Pub Date : 2026-01-10DOI: 10.1016/j.diii.2026.01.001
Bon-Marin Mulot, Hajer Chennoufi, Matthieu Demeyere, Sara Boccalini, Jean-Nicolas Dacher
Cardiac magnetic resonance imaging (MRI) is a valuable tool for ruling out coronary artery disease, assessing cardiac viability, diagnosing myocardial ischemia, and providing prognostic information. Cardiac MRI, including vasodilator-induced first-pass perfusion imaging, is recommended for patients with a high probability of coronary disease, prior to revascularization, and when a viability assessment is necessary. Adenosine is the most commonly used vasodilating agent for stress cardiac MRI worldwide. However, regadenoson, which is an adenosine A2A receptor agonist, is a highly suitable alternative for stress cardiac MRI due to its kinetic properties, ease of use, single-dose administration, limited contraindications, and prognostic value. This technical note describes the characteristics and safety profile of regadenoson and discusses its application to cardiac MRI and reimbursement issues.
{"title":"Using regadenoson for stress first-pass perfusion cardiac MR imaging: How, when, and why?","authors":"Bon-Marin Mulot, Hajer Chennoufi, Matthieu Demeyere, Sara Boccalini, Jean-Nicolas Dacher","doi":"10.1016/j.diii.2026.01.001","DOIUrl":"https://doi.org/10.1016/j.diii.2026.01.001","url":null,"abstract":"<p><p>Cardiac magnetic resonance imaging (MRI) is a valuable tool for ruling out coronary artery disease, assessing cardiac viability, diagnosing myocardial ischemia, and providing prognostic information. Cardiac MRI, including vasodilator-induced first-pass perfusion imaging, is recommended for patients with a high probability of coronary disease, prior to revascularization, and when a viability assessment is necessary. Adenosine is the most commonly used vasodilating agent for stress cardiac MRI worldwide. However, regadenoson, which is an adenosine A2A receptor agonist, is a highly suitable alternative for stress cardiac MRI due to its kinetic properties, ease of use, single-dose administration, limited contraindications, and prognostic value. This technical note describes the characteristics and safety profile of regadenoson and discusses its application to cardiac MRI and reimbursement issues.</p>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.diii.2025.12.005
Roberto Luigi Cazzato, Afshin Gangi
{"title":"Percutaneous screw fixation using cone-beam computed tomography navigation: A new standard of care for the treatment of traumatic pelvic fractures.","authors":"Roberto Luigi Cazzato, Afshin Gangi","doi":"10.1016/j.diii.2025.12.005","DOIUrl":"https://doi.org/10.1016/j.diii.2025.12.005","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.diii.2025.12.004
Marie Pauline Talabard , Virginie Audard , David Biau
{"title":"CT and MR imaging features of periosteal chondrosarcoma","authors":"Marie Pauline Talabard , Virginie Audard , David Biau","doi":"10.1016/j.diii.2025.12.004","DOIUrl":"10.1016/j.diii.2025.12.004","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"107 2","pages":"Pages 83-84"},"PeriodicalIF":8.1,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.diii.2025.12.003
Joël Greffier, Djamel Dabli
{"title":"Photon-counting CT: A game changer in pediatric CT.","authors":"Joël Greffier, Djamel Dabli","doi":"10.1016/j.diii.2025.12.003","DOIUrl":"https://doi.org/10.1016/j.diii.2025.12.003","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.diii.2025.12.006
Lotfi Hacein-Bey
{"title":"Deep learning-based image reconstruction best contributes to image quality enhancement under close expert supervision.","authors":"Lotfi Hacein-Bey","doi":"10.1016/j.diii.2025.12.006","DOIUrl":"https://doi.org/10.1016/j.diii.2025.12.006","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.diii.2025.09.005
Anna Pellat , Maxime Barat
{"title":"Transarterial radioembolization challenges immunotherapy as first-line care for hepatocellular carcinoma with portal vein tumor thrombosis","authors":"Anna Pellat , Maxime Barat","doi":"10.1016/j.diii.2025.09.005","DOIUrl":"10.1016/j.diii.2025.09.005","url":null,"abstract":"","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"107 1","pages":"Pages 1-2"},"PeriodicalIF":8.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.diii.2025.09.001
Christos Gkizas , Benjamin Longere , Saad Bechrouri , Helene Ridon , Aimee Rodriguez Musso , Mehdi Haidar , Cedric Croisille , David Montaigne , Pascal De Groote , Francois Pontana
Purpose
The purpose of this study was to evaluate the diagnostic performance of myocardial extracellular volume (ECV) quantification using dual-source photon-counting detector computed tomography (PCCT) compared to cardiac magnetic resonance imaging (MRI) for assessing the severity of myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM).
