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Febril Nöbet Tanılı Hastaların Demografik Ve Klinik Özellikleri 热性惊厥患者的人口统计学和临床特征
Pub Date : 2024-08-09 DOI: 10.55517/mrr.1517769
Saber Ali Ahmed, Nesrin Ceylan
Amaç: Çocukluk çağında en sık görülen yaş ile ilişkili, selim ve ateşle ortaya çıkan nöbetler febril nöbetlerdir. Süt çocuğu ve erken çocukluk döneminde (altı ay- beş yaş arası çocuklarda), santral sinir sisteminde herhangi bir hastalık ve elektrolit düzensizliği olmaksızın, ateşin eşlik ettiği nöbet tipi “febril nöbet” olarak tanımlanmaktadır (Shinnar vd., 2002). Nöbet eşiğinin düşük olduğu, enfeksiyonlara eğilimin daha sık ve ateş yanıtının daha yoğun olduğu erken çocukluk döneminde daha sık görülmektedir. Genellikle ateşle seyreden bir enfeksiyon hastalığının ilk günü içerisinde karşımıza çıkar. En sık olarak viral enfeksiyonlarla birlikte meydana geldiği bilinmektedir. Human herpes simpleks virus 6 enfeksiyonları ve Shigella gastroenteriti ile birlikte daha sık görüldüğü belirlenmiştir (Mewasingh, 2014). Basit ve komplike tip olmak üzere iki sınıfa ayırmak mümkündür. Basit tip; jeneralize nöbet şeklinde ve ateş 38°C’nin üzerinde iken meydana gelir, 15 dakikadan kısa sürer, 24 saat içinde tekrarlama göstermez ve ailede ateşli nöbet öyküsü olabilmektedir. Komplike tipte ise nöbetler fokal tarzda, 15 dakikadan uzun ve 24 saatte birden fazla tekrarlayabilen özelliktedir (Whelan vd., 2017). Febril nöbetle başvuran hastaların klinik özellikleri (süresi, tipi) ve neden olan enfeksiyon etkenlerinin tetkik edilmesi, ailenin bu konuda bilgilendirilmesi ve hastaların takibi için farklı bölgelerde farklı demografik yapıya sahip topluluklarla yapılan çalışmalara ihtiyaç vardır. Bu çalışmada çocukluk çağında febril nöbetlerin tanısı ve takibinde önemli olan öykü ve fizik muayene özelliklerinin araştırılması planlanmıştır. Bu çalışmada sonuçlar multidisipliner ekip anlayışı ile değerlendirilerek erken tanı-önleme-müdahale programları geliştirilmesine ve literatüre katkı sağlamak amaçlanmıştır. Gereç ve Yöntem: Çalışma T.C. Sağlık Bilimleri Üniversitesi Ankara Bilkent Şehir Hastanesi Çocuk Nöroloji Kliniğinde planlanmıştır. Çalışmamız retrospektif nitelikte bir çalışma olup; Aralık 2019-Aralık 2021 tarihleri arasında başvuran ve febril nöbet öyküsü olan tüm hastalar çalışmamıza dahil edilmiştir. Mevcut çalışma için gerekli veriler; Ankara Bilkent Şehir Hastanesi Çocuk Sağlığı ve Hastalıkları hastanesinde kullanılan veri tabanından sistematik olarak elde edildikten sonra her hasta için elde edilen veriler, hasta veri izlem formuna kaydedilmiştir. Araştırma verilerinin istatistiksel analizleri için IBM Statistical Package for Social Sciences (SPSS), Windows için sürüm 26.0 (SPSS Inc. Chicago, USA) bilgisayar paket programı kullanılmıştır. Bulgular: Çalışmaya toplam 165 hasta dâhil edilmiştir. Hastaların yaş ortalaması 25,5±14,7 ay, ortancası 22,0 (3,0-87,0) aydır. Hastaların %10,9’u 3 nöbet görülmüştür. Gruplar arasında anlamlı fark saptanmıştır (p
