Journal of Integrative Medicine-Jim最新文献_第7页

Efficacy of acupuncture on cancer pain: A systematic review and meta-analysis 针灸对癌症疼痛的疗效：系统回顾与荟萃分析

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2024-05-01 DOI: 10.1016/j.joim.2024.03.002

Miguel Faria , Mónica Teixeira , Maria João Pinto , Paulo Sargento

Background

Pain associated with cancer is one of the greatest causes of reduced quality of life in patients. Acupuncture is one of the treatments used to address this issue, with the great advantage of having little or no side effects, especially when compared with pharmacological pain-killers.

Objective

The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer pain.

Search strategy

Six electronic databases (PubMed, EBSCO, Cochrane Library, Scielo, b-On and Scopus) were searched for relevant articles about pain relief in cancer patients from their beginning until 2022 using MeSH terms such as “acupuncture,” “electroacupuncture,” “ear acupuncture,” “acupuncture analgesia,” ‘‘oncological pain,” and “cancer pain.”

Inclusion criteria

Studies included were randomized controlled trials (RCTs) where acupuncture was compared with no treatment, placebo acupuncture or usual care.

Data extraction and analysis

Three independent reviewers participated in data extraction and evaluation of risk of bias, and a meta-analysis was conducted. The primary outcome was pain intensity, measured with the visual analog scale, numeric rating scale, or brief pain inventory. Secondary outcomes also assessed were quality of life, functionality, xerostomia, pain interference, and analgesic consumption. Results were expressed as standardized mean difference (SMD) with 95% confidence interval (CI).

Results

Sixteen RCTs with a total of 1124 participants were included in the meta-analysis, with the majority of the studies presenting a low or unclear risk of bias. Acupuncture was more effective in reducing pain than no treatment (SMD = –0.90, 95 % CI [–1.68, –0.12]), sham acupuncture (SMD = –1.10, 95 % CI [–1.59, –0.61]) or usual care (SMD = –1.16, 95 % CI [–1.38, –0.93]).

Conclusion

The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with cancer. Despite some limitations due to the low quality and small sample size of some included studies, as well as the different types and stages of cancer, acupuncture might provide an effective and safe treatment to reduce cancer pain.

Please cite this article as: Faria M, Teixeira M, Pinto MJ, Sargento P. Efficacy of acupuncture on cancer pain: A systematic review and meta-analysis. J Integr Med. 2024; 22(3): 235–244.

与癌症相关的疼痛是导致患者生活质量下降的最大原因之一。针灸是解决这一问题的治疗方法之一，其最大的优点是几乎没有副作用，尤其是与药物止痛药相比。本系统综述和荟萃分析旨在评估针灸治疗癌症疼痛疗效的现有证据。荟萃分析纳入了 16 项研究，共有 1124 人参与，其中大部分研究的偏倚风险较低或不明确。与不治疗（SMD = -0.90，95% CI [-1.68，-0.12]）、假针灸（SMD =-1.10，95% CI [-1.59，-0.61]）或常规护理（SMD =-1.16，95% CI [-1.38，-0.93]）相比，针灸能更有效地减轻疼痛。这项研究结果表明，针灸可能是减少癌症相关疼痛的有效干预措施。尽管由于部分纳入研究的质量较低和样本量较小，以及癌症的不同类型和阶段而存在一些局限性，但针灸可能是一种有效且安全的减轻癌症疼痛的治疗方法。

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引用次数: 0

Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses 治疗缺血性中风的中药银杏叶制剂：系统回顾和荟萃分析综述

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2024-03-01 DOI: 10.1016/j.joim.2024.03.003

Tian-tian Meng , Ya-ping You , Min Li , Jian-bo Guo , Xin-bin Song , Jing-yi Ding , Xiao-long Xie , An-qi Li , Shang-jin Li , Xiang-jun Yin , Peng Wang , Zhe Wang , Bao-liang Wang , Qing-yong He

Background

Ginkgo biloba L. preparations (GBLPs) are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke (IS). Recently, several systematic reviews (SRs) and meta-analyses (MAs) of GBLPs for IS have been published.

Objective

This overview aims to assess the quality of related SRs and MAs.

Search strategy

PubMed, Embase, Cochrane Library, Web of Science, Chinese Biological Medicine, China National Knowledge Infrastructure, Wanfang, and Chinese Science and Technology Journals databases were searched from their inception to December 31, 2022.

Inclusion criteria

SRs and MAs of randomized controlled trials (RCTs) that explored the efficacy of GBLPs for patients with IS were included.

Data extraction and analysis

Two independent reviewers extracted data and assessed the methodological quality, risk of bias (ROB), reporting quality, and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2), Risk of Bias in Systematic Reviews (ROBIS), the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), and the Grading of Recommendations Assessment, Development and Evaluation (GRADE), respectively. Additionally, descriptive analysis and data synthesis were conducted.

Results

Twenty-nine SRs/MAs involving 119 outcomes were included in this review. The overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2, and 28 had a high ROB based on the ROBIS. According to the PRISMA statement, the reporting items of the included SRs/MAs are relatively complete. The results based on GRADE showed that of the 119 outcomes, 8 were rated as moderate quality, 24 as low quality, and 87 as very low quality. Based on the data synthesis, GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function scores.

