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Diagnostic and Interventional Imaging最新文献

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Clarifying the role of dual-energy CT in the diagnosis of radiolucent gallstone of the common bile duct 明确双能CT在胆总管透光性胆结石诊断中的作用。
IF 8.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-01-01 DOI: 10.1016/j.diii.2025.10.008
Paul Calame, Loic Demir, Romain Moinet, Marine Julien, Eric Delabrousse
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引用次数: 0
Beyond algorithms: How agent-based artificial intelligence is changing the future of radiology 超越算法:基于代理的人工智能如何改变放射学的未来。
IF 8.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-01-01 DOI: 10.1016/j.diii.2025.11.009
Jules Grégory , Laure Fournier , Bo Gong , Augustin Lecler
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引用次数: 0
Transarterial radioembolization versus atezolizumab-bevacizumab for the treatment of hepatocellular carcinoma with portal vein tumor thrombosis 经动脉放射栓塞与阿特唑单抗-贝伐单抗治疗肝癌合并门静脉肿瘤血栓的比较
IF 8.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-01-01 DOI: 10.1016/j.diii.2025.09.002
Youngsu Park , Yuri Cho , Seung Up Kim , Aryoung Kim , Hyunjae Shin , Hyo-Cheol Kim , In Joon Lee , Gyoung Min Kim , Dongho Hyun , Yunmi Ko , Jeayeon Park , Jae Woong Yoon , Gyung Sun Lim , Moon Haeng Hur , Yun Bin Lee , Eun Ju Cho , Jeong-Hoon Lee , Su Jong Yu , Jung-Hwan Yoon , Jin Wook Chung , Yoon Jun Kim

Purpose

The purpose of this study was to compare transarterial radioembolization (TARE) and atezolizumab plus bevacizumab (Atezo/Bev) in treatment-naïve patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT) without extrahepatic metastasis.

Material and methods

This multicenter retrospective study evaluated 213 patients initially treated with TARE or Atezo/Bev between 2016 and 2023. The primary outcome was overall survival, and the secondary outcomes were progression-free survival, objective response rate, and safety. Baseline characteristics were adjusted using inverse probability treatment weighting or propensity score matching.

Results

Deaths occurred in 36 out of 125 patients (28.8 %) in the TARE group and 57 out of 88 patients (64.8 %) in the Atezo/Bev group. The median overall survival was significantly longer in the TARE group (27.5 months) than in the Atezo/Bev group (8.6 months) (P < 0.01), consistent across analyses before matching (hazard ratio [HR], 0.38; 95% confidence interval [CI]: 0.25–0.58; P < 0.01), after inverse probability treatment weighting (HR, 0.49; 95 % CI: 0.28–0.85; P = 0.01), and after propensity score matching (HR, 0.40; 95% CI: 0.22–0.74; P < 0.01). In the PVTT subgroup involving segmental to lobar branches (Vp1–3), TARE demonstrated prolonged overall survival (HR, 0.36; 95 % CI: 0.20–0.63; P < 0.01), with no significant difference in patients with Vp4. The TARE and Atezo/Bev groups exhibited similar progression-free survival. No significant differences in objective response rate were found between TARE group (22.2–30.9 %) and Atezo/Bev group (30.6–30.9 %). Adverse events were less frequent in the TARE group than in the Atezo/Bev group. The incidence of grade ≥ 2 ascites and variceal bleeding were significantly lower in the TARE group (12.0 % and 1.7 %, respectively) than in the Atezo/Bev group (20.5 % and 8 %, respectively) (both P < 0.05). No significant differences in Child–Pugh score aggravation of ≥ 2 were observed between the TARE group (14.4 %) and the Atezo/Bev group (25 %) (P = 0.08).