目的:发热性惊厥是儿童时期与年龄相关的最常见的良性惊厥,与发热同时发生。在婴幼儿时期(6 个月至 5 岁的儿童),中枢神经系统中伴有发热但无任何疾病和电解质紊乱的发作类型被定义为 "发热性惊厥"(Shinnar 等人,2002 年)。发热性惊厥多见于幼儿期,此时惊厥阈值较低、感染倾向较频繁、发热反应较强烈。它通常发生在感染性疾病并伴有发烧的第一天。据了解,病毒感染时最常出现这种情况。据测定,人类单纯疱疹病毒 6 感染和志贺氏杆菌肠胃炎更常出现这种情况(Mewasingh,2014 年)。它可分为简单型和复杂型两类。单纯型以全身抽搐的形式出现,发热超过 38°C,持续时间少于 15 分钟,24 小时内不复发,可能有发热性抽搐的家族史。在复杂类型中,癫痫发作是局灶性的,持续时间超过 15 分钟,并可能在 24 小时内复发一次以上(Whelan 等人,2017 年)。有必要对不同地区不同人口结构的人群进行研究,以调查发热性癫痫发作患者的临床特征(持续时间、类型)和致病传染源,告知家属这一问题,并对患者进行随访。本研究计划调查病史和体格检查的特点,这对诊断和随访儿童发热性惊厥非常重要。本研究旨在为文献做出贡献,并通过评估多学科团队方法的结果来制定早期诊断-预防-干预方案。材料和方法:研究计划在土耳其安卡拉卫生科学大学安卡拉比尔肯特市医院小儿神经病学诊所进行。我们的研究是一项回顾性研究;在 2019 年 12 月至 2021 年 12 月期间入院的所有有发热性癫痫发作病史的患者均被纳入我们的研究。本次研究所需的数据均从安卡拉比尔肯特市医院儿科医院使用的数据库中系统获取,每位患者的数据均记录在患者数据跟踪表中。数据统计分析采用 IBM 26.0 Windows 版社会科学统计软件包(SPSS)(美国芝加哥 SPSS 公司)。结果本研究共纳入 165 名患者。患者的平均年龄为(25.5±14.7)个月,中位数为 22.0(3.0-87.0)个月。10.9%的患者有 3 次癫痫发作。两组之间存在明显差异(P
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引用次数: 0
Unraveling the Enigma: Omental Torsion in a Patient with Non-specific Abdominal Pain 揭开谜底非特异性腹痛患者的网膜扭转
Pub Date : 2024-01-30 DOI: 10.55517/mrr.1413512
Serhat Binici, Emre Teke
Omental torsion is a rare cause of acute abdominal pain, with an incidence rate of less than 0.37%. Due to its non-specific symptoms, it is often confused with other causes of acute abdominal pain, such as acute appendicitis. In this case presentation, we will discuss a 26-year-old male patient who presented to the emergency department with complaints of abdominal pain and was diagnosed with perioperative omental torsion. The diagnosis of omental torsion is challenging due to its non-specific symptoms. When a diagnosis cannot be established in acute pain, diagnostic laparoscopy should not be delayed. Omental torsion can be easily treated with laparoscopic omentectomy.
网膜扭转是一种罕见的急性腹痛病因,发病率低于 0.37%。由于其症状无特异性,常常与急性阑尾炎等其他原因引起的急性腹痛相混淆。在本病例中,我们将讨论一名 26 岁的男性患者,他以腹痛为主诉到急诊科就诊,被诊断为围术期网膜扭转。由于网膜扭转的症状不具特异性,其诊断具有挑战性。当急性疼痛无法确诊时,腹腔镜诊断不容拖延。腹腔镜网膜切除术可轻松治疗网膜扭转。
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引用次数: 0
A Rare Case of Acute Respiratory Distress Due to Hydrochloric Acid Inhalation 吸入盐酸导致急性呼吸窘迫的罕见病例
Pub Date : 2024-01-08 DOI: 10.55517/mrr.1373202
Saim Türkoğlu, Nuruban Delal Baykal, Ali Mahir Gündüz, Cemil Goya, Esra Gürbüz
Although lung injury due to inhalation of Hydrochloric acid (HCl) occurs frequently, imaging findings are not well known. In this case, we aimed to discuss the progression of the patient who developed ARDS (Acute Respiratory Distress Syndrome) after inhalation of hydrochloric acid and progressive during follow-up. A 37-year-old female patient who was followed for asthma was admitted to the outpatient clinic with complaints of sudden dyspnea and chest pain after cleaning with bleach at home. In both lungs, patchy glassy opacities and consolidations were observed, progressively progressing towards the periphery. The patient was clinically diagnosed as acute respiratory distress syndrome. Hydrochloric acid was detected as the etiological agent. Hydrochloric acid is a colorless, which is used as a powerful cleaning agent in everyday use. Radiologists should be aware of the radiographic findings of pulmonary intoxication. Some of these may be life-threatening and require urgent diagnosis. When the general condition of the patient is bad and the anamnesis cannot be obtained by clinicians, radiological findings can be recognized, and guidance tips can be given to the clinician. In this way, they should aim to reduce the mortality and morbidity by recognizing the fatal diseases such as ARDS which may develop in patients as a result of intoxication and with early treatment.