Conclusion

GBLPs can be considered a beneficial supplemental therapy for IS. However, because of the low quality of the existing evidence, high-quality RCTs and SRs/MAs are warranted to further evaluate the benefits of GBLPs for treating IS.

Please cite this article as: Meng TT, You YP, Li M, Guo JB, Song XB, Ding JY, Xie XL, Li AQ, Li SJ, Yin XJ, Wang P, Wang Z, Wang BL, He QY. Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses. J Integr Med. 2024;22(2): 163–179.

国标中药制剂（GBLPs）是一类用于缺血性中风（IS）辅助治疗的中药。最近，发表了多篇关于GBLPs治疗缺血性中风的系统综述（SR）和荟萃分析（MA）。本综述旨在评估相关 SR 和 MA 的质量。本综述共纳入了29篇SR/MA，涉及119项结果。根据AMSTAR 2，所有SR/MA的总体方法学质量为极低，根据ROBIS，28项为高ROB。根据 PRISMA 声明，纳入的 SR/MA 的报告项目相对完整。基于 GRADE 的结果显示，在 119 项结果中，8 项被评为中等质量，24 项为低质量，87 项为极低质量。根据数据综合，在降低神经功能评分方面，GBLPs 与常规治疗联合使用优于单独使用常规治疗。GBLPs可被视为IS的有益补充疗法。然而，由于现有证据的质量较低，因此需要进行高质量的 RCT 和 SR/MA，以进一步评估 GBLPs 对治疗 IS 的益处。

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引用次数: 0

Chrononutrition in traditional European medicine—Ideal meal timing for cardiometabolic health promotion 欧洲传统医学中的慢性营养--促进心脏代谢健康的理想进餐时间。

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2024-03-01 DOI: 10.1016/j.joim.2024.02.002

Nora Selena Eberli, Ludivine Colas, Anne Gimalac

Meal timing plays a crucial role for cardiometabolic health, given the circadian regulation of cardiometabolic function. However, to the best of our knowledge, no concept of meal timing exists in traditional European medicine (TEM). Therefore, in this narrative review, we aim to define the optimal time slot for energy intake and optimal energy distribution throughout the day in a context of TEM and explore further implications. By reviewing literature published between 2002 and 2022, we found that optimal timing for energy intake may be between 06:00 and 09:00, 12:00 and 14:00, and between 15:00 and 18:00, with high energy breakfast, medium energy lunch and low energy dinner and possibly further adjustments according to one’s chronotype and genetics. Also, timing and distribution of energy intake may serve as a novel therapeutic strategy to optimize coction, a concept describing digestion and metabolism in TEM.

Please cite this article as: Eberli NS, Colas L, Gimalac A. Chrononutrition in traditional European medicine—Ideal meal timing for cardiometabolic health promotion. J Integr Med. 2024; 22(2);115–125.

鉴于昼夜节律对心脏代谢功能的调节作用，进餐时间对心脏代谢健康起着至关重要的作用。然而，据我们所知，欧洲传统医学（TEM）中并不存在进餐时间的概念。因此，在这篇叙述性综述中，我们的目的是在 TEM 的背景下定义能量摄入的最佳时间段和全天的最佳能量分配，并探讨进一步的影响。通过回顾 2002 年至 2022 年间发表的文献，我们发现能量摄入的最佳时间段可能是 6:00 至 9:00、12:00 至 14:00、15:00 至 18:00，其中早餐能量高、午餐能量适中、晚餐能量低，并可能根据个人的时间型和遗传学做进一步调整。此外，能量摄入的时间和分布可作为一种新的治疗策略，优化TEM中的消化和新陈代谢。本文引用如前：Eberli NS, Colas L, Gimalac A. 欧洲传统医学中的慢性营养--促进心脏代谢健康的理想进餐时间。J Integr Med.2024; Epub ahead of print.

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引用次数: 0

Acupuncture for obesity and related diseases: Insight for regulating neural circuit 针灸治疗肥胖症及相关疾病：调节神经回路的启示

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2024-03-01 DOI: 10.1016/j.joim.2024.03.001

Lin-yan Jiang , Jun Tian , Ya-nan Yang , Shao-hui Jia , Qing Shu

Obesity is defined as abnormal or excessive fat accumulation that may impair health. Obesity is associated with numerous pathological changes including insulin resistance, fatty liver, hyperlipidemias, and other obesity-related diseases. These comorbidities comprise a significant public health threat. Existing anti-obesity drugs have been limited by side effects that include depression, suicidal thoughts, cardiovascular complications and stroke. Acupuncture treatment has been shown to be effective for treating obesity and obesity-related conditions, while avoiding side effects. However, the mechanisms of acupuncture in treating obesity-related diseases, especially its effect on neural circuits, are not well understood. A growing body of research has studied acupuncture’s effects on the endocrine system and other mechanisms related to the regulation of neural circuits. In this article, recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system, as well as some neural circuits involved, was summarized. Based on this, acupuncture’s potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed, leading to a deeper mechanistic understanding of acupuncture’s effects and providing insight and direction for future research about obesity.

