Journal of Integrative Medicine-Jim最新文献

{"title":"Placebo effect of sham acupuncture in patients with insomnia and influence of varying stimulation intensities and locations: A systematic review and meta-analysis.","authors":"Jing-Ying Chi, Rui-Xin Zhu, Cheng Chen, Run-Lei Xu, Chang-Zi Lyu, Ji-Xuan Yao, Man-Qian Fu, De-Jun Wang, Ge-Shu Du","doi":"10.1016/j.joim.2025.10.006","DOIUrl":"https://doi.org/10.1016/j.joim.2025.10.006","url":null,"abstract":"<p><strong>Background: </strong>Sham acupuncture is commonly used as a control in clinical acupuncture trials. However, its placebo effects remain unclear, and there is no standardized protocol regarding stimulation intensity or needling location.</p><p><strong>Objective: </strong>Using randomized controlled trials (RCTs) of acupuncture for insomnia as an example, this study aimed to evaluate the placebo effect of sham acupuncture and to analyze how stimulation intensity and acupoint location influence this effect.</p><p><strong>Search strategy: </strong>A comprehensive search was conducted in PubMed, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Wanfang, and Chinese Scientific Journals Database from the inception until January 25, 2025.</p><p><strong>Inclusion criteria: </strong>Eligible studies were RCTs involving participants diagnosed with insomnia or other sleep disorders that compared acupuncture to sham acupuncture. No restrictions were placed on disease duration or severity.</p><p><strong>Data extraction and analysis: </strong>Primary outcome measures were Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI). Secondary outcomes included total sleep time, sleep efficiency, sleep awakening time, and PSQI scores at a 4-week follow-up. Studies reporting at least one primary outcome were eligible for inclusion. For continuous outcomes, mean difference (MD) with 95% confidence interval (CI) were calculated. When measurement units were inconsistent or outcome variability was high, standardized MD (SMD) and 95% CI were calculated. Pairwise meta-analyses were conducted using Review Manager 5.4, while network meta-analyses were performed using Stata 16. The risk of bias was assessed using the Cochrane risk of bias tool.</p><p><strong>Results: </strong>A total of 15 RCTs involving 609 participants were included. Compared to baseline, sham acupuncture significantly improved PSQI scores (MD = 1.43; 95% CI: [0.91, 1.94]; P < 0.0001; I<sup>2</sup> = 61%) and sleep efficiency (MD = -2.53; 95% CI: [-4.77, -0.29]; P = 0.03; I<sup>2</sup> = 91%). Subgroup analysis revealed that low-intensity stimulation and medium-frequency treatment (13-20 sessions) were associated with stronger placebo effects. The network meta-analysis suggested a potential interaction between stimulation intensity and treatment location. Among all subgroups, sham acupuncture performed at non-meridian, non-acupoint locations using low-intensity stimulation produced the greatest placebo effects in terms of PSQI improvement, ISI reduction, and prolongation of sleep duration, achieving the highest value of surface under the cumulative ranking curve.</p><p><strong>Conclusion: </strong>Sham acupuncture produces a measurable and relatively stable placebo effect in insomnia patients. The effectiveness varied across different sham protocols, with low-intensity stimulation and medium-frequency regimens (13-20 sessions) showing ","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145459988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Jinhua Qinggan Granule, a compound Chinese herbal medicine, in oldest-old patients with COVID-19: A retrospective cohort study.","authors":"Lei-Lei Chen, Wen-Jing Zhai, Juan Bao, Zheng-Hao Yu, Tian-Yi Zhang, Xue-Chun Lu, Lin Liu, Li Chen, Su-Yang Wang, Jing Hu, Xin Gao, Qi Zhang, Guo-Gang Xu, Hai-Li Xin","doi":"10.1016/j.joim.2025.10.005","DOIUrl":"https://doi.org/10.1016/j.joim.2025.10.005","url":null,"abstract":"<p><strong>Objective: </strong>Limited data are available on the use of antiviral drugs among oldest-old patients. This study investigates the effect of Jinhua Qinggan Granule (JHQG), a compound Chinese herbal medicine, on the efficacy and safety of nirmatrelvir/ritonavir in oldest-old patients with coronavirus disease 2019 (COVID-19).