Conclusion

For patients with preserved liver function and locally advanced HCC involving segmental or lobar PVTT, TARE may be preferable to Atezo/Bev.
目的:本研究的目的是比较经动脉放射栓塞(TARE)和atezolizumab加贝伐单抗(Atezo/Bev)治疗treatment-naïve无肝外转移的肝细胞癌(HCC)和门静脉肿瘤血栓形成(PVTT)患者。材料和方法:这项多中心回顾性研究评估了2016年至2023年间最初接受TARE或Atezo/Bev治疗的213例患者。主要终点是总生存期,次要终点是无进展生存期、客观有效率和安全性。基线特征采用逆概率处理加权或倾向评分匹配进行调整。结果:TARE组125例患者中有36例(28.8%)死亡,Atezo/Bev组88例患者中有57例(64.8%)死亡。TARE组的中位总生存期(27.5个月)显著高于Atezo/Bev组(8.6个月)(P < 0.01),在配对前(风险比[HR]为0.38,95%可信区间[CI]为0.25-0.58,P < 0.01)、反概率加权治疗后(HR为0.49,95% CI为0.28-0.85,P = 0.01)和倾向评分匹配后(HR为0.40,95% CI为0.22-0.74,P < 0.01)的分析结果一致。在涉及节段至大叶分支(Vp1-3)的PVTT亚组中,TARE表现出延长的总生存期(HR, 0.36; 95% CI: 0.20-0.63; P < 0.01), Vp4患者无显著差异。TARE组和Atezo/Bev组表现出相似的无进展生存率。TARE组(22.2- 30.9%)与Atezo/Bev组(30.6- 30.9%)的客观有效率无显著差异。TARE组的不良事件发生率低于Atezo/Bev组。TARE组≥2级腹水和静脉曲张出血发生率(分别为12.0%和1.7%)显著低于Atezo/Bev组(分别为20.5%和8%)(均P < 0.05)。TARE组(14.4%)与Atezo/Bev组(25%)Child-Pugh评分加重≥2的差异无统计学意义(P = 0.08)。结论:对于保留肝功能和局部晚期肝癌合并节段性或大叶性PVTT的患者,TARE可能优于Atezo/Bev。
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引用次数: 0
Agentic systems in radiology: Principles, opportunities, privacy risks, regulation, and sustainability concerns 放射学中的代理系统:原则、机会、隐私风险、监管和可持续性问题。
IF 8.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-01-01 DOI: 10.1016/j.diii.2025.10.002
Eleftherios Tzanis , Lisa C. Adams , Tugba Akinci D’Antonoli , Keno K. Bressem , Renato Cuocolo , Burak Kocak , Christina Malamateniou , Michail E. Klontzas
The rapid rise of transformer-based large language models (LLMs) has introduced new opportunities for automation and decision support in radiology, particularly in applications such as report generation, protocol optimization, and structured interpretation. Despite their impressive performance in producing contextually coherent text, conventional LLMs remain limited by their inability to interact autonomously with external systems, retrieve data, or execute code, restricting their role in real-world clinical and research workflows. To address these limitations, agentic systems have emerged as a new paradigm. By embedding LLMs within frameworks that enable reasoning, planning, and action, agentic systems extend LLM capabilities to dynamic interaction with users, tools, and data sources. This review provides a comprehensive overview of the foundations, architectures, and operational mechanisms of agentic systems, focusing on their applications in medical imaging and radiology. It summarizes key developments in the literature, including recent multi-agent frameworks for automated radiomics pipelines, and discusses the potential benefits of these systems in enhancing the reproducibility, interpretability, and accessibility of AI-driven workflows. The review critically examines current regulatory considerations, ethical implications, and sustainability challenges to highlight essential gaps that must be addressed for the safe and responsible clinical integration of these systems.
基于变压器的大型语言模型(llm)的快速崛起为放射学中的自动化和决策支持带来了新的机会,特别是在报告生成、协议优化和结构化解释等应用中。尽管传统法学硕士在生成上下文连贯的文本方面表现出色,但它们仍然受到无法与外部系统自主交互、检索数据或执行代码的限制,这限制了它们在现实世界的临床和研究工作流程中的作用。为了解决这些限制,代理系统作为一种新的范例出现了。通过将LLM嵌入到能够推理、规划和行动的框架中,代理系统将LLM的功能扩展到与用户、工具和数据源的动态交互。本文综述了代理系统的基础、结构和运行机制,重点介绍了代理系统在医学成像和放射学中的应用。它总结了文献中的关键发展,包括自动化放射组学管道的最新多代理框架,并讨论了这些系统在增强人工智能驱动工作流程的可重复性、可解释性和可访问性方面的潜在好处。这篇综述严格审查了当前的监管考虑、伦理影响和可持续性挑战,以突出必须解决的基本差距,以实现这些系统的安全和负责任的临床整合。
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引用次数: 0
Understanding the challenges to implementing AI solutions in radiology departments and how to overcome them: A comprehensive review endorsed by the French College of Radiologists (CERF) and the French Society of Radiology (SFR). 了解在放射科实施人工智能解决方案所面临的挑战以及如何克服这些挑战:法国放射科医师学院(CERF)和法国放射学会(SFR)批准的一项全面审查。
IF 8.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-12-22 DOI: 10.1016/j.diii.2025.12.002
Amandine Crombé, Camille Bourillon, Stéphane Chaillou, Clara Bechet, Jules Dupont, Alexandre Bône, Fanny Louvet-de Verchère, Alain Luciani, Marie-France Bellin, Christophe Aubé, Nathalie Lassau

