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Insights from the Road Damage Detection Challenge Series (2018–2024) 道路损伤检测挑战系列(2018-2024)
IF 23.9 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2025-10-13 DOI: 10.1038/s42256-025-01132-5
Deeksha Arya, Hiroya Maeda, Yoshihide Sekimoto
The organizers reflect on how a multi-year, multi-country benchmark aligned AI research in road damage detection with practical and regional constraints, steering it towards deployment relevance.
组织者反思了多年来,多国基准如何将道路损伤检测方面的人工智能研究与实际和区域限制相结合,并将其转向部署相关性。
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引用次数: 0
Rethinking human roles in AI warfare 重新思考人类在人工智能战争中的角色
IF 23.9 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2025-10-13 DOI: 10.1038/s42256-025-01123-6
Jovana Davidovic
Most policy proposals aimed at managing the risks of artificial intelligence (AI)-enabled weapons rely heavily on meaningful human control or appropriate human judgment for risk mitigation. This Comment argues that there are various ways humans can exert such control over AI, and that developing a careful taxonomy of these is necessary for building actionable risk-mitigation policies for warfighting AI.
大多数旨在管理人工智能(AI)武器风险的政策建议严重依赖有意义的人为控制或适当的人为判断来减轻风险。这篇评论认为,人类可以通过各种方式对人工智能施加这种控制,并且对这些方式进行仔细的分类对于构建可操作的风险缓解政策对于对抗人工智能是必要的。
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引用次数: 0
An adaptive autoregressive diffusion approach to design active humanized antibodies and nanobodies 设计活性人源化抗体和纳米体的自适应自回归扩散方法
IF 23.9 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2025-10-01 DOI: 10.1038/s42256-025-01120-9
Jian Ma, Fandi Wu, Tingyang Xu, Shaoyong Xu, Wei Liu, Liang Yan, Minghao Qu, Xiaoke Yang, Qifeng Bai, Junyu Xiao, Jianhua Yao
Humanization is a critical process in designing antibodies and nanobodies for clinical trials. Developing widely recognized deep learning frameworks for this task remains valuable yet challenging. Here, inspired by the success of diffusion models, we introduce HuDiff, an adaptive diffusion approach for humanizing antibodies and nanobodies from scratch, referred to as HuDiff-Ab and HuDiff-Nb. This approach initiates humanization exclusively with complementarity-determining region sequences, eliminating the need for humanized templates. On public benchmarks, HuDiff-Ab generates humanized antibodies that more closely resemble experimentally humanized sequences than existing models. Similarly, HuDiff-Nb produces nanobodies with higher humanness scores and nativeness than alternative methods. We apply HuDiff to humanize a murine antibody targeting the SARS-CoV-2 receptor-binding domain and two alpaca-derived nanobodies, one targeting the receptor-binding domain and the other targeting the C345c domain of C3. Bio-layer interferometry shows the best-performing humanized antibody retains binding affinity comparable to the parental antibody (0.15 nM versus 0.12 nM). Both humanized nanobodies maintain binding to their respective antigens, with the best-performing one exhibiting a substantially enhanced affinity (2.52 nM versus 5.47 nM), corresponding to a 54% improvement over the parental nanobody. Neutralization assays confirm that the humanized sequences effectively neutralize the virus. These results demonstrate that HuDiff improves antibody and nanobody humanness while preserving or enhancing binding and function. Jian Ma et al. present HuDiff, a diffusion-based deep learning framework that humanizes antibodies and nanobodies (a small type of antibody) without templates. The model achieves improved humanness while preserving or enhancing binding strength, and the authors show promising results in virus neutralization experiments.
人源化是设计用于临床试验的抗体和纳米体的关键过程。为这项任务开发广泛认可的深度学习框架仍然很有价值,但也很有挑战性。在这里,受扩散模型成功的启发,我们介绍了HuDiff,一种从头开始人源化抗体和纳米体的自适应扩散方法,称为HuDiff- ab和HuDiff- nb。这种方法只通过互补性决定区域序列启动人性化,消除了对人性化模板的需要。在公共基准上,HuDiff-Ab产生的人源化抗体比现有模型更接近于实验人源化序列。同样,与其他方法相比,huff - nb产生的纳米体具有更高的人类得分和原生性。我们利用HuDiff人源化了一种靶向SARS-CoV-2受体结合域的小鼠抗体和两个羊驼衍生的纳米体,一个靶向受体结合域,另一个靶向C3的C345c结构域。生物层干涉法显示,表现最好的人源化抗体与亲本抗体具有相当的结合亲和力(0.15 nM对0.12 nM)。两种人源化纳米体都保持了与各自抗原的结合,表现最好的纳米体表现出显著增强的亲和力(2.52 nM对5.47 nM),比亲本纳米体提高了54%。中和试验证实人源化的序列能有效中和病毒。这些结果表明,HuDiff在保留或增强结合和功能的同时,改善了抗体和纳米体的人源性。Jian Ma等人提出了HuDiff,这是一个基于扩散的深度学习框架,可以在没有模板的情况下人源化抗体和纳米体(一种小型抗体)。该模型在保持或增强结合强度的同时,改善了人情性,并在病毒中和实验中取得了令人满意的结果。
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引用次数: 0
An integrated framework to accelerate protein design through mutagenesis 通过诱变加速蛋白质设计的集成框架
IF 23.9 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2025-09-29 DOI: 10.1038/s42256-025-01118-3
Yuchi Qiu
Designing and optimizing proteins by mutagenesis suffers from the overwhelming space of possible variants. A recent study developed µProtein, a reinforcement learning model coupled with a protein language model as a surrogate oracle, to accelerate this process towards high-functioning proteins.