虽然吸入盐酸(HCl)导致的肺损伤经常发生,但成像结果却鲜为人知。在本病例中,我们旨在讨论吸入盐酸后出现 ARDS(急性呼吸窘迫综合征)的患者的病情进展以及随访期间的进展情况。一名因哮喘接受随访的 37 岁女性患者在家中使用漂白剂清洁后,因主诉突然出现呼吸困难和胸痛而被送入门诊。患者的双肺出现斑片状玻璃样不张和合并症,并逐渐向周围发展。患者被临床诊断为急性呼吸窘迫综合征。经检测,病原体为盐酸。盐酸是一种无色液体,在日常生活中被用作强力清洁剂。放射科医生应了解肺中毒的放射学检查结果。其中有些可能危及生命,需要紧急诊断。当患者全身状况不佳而临床医生又无法获得其病史时,可通过放射学检查结果进行识别,并向临床医生提供指导性提示。这样,他们就能识别病人因中毒而可能出现的致命疾病,如 ARDS,并及早治疗,从而降低死亡率和发病率。
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引用次数: 0
Assessing Sarcopenic Obesity Risk in Children During the COVID-19 Pandemic: Grip-to-BMI Ratio 评估 COVID-19 大流行期间儿童患肌肉松弛性肥胖症的风险:握力与体重指数之比
Pub Date : 2023-12-05 DOI: 10.55517/mrr.1374119
Bahar Öztelcan Gündüz, Aysu Duyan Çamurdan, Mücahit Yildiz, F. N. Baran Aksakal, Emine Nüket Ünsal
Objective: The present investigation aimed to examine the prevalence of sarcopenic obesity in Turkish children aged 6-10 years during the COVID-19 pandemic, while also conducting a comparison of diagnostic methods. Methods: A total of 431 healthy children (230 females, 201 males) were recruited for this study. Various anthropometric measurements, including height, weight, and body mass index (BMI), were collected. Furthermore, body composition was assessed through the utilization of bioelectrical impedance analysis (BIA) to ascertain fat mass, skeletal muscle mass, and the muscle-to-fat ratio (MFR). Additionally, grip strength was measured to determine the grip strength-to-BMI ratio. McCarthy's framework was employed to define sarcopenic obesity based on MFR cut-offs. Receiver operating characteristic curves were implemented to evaluate the efficacy of the grip strength-to-BMI ratio in identifying the risk of sarcopenic obesity. Results: The prevalence of sarcopenic obesity was found to be 7.8% in females and 8.4% in males. In comparison to the MFR, the grip strength-to-BMI ratio exhibited considerable sensitivity in detecting the risk of sarcopenic obesity. The correlation between the ratio of grip strength to BMI and the muscle-to-fat ratio (MFR) was found to be weak among boys and girls aged 6-8 years (r=0.363, r=0.458, p
目的:本研究旨在调查2019冠状病毒病大流行期间土耳其6-10岁儿童肌肉减少性肥胖的患病率,同时对诊断方法进行比较。方法:共招募健康儿童431例,其中女性230例,男性201例。收集了各种人体测量数据,包括身高、体重和身体质量指数(BMI)。此外,通过利用生物电阻抗分析(BIA)来评估身体成分,以确定脂肪量、骨骼肌量和肌肉脂肪比(MFR)。此外,测量握力以确定握力与bmi的比值。麦卡锡的框架被用来定义基于MFR截断的肌肉减少型肥胖。采用受试者工作特征曲线来评估握力与bmi比值在识别肌肉减少型肥胖风险方面的有效性。结果:骨骼肌减少性肥胖女性患病率为7.8%,男性患病率为8.4%。与MFR相比,握力- bmi比值在检测肌少性肥胖风险方面表现出相当高的敏感性。在6-8岁的男孩和女孩中,握力与体重指数之比与肌脂比(MFR)之间的相关性较弱(r=0.363, r=0.458, p
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引用次数: 0
Conservative Management of Large Vertex Extradural Hematoma: A Case Report 大顶点硬膜外血肿的保守治疗1例
Pub Date : 2023-09-22 DOI: 10.55517/mrr.1330628
Bekir TUNÇ, Emin ÇAĞIL, Goksal GUNERHAN, Egemen IŞITAN
Vertex extradural hematomas may be missed when axial section brain computed tomographic scans are used alone for diagnosis. Conservative treatment may be preferred in such patients when actualized the essential conditions. A 24-year-old mentally retarded male patient was admitted to the emergency department with a history of falling from the same level and head trauma. Neurological examination and axial cross-sectional brain computed tomography performed in the emergency room were evaluated as normal, and the patient was discharged. Vertex extradural hematoma adjacent to the bone fracture was diagnosed with axial, coronal and sagittal reconstructed brain computerized tomography sections of the patient who came back with headache complaint 2 days later. Despite the difficulties in neurological examination due to mental retardation, surgical treatment was not planned with very close neurological examination. The patient was followed up in the neurosurgery intensive care unit for 2 days and in the neurosurgery service for 7 days. He was discharged because there was no abnormality in his neurological follow-ups and no increase in hematoma size. In the first outpatient follow-up, one month later, the hematoma was completely resorbed. The patient was treated conservatively with close conscious and neurological examination follow-up. In order not to miss vertex extradural hematomas in the brain computed tomography performed in patients presenting to the emergency department with head trauma, coronal and sagittal sections should be reconstructed in addition to axial sections. Conservative treatment can be preferred if vertex extradural hematomas are neurological examined closely, no motor deficits and there is no increase in hematoma size in control imaging.