Despite the exponential growth of artificial intelligence (AI) solutions designed to assist radiologists in clinical practice, their actual impact on radiology departments remains below initial expectations. Daily workflows have not been profoundly transformed. The actual clinical benefit of these tools is often limited to single, modality-specific "narrow AI" tasks, and their return on investment is unclear. The purpose of this article was to analyze: (i), the human and perceptual challenges that shape attitudes toward AI among radiologists, referring clinicians, and patients; (ii), the technical and clinical limitations of current AI models, including the mismatches between target tasks and real-world needs, and between published versus real-life performances; (iii), the lack of objective return on investment quantification and the paucity of medicoeconomic studies in a context of constrained hospital budgets; (iv), the limitations of the current "assistive models" of human-AI interaction in radiology; (v), the technical and organizational difficulties that information and technology departments face in integrating, maintaining, and securing a growing number of AI applications across specialties within complex hospital information systems; (vi), the ethical and patient safety concerns related to bias, transparency, data protection, and regulatory compliance with respect to data protection officers and the European General Data Protection Regulation; and (vii), the underexplored environmental and energy implications of large-scale AI deployment. Finally, potential solutions relating to AI governance, national data infrastructures, user education, and the design of randomized clinical trials and cost-effectiveness studies, are discussed to promote the responsible, evidence-based integration of AI into radiology practice.

尽管旨在协助放射科医生临床实践的人工智能(AI)解决方案呈指数级增长,但它们对放射科的实际影响仍低于最初的预期。日常工作流程并没有发生深刻的变化。这些工具的实际临床效益通常局限于单一的、特定模式的“狭义人工智能”任务,其投资回报尚不清楚。本文的目的是分析:(i)影响放射科医生、转诊临床医生和患者对人工智能态度的人类和感知挑战;(ii)当前人工智能模型的技术和临床局限性,包括目标任务与现实世界需求之间的不匹配,以及公布的与现实生活中的表现之间的不匹配;(三)在医院预算有限的情况下,缺乏客观的投资回报量化和缺乏医学经济学研究;(iv)当前放射学中人机交互“辅助模型”的局限性;(v)信息和技术部门在复杂的医院信息系统中集成、维护和保护越来越多的跨专业人工智能应用时面临的技术和组织困难;(vi)与数据保护官和《欧洲通用数据保护条例》相关的偏见、透明度、数据保护和监管合规方面的道德和患者安全问题;(vii)大规模人工智能部署对环境和能源的影响尚未得到充分探讨。最后,讨论了与人工智能治理、国家数据基础设施、用户教育、随机临床试验设计和成本效益研究相关的潜在解决方案,以促进负责任的、以证据为基础的人工智能融入放射学实践。
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引用次数: 0
Automatic vessel tracking with MRI-cone-beam CT image fusion for venous embolization in pelvic congestion syndrome. 磁共振锥束CT图像融合自动血管跟踪在盆腔充血综合征静脉栓塞中的应用。
IF 8.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-12-20 DOI: 10.1016/j.diii.2025.12.001
Eva Fourage-Jambon, Thomas Linet, Rim Maaloum, Yann Le Bras, Nicolas Pangon, Clément Marcelin, Joffrey Perrin, Rachel Testard, Julien Loric, Hugo Leclercq, Mickael Peigne
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引用次数: 0
First evaluation of color K-edge image quality using spectral photon-counting CT combined with two contrast agents: A phantom study. 光谱光子计数CT结合两种造影剂对彩色k边缘图像质量的首次评价:幻影研究。
IF 8.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-12-04 DOI: 10.1016/j.diii.2025.11.005
Ramata Coulibaly, Antoine Robert, Angèle Houmeau, Christian A Hernandez, Agnieszka Gutwinska, Maria Nicole Antonuccio, Simon Rit, Joël Greffier, Salim A Si-Mohamed

Purpose: The purpose of this study was to assess the image quality of color K-edge imaging obtained with a spectral photon-counting CT (SPCCT) scanner using a spectral phantom with a mixture of iodine-based and gadolinium-based contrast agents.