Materials and methods
Patients with HCM due to sarcomere mutations underwent cardiac computed tomography angiography (CCTA) using a first-generation PCCT scanner, followed by comprehensive cardiac MRI. The CCTA protocol included a late iodine enhancement acquisition in spectral mode, 5 min after contrast media injection. ECV was calculated from the iodine ratio of the myocardium and blood pool on late iodine enhancement PCCT images. Cardiac MRI biomarkers included T1 mapping, ECV, and late gadolinium enhancement percentage (LGE). Diagnostic capabilities of PCCT were estimated using sensitivity, specificity, accuracy, interobserver agreement for myocardial fibrosis, area under the receiver operating characteristic curve (AUC) analyses for optimal thresholds, and correlations between tissue characteristics, functional capacity, and biomarkers.
Results
Thirty patients were retrospectively included. There were 22 men and eight women with a mean age of 59 ± 13.8 (standard deviation [SD]). The mean dose length product of late enhancement PCCT scanning was 105 ± 45 (SD) mGy.cm. No significant differences were found between global PCCT-derived ECV (30.0 ± 4.8 [SD] %) and MRI-derived ECV (30.62 ± 4.2 [SD] %) (P = 0.59). Linear regression revealed a strong segmental correlation between PCCT and MRI (basal, r = 0.89; mid-ventricular, r = 0.85; apical, r = 0.85; P < 0.001). An optimal PCCT-derived ECV threshold of 33.4 % allowed the diagnosis of LGE ≥ 15 % with 80 % sensitivity, 76 % specificity, and an AUC of 0.77, not significantly different from MRI-derived ECV (threshold 33.9 %; sensitivity, 80 %; specificity, 76 %, AUC, 0.80; P = 0.176). PCCT-derived ECV correlated with peak VO₂ (r = -0.76) and NT-proBNP levels (r = 0.59).
Conclusion
PCCT-derived ECV shows promise for quantifying myocardial fibrosis in HCM, offering a valuable non-invasive alternative to cardiac MRI, especially for patients with contraindications or those requiring combined CCTA and myocardial assessment.
{"title":"Photon-counting CT myocardial extracellular volume: A non-invasive biomarker for fibrosis in patients with hypertrophic cardiomyopathy","authors":"Christos Gkizas , Benjamin Longere , Saad Bechrouri , Helene Ridon , Aimee Rodriguez Musso , Mehdi Haidar , Cedric Croisille , David Montaigne , Pascal De Groote , Francois Pontana","doi":"10.1016/j.diii.2025.09.001","DOIUrl":"10.1016/j.diii.2025.09.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to evaluate the diagnostic performance of myocardial extracellular volume (ECV) quantification using dual-source photon-counting detector computed tomography (PCCT) compared to cardiac magnetic resonance imaging (MRI) for assessing the severity of myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM).</div></div><div><h3>Materials and methods</h3><div>Patients with HCM due to sarcomere mutations underwent cardiac computed tomography angiography (CCTA) using a first-generation PCCT scanner, followed by comprehensive cardiac MRI. The CCTA protocol included a late iodine enhancement acquisition in spectral mode, 5 min after contrast media injection. ECV was calculated from the iodine ratio of the myocardium and blood pool on late iodine enhancement PCCT images. Cardiac MRI biomarkers included T1 mapping, ECV, and late gadolinium enhancement percentage (LGE). Diagnostic capabilities of PCCT were estimated using sensitivity, specificity, accuracy, interobserver agreement for myocardial fibrosis, area under the receiver operating characteristic curve (AUC) analyses for optimal thresholds, and correlations between tissue characteristics, functional capacity, and biomarkers.</div></div><div><h3>Results</h3><div>Thirty patients were retrospectively included. There were 22 men and eight women with a mean age of 59 ± 13.8 (standard deviation [SD]). The mean dose length product of late enhancement PCCT scanning was 105 ± 45 (SD) mGy.cm. No significant differences were found between global PCCT-derived ECV (30.0 ± 4.8 [SD] %) and MRI-derived ECV (30.62 ± 4.2 [SD] %) (<em>P</em> = 0.59). Linear regression revealed a strong segmental correlation between PCCT and MRI (basal, <em>r</em> = 0.89; mid-ventricular, <em>r</em> = 0.85; apical, <em>r</em> = 0.85; <em>P</em> < 0.001). An optimal PCCT-derived ECV threshold of 33.4 % allowed the diagnosis of LGE ≥ 15 % with 80 % sensitivity, 76 % specificity, and an AUC of 0.77, not significantly different from MRI-derived ECV (threshold 33.9 %; sensitivity, 80 %; specificity, 76 %, AUC, 0.80; <em>P</em> = 0.176). PCCT-derived ECV correlated with peak VO₂ (<em>r</em> = -0.76) and NT-proBNP levels (<em>r</em> = 0.59).</div></div><div><h3>Conclusion</h3><div>PCCT-derived ECV shows promise for quantifying myocardial fibrosis in HCM, offering a valuable non-invasive alternative to cardiac MRI, especially for patients with contraindications or those requiring combined CCTA and myocardial assessment.</div></div>","PeriodicalId":48656,"journal":{"name":"Diagnostic and Interventional Imaging","volume":"107 1","pages":"Pages 17-24"},"PeriodicalIF":8.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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