</p><p><strong>Methods: </strong>A total of 180 oldest-old patients with confirmed COVID-19 at the Chinese PLA General Hospital from July 2023 to July 2024 were enrolled in this retrospective cohort study and were divided into a monotherapy group (nirmatrelvir/ritonavir, n = 89) and a combination therapy group (nirmatrelvir/ritonavir plus JHQG, n = 91) according to the treatments received. The primary outcome was the cumulative rate of nucleic acid negative conversion (NANC) on the fifth day after initiation of treatment. The secondary outcomes included the rates of improvement in the main symptoms, the duration of fever, and variations in clinical laboratory indices. The safety outcomes included the incidence of adverse drug reactions (ADRs) and indicators of liver and kidney function.</p><p><strong>Results: </strong>Among the 180 oldest-old patients participating in the study, the median (P25, P75) age was 93.0 (86.0, 96.0) years, and 94.44% were male. The rate of NANC within five days was significantly higher in the combination therapy group than in the monotherapy group (80.22% vs 66.29%, P = 0.035). The addition of JHQG was significantly associated with NANC within five days in the multivariable analysis (odds ratio [OR] = 2.216; 95% confidence interval [CI]: 1.066-4.607; P = 0.033). Furthermore, compared with nirmatrelvir/ritonavir alone, combination therapy had better effects on the recovery rates of various symptoms, including fever, cough, expectoration, and all respiratory symptoms, as well as the time to recovery from fever (P < 0.05). There were also significant differences between the two groups in terms of improvement in C-reactive protein (P < 0.05). Moreover, no significant differences were observed in the incidence of ADRs or in liver and kidney function indicators (P > 0.05).</p><p><strong>Conclusion: </strong>Among oldest-old patients with COVID-19, the addition of JHQG to nirmatrelvir/ritonavir significantly improves early clinical recovery without increasing safety concerns. Please cite this article as: Chen LL, Zhai WJ, Bao J, Yu ZH, Zhang TY, Lu XC, Liu L, Chen L, Wang SY, Hu J, Gao X, Zhang Q, Xu GG, Xin HL. Efficacy and safety of Jinhua Qinggan Granule, a compound Chinese herbal medicine, in oldest-old patients with COVID-19: A retrospective cohort study. J Integr Med. 2025.</p>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of transcutaneous electrical acupoint stimulation combined with press needle therapy for pain control after caesarean section: A randomized controlled trial.","authors":"Pei-Pei Qin, Ke Wei, Bing-Yu Zou, Dan Liu, Ming-Xi Li, Xiao-Nan Liu, Lei Zou, Bin Wu","doi":"10.1016/j.joim.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.joim.2025.10.002","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Optimizing analgesia following caesarean section is essential for improving maternal rehabilitation and fostering maternal-infant bonding.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The purpose of this study was to evaluate the safety and effectiveness of transcutaneous electrical acupoint stimulation (TEAS) combined with press needle therapy as an adjunctive approach for postoperative pain control following caesarean section.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, participants and interventions: &lt;/strong&gt;One hundred women with singleton term pregnancies who were schedule to undergo caesarean section births under combined spinal-epidural anesthesia were recruited. Patients were randomly assigned to the acupuncture group (n = 50) or sham-acupuncture group (n = 50). The acupuncture group received pre- and intraoperative TEAS combined with postoperative press needle therapy. The sham-acupuncture group received a sham acupuncture intervention.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcome measures: &lt;/strong&gt;The primary outcome was total cumulative morphine consumption at 48 h. Secondary outcomes included pain scores, morphine consumption and patient satisfaction. Analgesic-related adverse effects and acupuncture-related side effects were recorded.