Please cite this article as: Jiang LY, Tian J, Yang YN, Jia SH, Shu Q. Acupuncture for obesity and related diseases: insight for regulating neural circuit. J Integr Med. 2024; 22(2): 93–101.

肥胖被定义为可能损害健康的异常或过度脂肪堆积。肥胖与许多病理变化有关，包括胰岛素抵抗、脂肪肝、高脂血症和其他肥胖相关疾病。这些并发症对公共健康构成了重大威胁。现有的抗肥胖药物受到副作用的限制，包括抑郁、自杀念头、心血管并发症和中风。针灸治疗已被证明可有效治疗肥胖症和肥胖相关疾病，同时避免副作用。然而，人们对针灸治疗肥胖相关疾病的机制，尤其是针灸对神经回路的影响还不甚了解。越来越多的研究对针灸对内分泌系统的影响以及其他与神经回路调节相关的机制进行了研究。本文总结了针灸通过神经内分泌系统治疗肥胖和肥胖相关疾病的最新研究，以及一些相关的神经回路。在此基础上，综述了针灸调节神经回路的潜在能力及其在内分泌系统中的作用机制，从而加深了对针灸作用机制的理解，并为今后有关肥胖症的研究提供了启示和方向。

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引用次数: 0

Associations between the use of red yeast rice preparations and adverse health outcomes: An umbrella review of meta-analyses of randomized controlled trials 使用红麴制剂与不良健康后果之间的关系：随机对照试验荟萃分析综述

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2024-03-01 DOI: 10.1016/j.joim.2024.01.008

Zhen-yu Ma , Shu-ping Yang , Ying Li , Tian-tian Xu , Ya-lin Yang , Hui-yong Yang , Heng-bing Li , Le-jin Zhou , Yong Diao , Su-yun Li

<div><h3>Background</h3><p>Red yeast rice (RYR), a natural lipid-lowering agent, is widely used in clinical practice. However, the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results, and the credibility of the evidence has not been quantified.</p></div><div><h3>Objective</h3><p>This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health outcomes.</p></div><div><h3>Search strategy</h3><p>Seven literature databases were searched from inception to May 5, 2023, using medical subject headings and free-text terms (e.g., “red yeast rice,” “<em>Xuezhikang</em>,” and “<em>Zhibitai</em>”).</p></div><div><h3>Inclusion criteria</h3><p>Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this study.</p></div><div><h3>Data extraction and analysis</h3><p>Two researchers independently extracted data using a standardized data collection table; any disagreements were resolved by consulting a third researcher. Based on the participant, intervention, comparator and outcome (PICO) framework in each eligible meta-analysis, a series of unique associations between the use of RYR preparations and adverse health outcomes were determined. The associations’ effect estimates were re-evaluated using random-effect models.</p></div><div><h3>Results</h3><p>Fifteen meta-analyses, comprising 186 (164 unique) randomized controlled trials, were identified. Based on A MeaSurement Tool to Assess Systematic Reviews version 2, 3 (20%) and 12 (80%) of these meta-analyses had low and critically low confidence, respectively. A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible meta-analyses. Based on the random-effect models, 10 (16.4%) associations indicated a significant protective effect of RYR preparations against adverse health outcomes, while 5 (8.2%) indicated an increased risk of adverse health outcomes related to uric acid, alanine transaminase and aspartate transaminase levels. The other 46 (75.4%) associations showed no significant difference between the use of RYR preparations and control treatments. Regarding the credibility of the evidence, 21 (34.4%), 34 (55.7%) and 6 (9.8%) associations showed moderate, low and very low credibility, respectively.</p></div><div><h3>Conclusion</h3><p>The evidence examined in this study suggests that RYR preparations are safe; however, the credibility of the evidence was not high. Further high-quality evidence is required.</p><p>Please cite this article as: Ma ZY, Yang SP, Li Y, Xu TT, Yang YL, Yang HY, Li HB, Zhou LJ, Diao Y, Li SY. Associations between the use of red yeast rice preparations and adverse health outcomes: An umbrella review of meta-analyses of randomized controlled trials. <em>J Integr Med

