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Oral & Maxillofacial Space Infections-A 10-Year Retrospective Study 口服,颌面部间隙感染的10年回顾性研究
2区 医学 Q1 PATHOLOGY Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000153
Ashok Kumar
Oral & Maxillofacial space infections have been recognized since the time of Galen in the second century. In spite of great advances in health care, these infections remain a major problem. Oral & Maxillofacial space infection ranges from periapical abscess to superficial and deep neck infections. The infections generally follow the path of least resistance through connective tissue and along fascial planes [1]. The infections spread to distant sites from the site of origin. Oral & Maxillofacial infections can be potentially lethal infections, at times. Various life-threatening complications associated with oral & maxillofacial infections are respiratory obstruction, necrotizing fasciitis, descending mediastinitis, pericarditis, brain abscess, and sepsis. The successful management of orofacial infection depends on the early recognition of orofacial infection. Appropriate and prompt therapy is mandatory for successful management. Thorough knowledge of anatomy is necessary to predict pathways of spread and to drain these spaces adequately. We present our experience in treating oral & maxillofacial space infection at our centre
口服,颌面部空间感染自公元2世纪盖伦时代开始被认识。尽管在卫生保健方面取得了巨大进步,但这些感染仍然是一个主要问题。口服,颌面部间隙感染的范围从根尖周围脓肿到颈部浅表和深部感染。感染通常沿着结缔组织和筋膜平面的阻力最小的路径[1]。感染传播到远离发源地的地方。口服,颌面感染有时可能是致命的感染。各种危及生命的并发症与口腔和;颌面部感染包括呼吸阻塞、坏死性筋膜炎、降纵隔炎、心包炎、脑脓肿和败血症。口腔感染的成功治疗依赖于对感染的早期识别。适当和及时的治疗是成功管理的必要条件。透彻的解剖学知识对于预测扩散途径和充分排出这些空间是必要的。我们介绍了治疗口腔溃疡的经验。我们中心的颌面间隙感染
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引用次数: 0
Compartment Syndrome of the Hand after Multiple Fractures of the Metacarpals: A Rare Localization with a Poor Prognosis: Two Case Reports and a Literature Review 掌骨多处骨折后的手部筋膜室综合征:一种罕见且预后不良的局部症状:2例报告及文献综述
2区 医学 Q1 PATHOLOGY Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000156
Bouziane W
Compartment syndrome is a surgical emergency. In fact, it is a “race against the clock” we will discuss our experience with two cases who presented with hand compartment syndrome after suffering numerous metacarpal fractures The treatment included a discharge incisions, metacarpal pinning, and close hand surveillance.
筋膜间室综合征是一种外科急诊。事实上,这是一场“与时间赛跑”,我们将讨论我们的两个病例的经验,他们在经历了多次掌骨骨折后出现了手室综合征,治疗包括一个出院切口,掌骨钉住,和密切的手部监视。
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引用次数: 0
A Case of Polymyositis Treated with the Homoeopathic Medicine Lathyrus Satyvus 顺势疗法治疗多肌炎1例
2区 医学 Q1 PATHOLOGY Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000158
Yasmin Firdaus A
Polymyositis is one of the idiopathic inflammatory myopathies, a rare connective tissue disorders defined by the presence of weakness of muscles and inflammation. The estimated prevalence of polymyositis and dermatomyositis is 5 to 22 per 100,000 persons, and the incidence is approximately 1.2 to 19 per million persons at risk per year. Polymyositis rarely occurs in the paediatric age group, and the mean age is between 50 to 60 years. This article is on a case of polymyositis which was completely bed ridden before reaching our hospital. With thorough case taking and finding out the Totality Lathyrus Sativus 200 was prescribed. Muscle strength grading was done to evaluate the improvement before and after treatment. The case started improving within a period of 1 week. The muscle strength grading which was Grade 1 during the beginning of treatment improved to Grade 3 within a period of 1 month. The improvement was gradual and also within a period of 1 month the patient started walking with support. This shows the management of polymyositis with the Homeopathic medicine Lathyrus Sativus.
