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Diagnostic and Interventional Imaging最新文献

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Idiopathic intracranial hypertension: A complex condition in which physiological and anatomical concepts collide. 特发性颅内高压:生理学和解剖学概念相互碰撞的复杂病症。
IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-02 DOI: 10.1016/j.diii.2024.06.009
Lotfi Hacein-Bey
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引用次数: 0
When artificial intelligence meets photon-counting coronary CT angiography to reduce the need for invasive coronary angiography in TAVR candidates 当人工智能遇上光子计数冠状动脉 CT 血管造影术,可减少 TAVR 候选者对侵入性冠状动脉造影术的需求。
IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.diii.2024.02.007
Farah Cadour, Jean-Nicolas Dacher
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引用次数: 0
4D flow cardiac MRI to assess pulmonary blood flow in patients with pulmonary arterial hypertension associated with congenital heart disease 4D 流式心脏磁共振成像评估先天性心脏病肺动脉高压患者的肺血流。
IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.diii.2024.01.009
Estibaliz Valdeolmillos , Hichem Sakhi , Marine Tortigue , Marion Audié , Marc-Antoine Isorni , Florence Lecerf , Olivier Sitbon , David Montani , Xavier Jais , Laurent Savale , Marc Humbert , Arshid Azarine , Sébastien Hascoët

Purpose

The purpose of this study was to evaluate the accuracy of four-dimensional flow cardiac magnetic resonance imaging (4D flow MRI) compared to right heart catheterization in measuring pulmonary flow (Qp), systemic flow (Qs) and pulmonary-to-systemic flow ratio (Qp/Qs) in patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD).

Materials and methods

The study was registered on Clinical-trial.gov (NCT03928002). Sixty-four patients with PAH-CHD who underwent 4D flow MRI were included. There were 16 men and 48 women with a mean age of 45.3 ± 13.7 (standard deviation [SD]) years (age range: 21–77 years). Fifty patients (50/64; 78%) presented with pre-tricuspid shunt. Qp (L/min), Qs (L/min) and Qp/Qs were measured invasively using direct Fick method during right heart catheterization and compared with measurements assessed by 4D flow MRI within a 24–48-hour window.

Results

The average mean pulmonary artery pressure was 51 ± 17 (SD) mm Hg with median pulmonary vascular resistance of 8.8 Wood units (Q1, Q3: 5.3, 11.7). A strong linear correlation was found between Qp measurements obtained with 4D flow MRI and those obtained with the Fick method (r = 0.96; P < 0.001). Bland Altman analysis indicated a mean difference of 0.15 ± 0.48 (SD) L/min between Qp estimated by 4D flow MRI and by right heart catheterization. A strong correlation was found between Qs and Qp/Qs measured by 4D flow MRI and those obtained with the direct Fick method (r = 0.85 and r = 0.92; P < 0.001 for both).

Conclusion

Qp as measured by 4D flow MRI shows a strong correlation with measurements derived from the direct Fick method. Further investigation is needed to develop less complex and standardized methods for measuring essential PAH parameters, such as pulmonary arterial pressures and pulmonary vascular resistance.