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Overall, 100 patients were included in the intention-to-treat analysis. Median (interquartile range [range]) of cumulative morphine consumption at 48 h in the acupuncture group was lower than that in the sham-acupuncture group (22.9 [16.9-28.9] mg vs 34.9 [22.4-39.4] mg), with an estimated median difference of -10.0 mg (95% confidence interval, [-14.0, -4.0]; P &lt; 0.001). The generalized estimating equation analysis also revealed that cumulative morphine consumption was significantly lower in the acupuncture group than in the sham-acupuncture group at 6, 12 and 24 h (P &lt; 0.001). In addition, patients in the acupuncture group reported lower pain scores both at rest and during movement at 6, 12 and 24 h compared to those in the sham-acupuncture group (P &lt; 0.001). Furthermore, acupuncture improved patient satisfaction (P &lt; 0.001) and decreased the incidence of nausea and vomiting after surgery (12% vs 30%; P = 0.03). None of the patients in the study experienced any acupuncture-related side effects.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;As a non-pharmacological approach, TEAS combined with press needle therapy safely and effectively reduced postoperative morphine consumption and alleviated postoperative pain in women who underwent caesarean sections, recommending it as a routine complementary treatment for postpartum analgesia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Trial registration: &lt;/strong&gt;The protocol was registered at the Chinese Clinical Trial Registry (ChiCTR2400086645). Please cite this article as: Qin PP, Wei K, Zou BY, Liu D, Li MX, Liu XN, Zou L, Wu B. Effectiveness of transcutaneous electrical acupoint stimulation combined with press needle therapy for pain control after caesarean section: A rando","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture is an effective alternative to medication for migraine: An umbrella review.","authors":"Paulo Alexandre Pereira, Carlos Miguel Marto, Bárbara Oliveiros, Maria Filomena Botelho","doi":"10.1016/j.joim.2025.10.003","DOIUrl":"https://doi.org/10.1016/j.joim.2025.10.003","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Migraine is a highly prevalent primary headache disorder that impacts individuals and societies around the globe. Acupuncture can be used in migraine treatment and prevention due to its analgesic effects, safety profile, and modulation of neural pathways. However, there is a lack of conclusive evidence, and some reports present conflicting results.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aim of this umbrella review is to evaluate the effectiveness of acupuncture in migraine treatment, comparing it to the standard pharmacological treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Search strategy: &lt;/strong&gt;MEDLINE (via PubMed), Embase, Web of Science (all databases), Cochrane, and Epistemonikos databases were searched for articles published prior to February 2024 in English, Portuguese, French and Spanish, and no date restriction was applied.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Inclusion criteria: &lt;/strong&gt;Systematic reviews, with or without meta-analysis, of randomized controlled trials, comparing acupuncture with standard pharmacological treatment were included. Patients of all ages diagnosed with episodic or chronic migraine, with or without aura, according to international guidelines were included. The main outcome was the pain intensity. Secondary outcomes included days with migraine per month, response rate, quality of life, dropout rate, use of rescue medication, and adverse events.