多发性肌炎是一种特发性炎症性肌病,是一种罕见的结缔组织疾病,其特征是肌肉无力和炎症。据估计,多发性肌炎和皮肌炎的患病率为每10万人中有5至22人,每年的发病率约为每百万高危人群中有1.2至19人。多发性肌炎很少发生在儿科年龄组,平均年龄在50至60岁之间。这篇文章是关于一例多肌炎患者在到达我们医院之前完全卧床不起。经过彻底的案例调查和发现,我们开出了200份完整的处方。肌力分级评价治疗前后的改善情况。病例在1周内开始好转。肌力分级在治疗开始时为1级,在1个月内提高到3级。改善是渐进的,并且在1个月的时间内,患者开始在支持下行走。这显示了多肌炎的管理与顺势疗法药物土。
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引用次数: 0
Mesenteric Mesothelial Cyst Presented as Acute Abdominal Pain 肠系膜间皮囊肿表现为急性腹痛
2区 医学 Q1 PATHOLOGY Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000154
Jagtap SV
Mesenteric cysts are rare intra-abdominal tumors. The preoperative diagnosis of mesenteric cysts is challenging due to its rarity. We present a case of 65 -years-old female with history of progressive increasing abdominal discomfort and swelling she presented with sudden acute abdominal pain of 5 days. Physical examination revealed a mildly tender, palpable abdominal swelling occupying right iliac fossa measuring 10x8x3 cm. Plain and contrast computed tomography scan abdomen and pelvis showed an intra-abdominal well defined, thin walled cystic lesion in right iliac fossa and extending upto right hypochondriac region. It showed multiple thin internal septae and low level mobile internal echoes. On radio imaging suggestive of a mesenteric cyst was given and histopathological correlation was advised. The exploratory laprotomy with complete surgical excisions of cystic mass was done. The histopathological diagnosis of benign mesothelial cyst of mesentry was given. We are presenting rare case of simple mesenteric cyst for its clinical, radio imaging and histomorphological features.
肠系膜囊肿是一种罕见的腹内肿瘤。由于肠系膜囊肿的罕见性,其术前诊断具有挑战性。我们报告一位65岁女性,有进行性腹部不适和肿胀史,她表现为5天的突然急性腹痛。体格检查显示右髂窝有轻度压痛、可触及的腹部肿胀,大小为10x8x3 cm。腹部和骨盆ct平扫显示右侧髂窝腹内清晰薄壁囊性病变,并向上延伸至右侧疑病症区。可见多个薄的内隔和低水平移动的内回波。影像学提示为肠系膜囊肿,建议进行组织病理学检查。行探查性剖腹术并完全切除囊性肿块。对良性肠系膜间皮囊肿进行病理诊断。我们报告一例罕见的单纯性肠系膜囊肿的临床、影像学和组织形态学特征。
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引用次数: 0
Clinicopathologic Characterization of Double PIK3CA Mutated Advanced Breast Cancer: A Retrospective Cohort Study from a Single Institution 双PIK3CA突变晚期乳腺癌的临床病理特征:来自单一机构的回顾性队列研究
2区 医学 Q1 PATHOLOGY Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000155
Zhan H
Objectives: We aimed to characterize the clinicopathologic and molecular features of double PIK3CA mutated advanced breast cancer in a retrospective cohort study. Methods: This retrospective study included 196 advanced breast cancer patients who had the Oncomine next generation sequencing analysis. The clinicopathologic parameters were recorded for each individuals including age, tumor type, grade, ER, PR, HER2, and recurrence free survival. Results: PIK3CA mutations were detected in 77.5% (152/196) of advanced breast cancer patients, 129 (84.8%) of which contained single mutations, 20 (13.1%) of which contained double mutations, and 3 (2%) of which contained triple mutations. Double PIK3CA mutated tumors were mostly seen in postmenopausal women, had lower combined histologic grade, and were enriched in hormone receptor positive human epidermal growth factor receptor negative (HR+/HER2-) disease. Double PIK3CA mutations were more frequently associated with concurrent mutations of ESR1 (p=0.017) and ARID1A (p=0.054) compared to single PIK3CA mutations. No significant progression free survival differences were observed between PIK3CA mutated and wild-type groups and between double and single PIK3CA mutated groups when applied to all patients or HR+/ HER2- patients. Conclusion: Double PIK3CA mutated advanced breast cancer have similar clinicopathologic features as single mutated ones but demonstrate unique molecular features.