目的:本研究旨在评估四维血流心脏磁共振成像(4D flow MRI)与右心导管检查相比,在测量肺动脉高压伴先天性心脏病(PAH-CHD)患者的肺血流(Qp)、全身血流(Qs)和肺-全身血流比(Qp/Qs)方面的准确性:该研究已在 Clinical-trial.gov (NCT03928002) 上注册。研究纳入了 64 名接受 4D 血流 MRI 检查的 PAH-CHD 患者。其中男性 16 人,女性 48 人,平均年龄为 45.3 ± 13.7(标准差 [SD])岁(年龄范围:21-77 岁)。50名患者(50/64;78%)出现三尖瓣前分流。在右心导管检查过程中采用直接费克法对 Qp(升/分)、Qs(升/分)和 Qp/Qs 进行了有创测量,并与 24-48 小时内通过四维血流磁共振成像评估的测量结果进行了比较:平均肺动脉压为 51 ± 17 (SD) mm Hg,中位肺血管阻力为 8.8 Wood 单位(Q1, Q3: 5.3, 11.7)。四维血流磁共振成像获得的 Qp 测量值与菲克法获得的 Qp 测量值之间存在很强的线性相关(r = 0.96;P < 0.001)。Bland Altman 分析表明,四维血流磁共振成像和右心导管检查估测的 Qp 平均相差 0.15 ± 0.48 (SD) 升/分钟。四维血流磁共振成像测量的 Qs 和 Qp/Qs 与直接 Fick 法测量的 Qs 和 Qp/Qs 之间存在很强的相关性(r = 0.85 和 r = 0.92;两者的 P < 0.001):结论:四维血流磁共振成像测得的 Qp 与直接菲克法测得的结果有很强的相关性。需要进一步研究,开发出不那么复杂且标准化的方法来测量 PAH 重要参数,如肺动脉压和肺血管阻力。
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引用次数: 0
More evidence to support greater use of 4D flow cardiac MRI 更多证据支持更广泛地使用 4D 流式心脏 MRI。
IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.diii.2024.02.014
David A Bluemke , Nadine Kawel-Boehm
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引用次数: 0
Improved image quality and abdominal lesion detection with photon-counting CT compared to dual-source CT: New evidence from a phantom study. 与双源 CT 相比,光子计数 CT 提高了图像质量和腹部病灶检测能力:一项模型研究提供的新证据。
IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.diii.2024.06.008
Francesco Macri
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引用次数: 0
Dual-energy CT: Bridging the gap between innovation and clinical practice 双能 CT:弥合创新与临床实践之间的差距。
IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.diii.2024.02.011
Paul Calame , Sébastien Mulé
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引用次数: 0
The potential and pitfalls of ChatGPT in radiology ChatGPT 在放射学中的潜力和隐患。
IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.diii.2024.05.003
Augustin Lecler , Philippe Soyer , Bo Gong
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引用次数: 0
Coronary artery disease evaluation during transcatheter aortic valve replacement work-up using photon-counting CT and artificial intelligence 使用光子计数 CT 和人工智能在经导管主动脉瓣置换术检查过程中评估冠状动脉疾病。
IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.diii.2024.01.010
Jan M. Brendel , Jonathan Walterspiel , Florian Hagen , Jens Kübler , Jean-François Paul , Konstantin Nikolaou , Meinrad Gawaz , Simon Greulich , Patrick Krumm , Moritz Winkelmann

Purpose

The purpose of this study was to evaluate the capabilities of photon-counting (PC) CT combined with artificial intelligence-derived coronary computed tomography angiography (PC-CCTA) stenosis quantification and fractional flow reserve prediction (FFRai) for the assessment of coronary artery disease (CAD) in transcatheter aortic valve replacement (TAVR) work-up.

Materials and methods

Consecutive patients with severe symptomatic aortic valve stenosis referred for pre-TAVR work-up between October 2021 and June 2023 were included in this retrospective tertiary single-center study. All patients underwent both PC-CCTA and ICA within three months for reference standard diagnosis. PC-CCTA stenosis quantification (at 50% level) and FFRai (at 0.8 level) were predicted using two deep learning models (CorEx, Spimed-AI). Diagnostic performance for global CAD evaluation (at least one significant stenosis ≥ 50% or FFRai ≤ 0.8) was assessed.

Results

A total of 260 patients (138 men, 122 women) with a mean age of 78.7 ± 8.1 (standard deviation) years (age range: 51–93 years) were evaluated. Significant CAD on ICA was present in 126/260 patients (48.5%). Per-patient sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 96.0% (95% confidence interval [CI]: 91.0–98.7), 68.7% (95% CI: 60.1–76.4), 74.3 % (95% CI: 69.1–78.8), 94.8% (95% CI: 88.5–97.8), and 81.9% (95% CI: 76.7–86.4) for PC-CCTA, and 96.8% (95% CI: 92.1–99.1), 87.3% (95% CI: 80.5–92.4), 87.8% (95% CI: 82.2–91.8), 96.7% (95% CI: 91.7–98.7), and 91.9% (95% CI: 87.9–94.9) for FFRai. Area under the curve of FFRai was 0.92 (95% CI: 0.88–0.95) compared to 0.82 for PC-CCTA (95% CI: 0.77–0.87) (P < 0.001). FFRai-guidance could have prevented the need for ICA in 121 out of 260 patients (46.5%) vs. 97 out of 260 (37.3%) using PC-CCTA alone (P < 0.001).