通过诱变来设计和优化蛋白质受到可能变异的巨大空间的影响。最近的一项研究开发了µProtein,这是一种强化学习模型,结合了蛋白质语言模型作为代理oracle,以加速这一过程,从而获得高功能蛋白质。
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引用次数: 0
Efficient protein structure generation with sparse denoising models 基于稀疏去噪模型的高效蛋白质结构生成
IF 23.9 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2025-09-24 DOI: 10.1038/s42256-025-01100-z
Michael Jendrusch, Jan O. Korbel
Proteins play diverse roles in all domains of life and are extensively harnessed as biomolecules in biotechnology, with applications spanning from fundamental research to biomedicine. Therefore, there is considerable interest in computationally designing proteins with specified properties. Protein structure generative models provide a means to design protein structures in a controllable manner and have been successfully applied to address various protein design tasks. Such models are paired with protein sequence and structure predictors to produce and select protein sequences for experimental testing. However, current protein structure generators face important limitations for proteins with more than 400 amino acids and require retraining for protein design tasks unseen during model training. To address the first issue, we introduce salad, a family of sparse all-atom denoising models for protein structure generation. Our models are smaller and faster than the state of the art and matching or improving design quality, successfully generating structures for protein lengths up to 1,000 amino acids. To address the second issue, we combine salad with structure editing, a sampling strategy for expanding the capability of protein denoising models to unseen tasks. We apply our approach to a variety of challenging protein design tasks, from generating protein scaffolds containing functional protein motifs (motif scaffolding) to designing proteins capable of adopting multiple distinct folds under different conditions (multi-state protein design), demonstrating the flexibility of salad and structure editing. A small and fast diffusion model is presented, which is able to efficiently generate long protein backbones.
蛋白质在生命的各个领域发挥着不同的作用,作为生物分子在生物技术中被广泛利用,应用范围从基础研究到生物医学。因此,人们对计算设计具有特定性质的蛋白质非常感兴趣。蛋白质结构生成模型提供了一种以可控方式设计蛋白质结构的手段,并已成功地应用于解决各种蛋白质设计任务。这些模型与蛋白质序列和结构预测因子配对,以产生和选择用于实验测试的蛋白质序列。然而,目前的蛋白质结构生成器面临着超过400个氨基酸的蛋白质的重要限制,并且需要对模型训练中看不到的蛋白质设计任务进行再训练。为了解决第一个问题,我们引入了salad,这是一种用于蛋白质结构生成的稀疏全原子去噪模型。我们的模型比目前最先进的模型更小、更快,并且匹配或提高了设计质量,成功地生成了长达1000个氨基酸的蛋白质结构。为了解决第二个问题,我们将沙拉与结构编辑结合起来,结构编辑是一种采样策略,用于将蛋白质去噪模型的能力扩展到看不见的任务。我们将我们的方法应用于各种具有挑战性的蛋白质设计任务,从生成含有功能蛋白质基序的蛋白质支架(基序脚手架)到设计能够在不同条件下采用多种不同折叠的蛋白质(多状态蛋白质设计),展示了色拉和结构编辑的灵活性。提出了一种小而快速的扩散模型,该模型能够有效地生成长蛋白骨架。
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引用次数: 0
Towards reproducible robotics research 朝着可复制机器人研究的方向
IF 23.9 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2025-09-23 DOI: 10.1038/s42256-025-01114-7
Fabio Bonsignorio, Angel P. del Pobil, Enrica Zereik
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引用次数: 0
A multi-joint soft exosuit improves shoulder and elbow motor functions in individuals with spinal cord injury 一种多关节软外套可以改善脊髓损伤患者的肩部和肘部运动功能
IF 23.9 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2025-09-22 DOI: 10.1038/s42256-025-01105-8
Roberto Ferroni, Gaetano D’Avola, Giorgia Sciarrone, Gabriele Righi, Claudia De Santis, Jacopo Carpaneto, Marta Gandolla, Giulio Del Popolo, Silvestro Micera, Tommaso Proietti