目的:我们旨在通过一项回顾性队列研究来描述双PIK3CA突变的晚期乳腺癌的临床病理和分子特征。方法:本回顾性研究纳入196例晚期乳腺癌患者进行Oncomine下一代测序分析。记录每位患者的临床病理参数,包括年龄、肿瘤类型、分级、ER、PR、HER2和无复发生存期。结果:77.5%(152/196)的晚期乳腺癌患者检出PIK3CA突变,其中单突变129例(84.8%),双突变20例(13.1%),三突变3例(2%)。双PIK3CA突变肿瘤多见于绝经后妇女,合并组织学分级较低,在激素受体阳性的人表皮生长因子受体阴性(HR+/HER2-)疾病中富集。与单PIK3CA突变相比,双PIK3CA突变更频繁地与ESR1 (p=0.017)和ARID1A (p=0.054)的并发突变相关。当应用于所有患者或HR+/ HER2-患者时,在PIK3CA突变组和野生型组之间以及双PIK3CA突变组和单PIK3CA突变组之间没有观察到显著的无进展生存差异。结论:PIK3CA双突变晚期乳腺癌与单突变晚期乳腺癌具有相似的临床病理特征,但具有独特的分子特征。
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引用次数: 0
Cyto-Architectural Complexity of Dyshormonogenic Goitre can Closely Mimic a Thyroid Follicular Malignancy: A Case Report and Review of the Literature to Avoid Diagnostic Pitfall 激素生成障碍甲状腺的细胞结构复杂性与甲状腺滤泡性恶性肿瘤非常相似:一个病例报告和文献回顾以避免诊断缺陷
2区 医学 Q1 PATHOLOGY Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000160
Nishat Afroz
A 13-year-old male child presented in the OPD with a midline 5x4cm thyroid swelling of 2 years duration with the chief complaint of difficulty in breathing. He also had growth and mental retardation since 3 years of age. His thyroid profile records revealed a severe degree of hypothyroidism and he was on thyroxine supplement since then. He underwent a right hemithyroidectomy for the right-sided nodular goitre causing on-and-off dyspnea. The gross specimen measured 5x4x3cm, which on cut section showed partially encapsulated multi-nodular solid areas. Microscopy yielded marked architectural complexity and prominent cellular and nuclear pleomorphism that mimicked a thyroid malignancy; for eg., a poorly differentiated papillary or follicular carcinoma. However, a thorough assessment of a range of histo-morphological features in the context of clinical history clinched the diagnosis of dyshormonogenetic goitre. One year postoperatively the patient is doing well on Thyroxine supplement. This case report reviews the literature about this rare benign entity of dyshormonogenetic goitre which closely mimics thyroid malignancy, notably a follicular malignancy on microscopy owing to its cytoarchitectural complexity and nuclear atypia. Hence, knowledge of its clinical presentation, gross and diverse microscopic features is extremely important to avoid misdiagnosis and thereby clinical management.
一名13岁男性儿童,因甲状腺中线5x4cm肿胀,持续2年,主诉为呼吸困难。他从3岁起就有发育迟缓和智力迟钝。他的甲状腺档案显示有严重的甲状腺功能减退,从那时起他一直在补充甲状腺素。他接受了右甲状腺切除术的右侧结节性甲状腺肿引起断断续续的呼吸困难。大体尺寸为5x4x3cm,切面显示部分包封的多结节实区。显微镜下发现了明显的结构复杂性和突出的细胞和核多形性,模仿甲状腺恶性肿瘤;如。一种低分化的乳头状或滤泡性癌。然而,在临床病史背景下的一系列组织形态学特征的全面评估确定了甲状腺肿的诊断。术后一年患者补充甲状腺素效果良好。本病例报告回顾了关于这种罕见的良性甲状腺肿的文献,它与甲状腺恶性肿瘤非常相似,特别是在显微镜下,由于其细胞结构的复杂性和核的非典型性,是一种滤泡恶性肿瘤。因此,了解其临床表现、大体和多种显微特征对于避免误诊和临床治疗至关重要。
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引用次数: 0
Comparative Analysis between Absolute Neutrophil Count and Absolute Monocyte Count as a Predictor of Haematopoietic Recovery in Patients with Acute Lymphoblastic Leukaemia 中性粒细胞绝对计数和单核细胞绝对计数作为急性淋巴细胞白血病患者造血恢复预测因子的比较分析
2区 医学 Q1 PATHOLOGY Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000159
Yesmin MS
Objectives: This study was aimed to find out the comparison between absolute neutrophil count and absolute monocyte count for haematopoietic recovery in acute lymphoblastic leukaemia (ALL) patients. Methods: In this study, a total of 50 patients of acute lymphoblastic leukaemia, aged between 8 months to 15 years were studied prospectively. Results: In the initial treatment phase (induction of remission phase), regularly increasing trends were seen in absolute neutrophil counts (ANC) prior to recovery of absolute monocyte counts (AMC). Of all the parameters, ANC recovered 1 day (≥0.5 x 109 /l) prior to recovery of AMC above (≥0.1 x 109 /l). Conclusion: ANC can be considered as an early predictor of haematopoietic recovery over AMC. These parameters can be used in conjunction with clinical conditions to decide about early discharge of leukaemia patients especially in developing countries where prolonged stay can result in hospital acquired infections.