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data extraction and analysis: &lt;/strong&gt;Articles were initially evaluated based on the title and abstract, and later based on the full text, independently by two reviewers. For the meta-analysis, data were extracted from the primary studies, and a random effects model was used. The methodological quality of the included reviews was evaluated using the AMSTAR 2 tool and the degree of overlap was also evaluated. The certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Twenty-two reviews encompassing 24,635 patients were included. Most systematic reviews reported greater improvements and better tolerability in the acupuncture group. The meta-analysis showed a statistically significant reduction in pain intensity (standard mean difference [SMD]: -2.17; 95% confidence interval [CI] [-3.25; -1.10]; P &lt; 0.001) and in days with migraine per month (SMD: -2.92; 95% CI [-4.65; -1.20]; P &lt; 0.001), both favoring acupuncture, but high heterogeneity among results was found. Subgroup analysis confirmed that this reduction persisted at 3 months after cessation of treatment. However, the outcome variables for response to treatment and occurrence of adverse events did not meet the threshold for statistical significance. The quality of included reviews was low to moderate, and the degree of overlap was considered moderate.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Acupuncture is a safe and effective alternative to medication for migraine. It should be considered as a preventive treatmen","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture in depression treatment: Insights into astrocyte regulation.","authors":"Ning Xu, Tao Huang, Long Wang","doi":"10.1016/j.joim.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.joim.2025.09.003","url":null,"abstract":"<p><p>Astrocytes are the most abundant and morphologically intricate glial cells in the central nervous system, playing diverse and crucial roles in maintaining homeostasis within this system. Increasing evidence suggests that dysfunction of astrocytes contributes to the pathophysiology of depression. As an adjunctive and integrative therapy, acupuncture presents certain advantages in alleviating the severity of depressive symptoms. In comparison to conventional pharmacotherapy, acupuncture is distinguished by its relatively rapid onset of action, minimal side effects, and compatibility with concurrent pharmacological treatments. Preclinical studies indicate that acupuncture can ameliorate both morphological and functional impairments observed in the depressed brain by targeting neurons and glia. Specifically, research has demonstrated that acupuncture reduces morphological atrophy in astrocytes while also mitigating their dysfunction in rat models of depression. This therapeutic effect may be partially mediated through the regulation of enzyme expression, cytokines, neurotrophic factors, and intracellular signaling pathways within these glial cells. This review focuses on preclinical research investigating the mechanisms through which acupuncture may aid in treating depression, with an emphasis on astrocyte modulation. Please cite this article as: Xu N, Huang T, Wang L. Acupuncture in depression treatment: Insights into astrocyte regulation. J Integr Med. 2025; Epub ahead of print.</p>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvia miltiorrhiza components and gut microbiota interactions in Helicobacter pylori infection","authors":"Shao-jian Li ,&nbsp;Jin-xin Miao ,&nbsp;Fei Wang ,&nbsp;Hao-yu Wang ,&nbsp;Yao-wu Ma ,&nbsp;Ying Jiang ,&nbsp;Xia Xue","doi":"10.1016/j.joim.2025.07.006","DOIUrl":"10.1016/j.joim.2025.07.006","url":null,"abstract":"<div><div><em>Salvia miltiorrhiza</em> (Danshen) is a traditional Chinese herb that is commonly known for its cardiovascular and hepatoprotective benefits. Recent studies have confirmed that Danshen and its bioactive components can influence gut microbial homeostasis, thereby affecting <em>Helicobacter pylori</em> (HP) colonization in the human stomach. HP is a bacterial pathogen associated with various gastrointestinal diseases. Current HP treatments mainly involve antibiotics and proton pump inhibitors. However, their efficacy is strongly compromised by the rapid emergence of antibiotic resistance in HP and genetic heterogeneity among patients. The interaction between Danshen and gut microbial status provides a novel perspective for HP treatment. Understanding