Journal of Integrative Medicine-Jim最新文献

英文中文

Acupuncture activates vagus nerve-macrophage axis and improves cardiac electrophysiology and inflammatory response in rats with atrial fibrillation via α7nAChR-JAK2/STAT3 pathway 针刺通过α7nAChR-JAK2/STAT3通路激活迷走神经-巨噬细胞轴，改善心房颤动大鼠心脏电生理和炎症反应。

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2025-07-01 DOI: 10.1016/j.joim.2025.06.002

Zhi-han Li , Wen-min Yang , Qi Huang , Guang-xia Shi , Cun-zhi Liu , Yu-qin Zhang

Objective

The occurrence and development of atrial fibrillation (AF) are influenced by the autonomic nervous system and inflammation. Acupuncture is an effective treatment for AF. This study explored the protective effects of acupuncture in a rat model of paroxysmal AF and investigated its mechanisms.

Methods

Male Sprague-Dawley rats (n = 130) were randomly divided into blank control (Con), sham operation (Sham), AF, and acupuncture treatment (Acu) groups. A paroxysmal AF model was established by rapid atrial pacing through the jugular vein. Rats in the Acu group were immobilized to receive acupuncture treatment at Neiguan acupoint (PC6) for 20 min daily for seven days. The other groups were immobilized for the same duration over the treatment period but did not receive acupuncture. The AF induction rate, AF duration, cardiac electrophysiological parameters, and heart rate variability were evaluated by monitoring surface electrocardiogram and vagus nerve discharge signals. After the intervention, the rats were euthanized, and atrial morphology was assessed using haematoxylin and eosin staining. The expression of macrophage F4/80 antigen (F4/80) and cluster of differentiation (CD) 86 in atrial myocardial tissue was detected using immunohistochemistry, immunofluorescence and flow cytometry. The expression levels or contents of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), α7 nicotinic acetylcholine receptor (α7nAChR), phosphorylated Janus kinase 2 (p-JAK2), and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in atrial myocardial tissue were detected using Western blotting, reverse transcription-quantitative polymerase chain reaction, or enzyme-linked immunosorbent assay. The role of α7nAChR in acupuncture treatment was verified by intraperitoneal injection of the α7nAChR antagonist methyllycaconitine (MLA).

Results

Compared with the AF group, acupuncture significantly reduced AF duration and induction rate, improved cardiac electrophysiology by enhancing vagus nerve activity and regulating autonomic balance. It also decreased the pro-inflammatory M1 macrophage proportion, alleviating myocardial injury and infiltration. MLA weakened acupuncture’s electrophysiological improvement and anti-inflammatory effect. Results suggest that acupuncture triggers the α7nAChR-JAK2/STAT3 pathway and exerts cardioprotection via neuroimmune regulation.

Conclusion

Acupuncture significantly reduced the AF induction rate, shortened AF duration, improved cardiac electrophysiological parameters, enhanced vagus nerve activity, and decreased the expression of pro-inflammatory M1 macrophages and inflammatory factors in rats with paroxysmal AF. Its positive effects are related to the activation of the α7nAChR-mediated JAK2/STAT3 signalling pathway, indicating that the interaction between cardiac vagus nerve and macrophages

目的：心房颤动（AF）的发生和发展受自主神经系统和炎症的影响。针刺是治疗房颤的有效方法。本研究探讨针刺对阵发性房颤大鼠模型的保护作用，并探讨其机制。方法：雄性Sprague-Dawley大鼠130只，随机分为空白对照组（Con）、假手术组（sham）、AF组（AF）和针刺治疗组（Acu）。采用颈静脉快速心房起搏法建立阵发性房颤模型。Acu组大鼠固定于内关穴（PC6），每日20 min，连续7 d。其他组在治疗期间固定相同时间，但不接受针灸。通过监测体表心电图和迷走神经放电信号，评估AF诱导率、AF持续时间、心电生理参数和心率变异性。干预后对大鼠实施安乐死，采用苏木精和伊红染色评价心房形态。采用免疫组织化学、免疫荧光和流式细胞术检测心房心肌组织巨噬细胞F4/80抗原（F4/80）和分化簇（cd86）的表达。采用Western blotting、逆转录-定量聚合酶链反应或酶联免疫吸附法检测心房心肌组织中白细胞介素(IL)-1β、IL-6、肿瘤坏死因子-α (TNF-α)、α7烟碱胆碱受体（α7nAChR）、磷酸化Janus激酶2 （p-JAK2）、磷酸化信号转导和转录激活因子3 （p-STAT3）的表达水平或含量。通过腹腔注射α7nAChR拮抗剂甲基莱卡乌碱（MLA）验证α7nAChR在针刺治疗中的作用。结果：与房颤组比较，针刺可显著缩短房颤持续时间和诱导率，通过增强迷走神经活动和调节自主神经平衡改善心电生理。降低促炎M1巨噬细胞比例，减轻心肌损伤和浸润。MLA减弱了针刺的电生理改善和抗炎作用。提示针刺可触发α7nAChR-JAK2/STAT3通路，通过神经免疫调节发挥心脏保护作用。结论:针刺可显著降低阵发性AF大鼠AF诱导率，缩短AF持续时间，改善心脏电生理参数，增强迷走神经活性，降低促炎M1巨噬细胞及炎症因子的表达，其积极作用与α 7nachr介导的JAK2/STAT3信号通路的激活有关。表明心脏迷走神经与巨噬细胞之间的相互作用可能是针刺预防和治疗房颤的潜在靶点。本文署名：李振华，杨文明，黄强，石桂霞，刘长忠，张永强。针刺通过α7nAChR-JAK2/STAT3通路激活迷走神经-巨噬细胞轴，改善心房颤动大鼠心脏电生理和炎症反应。集成医学[J]；打印前Epub。

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引用次数: 0

Thermal sensitization of acupoints in patients with knee osteoarthritis: A cross-sectional case-control study 膝关节骨关节炎患者穴位热致敏：一项横断面病例对照研究。

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2025-05-01 DOI: 10.1016/j.joim.2025.03.004

Jian-feng Tu , Xue-zhou Wang , Shi-yan Yan , Yi-ran Wang , Jing-wen Yang , Guang-xia Shi , Wen-zheng Zhang , Li-na Jin , Li-sha Yang , Dong-hua Liu , Li-qiong Wang , Bao-hong Mi

Objective

Varied acupoint selections represent a potential cause of the uncertainty surrounding the efficacy of acupuncture for knee osteoarthritis (OA). Skin temperature, a guiding factor for acupoint selection, may help to address this issue. This study explored thermal sensitization of acupoints used for the treatment of knee OA.