目的:探讨急性淋巴细胞白血病(acute lymphoblastic leukemia, ALL)患者造血恢复过程中中性粒细胞绝对计数与单核细胞绝对计数的比较。方法:对50例年龄在8个月~ 15岁的急性淋巴细胞白血病患者进行前瞻性研究。结果:在初始治疗阶段(诱导缓解期),在绝对单核细胞计数(AMC)恢复之前,绝对中性粒细胞计数(ANC)有规律地增加趋势。在所有参数中,ANC比AMC(≥0.1 x 109 /l)恢复早1天(≥0.5 x 109 /l)。结论:ANC可作为AMC患者造血功能恢复的早期预测指标。这些参数可与临床条件结合使用,以决定白血病患者的早期出院,特别是在发展中国家,因为长期住院可能导致医院获得性感染。
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引用次数: 0
The Performance of the Thyroid Gland is Affected by the Intellectual and Psychological Pressures that College Students Endure During Exam Time 大学生在考试期间承受的智力和心理压力对甲状腺功能的影响
2区 医学 Q1 PATHOLOGY Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000162
Majid M Mahmood
The thyroid gland is affected by many factors, such as age, gender, and ethnicity. The gland is also influenced by metabolism, stress, and psychological state. In this clinical scenario, establishing a reference period for TSH, T3, and T4 is critical for the diagnosis of thyroid functional disorders before and after screening. The aim of this study is to assess the effect of mental stress on the levels of TSH, T3, and T4 before and after the exam. The study was conducted from December until the end of February 2022 at the Middle Technical College, University of Baghdad. 45 healthy young students, ranging in age from 19 to 23 years, were included in this study. The results found a significant difference between T4 levels in pre- and post-exam in males when compared with females, and there was also a difference between the levels of T3 and TSH in pre- and post-exam. Conclusion: Mental stress affects thyroid hormones by affecting the central regulation of TSH levels.
甲状腺受许多因素的影响,如年龄、性别和种族。腺体也受新陈代谢、压力和心理状态的影响。在这种临床情况下,建立TSH、T3和T4的参考期对于筛查前后甲状腺功能障碍的诊断至关重要。本研究的目的是评估心理压力对考试前后TSH、T3和T4水平的影响。该研究于2022年12月至2月底在巴格达大学中级技术学院进行,45名年龄在19至23岁之间的健康年轻学生参加了这项研究。结果发现,与女性相比,男性在检查前和检查后的T4水平有显著差异,T3和TSH水平在检查前和检查后也有差异。结论:精神应激通过影响中枢调节TSH水平影响甲状腺激素。
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引用次数: 0
A Rare Torsion Case of Polycystic Ovarian Syndrome: A Natural Course with Laparoscopic, Cytological and Pathological Findings 一例罕见的多囊卵巢综合征扭转:腹腔镜、细胞学和病理结果的自然过程
2区 医学 Q1 PATHOLOGY Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000157
Kenji Niwa
Polycystic ovary (PCO) syndrome cases with adnexal torsion in a natural cycle without ovarian induction are rare, and many torsion cases in PCOs involve pelvic masses, such as uterine fibroids. A 37-year-old woman, gravida two para two, came in an emergency because of lower abdominal pain for 2 or 3 days. PCO was followed in a previous hospital. At a visit in her Douglas pouch, a 7.3 x 4.5 cm mass that was consistent with the point of tenderness was detected by ultrasonography and magnetic resonance images. The patient underwent a semi-emergent laparoscopic surgery for a diagnosis of torsion of the left adnexa. At an abdominal exploration, the left ovary was swollen to approximate 7 cm in size and twisted 360°clockwise. The intraoperative imprint cytology showed the presence of fibrous cells alone, thus the malignancy denied. Histologically, fibrously thickened cortex and multiple follicular cysts due to atretic follicles were found, compatible with PCO. As the patient did not desire to have children and less likely to twist the right ovary, she wanted having low dose pills.