the medical properties of Danshen in altering gut microbiota and eliminating HP, as well as the underlying mechanisms, is important for improving human gastrointestinal healthcare. This review investigates the interaction between Danshen and gut microbiota and its impact on HP infection using databases including Web of Science, PubMed, and Google Scholar. We explored the unconventional intersection between Danshen, gut microbiota, and HP infection, shedding light on their intricate interplay and potential therapeutic implications. A comprehensive understanding of this interaction provides valuable insights into developing novel therapeutic strategies that target the gut microbiota to mitigate HP-associated gastrointestinal disorders.</div><div><br>Please cite this article as: Li SJ, Miao JX, Wang F, Wang HY, Ma YW, Jiang Y, Xue X. <em>Salvia miltiorrhiza</em> components and gut microbiota interactions in <em>Helicobacter pylori</em> infection. <em>J Integr Med</em>. 2025; 23(5):462–470.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"23 5","pages":"Pages 462-470"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture alleviates behaviors associated with posttraumatic stress disorder by modulating lipocalin-2-mediated neuroinflammation and neuronal activity in the prefrontal cortex","authors":"Yu-die Yang ,&nbsp;Wen Zhong ,&nbsp;Ming Chen ,&nbsp;Qing-chen Tang ,&nbsp;Yan Li ,&nbsp;Lu-lu Yao ,&nbsp;Mei-qi Zhou ,&nbsp;Neng-gui Xu ,&nbsp;Shuai Cui","doi":"10.1016/j.joim.2025.07.002","DOIUrl":"10.1016/j.joim.2025.07.002","url":null,"abstract":"<div><h3>Objective</h3><div>To elucidate the specific mechanisms by which electroacupuncture (EA) alleviates anxiety and fear behaviors associated with posttraumatic stress disorder (PTSD), focusing on the role of lipocalin-2 (Lcn2).</div></div><div><h3>Methods</h3><div>The PTSD mouse model was subjected to single prolonged stress and shock (SPS&amp;S), and the animals received 15 min sessions of EA at Shenmen acupoint (HT7). Behavioral tests were used to investigate the effects of EA at HT7 on anxiety and fear. Western blotting and enzyme-linked immunosorbent assay were used to quantify Lcn2 and inflammatory cytokine levels in the prefrontal cortex (PFC). Additionally, the activity of PFC neurons was evaluated by immunofluorescence and in vivo electrophysiology.</div></div><div><h3>Results</h3><div>Mice subjected to SPS&amp;S presented increased anxiety- and fear-like behaviors. Lcn2 expression in the PFC was significantly upregulated following SPS&amp;S, leading to increased expression of the proinflammatory cytokines tumor necrosis factor-α and interleukin-6 and suppression of PFC neuronal activity. However, EA at HT7 inhibited Lcn2 release, reducing neuroinflammation and hypoexcitability in the PFC. Lcn2 overexpression mitigated the effects of EA at HT7, resulting in anxiety- and fear-like behaviors.</div></div><div><h3>Conclusion</h3><div>EA at HT7 can ameliorate PTSD-associated anxiety and fear, and its mechanism of action appears to involve the inhibition of Lcn2-mediated neural activity and inflammation in the PFC.</div><div>Please cite this article as: Yang YD, Zhong W, Chen M, Tang QC, Li Y, Yao LL, et al. Electroacupuncture alleviates behaviors associated with posttraumatic stress disorder by modulating lipocalin-2-mediated neuroinflammation and neuronal activity in the prefrontal cortex. <em>J Integr Med</em>. 2025; 23(5):537–547.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"23 5","pages":"Pages 537-547"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International clinical practice guideline on the use of traditional Chinese medicine for functional dyspepsia (2025)","authors":"Sheng-sheng Zhang ,&nbsp;Lu-qing Zhao ,&nbsp;Xiao-hua Hou ,&nbsp;Zhao-xiang Bian ,&nbsp;Jian-hua Zheng ,&nbsp;Hai-he Tian ,&nbsp;Guan-hu Yang ,&nbsp;Won-sook Hong ,&nbsp;Yu-ying He ,&nbsp;Li Liu ,&nbsp;Hong Shen ,&nbsp;Yan-ping Li ,&nbsp;Sheng Xie ,&nbsp;Jin Shu ,&nbsp;Bin-fang Zeng ,&nbsp;Jun-xiang Li ,&nbsp;Zhen Liu ,&nbsp;Zheng-hua Xiao ,&nbsp;Jing-dong Xiao ,&nbsp;Pei-yong Zheng ,&nbsp;Gui-jun