Methods

This cross-sectional case-control study enrolled cases aged 45–75 years with symptomatic knee OA and age- and gender-matched non-knee OA controls in a 1:1 ratio. All participants underwent infrared thermographic imaging. The primary outcome was the relative skin temperature of acupoint (STA), and the secondary outcome was the absolute STA of 11 acupoints. The Z test was used to compare the relative and absolute STAs between the groups. Principal component analysis was used to extract the common factors (CFs, acupoint cluster) in the STAs. A general linear model was used to identify factors affecting the STA in the knee OA cases. For the group comparisons of relative STA, P < 0.0045 (adjusted for 11 acupoints through Bonferroni correction) was considered to indicate statistical significance. For other analyses, P < 0.05 was used as the threshold for statistical significance.

Results

The analysis included 308 participants, consisting of 151 cases (mean age: [64.58 ± 6.67] years; male: 25.83%; mean body mass index: [25.70 ± 3.16] kg/m²) and 157 controls (mean age: [63.37 ± 5.96] years; male: 26.11%; mean body mass index: [24.47 ± 2.84] kg/m²). The relative STAs of ST34 (P = 0.0001), EX-LE2 (P < 0.0001), EX-LE5 (P = 0.0006), SP10 (P < 0.0001), BL40 (P = 0.0012) and GB39 (P = 0.0037) were higher in the knee OA group. No difference was found in the STAs of ST35, ST36, SP9, GB33 and GB34. Four CFs were identified for relative STA in both groups. The acupoints within each CF were consistent between the groups. The mean values of the relative STAs across each CF were higher in the knee OA group. In the knee OA cases, no factors were observed to affect the relative STA, while age and gender were found to affect the absolute STA.

Conclusion

Among patients with knee OA, thermal sensitization occurs in the acupoints of the lower extremity, exhibiting localized and regional thermal consistencies. The thermally sensitized acupoints that we identified in this study, ST34, SP10, EX-LE2, EX-LE5, GB39 and BL40, may be good choices for the acupuncture treatment of knee OA.

Please cite this article as: Tu JF, Wang XZ, Yan SY, Wang YR, Yang JW, Shi GX, Zhang WZ, Jing LN, Yang LS, Liu DH, Wang LQ, Mi BH. Thermal sensitization of acupoints in patients with knee osteoarthritis: A cross-sectional case-control study. J Integr Med. 2025; 23(3): 289–296.

目的：不同的穴位选择代表了针灸治疗膝骨关节炎（OA）疗效不确定的潜在原因。皮肤温度是穴位选择的一个指导因素，可能有助于解决这个问题。本研究探讨热致敏穴位用于治疗膝关节OA。方法：本横断面病例对照研究纳入年龄45-75岁的症状性膝关节OA患者和年龄和性别匹配的非膝关节OA对照组，比例为1:1。所有的参与者都进行了红外热成像。主要观察指标为穴位相对皮肤温度（STA），次要观察指标为11个穴位的绝对皮肤温度。采用z检验比较各组间的相对sta和绝对sta。采用主成分分析提取sta的共同因子（CFs，腧穴聚类）。采用一般线性模型确定影响膝关节OA患者STA的因素。相对STA组间比较，P < 0.0045（经11个穴位Bonferroni校正）为有统计学意义。其他分析以P < 0.05为具有统计学意义的阈值。结果：共纳入308例患者，其中151例(平均年龄：[64.58±6.67]岁；男:25.83%;平均体重指数：[25.70±3.16]kg/m2)，对照组157人(平均年龄：[63.37±5.96]岁；男:26.11%;平均体重指数：[24.47±2.84]kg/m2)。膝关节OA组ST34 （P = 0.0001）、EX-LE2 （P < 0.0001）、EX-LE5 （P = 0.0006）、SP10 （P < 0.0001）、BL40 （P = 0.0012）、GB39 （P = 0.0037）的相对sta均较高。ST35、ST36、SP9、GB33、GB34的STAs差异无统计学意义。两组均有4例CFs为相对STA。各组间CF内穴位一致。膝关节OA组各CF的相对sta平均值较高。在膝关节OA病例中，没有观察到影响相对STA的因素，而发现年龄和性别影响绝对STA。结论：膝关节OA患者的热致敏发生在下肢的穴位，表现出局部和区域性的热一致性。我们在本研究中确定的热致敏穴位ST34、SP10、EX-LE2、EX-LE5、GB39和BL40可能是针刺治疗膝关节OA的良好选择。本文署名：涂建峰，王晓忠，闫思义，王彦，杨建伟，石广新，张文忠，景琳，杨立林，刘德辉，王立强，米波波。膝关节骨关节炎患者穴位热致敏：一项横断面病例对照研究。集成医学[J]；打印前Epub。

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引用次数: 0

Cynanchum atratum Bunge and Cynanchum versicolor Bunge for Baiwei: An updated review of their botany, phytochemistry, traditional uses and pharmacological activities 白魏白莲花和白魏白莲花：植物学、植物化学、传统用途和药理活性的最新综述。

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2025-05-01 DOI: 10.1016/j.joim.2025.04.003

