期女孩并发和预期焦虑症状的影响(n = 90,基线Mage = 12.31, SD = 0.83)。本研究使用一种新颖的语音任务和移动眼动追踪技术来评估青少年在生态有效的环境中每天遇到的凝视注意力。我们假设,对潜在的批判性社会评价反馈保持警惕、回避以及警惕-回避结合的青少年会报告更大的并发和预期焦虑症状。我们还探讨了注视导向注意力与积极社会反馈之间的关系。与我们的假设相反,在控制基线焦虑症状的情况下,表现出最初和持续回避潜在批评性社会反馈的青少年在三年后报告了最大的焦虑。研究结果强调了在现实世界的社会威胁情境中,回避在促进和维持焦虑方面的重要性。研究结果还强调了使用可靠的方法和在现实环境中研究导致青少年焦虑症状的注意力偏差的价值。
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Journal of Anxiety Disorders
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