Fei","doi":"10.1016/j.joim.2025.05.002","DOIUrl":"10.1016/j.joim.2025.05.002","url":null,"abstract":"<div><div>Functional dyspepsia (FD), characterized by persistent or recurrent dyspeptic symptoms without identifiable organic, systemic or metabolic causes, is an increasingly recognized global health issue. The objective of this guideline is to equip clinicians and nursing professionals with evidence-based strategies for the management and treatment of adult patients with FD using traditional Chinese medicine (TCM). The Guideline Development Group consulted existing TCM consensus documents on FD and convened a panel of 35 clinicians to generate initial clinical queries. To address these queries, a systematic literature search was conducted across PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP Database, China Biology Medicine (SinoMed) Database, Wanfang Database, Traditional Medicine Research Data Expanded (TMRDE), and the Traditional Chinese Medical Literature Analysis and Retrieval System (TCMLARS). The evidence from the literature was critically appraised using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. The strength of the recommendations was ascertained through a consensus-building process involving TCM and allopathic medicine experts, methodologists, pharmacologists, nursing specialists, and health economists, leveraging their collective expertise and empirical knowledge. The guideline comprises a total of 43 evidence-informed recommendations that span a range of clinical aspects, including the pathogenesis according to TCM, diagnostic approaches, therapeutic interventions, efficacy assessments, and prognostic considerations.</div><div>Please cite this article as: Zhang SS, Zhao LQ, Hou XH, Bian ZX, Zheng JH, Tian HH, Yang GH, Hong WS, He YY, Liu L, Shen H, Li YP, Xie S, Shu J, Zeng BF, Li JX, Liu Z, Xiao ZH, Xiao JD, Zheng PY, Huang SG, Chen SL, Fei GJ. International clinical practice guideline on the use of traditional Chinese medicine for functional dyspepsia (2025). <em>J Integr Med</em>. 2025; 23(5):502–518.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"23 5","pages":"Pages 502-518"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture at ST36 improves gastrointestinal motility disorders by promoting enteric nervous system regeneration through GDNF/Ret signaling in diabetic mice","authors":"Jin-lu Guo,&nbsp;Shi Liu,&nbsp;Sheng-jie Ding,&nbsp;Xin Yang,&nbsp;Fan Du","doi":"10.1016/j.joim.2025.07.007","DOIUrl":"10.1016/j.joim.2025.07.007","url":null,"abstract":"<div><h3>Objective</h3><div>Diabetes-induced gastrointestinal (GI) motility disorders are increasingly prevalent. Damage to the enteric nervous system (ENS), composed primarily of enteric neurons and glial cells, is an essential mechanism involved in these disorders. Although electroacupuncture (EA) has shown the potential to mitigate enteric neuronal loss, its mechanism is not fully understood. Additionally, the effects of EA on enteric glial cells have not been investigated. Enteric neural precursor cells (ENPCs) contribute to the structural and functional integrity of the ENS, yet whether EA enhances their differentiation into enteric neurons and glial cells remains unexplored. This study investigates whether EA promotes ENS repair through enhancing ENPC-derived neurogenesis and gliogenesis and elucidates the potential molecular mechanisms involved.</div></div><div><h3>Methods</h3><div>Transgenic mice were used to trace Nestin⁺/nerve growth factor receptor (Ngfr)⁺ ENPCs labeled with green fluorescent protein (GFP) in vivo. Mice were randomly divided into four groups: control, diabetes mellitus (DM), DM + sham EA, and DM + EA. The effects of EA on diabetic mice were evaluated by GI motility, ENS structure, and ENPC differentiation. Glial cell line-derived neurotrophic factor (GDNF)/Ret signaling was detected to clarify the underlying molecular mechanisms.