Conclusion

Deep learning-based photon-counting FFRai evaluation improves the accuracy of PC-CCTA ≥ 50% stenosis detection, reduces the need for ICA, and may be incorporated into the clinical TAVR work-up for the assessment of CAD.

目的:本研究旨在评估光子计数(PC)CT 联合人工智能冠状动脉计算机断层扫描(PC-CCTA)狭窄量化和分数血流储备预测(FFRai)在经导管主动脉瓣置换术(TAVR)检查中评估冠状动脉疾病(CAD)的能力:这项回顾性三级单中心研究纳入了2021年10月至2023年6月期间转诊进行TAVR术前检查的连续重症主动脉瓣狭窄患者。所有患者均在三个月内接受了 PC-CCTA 和 ICA 诊断,以作为参考标准。PC-CCTA 狭窄量化(50% 水平)和 FFRai(0.8 水平)通过两个深度学习模型(CorEx、Spimed-AI)进行预测。结果:共评估了 260 名患者(138 名男性,122 名女性),平均年龄为 78.7 ± 8.1(标准差)岁(年龄范围:51-93 岁)。126/260例患者(48.5%)的ICA显示存在明显的CAD。每位患者的敏感性、特异性、阳性预测值、阴性预测值和诊断准确性分别为 96.0%(95% 置信区间 [CI]:91.0-98.7)、68.7%(95% 置信区间:60.1-76.4)、74.3%(95% 置信区间:69.1-78.8)、94.8%(95% 置信区间:60.1-76.4)、74.3%(95% 置信区间:69.1-78.8)、74.3%(95% 置信区间:69.1-78.8FFRai的曲线下面积分别为96.8%(95% CI:92.1-99.1)、87.3%(95% CI:80.5-92.4)、87.8%(95% CI:82.2-91.8)、96.7%(95% CI:91.7-98.7)和91.9%(95% CI:87.9-94.9)。FFRai 的曲线下面积为 0.92(95% CI:0.88-0.95),而 PC-CCTA 为 0.82(95% CI:0.77-0.87)(P < 0.001)。在FFRai指导下,260名患者中有121名(46.5%)无需进行ICA,而仅使用PC-CCTA的260名患者中有97名(37.3%)无需进行ICA(P < 0.001):结论:基于深度学习的光子计数 FFRai 评估提高了 PC-CCTA ≥ 50% 狭窄检测的准确性,减少了 ICA 的需求,可纳入临床 TAVR 工作检查以评估 CAD。
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引用次数: 0
Intracerebral hemodynamic abnormalities in patients with Parkinson's disease: Comparison between multi-delay arterial spin labelling and conventional single-delay arterial spin labelling 帕金森病患者的脑内血流动力学异常:多延迟动脉自旋标记与传统单延迟动脉自旋标记的比较
IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.diii.2024.01.006
Xue Wang , Lijuan Wang , Yating Wu , Xiang Lv , Yao Xu , Weiqiang Dou , Hongying Zhang , Jingtao Wu , Song'an Shang

Purpose

The purpose of this study was to analyze the intracerebral abnormalities of hemodynamics in patients with Parkinson's disease (PD) through arterial spin labelling (ASL) technique with multi-delay ASL (MDASL) and conventional single-delay ASL (SDASL) protocols and to verify the potential clinical application of these features for the diagnosis of PD.

Materials and methods

Perfusion data of the brain obtained using MDASL and SDASL in patients with PD were compared to those obtained in healthy control (HC) subjects. Intergroup comparisons of z-scored cerebral blood flow (zCBF), arterial transit time (zATT) and cerebral blood volume (zCBV) were performed via voxel-based analysis. Performance of these perfusion metrics were estimated using area under the receiver operating characteristic curve (AUC) and compared using Delong test.