Wei Xie , Xin-yang Liu , Xia Li , Yong-sheng Jin

Cynanchum atratum Bunge (C. atratum) and Cynanchum versicolor Bunge (C. versicolor) are two related species that have been used as “Baiwei” (Cynanchi Atrati Radix Et Rhizoma) in traditional medicine in China and other Asian countries for a long time. However, to date, no comprehensive review of C. atratum and C. versicolor has been published. This review provides a comprehensive summary on the botany, phytochemistry, traditional uses and pharmacology of Baiwei; The authors focus especially on the revision of errors in previous articles and reviews, updating information and providing a comparison of C. atratum and C. versicolor. Furthermore, current research reveals significant disparities in the chemical composition and pharmacological effects between C. atratum and C. versicolor. Up to November 2023, 178 compounds have been isolated from C. atratum and C. versicolor, including C₂₁ steroids, acetophenones, alkaloids and volatile oils. These compounds and extracts have been proven to exhibit significant pharmacological activities, including anti-inflammatory, anti-tumor, anti-virus, anti-fungal, memory-enhancing and anti-pyretic action, immune modulatory effects, reducing blood lipid, inhibition of melanin production, and anti-parasitic effects. Therefore, this review presents new insights into these two herbs used as “Baiwei” and further study is warranted to enhance their clinical application.

Please cite this article as: Xie W, Liu XY, Li X, Jin YS. Cynanchum atratum Bunge and Cynanchum versicolor Bunge for Baiwei: An updated review of their botany, phytochemistry, traditional uses and pharmacological activities. J Integr Med. 2025; 23(3): 230–255.

白蜡花（Cynanchum atratum Bunge）和白蜡花（Cynanchum versicolor Bunge）是中国和其他亚洲国家长期以来作为“白蜡花”在传统医学中使用的两个近缘种。然而，到目前为止，还没有对白菖蒲和花菖蒲进行全面的综述。本文对白味的植物学、植物化学、传统用途和药理等方面进行了综述；作者着重于对以前的文章和评论中的错误进行了修订，更新了信息，并提供了白蜡木和花斑木的比较。此外，目前的研究表明，白藜芦醇和花青醇在化学成分和药理作用上存在显著差异。截至2023年11月，共分离得到C21甾类化合物、苯乙酮类化合物、生物碱类化合物和挥发油类化合物178个。这些化合物和提取物已被证明具有显著的药理活性，包括抗炎、抗肿瘤、抗病毒、抗真菌、增强记忆和退热作用、免疫调节作用、降低血脂、抑制黑色素生成和抗寄生虫作用。因此，本文对这两种作为“百味”的中药进行了新的认识，值得进一步研究，以提高其临床应用价值。本文的署名为：谢伟，刘学祥，李鑫，金玉英。白魏白莲花和白魏白莲花：植物学、植物化学、传统用途和药理活性的最新综述。集成医学[J]；打印前Epub。

{"title":"Cynanchum atratum Bunge and Cynanchum versicolor Bunge for Baiwei: An updated review of their botany, phytochemistry, traditional uses and pharmacological activities","authors":"Wei Xie , Xin-yang Liu , Xia Li , Yong-sheng Jin","doi":"10.1016/j.joim.2025.04.003","DOIUrl":"10.1016/j.joim.2025.04.003","url":null,"abstract":"<div><div><em>Cynanchum atratum</em> Bunge (<em>C. atratum</em>) and <em>Cynanchum versicolor</em> Bunge (<em>C. versicolor</em>) are two related species that have been used as “Baiwei” (Cynanchi Atrati Radix Et Rhizoma) in traditional medicine in China and other Asian countries for a long time. However, to date, no comprehensive review of <em>C. atratum</em> and <em>C. versicolor</em> has been published. This review provides a comprehensive summary on the botany, phytochemistry, traditional uses and pharmacology of Baiwei; The authors focus especially on the revision of errors in previous articles and reviews, updating information and providing a comparison of <em>C. atratum</em> and <em>C. versicolor</em>. Furthermore, current research reveals significant disparities in the chemical composition and pharmacological effects between <em>C. atratum</em> and <em>C. versicolor</em>. Up to November 2023, 178 compounds have been isolated from <em>C. atratum</em> and <em>C. versicolor</em>, including C<sub>21</sub> steroids, acetophenones, alkaloids and volatile oils. These compounds and extracts have been proven to exhibit significant pharmacological activities, including anti-inflammatory, anti-tumor, anti-virus, anti-fungal, memory-enhancing and anti-pyretic action, immune modulatory effects, reducing blood lipid, inhibition of melanin production, and anti-parasitic effects. Therefore, this review presents new insights into these two herbs used as “Baiwei” and further study is warranted to enhance their clinical application.</div><div>Please cite this article as: Xie W, Liu XY, Li X, Jin YS. <em>Cynanchum atratum</em> Bunge and <em>Cynanchum versicolor</em> Bunge for Baiwei: An updated review of their botany, phytochemistry, traditional uses and pharmacological activities. <em>J Integr Med</em>. 2025; 23(3): 230–255.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"23 3","pages":"Pages 230-255"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placebo response in sham acupuncture therapy trials for simple obesity: A systematic review and meta-analysis 单纯性肥胖的假针灸治疗试验中的安慰剂反应：系统回顾和荟萃分析。

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2025-05-01 DOI: 10.1016/j.joim.2025.04.007

Ke-jia Liu , Rui-min Jiao , Jing Ji , Wei-wei Yao , Chao-ru Han , Xin-yu Zhao , Jing-jie Zhao

Background

Acupuncture has shown potential therapeutic benefits for individuals with simple obesity. However, some researchers argue that some of the effectiveness of acupuncture may be due to the placebo response.

Objective

To understand the placebo response of acupuncture treatment in simple obesity, a systematic review and meta-analysis was designed based on the comparison between sham acupuncture before and after treatment.

Search strategy

Eight databases (PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure, Wanfang Database, China Biology Medicine Database, and Chinese Scientific Journals Database) were searched from inception to August 1, 2023. The MeSH search terms comprised obesity and acupuncture.

Inclusion criteria

Randomized controlled trials (RCTs) using sham or placebo acupuncture as a control in treating obesity were enrolled.