Materials and methods: A clinical SPCCT scanner prototype was used to scan a spectral phantom. Three dedicated cavities were filled with three contrast agents including iodine alone, gadolinium alone and a mixture of both. Two concentrations of 0.5 and 2 mg/mL were evaluated using nine helical PCCT scans at 120 kVp and 150 mAs. Conventional, color iodine and color K-edge gadolinium images were obtained through a material decomposition algorithm using three basis materials (water, iodine, gadolinium). Attenuation (in Hounsfield unit [HU]), iodine and gadolinium concentrations and task-based transfer function (TTF) were measured on each cavity and image. The noise power spectrum (NPS) was calculated on the phantom's background.

Results: Color K-edge imaging differentiated iodine and gadolinium but underestimated their concentrations. Gadolinium concentrations were underestimated by 9.4 ± 2.2 (standard deviation [SD]) % and 9.2 ± 1.0 (SD) % for gadolinium alone, 14.9 ± 2.3 (SD) % and 11.4 ± 1.2 (SD) % for the mixture, at 0.5 and 2 mg/mL, respectively. Similar TTF values at 50 % were found for color iodine (0.43 ± 0.01 [SD] mm-1) and color K-edge gadolinium (0.45 ± 0.03 (SD) mm-1) images for respective cavities at 2 mg/mL but the lowest values were found for color K-edge gadolinium images (0.43 ± 0.01 [SD] mm-1vs. 0.29 ± 0.01 [SD] mm-1) at 0.5 mg/mL. The value of noise magnitude was 24.75 HU, 0.06 mg/mL and 0.03 mg/mL for conventional, color iodine and color K-edge gadolinium images, respectively.

Conclusion: Color K-edge imaging helps distinguish between contrast agents while being associated with lownoise magnitude, high-frequency spatial noise and high spatial resolution.

目的:本研究的目的是评估光谱光子计数CT (SPCCT)扫描仪使用光谱幻影与碘基和钆基对比剂的混合物获得的彩色k边缘成像的图像质量。材料与方法:使用临床SPCCT扫描仪原型扫描光谱幻像。三个专用腔内填充了三种造影剂,包括单独的碘,单独的钆和两者的混合物。在120 kVp和150 ma下,使用9次螺旋PCCT扫描评估0.5和2 mg/mL两种浓度。采用水、碘、钆三种基材进行材料分解,得到常规图像、彩色图像和彩色k边图像。在每个空腔和图像上测量衰减(Hounsfield单位[HU])、碘和钆浓度以及基于任务的传递函数(TTF)。在图像背景下计算噪声功率谱(NPS)。结果:彩色k边缘成像可区分碘和钆,但低估了它们的浓度。在0.5 mg/mL和2 mg/mL条件下,钆浓度分别被低估了9.4±2.2(标准差[SD]) %和9.2±1.0 (SD) %, 14.9±2.3 (SD) %和11.4±1.2 (SD) %。彩色碘(0.43±0.01 [SD] mm-1)和彩色K-edge钆(0.45±0.03 (SD) mm-1)在2 mg/mL浓度下,各空腔的TTF值相似,均为50%,但彩色K-edge钆图像的TTF值最低,为0.43±0.01 [SD] mm-1vs。0.29±0.01 [SD] mm-1), 0.5 mg/mL。常规图像、彩色碘图像和彩色k边钆图像的噪声值分别为24.75 HU、0.06 mg/mL和0.03 mg/mL。结论:彩色k边缘成像有助于区分造影剂,同时具有低噪声幅度、高空间噪声和高空间分辨率的特点。
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引用次数: 0
Contribution of a new super-resolution deep-learning image reconstruction algorithm coupled with an extended matrix to cardiac CT image quality 结合扩展矩阵的超分辨率深度学习图像重建算法对心脏CT图像质量的贡献。
IF 8.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-12-01 DOI: 10.1016/j.diii.2025.06.004
Joël Greffier , Djamel Dabli , Fabien de Oliveira , Jean-Paul Beregi , Mickaël Ohana
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引用次数: 0
Superior mesenteric vein aneurysm: CT and cinematic rendering imaging features 肠系膜上静脉动脉瘤:CT和电影渲染成像特征。
IF 8.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-12-01 DOI: 10.1016/j.diii.2025.10.003
Taha M Ahmed, Elliot K. Fishman
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引用次数: 0
Color K-edge photon-counting CT with an optimized gadolinium chelate: A new era for vascular imaging 优化钆螯合物的彩色k边光子计数CT:血管成像的新时代。
IF 8.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-12-01 DOI: 10.1016/j.diii.2025.08.001
David A Bluemke, Thomas M. Grist
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引用次数: 0
期刊
Diagnostic and Interventional Imaging
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