背景红曲米（RYR）是一种天然降血脂药物，被广泛应用于临床实践。本研究旨在评估现有证据，并全面了解使用红酵母米制剂与各种不良健康结果之间的关联。检索策略使用医学主题词和自由文本词（如 "红酵母米"、"雪芝康 "和 "知必泰"）检索了七个文献数据库，检索期从开始到 2023 年 5 月 5 日、"纳入标准本研究纳入了调查和定量估计使用红曲制剂与不良健康后果之间相关性的元分析。数据提取和分析两名研究人员使用标准化数据收集表独立提取数据；任何分歧均通过咨询第三名研究人员来解决。根据每项符合条件的荟萃分析中的参与者、干预措施、比较者和结果（PICO）框架，确定了使用 RYR 制剂与不良健康结果之间的一系列独特关联。使用随机效应模型对这些关联的效应估计值进行了重新评估。结果确定了 15 项元分析，包括 186 项随机对照试验（164 项唯一试验）。根据系统综述评估工具（A MeaSurement Tool to Assess Systematic Reviews）第 2 版，这些荟萃分析中分别有 3 项（20%）和 12 项（80%）置信度较低和极低。从符合条件的荟萃分析中，共提取了 61 项使用 RYR 制剂与不良健康结果之间的独特关联。根据随机效应模型，10 项（16.4%）关联表明 RYR 制剂对不良健康结果具有显著的保护作用，5 项（8.2%）关联表明与尿酸、丙氨酸转氨酶和天冬氨酸转氨酶水平有关的不良健康结果的风险增加。其他 46 项（75.4%）关联显示，使用 RYR 制剂与对照治疗之间没有显著差异。关于证据的可信度，21 项（34.4%）、34 项（55.7%）和 6 项（9.8%）分别显示出中等、低和极低的可信度。本文引用如前：Ma ZY, Yang SP, Li Y, Xu TT, Yang YL, Yang HY, Li HB, Zhou LJ, Diao Y, Li SY.使用红曲米制剂与不良健康后果之间的关系：随机对照试验荟萃分析综述》。J Integr Med.2023; Epub ahead of print.

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引用次数: 0

Cordyceps as potential therapeutic agents for atherosclerosis 冬虫夏草作为动脉粥样硬化的潜在治疗药物

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2024-03-01 DOI: 10.1016/j.joim.2024.03.004

Yi Zhang , Si-jing Liu

Atherosclerosis is a leading cause of mortality and morbidity worldwide. Despite the challenges in managing atherosclerosis, researchers continue to investigate new treatments and complementary therapies. Cordyceps is a traditional Chinese medicine that has recently gained attention as a potential therapeutic agent for atherosclerosis. Numerous studies have demonstrated the effectiveness of cordyceps in treating atherosclerosis through various pharmacological actions, including anti-inflammatory and antioxidant activities, lowering cholesterol, inhibiting platelet aggregation, and modulating apoptosis or autophagy in vascular endothelial cells. Notably, the current misuse of the terms cordyceps and Ophiocordyceps sinensis has caused confusion among researchers, and complicated the current academic research on cordyceps. This review focuses on the chemical composition, pharmacological actions, and underlying mechanisms contributing to the anti-atherosclerotic effects of cordyceps and the mycelium of Ophiocordyceps spp. This review provides a resource for the research on the development of new drugs for atherosclerosis from cordyceps.

Please cite this article as: Zhang Y, Liu SJ. Cordyceps as potential therapeutic agents for atherosclerosis. J Integr Med. 2024; 22(2): 102–114.

动脉粥样硬化是全球死亡和发病的主要原因。尽管动脉粥样硬化的治疗面临挑战，但研究人员仍在继续研究新的治疗方法和辅助疗法。冬虫夏草是一种传统中药，最近作为一种潜在的动脉粥样硬化治疗药物受到关注。大量研究表明，冬虫夏草具有多种药理作用，包括抗炎和抗氧化、降低胆固醇、抑制血小板聚集、调节血管内皮细胞的凋亡或自噬等，从而有效治疗动脉粥样硬化。值得注意的是，目前对冬虫夏草和冬虫夏草这两个术语的滥用在研究人员中造成了混淆，并使目前关于冬虫夏草的学术研究变得复杂。本综述主要介绍了冬虫夏草及其菌丝体的化学成分、药理作用和抗动脉粥样硬化作用的基本机制。本综述为利用冬虫夏草开发治疗动脉粥样硬化的新药提供了研究资源。

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引用次数: 0

Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review 草药化合物是癌症精准医疗策略中很有前景的治疗剂：系统综述

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2024-03-01 DOI: 10.1016/j.joim.2024.02.001

Bizhar Ahmed Tayeb , Ikhwan Yuda Kusuma , Alaa A.M. Osman , Renáta Minorics

Background

The field of personalized medicine has gained increasing attention in cancer care, with the aim of tailoring treatment strategies to individual patients for improved outcomes. Herbal medicine, with its long-standing historical use and extensive bioactive compounds, offers a rich source of potential treatments for various diseases, including cancer.

Objective

To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer diseases. Additionally, to explore the general characteristics of the studies included in the analysis, focusing on their key features and trends.

Search strategy

A comprehensive literature search was conducted from multiple online databases, including PubMed, Scopus, Web of Science, and CINAHL-EBSCO. The search strategy was designed to identify studies related to personalized cancer medicine and herbal interventions.

Inclusion criteria

Publications pertaining to cancer research conducted through in vitro, in vivo, and clinical studies, employing natural products were included in this review.

Data extraction and analysis

Two review authors independently applied inclusion and inclusion criteria, data extraction, and assessments of methodological quality. The quality assessment and biases of the studies were evaluated based on modified Jadad scales. A detailed quantitative summary of the included studies is presented, providing a comprehensive description of their key features and findings.