Spinal cord injury (SCI) disrupts neuromuscular control, severely affecting independence and quality of life. Although upper limb wearable robots hold considerable promise for functional restoration, most existing prototypes have been validated minimally in people with SCI and target almost exclusively hand opening and closing. We introduce a lightweight, modular assistive soft exosuit that simultaneously and automatically supports shoulder abduction and elbow flexion or extension movements using lightweight fabric-based pneumatic actuators, controlled through inertial sensors. The individual elbow modules were first validated in 11 healthy volunteers, and subsequently tested, together with the shoulder module, in 15 individuals with cervical SCI (C4–C7, AIS A–D). In the SCI participants, exosuits assistance resulted in increased static endurance time (by more than 250%), and lower activity of the primary muscles involved in dynamic tasks (by up to 50%). The two SCI participants retaining prehensile capability also improved their scores in the box and block test when assisted. Moreover, the soft actuation provided a safe, comfortable and easy-to-use solution that was positively appreciated by the participants. Collectively, these results provide encouraging evidence that exosuits can augment upper limb motor performance, and may ultimately translate into greater functional independence and quality of life for the SCI population. A lightweight, modular assistive soft exosuit is introduced, which supports shoulder and elbow movement in individuals with cervical spinal cord injury. The device enhances endurance and range of motion, reduces muscle effort and improves clinical test scores.
脊髓损伤(SCI)破坏神经肌肉控制,严重影响独立性和生活质量。尽管上肢可穿戴机器人在功能恢复方面具有相当大的前景,但大多数现有的原型已经在脊髓损伤患者中得到了最低限度的验证,并且几乎只针对手的打开和关闭。我们推出了一款轻量级的模块化辅助软性外骨骼服,该外骨骼服使用基于轻质织物的气动致动器,通过惯性传感器控制,同时自动支持肩部外展和肘关节弯曲或伸展运动。首先在11名健康志愿者中验证了单个肘关节模块,随后在15名颈椎脊髓损伤患者(C4-C7, AIS A-D)中测试了肩部模块。在脊髓损伤参与者中,外伤服的帮助增加了静态耐力时间(超过250%),并降低了参与动态任务的主要肌肉的活动(高达50%)。保留抓握能力的两名脊髓损伤参与者在辅助下也提高了他们在盒子和方块测试中的得分。此外,软驱动提供了一个安全、舒适和易于使用的解决方案,得到了参与者的积极赞赏。总的来说,这些结果提供了令人鼓舞的证据,表明外伤服可以增强上肢运动能力,并可能最终转化为脊髓损伤患者更大的功能独立性和生活质量。介绍了一种轻量级的模块化辅助软性外服,它支持颈脊髓损伤患者的肩部和肘部运动。该设备增强了耐力和活动范围,减少了肌肉消耗,提高了临床测试分数。
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引用次数: 0
Error-controlled non-additive interaction discovery in machine learning models 机器学习模型中误差控制的非加性交互发现
IF 23.9 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2025-09-22 DOI: 10.1038/s42256-025-01086-8
Winston Chen, Yifan Jiang, William Stafford Noble, Yang Young Lu
Machine learning (ML) models are powerful tools for detecting complex patterns, yet their ‘black-box’ nature limits their interpretability, hindering their use in critical domains like healthcare and finance. Interpretable ML methods aim to explain how features influence model predictions but often focus on univariate feature importance, overlooking complex feature interactions. Although recent efforts extend interpretability to feature interactions, existing approaches struggle with robustness and error control, especially under data perturbations. In this study, we introduce Diamond, a method for trustworthy feature interaction discovery. Diamond uniquely integrates the model-X knockoffs framework to control the false discovery rate, ensuring a low proportion of falsely detected interactions. Diamond includes a non-additivity distillation procedure that refines existing interaction importance measures to isolate non-additive interaction effects and preserve false discovery rate control. This approach addresses the limitations of off-the-shelf interaction measures, which, when used naively, can lead to inaccurate discoveries. Diamond’s applicability spans a broad class of ML models, including deep neural networks, transformers, tree-based models and factorization-based models. Empirical evaluations on both simulated and real datasets across various biomedical studies demonstrate its utility in enabling reliable data-driven scientific discoveries. Diamond represents a significant step forward in leveraging ML for scientific innovation and hypothesis generation. Diamond, a statistically rigorous method, is capable of finding meaningful feature interactions within machine learning models, making black-box models more interpretable for science and medicine.