Data extraction and analysis

Two researchers independently extracted data, and the results were cross-checked after completion. Each RCT’s detailed sham/placebo acupuncture treatment protocol was assessed according to the SHam Acupuncture REporting guidelines. The revised Cochrane risk-of-bias tool for randomized trials and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system were used to determine the risk of bias and quality of evidence, respectively. Body mass index (BMI) was defined as the primary outcome. Anthropometric parameters and laboratory test parameters related to obesity were defined as secondary outcomes. We used standardized mean difference (SMD) with 95% confidence interval (CI) to calculate treatment effects of outcomes.

Results

Fifteen RCTs with a total of 1250 patients were included. The BMI significantly decreased after treatment in the sham acupuncture group compared to baseline (SMD 0.37, 95% CI 0.09–0.66; I² = 81%, random model; P < 0.01). Treatment duration (P = 0.02) and other interventions significantly impacted the placebo response rate (P = 0.00).

Conclusion

The placebo response of sham acupuncture was strong in the RCTs for simple obesity, and the effect sizes differed between various outcomes. The treatment duration and other interventions emerged as potential influencing factors for the placebo response of sham acupuncture.

Please cite this article as: Liu KJ, Jiao RM, Ji J, Yao WW, Han CR, Zhao XY, Zhao JJ. Placebo response in sham acupuncture therapy trials for simple obesity: a systematic review and meta-analysis. J Integr Med. 2025; 23(3): 264–273.

背景：针灸对单纯性肥胖患者有潜在的治疗效果。然而，一些研究人员认为，针灸的一些有效性可能是由于安慰剂反应。目的：为了解针灸治疗单纯性肥胖患者的安慰剂效应，对假针灸治疗前后进行系统评价和meta分析。检索策略：检索自成立至2023年8月1日的8个数据库（PubMed、Web of Science、Cochrane Library、Embase、中国国家知识基础设施、万方数据库、中国生物医学数据库、中国科学期刊库）。MeSH搜索词包括肥胖和针灸。纳入标准：随机对照试验（rct）采用假针灸或安慰剂针灸作为治疗肥胖的对照。数据提取与分析：两位研究者独立提取数据，完成后对结果进行交叉核对。每个RCT的详细假/安慰剂针灸治疗方案根据假针灸报告指南进行评估。修订后的Cochrane随机试验偏倚风险工具和分级推荐评估、发展和评价（GRADE）系统分别用于确定偏倚风险和证据质量。身体质量指数（BMI）被定义为主要终点。与肥胖相关的人体测量参数和实验室测试参数被定义为次要结局。我们使用95%可信区间（CI）的标准化平均差（SMD）来计算结果的治疗效果。结果：纳入15项随机对照试验，共1250例患者。与基线相比，假针组治疗后BMI显著降低(SMD 0.37, 95% CI 0.09-0.66；I2 = 81%，随机模型；结论：在单纯性肥胖的随机对照试验中，假针灸的安慰剂效应较强，且不同结局间的效应量存在差异。治疗时间和其他干预措施是影响假针灸安慰剂反应的潜在因素。本文署名：刘建军，焦荣，季军，姚文文，韩荣，赵学勇，赵建军。单纯性肥胖的假针灸治疗试验中的安慰剂反应：系统回顾和荟萃分析。集成医学[J]；打印前Epub。

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引用次数: 0

Potential of Cinnamomum zeylanicum for metabolic syndrome management: insights from in vivo and human studies 肉桂治疗代谢综合征的潜力：来自体内和人体研究的见解。

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2025-05-01 DOI: 10.1016/j.joim.2025.04.005

Saikrupa Adarthaiya , Vishnu Kirthi Arivarasan

Metabolic syndrome (MetS) is a cluster of risk factors that significantly increase the chances of developing heart disease, type 2 diabetes mellitus, stroke, and other cardiovascular complications. Since current anti-MetS medications like statins, angiotensin-converting enzyme inhibitors, β-blockers, insulin sensitizers and diuretics have been reported to cause unwanted side effects, researchers are exploring promising alternatives. One such alternative relies on the potential of spices and condiments, which have a long history of use in traditional medicine. Among them, Cinnamomum zeylanicum Blume stands out as a popular spice worldwide for its unique taste, aroma, and delicate sweetness compared to other cinnamon varieties. This narrative review aims to summarize the in vivo and clinical evidence concerning the efficacy of C. zeylanicum against MetS indices. Relevant articles from PubMed, Scopus and Google scholar databases were reviewed. In vivo results suggested that C. zeylanicum preparations (extracts, essential oil, crude powder, bioactive compounds, and biosynthesized nanoparticles) were remarkably efficient in ameliorating MetS indices, while the clinical data were less and with several methodological limitations. Further robust clinical studies are warranted to definitively establish C. zeylanicum as a promising functional food for mitigating MetS, potentially leading to its dietary integration as a natural approach to improve metabolic health.

Please cite this article as: Adarthaiya S, Arivarasan VK. Potential of Cinnamomum zeylanicum for metabolic syndrome management: insights from in vivo and human studies. J Integr Med. 2025; 23(3): 218–229.

代谢综合征（MetS）是一组显著增加患心脏病、2型糖尿病、中风和其他心血管并发症几率的危险因素。由于目前的抗代谢代谢药物，如他汀类药物、血管紧张素转换酶抑制剂、β受体阻滞剂、胰岛素增敏剂和利尿剂，据报道会引起不必要的副作用，研究人员正在探索有希望的替代品。其中一种替代方案依赖于香料和调味品的潜力，它们在传统医学中有着悠久的使用历史。其中，肉桂（Cinnamomum zeylanicum Blume）以其独特的口感、香气和细腻的甜味，与其他肉桂品种相比，成为全球流行的香料。本文综述了zeylanicum对MetS指标的体内和临床疗效。检索PubMed、Scopus和谷歌学者数据库的相关文章。体内实验结果表明，莪术制剂（提取物、精油、粗粉、生物活性化合物和生物合成纳米颗粒）对改善MetS指数有显著的效果，但临床数据较少，并且存在一些方法学上的局限性。进一步强有力的临床研究有必要明确地确定C. zeylanicum作为一种有前景的功能食品，以减轻MetS，可能导致其饮食整合作为一种自然的方法来改善代谢健康。这篇文章请注明出处：Adarthaiya S， Arivarasan VK。肉桂治疗代谢综合征的潜力：来自体内和人体研究的见解。集成医学[J]；打印前Epub。