Results

A total of 47 patients with PD (29 men; 18 women; mean age, 69.0 ± 7.6 (standard deviation, [SD]) years; range: 50.0−84.0 years) and 50 HC subjects (28 men; 22 women; mean age, 70.1 ± 6.2 [SD] years; range: 50.0−93.0 years) were included. Relative to the uncorrected-zCBF map, the corrected-zCBF map further refined the distributed brain regions in the PD group versus the HC group, manifested as the extension of motor-related regions (PFWE < 0.001). Compared to the HC subjects, patients with PD had elevated zATT and zCBV in the right putamen, a shortened zATT in the superior frontal gyrus, and specific zCBV variations in the left precuneus and the right supplementary motor area (PFWE < 0.001). The corrected-zCBF (AUC, 0.90; 95% confidence interval [CI]: 0.84−0.96) showed better classification performance than uncorrected-zCBF (AUC, 0.84; 95% CI: 0.75−0.92) (P = 0.035). zCBV achieved an AUC of 0.89 (95% CI: 0.82−0.96) and zATT achieved an AUC of 0.66 (95% CI: 0.55−0.77). The integration model of hemodynamic features from MDASL provided improved performance (AUC, 0.97; 95% CI: 0.95−0.98) for the diagnosis of PD by comparison with each perfusion model (P < 0.001).

Conclusion

ASL identifies impaired hemodynamics in patients with PD including regional abnormalities of CBF, CBV and ATT, which can better be mapped with MDASL compared to SDASL. These findings provide complementary depictions of perfusion abnormalities in patients with PD and highlight the clinical feasibility of MDASL.

本研究旨在通过动脉自旋标记(ASL)技术,采用多延迟ASL(MDASL)和传统单延迟ASL(SDASL)方案,分析帕金森病(PD)患者脑内血流动力学的异常,并验证这些特征在帕金森病诊断中的潜在临床应用。材料和方法将使用MDASL和SDASL获得的帕金森病患者脑灌注数据与健康对照(HC)受试者的脑灌注数据进行比较。通过基于体素的分析对z评分脑血流(zCBF)、动脉转运时间(zATT)和脑血容量(zCBV)进行组间比较。使用接收者操作特征曲线下面积(AUC)估算这些灌注指标的性能,并使用德隆检验进行比较:其中包括 47 名帕金森病患者(29 名男性;18 名女性;平均年龄为 69.0 ± 7.6(标准差)岁;年龄范围为 50.0-84.0 岁)和 50 名 HC 受试者(28 名男性;22 名女性;平均年龄为 70.1 ± 6.2 [SD] 岁;年龄范围为 50.0-93.0 岁)。相对于未校正-zCBF图,校正-zCBF图进一步完善了PD组与HC组的脑区分布,表现为运动相关区域的扩展(PFWE < 0.001)。与 HC 受试者相比,PD 患者的右侧丘脑的 zATT 和 zCBV 升高,额上回的 zATT 缩短,左侧楔前区和右侧辅助运动区有特定的 zCBV 变化(PFWE < 0.001)。校正后的 zCBF(AUC,0.90;95% 置信区间 [CI]:0.84-0.96)比未校正的 zCBF(AUC,0.84;95% 置信区间:0.75-0.92)显示出更好的分类性能(P = 0.035)。zCBV的AUC为0.89(95% CI:0.82-0.96),zATT的AUC为0.66(95% CI:0.55-0.77)。与每个灌注模型相比,MDASL 的血液动力学特征整合模型在诊断帕金森病方面的性能有所提高(AUC,0.97;95% CI:0.95-0.98)(P <;0.001)。这些发现为帕金森病患者的灌注异常提供了补充描述,并突出了 MDASL 的临床可行性。
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引用次数: 0
Incremental diagnostic value of virtual non-contrast dual-energy CT for the diagnosis of choledocholithiasis over conventional unenhanced CT 虚拟非对比双能 CT 对胆总管结石诊断的增量诊断价值优于传统未增强 CT。
IF 4.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.diii.2024.02.004
Chang-Hui Xiao , Peng Liu , Hui-Hui Zhang , Fan Yang , Xiang Chen , Feng Huang , Jian-bin Liu , Xian-Zheng Tan

Purpose

The purpose of this study was to evaluate the incremental diagnostic value of virtual non-contrast (VNC) images derived from unenhanced dual-energy computed tomography (CT) for the diagnosis of choledocholithiasis by comparison with conventional unenhanced CT.