Results

A total of 121 studies were included in this review for analysis. Some of them were considered as comprehensive experimental investigations both in vitro and in vivo. The majority (n = 85) of the studies included in this review were conducted in vitro, with 44 of them specifically investigating the effects of herbal medicine on animal models. Additionally, 7 articles with a combined sample size of 31,271 patients, examined the impact of herbal medicine in clinical settings.

Conclusion

Personalized medication can optimize the use of herbal medicine in cancer treatment by considering individual patient factors such as genetics, medical history, and other treatments. Additionally, active phytochemicals found in herbs have shown potential for inhibiting cancer cell growth and inducing apoptosis, making them a promising area of research in preclinical and clinical investigations.

Please cite this article as: Tayeb BA, Kusuma IY, Osman AAM, Minorics R. Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review. J Integr Med. 2024; 22(2): 137–162.

在癌症治疗领域，个性化医疗越来越受到关注，其目的是为患者量身定制治疗策略，以改善治疗效果。草药具有悠久的历史和广泛的生物活性化合物，为包括癌症在内的各种疾病提供了丰富的潜在治疗方法。概述目前将草药化合物纳入癌症精准医疗策略的相关知识和证据。此外，探讨纳入分析的研究的一般特征，重点关注其主要特点和趋势。本综述共纳入 121 项研究进行分析。其中一些研究被认为是体外和体内的综合实验研究。大部分研究（= 85）是在体外进行的，其中 44 篇专门研究了草药对动物模型的影响。此外，有 7 篇文章对草药在临床环境中的影响进行了研究，总样本量达 31,271 名患者。个性化用药可通过考虑遗传学、病史和其他治疗方法等患者个体因素，优化草药在癌症治疗中的应用。此外，草药中的活性植物化学物质已显示出抑制癌细胞生长和诱导细胞凋亡的潜力，使其成为临床前和临床研究中一个前景广阔的研究领域。

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引用次数: 0

The acceptance of traditional Chinese medicine among patients with Parkinson’s disease: A hospital survey 帕金森病患者对中医药的接受程度：一项医院调查

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2024-03-01 DOI: 10.1016/j.joim.2024.03.005

Peng Wang , Jing Hong , Zhu-qian Tang , Bi-zhen Gong , Xiao-rong Qi , Han Jiang , Bo Pan , Qi Chen

Objective

The efficacy of medications for Parkinson’s disease (PD) tend to decline over time, which has a serious impact on patients’ health and quality of life. To some extent, traditional Chinese medicine (TCM) can resolve the distressing problem of ineffective dopaminergic medication in PD patients. The purpose of this study was to investigate the attitude, acceptance, and independent predictors of TCM in PD patients admitted to the outpatient department of a tertiary hospital.

Methods

A cross-sectional study of PD patients was conducted in the outpatient department of a large tertiary hospital in Beijing from March 2022 to June 2023. A self-report questionnaire was developed to investigate PD patients’ attitudes and acceptance of TCM based on the questionnaire. Multivariate logistic regression analyses were also performed to further clarify the independent predictors influencing patients’ adoption of TCM therapy.

Results

A total of 397 patients completed the questionnaire, of which 78.09% were willing to be treated with TCM and 21.91% indicated that they were not willing to use TCM. Multifactorial logistic regression analysis showed that several parameters were correlated with a patient’s willingness to include TCM in their therapeutic regime. These included education level of a bachelor’s degree (odds ratio [OR) = 8.554; 95% confidence interval [CI]: 4.112–17.794; P < 0.001, vs junior high school education), living in an urban setting (OR = 8.022; 95% CI: 4.577–14.060; P < 0.001, vs rural), having other underlying diseases (OR = 5.126; 95% CI: 3.078–8.537; P < 0.001, vs none), having previously used TCM (OR = 3.083; 95% CI: 1.852–5.134; P < 0.001, vs not used), believing that TCM therapy is safe (OR = 3.530; 95% CI: 1.446–8.616; P = 0.006, vs not thought), believing that TCM therapy is effective (OR = 3.859; 95% CI: 1.482–10.047; P = 0.006, vs not understood), and being willing to discuss ongoing TCM therapy with an attending physician (OR = 62.468; 95% CI: 30.350–128.574; P < 0.001, vs not informed).

Conclusion

This study initially investigated the acceptance, attitude, and independent predictors of TCM use among PD patients. To expand the prevalence of TCM use among patients with PD, we recommend to broadening the public outreach for TCM via contemporary means of Internet and broadcast communication, enhancing access to TCM services in rural communities, and strengthening the communication between doctors and patients.

Please cite this article as: Wang P, Hong J, Tang ZQ, Gong BZ, Qi XR, Jiang H, Pan B, Chen Q. The acceptance of traditional Chinese medicine among patients with Parkinson’s disease: A hospital survey. J Integr Med. 2024; 22(2): 180–187.