多囊卵巢(PCO)综合征在无卵巢诱导的自然周期中伴有附件扭转的病例是罕见的,许多PCOs的扭转病例涉及盆腔肿块,如子宫肌瘤。一名37岁妇女,妊娠2、2段,因下腹疼痛2、3天而急诊就诊。在以前的一家医院进行了PCO随访。在她的道格拉斯育儿袋就诊时,超声和磁共振图像检测到一个7.3 x 4.5 cm的肿块,与压痛点一致。患者接受了半紧急腹腔镜手术,诊断为左附件扭转。腹部探查,左侧卵巢肿大约7cm,顺时针旋转360°。术中印迹细胞学显示仅存在纤维细胞,因此否认恶性肿瘤。组织学上,发现纤维性增厚的皮质和因卵泡闭锁引起的多个滤泡囊肿,与PCO相符。由于患者不想要孩子,也不太可能扭曲右卵巢,她希望服用低剂量的药物。
{"title":"A Rare Torsion Case of Polycystic Ovarian Syndrome: A Natural Course with Laparoscopic, Cytological and Pathological Findings","authors":"Kenji Niwa","doi":"10.23880/cprj-16000157","DOIUrl":"https://doi.org/10.23880/cprj-16000157","url":null,"abstract":"Polycystic ovary (PCO) syndrome cases with adnexal torsion in a natural cycle without ovarian induction are rare, and many torsion cases in PCOs involve pelvic masses, such as uterine fibroids. A 37-year-old woman, gravida two para two, came in an emergency because of lower abdominal pain for 2 or 3 days. PCO was followed in a previous hospital. At a visit in her Douglas pouch, a 7.3 x 4.5 cm mass that was consistent with the point of tenderness was detected by ultrasonography and magnetic resonance images. The patient underwent a semi-emergent laparoscopic surgery for a diagnosis of torsion of the left adnexa. At an abdominal exploration, the left ovary was swollen to approximate 7 cm in size and twisted 360°clockwise. The intraoperative imprint cytology showed the presence of fibrous cells alone, thus the malignancy denied. Histologically, fibrously thickened cortex and multiple follicular cysts due to atretic follicles were found, compatible with PCO. As the patient did not desire to have children and less likely to twist the right ovary, she wanted having low dose pills.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135551010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ectopic Pregnancy in the Cervix-A Case Report with Review of Literature 宫颈异位妊娠1例报告并文献复习
2区 医学 Q1 PATHOLOGY Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000161
Pranjal Shah
Cervical ectopic pregnancy is a rare type of ectopic pregnancy with an evidence of less than 0.1% of all ectopic pregnancies. It is associated with high morbidity and mortality and may lead to massive hemorrhage, which may require hysterectomy to save the patient. We report a case of ectopic pregnancy in cervix in a 27-year-old female patient with a previous history of lower segment caesarean section (LSCS). The current pregnancy was complicated with a massive hemorrhage, hence leading to hysterectomy
宫颈异位妊娠是一种罕见的异位妊娠类型,其发生率低于所有异位妊娠的0.1%。它与高发病率和死亡率相关,并可能导致大出血,这可能需要子宫切除术来挽救患者。我们报告一例宫颈异位妊娠的27岁女性患者与既往的历史下段剖宫产(LSCS)。目前的怀孕是复杂的大出血,因此导致子宫切除术
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引用次数: 0
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Journal of Pathology Clinical Research
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