Materials and methods

Eighty-nine patients with gallbladder stones who had undergone both abdominal unenhanced dual-energy CT and magnetic resonance cholangiopancreatography (MRCP) were retrospectively included. There were 53 men and 36 women, with a mean age of 54 ± 13 (standard deviation) years (age range: 41–67 years). VNC and conventional CT images were generated. Two independent radiologists evaluated the presence of choledocholithiasis in three reading sessions (session 1, conventional unenhanced CT images; session 2, VNC images; session 3, conventional unenhanced CT plus VNC images). The reading time to identify choledocholithiasis was recorded. Inter-reader agreement was measured by using the Cohen kappa (κ) test. Incremental diagnostic value of VNC imaging when combined with conventional unenhanced CT was assessed based on discrimination (area under the curve [AUC]) and clinical utility (decision curve analysis). The diagnostic performance of dual-energy CT and that of MRCP were compared using DeLong test.

Results

Using the standard of reference, 39 patients (39/89; 44%) had choledocholithiasis. The diagnosis of choledocholithiasis was improved using VNC images in combination with conventional unenhanced CT (AUC, 0.877; 95% confidence interval [CI]: 0.808, 0.947) by comparison with conventional unenhanced CT alone (AUC, 0.789; 95% CI: 0.718, 0.877) (P = 0.033) and achieved almost perfect inter-reader agreement (κ = 0.88; 95% CI: 0.72, 1.00) for the diagnosis of choledocholithiasis, without lengthening the median reading time (16.2 s for the combination of conventional CT and VNC images vs. 14.7 s for conventional CT alone; P = 0.325). Based on decision curve analysis, adding VNC imaging to conventional unenhanced CT resulted in a higher net benefit among most of decision thresholds. No differences in diagnostic performance were found between the combination of conventional unenhanced CT and VNC imaging (AUC, 0.877; 95% CI: 0.808, 0.947) and MRCP (AUC, 0.913; 95% CI: 0.852, 0.974) (P = 0.458).

Conclusions

VNC images derived from dual-energy unenhanced CT have incremental diagnostic value for the diagnosis of choledocholithiasis. Unenhanced CT in a dual-energy mode may be a useful tool for the diagnosis of choledocholithiasis.

目的:本研究的目的是通过与传统的未增强 CT 相比,评估未增强双能计算机断层扫描(CT)产生的虚拟非对比(VNC)图像在诊断胆总管结石方面的增量诊断价值:回顾性纳入了 89 名同时接受过腹部未增强双能 CT 和磁共振胆胰管造影术(MRCP)检查的胆囊结石患者。其中男性 53 人,女性 36 人,平均年龄为 54 ± 13(标准差)岁(年龄范围:41-67 岁)。生成了 VNC 和常规 CT 图像。两名独立的放射科医生分三次阅片评估是否存在胆总管结石(第一次阅片,常规未增强 CT 图像;第二次阅片,VNC 图像;第三次阅片,常规未增强 CT 加 VNC 图像)。记录识别胆总管结石的阅片时间。使用科恩卡帕(κ)检验来衡量阅片者之间的一致性。根据辨别率(曲线下面积 [AUC])和临床效用(决策曲线分析)评估了 VNC 成像与传统未增强 CT 结合使用时的增量诊断价值。使用 DeLong 检验比较了双能 CT 和 MRCP 的诊断性能:采用参考标准,39 名患者(39/89;44%)患有胆总管结石。与单独使用常规未增强 CT(AUC,0.789;95% CI:0.718,0.877)相比,VNC 图像与常规未增强 CT 结合使用可提高胆总管结石的诊断率(AUC,0.877;95% 置信区间 [CI]:0.808,0.947)(P = 0.033),并在诊断胆总管结石方面实现了几乎完美的阅片者间一致性(κ = 0.88; 95% CI: 0.72, 1.00),而没有延长中位阅片时间(常规 CT 和 VNC 图像组合为 16.2 秒,常规 CT 单独为 14.7 秒;P= 0.325)。根据决策曲线分析,在常规未增强 CT 的基础上增加 VNC 成像可在大多数决策阈值中获得更高的净收益。传统未增强 CT 与 VNC 成像(AUC,0.877;95% CI:0.808,0.947)和 MRCP(AUC,0.913;95% CI:0.852,0.974)的组合在诊断性能上没有差异(P= 0.458):结论:双能量未增强 CT 导出的 VNC 图像对胆总管结石的诊断具有增量诊断价值。双能量模式下的未增强 CT 可能是诊断胆总管结石的有用工具。
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引用次数: 0
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Diagnostic and Interventional Imaging
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