帕金森病（Parkinson's disease，PD）的药物疗效往往随着时间的推移而下降，严重影响患者的健康和生活质量。中医药在一定程度上可以解决帕金森病患者多巴胺能药物治疗无效的困扰。本研究旨在调查一家三甲医院门诊部收治的帕金森病患者对中医药的态度、接受程度和独立预测因素。本研究于 2022 年 3 月至 2023 年 6 月在北京一家大型三甲医院门诊部对 PD 患者进行了横断面研究。根据问卷编制了一份自我报告问卷，以调查 PD 患者对中医药的态度和接受程度。为进一步明确影响患者采用中医药治疗的独立预测因素，还进行了多变量逻辑回归分析。共有397名患者填写了问卷，其中78.09%的患者愿意接受中医治疗，21.91%的患者表示不愿意使用中医治疗。多因素逻辑回归分析表明，有几项参数与患者是否愿意将中医纳入其治疗方案相关。这些参数包括本科教育程度（几率比[OR] = 8.554; 95%置信区间[CI]：这些因素包括：教育程度为本科（比值比 [OR] = 8.554；95% 置信区间 [CI]：4.112-17.794；< 0.001，初中教育程度）、居住在城市（比值比 [OR] = 8.022；95% 置信区间 [CI]：4.577-14.060；< 0.001，农村）、患有其他基础疾病（比值比 [OR] = 5.126；95% 置信区间 [CI]：3.078-8.537；< 0.001，无）、以前使用过中医药（比值比 [OR] = 3.083；95% 置信区间 [CI]：1.852-5.134；< 0.001，未使用过）、认为中医药治疗是安全的（比值比 [OR] = 3.530；95% CI：1.446-8.616；=0.006，不认为），认为中医治疗有效（OR=3.859；95% CI：1.482-10.047；=0.006，不了解），愿意与主治医生讨论正在进行的中医治疗（OR=62.468；95% CI：30.350-128.574；<0.001，不了解）。本研究初步调查了PD患者对中医药的接受程度、态度以及使用中医药的独立预测因素。为了扩大中医药在PD患者中的使用率，我们建议通过互联网和广播等现代传播手段扩大中医药的公众宣传，提高农村社区中医药服务的可及性，并加强医患之间的沟通。

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引用次数: 0

Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation 丹红清方通过下调来自胆管细胞的长非编码 RNA H19 和抑制肝星状细胞活化，缓解胆汁淤积性肝纤维化。

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2024-03-01 DOI: 10.1016/j.joim.2024.03.006

Meng Li , Yang Zhou , Hui Zhu , Lie-ming Xu , Jian Ping

Objective

This study explores the mechanism of action of Danhongqing formula (DHQ), a compound-based Chinese medicine formula, in the treatment of cholestatic liver fibrosis.

Methods

In vivo experiments were conducted using 8-week-old multidrug resistance protein 2 knockout (Mdr2^-/-) mice as an animal model of cholestatic liver fibrosis. DHQ was administered orally for 8 weeks, and its impact on cholestatic liver fibrosis was evaluated by assessing liver function, liver histopathology, and the expression of liver fibrosis-related proteins. Real-time polymerase chain reaction, Western blot, immunohistochemistry and other methods were used to observe the effects of DHQ on long non-coding RNA H19 (H19) and signal transducer and activator of transcription 3 (STAT3) phosphorylation in the liver tissue of Mdr2^-/- mice. In addition, cholangiocytes and hepatic stellate cells (HSCs) were cultured in vitro to measure the effects of bile acids on cholangiocyte injury and H19 expression. Cholangiocytes overexpressing H19 were constructed, and a conditioned medium containing H19 was collected to measure its effects on STAT3 protein expression and cell activation. The intervention effect of DHQ on these processes was also investigated. HSCs overexpressing H19 were constructed to measure the impact of H19 on cell activation and assess the intervention effect of DHQ.

Results

DHQ alleviated liver injury, ductular reaction, and fibrosis in Mdr2^-/- mice, and inhibited H19 expression, STAT3 expression and STAT3 phosphorylation. This formula also reduced hydrophobic bile acid-induced cholangiocyte injury and the upregulation of H19, inhibited the activation of HSCs induced by cholangiocyte-derived conditioned medium, and decreased the expression of activation markers in HSCs. The overexpression of H19 in a human HSC line confirmed that H19 promoted STAT3 phosphorylation and HSC activation, and DHQ was able to successfully inhibit these effects.

Conclusion

DHQ effectively alleviated spontaneous cholestatic liver fibrosis in Mdr2^-/- mice by inhibiting H19 upregulation in cholangiocytes and preventing the inhibition of STAT3 phosphorylation in HSC, thereby suppressing cell activation.

Please cite this article as: Li M, Zhou Y, Zhu H, Xu LM, Ping J. Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation. J Integr Med. 2024; 22(2): 188–198.