当单纯使用脑轴位断层扫描诊断时,可能会遗漏顶点硬膜外血肿。当基本条件满足时,保守治疗可能是首选。一名24岁的智障男性患者,曾从同一高度坠落,头部外伤。在急诊室进行的神经学检查和轴向横断脑计算机断层扫描评估正常,患者出院。患者于2天后以头痛主诉复诊,经轴位、冠状位和矢状位重建脑ct片诊断为骨折旁的硬膜外顶点血肿。由于精神发育迟滞,神经系统检查困难,但由于神经系统检查非常密切,没有计划手术治疗。患者在神经外科重症监护病房随访2天,神经外科随访7天。他出院了,因为他的神经随访没有异常,血肿大小没有增加。在第一次门诊随访中,一个月后,血肿完全被吸收。患者保守治疗,严密的意识和神经学检查随访。在急诊就诊的头部外伤患者,为了不遗漏脑膜外顶点血肿,除了轴向切片外,还应重建冠状面和矢状面切片。如果脑脊膜外顶点血肿经过严密的神经学检查,没有运动障碍,对照影像学检查血肿大小没有增加,则可优先采用保守治疗。
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引用次数: 0
Son 10 Yılda Hemşirelik Alanında Semptom Yönetimi Konulu Yüksek Lisans ve Doktora Tezlerin Retrospektif İncelenmesi 对过去 10 年有关护理学症状管理的硕士和博士论文进行回顾性研究
Pub Date : 2023-09-18 DOI: 10.55517/mrr.1182383
Rabia TANRIKUT, Aysegul KOC
Amaç: Semptom, bireylerin subjektif olarak deneyimlediği ve kendisinde bire bir fark ettiği, gözlemlediği belirtilerin tamamı olarak tanımlanmaktadır. Semptom yönetimi ise bireyin hayatını ciddi derecede etkileyen, hastalık durumunda yaşam kalitesini yükseltmek için uygulanan bakımın tamamıdır. Bununla birlikte, semptom yönetimi kişilerde doğru şekilde yürütülür ise bireyin yaşamdan doyumunda artışta, hastaneye tekrarlı yatışları ve semptom yükünü azaltmada etkili olduğu saptanmıştır. Etkili semptom yönetimi için profesyonel meslek grubu olan hemşirelerin bilgi ve beceri düzeyleri yeterli olmalıdır. Yöntem: Retrospektif tanımlayıcı tipteki bu çalışmada, semptom yönetimi konulu çalışmaları belirlemek amacı ile Yükseköğretim Kurulu Ulusal Tez Merkezinde bulunan konuyla ilgili lisansüstü (yüksek lisans-doktora) tezleri incelenmiştir. Bulgular: “Semptom”, “Semptom yönetimi” ve “Hemşirelik” anahtar kelimesi ile tarama yapılmıştır. Yapılan inceleme sonucunda 7 yüksek lisans ve 16 doktora, toplamda 23 teze ulaşılmıştır. Tezlerin % 65,19’ unun (n= 15) son 5 yılda yapıldığı, çalışma desenlerine göre incelendiğinde %39.19’unun’inin (n=9) randomize çalışma desenine sahip olduğu, örneklem grubu incelendiğinde %91.30’unun (n=21) hastaların oluşturduğu ve çalışmalar değerlendirildiğinde % 47.82 ‘sinin (n=11) kanıt 2 düzeyde olduğu görülmüştür. Sonuç: Son yıllarda yapılmış olan tezlerde bireylerin ve hemşirelerin semptom yönetimi bilgi düzeyleri ile ilgili çok fazla çalışma yapıldığı görülmüştür. Yapılan tezlerde randomize kontrollü çalışmaların fazla olmasından dolayı tanımlayıcı çalışmalar yapılması önerilir.