</div></div><div><h3>Results</h3><div>EA alleviated diabetes-induced GI motility disorders, as indicated by reduced whole gut transit time, shortened colonic bead expulsion time, and enhanced smooth muscle contractility. Furthermore, EA attenuated diabetes-induced losses of enteric neurons and glial cells, thereby restoring ENS integrity. Notably, EA reversed the diabetes-induced decrease in ENPCs and significantly increased the absolute number and the proportion of ENPC-derived enteric neurons. However, immunofluorescence analyses revealed no colocalization between EA-induced glial fibrillary acidic protein⁺ glial cells and GFP-labeled ENPCs. Mechanistically, GDNF/Ret signaling was elevated in intestinal tissues and upregulated in ENPCs in EA-treated diabetic mice.</div></div><div><h3>Conclusion</h3><div>EA facilitates ENS repair by promoting Nestin⁺/Ngfr⁺ ENPC differentiation into enteric neurons via upregulation of GDNF/Ret signaling, and driving enteric gliogenesis from non-Nestin⁺/Ngfr⁺ ENPCs. These findings highlight EA’s role in ameliorating diabetes-induced GI dysmotility through ENPC-derived ENS restoration.</div><div><br>Please cite this article as: Guo JL, Liu S, Ding SJ, Yang X, Du F. Electroacupuncture at ST36 improves gastrointestinal motility disorders by promoting enteric nervous system regeneration through GDNF/Ret signaling in diabetic mice. <em>J Integr Med</em>. 2025; 23(5):548–559.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"23 5","pages":"Pages 548-559"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baicalein attenuates lipopolysaccharide-induced myocardial injury by inhibiting ferroptosis via miR-299b-5p/HIF1-α pathway","authors":"Wen-yan Zhou ,&nbsp;Jian-kui Du ,&nbsp;Hong-hong Liu ,&nbsp;Lei Deng ,&nbsp;Kai Ma ,&nbsp;Jian Xiao ,&nbsp;Sheng Zhang ,&nbsp;Chang-nan Wang","doi":"10.1016/j.joim.2025.07.001","DOIUrl":"10.1016/j.joim.2025.07.001","url":null,"abstract":"<div><h3>Objective</h3><div>Baicalein has been reported to have wide therapeutic effects that act through its anti-inflammatory activity. This study examines the effect and mechanism of baicalein on sepsis-induced cardiomyopathy (SIC).</div></div><div><h3>Methods</h3><div>A thorough screening of a small library of natural products, comprising 100 diverse compounds, was conducted to identify the most effective drug against lipopolysaccharide (LPS)-treated H9C2 cardiomyocytes. The core target proteins and their associated signaling pathways involved in baicalein’s efficacy against LPS-induced myocardial injury were predicted by network pharmacology.</div></div><div><h3>Results</h3><div>Baicalein was identified as the most potent protective agent in LPS-exposed H9C2 cardiomyocytes. It exhibited a dose-dependent inhibitory effect on cell injury and inflammation. In the LPS-induced septic mouse model, baicalein demonstrated a significant capacity to mitigate LPS-triggered myocardial deficits, inflammatory responses, and ferroptosis. Network pharmacological analysis and experimental confirmation suggested that hypoxia-inducible factor 1 subunit α (HIF1-α) is likely to be the crucial factor in mediating the impact of baicalein against LPS-induced myocardial ferroptosis and injury. By combining microRNA (miRNA) screening in LPS-treated myocardium with miRNA prediction targeting <em>HIF1-α</em>, we found that miR-299b-5p may serve as a regulator of HIF1-α. The reduction in miR-299b-5p levels in LPS-treated myocardium, compared to the control group, was reversed by baicalein treatment. The reverse transcription quantitative polymerase chain reaction, Western blotting, and dual-luciferase reporter gene analyses together identified <em>HIF1-α</em> as the target of miR-299b-5p in cardiomyocytes.</div></div><div><h3>Conclusion</h3><div>Baicalein mitigates SIC at the miRNA level, suggesting the therapeutic potential of it in treating SIC through the regulation of miR-299b-5p/HIF1-α/ferroptosis pathway.</div><div><br> Please cite this article as: Zhou WY, Du JK, Liu HH, Deng L, Ma K, Xiao J, Zhang S, Wang CN. Baicalein attenuates lipopolysaccharide-induced myocardial injury by inhibiting ferroptosis via miR-299b-5p/HIF1-α pathway. <em>J Integr Med</em>. 2025; 23(5):560–575.</div></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"23 5","pages":"Pages 560-575"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}