目的：探讨复方中药丹红清方治疗胆汁淤积性肝纤维化的作用机制：本研究探讨复方中药丹红清方（DHQ）治疗胆汁淤积性肝纤维化的作用机制：以8周龄多耐药蛋白2基因敲除（Mdr2-/-）小鼠为胆汁淤积性肝纤维化动物模型进行体内实验。口服DHQ 8周，通过评估肝功能、肝组织病理学和肝纤维化相关蛋白的表达来评价DHQ对胆汁淤积性肝纤维化的影响。采用实时聚合酶链反应、Western印迹、免疫组化等方法观察了DHQ对Mdr2-/-小鼠肝组织中长非编码RNA H19（H19）和信号转导和激活剂3（STAT3）磷酸化的影响。此外，还对胆管细胞和肝星状细胞（HSCs）进行了体外培养，以测定胆汁酸对胆管细胞损伤和 H19 表达的影响。构建了过表达 H19 的胆管细胞，并收集了含有 H19 的条件培养基，以测量其对 STAT3 蛋白表达和细胞活化的影响。同时还研究了 DHQ 对这些过程的干预作用。构建了过表达H19的造血干细胞，以测量H19对细胞活化的影响并评估DHQ的干预效果：结果：DHQ减轻了Mdr2-/-小鼠的肝损伤、导管反应和纤维化，抑制了H19表达、STAT3表达和STAT3磷酸化。该配方还能减轻疏水胆酸诱导的胆管细胞损伤和H19的上调，抑制胆管细胞源性条件培养基诱导的造血干细胞活化，降低造血干细胞活化标志物的表达。在人造血干细胞系中过表达H19证实，H19能促进STAT3磷酸化和造血干细胞活化，而DHQ能成功抑制这些效应：结论：DHQ通过抑制胆管细胞中H19的上调和防止抑制造血干细胞中STAT3磷酸化，从而抑制细胞活化，有效缓解了Mdr2-/-小鼠自发性胆汁淤积性肝纤维化。本文引用如前Li M, Zhou Y, Zhu H, Xu LM, Ping J. Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation.J Integr Med.2024; Epub ahead of print.

{"title":"Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation","authors":"Meng Li , Yang Zhou , Hui Zhu , Lie-ming Xu , Jian Ping","doi":"10.1016/j.joim.2024.03.006","DOIUrl":"10.1016/j.joim.2024.03.006","url":null,"abstract":"<div><h3>Objective</h3><p>This study explores the mechanism of action of Danhongqing formula (DHQ), a compound-based Chinese medicine formula, in the treatment of cholestatic liver fibrosis.</p></div><div><h3>Methods</h3><p>In vivo experiments were conducted using 8-week-old <em>multidrug resistance protein 2</em> knockout (<em>Mdr2<sup>-/-</sup></em>) mice as an animal model of cholestatic liver fibrosis. DHQ was administered orally for 8 weeks, and its impact on cholestatic liver fibrosis was evaluated by assessing liver function, liver histopathology, and the expression of liver fibrosis-related proteins. Real-time polymerase chain reaction, Western blot, immunohistochemistry and other methods were used to observe the effects of DHQ on long non-coding RNA <em>H19</em> (<em>H19</em>) and signal transducer and activator of transcription 3 (STAT3) phosphorylation in the liver tissue of <em>Mdr2<sup>-/-</sup></em> mice. In addition, cholangiocytes and hepatic stellate cells (HSCs) were cultured in vitro to measure the effects of bile acids on cholangiocyte injury and <em>H19</em> expression. Cholangiocytes overexpressing <em>H19</em> were constructed, and a conditioned medium containing <em>H19</em> was collected to measure its effects on STAT3 protein expression and cell activation. The intervention effect of DHQ on these processes was also investigated. HSCs overexpressing <em>H19</em> were constructed to measure the impact of <em>H19</em> on cell activation and assess the intervention effect of DHQ.</p></div><div><h3>Results</h3><p>DHQ alleviated liver injury, ductular reaction, and fibrosis in <em>Mdr2<sup>-/-</sup></em> mice, and inhibited <em>H19</em> expression, STAT3 expression and STAT3 phosphorylation. This formula also reduced hydrophobic bile acid-induced cholangiocyte injury and the upregulation of <em>H19</em>, inhibited the activation of HSCs induced by cholangiocyte-derived conditioned medium, and decreased the expression of activation markers in HSCs. The overexpression of <em>H19</em> in a human HSC line confirmed that <em>H19</em> promoted STAT3 phosphorylation and HSC activation, and DHQ was able to successfully inhibit these effects.</p></div><div><h3>Conclusion</h3><p>DHQ effectively alleviated spontaneous cholestatic liver fibrosis in <em>Mdr2<sup>-/-</sup></em> mice by inhibiting <em>H19</em> upregulation in cholangiocytes and preventing the inhibition of STAT3 phosphorylation in HSC, thereby suppressing cell activation.</p><p>Please cite this article as: Li M, Zhou Y, Zhu H, Xu LM, Ping J. Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA <em>H19</em> derived from cholangiocytes and inhibiting hepatic stellate cell activation. <em>J Integr Med.</em> 2024; 22(2): 188–198.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 188-198"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential hypertension: A systematic review and meta-analysis 刮痧疗法对I期和II期原发性高血压患者血压和睡眠质量的影响:一项系统综述和荟萃分析