客观:症状是指个人主观感受到的、自己认识和观察到的所有症状。症状管理是在疾病严重影响个人生活的情况下,为改善生活质量而采取的整体护理措施。然而,如果能正确地对患者进行症状管理,就能有效提高患者对生活的满意度,减少反复住院和症状负担。要有效地进行症状管理,作为专业职业群体的护士应具备足够的知识和技能水平。方法:在这项回顾性描述研究中,对高等教育委员会国家论文中心与该主题相关的研究生(硕士-博士)论文进行了审查,以确定有关症状管理的研究。结果如下搜索关键词为 "症状"、"症状管理 "和 "护理"。经检索,共获得 7 篇硕士论文和 16 篇博士论文,共计 23 篇论文。结果发现,65.19%(n=15)的论文是在最近 5 年内完成的,39.19%(n=9)的论文根据研究设计进行了随机研究设计,91.30%(n=21)的样本组由患者组成,47.82%(n=11)的研究为证据 2 级别。结论在近几年进行的论文中,我们发现许多研究都是针对个人和护士的症状管理知识水平进行的。由于论文中随机对照研究的数量较多,建议进行描述性研究。
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引用次数: 0
Adölesanlarda Teknoloji Bağımlılığı 青少年沉迷于技术
Pub Date : 2023-09-08 DOI: 10.55517/mrr.1232796
Ahmet TİMUR, Salih METİN, Betül BAKIŞ
Amaç: Bu çalışmanın amacı adölesanlarda internet bağımlılığı düzeylerinin ve ilişkili faktörlerin belirlenmesi, riskli gruplara psikososyal danışmanlık hizmeti verilerek öğrenci ve ailelerine internet bağımlılığı konusunda farkındalık eğitimlerinin düzenlenmesidir. Yöntem: Araştırmaya Nisan 2018 tarihinde Bursa Ticaret ve Sanayi Odası (BTSO) Eğitim Vadisi Okulları'nda eğitim gören adölesan yaş grubu öğrencilerinde başlanmıştır. BTSO Eğitim Vadisi Okulları'nda öğrenim gören 2452 adölesan öğrenciye ulaşmak hedeflenmiştir. Devamsız öğrenciler, iki kez görüşmeye gidilip ulaşılamayan öğrenciler ve çalışmaya katılmayı kabul etmeyen öğrenciler nedeniyle 2107 öğrenciye yüz yüze anket uygulanmıştır. Çalışmada veri toplama aracı olarak 2 bölümden oluşan anket formu kullanılmıştır. Birinci bölüm sosyo-demografik değişkenlerden, ikinci bölüm geçerlilik ve güvenilirlik çalışması Kayri ve ark. tarafından yapılan ‘’İnternet Bağımlılık Ölçeği’’ kullanılmıştır. Bulgular: İnternet bağımlılığı ile ilişkili faktörler; öğrenim gördüğü lise türü, persentil değeri, yaş grubu, günlük internet kullanım süresi ve kişisel cep telefonuna sahip olma olarak bulundu (p0.05).Sonuç: Literatürle benzeşen birçok bulgumuza rağmen literatürden farklı bulduğumuz bulgularımızı anlamlandırmaya çalıştık. Birçok neden ortaya atılsa da ulaşılabilirliğin artığı ve küreselleştiğimiz günümüzde elimizdeki küçük bir telefonla bir mesaj ile kıtalar arası haberleşmenin, aklımıza gelenin soracağımız başucu kitaplığı gibi olan arama motorlarının ve belki de birçok kolaylığı hayatımıza sokan internetin de birçok madde gibi patolojik kullanımının yol açacağı hastalıkları yakın gelecekte göreceğiz. Bu bağımlılığın şiddete eğilimi, asosyal, antisosyal davranışları tetiklediği çeşitli ruhsal hastalıklara zemin hazırladığı düşünülecek olursa koruyucu hekimliğin temeli olan aile hekimliği ve halk sağlığı branşlarının bu konu üzerinde fazlaca düşünmesi ve çözüm önerileri getirmeye çalışması yararlı olacaktır.