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引用次数: 0

Current situation of clinical trial registration in acupuncture anesthesia: A scoping review 针刺麻醉临床试验注册的现状：范围综述。

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2025-05-01 DOI: 10.1016/j.joim.2025.03.003

Yue Li , You-ning Liu , Zhen Guo , Mu-en Gu , Wen-jia Wang , Yi Zhu , Xiao-jun Zhuang , Li-ming Chen , Jia Zhou , Jing Li

Background

Modern acupuncture anesthesia is a combination of Chinese and Western medicine that integrates the theories of acupuncture with anesthesia. However, some clinical studies of acupuncture anesthesia lack specific descriptions of randomization, allocation concealment, and blinding processes, with subsequent systematic reviews indicating a risk of bias.

Objective

Clinical trial registration is essential for the enhancement of the quality of clinical trials. This study aims to summarize the status of clinical trial registrations for acupuncture anesthesia listed on the World Health Organization International Clinical Trials Registry Platform (ICTRP).

Search strategy

We searched the ICTRP for clinical trials related to acupuncture anesthesia registered between January 1, 2001 and May 31, 2023. Additionally, related publications were retrieved from PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Data. Registrations and publications were analyzed for consistency in trial design characteristics.

Inclusion criteria

Clinical trials that utilized one of several acupuncture-related therapies in combination with pharmacological anesthesia during the perioperative period were eligible for this review.

Data extraction and analysis

Data extracted from articles included type of surgical procedure, perioperative symptoms, study methodology, type of intervention, trial recruitment information, and publication information related to clinical enrollment.

Results

A total of 166 trials related to acupuncture anesthesia from 21 countries were included in the analysis. The commonly reported symptoms in the included studies were postoperative nausea and vomiting (19.9%) and postoperative pain (13.3%). The concordance between the publications and the trial protocols in the clinical registry records was poor, with only 31.7% of the studies being fully compatible. Inconsistency rates were high for sample size (39.0%, 16/41), blinding (36.6%, 15/41), and secondary outcome indicators (24.4%, 10/41).

Conclusion

The volume of acupuncture anesthesia clinical trials registered in international trial registries over the last 20 years is low, with insufficient disclosure of results. Postoperative nausea and vomiting as well as postoperative pain, are the most investigated for acupuncture intervention.

Please cite this article as: Li Y, Liu YN, Guo Z, Gu ME, Wang WJ, Zhu Y, Zhuang XJ, Chen LM, Zhou J, Li J. Current situation of clinical trial registration in acupuncture anesthesia: A scoping review. J Integr Med. 2025; 23(3): 256–263.

背景：现代针刺麻醉是将针刺理论与麻醉理论相结合的中西医结合。然而，一些针刺麻醉的临床研究缺乏对随机化、分配隐藏和盲法过程的具体描述，随后的系统评价表明存在偏倚风险。目的：临床试验注册对提高临床试验质量至关重要。本研究旨在总结世界卫生组织国际临床试验注册平台（ICTRP）上针灸麻醉临床试验注册的现状。检索策略：我们检索了ICTRP中2001年1月1日至2023年5月31日注册的与针灸麻醉相关的临床试验。检索PubMed、Cochrane图书馆、Embase、中国国家知识基础设施、中国科技期刊数据库和万方数据。对注册资料和出版物进行一致性分析。纳入标准：围手术期使用几种针灸相关疗法中的一种与药物麻醉相结合的临床试验符合本综述的要求。资料提取与分析：从文献中提取的资料包括手术类型、围手术期症状、研究方法、干预措施类型、试验招募信息以及与临床入组相关的出版物信息。结果：来自21个国家的166项与针刺麻醉相关的试验被纳入分析。纳入的研究中常见的症状是术后恶心和呕吐（19.9%）和术后疼痛（13.3%）。临床注册记录中出版物与试验方案之间的一致性很差，只有31.7%的研究完全兼容。样本量（39.0%,16/41）、盲法（36.6%,15/41）和次要结局指标（24.4%,10/41）的不一致率较高。结论：近20年来在国际试验注册中心注册的针灸麻醉临床试验数量较少，结果披露不足。术后恶心和呕吐以及术后疼痛是针刺干预研究最多的。本文编号：李勇，刘勇，郭忠，顾梅，王文杰，朱勇，庄晓军，陈立明，周军，李军。针刺麻醉临床试验注册现状：一项范围综述。集成医学[J]；打印前Epub。

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引用次数: 0

Balancing tradition and conservation: Exploring plant part substitution in traditional medicine 平衡传统与保护：探索传统医学中植物部分的替代。

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2025-05-01 DOI: 10.1016/j.joim.2025.04.001

Bhavana Srivastava , Himanshu Sharma , Ajay Kumar Meena , Vandana Bharthi

Traditional medicine, deeply rooted in cultural practices and historical wisdom, has faced surging challenges due to the escalating demand for plant-based remedies. This comprehensive review critically emphasizes the urgent need for sustainable practices within traditional medicine, with a special focus on the potential of plant part substitution. Case studies that illuminate successful instances of substituting plant parts and providing a deep insight into viable alternatives to conventional practices are presented. Opportunities and challenges inherent in plant part substitution are discussed by addressing key considerations such as phytochemical and pharmacological aspects, safety and toxicity profiles, cultural insights, standardization, clinical validation, and regulatory compliance. This review serves as a guide for navigating the delicate balance between tradition and conservation within indigenous medicine practices. It underscores the importance of embracing sustainable approaches through plant part substitution, ensuring the preservation of cultural heritage while meeting the evolving healthcare needs of society.

Please cite this article as: Srivastava B, Sharma H, Meena AK, Bharthi V. Balancing tradition and conservation: exploring plant part substitution in traditional medicine. J Integr Med. 2025; 23(3): 209–217.