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Integrative Medicine-Jim

Pub Date : 2024-01-01 DOI: 10.1016/j.joim.2023.11.006

Zheng-gang Zhu , Jian-ru Wang , Xiao-yan Pan

<div><h3>Background</h3><p>Scraping therapy is widely used in treating stage I and II essential hypertension in China. However, there has been no systematic evaluation of the efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential hypertension.</p></div><div><h3>Search strategy</h3><p>Seven electronic databases (PubMed, Scopus, Cochrane Library, Web of Science, EBSCO, China National Knowledge Infrastructure and Wanfang Data electronic databases) were searched from inception to December 2022. Based on the principle of combining subject words with text words, the search strategy was constructed around search terms for “scraping therapy,” “scraping,” “<em>Guasha</em>,” “<em>Gua sha</em>,” “hypertension,” and “high blood pressure” during the database searches.</p></div><div><h3>Inclusion criteria</h3><p>Randomized controlled trials (RCTs) were included if they recruited patients with stage I and II essential hypertension and included a scraping therapy intervention. The intervention group received antihypertensive drugs and scraping therapy, while the control group only took antihypertensive drugs.</p></div><div><h3>Data extraction and analysis</h3><p>Review Manager 5.4.0 and STATA 15.1 were used to enter all the relevant outcome variables to conduct the meta-analysis. The quality of the selected RCTs was assessed using the PEDro scale. The sensitivity analysis was carried out by iteratively excluding individual studies and repeating the analysis to determine the stability of the findings and identify any studies with greater influence on the outcome. Subgroup analysis was performed to find the source of heterogeneity. Funnel plots were used to evaluate the publication bias of included studies.</p></div><div><h3>Results</h3><p>Nine RCTs including 765 participants were selected. Meta-analysis showed that scraping therapy combined with medication had an advantage over the use of medication alone in lowering systolic blood pressure (mean difference [MD] = −5.09, 95% confidence interval [CI] = −6.50 to −3.67, <em>P</em> < 0.001) and diastolic blood pressure (MD = −2.66, 95% CI = −3.17 to −2.14, <em>P</em> < 0.001). Subgroup analysis showed that scraping therapy improved sleep quality in middle-aged patients with hypertension, but the efficacy was better in elderly patients (MD = −7.91, 95% CI = −8.65 to −7.16, <em>P</em> < 0.001) than in middle-aged patients (MD = −2.67, 95% CI = −4.12 to −1.21, <em>P</em> = 0.0003).</p></div><div><h3>Conclusion</h3><p>The available evidence indicates that scraping therapy has significant effects on patients with stage I and II hypertension, and it improves sleep quality for elderly patients with hypertension better than for middle-aged ones. Scraping therapy can be an adjunctive treatment for stage I and II essential hypertension. However, further high-quality studies are needed to verify its effectiveness and the best therapeutic strategies.</p><p>Please cite this article a

背景刮痧疗法在中国广泛应用于治疗I期和II期原发性高血压。然而，目前还没有系统的评价刮痧疗法对I期和II期原发性高血压患者血压和睡眠质量的影响。检索策略:检索自成立至2022年12月的7个电子数据库(PubMed、Scopus、Cochrane Library、Web of Science、EBSCO、中国知网和万方数据电子数据库)。基于主题词与文本词相结合的原则，在数据库搜索过程中围绕“刮痧疗法”、“刮痧”、“瓜沙”、“瓜沙”、“高血压”、“高血压”等搜索词构建搜索策略。纳入标准:纳入随机对照试验(RCTs)，如果他们招募了I期和II期原发性高血压患者，并包括刮痧治疗干预。干预组给予降压药和刮痧治疗，对照组只服用降压药。数据提取与分析:使用Review Manager 5.4.0和STATA 15.1输入所有相关结局变量进行meta分析。采用PEDro量表对所选随机对照试验的质量进行评估。敏感性分析是通过反复排除个别研究并重复分析来确定结果的稳定性并确定对结果影响较大的研究来进行的。进行亚组分析以寻找异质性的来源。采用漏斗图评价纳入研究的发表偏倚。结果共纳入9项随机对照试验，共纳入受试者765人。meta分析显示，刮痧疗法联合药物治疗在降低收缩压方面优于单独使用药物治疗(平均差值[MD] = -5.09, 95%可信区间[CI] = -6.50 ~ -3.67, P <0.001)和舒张压(MD = -2.66, 95% CI = -3.17 ~ -2.14, P <0.001)。亚组分析显示，刮痧疗法改善了中年高血压患者的睡眠质量，但老年患者的效果更好(MD = -7.91, 95% CI = -8.65 ~ -7.16, P <0.001)高于中年患者(MD = -2.67, 95% CI = -4.12 ~ -1.21, P = 0.0003)。结论现有证据表明刮痧疗法对ⅰ、ⅱ期高血压患者有显著疗效，且对老年高血压患者睡眠质量的改善效果优于中年高血压患者。刮痧治疗可作为I期和II期原发性高血压的辅助治疗。然而，需要进一步的高质量研究来验证其有效性和最佳治疗策略。这篇文章的署名为:朱志刚，王小杰，潘晓霞。刮痧疗法对I期和II期原发性高血压患者血压和睡眠质量的影响:一项系统综述和荟萃分析。中华医学杂志;2009;打印前Epub。

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引用次数: 0