研究目的本研究旨在确定青少年的网络成瘾水平及相关因素,为高危人群提供心理咨询服务,并为学生及其家人组织网络成瘾认知培训。研究方法:研究于2018年4月开始,对象为布尔萨工商会(BTSO)教育谷学校的青少年学生。研究目标是接触到在布尔萨工商会教育谷学校就读的 2452 名青少年学生。由于缺席的学生、无法两次联系到的学生和不同意参与研究的学生,2107 名学生接受了面对面问卷调查。研究使用了由两部分组成的问卷作为数据收集工具。第一部分包括社会人口变量,第二部分包括 "网络成瘾量表",Kayri 等人对该量表的有效性和可靠性进行了研究。研究结果发现与网络成瘾相关的因素有高中类型、百分位值、年龄组、每天上网时间和拥有个人手机(P0.05):尽管有许多研究结果与文献相似,但我们发现这些结果与文献不同,因此我们试图对这些结果进行分析。 尽管已经提出了许多原因,但在不久的将来,我们将看到因病态使用互联网而引发的疾病,因为互联网提高了可访问性和全球化程度,我们手中的小手机只需一条信息就能在各大洲之间进行交流,搜索引擎就像床边图书馆,我们可以询问任何我们能想到的问题,也许互联网给我们的生活带来了许多便利,就像许多物质一样。考虑到这种成瘾会引发暴力、非社会和反社会行为倾向,并为各种精神疾病埋下隐患,作为预防医学基础的家庭医学和公共卫生分支机构有必要思考这一问题,并尝试提出解决方案。
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引用次数: 0
Postmortem of Retracted Scientific Publications from Türkiye 《<s:1> rkiye》撤稿科学出版物事后分析
Pub Date : 2023-09-04 DOI: 10.55517/mrr.1303112
Fahad AHMED, Yazgı Beriy ALTUN GÜZELDEREN, Şefik YURDAKUL, Parısa POURALI KAHRIZ, Khalıd Mahmood KHAWAR
Aim: These days the number of scientific publications is crucial in career advancements and respect in the scientific community. The researchers focus on increasing the number of publications per year, which sometimes compromises the quality of publications. This study aimed to investigate the characteristics of retracted publications with contributions from Turkish authors. Methods: PubMed, Scopus, and Web of Science databases were searched with a combination of MeSH terms and free words relevant to “retracted publication/s” and “Turkey.” The inclusion criteria were (i) retracted publication and (ii) any authors of the study having affiliation with an institution in Turkey. Bibliographic information of selected publications was extracted. Results: A total of 147 publications were retrieved from three databases. The earliest retracted article was published in 1996, followed by an increasing trend of retracted publications. The study showed 106 (72.1%) articles have full-text Access. Overall 127 scientific journals have published these articles. Scientific Reports and Aesthetic Plastic Surgery were the top journals with four retracted publications. Hacettepe University, was the lead institute, contributing seven publications. The most common reasons for retractions were duplication 50 (34%) and most retracted notices were issued by editor 63 (42.9%). The majority of publications were from Medical Science 93 (63.3% paper) and the highest number, 44 were from surgery and allied. Turkish authors had international collaborations with 20 countries. Conclusion: The number of retracted publications is not high, the trend is increasing. To overcome this, research methodology and research ethics training are crucial.
目的:如今,科学出版物的数量对职业发展和科学界的尊重至关重要。研究人员专注于增加每年的出版物数量,这有时会损害出版物的质量。本研究旨在调查土耳其作者发表的撤回出版物的特征。方法:检索PubMed、Scopus和Web of Science数据库中与“撤回出版物”和“土耳其”相关的MeSH术语和自由词。纳入标准为:(i)撤回发表和(ii)研究的任何作者与土耳其的机构有关联。提取选定出版物的书目信息。结果:从3个数据库中共检索到文献147篇。最早被撤稿的文章发表于1996年,此后撤稿数量呈上升趋势。研究显示,106篇(72.1%)文章具有全文访问。总共有127种科学期刊发表了这些文章。《科学报告》(Scientific Reports)和《美容整形外科》(Aesthetic Plastic Surgery)是排名靠前的期刊,有4篇论文被撤稿。Hacettepe大学是主要研究机构,发表了7篇论文。撤稿最常见的原因是重复50篇(34%),撤稿通知大多数是由编辑63篇(42.9%)发出的。大多数出版物来自医学科学93(63.3%),最多的44篇来自外科及相关领域。土耳其作家与20个国家有国际合作。结论:撤稿数量不高,呈上升趋势。为了克服这一点,研究方法和研究伦理培训至关重要。
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引用次数: 0
Polikistik Over Sendromlu (PKOS) Kadınlarda Anormal MiRNA Ekspresyonu 多囊卵巢综合征(PCOS)妇女体内 MiRNA 的异常表达
Pub Date : 2023-09-01 DOI: 10.55517/mrr.1324616
Sude TOPKARAOĞLU, Gulam HEKİMOĞLU