传统医学深深植根于文化习俗和历史智慧，由于对植物疗法的需求不断增加，传统医学面临着日益严峻的挑战。这篇全面的综述批判性地强调了传统医学中可持续实践的迫切需要，特别关注植物部分替代的潜力。案例研究阐明了替代植物部件的成功实例，并提供了对传统做法的可行替代方案的深刻见解。通过解决关键因素，如植物化学和药理学方面、安全性和毒性概况、文化见解、标准化、临床验证和法规遵从性，讨论了植物部分替代所固有的机遇和挑战。这篇综述为在土著医学实践中实现传统与保护之间的微妙平衡提供了指南。它强调了通过植物部分替代采用可持续方法的重要性，确保保护文化遗产，同时满足社会不断变化的医疗保健需求。请引用本文：Srivastava B， Sharma H, Meena AK, Bharthi V.平衡传统与保护：探索传统医学中的植物部分替代。集成医学[J]；打印前Epub。

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引用次数: 0

Xuebijing injection reduces COVID-19 patients’ mortality as influenced by the neutrophil to lymphocyte platelet ratio 血必净注射液受中性粒细胞与淋巴细胞血小板比值的影响可降低COVID-19患者的死亡率。

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2025-05-01 DOI: 10.1016/j.joim.2025.04.002

Man Liao , Li-ting Zhang , Li-juan Bai, Rui-yun Wang, Yun Liu, Jing Han, Li-hua Liu, Ben-ling Qi

Objective

Xuebijing injection has been recommended as a therapeutic approach for individuals with severe and critical COVID-19. This study aims to explore the correlation of neutrophil to lymphocyte platelet ratio (NLPR) with the severity and prognosis of COVID-19, and the effect of XBJ on the prognosis of patients with COVID-19 in different inflammatory states.

Methods

This was a retrospective study conducted at Wuhan Union Hospital in China. COVID-19 patients admitted between November 1, 2022 and February 1, 2023 were included. In predicting prognosis for individuals with COVID-19, new inflammatory indicators were used, and their prognostic value was assessed by using Cox regression models and receiver operating characteristic curves. Furthermore, a calculation was made to determine the cutoff value for NLPR. Relative risk and Cox regression models were used to examine the effects of Xuebijing injection on prognosis in patient cohorts that had been stratified by the NLPR cutoff.

Results

This research included 455 participants with COVID-19, with a mean age of 72 years. Several inflammatory indicators were found to be strongly correlated with prognosis, and NLPR shows the greatest predictive power. Patients with NLPR > 3.29 exhibited a mortality rate of 17.3%, which was 6.2 times higher than in patients with NLPR ≤ 3.29. Importantly, providing Xuebijing injection to patients with NLPR > 3.29 was associated with a lower risk of 60-day all-cause mortality. However, there was no discernible improvement in survival among patients with NLPR ≤ 3.29 who received Xuebijing injection.

Conclusion

NLPR is the most reliable inflammatory marker for predicting prognosis among individuals with COVID-19, and can accurately identify individuals who may benefit from Xuebijing injection.

Please cite this article as: Liao M, Zhang LT, Bai LJ, Wang RY, Liu Y, Han J, Liu LH, Qi BL. Xuebijing injection reduces COVID-19 patients mortality as influenced by the neutrophil to lymphocyte platelet ratio. J Integr Med. 2025; 23(3): 282–288.

目的：血必净注射液已被推荐作为治疗COVID-19重型和危重型患者的方法。本研究旨在探讨中性粒细胞与淋巴细胞血小板比值（NLPR）与COVID-19严重程度及预后的相关性，以及XBJ对不同炎症状态下COVID-19患者预后的影响。方法：本研究是在中国武汉协和医院进行的回顾性研究。纳入了2022年11月1日至2023年2月1日期间入院的COVID-19患者。在预测COVID-19患者预后时，采用新的炎症指标，并通过Cox回归模型和受试者工作特征曲线评估其预后价值。此外，还计算了NLPR的临界值。采用相对风险模型和Cox回归模型检验血必净注射液对NLPR截止分层患者队列预后的影响。结果：本研究纳入了455名COVID-19患者，平均年龄72岁。多个炎症指标与预后密切相关，其中NLPR预测能力最强。NLPR≤3.29患者的死亡率为17.3%，是NLPR≤3.29患者的6.2倍。重要的是，向NLPR患者提供血必净注射液与60天全因死亡率降低相关。然而，在NLPR≤3.29的患者中，接受血必净注射液的患者生存率无明显改善。结论：NLPR是预测COVID-19患者预后最可靠的炎症标志物，可准确识别可能受益于血必净注射液的个体。廖敏，张丽娟，白丽娟，王瑞瑞，刘燕，韩娟，刘丽莲，齐宝玲。血必净注射液降低新冠肺炎患者中性粒细胞/淋巴细胞血小板比例的影响。集成医学[J]；打印前Epub。

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引用次数: 0

Early improvement to electroacupuncture at week 3 predicts ultimate response in patients with chronic severe functional constipation 电针治疗第3周早期改善可预测慢性严重功能性便秘患者的最终疗效。

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2025-05-01 DOI: 10.1016/j.joim.2025.04.004

Zhi-yi Xiong , Shi-yan Yan , Si-xing Liu , Zhi-shun Liu

Objective

To investigate whether the presence or absence of improvement in chronic severe functional constipation (CSFC) at the early stage of treatment with electroacupuncture predicts subsequent response or non-response, and to determine the optimal treatment duration for assessing subsequent responses to electroacupuncture.

Methods

This is a post hoc analysis using data pooled from two large-scale randomized controlled trials. Patients with CSFC were recruited, and those in the electroacupuncture groups were included in the present study. Early improvement was defined as a weekly increase of ≥1 complete spontaneous bowel movement (CSBM) compared to baseline. Three treatment response criteria were evaluated: ≥ 3 CSBMs per week, overall CSBM response, and sustained CSBM response. Predictive statistics, including sensitivity, specificity, positive predictive value, and negative predictive value, were calculated at weeks 1–4. Receiver operating characteristic curves and accuracy rates were used to determine the optimal timepoint for differentiation between responders and non-responders.