机器学习(ML)模型是检测复杂模式的强大工具,但它们的“黑箱”性质限制了它们的可解释性,阻碍了它们在医疗保健和金融等关键领域的应用。可解释的机器学习方法旨在解释特征如何影响模型预测,但往往侧重于单变量特征的重要性,忽略了复杂的特征相互作用。虽然最近的努力将可解释性扩展到特征交互,但现有的方法在鲁棒性和误差控制方面存在困难,特别是在数据扰动下。在本研究中,我们引入了一种可信特征交互发现方法Diamond。Diamond独特地集成了model-X仿冒框架,以控制错误发现率,确保低比例的错误检测交互。Diamond包括一个非加性蒸馏程序,该程序改进了现有的相互作用重要性度量,以隔离非加性相互作用效应并保持错误发现率控制。这种方法解决了现成的交互度量的局限性,如果使用不当,可能会导致不准确的发现。Diamond的适用性涵盖了广泛的机器学习模型,包括深度神经网络、变压器、基于树的模型和基于分解的模型。对各种生物医学研究的模拟和真实数据集的经验评估表明,它在实现可靠的数据驱动的科学发现方面具有实用价值。戴蒙德代表了利用机器学习进行科学创新和假设生成的重要一步。Diamond是一种统计严谨的方法,能够在机器学习模型中找到有意义的特征交互,使黑盒模型更易于科学和医学解释。
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引用次数: 0
Modelling neural coding in the auditory midbrain with high resolution and accuracy 高分辨率、高准确度的中脑听觉神经编码建模
IF 23.9 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2025-09-18 DOI: 10.1038/s42256-025-01104-9
Fotios Drakopoulos, Lloyd Pellatt, Shievanie Sabesan, Yiqing Xia, Andreas Fragner, Nicholas A. Lesica
Computational models of auditory processing can be valuable tools for research and technology development. Models of the cochlea are highly accurate and widely used, but models of the auditory brain lag far behind in both performance and penetration. Here we present ICNet, a convolutional encoder–decoder model of neural coding in the inferior colliculus. We developed ICNet using large-scale intracranial recordings from anaesthetized gerbils, addressing three key modelling challenges that are common across all sensory systems: capturing the full statistical structure of neuronal response patterns; accounting for physiological and experimental non-stationarity; and extracting features of sensory processing that are shared across different brains. ICNet provides highly accurate simulation of multi-unit neural responses to a wide range of complex sounds, including near-perfect responses to speech. It also reproduces key neurophysiological phenomena such as forward masking and dynamic range adaptation. ICNet can be used to simulate activity from thousands of neural units or to provide a compact representation of early central auditory processing through its latent dynamics, facilitating a wide range of hearing and audio applications. It can also serve as a foundation core, providing a baseline neural representation for models of active listening or higher-level auditory processing. Drakopoulos et al. present a model that captures the transformation from sound waves to neural activity patterns underlying early auditory processing. The model reproduces neural responses to a range of complex sounds and key neurophysiological phenomena.
听觉处理的计算模型可以成为研究和技术开发的宝贵工具。耳蜗模型精度高,应用广泛,但听觉脑模型在性能和穿透性方面都远远落后。在这里,我们提出了ICNet,一个卷积编码器-解码器模型的神经编码在下丘。我们使用麻醉沙鼠的大规模颅内记录开发了ICNet,解决了所有感觉系统中常见的三个关键建模挑战:捕获神经元反应模式的完整统计结构;考虑生理和实验的非平稳性;提取不同大脑共有的感觉处理特征。ICNet提供了对各种复杂声音的多单元神经反应的高度精确模拟,包括对语音的近乎完美的反应。它还再现了关键的神经生理现象,如前向掩蔽和动态范围适应。ICNet可用于模拟来自数千个神经单元的活动,或通过其潜在动态提供早期中枢听觉处理的紧凑表示,促进广泛的听力和音频应用。它也可以作为基础核心,为主动倾听模型或更高层次的听觉处理提供基线神经表征。Drakopoulos等人提出了一个模型,该模型捕捉了从声波到早期听觉处理背后的神经活动模式的转换。该模型再现了对一系列复杂声音和关键神经生理现象的神经反应。
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引用次数: 0
Author Correction: Deep learning-based prediction of the selection factors for quantifying selection in immune receptor repertoires 作者更正:基于深度学习的选择因子预测,用于量化免疫受体库的选择
IF 23.9 1区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2025-09-17 DOI: 10.1038/s42256-025-01128-1
Yuepeng Jiang, Pingping Zhang, Miaozhe Huo, Shuai Cheng Li
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引用次数: 0
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Nature Machine Intelligence
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