Polycystic ovary syndrome (PCOS) is a debilitating endocrine and metabolic disorder that affects a large proportion of women in their reproductive years. It differs by a range of symptoms including polycystic ovary appearance, hyperandrogenism, chronic anovulation, insulin resistance, and obesity. Despite years of research, the exact cause of PCOS remains elusive, but recent studies have suggested that epigenetic mechanisms may play a significant role in its pathogenesis. Of particular interest are micro-RNAs (miRNAs), short non-coding RNAs that are transcribed from DNA but not translated into protein. Recent research has demonstrated that abnormal expression of miRNAs is present in PCOS and may contribute to the development and progression of the disease. This review aims to provide an in-depth analysis of the current knowledge and challenges related to abnormal miRNA expression in PCOS, shedding light on a potential avenue for targeted therapies and improved management of this debilitating condition. The review summarizes the findings from various studies that have investigated the role of miRNAs in PCOS. It discusses the specific miRNAs that have been found to be dysregulated in PCOS and their potential impact on the pathophysiology of the disease. The review also highlights the challenges associated with studying miRNAs, including the complexity of their regulation and the need for standardized methodologies for miRNA profiling. Based on the available evidence, abnormal expression of miRNAs appears to be a significant contributor to the development and progression of PCOS. Targeting these dysregulated miRNAs could offer new therapeutic strategies for the management of PCOS. Biomarkers and gene therapies associated with miRNA may improve the accuracy and effectiveness of PCOS diagnosis and treatment. However, further research is needed to fully understand the functional roles of specific miRNAs and their potential as diagnostic or therapeutic targets.
多囊卵巢综合征(PCOS)是一种使人衰弱的内分泌和代谢紊乱,影响了很大一部分育龄妇女。不同的症状包括多囊卵巢、高雄激素、慢性无排卵、胰岛素抵抗和肥胖。尽管多年的研究,多囊卵巢综合征的确切原因仍然难以捉摸,但最近的研究表明,表观遗传机制可能在其发病机制中发挥重要作用。特别令人感兴趣的是微rna (miRNAs),一种从DNA转录但不翻译成蛋白质的短非编码rna。最近的研究表明,mirna的异常表达存在于多囊卵巢综合征,并可能有助于疾病的发生和进展。本综述旨在深入分析PCOS中miRNA异常表达的现有知识和挑战,为这种衰弱性疾病的靶向治疗和改善管理提供潜在的途径。本文综述了mirna在PCOS中作用的各种研究结果。它讨论了在多囊卵巢综合征中被发现失调的特定mirna及其对疾病病理生理的潜在影响。该综述还强调了与研究miRNA相关的挑战,包括其调控的复杂性和对miRNA分析的标准化方法的需求。根据现有的证据,mirna的异常表达似乎是PCOS发生和发展的重要因素。靶向这些失调的mirna可能为PCOS的治疗提供新的治疗策略。与miRNA相关的生物标志物和基因治疗可提高PCOS诊断和治疗的准确性和有效性。然而,需要进一步的研究来充分了解特定mirna的功能作用及其作为诊断或治疗靶点的潜力。
{"title":"Polikistik Over Sendromlu (PKOS) Kadınlarda Anormal MiRNA Ekspresyonu","authors":"Sude TOPKARAOĞLU, Gulam HEKİMOĞLU","doi":"10.55517/mrr.1324616","DOIUrl":"https://doi.org/10.55517/mrr.1324616","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a debilitating endocrine and metabolic disorder that affects a large proportion of women in their reproductive years. It differs by a range of symptoms including polycystic ovary appearance, hyperandrogenism, chronic anovulation, insulin resistance, and obesity. Despite years of research, the exact cause of PCOS remains elusive, but recent studies have suggested that epigenetic mechanisms may play a significant role in its pathogenesis. Of particular interest are micro-RNAs (miRNAs), short non-coding RNAs that are transcribed from DNA but not translated into protein. Recent research has demonstrated that abnormal expression of miRNAs is present in PCOS and may contribute to the development and progression of the disease. This review aims to provide an in-depth analysis of the current knowledge and challenges related to abnormal miRNA expression in PCOS, shedding light on a potential avenue for targeted therapies and improved management of this debilitating condition. The review summarizes the findings from various studies that have investigated the role of miRNAs in PCOS. It discusses the specific miRNAs that have been found to be dysregulated in PCOS and their potential impact on the pathophysiology of the disease. The review also highlights the challenges associated with studying miRNAs, including the complexity of their regulation and the need for standardized methodologies for miRNA profiling. Based on the available evidence, abnormal expression of miRNAs appears to be a significant contributor to the development and progression of PCOS. Targeting these dysregulated miRNAs could offer new therapeutic strategies for the management of PCOS. Biomarkers and gene therapies associated with miRNA may improve the accuracy and effectiveness of PCOS diagnosis and treatment. However, further research is needed to fully understand the functional roles of specific miRNAs and their potential as diagnostic or therapeutic targets.","PeriodicalId":484823,"journal":{"name":"Medical Research Reports","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135688541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Klinik ve Radyolojik Bulgularla Trigeminal Nevralji: 3 Olgu Sunumu 三叉神经痛的临床和放射学检查结果:3 个病例报告