Results

Cases from a total of 813 participants who received electroacupuncture were analyzed. The proportion of improvers was 40.34% by week 1, increasing to 52.52% by week 4. After 8 weeks of treatment, the response rates were 30.14%, 25.83% and 25.58% according to the three aforementioned criteria, respectively. Early improvement was a strong predictor of treatment response, with week 3 demonstrating the highest predictive accuracy.

Conclusion

Early improvement with electroacupuncture, especially at week 3, can predict subsequent outcomes. Our findings suggest that acupuncturists may identify non-responders who might require adjustments to therapeutic strategies early in treatment.

Please cite this article as: Xiong ZY, Yan SY, Liu SX, Liu ZS. Early improvement to electroacupuncture at week 3 predicts ultimate response in patients with chronic severe functional constipation. J Integr Med. 2025; 23(3): 274–281.

目的：探讨电针治疗早期慢性重度功能性便秘（CSFC）的改善是否能预测随后的反应或无反应，并确定评估电针后续反应的最佳治疗时间。方法：采用两项大规模随机对照试验的数据进行事后分析。我们招募了CSFC患者，电针组的患者也被纳入本研究。早期改善定义为与基线相比每周增加≥1次完全自发排便（CSBM）。评估三个治疗反应标准：每周≥3次CSBM，总体CSBM反应和持续CSBM反应。在第1-4周计算预测统计，包括敏感性、特异性、阳性预测值和阴性预测值。使用受试者工作特征曲线和准确率来确定区分应答者和无应答者的最佳时间点。结果：共分析了813例接受电针治疗的患者的病例。第1周改善者比例为40.34%，第4周改善者比例为52.52%。治疗8周后，根据上述三个标准，有效率分别为30.14%、25.83%和25.58%。早期改善是治疗反应的有力预测指标，第3周的预测准确性最高。结论：电针治疗的早期改善，特别是在第3周，可以预测随后的结果。我们的研究结果表明，针灸师可以在治疗早期识别出可能需要调整治疗策略的无反应者。这篇文章的题名是：熊志强，严思义，刘思祥，刘志生。电针治疗第3周早期改善可预测慢性严重功能性便秘患者的最终疗效。集成医学[J]；打印前Epub。

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引用次数: 0

Morin inhibits ubiquitination degradation of BCL-2 associated agonist of cell death and synergizes with BCL-2 inhibitor in gastric cancer cells Morin抑制胃癌细胞中BCL-2相关细胞死亡激动剂的泛素化降解并与BCL-2抑制剂协同作用。

IF 4.2 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2025-05-01 DOI: 10.1016/j.joim.2025.04.006

Yi Wang , Xiao-yu Sun , Fang-qi Ma , Ming-ming Ren , Ruo-han Zhao , Meng-meng Qin , Xiao-hong Zhu , Yan Xu , Ni-da Cao , Yuan-yuan Chen , Tian-geng Dong , Yong-fu Pan , Ai-guang Zhao

Objective

Gastric cancer (GC) is one of the most common malignancies seen in clinic and requires novel treatment options. Morin is a natural flavonoid extracted from the flower stalk of a highly valuable medicinal plant Prunella vulgaris L., which exhibits an anti-cancer effect in multiple types of tumors. However, the therapeutic effect and underlying mechanism of morin in treating GC remains elusive. The study aims to explore the therapeutic effect and underlying molecular mechanisms of morin in GC.

Methods

For in vitro experiments, the proliferation inhibition of morin was measured by cell counting kit-8 assay and colony formation assay in human GC cell line MKN45, human gastric adenocarcinoma cell line AGS, and human gastric epithelial cell line GES-1; for apoptosis analysis, microscopic photography, Western blotting, ubiquitination analysis, quantitative polymerase chain reaction analysis, flow cytometry, and RNA interference technology were employed. For in vivo studies, immunohistochemistry, biomedical analysis, and Western blotting were used to assess the efficacy and safety of morin in a xenograft mouse model of GC.

Results

Morin significantly inhibited the proliferation of GC cells MKN45 and AGS in a dose- and time-dependent manner, but did not inhibit human gastric epithelial cells GES-1. Only the caspase inhibitor Z-VAD-FMK was able to significantly reverse the inhibition of proliferation by morin in both GC cells, suggesting that apoptosis was the main type of cell death during the treatment. Morin induced intrinsic apoptosis in a dose-dependent manner in GC cells, which mainly relied on B cell leukemia/lymphoma 2 (BCL-2) associated agonist of cell death (BAD) but not phorbol-12-myristate-13-acetate-induced protein 1. The upregulation of BAD by morin was due to blocking the ubiquitination degradation of BAD, rather than the transcription regulation and the phosphorylation of BAD. Furthermore, the combination of morin and BCL-2 inhibitor navitoclax (also known as ABT-737) produced a synergistic inhibitory effect in GC cells through amplifying apoptotic signals. In addition, morin treatment significantly suppressed the growth of GC in vivo by upregulating BAD and the subsequent activation of its downstream apoptosis pathway.

Conclusion

Morin suppressed GC by inducing apoptosis, which was mainly due to blocking the ubiquitination-based degradation of the pro-apoptotic protein BAD. The combination of morin and the BCL-2 inhibitor ABT-737 synergistically amplified apoptotic signals in GC cells, which may overcome the drug resistance of the BCL-2 inhibitor. These findings indicated that morin was a potent and promising agent for GC treatment.