Pub Date : 2023-08-31 DOI: 10.55517/mrr.1173001
Merve DALDAL, Sümeyye COŞGUN BAYBARS, Merve Hacer DURAN
Trigeminal neuralgia (TN) is a psychoneurotic disease involving the sensory branches of the trigeminal nerve (V) and characterized by severe and persistent pain. Pain, which is the most typical feature of the disease, is described by patients as short or long term, electric shock, burning, stinging and throbbing. Pain may involve all sensory branches of the nerve, and it is more common in areas innervated by the maxillary (V2) and mandibular (V3) nerve. Therefore, meticulous and regular follow-ups performed by dentists and oral surgeons and accurate examination of the cranial nerves are very important in order to avoid inappropriate treatments in patients who apply to dentists due to toothaches confused with facial pain. Otherwise, if the correct clinical history and pain type are not questioned, root canal treatments or even tooth extractions can be applied to patients due to misdiagnosis, also the pain does not go away. As can be seen in the three cases discussed in this article, it has been determined that many of the patients' teeth were treated with root canal treatment before the diagnosis of TN, and worse they were removed. It is very important for dentists to be careful about the distinction between TN-induced pain and toothache, in order to prevent incorrect treatments to be applied to patients.
三叉神经痛(TN)是一种累及三叉神经感觉分支的精神神经性疾病,以严重和持续的疼痛为特征。疼痛是本病最典型的特征,被患者描述为短期或长期的电击、灼烧、刺痛和悸动。疼痛可累及所有感觉神经分支,在上颌神经(V2)和下颌神经(V3)支配的区域更为常见。因此,牙医和口腔外科医生进行细致和定期的随访和准确的脑神经检查是非常重要的,以避免因牙痛与面部疼痛混淆而向牙医申请治疗的患者。否则,如果不质疑正确的临床病史和疼痛类型,因误诊而对患者进行根管治疗甚至拔牙,疼痛也不会消失。从本文讨论的三个病例中可以看出,在诊断为TN之前,很多患者的牙齿都进行了根管治疗,更糟糕的是被拔除了。对于牙医来说,小心区分tn引起的疼痛和牙痛是非常重要的,以防止对患者应用错误的治疗方法。
{"title":"Klinik ve Radyolojik Bulgularla Trigeminal Nevralji: 3 Olgu Sunumu","authors":"Merve DALDAL, Sümeyye COŞGUN BAYBARS, Merve Hacer DURAN","doi":"10.55517/mrr.1173001","DOIUrl":"https://doi.org/10.55517/mrr.1173001","url":null,"abstract":"Trigeminal neuralgia (TN) is a psychoneurotic disease involving the sensory branches of the trigeminal nerve (V) and characterized by severe and persistent pain. Pain, which is the most typical feature of the disease, is described by patients as short or long term, electric shock, burning, stinging and throbbing. Pain may involve all sensory branches of the nerve, and it is more common in areas innervated by the maxillary (V2) and mandibular (V3) nerve. Therefore, meticulous and regular follow-ups performed by dentists and oral surgeons and accurate examination of the cranial nerves are very important in order to avoid inappropriate treatments in patients who apply to dentists due to toothaches confused with facial pain. Otherwise, if the correct clinical history and pain type are not questioned, root canal treatments or even tooth extractions can be applied to patients due to misdiagnosis, also the pain does not go away. As can be seen in the three cases discussed in this article, it has been determined that many of the patients' teeth were treated with root canal treatment before the diagnosis of TN, and worse they were removed. It is very important for dentists to be careful about the distinction between TN-induced pain and toothache, in order to prevent incorrect treatments to be applied to patients.","PeriodicalId":484823,"journal":{"name":"Medical Research Reports","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136036084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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