Please cite this article as: Wang Y, Sun XY, Ma FQ, Ren MM, Zhao RH, Qin MM, Zhu XH, Xu Y, Cao ND, Chen YY, Dong TG, Pan YF, Zhao AG. Morin inhibits ubiquitination degradation of

目的：胃癌（GC）是临床上最常见的恶性肿瘤之一，需要新的治疗方案。桑里素是从药用植物Prunella vulgaris L.的花茎中提取的一种天然类黄酮，对多种肿瘤均有抗癌作用。然而，桑辣素治疗胃癌的疗效和机制尚不清楚。本研究旨在探讨桑苷对胃癌的治疗作用及其分子机制。方法：采用细胞计数试剂盒-8法和集落形成法对人胃癌细胞系MKN45、人胃腺癌细胞系AGS和人胃上皮细胞系GES-1进行体外增殖抑制实验；细胞凋亡分析采用显微摄影、Western blotting、泛素化分析、定量聚合酶链反应分析、流式细胞术和RNA干扰技术。在体内研究中，采用免疫组织化学、生物医学分析和Western blotting来评估桑里酯对异种移植小鼠GC模型的有效性和安全性。结果：桑辣素显著抑制胃癌细胞MKN45和AGS的增殖，且呈剂量和时间依赖性，但对人胃上皮细胞GES-1无抑制作用。在两种GC细胞中，只有caspase抑制剂Z-VAD-FMK能够显著逆转桑肽对细胞增殖的抑制作用，提示凋亡是治疗过程中细胞死亡的主要类型。桑辣素以剂量依赖性方式诱导GC细胞内在凋亡，主要依赖于B细胞白血病/淋巴瘤2 （BCL-2）相关的细胞死亡激动剂（BAD），而不依赖于phorpol -12-肉豆酸盐-13-乙酸盐诱导的蛋白1。桑辣素对BAD的上调是由于阻断BAD的泛素化降解，而不是由于对BAD的转录调控和磷酸化。此外，morin与BCL-2抑制剂navitoclax（也称为ABT-737）联合使用，通过放大凋亡信号，对GC细胞产生协同抑制作用。此外，桑皮素处理通过上调BAD并激活其下游凋亡通路，显著抑制体内GC的生长。结论：桑辣素对GC的抑制作用主要是通过抑制促凋亡蛋白BAD的泛素化降解。桑苷与BCL-2抑制剂ABT-737联用可协同放大胃癌细胞的凋亡信号，可能克服BCL-2抑制剂的耐药。这些结果表明，桑皮素是一种有效的、有前途的气相色谱治疗剂。本文署名：王毅，孙学勇，马方强，任敏，赵荣荣，秦敏，朱晓华，徐毅，曹德宁，陈奕云，董国涛，潘云峰，赵爱岗。Morin抑制胃癌细胞中BCL-2相关细胞死亡激动剂的泛素化降解并与BCL-2抑制剂协同作用。集成医学[J]；打印前Epub。

{"title":"Morin inhibits ubiquitination degradation of BCL-2 associated agonist of cell death and synergizes with BCL-2 inhibitor in gastric cancer cells","authors":"Yi Wang , Xiao-yu Sun , Fang-qi Ma , Ming-ming Ren , Ruo-han Zhao , Meng-meng Qin , Xiao-hong Zhu , Yan Xu , Ni-da Cao , Yuan-yuan Chen , Tian-geng Dong , Yong-fu Pan , Ai-guang Zhao","doi":"10.1016/j.joim.2025.04.006","DOIUrl":"10.1016/j.joim.2025.04.006","url":null,"abstract":"<div><h3>Objective</h3><div>Gastric cancer (GC) is one of the most common malignancies seen in clinic and requires novel treatment options. Morin is a natural flavonoid extracted from the flower stalk of a highly valuable medicinal plant <em>Prunella vulgaris</em> L., which exhibits an anti-cancer effect in multiple types of tumors. However, the therapeutic effect and underlying mechanism of morin in treating GC remains elusive. The study aims to explore the therapeutic effect and underlying molecular mechanisms of morin in GC.</div></div><div><h3>Methods</h3><div>For in vitro experiments, the proliferation inhibition of morin was measured by cell counting kit-8 assay and colony formation assay in human GC cell line MKN45, human gastric adenocarcinoma cell line AGS, and human gastric epithelial cell line GES-1; for apoptosis analysis, microscopic photography, Western blotting, ubiquitination analysis, quantitative polymerase chain reaction analysis, flow cytometry, and RNA interference technology were employed. For in vivo studies, immunohistochemistry, biomedical analysis, and Western blotting were used to assess the efficacy and safety of morin in a xenograft mouse model of GC.</div></div><div><h3>Results</h3><div>Morin significantly inhibited the proliferation of GC cells MKN45 and AGS in a dose- and time-dependent manner, but did not inhibit human gastric epithelial cells GES-1. Only the caspase inhibitor Z-VAD-FMK was able to significantly reverse the inhibition of proliferation by morin in both GC cells, suggesting that apoptosis was the main type of cell death during the treatment. Morin induced intrinsic apoptosis in a dose-dependent manner in GC cells, which mainly relied on B cell leukemia/lymphoma 2 (BCL-2) associated agonist of cell death (BAD) but not phorbol-12-myristate-13-acetate-induced protein 1. The upregulation of BAD by morin was due to blocking the ubiquitination degradation of BAD, rather than the transcription regulation and the phosphorylation of BAD. Furthermore, the combination of morin and BCL-2 inhibitor navitoclax (also known as ABT-737) produced a synergistic inhibitory effect in GC cells through amplifying apoptotic signals. In addition, morin treatment significantly suppressed the growth of GC in vivo by upregulating BAD and the subsequent activation of its downstream apoptosis pathway.</div></div><div><h3>Conclusion</h3><div>Morin suppressed GC by inducing apoptosis, which was mainly due to blocking the ubiquitination-based degradation of the pro-apoptotic protein BAD. The combination of morin and the BCL-2 inhibitor ABT-737 synergistically amplified apoptotic signals in GC cells, which may overcome the drug resistance of the BCL-2 inhibitor. These findings indicated that morin was a potent and promising agent for GC treatment.</div><div>Please cite this article as: Wang Y, Sun XY, Ma FQ, Ren MM, Zhao RH, Qin MM, Zhu XH, Xu Y, Cao ND, Chen YY, Dong TG, Pan YF, Zhao AG. Morin inhibits ubiquitination degradation of","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"23 3","pages":"Pages 320-332"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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